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Compile Data Set for Download or QSAR

Found 115 hits Enz. Inhib. hit(s) with Target = 'LTB4R'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leukotriene B4 receptor 2


(Homo sapiens)
BDBM50472434
PNG
(CHEMBL2112887)
Show SMILES CN(C)C(=O)C[C@]1(O)CCC[C@@H](C1)\C=C\[C@@H](O)CCCCc1ccccc1
Show InChI InChI=1S/C23H35NO3/c1-24(2)22(26)18-23(27)16-8-12-20(17-23)14-15-21(25)13-7-6-11-19-9-4-3-5-10-19/h3-5,9-10,14-15,20-21,25,27H,6-8,11-13,16-18H2,1-2H3/b15-14+/t20-,21+,23+/m1/s1
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n/an/a 40n/an/an/an/an/an/a



CNRS 5074

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]LTB4 (1 nM) to intact human polymorphonuclear leukocytes (PMNs)


J Med Chem 42: 5289-310 (1999)

More data for this
Ligand-Target Pair
Leukotriene B4 receptor 2


(Homo sapiens)
BDBM50472441
PNG
(CHEMBL153555)
Show SMILES CN(C)OC(=O)C[C@@]1(O)CCC[C@@H](C1)\C=C\C(O)CCCCc1ccccc1
Show InChI InChI=1S/C23H35NO4/c1-24(2)28-22(26)18-23(27)16-8-12-20(17-23)14-15-21(25)13-7-6-11-19-9-4-3-5-10-19/h3-5,9-10,14-15,20-21,25,27H,6-8,11-13,16-18H2,1-2H3/b15-14+/t20-,21?,23-/m1/s1
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n/an/a 80n/an/an/an/an/an/a



CNRS 5074

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]LTB4 (1 nM) to intact human polymorphonuclear leukocytes (PMNs)


J Med Chem 42: 5289-310 (1999)

More data for this
Ligand-Target Pair
Leukotriene 2


(Homo sapiens (Human))
BDBM50317628
PNG
(4-{2-(2-Carboxy-ethyl)-3-[6-(3,5-di-pyridin-4-yl-p...)
Show SMILES OC(=O)CCCOc1cccc(CCCCCCOc2cc(cc(c2)-c2ccncc2)-c2ccncc2)c1CCC(O)=O
Show InChI InChI=1S/C35H38N2O6/c38-34(39)10-6-22-43-33-9-5-8-28(32(33)11-12-35(40)41)7-3-1-2-4-21-42-31-24-29(26-13-17-36-18-14-26)23-30(25-31)27-15-19-37-20-16-27/h5,8-9,13-20,23-25H,1-4,6-7,10-12,21-22H2,(H,38,39)(H,40,41)
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n/an/a 143n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
Antagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization prein...


J Med Chem 53: 3502-16 (2010)


Article DOI: 10.1021/jm1001919
BindingDB Entry DOI: 10.7270/Q2KW5G67
More data for this
Ligand-Target Pair
Leukotriene 2


(Homo sapiens (Human))
BDBM50317626
PNG
(4-{3-[6-(3-5-Benzo[1,3]dioxolyl-5-thiophen-3-ylphe...)
Show SMILES OC(=O)CCCOc1cccc(CCCCCCOc2cc(cc(c2)-c2ccc3OCOc3c2)-c2ccsc2)c1CCC(O)=O
Show InChI InChI=1S/C36H38O8S/c37-35(38)10-6-17-42-32-9-5-8-25(31(32)12-14-36(39)40)7-3-1-2-4-16-41-30-20-28(19-29(21-30)27-15-18-45-23-27)26-11-13-33-34(22-26)44-24-43-33/h5,8-9,11,13,15,18-23H,1-4,6-7,10,12,14,16-17,24H2,(H,37,38)(H,39,40)
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n/an/a 164n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
Antagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization prein...


J Med Chem 53: 3502-16 (2010)


Article DOI: 10.1021/jm1001919
BindingDB Entry DOI: 10.7270/Q2KW5G67
More data for this
Ligand-Target Pair
Leukotriene 2


(Homo sapiens (Human))
BDBM50317623
PNG
(4-(3-(6-(5-(benzo[d][1,3]dioxol-5-yl)-3'-fluorobip...)
Show SMILES OC(=O)CCCOc1cccc(CCCCCCOc2cc(cc(c2)-c2cccc(F)c2)-c2ccc3OCOc3c2)c1CCC(O)=O
Show InChI InChI=1S/C38H39FO8/c39-31-11-5-10-27(21-31)29-20-30(28-14-16-35-36(24-28)47-25-46-35)23-32(22-29)44-18-4-2-1-3-8-26-9-6-12-34(33(26)15-17-38(42)43)45-19-7-13-37(40)41/h5-6,9-12,14,16,20-24H,1-4,7-8,13,15,17-19,25H2,(H,40,41)(H,42,43)
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n/an/a 194n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
Antagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization prein...


J Med Chem 53: 3502-16 (2010)


Article DOI: 10.1021/jm1001919
BindingDB Entry DOI: 10.7270/Q2KW5G67
More data for this
Ligand-Target Pair
Leukotriene B4 receptor 2


(Homo sapiens)
BDBM50472436
PNG
(CHEMBL2112037)
Show SMILES [Na+].O[C@@H](CCCCc1ccccc1)\C=C\[C@H]1CCC[C@](O)(C1)C([O-])=O
Show InChI InChI=1S/C20H28O4.Na/c21-18(11-5-4-9-16-7-2-1-3-8-16)13-12-17-10-6-14-20(24,15-17)19(22)23;/h1-3,7-8,12-13,17-18,21,24H,4-6,9-11,14-15H2,(H,22,23);/q;+1/p-1/b13-12+;/t17-,18+,20+;/m1./s1
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n/an/a 250n/an/an/an/an/an/a



CNRS 5074

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]LTB4 (1 nM) to intact human polymorphonuclear leukocytes (PMNs)


J Med Chem 42: 5289-310 (1999)

More data for this
Ligand-Target Pair
Leukotriene B4 receptor 2


(Homo sapiens)
BDBM50472428
PNG
(CHEMBL345517)
Show SMILES [Na+].OC(CCCCc1ccccc1)\C=C\[C@H]1CCC\C(C1)=C\C([O-])=O
Show InChI InChI=1S/C21H28O3.Na/c22-20(12-5-4-9-17-7-2-1-3-8-17)14-13-18-10-6-11-19(15-18)16-21(23)24;/h1-3,7-8,13-14,16,18,20,22H,4-6,9-12,15H2,(H,23,24);/q;+1/p-1/b14-13+,19-16-;/t18-,20?;/m1./s1
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n/an/a 500n/an/an/an/an/an/a



CNRS 5074

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]LTB4 (1 nM) to intact human polymorphonuclear leukocytes (PMNs)


J Med Chem 42: 5289-310 (1999)

More data for this
Ligand-Target Pair
Leukotriene 2


(Homo sapiens (Human))
BDBM50317625
PNG
(4-{2-(2-Carboxyethyl)-3-[6-([1,1',3,1'']terphenyl-...)
Show SMILES OC(=O)CCCOc1cccc(CCCCCCOc2cc(cc(c2)-c2ccccc2)-c2ccccc2)c1CCC(O)=O
Show InChI InChI=1S/C37H40O6/c38-36(39)20-12-24-43-35-19-11-18-30(34(35)21-22-37(40)41)17-5-1-2-10-23-42-33-26-31(28-13-6-3-7-14-28)25-32(27-33)29-15-8-4-9-16-29/h3-4,6-9,11,13-16,18-19,25-27H,1-2,5,10,12,17,20-24H2,(H,38,39)(H,40,41)
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n/an/a 628n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
Antagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization prein...


J Med Chem 53: 3502-16 (2010)


Article DOI: 10.1021/jm1001919
BindingDB Entry DOI: 10.7270/Q2KW5G67
More data for this
Ligand-Target Pair
Leukotriene B4 receptor 2


(Homo sapiens)
BDBM50476608
PNG
(CHEMBL241946)
Show SMILES CN(CCc1ccc(C)cc1)C(=O)Cc1ccc(OCCCCOc2ccc(CC(O)=O)cc2)cc1
Show InChI InChI=1S/C30H35NO5/c1-23-5-7-24(8-6-23)17-18-31(2)29(32)21-25-9-13-27(14-10-25)35-19-3-4-20-36-28-15-11-26(12-16-28)22-30(33)34/h5-16H,3-4,17-22H2,1-2H3,(H,33,34)
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n/an/a 660n/an/an/an/an/an/a



Zentiva VUFB, a.s.

Curated by ChEMBL


Assay Description
Displacement of [3H]LTB4 from LTB4 receptor in guinea pig spleen membrane


Eur J Med Chem 42: 1084-94 (2007)

More data for this
Ligand-Target Pair
Leukotriene B4 receptor 2


(Homo sapiens)
BDBM50084106
PNG
(CHEMBL77513 | Sodium; [(1S,3S)-1-hydroxy-3-((E)-3-...)
Show SMILES OC(CCCCc1ccccc1)\C=C\[C@H]1CCC[C@@](O)(CC([O-])=O)C1
Show InChI InChI=1S/C21H30O4/c22-19(11-5-4-9-17-7-2-1-3-8-17)13-12-18-10-6-14-21(25,15-18)16-20(23)24/h1-3,7-8,12-13,18-19,22,25H,4-6,9-11,14-16H2,(H,23,24)/p-1/b13-12+/t18-,19?,21+/m1/s1
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n/an/a 800n/an/an/an/an/an/a



CNRS 5074

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]LTB4 (1 nM) to intact human polymorphonuclear leukocytes (PMNs)


J Med Chem 42: 5289-310 (1999)

More data for this
Ligand-Target Pair
Leukotriene B4 receptor 2


(Homo sapiens)
BDBM50084101
PNG
(CHEMBL80541 | Sodium; [(1S,3S)-1-hydroxy-3-((E)-3-...)
Show SMILES CCCCCCCCC(O)\C=C\[C@H]1CCC[C@@](O)(CC([O-])=O)C1
Show InChI InChI=1S/C19H34O4/c1-2-3-4-5-6-7-10-17(20)12-11-16-9-8-13-19(23,14-16)15-18(21)22/h11-12,16-17,20,23H,2-10,13-15H2,1H3,(H,21,22)/p-1/b12-11+/t16-,17?,19+/m1/s1
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n/an/a 900n/an/an/an/an/an/a



CNRS 5074

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]LTB4 (1 nM) to intact human polymorphonuclear leukocytes (PMNs)


J Med Chem 42: 5289-310 (1999)

More data for this
Ligand-Target Pair
Leukotriene B4 receptor 2


(Homo sapiens)
BDBM50472424
PNG
(CHEMBL151989)
Show SMILES CN(C)OC(=O)\C=C1\CCC[C@H](C1)\C=C\C(O)CCCCc1ccccc1
Show InChI InChI=1S/C23H33NO3/c1-24(2)27-23(26)18-21-13-8-12-20(17-21)15-16-22(25)14-7-6-11-19-9-4-3-5-10-19/h3-5,9-10,15-16,18,20,22,25H,6-8,11-14,17H2,1-2H3/b16-15+,21-18-/t20-,22?/m0/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



CNRS 5074

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]LTB4 (1 nM) to intact human polymorphonuclear leukocytes (PMNs)


J Med Chem 42: 5289-310 (1999)

More data for this
Ligand-Target Pair
Leukotriene B4 receptor 2


(Homo sapiens)
BDBM50476604
PNG
(CHEMBL241945)
Show SMILES CN(CCc1cccc(C)c1)C(=O)Cc1ccc(OCCCCOc2ccc(CC(O)=O)cc2)cc1
Show InChI InChI=1S/C30H35NO5/c1-23-6-5-7-24(20-23)16-17-31(2)29(32)21-25-8-12-27(13-9-25)35-18-3-4-19-36-28-14-10-26(11-15-28)22-30(33)34/h5-15,20H,3-4,16-19,21-22H2,1-2H3,(H,33,34)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Zentiva VUFB, a.s.

Curated by ChEMBL


Assay Description
Displacement of [3H]LTB4 from LTB4 receptor in guinea pig spleen membrane


Eur J Med Chem 42: 1084-94 (2007)

More data for this
Ligand-Target Pair
Leukotriene B4 receptor 2


(Homo sapiens)
BDBM50476603
PNG
(CHEMBL242574)
Show SMILES CN(CCc1ccccc1)C(=O)Cc1ccc(OCCCCOc2ccc(CC(O)=O)cc2Cl)cc1
Show InChI InChI=1S/C29H32ClNO5/c1-31(16-15-22-7-3-2-4-8-22)28(32)20-23-9-12-25(13-10-23)35-17-5-6-18-36-27-14-11-24(19-26(27)30)21-29(33)34/h2-4,7-14,19H,5-6,15-18,20-21H2,1H3,(H,33,34)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Zentiva VUFB, a.s.

Curated by ChEMBL


Assay Description
Displacement of [3H]LTB4 from LTB4 receptor in guinea pig spleen membrane


Eur J Med Chem 42: 1084-94 (2007)

More data for this
Ligand-Target Pair
Leukotriene B4 receptor 2


(Homo sapiens)
BDBM50472433
PNG
(CHEMBL151371)
Show SMILES [Na+].OC(CCCCc1ccccc1)\C=C/[C@H]1CCC\C(C1)=C/C([O-])=O
Show InChI InChI=1S/C21H28O3.Na/c22-20(12-5-4-9-17-7-2-1-3-8-17)14-13-18-10-6-11-19(15-18)16-21(23)24;/h1-3,7-8,13-14,16,18,20,22H,4-6,9-12,15H2,(H,23,24);/q;+1/p-1/b14-13-,19-16+;/t18-,20?;/m1./s1
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n/an/a 1.30E+3n/an/an/an/an/an/a



CNRS 5074

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]LTB4 (1 nM) to intact human polymorphonuclear leukocytes (PMNs)


J Med Chem 42: 5289-310 (1999)

More data for this
Ligand-Target Pair
Leukotriene B4 receptor 2


(Homo sapiens)
BDBM50472432
PNG
(CHEMBL358980)
Show SMILES [Na+].OC(CCCCc1ccccc1)\C=C\[C@H]1CCC[C@](O)(CC([O-])=O)C1
Show InChI InChI=1S/C21H30O4.Na/c22-19(11-5-4-9-17-7-2-1-3-8-17)13-12-18-10-6-14-21(25,15-18)16-20(23)24;/h1-3,7-8,12-13,18-19,22,25H,4-6,9-11,14-16H2,(H,23,24);/q;+1/p-1/b13-12+;/t18-,19?,21-;/m1./s1
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n/an/a 1.50E+3n/an/an/an/an/an/a



CNRS 5074

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]LTB4 (1 nM) to intact human polymorphonuclear leukocytes (PMNs)


J Med Chem 42: 5289-310 (1999)

More data for this
Ligand-Target Pair
Leukotriene B4 receptor 2


(Homo sapiens)
BDBM50476607
PNG
(CHEMBL242157)
Show SMILES CN(CCc1ccc(Br)cc1)C(=O)Cc1ccc(OCCCCOc2ccc(CC(O)=O)cc2)cc1
Show InChI InChI=1S/C29H32BrNO5/c1-31(17-16-22-4-10-25(30)11-5-22)28(32)20-23-6-12-26(13-7-23)35-18-2-3-19-36-27-14-8-24(9-15-27)21-29(33)34/h4-15H,2-3,16-21H2,1H3,(H,33,34)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Zentiva VUFB, a.s.

Curated by ChEMBL


Assay Description
Displacement of [3H]LTB4 from LTB4 receptor in guinea pig spleen membrane


Eur J Med Chem 42: 1084-94 (2007)

More data for this
Ligand-Target Pair
Leukotriene B4 receptor 2


(Homo sapiens)
BDBM50476610
PNG
(CHEMBL390870)
Show SMILES COc1cc(CC(O)=O)ccc1OCCCCOc1ccc(CC(=O)N(C)CCc2ccc(Br)cc2)cc1
Show InChI InChI=1S/C30H34BrNO6/c1-32(16-15-22-5-10-25(31)11-6-22)29(33)20-23-7-12-26(13-8-23)37-17-3-4-18-38-27-14-9-24(21-30(34)35)19-28(27)36-2/h5-14,19H,3-4,15-18,20-21H2,1-2H3,(H,34,35)
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n/an/a 1.90E+3n/an/an/an/an/an/a



Zentiva VUFB, a.s.

Curated by ChEMBL


Assay Description
Displacement of [3H]LTB4 from LTB4 receptor in guinea pig spleen membrane


Eur J Med Chem 42: 1084-94 (2007)

More data for this
Ligand-Target Pair
Leukotriene B4 receptor 2


(Homo sapiens)
BDBM50472423
PNG
(CHEMBL150744)
Show SMILES CN(C)C(=O)C[C@]1(O)CCC[C@@H](C1)\C=C\C(F)CCCCc1ccccc1
Show InChI InChI=1S/C23H34FNO2/c1-25(2)22(26)18-23(27)16-8-12-20(17-23)14-15-21(24)13-7-6-11-19-9-4-3-5-10-19/h3-5,9-10,14-15,20-21,27H,6-8,11-13,16-18H2,1-2H3/b15-14+/t20-,21?,23+/m1/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



CNRS 5074

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]LTB4 (1 nM) to intact human polymorphonuclear leukocytes (PMNs)


J Med Chem 42: 5289-310 (1999)

More data for this
Ligand-Target Pair
Leukotriene B4 receptor 2


(Homo sapiens)
BDBM50476609
PNG
(CHEMBL242369)
Show SMILES CN(CCc1ccccc1)C(=O)Cc1ccc(OCCCOc2ccc(CC(O)=O)cc2Cl)cc1
Show InChI InChI=1S/C28H30ClNO5/c1-30(15-14-21-6-3-2-4-7-21)27(31)19-22-8-11-24(12-9-22)34-16-5-17-35-26-13-10-23(18-25(26)29)20-28(32)33/h2-4,6-13,18H,5,14-17,19-20H2,1H3,(H,32,33)
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n/an/a 2.40E+3n/an/an/an/an/an/a



Zentiva VUFB, a.s.

Curated by ChEMBL


Assay Description
Displacement of [3H]LTB4 from LTB4 receptor in guinea pig spleen membrane


Eur J Med Chem 42: 1084-94 (2007)

More data for this
Ligand-Target Pair
Leukotriene B4 receptor 2


(Homo sapiens)
BDBM50472426
PNG
(CHEMBL150746)
Show SMILES [Na+].CCCCCCCCC(O)\C=C\[C@H]1CCC[C@](O)(CC([O-])=O)C1
Show InChI InChI=1S/C19H34O4.Na/c1-2-3-4-5-6-7-10-17(20)12-11-16-9-8-13-19(23,14-16)15-18(21)22;/h11-12,16-17,20,23H,2-10,13-15H2,1H3,(H,21,22);/q;+1/p-1/b12-11+;/t16-,17?,19-;/m1./s1
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n/an/a 2.50E+3n/an/an/an/an/an/a



CNRS 5074

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]LTB4 (1 nM) to intact human polymorphonuclear leukocytes (PMNs)


J Med Chem 42: 5289-310 (1999)

More data for this
Ligand-Target Pair
Leukotriene B4 receptor 2


(Homo sapiens)
BDBM50472429
PNG
(CHEMBL342297)
Show SMILES [Na+].OC(CCCCc1ccccc1)CC[C@H]1CCC[C@@H](CC([O-])=O)C1
Show InChI InChI=1S/C21H32O3.Na/c22-20(12-5-4-9-17-7-2-1-3-8-17)14-13-18-10-6-11-19(15-18)16-21(23)24;/h1-3,7-8,18-20,22H,4-6,9-16H2,(H,23,24);/q;+1/p-1/t18-,19-,20?;/m1./s1
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n/an/a 2.60E+3n/an/an/an/an/an/a



CNRS 5074

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]LTB4 (1 nM) to intact human polymorphonuclear leukocytes (PMNs)


J Med Chem 42: 5289-310 (1999)

More data for this
Ligand-Target Pair
Leukotriene 2


(Homo sapiens (Human))
BDBM50317624
PNG
(4-(2-(2-carboxyethyl)-3-(6-(4,6-diphenylpyridin-2-...)
Show SMILES OC(=O)CCCOc1cccc(CCCCCCOc2cc(cc(n2)-c2ccccc2)-c2ccccc2)c1CCC(O)=O
Show InChI InChI=1S/C36H39NO6/c38-35(39)20-12-24-42-33-19-11-18-28(31(33)21-22-36(40)41)15-5-1-2-10-23-43-34-26-30(27-13-6-3-7-14-27)25-32(37-34)29-16-8-4-9-17-29/h3-4,6-9,11,13-14,16-19,25-26H,1-2,5,10,12,15,20-24H2,(H,38,39)(H,40,41)
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n/an/a 3.06E+3n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
Antagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization prein...


J Med Chem 53: 3502-16 (2010)


Article DOI: 10.1021/jm1001919
BindingDB Entry DOI: 10.7270/Q2KW5G67
More data for this
Ligand-Target Pair
Leukotriene B4 receptor 2


(Homo sapiens)
BDBM50472426
PNG
(CHEMBL150746)
Show SMILES [Na+].CCCCCCCCC(O)\C=C\[C@H]1CCC[C@](O)(CC([O-])=O)C1
Show InChI InChI=1S/C19H34O4.Na/c1-2-3-4-5-6-7-10-17(20)12-11-16-9-8-13-19(23,14-16)15-18(21)22;/h11-12,16-17,20,23H,2-10,13-15H2,1H3,(H,21,22);/q;+1/p-1/b12-11+;/t16-,17?,19-;/m1./s1
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n/an/a 4.00E+3n/an/an/an/an/an/a



CNRS 5074

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]LTB4 (1 nM) to intact human polymorphonuclear leukocytes (PMNs)


J Med Chem 42: 5289-310 (1999)

More data for this
Ligand-Target Pair
Leukotriene B4 receptor 2


(Homo sapiens)
BDBM50472425
PNG
(CHEMBL149002)
Show SMILES CN(C)C(=O)C[C@]1(O)CCC[C@@H](C1)\C=C\C(C)(O)CCCCc1ccccc1
Show InChI InChI=1S/C24H37NO3/c1-23(27,15-8-7-12-20-10-5-4-6-11-20)17-14-21-13-9-16-24(28,18-21)19-22(26)25(2)3/h4-6,10-11,14,17,21,27-28H,7-9,12-13,15-16,18-19H2,1-3H3/b17-14+/t21-,23?,24+/m1/s1
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n/an/a 4.50E+3n/an/an/an/an/an/a



CNRS 5074

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]LTB4 (1 nM) to intact human polymorphonuclear leukocytes (PMNs)


J Med Chem 42: 5289-310 (1999)

More data for this
Ligand-Target Pair
Leukotriene B4 receptor 2


(Homo sapiens)
BDBM50476602
PNG
(CHEMBL242366)
Show SMILES CN(CCc1ccccc1)C(=O)Cc1ccc(OCCCCOc2ccc(CC(O)=O)cc2)cc1
Show InChI InChI=1S/C29H33NO5/c1-30(18-17-23-7-3-2-4-8-23)28(31)21-24-9-13-26(14-10-24)34-19-5-6-20-35-27-15-11-25(12-16-27)22-29(32)33/h2-4,7-16H,5-6,17-22H2,1H3,(H,32,33)
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n/an/a 4.70E+3n/an/an/an/an/an/a



Zentiva VUFB, a.s.

Curated by ChEMBL


Assay Description
Displacement of [3H]LTB4 from LTB4 receptor in guinea pig spleen membrane


Eur J Med Chem 42: 1084-94 (2007)

More data for this
Ligand-Target Pair
Leukotriene B4 receptor 2


(Homo sapiens)
BDBM50472440
PNG
(CHEMBL433542)
Show SMILES [Na+].OC(CCCCc1ccccc1)CC[C@H]1CCC[C@@](O)(CC([O-])=O)C1
Show InChI InChI=1S/C21H32O4.Na/c22-19(11-5-4-9-17-7-2-1-3-8-17)13-12-18-10-6-14-21(25,15-18)16-20(23)24;/h1-3,7-8,18-19,22,25H,4-6,9-16H2,(H,23,24);/q;+1/p-1/t18-,19?,21+;/m1./s1
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n/an/a 5.30E+3n/an/an/an/an/an/a



CNRS 5074

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]LTB4 (1 nM) to intact human polymorphonuclear leukocytes (PMNs)


J Med Chem 42: 5289-310 (1999)

More data for this
Ligand-Target Pair
Leukotriene B4 receptor 2


(Homo sapiens)
BDBM50472425
PNG
(CHEMBL149002)
Show SMILES CN(C)C(=O)C[C@]1(O)CCC[C@@H](C1)\C=C\C(C)(O)CCCCc1ccccc1
Show InChI InChI=1S/C24H37NO3/c1-23(27,15-8-7-12-20-10-5-4-6-11-20)17-14-21-13-9-16-24(28,18-21)19-22(26)25(2)3/h4-6,10-11,14,17,21,27-28H,7-9,12-13,15-16,18-19H2,1-3H3/b17-14+/t21-,23?,24+/m1/s1
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n/an/a 7.00E+3n/an/an/an/an/an/a



CNRS 5074

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]LTB4 (1 nM) to intact human polymorphonuclear leukocytes (PMNs)


J Med Chem 42: 5289-310 (1999)

More data for this
Ligand-Target Pair
Leukotriene B4 receptor 2


(Homo sapiens)
BDBM50472431
PNG
(CHEMBL264039)
Show SMILES CN(C)OC(=O)\C=C1\CCC[C@@H](C1)\C=C\C(O)CCCCc1ccccc1
Show InChI InChI=1S/C23H33NO3/c1-24(2)27-23(26)18-21-13-8-12-20(17-21)15-16-22(25)14-7-6-11-19-9-4-3-5-10-19/h3-5,9-10,15-16,18,20,22,25H,6-8,11-14,17H2,1-2H3/b16-15+,21-18-/t20-,22?/m1/s1
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n/an/a 7.00E+3n/an/an/an/an/an/a



CNRS 5074

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]LTB4 (1 nM) to intact human polymorphonuclear leukocytes (PMNs)


J Med Chem 42: 5289-310 (1999)

More data for this
Ligand-Target Pair
Leukotriene B4 receptor 2


(Homo sapiens)
BDBM50084103
PNG
(CHEMBL76530 | Sodium; [(1S,3S)-1-hydroxy-3-((E)-3-...)
Show SMILES CCCCCC(O)\C=C\[C@H]1CCC[C@@](O)(CC([O-])=O)C1
Show InChI InChI=1S/C16H28O4/c1-2-3-4-7-14(17)9-8-13-6-5-10-16(20,11-13)12-15(18)19/h8-9,13-14,17,20H,2-7,10-12H2,1H3,(H,18,19)/p-1/b9-8+/t13-,14?,16+/m1/s1
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n/an/a 8.00E+3n/an/an/an/an/an/a



CNRS 5074

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]LTB4 (1 nM) to intact human polymorphonuclear leukocytes (PMNs)


J Med Chem 42: 5289-310 (1999)

More data for this
Ligand-Target Pair
Leukotriene B4 receptor 2


(Homo sapiens)
BDBM50476606
PNG
(CHEMBL390458)
Show SMILES COc1cc(CC(O)=O)ccc1OCCCCOc1ccc(CC(=O)N(C)CCc2ccccc2)cc1
Show InChI InChI=1S/C30H35NO6/c1-31(17-16-23-8-4-3-5-9-23)29(32)21-24-10-13-26(14-11-24)36-18-6-7-19-37-27-15-12-25(22-30(33)34)20-28(27)35-2/h3-5,8-15,20H,6-7,16-19,21-22H2,1-2H3,(H,33,34)
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n/an/a 8.60E+3n/an/an/an/an/an/a



Zentiva VUFB, a.s.

Curated by ChEMBL


Assay Description
Displacement of [3H]LTB4 from LTB4 receptor in guinea pig spleen membrane


Eur J Med Chem 42: 1084-94 (2007)

More data for this
Ligand-Target Pair
Leukotriene B4 receptor 2


(Homo sapiens)
BDBM50472432
PNG
(CHEMBL358980)
Show SMILES [Na+].OC(CCCCc1ccccc1)\C=C\[C@H]1CCC[C@](O)(CC([O-])=O)C1
Show InChI InChI=1S/C21H30O4.Na/c22-19(11-5-4-9-17-7-2-1-3-8-17)13-12-18-10-6-14-21(25,15-18)16-20(23)24;/h1-3,7-8,12-13,18-19,22,25H,4-6,9-11,14-16H2,(H,23,24);/q;+1/p-1/b13-12+;/t18-,19?,21-;/m1./s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



CNRS 5074

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]LTB4 (1 nM) to intact human polymorphonuclear leukocytes (PMNs)


J Med Chem 42: 5289-310 (1999)

More data for this
Ligand-Target Pair
Leukotriene B4 receptor 2


(Homo sapiens)
BDBM50084103
PNG
(CHEMBL76530 | Sodium; [(1S,3S)-1-hydroxy-3-((E)-3-...)
Show SMILES CCCCCC(O)\C=C\[C@H]1CCC[C@@](O)(CC([O-])=O)C1
Show InChI InChI=1S/C16H28O4/c1-2-3-4-7-14(17)9-8-13-6-5-10-16(20,11-13)12-15(18)19/h8-9,13-14,17,20H,2-7,10-12H2,1H3,(H,18,19)/p-1/b9-8+/t13-,14?,16+/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



CNRS 5074

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]LTB4 (1 nM) to intact human polymorphonuclear leukocytes (PMNs)


J Med Chem 42: 5289-310 (1999)

More data for this
Ligand-Target Pair
Leukotriene B4 receptor 2


(Homo sapiens)
BDBM50472430
PNG
(CHEMBL150467)
Show SMILES [Na+].OC(=O)CC(O)(CCCCc1ccccc1)\C=C\[C@H]1CCC[C@@](O)(CC([O-])=O)C1
Show InChI InChI=1S/C23H32O6.Na/c24-20(25)16-22(28,12-5-4-9-18-7-2-1-3-8-18)14-11-19-10-6-13-23(29,15-19)17-21(26)27;/h1-3,7-8,11,14,19,28-29H,4-6,9-10,12-13,15-17H2,(H,24,25)(H,26,27);/q;+1/p-1/b14-11+;/t19-,22?,23+;/m1./s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



CNRS 5074

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]LTB4 (1 nM) to intact human polymorphonuclear leukocytes (PMNs)


J Med Chem 42: 5289-310 (1999)

More data for this
Ligand-Target Pair
Leukotriene B4 receptor 2


(Homo sapiens)
BDBM50472428
PNG
(CHEMBL345517)
Show SMILES [Na+].OC(CCCCc1ccccc1)\C=C\[C@H]1CCC\C(C1)=C\C([O-])=O
Show InChI InChI=1S/C21H28O3.Na/c22-20(12-5-4-9-17-7-2-1-3-8-17)14-13-18-10-6-11-19(15-18)16-21(23)24;/h1-3,7-8,13-14,16,18,20,22H,4-6,9-12,15H2,(H,23,24);/q;+1/p-1/b14-13+,19-16-;/t18-,20?;/m1./s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



CNRS 5074

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]LTB4 (1 nM) to intact human polymorphonuclear leukocytes (PMNs)


J Med Chem 42: 5289-310 (1999)

More data for this
Ligand-Target Pair
Leukotriene B4 receptor 2


(Homo sapiens)
BDBM50472427
PNG
(CHEMBL149001)
Show SMILES [Na+].CCCCCC(O)\C=C\[C@H]1CCC[C@](O)(CC([O-])=O)C1
Show InChI InChI=1S/C16H28O4.Na/c1-2-3-4-7-14(17)9-8-13-6-5-10-16(20,11-13)12-15(18)19;/h8-9,13-14,17,20H,2-7,10-12H2,1H3,(H,18,19);/q;+1/p-1/b9-8+;/t13-,14?,16-;/m1./s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



CNRS 5074

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]LTB4 (1 nM) to intact human polymorphonuclear leukocytes (PMNs)


J Med Chem 42: 5289-310 (1999)

More data for this
Ligand-Target Pair
Leukotriene B4 receptor 2


(Homo sapiens)
BDBM50472425
PNG
(CHEMBL149002)
Show SMILES CN(C)C(=O)C[C@]1(O)CCC[C@@H](C1)\C=C\C(C)(O)CCCCc1ccccc1
Show InChI InChI=1S/C24H37NO3/c1-23(27,15-8-7-12-20-10-5-4-6-11-20)17-14-21-13-9-16-24(28,18-21)19-22(26)25(2)3/h4-6,10-11,14,17,21,27-28H,7-9,12-13,15-16,18-19H2,1-3H3/b17-14+/t21-,23?,24+/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



CNRS 5074

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]LTB4 (1 nM) to intact human polymorphonuclear leukocytes (PMNs)


J Med Chem 42: 5289-310 (1999)

More data for this
Ligand-Target Pair
Leukotriene B4 receptor 2


(Homo sapiens)
BDBM50084106
PNG
(CHEMBL77513 | Sodium; [(1S,3S)-1-hydroxy-3-((E)-3-...)
Show SMILES OC(CCCCc1ccccc1)\C=C\[C@H]1CCC[C@@](O)(CC([O-])=O)C1
Show InChI InChI=1S/C21H30O4/c22-19(11-5-4-9-17-7-2-1-3-8-17)13-12-18-10-6-14-21(25,15-18)16-20(23)24/h1-3,7-8,12-13,18-19,22,25H,4-6,9-11,14-16H2,(H,23,24)/p-1/b13-12+/t18-,19?,21+/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



CNRS 5074

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]LTB4 (1 nM) to intact human polymorphonuclear leukocytes (PMNs)


J Med Chem 42: 5289-310 (1999)

More data for this
Ligand-Target Pair
Leukotriene B4 receptor 2


(Homo sapiens)
BDBM50472427
PNG
(CHEMBL149001)
Show SMILES [Na+].CCCCCC(O)\C=C\[C@H]1CCC[C@](O)(CC([O-])=O)C1
Show InChI InChI=1S/C16H28O4.Na/c1-2-3-4-7-14(17)9-8-13-6-5-10-16(20,11-13)12-15(18)19;/h8-9,13-14,17,20H,2-7,10-12H2,1H3,(H,18,19);/q;+1/p-1/b9-8+;/t13-,14?,16-;/m1./s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



CNRS 5074

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]LTB4 (1 nM) to intact human polymorphonuclear leukocytes (PMNs)


J Med Chem 42: 5289-310 (1999)

More data for this
Ligand-Target Pair
Leukotriene B4 receptor 2


(Homo sapiens)
BDBM50084101
PNG
(CHEMBL80541 | Sodium; [(1S,3S)-1-hydroxy-3-((E)-3-...)
Show SMILES CCCCCCCCC(O)\C=C\[C@H]1CCC[C@@](O)(CC([O-])=O)C1
Show InChI InChI=1S/C19H34O4/c1-2-3-4-5-6-7-10-17(20)12-11-16-9-8-13-19(23,14-16)15-18(21)22/h11-12,16-17,20,23H,2-10,13-15H2,1H3,(H,21,22)/p-1/b12-11+/t16-,17?,19+/m1/s1
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CNRS 5074

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]LTB4 (1 nM) to intact human polymorphonuclear leukocytes (PMNs)


J Med Chem 42: 5289-310 (1999)

More data for this
Ligand-Target Pair
Leukotriene B4 receptor 2


(Homo sapiens)
BDBM50472439
PNG
(CHEMBL357821)
Show SMILES CN(C)C(=O)\C=C1\CCC[C@@H](C1)\C=C\C(CCCCc1ccccc1)OC(C)=O
Show InChI InChI=1S/C25H35NO3/c1-20(27)29-24(15-8-7-12-21-10-5-4-6-11-21)17-16-22-13-9-14-23(18-22)19-25(28)26(2)3/h4-6,10-11,16-17,19,22,24H,7-9,12-15,18H2,1-3H3/b17-16+,23-19-/t22-,24?/m1/s1
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CNRS 5074

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]LTB4 (1 nM) to intact human polymorphonuclear leukocytes (PMNs)


J Med Chem 42: 5289-310 (1999)

More data for this
Ligand-Target Pair
Leukotriene B4 receptor 2


(Homo sapiens)
BDBM50472438
PNG
(CHEMBL148868)
Show SMILES [Na+].O[C@@]1(CC([O-])=O)CCC[C@@H](C1)\C=C\C(=O)CCCCc1ccccc1
Show InChI InChI=1S/C21H28O4.Na/c22-19(11-5-4-9-17-7-2-1-3-8-17)13-12-18-10-6-14-21(25,15-18)16-20(23)24;/h1-3,7-8,12-13,18,25H,4-6,9-11,14-16H2,(H,23,24);/q;+1/p-1/b13-12+;/t18-,21+;/m1./s1
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CNRS 5074

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]LTB4 (1 nM) to intact human polymorphonuclear leukocytes (PMNs)


J Med Chem 42: 5289-310 (1999)

More data for this
Ligand-Target Pair
Leukotriene B4 receptor 2


(Homo sapiens)
BDBM50472437
PNG
(CHEMBL344518)
Show SMILES CN(C)OC(=O)C[C@]1(O)CCC[C@@H](C1)\C=C\C(O)CCCCc1ccccc1
Show InChI InChI=1S/C23H35NO4/c1-24(2)28-22(26)18-23(27)16-8-12-20(17-23)14-15-21(25)13-7-6-11-19-9-4-3-5-10-19/h3-5,9-10,14-15,20-21,25,27H,6-8,11-13,16-18H2,1-2H3/b15-14+/t20-,21?,23+/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



CNRS 5074

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]LTB4 (1 nM) to intact human polymorphonuclear leukocytes (PMNs)


J Med Chem 42: 5289-310 (1999)

More data for this
Ligand-Target Pair
Leukotriene B4 receptor 2


(Homo sapiens)
BDBM50472428
PNG
(CHEMBL345517)
Show SMILES [Na+].OC(CCCCc1ccccc1)\C=C\[C@H]1CCC\C(C1)=C\C([O-])=O
Show InChI InChI=1S/C21H28O3.Na/c22-20(12-5-4-9-17-7-2-1-3-8-17)14-13-18-10-6-11-19(15-18)16-21(23)24;/h1-3,7-8,13-14,16,18,20,22H,4-6,9-12,15H2,(H,23,24);/q;+1/p-1/b14-13+,19-16-;/t18-,20?;/m1./s1
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CNRS 5074

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]LTB4 (1 nM) to intact human polymorphonuclear leukocytes (PMNs)


J Med Chem 42: 5289-310 (1999)

More data for this
Ligand-Target Pair
Leukotriene B4 receptor 2


(Homo sapiens)
BDBM50472435
PNG
(CHEMBL2112036)
Show SMILES CN(C)C(=O)C[C@]1(O)CCC[C@@H](C1)\C=C\[C@H](O)CCCCc1ccccc1
Show InChI InChI=1S/C23H35NO3/c1-24(2)22(26)18-23(27)16-8-12-20(17-23)14-15-21(25)13-7-6-11-19-9-4-3-5-10-19/h3-5,9-10,14-15,20-21,25,27H,6-8,11-13,16-18H2,1-2H3/b15-14+/t20-,21-,23+/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



CNRS 5074

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]LTB4 (1 nM) to intact human polymorphonuclear leukocytes (PMNs)


J Med Chem 42: 5289-310 (1999)

More data for this
Ligand-Target Pair
Leukotriene B4 receptor 2


(Homo sapiens)
BDBM50472436
PNG
(CHEMBL2112037)
Show SMILES [Na+].O[C@@H](CCCCc1ccccc1)\C=C\[C@H]1CCC[C@](O)(C1)C([O-])=O
Show InChI InChI=1S/C20H28O4.Na/c21-18(11-5-4-9-16-7-2-1-3-8-16)13-12-17-10-6-14-20(24,15-17)19(22)23;/h1-3,7-8,12-13,17-18,21,24H,4-6,9-11,14-15H2,(H,22,23);/q;+1/p-1/b13-12+;/t17-,18+,20+;/m1./s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



CNRS 5074

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]LTB4 (1 nM) to intact human polymorphonuclear leukocytes (PMNs)


J Med Chem 42: 5289-310 (1999)

More data for this
Ligand-Target Pair
Leukotriene B4 receptor 2


(Homo sapiens)
BDBM50476605
PNG
(CHEMBL242365)
Show SMILES CN(CCc1ccccc1)C(=O)Cc1ccc(OCCCOc2ccc(CC(O)=O)cc2)cc1
Show InChI InChI=1S/C28H31NO5/c1-29(17-16-22-6-3-2-4-7-22)27(30)20-23-8-12-25(13-9-23)33-18-5-19-34-26-14-10-24(11-15-26)21-28(31)32/h2-4,6-15H,5,16-21H2,1H3,(H,31,32)
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n/an/a 1.80E+4n/an/an/an/an/an/a



Zentiva VUFB, a.s.

Curated by ChEMBL


Assay Description
Displacement of [3H]LTB4 from LTB4 receptor in guinea pig spleen membrane


Eur J Med Chem 42: 1084-94 (2007)

More data for this
Ligand-Target Pair
Leukotriene B4 receptor 2


(Homo sapiens)
BDBM50476601
PNG
(CHEMBL242367)
Show SMILES COc1cc(CC(O)=O)ccc1OCCCOc1ccc(CC(=O)N(C)CCc2ccccc2)cc1
Show InChI InChI=1S/C29H33NO6/c1-30(16-15-22-7-4-3-5-8-22)28(31)20-23-9-12-25(13-10-23)35-17-6-18-36-26-14-11-24(21-29(32)33)19-27(26)34-2/h3-5,7-14,19H,6,15-18,20-21H2,1-2H3,(H,32,33)
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n/an/a 6.70E+4n/an/an/an/an/an/a



Zentiva VUFB, a.s.

Curated by ChEMBL


Assay Description
Displacement of [3H]LTB4 from LTB4 receptor in guinea pig spleen membrane


Eur J Med Chem 42: 1084-94 (2007)

More data for this
Ligand-Target Pair
Leukotriene B4 receptor 2


(Homo sapiens)
BDBM50000541
PNG
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Show SMILES CC(N(O)C(N)=O)c1cc2ccccc2s1
Show InChI InChI=1/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Zentiva VUFB, a.s.

Curated by ChEMBL


Assay Description
Displacement of [3H]LTB4 from LTB4 receptor in guinea pig spleen membrane


Eur J Med Chem 42: 1084-94 (2007)

More data for this
Ligand-Target Pair
Leukotriene 2


(Homo sapiens (Human))
BDBM50013889
PNG
((5S,6Z,8E,10E,12R,14Z)-5,12-dihydroxyicosa-6,8,10,...)
Show SMILES CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O
Show InChI InChI=1/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t18-,19-/s2
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2n/an/an/an/an/an/an/an/a



Ciba-Geigy Corporation

Curated by PDSP Ki Database




J Pharmacol Exp Ther 262: 80-9 (1992)


BindingDB Entry DOI: 10.7270/Q21C1VBX
More data for this
Ligand-Target Pair
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