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Found 2100 hits Enz. Inhib. hit(s) with Target = 'Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM239190
PNG
(US9416126, A15)
Show SMILES CC(C)N1CCN(CC1)c1cc(ncn1)-c1n[nH]c2ccc(cc12)-c1cnn(C)c1
GoogleScholar
AffyNet 
PC sid
UniChem
AffyNet 
US Patent
n/an/a 0.730n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound(98 μM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well b...


US Patent US9416126 (2016)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM239542
PNG
(US9416126, U26)
Show SMILES COc1ccncc1-c1ccc2[nH]nc(-c3cc(ncn3)N3C[C@H](C)O[C@H](C)C3)c2c1
GoogleScholar
AffyNet 
PC sid
UniChem
AffyNet 
US Patent
n/an/a 0.75n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound(98 μM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well b...


US Patent US9416126 (2016)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM239082
PNG
(US9416126, A8)
Show SMILES CCN1CCN(CC1)c1cc(ncn1)-c1n[nH]c2ccc(cc12)-c1cnn(C)c1
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/a 0.760n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound(98 μM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well b...


US Patent US9416126 (2016)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM239540
PNG
(US9416126, U24)
Show SMILES CC(C)N1CCN(CC1)c1cc(ncn1)-c1n[nH]c2ccc(cc12)-c1cn[nH]c1
GoogleScholar
AffyNet 
PC sid
UniChem
AffyNet 
US Patent
n/an/a 0.960n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound(98 μM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well b...


US Patent US9416126 (2016)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM50059889
PNG
((staurosporine)3-methoxy-2-methyl-4-methylamino-(2...)
Show SMILES CN[C@@H]1CC2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20?,26-,28+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

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UniChem

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Article
PubMed
n/an/a 1n/an/an/an/an/an/a



The University of Sydney

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-tagged LRRK2 after 1 hr by TR-FRET assay


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM50428716
PNG
(CHEMBL2333128)
Show SMILES C[C@@H](Nc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)C(N)=O)C1CC1
Show InChI InChI=1S/C21H22N4O3S/c1-12(13-3-4-13)23-19-17-10-7-15(11-18(17)24-25-20(19)21(22)26)14-5-8-16(9-6-14)29(2,27)28/h5-13H,3-4H2,1-2H3,(H2,22,26)(H,23,24)/t12-/m1/s1
PDB

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PubMed
n/an/a 1n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of wild type GST-tagged LRRK2 (970 to 2527 amino acid residues) (unknown origin) assessed as inhibition of biotinylated-LRRKtide phosphory...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM50428717
PNG
(CHEMBL2333127)
Show SMILES CC[C@@H](C)Nc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)C(N)=O
Show InChI InChI=1S/C20H22N4O3S/c1-4-12(2)22-18-16-10-7-14(11-17(16)23-24-19(18)20(21)25)13-5-8-15(9-6-13)28(3,26)27/h5-12H,4H2,1-3H3,(H2,21,25)(H,22,23)/t12-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

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PubMed
n/an/a 1n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of wild type GST-tagged LRRK2 (970 to 2527 amino acid residues) (unknown origin) assessed as inhibition of biotinylated-LRRKtide phosphory...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM50428701
PNG
(CHEMBL2333115)
Show SMILES CC(C)Nc1c(nnc2ccc(cc12)-c1cn[nH]c1)C(N)=O
Show InChI InChI=1S/C15H16N6O/c1-8(2)19-13-11-5-9(10-6-17-18-7-10)3-4-12(11)20-21-14(13)15(16)22/h3-8H,1-2H3,(H2,16,22)(H,17,18)(H,19,20)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
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CHEMBL
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PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of wild type GST-tagged LRRK2 (970 to 2527 amino acid residues) (unknown origin) assessed as inhibition of biotinylated-LRRKtide phosphory...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM239234
PNG
(US9416126, D50)
Show SMILES CC(C)Oc1cc2c(n[nH]c2cc1F)-c1cc(ncn1)N1CCN(C)[C@@H](C)C1
GoogleScholar
AffyNet 
PC sid
UniChem
AffyNet 
US Patent
n/an/a 1.20n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound(98 μM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well b...


US Patent US9416126 (2016)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM239539
PNG
(US9416126, U23)
Show SMILES COc1ccncc1-c1ccc2[nH]nc(-c3cc(ncn3)N3CCN(CC3)C(C)C)c2c1
GoogleScholar
AffyNet 
PC sid
UniChem
AffyNet 
US Patent
n/an/a 1.26n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound(98 μM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well b...


US Patent US9416126 (2016)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM239235
PNG
(US9416126, D51)
Show SMILES CC(C)Oc1cc2c(n[nH]c2cc1F)-c1cc(ncn1)N1CCN(C)[C@H](C)C1
GoogleScholar
AffyNet 
PC sid
UniChem
AffyNet 
US Patent
n/an/a 1.30n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound(98 μM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well b...


US Patent US9416126 (2016)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM239256
PNG
(US9416126, D72)
Show SMILES CC(C)Oc1cc2c(n[nH]c2cc1F)-c1cc(ncn1)N1C[C@H](C)N(C)[C@H](C)C1
GoogleScholar
AffyNet 
PC sid
UniChem
AffyNet 
US Patent
n/an/a 1.33n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound(98 μM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well b...


US Patent US9416126 (2016)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM239543
PNG
(US9416126, U27)
Show SMILES C[C@H]1CN(C[C@@H](C)O1)c1cc(ncn1)-c1n[nH]c2ccc(cc12)-c1cn[nH]c1
GoogleScholar
AffyNet 
PC sid
UniChem
AffyNet 
US Patent
n/an/a 1.35n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound(98 μM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well b...


US Patent US9416126 (2016)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM239186
PNG
(US9416126, A11)
Show SMILES C[C@H]1CN(C[C@@H](C)O1)c1cc(ncn1)-c1n[nH]c2ccc(cc12)-c1cnn(C)c1
GoogleScholar
AffyNet 
PC sid
UniChem
AffyNet 
US Patent
n/an/a 1.40n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound(98 μM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well b...


US Patent US9416126 (2016)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM239544
PNG
(US9416126, U28)
Show SMILES C[C@H]1CN(C[C@@H](C)O1)c1cc(ncn1)-c1n[nH]c2ccc(cc12)-c1ccn[nH]1
GoogleScholar
AffyNet 
PC sid
UniChem
AffyNet 
US Patent
n/an/a 1.44n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound(98 μM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well b...


US Patent US9416126 (2016)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM239484
PNG
(US9416126, P16)
Show SMILES COCCn1cc(cn1)-c1ccc2[nH]nc(-c3cc(ncn3)N3CCOCC3)c2c1
GoogleScholar
AffyNet 
PC sid
UniChem
AffyNet 
US Patent
n/an/a 1.5n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound(98 μM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well b...


US Patent US9416126 (2016)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM239536
PNG
(US9416126, U20)
Show SMILES COc1ccncc1-c1ccc2[nH]nc(-c3cc(ncn3)N3CCN(CC3)S(C)(=O)=O)c2c1
GoogleScholar
AffyNet 
PC sid
UniChem
AffyNet 
US Patent
n/an/a 1.58n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound(98 μM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well b...


US Patent US9416126 (2016)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM239255
PNG
(US9416126, D71)
Show SMILES COCCN1CCN(CC1=O)c1cc(ncn1)-c1n[nH]c2cc(F)c(OC(C)C)cc12
GoogleScholar
AffyNet 
PC sid
UniChem
AffyNet 
US Patent
n/an/a 1.63n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound(98 μM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well b...


US Patent US9416126 (2016)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM239533
PNG
(US9416126, U17)
Show SMILES O=C1CCCC(=C1)c1ccc2[nH]nc(-c3cc(ncn3)N3CCOCC3)c2c1
GoogleScholar
AffyNet 
PC sid
UniChem
AffyNet 
US Patent
n/an/a 1.63n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound(98 μM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well b...


US Patent US9416126 (2016)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM239527
PNG
(US9416126, U11)
Show SMILES CC1(C)CC(=O)C=C(C1)c1ccc2[nH]nc(-c3cc(ncn3)N3CCOCC3)c2c1
GoogleScholar
AffyNet 
PC sid
UniChem
AffyNet 
US Patent
n/an/a 1.63n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound(98 μM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well b...


US Patent US9416126 (2016)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM239246
PNG
(US9416126, D62)
Show SMILES CC(C)Oc1cc2c(n[nH]c2cc1F)-c1cc(ncn1)N1CCN(CCO)CC1
GoogleScholar
AffyNet 
PC sid
UniChem
AffyNet 
US Patent
n/an/a 1.65n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound(98 μM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well b...


US Patent US9416126 (2016)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM239300
PNG
(US9416126, H5)
Show SMILES COC[C@H](C)Oc1ccc2[nH]nc(-c3cc(ncn3)N3C[C@H](C)O[C@H](C)C3)c2c1
GoogleScholar
AffyNet 
PC sid
UniChem
AffyNet 
US Patent
n/an/a 1.70n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound(98 μM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well b...


US Patent US9416126 (2016)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM239529
PNG
(US9416126, U13)
Show SMILES COc1ccncc1-c1ccc2[nH]nc(-c3cc(ncn3)N3CCOCC3)c2c1
GoogleScholar
AffyNet 
PC sid
UniChem
AffyNet 
US Patent
n/an/a 1.72n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound(98 μM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well b...


US Patent US9416126 (2016)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM239500
PNG
(US9416126, Q14)
Show SMILES COCCn1cc(cn1)-c1ccc2[nH]nc(-c3cc(ncn3)N3C[C@H](C)O[C@H](C)C3)c2c1
GoogleScholar
AffyNet 
PC sid
UniChem
AffyNet 
US Patent
n/an/a 1.80n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound(98 μM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well b...


US Patent US9416126 (2016)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM239184
PNG
(US9416126, A9)
Show SMILES COCCOC1CCN(CC1)c1cc(ncn1)-c1n[nH]c2ccc(cc12)-c1cnn(C)c1
GoogleScholar
AffyNet 
PC sid
UniChem
AffyNet 
US Patent
n/an/a 1.87n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound(98 μM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well b...


US Patent US9416126 (2016)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM239399
PNG
(US9416126, M9)
Show SMILES C[C@@H]1CN(CCO1)c1cc(ncn1)-c1n[nH]c2ccc(cc12)-c1cnn(C)c1
GoogleScholar
AffyNet 
PC sid
UniChem
AffyNet 
US Patent
n/an/a 1.90n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound(98 μM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well b...


US Patent US9416126 (2016)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM50059318
PNG
(CHEMBL3393356 | US9156845, 78)
Show SMILES Fc1c(cccc1-c1c[nH]c2ncnc(N3CCOCC3)c12)C#N
Show InChI InChI=1S/C17H14FN5O/c18-15-11(8-19)2-1-3-12(15)13-9-20-16-14(13)17(22-10-21-16)23-4-6-24-7-5-23/h1-3,9-10H,4-7H2,(H,20,21,22)
PDB

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UniProtKB/SwissProt

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PC sid
UniChem

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AffyNet 
US Patent
n/an/a 2n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM50428703
PNG
(CHEMBL2333113)
Show SMILES C[C@@H](Nc1c(nnc2cc(ccc12)-c1ccncc1)C(N)=O)C1CC1
Show InChI InChI=1S/C19H19N5O/c1-11(12-2-3-12)22-17-15-5-4-14(13-6-8-21-9-7-13)10-16(15)23-24-18(17)19(20)25/h4-12H,2-3H2,1H3,(H2,20,25)(H,22,23)/t11-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
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CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 2n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of wild type GST-tagged LRRK2 (970 to 2527 amino acid residues) (unknown origin) assessed as inhibition of biotinylated-LRRKtide phosphory...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM239180
PNG
(US9416126, A4)
Show SMILES Cn1cc(cn1)-c1ccc2[nH]nc(-c3cc(ncn3)N3CCOC4(CC4)C3)c2c1
GoogleScholar
AffyNet 
PC sid
UniChem
AffyNet 
US Patent
n/an/a 2.01n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound(98 μM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well b...


US Patent US9416126 (2016)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM239309
PNG
(US9416126, H14)
Show SMILES COC[C@H](C)Oc1ccc2[nH]nc(-c3cc(ncn3)N3CCC4(CCCO4)CC3)c2c1
GoogleScholar
AffyNet 
PC sid
UniChem
AffyNet 
US Patent
n/an/a 2.02n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound(98 μM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well b...


US Patent US9416126 (2016)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM239309
PNG
(US9416126, H14)
Show SMILES COC[C@H](C)Oc1ccc2[nH]nc(-c3cc(ncn3)N3CCC4(CCCO4)CC3)c2c1
GoogleScholar
AffyNet 
PC sid
UniChem
AffyNet 
US Patent
n/an/a 2.02n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound(98 μM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well b...


US Patent US9416126 (2016)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM239187
PNG
(US9416126, A12)
Show SMILES COC1CCN(CC1)c1cc(ncn1)-c1n[nH]c2ccc(cc12)-c1cnn(C)c1
GoogleScholar
AffyNet 
PC sid
UniChem
AffyNet 
US Patent
n/an/a 2.04n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound(98 μM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well b...


US Patent US9416126 (2016)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM239302
PNG
(US9416126, H7)
Show SMILES COC[C@H](C)Oc1ccc2[nH]nc(-c3cc(ncn3)N3CCN(C)CC3)c2c1
GoogleScholar
AffyNet 
PC sid
UniChem
AffyNet 
US Patent
n/an/a 2.08n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound(98 μM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well b...


US Patent US9416126 (2016)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM239251
PNG
(US9416126, D67)
Show SMILES COCCOC1CCN(CC1)c1cc(ncn1)-c1n[nH]c2cc(F)c(OC(C)C)cc12
GoogleScholar
AffyNet 
PC sid
UniChem
AffyNet 
US Patent
n/an/a 2.10n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound(98 μM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well b...


US Patent US9416126 (2016)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM239522
PNG
(US9416126, U6)
Show SMILES FC1(F)CCN(CC1)c1cc(ncn1)-c1n[nH]c2ccc(cc12)-c1cc[nH]n1
GoogleScholar
AffyNet 
PC sid
UniChem
AffyNet 
US Patent
n/an/a 2.16n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound(98 μM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well b...


US Patent US9416126 (2016)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM239254
PNG
(US9416126, D70)
Show SMILES CC(C)Oc1cc2c(n[nH]c2cc1F)-c1cc(ncn1)N1CCN(C)C(=O)C1
GoogleScholar
AffyNet 
PC sid
UniChem
AffyNet 
US Patent
n/an/a 2.19n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound(98 μM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well b...


US Patent US9416126 (2016)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM239240
PNG
(US9416126, D56)
Show SMILES CC(C)Oc1cc2c(n[nH]c2cc1F)-c1cc(ncn1)N1CCN(CC1)c1cnn(C)c1
GoogleScholar
AffyNet 
PC sid
UniChem
AffyNet 
US Patent
n/an/a 2.19n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound(98 μM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well b...


US Patent US9416126 (2016)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM239392
PNG
(US9416126, M2)
Show SMILES Cn1cc(cn1)-c1ccc2[nH]nc(-c3cc(ncn3)N3CCCC(F)(F)C3)c2c1
GoogleScholar
AffyNet 
PC sid
UniChem
AffyNet 
US Patent
n/an/a 2.20n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound(98 μM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well b...


US Patent US9416126 (2016)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM239402
PNG
(US9416126, M12)
Show SMILES C[C@H]1CN(CCO1)c1cc(ncn1)-c1n[nH]c2ccc(cc12)-c1cnn(C)c1
GoogleScholar
AffyNet 
PC sid
UniChem
AffyNet 
US Patent
n/an/a 2.20n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound(98 μM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well b...


US Patent US9416126 (2016)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM239490
PNG
(US9416126, Q4)
Show SMILES C[C@H]1CN(C[C@@H](C)O1)c1cc(ncn1)-c1n[nH]c2ccc(cc12)-c1cncc(C)c1
GoogleScholar
AffyNet 
PC sid
UniChem
AffyNet 
US Patent
n/an/a 2.20n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound(98 μM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well b...


US Patent US9416126 (2016)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM239526
PNG
(US9416126, U10)
Show SMILES Cc1ncc(s1)-c1ccc2[nH]nc(-c3cc(ncn3)N3CCOCC3)c2c1
GoogleScholar
AffyNet 
PC sid
UniChem
AffyNet 
US Patent
n/an/a 2.20n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound(98 μM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well b...


US Patent US9416126 (2016)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM239252
PNG
(US9416126, D68)
Show SMILES CCS(=O)(=O)N1CCN(CC1)c1cc(ncn1)-c1n[nH]c2cc(F)c(OC(C)C)cc12
GoogleScholar
AffyNet 
PC sid
UniChem
AffyNet 
US Patent
n/an/a 2.24n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound(98 μM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well b...


US Patent US9416126 (2016)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM239439
PNG
(US9416126, N20)
Show SMILES CC(C)Oc1cc2c(n[nH]c2cc1F)-c1cc(ncn1)N1CCC(F)(CO)CC1
GoogleScholar
AffyNet 
PC sid
UniChem
AffyNet 
US Patent
n/an/a 2.30n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound(98 μM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well b...


US Patent US9416126 (2016)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM239394
PNG
(US9416126, M4)
Show SMILES Cn1cc(cn1)-c1ccc2[nH]nc(-c3cc(ncn3)N3CC[C@@H](CF)C3)c2c1
GoogleScholar
AffyNet 
PC sid
UniChem
AffyNet 
US Patent
n/an/a 2.30n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound(98 μM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well b...


US Patent US9416126 (2016)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM239396
PNG
(US9416126, M6)
Show SMILES CC(O)C1CCN(C1)c1cc(ncn1)-c1n[nH]c2ccc(cc12)-c1cnn(C)c1
GoogleScholar
AffyNet 
PC sid
UniChem
AffyNet 
US Patent
n/an/a 2.30n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound(98 μM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well b...


US Patent US9416126 (2016)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM239532
PNG
(US9416126, U16)
Show SMILES C1CN(CCO1)c1cc(ncn1)-c1n[nH]c2ccc(cc12)-c1cn[nH]c1
GoogleScholar
AffyNet 
PC sid
UniChem
AffyNet 
US Patent
n/an/a 2.30n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound(98 μM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well b...


US Patent US9416126 (2016)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM239087
PNG
(US9416126, D32)
Show SMILES CC(C)Oc1ccc2[nH]nc(-c3cc(ncn3)N3CCC4(CCNC4=O)CC3)c2c1
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/a 2.31n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound(98 μM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well b...


US Patent US9416126 (2016)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM239080
PNG
(US9416126, A1)
Show SMILES Cn1cc(cn1)-c1ccc2[nH]nc(-c3cc(ncn3)N3CCOCC3)c2c1
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/a 2.31n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound(98 μM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well b...


US Patent US9416126 (2016)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM239541
PNG
(US9416126, U25)
Show SMILES CC(C)N1CCN(CC1)c1cc(ncn1)-c1n[nH]c2ccc(cc12)-c1ccn[nH]1
GoogleScholar
AffyNet 
PC sid
UniChem
AffyNet 
US Patent
n/an/a 2.34n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound(98 μM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well b...


US Patent US9416126 (2016)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM239212
PNG
(US9416126, D26)
Show SMILES CC(C)Oc1cc2c(n[nH]c2cc1F)-c1cc(ncn1)N1CCOCC1
GoogleScholar
AffyNet 
PC sid
UniChem
AffyNet 
US Patent
n/an/a 2.39n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound(98 μM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well b...


US Patent US9416126 (2016)

More data for this
Ligand-Target Pair
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