BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'Lecithin-cholesterol acyltransferase (LCAT)'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lecithin-cholesterol acyltransferase (LCAT)


(Homo sapiens (Human))
BDBM92615
PNG
(Difluoroketone phospholipid analogue, 3)
Show SMILES CCCCCCCCCCCCCCCCC(=O)C(F)(F)C(COCCCCCCCC)COP([O-])(=O)OCC[N+](C)(C)C
Show InChI InChI=1S/C34H68F2NO6P/c1-6-8-10-12-14-15-16-17-18-19-20-21-22-24-26-33(38)34(35,36)32(30-41-28-25-23-13-11-9-7-2)31-43-44(39,40)42-29-27-37(3,4)5/h32H,6-31H2,1-5H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
n/an/a 28n/an/an/an/a7.54


TBA

Assay Description
The phospholipase A2 activity of LCAT was assayed using lecithin and apoA-I containing [9,10-3H] dipalmitoylphosphatidylcholine (DPPC) and measuremen...


Citation and Details
More data for this
Ligand-Target Pair
Lecithin-cholesterol acyltransferase (LCAT)


(Homo sapiens (Human))
BDBM92614
PNG
(Difluoroketone phospholipid analogue, 2)
Show SMILES CCCCCCCCOCC(COP([O-])(=O)OCC[N+](C)(C)C)C(F)(F)C(=O)CCCCCCC
Show InChI InChI=1S/C25H50F2NO6P/c1-6-8-10-12-14-16-19-32-21-23(22-34-35(30,31)33-20-18-28(3,4)5)25(26,27)24(29)17-15-13-11-9-7-2/h23H,6-22H2,1-5H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
n/an/a 60n/an/an/an/a7.54


TBA

Assay Description
The phospholipase A2 activity of LCAT was assayed using lecithin and apoA-I containing [9,10-3H] dipalmitoylphosphatidylcholine (DPPC) and measuremen...


Citation and Details
More data for this
Ligand-Target Pair
Lecithin-cholesterol acyltransferase (LCAT)


(Homo sapiens (Human))
BDBM92616
PNG
(Difluoroketone phospholipid analogue, 4)
Show SMILES CCCCCCCC(=O)OCC(COP([O-])(=O)OCC[N+](C)(C)C)CC(=O)C(F)(F)CCCCCC
Show InChI InChI=1S/C25H48F2NO7P/c1-6-8-10-12-13-15-24(30)33-20-22(19-23(29)25(26,27)16-14-11-9-7-2)21-35-36(31,32)34-18-17-28(3,4)5/h22H,6-21H2,1-5H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
n/an/a 60n/an/an/an/a7.54


TBA

Assay Description
The phospholipase A2 activity of LCAT was assayed using lecithin and apoA-I containing [9,10-3H] dipalmitoylphosphatidylcholine (DPPC) and measuremen...


Citation and Details
More data for this
Ligand-Target Pair
Lecithin-cholesterol acyltransferase (LCAT)


(Homo sapiens (Human))
BDBM92613
PNG
(Difluoroketone phospholipid analogue, 1)
Show SMILES CCCCCCCC(=O)C(F)(F)CCOP([O-])(=O)OCC[N+](C)(C)C
Show InChI InChI=1S/C16H32F2NO5P/c1-5-6-7-8-9-10-15(20)16(17,18)11-13-23-25(21,22)24-14-12-19(2,3)4/h5-14H2,1-4H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
n/an/a>500n/an/an/an/a7.54


TBA

Assay Description
The phospholipase A2 activity of LCAT was assayed using lecithin and apoA-I containing [9,10-3H] dipalmitoylphosphatidylcholine (DPPC) and measuremen...


Citation and Details
More data for this
Ligand-Target Pair