BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 30 hits Enz. Inhib. hit(s) with Target = 'Lck'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lck


(Homo sapiens (human))
BDBM14948
PNG
(4-Methyl-3-(3-(2-(methylamino)pyrimidin-4-yl)pyrid...)
Show SMILES CNc1nccc(n1)-c1cccnc1Oc1cc(ccc1C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H20F3N5O2/c1-15-8-9-16(22(34)32-18-6-3-5-17(14-18)25(26,27)28)13-21(15)35-23-19(7-4-11-30-23)20-10-12-31-24(29-2)33-20/h3-14H,1-2H3,(H,32,34)(H,29,31,33)
PDB
MMDB

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a<1n/an/an/an/a7.522



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Citation and Details
More data for this
Ligand-Target Pair
Lck


(Homo sapiens (human))
BDBM14949
PNG
(2-aminoquinazoline 5 | 3-(2-aminoquinazolin-6-yl)-...)
Show SMILES Cc1ccc(cc1-c1ccc2nc(N)ncc2c1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H17F3N4O/c1-13-5-6-15(21(31)29-18-4-2-3-17(11-18)23(24,25)26)10-19(13)14-7-8-20-16(9-14)12-28-22(27)30-20/h2-12H,1H3,(H,29,31)(H2,27,28,30)
PDB
MMDB

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
DrugBank
MMDB
PDB
Article
PubMed
n/an/a<1n/an/an/an/a7.522



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Lck


(Homo sapiens (human))
BDBM14950
PNG
(3-(2-(2-Aminopyrimidin-5-yl)ethynyl)-4-methyl-N-(3...)
Show SMILES Cc1ccc(cc1C#Cc1cnc(N)nc1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C21H15F3N4O/c1-13-5-7-16(9-15(13)8-6-14-11-26-20(25)27-12-14)19(29)28-18-4-2-3-17(10-18)21(22,23)24/h2-5,7,9-12H,1H3,(H,28,29)(H2,25,26,27)
PDB
MMDB

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 1n/an/an/an/a7.522



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Citation and Details
More data for this
Ligand-Target Pair
Lck


(Homo sapiens (human))
BDBM14969
PNG
(4-Methyl-3-(2-(quinolin-3-yl)ethynyl)-N-(3-(triflu...)
Show SMILES Cc1ccc(cc1C#Cc1cnc2ccccc2c1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C26H17F3N2O/c1-17-9-11-21(25(32)31-23-7-4-6-22(15-23)26(27,28)29)14-19(17)12-10-18-13-20-5-2-3-8-24(20)30-16-18/h2-9,11,13-16H,1H3,(H,31,32)
PDB
MMDB

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 1n/an/an/an/a7.522



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Citation and Details
More data for this
Ligand-Target Pair
Lck


(Homo sapiens (human))
BDBM14966
PNG
(3-(2-(6-Aminopyridin-3-yl)ethynyl)-4-methyl-N-(3-(...)
Show SMILES Cc1ccc(cc1C#Cc1ccc(N)nc1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C22H16F3N3O/c1-14-5-8-17(11-16(14)9-6-15-7-10-20(26)27-13-15)21(29)28-19-4-2-3-18(12-19)22(23,24)25/h2-5,7-8,10-13H,1H3,(H2,26,27)(H,28,29)
PDB
MMDB

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 1n/an/an/an/a7.522



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Citation and Details
More data for this
Ligand-Target Pair
Lck


(Homo sapiens (human))
BDBM14967
PNG
(3-(2-(3H-Imidazo[4,5-b]pyridin-6-yl)ethynyl)-4-met...)
Show SMILES Cc1ccc(cc1C#Cc1cnc2nc[nH]c2c1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H15F3N4O/c1-14-5-7-17(22(31)30-19-4-2-3-18(11-19)23(24,25)26)10-16(14)8-6-15-9-20-21(27-12-15)29-13-28-20/h2-5,7,9-13H,1H3,(H,30,31)(H,27,28,29)
PDB
MMDB

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a<1n/an/an/an/a7.522



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Citation and Details
More data for this
Ligand-Target Pair
Lck


(Homo sapiens (human))
BDBM14970
PNG
(4-Methyl-3-(2-(quinoxalin-2-yl)ethynyl)-N-(3-(trif...)
Show SMILES Cc1ccc(cc1C#Cc1cnc2ccccc2n1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H16F3N3O/c1-16-9-10-18(24(32)31-20-6-4-5-19(14-20)25(26,27)28)13-17(16)11-12-21-15-29-22-7-2-3-8-23(22)30-21/h2-10,13-15H,1H3,(H,31,32)
PDB
MMDB

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

AffyNet 
Article
PubMed
n/an/a 4n/an/an/an/a7.522



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Citation and Details
More data for this
Ligand-Target Pair
Lck


(Homo sapiens (human))
BDBM14951
PNG
(3-(2-(2-Aminopyrimidin-5-yl)ethynyl)-N-(3-(trifluo...)
Show SMILES Nc1ncc(cn1)C#Cc1cccc(c1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C20H13F3N4O/c21-20(22,23)16-5-2-6-17(10-16)27-18(28)15-4-1-3-13(9-15)7-8-14-11-25-19(24)26-12-14/h1-6,9-12H,(H,27,28)(H2,24,25,26)
PDB
MMDB

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 19n/an/an/an/a7.522



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Citation and Details
More data for this
Ligand-Target Pair
Lck


(Homo sapiens (human))
BDBM14957
PNG
(5-(2-(2-Aminopyrimidin-5-yl)ethynyl)-N-(2-((3-(dim...)
Show SMILES CN(C)CCCN(C)c1ccc(cc1NC(=O)c1cc(ccc1F)C#Cc1cnc(N)nc1)C(F)(F)F
Show InChI InChI=1S/C26H26F4N6O/c1-35(2)11-4-12-36(3)23-10-8-19(26(28,29)30)14-22(23)34-24(37)20-13-17(7-9-21(20)27)5-6-18-15-32-25(31)33-16-18/h7-10,13-16H,4,11-12H2,1-3H3,(H,34,37)(H2,31,32,33)
PDB
MMDB

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 21n/an/an/an/a7.522



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Citation and Details
More data for this
Ligand-Target Pair
Lck


(Homo sapiens (human))
BDBM14953
PNG
(3-(2-(2-Aminopyrimidin-5-yl)ethynyl)-4-methyl-N-(2...)
Show SMILES Cc1ccc(cc1C#Cc1cnc(N)nc1)C(=O)Nc1cc(ccc1N1CCCCC1)C(F)(F)F
Show InChI InChI=1S/C26H24F3N5O/c1-17-5-7-20(13-19(17)8-6-18-15-31-25(30)32-16-18)24(35)33-22-14-21(26(27,28)29)9-10-23(22)34-11-3-2-4-12-34/h5,7,9-10,13-16H,2-4,11-12H2,1H3,(H,33,35)(H2,30,31,32)
PDB
MMDB

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 42n/an/an/an/a7.522



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Citation and Details
More data for this
Ligand-Target Pair
Lck


(Homo sapiens (human))
BDBM14952
PNG
(5-(2-(2-Aminopyrimidin-5-yl)ethynyl)-2-fluoro-N-(3...)
Show SMILES Nc1ncc(cn1)C#Cc1ccc(F)c(c1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C20H12F4N4O/c21-17-7-6-12(4-5-13-10-26-19(25)27-11-13)8-16(17)18(29)28-15-3-1-2-14(9-15)20(22,23)24/h1-3,6-11H,(H,28,29)(H2,25,26,27)
PDB
MMDB

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 65n/an/an/an/a7.522



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Citation and Details
More data for this
Ligand-Target Pair
Lck


(Homo sapiens (human))
BDBM14961
PNG
((S)-5-(2-(2-Aminopyrimidin-5-yl)ethynyl)-N-(2-(3-(...)
Show SMILES CN(C)[C@H]1CCCN(C1)c1ccc(cc1NC(=O)c1cc(ccc1F)C#Cc1cnc(N)nc1)C(F)(F)F
Show InChI InChI=1S/C27H26F4N6O/c1-36(2)20-4-3-11-37(16-20)24-10-8-19(27(29,30)31)13-23(24)35-25(38)21-12-17(7-9-22(21)28)5-6-18-14-33-26(32)34-15-18/h7-10,12-15,20H,3-4,11,16H2,1-2H3,(H,35,38)(H2,32,33,34)/t20-/m0/s1
PDB
MMDB

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 130n/an/an/an/a7.522



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Citation and Details
More data for this
Ligand-Target Pair
Lck


(Homo sapiens (human))
BDBM14959
PNG
(5-(2-(2-Aminopyrimidin-5-yl)ethynyl)-N-(2-(4-(dime...)
Show SMILES CN(C)C1CCN(CC1)c1ccc(cc1NC(=O)c1cc(ccc1F)C#Cc1cnc(N)nc1)C(F)(F)F
Show InChI InChI=1S/C27H26F4N6O/c1-36(2)20-9-11-37(12-10-20)24-8-6-19(27(29,30)31)14-23(24)35-25(38)21-13-17(5-7-22(21)28)3-4-18-15-33-26(32)34-16-18/h5-8,13-16,20H,9-12H2,1-2H3,(H,35,38)(H2,32,33,34)
PDB
MMDB

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 150n/an/an/an/a7.522



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Citation and Details
More data for this
Ligand-Target Pair
Lck


(Homo sapiens (human))
BDBM14968
PNG
(N-Methyl-5-(2-(2-methyl-5-((3-(trifluoromethyl)phe...)
Show SMILES CNC(=O)c1ccc(cn1)C#Cc1cc(ccc1C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H18F3N3O2/c1-15-6-9-18(22(31)30-20-5-3-4-19(13-20)24(25,26)27)12-17(15)10-7-16-8-11-21(29-14-16)23(32)28-2/h3-6,8-9,11-14H,1-2H3,(H,28,32)(H,30,31)
PDB
MMDB

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 154n/an/an/an/a7.522



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Citation and Details
More data for this
Ligand-Target Pair
Lck


(Homo sapiens (human))
BDBM14958
PNG
(5-[(2-aminopyrimidin-5-yl)ethynyl]-2-fluoro-N-[2-(...)
Show SMILES CN1CCN(CC1)c1ccc(cc1NC(=O)c1cc(ccc1F)C#Cc1cnc(N)nc1)C(F)(F)F
Show InChI InChI=1S/C25H22F4N6O/c1-34-8-10-35(11-9-34)22-7-5-18(25(27,28)29)13-21(22)33-23(36)19-12-16(4-6-20(19)26)2-3-17-14-31-24(30)32-15-17/h4-7,12-15H,8-11H2,1H3,(H,33,36)(H2,30,31,32)
PDB
MMDB

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 210n/an/an/an/a7.522



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Citation and Details
More data for this
Ligand-Target Pair
Lck


(Homo sapiens (human))
BDBM14955
PNG
(5-(2-(2-Aminopyrimidin-5-yl)ethynyl)-2-fluoro-N-(2...)
Show SMILES Nc1ncc(cn1)C#Cc1ccc(F)c(c1)C(=O)Nc1cc(ccc1N1CCCCC1)C(F)(F)F
Show InChI InChI=1S/C25H21F4N5O/c26-20-8-6-16(4-5-17-14-31-24(30)32-15-17)12-19(20)23(35)33-21-13-18(25(27,28)29)7-9-22(21)34-10-2-1-3-11-34/h6-9,12-15H,1-3,10-11H2,(H,33,35)(H2,30,31,32)
PDB
MMDB

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 370n/an/an/an/a7.522



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Citation and Details
More data for this
Ligand-Target Pair
Lck


(Homo sapiens (human))
BDBM14954
PNG
(3-(2-(2-Aminopyrimidin-5-yl)ethynyl)-N-(2-(piperid...)
Show SMILES Nc1ncc(cn1)C#Cc1cccc(c1)C(=O)Nc1cc(ccc1N1CCCCC1)C(F)(F)F
Show InChI InChI=1S/C25H22F3N5O/c26-25(27,28)20-9-10-22(33-11-2-1-3-12-33)21(14-20)32-23(34)19-6-4-5-17(13-19)7-8-18-15-30-24(29)31-16-18/h4-6,9-10,13-16H,1-3,11-12H2,(H,32,34)(H2,29,30,31)
PDB
MMDB

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 410n/an/an/an/a7.522



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Citation and Details
More data for this
Ligand-Target Pair
Lck


(Homo sapiens (human))
BDBM14962
PNG
((S)-5-(2-(2-Aminopyrimidin-5-yl)ethynyl)-2-fluoro-...)
Show SMILES CN[C@H]1CCCN(C1)c1ccc(cc1NC(=O)c1cc(ccc1F)C#Cc1cnc(N)nc1)C(F)(F)F
Show InChI InChI=1S/C26H24F4N6O/c1-32-19-3-2-10-36(15-19)23-9-7-18(26(28,29)30)12-22(23)35-24(37)20-11-16(6-8-21(20)27)4-5-17-13-33-25(31)34-14-17/h6-9,11-14,19,32H,2-3,10,15H2,1H3,(H,35,37)(H2,31,33,34)/t19-/m0/s1
PDB
MMDB

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 620n/an/an/an/a7.522



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Citation and Details
More data for this
Ligand-Target Pair
Lck


(Homo sapiens (human))
BDBM14960
PNG
((R)-5-(2-(2-Aminopyrimidin-5-yl)ethynyl)-N-(2-(3-(...)
Show SMILES CN(C)[C@@H]1CCCN(C1)c1ccc(cc1NC(=O)c1cc(ccc1F)C#Cc1cnc(N)nc1)C(F)(F)F
Show InChI InChI=1S/C27H26F4N6O/c1-36(2)20-4-3-11-37(16-20)24-10-8-19(27(29,30)31)13-23(24)35-25(38)21-12-17(7-9-22(21)28)5-6-18-14-33-26(32)34-15-18/h7-10,12-15,20H,3-4,11,16H2,1-2H3,(H,35,38)(H2,32,33,34)/t20-/m1/s1
PDB
MMDB

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 780n/an/an/an/a7.522



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Citation and Details
More data for this
Ligand-Target Pair
Lck


(Homo sapiens (human))
BDBM14965
PNG
((S)-5-(2-(2-Aminopyrimidin-5-yl)ethynyl)-N-(2-(3-(...)
Show SMILES CN(C)[C@H]1CCN(C1)c1ccc(cc1NC(=O)c1cc(ccc1F)C#Cc1cnc(N)nc1)C(F)(F)F
Show InChI InChI=1S/C26H24F4N6O/c1-35(2)19-9-10-36(15-19)23-8-6-18(26(28,29)30)12-22(23)34-24(37)20-11-16(5-7-21(20)27)3-4-17-13-32-25(31)33-14-17/h5-8,11-14,19H,9-10,15H2,1-2H3,(H,34,37)(H2,31,32,33)/t19-/m0/s1
PDB
MMDB

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 1.10E+3n/an/an/an/a7.522



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Citation and Details
More data for this
Ligand-Target Pair
Lck


(Homo sapiens (human))
BDBM14963
PNG
((S)-N-(2-(3-Aminopiperidin-1-yl)-5-(trifluoromethy...)
Show SMILES N[C@H]1CCCN(C1)c1ccc(cc1NC(=O)c1cc(ccc1F)C#Cc1cnc(N)nc1)C(F)(F)F
Show InChI InChI=1S/C25H22F4N6O/c26-20-7-5-15(3-4-16-12-32-24(31)33-13-16)10-19(20)23(36)34-21-11-17(25(27,28)29)6-8-22(21)35-9-1-2-18(30)14-35/h5-8,10-13,18H,1-2,9,14,30H2,(H,34,36)(H2,31,32,33)/t18-/m0/s1
PDB
MMDB

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 1.48E+3n/an/an/an/a7.522



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Citation and Details
More data for this
Ligand-Target Pair
Lck


(Homo sapiens (human))
BDBM14964
PNG
((R)-5-(2-(2-Aminopyrimidin-5-yl)ethynyl)-N-(2-(3-(...)
Show SMILES CN(C)[C@@H]1CCN(C1)c1ccc(cc1NC(=O)c1cc(ccc1F)C#Cc1cnc(N)nc1)C(F)(F)F
Show InChI InChI=1S/C26H24F4N6O/c1-35(2)19-9-10-36(15-19)23-8-6-18(26(28,29)30)12-22(23)34-24(37)20-11-16(5-7-21(20)27)3-4-17-13-32-25(31)33-14-17/h5-8,11-14,19H,9-10,15H2,1-2H3,(H,34,37)(H2,31,32,33)/t19-/m1/s1
PDB
MMDB

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 1.92E+3n/an/an/an/a7.522



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Citation and Details
More data for this
Ligand-Target Pair
Lck


(Homo sapiens (human))
BDBM14956
PNG
(5-(2-(2-Aminopyrimidin-5-yl)ethynyl)-2-methoxy-N-(...)
Show SMILES COc1ccc(cc1C(=O)Nc1cc(ccc1N1CCCCC1)C(F)(F)F)C#Cc1cnc(N)nc1
Show InChI InChI=1S/C26H24F3N5O2/c1-36-23-10-7-17(5-6-18-15-31-25(30)32-16-18)13-20(23)24(35)33-21-14-19(26(27,28)29)8-9-22(21)34-11-3-2-4-12-34/h7-10,13-16H,2-4,11-12H2,1H3,(H,33,35)(H2,30,31,32)
PDB
MMDB

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a>2.50E+4n/an/an/an/a7.522



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Citation and Details
More data for this
Ligand-Target Pair
LCK


(HUMAN)
BDBM25116
PNG
(1-tert-butyl-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]...)
Show SMILES Cc1ccc(cc1)-c1nn(c2ncnc(N)c12)C(C)(C)C
Show InChI InChI=1S/C16H19N5/c1-10-5-7-11(8-6-10)13-12-14(17)18-9-19-15(12)21(20-13)16(2,3)4/h5-9H,1-4H3,(H2,17,18,19)
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
Article
PubMed
50n/an/an/an/an/an/an/an/a



University of Dundee

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
LCK


(HUMAN)
BDBM50142887
PNG
(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
Show SMILES CC(C)(C)n1nc(-c2ccc(Cl)cc2)c2c(N)ncnc12
Show InChI InChI=1S/C15H16ClN5/c1-15(2,3)21-14-11(13(17)18-8-19-14)12(20-21)9-4-6-10(16)7-5-9/h4-8H,1-3H3,(H2,17,18,19)
GoogleScholar
AffyNet 
Purchase

CHEMBL
MMDB
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
60n/an/an/an/an/an/an/an/a



University of Dundee

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
LCK


(HUMAN)
BDBM7393
PNG
(3-[(2Z,3E)-3-(hydroxyimino)-2,3-dihydro-1H-indol-2...)
Show SMILES O=Nc1c([nH]c2ccccc12)C1C(=O)Nc2ccccc12
Show InChI InChI=1S/C16H11N3O2/c20-16-13(9-5-1-3-7-11(9)18-16)15-14(19-21)10-6-2-4-8-12(10)17-15/h1-8,13,17H,(H,18,20)
GoogleScholar
AffyNet 
CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
Article
PubMed
300n/an/an/an/an/an/an/an/a



University of Dundee

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
LCK


(HUMAN)
BDBM7262
PNG
(14-nitro-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...)
Show SMILES [O-][N+](=O)c1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1
Show InChI InChI=1S/C16H11N3O3/c20-15-8-12-11-7-9(19(21)22)5-6-14(11)18-16(12)10-3-1-2-4-13(10)17-15/h1-7,18H,8H2,(H,17,20)
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
Article
PubMed
470n/an/an/an/an/an/an/an/a



University of Dundee

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
LCK


(HUMAN)
BDBM7266
PNG
(14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...)
Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1
Show InChI InChI=1S/C16H11BrN2O/c17-9-5-6-14-11(7-9)12-8-15(20)18-13-4-2-1-3-10(13)16(12)19-14/h1-7,19H,8H2,(H,18,20)
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
470n/an/an/an/an/an/an/an/a



University of Dundee

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
LCK


(HUMAN)
BDBM50237710
PNG
(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)
Show SMILES Cc1cn(cn1)-c1cc(NC(=O)c2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C28H22F3N7O/c1-17-5-6-19(10-25(17)37-27-33-9-7-24(36-27)20-4-3-8-32-14-20)26(39)35-22-11-21(28(29,30)31)12-23(13-22)38-15-18(2)34-16-38/h3-16H,1-2H3,(H,35,39)(H,33,36,37)
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
Article
PubMed
2.14E+3n/an/an/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
LCK


(HUMAN)
BDBM13530
PNG
(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Show SMILES CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1
Show InChI InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34)
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
Article
PubMed
6.89E+3n/an/an/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair