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Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Large neutral amino acids transporter small subunit 1'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Large neutral amino acids transporter small subunit 1


(Homo sapiens)
BDBM50174344
PNG
(CHEMBL58129)
Show SMILES N[C@@H](Cc1cccc(c1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C15H15NO2/c16-14(15(17)18)10-11-5-4-8-13(9-11)12-6-2-1-3-7-12/h1-9,14H,10,16H2,(H,17,18)/t14-/m0/s1
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 6.60E+3n/an/an/an/an/an/a



University of Nebraska Kearney

Curated by ChEMBL


Assay Description
Inhibition of human LAT1 expressed in HEK cells assessed as reduction in uptake of [3H]-gabapentin after 3 mins by scintillation counting based cis-i...


Bioorg Med Chem Lett 26: 2616-2621 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.023
BindingDB Entry DOI: 10.7270/Q2ZS2ZFD
More data for this
Ligand-Target Pair
Large neutral amino acids transporter small subunit 1


(Homo sapiens)
BDBM50174345
PNG
(CHEMBL3809112)
Show SMILES N[C@@H](Cc1cccc(Cc2ccccc2)c1)C(O)=O
Show InChI InChI=1S/C16H17NO2/c17-15(16(18)19)11-14-8-4-7-13(10-14)9-12-5-2-1-3-6-12/h1-8,10,15H,9,11,17H2,(H,18,19)/t15-/m0/s1
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 7.30E+3n/an/an/an/an/an/a



University of Nebraska Kearney

Curated by ChEMBL


Assay Description
Inhibition of human LAT1 expressed in HEK cells assessed as reduction in uptake of [3H]-gabapentin after 3 mins by scintillation counting based cis-i...


Bioorg Med Chem Lett 26: 2616-2621 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.023
BindingDB Entry DOI: 10.7270/Q2ZS2ZFD
More data for this
Ligand-Target Pair
Large neutral amino acids transporter small subunit 1


(Homo sapiens)
BDBM50174343
PNG
(CHEMBL3809645)
Show SMILES N[C@@H](Cc1ccc(O)c(Cc2ccccc2)c1)C(O)=O
Show InChI InChI=1S/C16H17NO3/c17-14(16(19)20)10-12-6-7-15(18)13(9-12)8-11-4-2-1-3-5-11/h1-7,9,14,18H,8,10,17H2,(H,19,20)/t14-/m0/s1
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 9.10E+3n/an/an/an/an/an/a



University of Nebraska Kearney

Curated by ChEMBL


Assay Description
Inhibition of human LAT1 expressed in HEK cells assessed as reduction in uptake of [3H]-gabapentin after 3 mins by scintillation counting based cis-i...


Bioorg Med Chem Lett 26: 2616-2621 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.023
BindingDB Entry DOI: 10.7270/Q2ZS2ZFD
More data for this
Ligand-Target Pair