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Compile Data Set for Download or QSAR

Found 301 hits Enz. Inhib. hit(s) with Target = 'Cyclin-Dependent Kinase 6 (CDK6)'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
CDK6/cyclin D2


(Homo sapiens (human))
BDBM132275
PNG
(US8841312, 17)
Show SMILES C1CN(CCN1)c1ccc(Nc2ncc3c(n2)n(-c2ccccc2)c2cnccc32)cc1
Show InChI InChI=1S/C25H23N7/c1-2-4-20(5-3-1)32-23-17-27-11-10-21(23)22-16-28-25(30-24(22)32)29-18-6-8-19(9-7-18)31-14-12-26-13-15-31/h1-11,16-17,26H,12-15H2,(H,28,29,30)
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US Patent
n/an/a 0.360n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)

More data for this
Ligand-Target Pair
CDK6/cyclin D2


(Homo sapiens (human))
BDBM132279
PNG
(US8841312, 21)
Show SMILES C1CCC(CC1)n1c2ccccc2c2cnc(Nc3ccc(cc3)N3CCNCC3)nc12
Show InChI InChI=1S/C26H30N6/c1-2-6-21(7-3-1)32-24-9-5-4-8-22(24)23-18-28-26(30-25(23)32)29-19-10-12-20(13-11-19)31-16-14-27-15-17-31/h4-5,8-13,18,21,27H,1-3,6-7,14-17H2,(H,28,29,30)
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n/an/a 0.410n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)

More data for this
Ligand-Target Pair
CDK6/cyclin D2


(Homo sapiens (human))
BDBM132303
PNG
(US8841312, 46)
Show SMILES C1CN(CCN1)c1ccc(Nc2ncc3c(n2)n(C2CCOCC2)c2ccccc32)cc1
Show InChI InChI=1S/C25H28N6O/c1-2-4-23-21(3-1)22-17-27-25(29-24(22)31(23)20-9-15-32-16-10-20)28-18-5-7-19(8-6-18)30-13-11-26-12-14-30/h1-8,17,20,26H,9-16H2,(H,27,28,29)
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n/an/a 0.75n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)

More data for this
Ligand-Target Pair
CDK6/cyclin D2


(Homo sapiens (human))
BDBM50001539
PNG
(CHEMBL3237704 | US8841312, 204)
Show SMILES CC1(C)CCC(CC1)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12
Show InChI InChI=1S/C26H32N8/c1-26(2)8-5-18(6-9-26)34-22-17-28-10-7-20(22)21-16-30-25(32-24(21)34)31-23-4-3-19(15-29-23)33-13-11-27-12-14-33/h3-4,7,10,15-18,27H,5-6,8-9,11-14H2,1-2H3,(H,29,30,31,32)
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n/an/a 1.10n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)

More data for this
Ligand-Target Pair
CDK6/cyclin D2


(Homo sapiens (human))
BDBM132266
PNG
(US8841312, 8)
Show SMILES C1CCC(C1)n1c2cnccc2c2cnc(Nc3cnc(nc3)N3CCNCC3)nc12
Show InChI InChI=1S/C22H25N9/c1-2-4-16(3-1)31-19-14-24-6-5-17(19)18-13-25-21(29-20(18)31)28-15-11-26-22(27-12-15)30-9-7-23-8-10-30/h5-6,11-14,16,23H,1-4,7-10H2,(H,25,28,29)
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n/an/a 1.10n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)

More data for this
Ligand-Target Pair
CDK6/cyclin D2


(Homo sapiens (human))
BDBM132294
PNG
(US8841312, 37)
Show SMILES C1CCC(C1)n1c2ccccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12
Show InChI InChI=1S/C24H27N7/c1-2-6-17(5-1)31-21-8-4-3-7-19(21)20-16-27-24(29-23(20)31)28-22-10-9-18(15-26-22)30-13-11-25-12-14-30/h3-4,7-10,15-17,25H,1-2,5-6,11-14H2,(H,26,27,28,29)
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n/an/a 1.20n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)

More data for this
Ligand-Target Pair
CDK6/cyclin D2


(Homo sapiens (human))
BDBM132265
PNG
(US8841312, 7)
Show SMILES C1CCC(C1)n1c2cnccc2c2cnc(Nc3ccc(nc3)N3CCNCC3)nc12
Show InChI InChI=1S/C23H26N8/c1-2-4-17(3-1)31-20-15-25-8-7-18(20)19-14-27-23(29-22(19)31)28-16-5-6-21(26-13-16)30-11-9-24-10-12-30/h5-8,13-15,17,24H,1-4,9-12H2,(H,27,28,29)
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n/an/a 1.30n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)

More data for this
Ligand-Target Pair
CDK6/cyclin D2


(Homo sapiens (human))
BDBM132276
PNG
(US8841312, 18)
Show SMILES O[C@@H]1CCN(C1)c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2cnccc32)nn1
Show InChI InChI=1/C22H24N8O/c31-15-8-10-29(13-15)20-6-5-19(27-28-20)25-22-24-11-17-16-7-9-23-12-18(16)30(21(17)26-22)14-3-1-2-4-14/h5-7,9,11-12,14-15,31H,1-4,8,10,13H2,(H,24,25,26,27)/t15-/s2
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n/an/a 1.5n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)

More data for this
Ligand-Target Pair
CDK6/cyclin D2


(Homo sapiens (human))
BDBM132439
PNG
(US8841312, 186A)
Show SMILES O[C@@H]1CCN(C1)c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2c(F)nccc32)nc1
Show InChI InChI=1/C23H24FN7O/c24-21-20-17(7-9-25-21)18-12-27-23(29-22(18)31(20)14-3-1-2-4-14)28-19-6-5-15(11-26-19)30-10-8-16(32)13-30/h5-7,9,11-12,14,16,32H,1-4,8,10,13H2,(H,26,27,28,29)/t16-/s2
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n/an/a 2n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)

More data for this
Ligand-Target Pair
CDK6/cyclin D2


(Homo sapiens (human))
BDBM132516
PNG
(US8841312, 265)
Show SMILES O=S1(=O)CCC(=CC1)c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2cnccc32)nc1
Show InChI InChI=1S/C24H24N6O2S/c31-33(32)11-8-16(9-12-33)17-5-6-22(26-13-17)28-24-27-14-20-19-7-10-25-15-21(19)30(23(20)29-24)18-3-1-2-4-18/h5-8,10,13-15,18H,1-4,9,11-12H2,(H,26,27,28,29)
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n/an/a 2.20n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)

More data for this
Ligand-Target Pair
CDK6/cyclin D2


(Homo sapiens (human))
BDBM132280
PNG
(US8841312, 22)
Show SMILES C1CCC(CC1)n1c2ccccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12
Show InChI InChI=1S/C25H29N7/c1-2-6-18(7-3-1)32-22-9-5-4-8-20(22)21-17-28-25(30-24(21)32)29-23-11-10-19(16-27-23)31-14-12-26-13-15-31/h4-5,8-11,16-18,26H,1-3,6-7,12-15H2,(H,27,28,29,30)
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n/an/a 2.5n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)

More data for this
Ligand-Target Pair
CDK6/cyclin D2


(Homo sapiens (human))
BDBM132271
PNG
(US8841312, 13)
Show SMILES CN(C)C1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2cnccc32)nn1
Show InChI InChI=1S/C25H31N9/c1-32(2)17-10-13-33(14-11-17)23-8-7-22(30-31-23)28-25-27-15-20-19-9-12-26-16-21(19)34(24(20)29-25)18-5-3-4-6-18/h7-9,12,15-18H,3-6,10-11,13-14H2,1-2H3,(H,27,28,29,30)
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n/an/a 2.60n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)

More data for this
Ligand-Target Pair
CDK6/cyclin D2


(Homo sapiens (human))
BDBM132297
PNG
(US8841312, 40)
Show SMILES C1CC2CC1CC2n1c2cnccc2c2cnc(Nc3ccc(cc3)N3CCNCC3)nc12
Show InChI InChI=1/C26H29N7/c1-2-18-13-17(1)14-23(18)33-24-16-28-8-7-21(24)22-15-29-26(31-25(22)33)30-19-3-5-20(6-4-19)32-11-9-27-10-12-32/h3-8,15-18,23,27H,1-2,9-14H2,(H,29,30,31)
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n/an/a 2.60n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)

More data for this
Ligand-Target Pair
CDK6/cyclin D2


(Homo sapiens (human))
BDBM132357
PNG
(US8841312, 103)
Show SMILES OCC1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1
Show InChI InChI=1S/C24H28N8O/c33-15-16-8-11-31(12-9-16)22-6-5-21(29-30-22)27-24-26-13-19-18-7-10-25-14-20(18)32(23(19)28-24)17-3-1-2-4-17/h5-7,10,13-14,16-17,33H,1-4,8-9,11-12,15H2,(H,26,27,28,29)
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n/an/a 2.60n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)

More data for this
Ligand-Target Pair
CDK6/cyclin D2


(Homo sapiens (human))
BDBM132395
PNG
(US8841312, 141)
Show SMILES C(N1CCOCC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1
Show InChI InChI=1S/C24H27N7O/c1-2-4-18(3-1)31-21-15-25-8-7-19(21)20-14-27-24(29-23(20)31)28-22-6-5-17(13-26-22)16-30-9-11-32-12-10-30/h5-8,13-15,18H,1-4,9-12,16H2,(H,26,27,28,29)
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n/an/a 2.60n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)

More data for this
Ligand-Target Pair
CDK6/cyclin D2


(Homo sapiens (human))
BDBM132477
PNG
(US8841312, 226)
Show SMILES O=C1CNCCN1Cc1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1
Show InChI InChI=1S/C24H26N8O/c33-22-14-26-9-10-31(22)15-16-5-6-21(27-11-16)29-24-28-12-19-18-7-8-25-13-20(18)32(23(19)30-24)17-3-1-2-4-17/h5-8,11-13,17,26H,1-4,9-10,14-15H2,(H,27,28,29,30)
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n/an/a 2.70n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)

More data for this
Ligand-Target Pair
CDK6/cyclin D2


(Homo sapiens (human))
BDBM132406
PNG
(US8841312, 153)
Show SMILES CN(C)C1CCN(CC1)c1ccc(Nc2ncc3c4ccnc(Cl)c4n(C4CCCC4)c3n2)nc1
Show InChI InChI=1S/C26H31ClN8/c1-33(2)17-10-13-34(14-11-17)19-7-8-22(29-15-19)31-26-30-16-21-20-9-12-28-24(27)23(20)35(25(21)32-26)18-5-3-4-6-18/h7-9,12,15-18H,3-6,10-11,13-14H2,1-2H3,(H,29,30,31,32)
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n/an/a 2.80n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)

More data for this
Ligand-Target Pair
CDK6/cyclin D2


(Homo sapiens (human))
BDBM132441
PNG
(US8841312, 187)
Show SMILES OCC1CCN(CC1)c1ccc(Nc2ncc3c4ccnc(F)c4n(C4CCCC4)c3n2)nc1
Show InChI InChI=1S/C25H28FN7O/c26-23-22-19(7-10-27-23)20-14-29-25(31-24(20)33(22)17-3-1-2-4-17)30-21-6-5-18(13-28-21)32-11-8-16(15-34)9-12-32/h5-7,10,13-14,16-17,34H,1-4,8-9,11-12,15H2,(H,28,29,30,31)
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n/an/a 2.80n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)

More data for this
Ligand-Target Pair
CDK6/cyclin D2


(Homo sapiens (human))
BDBM132261
PNG
(US8841312, 3)
Show SMILES C1CCC(C1)n1c2cnccc2c2cnc(Nc3ccc(cc3)N3CCNCC3)nc12
Show InChI InChI=1S/C24H27N7/c1-2-4-19(3-1)31-22-16-26-10-9-20(22)21-15-27-24(29-23(21)31)28-17-5-7-18(8-6-17)30-13-11-25-12-14-30/h5-10,15-16,19,25H,1-4,11-14H2,(H,27,28,29)
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n/an/a 2.90n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)

More data for this
Ligand-Target Pair
CDK6/cyclin D2


(Homo sapiens (human))
BDBM132476
PNG
(US8841312, 225)
Show SMILES O=C1CN(Cc2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CCN1
Show InChI InChI=1S/C24H26N8O/c33-22-15-31(10-9-26-22)14-16-5-6-21(27-11-16)29-24-28-12-19-18-7-8-25-13-20(18)32(23(19)30-24)17-3-1-2-4-17/h5-8,11-13,17H,1-4,9-10,14-15H2,(H,26,33)(H,27,28,29,30)
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n/an/a 3n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)

More data for this
Ligand-Target Pair
CDK6/cyclin D2


(Homo sapiens (human))
BDBM132714
PNG
(US8841312, 464)
Show SMILES CCNC1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1
Show InChI InChI=1S/C26H32N8/c1-2-28-18-10-13-33(14-11-18)20-7-8-24(29-15-20)31-26-30-16-22-21-9-12-27-17-23(21)34(25(22)32-26)19-5-3-4-6-19/h7-9,12,15-19,28H,2-6,10-11,13-14H2,1H3,(H,29,30,31,32)
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n/an/a 3.10n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)

More data for this
Ligand-Target Pair
CDK6/cyclin D2


(Homo sapiens (human))
BDBM132296
PNG
(US8841312, 39)
Show SMILES C1CN(CCN1)c1ccc(Nc2ncc3c(n2)n(C2CCCCCC2)c2ccccc32)nc1
Show InChI InChI=1S/C26H31N7/c1-2-4-8-19(7-3-1)33-23-10-6-5-9-21(23)22-18-29-26(31-25(22)33)30-24-12-11-20(17-28-24)32-15-13-27-14-16-32/h5-6,9-12,17-19,27H,1-4,7-8,13-16H2,(H,28,29,30,31)
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n/an/a 3.10n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)

More data for this
Ligand-Target Pair
CDK6/cyclin D2


(Homo sapiens (human))
BDBM132478
PNG
(US8841312, 227)
Show SMILES O=S(=O)(N1CCNCC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1
Show InChI InChI=1S/C23H26N8O2S/c32-34(33,30-11-9-24-10-12-30)17-5-6-21(26-13-17)28-23-27-14-19-18-7-8-25-15-20(18)31(22(19)29-23)16-3-1-2-4-16/h5-8,13-16,24H,1-4,9-12H2,(H,26,27,28,29)
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n/an/a 3.10n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)

More data for this
Ligand-Target Pair
CDK6/cyclin D2


(Homo sapiens (human))
BDBM132471
PNG
(US8841312, 220)
Show SMILES OC(=O)CN1CCN(Cc2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1
Show InChI InChI=1S/C26H30N8O2/c35-24(36)17-33-11-9-32(10-12-33)16-18-5-6-23(28-13-18)30-26-29-14-21-20-7-8-27-15-22(20)34(25(21)31-26)19-3-1-2-4-19/h5-8,13-15,19H,1-4,9-12,16-17H2,(H,35,36)(H,28,29,30,31)
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n/an/a 3.30n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)

More data for this
Ligand-Target Pair
CDK6/cyclin D2


(Homo sapiens (human))
BDBM132283
PNG
(US8841312, 26)
Show SMILES C1CN(CCN1)c1ccc(Nc2ncc3c(n2)n(c2cnccc32)C23CC4CC(CC(C4)C2)C3)nc1
Show InChI InChI=1S/C28H32N8/c1-2-25(31-15-21(1)35-7-5-29-6-8-35)33-27-32-16-23-22-3-4-30-17-24(22)36(26(23)34-27)28-12-18-9-19(13-28)11-20(10-18)14-28/h1-4,15-20,29H,5-14H2,(H,31,32,33,34)
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n/an/a 3.5n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)

More data for this
Ligand-Target Pair
CDK6/cyclin D2


(Homo sapiens (human))
BDBM132469
PNG
(US8841312, 218)
Show SMILES OC(=O)CN1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1
Show InChI InChI=1S/C24H27N9O2/c34-22(35)15-31-9-11-32(12-10-31)21-6-5-20(29-30-21)27-24-26-13-18-17-7-8-25-14-19(17)33(23(18)28-24)16-3-1-2-4-16/h5-8,13-14,16H,1-4,9-12,15H2,(H,34,35)(H,26,27,28,29)
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n/an/a 3.60n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)

More data for this
Ligand-Target Pair
CDK6/cyclin D2


(Homo sapiens (human))
BDBM132304
PNG
(US8841312, 47)
Show SMILES C1CCC(C1)n1c2ccccc2c2cnc(Nc3ccc(cc3)N3CCNCC3)nc12
Show InChI InChI=1S/C25H28N6/c1-2-6-20(5-1)31-23-8-4-3-7-21(23)22-17-27-25(29-24(22)31)28-18-9-11-19(12-10-18)30-15-13-26-14-16-30/h3-4,7-12,17,20,26H,1-2,5-6,13-16H2,(H,27,28,29)
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n/an/a 3.70n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)

More data for this
Ligand-Target Pair
CDK6/cyclin D2


(Homo sapiens (human))
BDBM132691
PNG
(US8841312, 441)
Show SMILES C[C@@H](O)CNC1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1
Show InChI InChI=1/C26H33N9O/c1-17(36)14-28-18-9-12-34(13-10-18)24-7-6-23(32-33-24)30-26-29-15-21-20-8-11-27-16-22(20)35(25(21)31-26)19-4-2-3-5-19/h6-8,11,15-19,28,36H,2-5,9-10,12-14H2,1H3,(H,29,30,31,32)/t17-/s2
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n/an/a 3.80n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)

More data for this
Ligand-Target Pair
CDK6/cyclin D2


(Homo sapiens (human))
BDBM132479
PNG
(US8841312, 228)
Show SMILES Fc1nccc2c3cnc(Nc4ccc(cn4)S(=O)(=O)N4CCNCC4)nc3n(C3CCCC3)c12
Show InChI InChI=1S/C23H25FN8O2S/c24-21-20-17(7-8-26-21)18-14-28-23(30-22(18)32(20)15-3-1-2-4-15)29-19-6-5-16(13-27-19)35(33,34)31-11-9-25-10-12-31/h5-8,13-15,25H,1-4,9-12H2,(H,27,28,29,30)
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n/an/a 3.90n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)

More data for this
Ligand-Target Pair
CDK6/cyclin D2


(Homo sapiens (human))
BDBM132263
PNG
(US8841312, 5)
Show SMILES Cc1cc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)cnc1N1CCNCC1
Show InChI InChI=1S/C24H28N8/c1-16-12-17(13-27-22(16)31-10-8-25-9-11-31)29-24-28-14-20-19-6-7-26-15-21(19)32(23(20)30-24)18-4-2-3-5-18/h6-7,12-15,18,25H,2-5,8-11H2,1H3,(H,28,29,30)
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n/an/a 4.20n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)

More data for this
Ligand-Target Pair
CDK6/cyclin D2


(Homo sapiens (human))
BDBM50001586
PNG
(CHEMBL3237444 | US8841312, 152)
Show SMILES Clc1nccc2c3cnc(Nc4ccc(cn4)N4CCNCC4)nc3n(C3CCCC3)c12
Show InChI InChI=1S/C23H25ClN8/c24-21-20-17(7-8-26-21)18-14-28-23(30-22(18)32(20)15-3-1-2-4-15)29-19-6-5-16(13-27-19)31-11-9-25-10-12-31/h5-8,13-15,25H,1-4,9-12H2,(H,27,28,29,30)
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n/an/a 4.30n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)

More data for this
Ligand-Target Pair
CDK6/cyclin D2


(Homo sapiens (human))
BDBM132293
PNG
(US8841312, 36)
Show SMILES C1CCC(C1)n1c2ncccc2c2cnc(Nc3ccc(cc3)N3CCNCC3)nc12
Show InChI InChI=1S/C24H27N7/c1-2-5-19(4-1)31-22-20(6-3-11-26-22)21-16-27-24(29-23(21)31)28-17-7-9-18(10-8-17)30-14-12-25-13-15-30/h3,6-11,16,19,25H,1-2,4-5,12-15H2,(H,27,28,29)
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n/an/a 4.40n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)

More data for this
Ligand-Target Pair
CDK6/cyclin D2


(Homo sapiens (human))
BDBM50001584
PNG
(CHEMBL3237442 | US8841312, 1)
Show SMILES C1CCC(C1)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12
Show InChI InChI=1S/C23H26N8/c1-2-4-16(3-1)31-20-15-25-8-7-18(20)19-14-27-23(29-22(19)31)28-21-6-5-17(13-26-21)30-11-9-24-10-12-30/h5-8,13-16,24H,1-4,9-12H2,(H,26,27,28,29)
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n/an/a 4.40n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
CDK6/cyclin D2


(Homo sapiens (human))
BDBM50001537
PNG
(CHEMBL3237702 | US8841312, 55)
Show SMILES CC1CCC(CC1)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12
Show InChI InChI=1S/C25H30N8/c1-17-2-4-18(5-3-17)33-22-16-27-9-8-20(22)21-15-29-25(31-24(21)33)30-23-7-6-19(14-28-23)32-12-10-26-11-13-32/h6-9,14-18,26H,2-5,10-13H2,1H3,(H,28,29,30,31)
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n/an/a 4.40n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)

More data for this
Ligand-Target Pair
CDK6/cyclin D2


(Homo sapiens (human))
BDBM132491
PNG
(US8841312, 240)
Show SMILES C1CCC(CC1)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)cc12
Show InChI InChI=1S/C25H29N7/c1-2-4-18(5-3-1)32-22-14-25(29-16-21(22)20-8-9-27-17-23(20)32)30-24-7-6-19(15-28-24)31-12-10-26-11-13-31/h6-9,14-18,26H,1-5,10-13H2,(H,28,29,30)
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n/an/a 4.60n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)

More data for this
Ligand-Target Pair
CDK6/cyclin D2


(Homo sapiens (human))
BDBM132398
PNG
(US8841312, 144)
Show SMILES CCN(CC)C1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1
Show InChI InChI=1S/C28H36N8/c1-3-34(4-2)20-12-15-35(16-13-20)22-9-10-26(30-17-22)32-28-31-18-24-23-11-14-29-19-25(23)36(27(24)33-28)21-7-5-6-8-21/h9-11,14,17-21H,3-8,12-13,15-16H2,1-2H3,(H,30,31,32,33)
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n/an/a 4.60n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)

More data for this
Ligand-Target Pair
CDK6/cyclin D2


(Homo sapiens (human))
BDBM132696
PNG
(US8841312, 446)
Show SMILES OC[C@H](O)CNC1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1
Show InChI InChI=1/C26H33N9O2/c36-16-19(37)13-28-17-8-11-34(12-9-17)24-6-5-23(32-33-24)30-26-29-14-21-20-7-10-27-15-22(20)35(25(21)31-26)18-3-1-2-4-18/h5-7,10,14-15,17-19,28,36-37H,1-4,8-9,11-13,16H2,(H,29,30,31,32)/t19-/s2
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n/an/a 4.80n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)

More data for this
Ligand-Target Pair
CDK6/cyclin D2


(Homo sapiens (human))
BDBM132413
PNG
(US8841312, 160)
Show SMILES CC(C)n1c2cnccc2c2cnc(Nc3ccc(nn3)N3CCC(CC3)N(C)C)nc12
Show InChI InChI=1S/C23H29N9/c1-15(2)32-19-14-24-10-7-17(19)18-13-25-23(27-22(18)32)26-20-5-6-21(29-28-20)31-11-8-16(9-12-31)30(3)4/h5-7,10,13-16H,8-9,11-12H2,1-4H3,(H,25,26,27,28)
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US Patent
n/an/a 4.80n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)

More data for this
Ligand-Target Pair
CDK6/cyclin D2


(Homo sapiens (human))
BDBM132440
PNG
(US8841312, 186B)
Show SMILES O[C@H]1CCN(C1)c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2c(F)nccc32)nc1
Show InChI InChI=1/C23H24FN7O/c24-21-20-17(7-9-25-21)18-12-27-23(29-22(18)31(20)14-3-1-2-4-14)28-19-6-5-15(11-26-19)30-10-8-16(32)13-30/h5-7,9,11-12,14,16,32H,1-4,8,10,13H2,(H,26,27,28,29)/t16-/s2
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US Patent
n/an/a 4.80n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)

More data for this
Ligand-Target Pair
CDK6/cyclin D2


(Homo sapiens (human))
BDBM132444
PNG
(US8841312, 191)
Show SMILES OCCN1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1
Show InChI InChI=1S/C25H30N8O/c34-14-13-31-9-11-32(12-10-31)19-5-6-23(27-15-19)29-25-28-16-21-20-7-8-26-17-22(20)33(24(21)30-25)18-3-1-2-4-18/h5-8,15-18,34H,1-4,9-14H2,(H,27,28,29,30)
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US Patent
n/an/a 4.90n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)

More data for this
Ligand-Target Pair
CDK6/cyclin D2


(Homo sapiens (human))
BDBM132396
PNG
(US8841312, 142)
Show SMILES COCCN1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1
Show InChI InChI=1S/C26H32N8O/c1-35-15-14-32-10-12-33(13-11-32)20-6-7-24(28-16-20)30-26-29-17-22-21-8-9-27-18-23(21)34(25(22)31-26)19-4-2-3-5-19/h6-9,16-19H,2-5,10-15H2,1H3,(H,28,29,30,31)
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US Patent
n/an/a 4.90n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)

More data for this
Ligand-Target Pair
CDK6/cyclin D2


(Homo sapiens (human))
BDBM132503
PNG
(US8841312, 252)
Show SMILES CN(C)C1CCN(CC1)c1ccc(Nc2ncc3c4ccnc(F)c4n(C4CCCC4)c3n2)nn1
Show InChI InChI=1S/C25H30FN9/c1-33(2)16-10-13-34(14-11-16)21-8-7-20(31-32-21)29-25-28-15-19-18-9-12-27-23(26)22(18)35(24(19)30-25)17-5-3-4-6-17/h7-9,12,15-17H,3-6,10-11,13-14H2,1-2H3,(H,28,29,30,31)
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US Patent
n/an/a 5n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)

More data for this
Ligand-Target Pair
CDK6/cyclin D2


(Homo sapiens (human))
BDBM132708
PNG
(US8841312, 458)
Show SMILES OCCNC1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1
Show InChI InChI=1S/C26H32N8O/c35-14-11-28-18-8-12-33(13-9-18)20-5-6-24(29-15-20)31-26-30-16-22-21-7-10-27-17-23(21)34(25(22)32-26)19-3-1-2-4-19/h5-7,10,15-19,28,35H,1-4,8-9,11-14H2,(H,29,30,31,32)
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US Patent
n/an/a 5.10n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)

More data for this
Ligand-Target Pair
CDK6/cyclin D2


(Homo sapiens (human))
BDBM132727
PNG
(US8841312, 477)
Show SMILES OC(=O)CNC1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1
Show InChI InChI=1S/C26H30N8O2/c35-24(36)16-28-17-8-11-33(12-9-17)19-5-6-23(29-13-19)31-26-30-14-21-20-7-10-27-15-22(20)34(25(21)32-26)18-3-1-2-4-18/h5-7,10,13-15,17-18,28H,1-4,8-9,11-12,16H2,(H,35,36)(H,29,30,31,32)
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US Patent
n/an/a 5.10n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)

More data for this
Ligand-Target Pair
CDK6/cyclin D2


(Homo sapiens (human))
BDBM132686
PNG
(US8841312, 436)
Show SMILES C[C@H](CO)NC1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1
Show InChI InChI=1/C27H34N8O/c1-18(17-36)31-19-9-12-34(13-10-19)21-6-7-25(29-14-21)32-27-30-15-23-22-8-11-28-16-24(22)35(26(23)33-27)20-4-2-3-5-20/h6-8,11,14-16,18-20,31,36H,2-5,9-10,12-13,17H2,1H3,(H,29,30,32,33)/t18-/s2
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US Patent
n/an/a 5.10n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)

More data for this
Ligand-Target Pair
CDK6/cyclin D2


(Homo sapiens (human))
BDBM132281
PNG
(US8841312, 24)
Show SMILES C1CC2CC1CC2n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12
Show InChI InChI=1/C25H28N8/c1-2-17-11-16(1)12-21(17)33-22-15-27-6-5-19(22)20-14-29-25(31-24(20)33)30-23-4-3-18(13-28-23)32-9-7-26-8-10-32/h3-6,13-17,21,26H,1-2,7-12H2,(H,28,29,30,31)
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US Patent
n/an/a 5.10n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)

More data for this
Ligand-Target Pair
CDK6/cyclin D2


(Homo sapiens (human))
BDBM132411
PNG
(US8841312, 158)
Show SMILES CN(C)C1CC2CCC(C1)N2c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2cnccc32)nc1
Show InChI InChI=1/C28H34N8/c1-34(2)22-13-19-7-8-20(14-22)35(19)21-9-10-26(30-15-21)32-28-31-16-24-23-11-12-29-17-25(23)36(27(24)33-28)18-5-3-4-6-18/h9-12,15-20,22H,3-8,13-14H2,1-2H3,(H,30,31,32,33)
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US Patent
n/an/a 5.30n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)

More data for this
Ligand-Target Pair
CDK6/cyclin D2


(Homo sapiens (human))
BDBM132508
PNG
(US8841312, 257)
Show SMILES C1CCC(C1)n1c2cnccc2c2cnc(Nc3ccc(cn3)C3CCNCC3)nc12
Show InChI InChI=1S/C24H27N7/c1-2-4-18(3-1)31-21-15-26-12-9-19(21)20-14-28-24(30-23(20)31)29-22-6-5-17(13-27-22)16-7-10-25-11-8-16/h5-6,9,12-16,18,25H,1-4,7-8,10-11H2,(H,27,28,29,30)
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US Patent
n/an/a 5.30n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)

More data for this
Ligand-Target Pair
CDK6/cyclin D2


(Homo sapiens (human))
BDBM132305
PNG
(US8841312, 48)
Show SMILES C1CCC(C1)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCCNCC3)nc12
Show InChI InChI=1S/C24H28N8/c1-2-5-17(4-1)32-21-16-26-10-8-19(21)20-15-28-24(30-23(20)32)29-22-7-6-18(14-27-22)31-12-3-9-25-11-13-31/h6-8,10,14-17,25H,1-5,9,11-13H2,(H,27,28,29,30)
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US Patent
n/an/a 5.60n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)

More data for this
Ligand-Target Pair
CDK6/cyclin D2


(Homo sapiens (human))
BDBM132728
PNG
(US8841312, 478)
Show SMILES OC(=O)CNC1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1
Show InChI InChI=1S/C25H29N9O2/c35-23(36)15-27-16-8-11-33(12-9-16)22-6-5-21(31-32-22)29-25-28-13-19-18-7-10-26-14-20(18)34(24(19)30-25)17-3-1-2-4-17/h5-7,10,13-14,16-17,27H,1-4,8-9,11-12,15H2,(H,35,36)(H,28,29,30,31)
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US Patent
n/an/a 5.70n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)

More data for this
Ligand-Target Pair
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