Found 1727 hits Enz. Inhib. hit(s) with Target = 'Cyclin-dependent kinase 1' Target (Institution) | Ligand | Target Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Cyclin-dependent kinase 1
(Homo sapiens (human)) | BDBM50164702
 (4-[4-(3H-Benzoimidazol-5-ylamino)-5-trifluoromethy...)Show SMILES NS(=O)(=O)c1ccc(Nc2ncc(c(Nc3ccc4nc[nH]c4c3)n2)C(F)(F)F)cc1 Show InChI InChI=1S/C18H14F3N7O2S/c19-18(20,21)13-8-23-17(27-10-1-4-12(5-2-10)31(22,29)30)28-16(13)26-11-3-6-14-15(7-11)25-9-24-14/h1-9H,(H,24,25)(H2,22,29,30)(H2,23,26,27,28) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Similars AffyNet 
| Article PubMed
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description Inhibitory concentration against Cyclin dependent kinase 1 |
Bioorg Med Chem Lett 15: 1973-7 (2005)
|
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (human)) | BDBM84533
 (Alsterpaullone derivative, 7)Show SMILES O=C1Cc2c([nH]c3ccc(cc23)N(=O)=O)-c2cc(CCC#N)ccc2N1 Show InChI InChI=1S/C19H14N4O3/c20-7-1-2-11-3-5-17-15(8-11)19-14(10-18(24)21-17)13-9-12(23(25)26)4-6-16(13)22-19/h3-6,8-9,22H,1-2,10H2,(H,21,24) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| PC cid PC sid UniChem
Similars AffyNet 
| Article PubMed
| n/a | n/a | 0.230 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Technische Universität Braunschweig
| Assay Description Kinase activity assay using GSK-3beta, CDK1/cyclin B and CDK5/p25. |
Chembiochem 6: 541-9 (2005)
|
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (human)) | BDBM2579
 ((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| Purchase
CHEMBL MMDB PC cid PC sid UniChem
Patents
Similars AffyNet 
| PubMed
| n/a | n/a | 0.490 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa
Curated by ChEMBL
| Assay Description Inhibition of human CDK1 by kinase inhibition assay |
Eur J Med Chem 103: 29-43 (2015)
|
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (human)) | BDBM50214095
 (CHEMBL248713 | CHEMBL511394 | N-((5-(3-(5-fluoro-1...)Show SMILES CCNCc1cncc(c1)-c1cnc2n[nH]c(-c3nc4ccc(F)cc4[nH]3)c2c1 Show InChI InChI=1S/C21H18FN7/c1-2-23-8-12-5-13(10-24-9-12)14-6-16-19(28-29-20(16)25-11-14)21-26-17-4-3-15(22)7-18(17)27-21/h3-7,9-11,23H,2,8H2,1H3,(H,26,27)(H,25,28,29) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Patents
Similars AffyNet 
| Article PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development L.L.C.
Curated by ChEMBL
| Assay Description Inhibition of CDK1 |
Bioorg Med Chem Lett 17: 4297-302 (2007)
|
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (human)) | BDBM50214095
 (CHEMBL248713 | CHEMBL511394 | N-((5-(3-(5-fluoro-1...)Show SMILES CCNCc1cncc(c1)-c1cnc2n[nH]c(-c3nc4ccc(F)cc4[nH]3)c2c1 Show InChI InChI=1S/C21H18FN7/c1-2-23-8-12-5-13(10-24-9-12)14-6-16-19(28-29-20(16)25-11-14)21-26-17-4-3-15(22)7-18(17)27-21/h3-7,9-11,23H,2,8H2,1H3,(H,26,27)(H,25,28,29) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Patents
Similars AffyNet 
| Article PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences Limited
Curated by ChEMBL
| Assay Description Inhibition of CDK1/cyclinB (unknown origin) |
Bioorg Med Chem 16: 7167-76 (2008)
|
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (human)) | BDBM50214115
 (CHEMBL429478 | N-((5-(3-(5-methoxy-1H-benzo[d]imid...)Show SMILES CCNCc1cncc(c1)-c1cnc2n[nH]c(-c3nc4ccc(OC)cc4[nH]3)c2c1 Show InChI InChI=1S/C22H21N7O/c1-3-23-9-13-6-14(11-24-10-13)15-7-17-20(28-29-21(17)25-12-15)22-26-18-5-4-16(30-2)8-19(18)27-22/h4-8,10-12,23H,3,9H2,1-2H3,(H,26,27)(H,25,28,29) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Patents
Similars AffyNet 
| Article PubMed
| n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development L.L.C.
Curated by ChEMBL
| Assay Description Inhibition of CDK1 |
Bioorg Med Chem Lett 17: 4297-302 (2007)
|
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (human)) | BDBM50297122
 ((R)-10-Methyl-9,10,11,12-tetrahydro-7-thia-4,9,12-...)Show InChI InChI=1S/C15H13N3OS/c1-8-7-17-13-12-9-3-2-6-16-10(9)4-5-11(12)20-14(13)15(19)18-8/h2-6,8,17H,7H2,1H3,(H,18,19)/t8-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Similars AffyNet 
| Article PubMed
| n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of CDK2 |
Bioorg Med Chem Lett 19: 4882-4 (2009)
|
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (human)) | BDBM50164693
 (CHEMBL194721 | N*2*-(3H-Benzoimidazol-5-yl)-N*4*-(...)Show SMILES FC(F)(F)c1cnc(Nc2ccc3nc[nH]c3c2)nc1Nc1ccccc1Cl Show InChI InChI=1S/C18H12ClF3N6/c19-12-3-1-2-4-13(12)27-16-11(18(20,21)22)8-23-17(28-16)26-10-5-6-14-15(7-10)25-9-24-14/h1-9H,(H,24,25)(H2,23,26,27,28) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Similars AffyNet 
| Article PubMed
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description Inhibitory concentration against Cyclin dependent kinase 1 |
Bioorg Med Chem Lett 15: 1973-7 (2005)
|
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (human)) | BDBM50297120
 ((R)-9-Methyl-8,9,10,11-tetrahydro-3-oxa-6-thia-8,1...)Show InChI InChI=1S/C14H12N2O2S/c1-7-6-15-12-11-8-4-5-18-9(8)2-3-10(11)19-13(12)14(17)16-7/h2-5,7,15H,6H2,1H3,(H,16,17)/t7-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Similars AffyNet 
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of CDK2 |
Bioorg Med Chem Lett 19: 4882-4 (2009)
|
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (human)) | BDBM50192071
 ((13R,15S)-13-methyl-16-oxa-8,9,12,22,24-pentaazahe...)Show SMILES C[C@@H]1C[C@H]2CN1CCn1[nH]c3c(cccc3c1=O)-c1nc3c(O2)cccc3[nH]c1=O Show InChI InChI=1S/C22H21N5O3/c1-12-10-13-11-26(12)8-9-27-22(29)15-5-2-4-14(18(15)25-27)19-21(28)23-16-6-3-7-17(30-13)20(16)24-19/h2-7,12-13,25H,8-11H2,1H3,(H,23,28)/t12-,13+/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Similars AffyNet 
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of CDK1 |
Bioorg Med Chem Lett 16: 5122-6 (2006)
|
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (human)) | BDBM50400801
 (CHEMBL215803)Show SMILES C[C@@H]1C[C@H]2CN1CCn1nc3c(cccc3c1O)-c1nc3c(O2)cccc3nc1O Show InChI InChI=1S/C22H21N5O3/c1-12-10-13-11-26(12)8-9-27-22(29)15-5-2-4-14(18(15)25-27)19-21(28)23-16-6-3-7-17(30-13)20(16)24-19/h2-7,12-13,25H,8-11H2,1H3,(H,23,28)/t12-,13+/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL MMDB PC cid PC sid UniChem
Similars AffyNet 
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Universite£ de Sherbrooke
Curated by ChEMBL
| Assay Description Inhibition of CDK1 |
J Med Chem 54: 1961-2004 (2011)
|
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (human)) | BDBM50164693
 (CHEMBL194721 | N*2*-(3H-Benzoimidazol-5-yl)-N*4*-(...)Show SMILES FC(F)(F)c1cnc(Nc2ccc3nc[nH]c3c2)nc1Nc1ccccc1Cl Show InChI InChI=1S/C18H12ClF3N6/c19-12-3-1-2-4-13(12)27-16-11(18(20,21)22)8-23-17(28-16)26-10-5-6-14-15(7-10)25-9-24-14/h1-9H,(H,24,25)(H2,23,26,27,28) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Similars AffyNet 
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Georgetown University
Curated by ChEMBL
| Assay Description Inhibition of CDK1 |
AAPS J 8: 204-21 (2006)
|
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (human)) | BDBM50214108
 (CHEMBL248712 | N-((5-(3-(5,6-difluoro-1H-benzo[d]i...)Show SMILES CCNCc1cncc(c1)-c1cnc2n[nH]c(-c3nc4cc(F)c(F)cc4[nH]3)c2c1 Show InChI InChI=1S/C21H17F2N7/c1-2-24-7-11-3-12(9-25-8-11)13-4-14-19(29-30-20(14)26-10-13)21-27-17-5-15(22)16(23)6-18(17)28-21/h3-6,8-10,24H,2,7H2,1H3,(H,27,28)(H,26,29,30) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Patents
Similars AffyNet 
| Article PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development L.L.C.
Curated by ChEMBL
| Assay Description Inhibition of CDK1 |
Bioorg Med Chem Lett 17: 4297-302 (2007)
|
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (human)) | BDBM2579
 ((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
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CHEMBL MMDB PC cid PC sid UniChem
Patents
Similars AffyNet 
| Article PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
National Cancer Institute
Curated by ChEMBL
| Assay Description Inhibition of CDK1/cyclinB |
J Med Chem 52: 3191-204 (2009)
|
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (human)) | BDBM50214100
 (CHEMBL249303 | N-ethyl-N-((2-(5-(isoquinolin-4-yl)...)Show SMILES CCN(CC)Cc1cccc2nc([nH]c12)-c1n[nH]c2ncc(cc12)-c1cncc2ccccc12 Show InChI InChI=1S/C27H25N7/c1-3-34(4-2)16-18-9-7-11-23-24(18)31-27(30-23)25-21-12-19(14-29-26(21)33-32-25)22-15-28-13-17-8-5-6-10-20(17)22/h5-15H,3-4,16H2,1-2H3,(H,30,31)(H,29,32,33) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Patents
Similars AffyNet 
| Article PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development L.L.C.
Curated by ChEMBL
| Assay Description Inhibition of CDK1 |
Bioorg Med Chem Lett 17: 4297-302 (2007)
|
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (human)) | BDBM50246408
 ((4-(5-fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5...)Show SMILES CN[C@H]1CCN(C1)C(=O)c1ccc(Nc2ncc(F)c(n2)-c2cnc(C)n2C(C)C)cc1 Show InChI InChI=1S/C23H28FN7O/c1-14(2)31-15(3)26-12-20(31)21-19(24)11-27-23(29-21)28-17-7-5-16(6-8-17)22(32)30-10-9-18(13-30)25-4/h5-8,11-12,14,18,25H,9-10,13H2,1-4H3,(H,27,28,29)/t18-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL PC cid PC sid UniChem
Similars AffyNet 
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of CDK1 (unknown origin) |
Bioorg Med Chem Lett 18: 6369-73 (2008)
|
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (human)) | BDBM50164726
 ((3H-Benzoimidazol-5-yl)-(4-isobutoxy-5-trifluorome...)Show InChI InChI=1S/C16H16F3N5O/c1-9(2)7-25-14-11(16(17,18)19)6-20-15(24-14)23-10-3-4-12-13(5-10)22-8-21-12/h3-6,8-9H,7H2,1-2H3,(H,21,22)(H,20,23,24) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Similars AffyNet 
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description Inhibitory concentration against Cyclin dependent kinase 1 |
Bioorg Med Chem Lett 15: 1973-7 (2005)
|
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (human)) | BDBM2492
 (US8507510, 1.25 | US8507510, 1.27)Show SMILES COc1cc(Nc2ncc(Br)c(N[C@H](C)[C@H](C)O)n2)ccc1S(C)(=N)=O Show InChI InChI=1S/C16H22BrN5O3S/c1-9(10(2)23)20-15-12(17)8-19-16(22-15)21-11-5-6-14(26(4,18)24)13(7-11)25-3/h5-10,18,23H,1-4H3,(H2,19,20,21,22)/t9-,10+,26?/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| PC cid PC sid UniChem
Similars AffyNet 
| US Patent
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Intellectual Property GmbH
US Patent
| Assay Description Kinase assay using either CDK1, CDK2 or VEGFR-2. |
US Patent US8507510 (2013)
|
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (human)) | BDBM2491
 (US8507510, 1.26)Show SMILES COc1cc(Nc2ncc(Br)c(N[C@H](C)[C@@H](C)O)n2)ccc1S(C)(=N)=O Show InChI InChI=1S/C16H22BrN5O3S/c1-9(10(2)23)20-15-12(17)8-19-16(22-15)21-11-5-6-14(26(4,18)24)13(7-11)25-3/h5-10,18,23H,1-4H3,(H2,19,20,21,22)/t9-,10-,26?/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| PC cid PC sid UniChem
Similars AffyNet 
| US Patent
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Intellectual Property GmbH
US Patent
| Assay Description Kinase assay using either CDK1, CDK2 or VEGFR-2. |
US Patent US8507510 (2013)
|
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (human)) | BDBM2544
 (US8507510, 1.23 | US8507510, 1.41)Show SMILES COc1cc(Nc2ncc(Br)c(N[C@H](C)C(C)(C)O)n2)ccc1S(C)(=N)=O Show InChI InChI=1S/C17H24BrN5O3S/c1-10(17(2,3)24)21-15-12(18)9-20-16(23-15)22-11-6-7-14(27(5,19)25)13(8-11)26-4/h6-10,19,24H,1-5H3,(H2,20,21,22,23)/t10-,27?/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| PC cid PC sid UniChem
Similars AffyNet 
| US Patent
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Intellectual Property GmbH
US Patent
| Assay Description Kinase assay using either CDK1, CDK2 or VEGFR-2. |
US Patent US8507510 (2013)
|
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (human)) | BDBM50214107
 ((5-(3-(4-(methoxymethyl)-1H-benzo[d]imidazol-2-yl)...)Show SMILES CNCc1cncc(c1)-c1cnc2n[nH]c(-c3nc4cccc(COC)c4[nH]3)c2c1 Show InChI InChI=1S/C22H21N7O/c1-23-8-13-6-15(10-24-9-13)16-7-17-20(28-29-21(17)25-11-16)22-26-18-5-3-4-14(12-30-2)19(18)27-22/h3-7,9-11,23H,8,12H2,1-2H3,(H,26,27)(H,25,28,29) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Similars AffyNet 
| Article PubMed
| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development L.L.C.
Curated by ChEMBL
| Assay Description Inhibition of CDK1 |
Bioorg Med Chem Lett 17: 4297-302 (2007)
|
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (human)) | BDBM7720
 ((3Z)-2-oxo-3-[2-(4-sulfamoylphenyl)hydrazin-1-ylid...)Show SMILES NC(=O)c1ccc2NC(=O)C(=NNc3ccc(cc3)S(N)(=O)=O)c2c1 Show InChI InChI=1S/C15H13N5O4S/c16-14(21)8-1-6-12-11(7-8)13(15(22)18-12)20-19-9-2-4-10(5-3-9)25(17,23)24/h1-7,19H,(H2,16,21)(H2,17,23,24)(H,18,20,22) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| PC cid PC sid UniChem
Patents
Similars AffyNet 
| Article PubMed
| n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich
Curated by ChEMBL
| Assay Description Inhibition of CDK1 |
J Med Chem 51: 1179-88 (2008)
|
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (human)) | BDBM50384172
 (CHEMBL2029900)Show SMILES CN1CCN(CC1)C(=O)c1cc(Nc2ncc3cc(CN=O)n(C4CCCC4)c3n2)cn1C Show InChI InChI=1S/C23H30N8O2/c1-28-7-9-30(10-8-28)22(32)20-12-17(15-29(20)2)26-23-24-13-16-11-19(14-25-33)31(21(16)27-23)18-5-3-4-6-18/h11-13,15,18H,3-10,14H2,1-2H3,(H,24,26,27) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Similars AffyNet 
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Biogen Idec Inc.
Curated by ChEMBL
| Assay Description Inhibition of CDK1 |
Bioorg Med Chem Lett 22: 4033-7 (2012)
|
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (human)) | BDBM50164724
 (CHEMBL193922 | N*2*-(3H-Benzoimidazol-5-yl)-N*4*-(...)Show SMILES FC(F)(F)c1cnc(Nc2ccc3nc[nH]c3c2)nc1Nc1cccc(Cl)c1 Show InChI InChI=1S/C18H12ClF3N6/c19-10-2-1-3-11(6-10)26-16-13(18(20,21)22)8-23-17(28-16)27-12-4-5-14-15(7-12)25-9-24-14/h1-9H,(H,24,25)(H2,23,26,27,28) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
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Similars AffyNet 
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description Inhibitory concentration against Cyclin dependent kinase 1 |
Bioorg Med Chem Lett 15: 1973-7 (2005)
|
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (human)) | BDBM50214099
 (CHEMBL400569 | N-((5-(3-(5-(4-methylpiperazin-1-yl...)Show SMILES CCNCc1cncc(c1)-c1cnc2[nH]nc(-c3nc4ccc(cc4[nH]3)N3CCN(C)CC3)c2c1 Show InChI InChI=1S/C26H29N9/c1-3-27-13-17-10-18(15-28-14-17)19-11-21-24(32-33-25(21)29-16-19)26-30-22-5-4-20(12-23(22)31-26)35-8-6-34(2)7-9-35/h4-5,10-12,14-16,27H,3,6-9,13H2,1-2H3,(H,30,31)(H,29,32,33) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Similars AffyNet 
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development L.L.C.
Curated by ChEMBL
| Assay Description Inhibition of CDK1 |
Bioorg Med Chem Lett 17: 4297-302 (2007)
|
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (human)) | BDBM2492
 (US8507510, 1.25 | US8507510, 1.27)Show SMILES COc1cc(Nc2ncc(Br)c(N[C@H](C)[C@H](C)O)n2)ccc1S(C)(=N)=O Show InChI InChI=1S/C16H22BrN5O3S/c1-9(10(2)23)20-15-12(17)8-19-16(22-15)21-11-5-6-14(26(4,18)24)13(7-11)25-3/h5-10,18,23H,1-4H3,(H2,19,20,21,22)/t9-,10+,26?/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| PC cid PC sid UniChem
Similars AffyNet 
| US Patent
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Intellectual Property GmbH
US Patent
| Assay Description Kinase assay using either CDK1, CDK2 or VEGFR-2. |
US Patent US8507510 (2013)
|
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (human)) | BDBM129353
 (US8802686, 11)Show SMILES C[C@@H](O)[C@@H](C)Oc1nc(Nc2ccc(cc2)S(=O)(=O)CCO)ncc1C(F)(F)F Show InChI InChI=1S/C17H20F3N3O5S/c1-10(25)11(2)28-15-14(17(18,19)20)9-21-16(23-15)22-12-3-5-13(6-4-12)29(26,27)8-7-24/h3-6,9-11,24-25H,7-8H2,1-2H3,(H,21,22,23)/t10-,11-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
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Similars AffyNet 
| US Patent
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Intellectual Property GmbH
US Patent
| Assay Description CDK1/CycB (200 ng/measuring point) was incubated for 10 min at 22 C. in the presence of different concentrations of test substances (0 and within the... |
US Patent US8802686 (2014)
|
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (human)) | BDBM2457
 (US8507510, 1.18)Show SMILES C[C@@H](O)[C@@H](C)Nc1nc(Nc2ccc(cc2)S(=N)(=O)CCO)ncc1Br Show InChI InChI=1S/C16H22BrN5O3S/c1-10(11(2)24)20-15-14(17)9-19-16(22-15)21-12-3-5-13(6-4-12)26(18,25)8-7-23/h3-6,9-11,18,23-24H,7-8H2,1-2H3,(H2,19,20,21,22)/t10-,11-,26?/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
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Similars AffyNet 
| US Patent
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Intellectual Property GmbH
US Patent
| Assay Description Kinase assay using either CDK1, CDK2 or VEGFR-2. |
US Patent US8507510 (2013)
|
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (human)) | BDBM2579
 ((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL MMDB PC cid PC sid UniChem
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Similars AffyNet 
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| n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Illinois at Chicago
Curated by ChEMBL
| Assay Description Inhibition of CDK1/Cyclin B |
J Med Chem 52: 1853-63 (2009)
|
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (human)) | BDBM50164706
 ((3H-Benzoimidazol-5-yl)-(4-o-tolyloxy-5-trifluorom...)Show SMILES Cc1ccccc1Oc1nc(Nc2ccc3nc[nH]c3c2)ncc1C(F)(F)F Show InChI InChI=1S/C19H14F3N5O/c1-11-4-2-3-5-16(11)28-17-13(19(20,21)22)9-23-18(27-17)26-12-6-7-14-15(8-12)25-10-24-14/h2-10H,1H3,(H,24,25)(H,23,26,27) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Similars AffyNet 
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description Inhibitory concentration against Cyclin dependent kinase 1 |
Bioorg Med Chem Lett 15: 1973-7 (2005)
|
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (human)) | BDBM50164711
 (CHEMBL195423 | N*2*-(3H-Benzoimidazol-5-yl)-5-brom...)Show InChI InChI=1S/C17H12BrFN6/c18-13-8-20-17(24-12-5-6-14-15(7-12)22-9-21-14)25-16(13)23-11-3-1-10(19)2-4-11/h1-9H,(H,21,22)(H2,20,23,24,25) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Similars AffyNet 
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description Inhibitory concentration against Cyclin dependent kinase 1 |
Bioorg Med Chem Lett 15: 1973-7 (2005)
|
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (human)) | BDBM50164725
 (CHEMBL193367 | N*2*-(3H-Benzoimidazol-5-yl)-N*4*-(...)Show SMILES FC(F)(F)c1cnc(Nc2ccc3nc[nH]c3c2)nc1Nc1ccc(Cl)cc1 Show InChI InChI=1S/C18H12ClF3N6/c19-10-1-3-11(4-2-10)26-16-13(18(20,21)22)8-23-17(28-16)27-12-5-6-14-15(7-12)25-9-24-14/h1-9H,(H,24,25)(H2,23,26,27,28) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Similars AffyNet 
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description Inhibitory concentration against Cyclin dependent kinase 1 |
Bioorg Med Chem Lett 15: 1973-7 (2005)
|
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (human)) | BDBM100907
 (US8507510, 1.60)Show SMILES C[C@H](O)[C@@H](C)Nc1nc(Nc2ccc(c(C)c2)S(C)(=N)=O)ncc1Br Show InChI InChI=1S/C16H22BrN5O2S/c1-9-7-12(5-6-14(9)25(4,18)24)21-16-19-8-13(17)15(22-16)20-10(2)11(3)23/h5-8,10-11,18,23H,1-4H3,(H2,19,20,21,22)/t10-,11+,25?/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| PC cid PC sid UniChem
Similars AffyNet 
| US Patent
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Intellectual Property GmbH
US Patent
| Assay Description Kinase assay using either CDK1, CDK2 or VEGFR-2. |
US Patent US8507510 (2013)
|
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (human)) | BDBM2578
 (US8507510, 1.57 | US8507510, 1.58)Show SMILES C[C@@H](Nc1nc(Nc2ccc(c(C)c2)S(C)(=N)=O)ncc1Br)C(C)(C)O Show InChI InChI=1S/C17H24BrN5O2S/c1-10-8-12(6-7-14(10)26(5,19)25)22-16-20-9-13(18)15(23-16)21-11(2)17(3,4)24/h6-9,11,19,24H,1-5H3,(H2,20,21,22,23)/t11-,26?/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| PC cid PC sid UniChem
Similars AffyNet 
| US Patent
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Intellectual Property GmbH
US Patent
| Assay Description Kinase assay using either CDK1, CDK2 or VEGFR-2. |
US Patent US8507510 (2013)
|
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (human)) | BDBM6145
 (US8802686, 2 | US8802686, C2)Show SMILES C[C@@H](O)[C@@H](C)Oc1nc(Nc2ccc(cc2)S(C)(=O)=O)ncc1C(F)(F)F Show InChI InChI=1S/C16H18F3N3O4S/c1-9(23)10(2)26-14-13(16(17,18)19)8-20-15(22-14)21-11-4-6-12(7-5-11)27(3,24)25/h4-10,23H,1-3H3,(H,20,21,22)/t9-,10-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| PC cid PC sid UniChem
Similars AffyNet 
| US Patent
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Intellectual Property GmbH
US Patent
| Assay Description CDK1/CycB (200 ng/measuring point) was incubated for 10 min at 22 C. in the presence of different concentrations of test substances (0 and within the... |
US Patent US8802686 (2014)
|
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (human)) | BDBM27216
 ((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)Show SMILES CC(C)[C@H](CO)Nc1nc(Nc2cccc(Cl)c2)c2ncn(C(C)C)c2n1 Show InChI InChI=1S/C19H25ClN6O/c1-11(2)15(9-27)23-19-24-17(22-14-7-5-6-13(20)8-14)16-18(25-19)26(10-21-16)12(3)4/h5-8,10-12,15,27H,9H2,1-4H3,(H2,22,23,24,25)/t15-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
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Patents
Similars AffyNet 
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| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description Inhibition of human cdc2/cyclin B assessed as [32P] incorporation in histone H1 from [gamma32P]ATP |
Science 281: 533-538 (1998)
|
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (human)) | BDBM50245910
 ((4-(5-fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5...)Show SMILES CC(C)n1c(C)ncc1-c1nc(Nc2ccc(cc2)C(=O)N2CCCN(C)CC2)ncc1F Show InChI InChI=1S/C24H30FN7O/c1-16(2)32-17(3)26-15-21(32)22-20(25)14-27-24(29-22)28-19-8-6-18(7-9-19)23(33)31-11-5-10-30(4)12-13-31/h6-9,14-16H,5,10-13H2,1-4H3,(H,27,28,29) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
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Similars AffyNet 
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of CDK1 (unknown origin) |
Bioorg Med Chem Lett 18: 6369-73 (2008)
|
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (human)) | BDBM50297121
 ((R)-9-Methyl-1,2,8,9,10,11-hexahydro-3-oxa-6-thia-...)Show InChI InChI=1S/C14H14N2O2S/c1-7-6-15-12-11-8-4-5-18-9(8)2-3-10(11)19-13(12)14(17)16-7/h2-3,7,15H,4-6H2,1H3,(H,16,17)/t7-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
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Similars AffyNet 
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of CDK2 |
Bioorg Med Chem Lett 19: 4882-4 (2009)
|
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (human)) | BDBM7646
 (CHEMBL102926 | Imidazo[1,2-a]pyridine deriv. 6 | N...)Show SMILES CN(C)CC(O)COc1ccc(Nc2nccc(n2)-c2c(C)nc3ccccn23)cc1 Show InChI InChI=1S/C23H26N6O2/c1-16-22(29-13-5-4-6-21(29)25-16)20-11-12-24-23(27-20)26-17-7-9-19(10-8-17)31-15-18(30)14-28(2)3/h4-13,18,30H,14-15H2,1-3H3,(H,24,26,27) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid PDB UniChem
Similars AffyNet 
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Georgetown University
Curated by ChEMBL
| Assay Description Inhibition of CDK1 |
AAPS J 8: 204-21 (2006)
|
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (human)) | BDBM100882
 (US8507510, 1.9)Show SMILES C[C@@H](Nc1nc(Nc2ccc(cc2)S(=N)(=O)CC2CC2)ncc1Br)C(C)(C)O Show InChI InChI=1S/C19H26BrN5O2S/c1-12(19(2,3)26)23-17-16(20)10-22-18(25-17)24-14-6-8-15(9-7-14)28(21,27)11-13-4-5-13/h6-10,12-13,21,26H,4-5,11H2,1-3H3,(H2,22,23,24,25)/t12-,28?/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| PC cid PC sid UniChem
Similars AffyNet 
| US Patent
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Intellectual Property GmbH
US Patent
| Assay Description Kinase assay using either CDK1, CDK2 or VEGFR-2. |
US Patent US8507510 (2013)
|
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (human)) | BDBM50375644
 (CHEMBL440411)Show SMILES OS(=O)(=O)c1ccc2NC(=O)C(c2c1)c1[nH]c2ccccc2c1N=O Show InChI InChI=1S/C16H11N3O5S/c20-16-13(10-7-8(25(22,23)24)5-6-12(10)18-16)15-14(19-21)9-3-1-2-4-11(9)17-15/h1-7,13,17H,(H,18,20)(H,22,23,24) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
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Similars AffyNet 
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description Inhibition of Cdk1 |
Proc Natl Acad Sci USA 104: 20523-8 (2007)
Checked by Author |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (human)) | BDBM50005298
 (CHEMBL337300)Show InChI InChI=1S/C16H10IN3O2/c17-8-5-6-12-10(7-8)13(16(21)19-12)15-14(20-22)9-3-1-2-4-11(9)18-15/h1-7,18-19,21H | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
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Patents
Similars AffyNet 
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description Inhibition of Cdk1 |
Proc Natl Acad Sci USA 104: 20523-8 (2007)
Checked by Author |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (human)) | BDBM100904
 (US8507510, 1.51)Show SMILES CCS(=N)(=O)c1ccc(Nc2ncc(Br)c(N[C@H](C)[C@H](C)O)n2)cc1 Show InChI InChI=1S/C16H22BrN5O2S/c1-4-25(18,24)13-7-5-12(6-8-13)21-16-19-9-14(17)15(22-16)20-10(2)11(3)23/h5-11,18,23H,4H2,1-3H3,(H2,19,20,21,22)/t10-,11+,25?/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| PC cid PC sid UniChem
Similars AffyNet 
| US Patent
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Intellectual Property GmbH
US Patent
| Assay Description Kinase assay using either CDK1, CDK2 or VEGFR-2. |
US Patent US8507510 (2013)
|
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (human)) | BDBM2553
 (US8507510, 1.44)Show SMILES C[C@H](O)[C@@H](C)Nc1nc(Nc2ccc(cc2)S(C)(=N)=O)ncc1Br Show InChI InChI=1S/C15H20BrN5O2S/c1-9(10(2)22)19-14-13(16)8-18-15(21-14)20-11-4-6-12(7-5-11)24(3,17)23/h4-10,17,22H,1-3H3,(H2,18,19,20,21)/t9-,10+,24?/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| PC cid PC sid UniChem
Similars AffyNet 
| US Patent
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Intellectual Property GmbH
US Patent
| Assay Description Kinase assay using either CDK1, CDK2 or VEGFR-2. |
US Patent US8507510 (2013)
|
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (human)) | BDBM2489
 (US8507510, 1.19 | US8507510, 1.21)Show SMILES C[C@H](O)[C@@H](C)Nc1nc(Nc2ccc(cc2)S(=N)(=O)CCO)ncc1Br Show InChI InChI=1S/C16H22BrN5O3S/c1-10(11(2)24)20-15-14(17)9-19-16(22-15)21-12-3-5-13(6-4-12)26(18,25)8-7-23/h3-6,9-11,18,23-24H,7-8H2,1-2H3,(H2,19,20,21,22)/t10-,11+,26?/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| PC cid PC sid UniChem
Similars AffyNet 
| US Patent
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Intellectual Property GmbH
US Patent
| Assay Description Kinase assay using either CDK1, CDK2 or VEGFR-2. |
US Patent US8507510 (2013)
|
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (human)) | BDBM2546
 (US8507510, 1.42)Show SMILES C[C@H](Nc1nc(Nc2ccc(cc2)S(C)(=N)=O)ncc1Br)C(C)(C)O Show InChI InChI=1S/C16H22BrN5O2S/c1-10(16(2,3)23)20-14-13(17)9-19-15(22-14)21-11-5-7-12(8-6-11)25(4,18)24/h5-10,18,23H,1-4H3,(H2,19,20,21,22)/t10-,25?/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| PC cid PC sid UniChem
Similars AffyNet 
| US Patent
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Intellectual Property GmbH
US Patent
| Assay Description Kinase assay using either CDK1, CDK2 or VEGFR-2. |
US Patent US8507510 (2013)
|
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (human)) | BDBM100890
 (US8507510, 1.24)Show SMILES COc1cc(Nc2ncc(Br)c(O[C@H](C)[C@H](C)O)n2)ccc1S(C)(=N)=O Show InChI InChI=1S/C16H21BrN4O4S/c1-9(22)10(2)25-15-12(17)8-19-16(21-15)20-11-5-6-14(26(4,18)23)13(7-11)24-3/h5-10,18,22H,1-4H3,(H,19,20,21)/t9-,10+,26?/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| PC cid PC sid UniChem
Similars AffyNet 
| US Patent
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Intellectual Property GmbH
US Patent
| Assay Description Kinase assay using either CDK1, CDK2 or VEGFR-2. |
US Patent US8507510 (2013)
|
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (human)) | BDBM65549
 (3-[[4-[2-(3-chloroanilino)-4-pyrimidinyl]-2-pyridi...)Show InChI InChI=1S/C18H18ClN5O/c19-14-3-1-4-15(12-14)23-18-22-9-6-16(24-18)13-5-8-21-17(11-13)20-7-2-10-25/h1,3-6,8-9,11-12,25H,2,7,10H2,(H,20,21)(H,22,23,24) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| Purchase
PC cid PC sid UniChem
Similars AffyNet 
| Article PubMed
| n/a | n/a | <5.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of CDK1 |
Bioorg Med Chem Lett 22: 6636-41 (2012)
|
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (human)) | BDBM50214111
 (4-(3-(4-(methoxymethyl)-1H-benzo[d]imidazol-2-yl)-...)Show SMILES COCc1cccc2nc([nH]c12)-c1[nH]nc2ncc(cc12)-c1cncc2ccccc12 Show InChI InChI=1S/C24H18N6O/c1-31-13-15-6-4-8-20-21(15)28-24(27-20)22-18-9-16(11-26-23(18)30-29-22)19-12-25-10-14-5-2-3-7-17(14)19/h2-12H,13H2,1H3,(H,27,28)(H,26,29,30) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Patents
Similars AffyNet 
| Article PubMed
| n/a | n/a | 5.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development L.L.C.
Curated by ChEMBL
| Assay Description Inhibition of CDK1 |
Bioorg Med Chem Lett 17: 4297-302 (2007)
|
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (human)) | BDBM6866
 (1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...)Show SMILES Nc1nc(Nc2ccc(cc2)S(N)(=O)=O)nn1C(=O)c1c(F)cccc1F Show InChI InChI=1S/C15H12F2N6O3S/c16-10-2-1-3-11(17)12(10)13(24)23-14(18)21-15(22-23)20-8-4-6-9(7-5-8)27(19,25)26/h1-7H,(H2,19,25,26)(H3,18,20,21,22) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| Purchase
CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
Similars AffyNet 
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development LLC
Curated by ChEMBL
| Assay Description Inhibition of CDK1 |
Bioorg Med Chem Lett 16: 3639-41 (2006)
|
More data for this Ligand-Target Pair | |