BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 242 hits Enz. Inhib. hit(s) with Target = 'Leucine-rich repeat serine/threonine-protein kinase 2 G2019S'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM254932
PNG
(US9499542, 15)
Show SMILES Cc1cc(ccc1CN1CCOCC1)-c1cc(Nc2ccn(C)n2)nc2[nH]cc(C#N)c12
Show InChI InChI=1S/C24H25N7O/c1-16-11-17(3-4-18(16)15-31-7-9-32-10-8-31)20-12-22(27-21-5-6-30(2)29-21)28-24-23(20)19(13-25)14-26-24/h3-6,11-12,14H,7-10,15H2,1-2H3,(H2,26,27,28,29)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/a 1n/an/an/an/an/an/a



H. Lundbeck A/S; Vernalis (R&D) Ltd.

US Patent


Assay Description
LRRK2 kinase activity is measured using a LanthaScreen kinase activity assay available from Invitrogen (Life Technologies Corporation). The assay is ...


US Patent US9499542 (2016)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM254931
PNG
(US9499542, 14)
Show SMILES Cc1cccc(c1)-c1cc(Nc2ccn(C)n2)nc2[nH]cc(C#N)c12
Show InChI InChI=1S/C19H16N6/c1-12-4-3-5-13(8-12)15-9-17(22-16-6-7-25(2)24-16)23-19-18(15)14(10-20)11-21-19/h3-9,11H,1-2H3,(H2,21,22,23,24)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/a 2n/an/an/an/an/an/a



H. Lundbeck A/S; Vernalis (R&D) Ltd.

US Patent


Assay Description
LRRK2 kinase activity is measured using a LanthaScreen kinase activity assay available from Invitrogen (Life Technologies Corporation). The assay is ...


US Patent US9499542 (2016)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM50059318
PNG
(CHEMBL3393356 | US9156845, 78)
Show SMILES Fc1c(cccc1-c1c[nH]c2ncnc(N3CCOCC3)c12)C#N
Show InChI InChI=1S/C17H14FN5O/c18-15-11(8-19)2-1-3-12(15)13-9-20-16-14(13)17(22-10-21-16)23-4-6-24-7-5-23/h1-3,9-10H,4-7H2,(H,20,21,22)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 7n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185413
PNG
(US9156845, 57)
Show SMILES C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3ccc(cc3)C(N)=O)c12
Show InChI InChI=1/C19H21N5O/c1-12-3-2-8-24(10-12)19-16-15(9-21-18(16)22-11-23-19)13-4-6-14(7-5-13)17(20)25/h4-7,9,11-12H,2-3,8,10H2,1H3,(H2,20,25)(H,21,22,23)/t12-/s2
PDB

GoogleScholar
AffyNet 
UniChem

Similars

AffyNet 
US Patent
n/an/a 9n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185444
PNG
(US9156845, 94)
Show SMILES COc1ccc(F)cc1-c1c[nH]c2ncnc(N3CCOCC3)c12
Show InChI InChI=1S/C17H17FN4O2/c1-23-14-3-2-11(18)8-12(14)13-9-19-16-15(13)17(21-10-20-16)22-4-6-24-7-5-22/h2-3,8-10H,4-7H2,1H3,(H,19,20,21)
PDB

GoogleScholar
AffyNet 
UniChem

Similars

AffyNet 
US Patent
n/an/a 10n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM50059277
PNG
(CHEMBL3393348 | US9156845, 4)
Show SMILES N#Cc1cccc(c1)-c1c[nH]c2ncnc(N3CCOCC3)c12
Show InChI InChI=1S/C17H15N5O/c18-9-12-2-1-3-13(8-12)14-10-19-16-15(14)17(21-11-20-16)22-4-6-23-7-5-22/h1-3,8,10-11H,4-7H2,(H,19,20,21)
PDB

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
PDB
UniChem

Similars

AffyNet 
US Patent
n/an/a 11n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185529
PNG
(US9156845, 183)
Show SMILES COc1ccc(F)cc1-c1c[nH]c2ncnc(N(C)C)c12
Show InChI InChI=1S/C15H15FN4O/c1-20(2)15-13-11(7-17-14(13)18-8-19-15)10-6-9(16)4-5-12(10)21-3/h4-8H,1-3H3,(H,17,18,19)
PDB

GoogleScholar
AffyNet 
UniChem

Similars

AffyNet 
US Patent
n/an/a 11n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185414
PNG
(US9156845, 58)
Show SMILES C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3cccc(O)c3)c12
Show InChI InChI=1/C18H20N4O/c1-12-4-3-7-22(10-12)18-16-15(9-19-17(16)20-11-21-18)13-5-2-6-14(23)8-13/h2,5-6,8-9,11-12,23H,3-4,7,10H2,1H3,(H,19,20,21)/t12-/s2
PDB

GoogleScholar
AffyNet 
UniChem

Similars

AffyNet 
US Patent
n/an/a 12n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185439
PNG
(US9156845, 88)
Show SMILES Fc1ccc(Cl)cc1-c1c[nH]c2ncnc(N3CCOCC3)c12
Show InChI InChI=1S/C16H14ClFN4O/c17-10-1-2-13(18)11(7-10)12-8-19-15-14(12)16(21-9-20-15)22-3-5-23-6-4-22/h1-2,7-9H,3-6H2,(H,19,20,21)
PDB

GoogleScholar
AffyNet 
UniChem

Similars

AffyNet 
US Patent
n/an/a 12n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185374
PNG
(US9156845, 17)
Show SMILES C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3cnn(C)c3)c12
Show InChI InChI=1/C16H20N6/c1-11-4-3-5-22(8-11)16-14-13(12-6-20-21(2)9-12)7-17-15(14)18-10-19-16/h6-7,9-11H,3-5,8H2,1-2H3,(H,17,18,19)/t11-/s2
PDB

GoogleScholar
AffyNet 
UniChem

Similars

AffyNet 
US Patent
n/an/a 12n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185553
PNG
(US9156845, 212)
Show SMILES C1CN(CCO1)c1ncnc2[nH]cc(-c3cnc4cccnn34)c12
Show InChI InChI=1S/C16H15N7O/c1-2-13-17-9-12(23(13)21-3-1)11-8-18-15-14(11)16(20-10-19-15)22-4-6-24-7-5-22/h1-3,8-10H,4-7H2,(H,18,19,20)
PDB

GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 12.3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM50059345
PNG
(CHEMBL3393355 | US9156845, 83)
Show SMILES Clc1cccc(c1)-c1c[nH]c2ncnc(N3CCOCC3)c12
Show InChI InChI=1S/C16H15ClN4O/c17-12-3-1-2-11(8-12)13-9-18-15-14(13)16(20-10-19-15)21-4-6-22-7-5-21/h1-3,8-10H,4-7H2,(H,18,19,20)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 13n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185558
PNG
(US9156845, 217)
Show SMILES Cn1cc(cc1C#N)-c1c[nH]c2ncnc(N3CCOCC3)c12
Show InChI InChI=1S/C16H16N6O/c1-21-9-11(6-12(21)7-17)13-8-18-15-14(13)16(20-10-19-15)22-2-4-23-5-3-22/h6,8-10H,2-5H2,1H3,(H,18,19,20)
PDB

GoogleScholar
AffyNet 
UniChem

Similars

AffyNet 
US Patent
n/an/a 13n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185404
PNG
(US9156845, 48)
Show SMILES C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3cccc4[nH]ncc34)c12
Show InChI InChI=1/C19H20N6/c1-12-4-3-7-25(10-12)19-17-15(8-20-18(17)21-11-22-19)13-5-2-6-16-14(13)9-23-24-16/h2,5-6,8-9,11-12H,3-4,7,10H2,1H3,(H,23,24)(H,20,21,22)/t12-/s2
PDB

GoogleScholar
AffyNet 
UniChem

Similars

AffyNet 
US Patent
n/an/a 14n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185454
PNG
(US9156845, 105)
Show SMILES Brc1cncc(c1)-c1c[nH]c2ncnc(N3CCOCC3)c12
Show InChI InChI=1S/C15H14BrN5O/c16-11-5-10(6-17-7-11)12-8-18-14-13(12)15(20-9-19-14)21-1-3-22-4-2-21/h5-9H,1-4H2,(H,18,19,20)
PDB

GoogleScholar
AffyNet 
UniChem

Similars

AffyNet 
US Patent
n/an/a 14n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM50059347
PNG
(CHEMBL3393353 | US9156845, 93)
Show SMILES C1CN(CCO1)c1ncnc2[nH]cc(-c3ccccc3)c12
Show InChI InChI=1S/C16H16N4O/c1-2-4-12(5-3-1)13-10-17-15-14(13)16(19-11-18-15)20-6-8-21-9-7-20/h1-5,10-11H,6-9H2,(H,17,18,19)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 14n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185560
PNG
(US9156845, 220)
Show SMILES Cn1cc(nc1C#N)-c1c[nH]c2ncnc(N3CCOCC3)c12
Show InChI InChI=1S/C15H15N7O/c1-21-8-11(20-12(21)6-16)10-7-17-14-13(10)15(19-9-18-14)22-2-4-23-5-3-22/h7-9H,2-5H2,1H3,(H,17,18,19)
PDB

GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 14.7n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM50059301
PNG
(CHEMBL3393346 | US9156845, 5)
Show SMILES CN(C)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12
Show InChI InChI=1S/C15H13N5/c1-20(2)15-13-12(8-17-14(13)18-9-19-15)11-5-3-4-10(6-11)7-16/h3-6,8-9H,1-2H3,(H,17,18,19)
PDB

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 15n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185379
PNG
(US9156845, 22)
Show SMILES C[C@H]1C[C@@H](C)CN(C1)c1ncnc2[nH]cc(-c3cnn(C)c3)c12
Show InChI InChI=1/C17H22N6/c1-11-4-12(2)8-23(7-11)17-15-14(13-5-21-22(3)9-13)6-18-16(15)19-10-20-17/h5-6,9-12H,4,7-8H2,1-3H3,(H,18,19,20)/t11-,12+
PDB

GoogleScholar
AffyNet 
UniChem

Similars

AffyNet 
US Patent
n/an/a 16n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM254929
PNG
(US9499542, 12)
Show SMILES Cc1cccc(c1)-c1cc(N)nc2[nH]cc(C#N)c12
Show InChI InChI=1S/C15H12N4/c1-9-3-2-4-10(5-9)12-6-13(17)19-15-14(12)11(7-16)8-18-15/h2-6,8H,1H3,(H3,17,18,19)
PDB

GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 17n/an/an/an/an/an/a



H. Lundbeck A/S; Vernalis (R&D) Ltd.

US Patent


Assay Description
LRRK2 kinase activity is measured using a LanthaScreen kinase activity assay available from Invitrogen (Life Technologies Corporation). The assay is ...


US Patent US9499542 (2016)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185425
PNG
(US9156845, 69)
Show SMILES CN(C)c1ncnc2[nH]cc(-c3cccc(C#N)c3F)c12
Show InChI InChI=1S/C15H12FN5/c1-21(2)15-12-11(7-18-14(12)19-8-20-15)10-5-3-4-9(6-17)13(10)16/h3-5,7-8H,1-2H3,(H,18,19,20)
PDB

GoogleScholar
AffyNet 
UniChem

Similars

AffyNet 
US Patent
n/an/a 17n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185571
PNG
(US9156845, 7)
Show SMILES C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3cccc(CO)c3)c12
Show InChI InChI=1S/C19H22N4O/c1-13-4-3-7-23(10-13)19-17-16(9-20-18(17)21-12-22-19)15-6-2-5-14(8-15)11-24/h2,5-6,8-9,12-13,24H,3-4,7,10-11H2,1H3,(H,20,21,22)/t13-/m0/s1
PDB

GoogleScholar
AffyNet 
UniChem

Similars

AffyNet 
US Patent
n/an/a 18n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185382
PNG
(US9156845, 25)
Show SMILES COc1ccc(Cl)cc1-c1c[nH]c2ncnc(N(C)C)c12
Show InChI InChI=1S/C15H15ClN4O/c1-20(2)15-13-11(7-17-14(13)18-8-19-15)10-6-9(16)4-5-12(10)21-3/h4-8H,1-3H3,(H,17,18,19)
PDB

GoogleScholar
AffyNet 
UniChem

Similars

AffyNet 
US Patent
n/an/a 19n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185408
PNG
(US9156845, 52)
Show SMILES C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3cncc(C)c3)c12
Show InChI InChI=1/C18H21N5/c1-12-4-3-5-23(10-12)18-16-15(9-20-17(16)21-11-22-18)14-6-13(2)7-19-8-14/h6-9,11-12H,3-5,10H2,1-2H3,(H,20,21,22)/t12-/s2
PDB

GoogleScholar
AffyNet 
UniChem

Similars

AffyNet 
US Patent
n/an/a 19n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185449
PNG
(US9156845, 100)
Show SMILES OCc1cccc(c1)-c1c[nH]c2ncnc(N3CCOCC3)c12
Show InChI InChI=1S/C17H18N4O2/c22-10-12-2-1-3-13(8-12)14-9-18-16-15(14)17(20-11-19-16)21-4-6-23-7-5-21/h1-3,8-9,11,22H,4-7,10H2,(H,18,19,20)
PDB

GoogleScholar
AffyNet 
UniChem

Similars

AffyNet 
US Patent
n/an/a 19n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185456
PNG
(US9156845, 107)
Show SMILES Cc1cccc(c1)-c1c[nH]c2ncnc(N3CCOCC3)c12
Show InChI InChI=1S/C17H18N4O/c1-12-3-2-4-13(9-12)14-10-18-16-15(14)17(20-11-19-16)21-5-7-22-8-6-21/h2-4,9-11H,5-8H2,1H3,(H,18,19,20)
PDB

GoogleScholar
AffyNet 
UniChem

Similars

AffyNet 
US Patent
n/an/a 20n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185436
PNG
(US9156845, 85)
Show SMILES COc1cc(F)cc(c1)-c1c[nH]c2ncnc(N3CCOCC3)c12
Show InChI InChI=1S/C17H17FN4O2/c1-23-13-7-11(6-12(18)8-13)14-9-19-16-15(14)17(21-10-20-16)22-2-4-24-5-3-22/h6-10H,2-5H2,1H3,(H,19,20,21)
PDB

GoogleScholar
AffyNet 
UniChem

Similars

AffyNet 
US Patent
n/an/a 20n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185476
PNG
(US9156845, 129)
Show SMILES NC1CCCN(C1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12
Show InChI InChI=1/C18H18N6/c19-8-12-3-1-4-13(7-12)15-9-21-17-16(15)18(23-11-22-17)24-6-2-5-14(20)10-24/h1,3-4,7,9,11,14H,2,5-6,10,20H2,(H,21,22,23)
PDB

GoogleScholar
AffyNet 
UniChem

Similars

AffyNet 
US Patent
n/an/a 21n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185442
PNG
(US9156845, 91)
Show SMILES Fc1cccc(c1)-c1c[nH]c2ncnc(N3CCOCC3)c12
Show InChI InChI=1S/C16H15FN4O/c17-12-3-1-2-11(8-12)13-9-18-15-14(13)16(20-10-19-15)21-4-6-22-7-5-21/h1-3,8-10H,4-7H2,(H,18,19,20)
PDB

GoogleScholar
AffyNet 
UniChem

Similars

AffyNet 
US Patent
n/an/a 21n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185531
PNG
(US9156845, 185)
Show SMILES COc1ccc(F)cc1-c1c[nH]c2ncnc(N3CC[C@H](F)C3)c12
Show InChI InChI=1/C17H16F2N4O/c1-24-14-3-2-10(18)6-12(14)13-7-20-16-15(13)17(22-9-21-16)23-5-4-11(19)8-23/h2-3,6-7,9,11H,4-5,8H2,1H3,(H,20,21,22)/t11-/s2
PDB

GoogleScholar
AffyNet 
UniChem

Similars

AffyNet 
US Patent
n/an/a 23n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185574
PNG
(US9156845, 10)
Show SMILES CN(C)c1ncnc2[nH]cc(-c3cccc(CO)c3)c12
Show InChI InChI=1S/C15H16N4O/c1-19(2)15-13-12(7-16-14(13)17-9-18-15)11-5-3-4-10(6-11)8-20/h3-7,9,20H,8H2,1-2H3,(H,16,17,18)
PDB

GoogleScholar
AffyNet 
UniChem

Similars

AffyNet 
US Patent
n/an/a 23n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185450
PNG
(US9156845, 101)
Show SMILES COc1ccccc1-c1c[nH]c2ncnc(N3CCOCC3)c12
Show InChI InChI=1S/C17H18N4O2/c1-22-14-5-3-2-4-12(14)13-10-18-16-15(13)17(20-11-19-16)21-6-8-23-9-7-21/h2-5,10-11H,6-9H2,1H3,(H,18,19,20)
PDB

GoogleScholar
AffyNet 
UniChem

Similars

AffyNet 
US Patent
n/an/a 23n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185527
PNG
(US9156845, 181)
Show SMILES COc1ccc(F)cc1-c1c[nH]c2ncnc(N3CCCC(F)C3)c12
Show InChI InChI=1/C18H18F2N4O/c1-25-15-5-4-11(19)7-13(15)14-8-21-17-16(14)18(23-10-22-17)24-6-2-3-12(20)9-24/h4-5,7-8,10,12H,2-3,6,9H2,1H3,(H,21,22,23)
PDB

GoogleScholar
AffyNet 
UniChem

Similars

AffyNet 
US Patent
n/an/a 24n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185438
PNG
(US9156845, 87)
Show SMILES Fc1cccc(-c2c[nH]c3ncnc(N4CCOCC4)c23)c1F
Show InChI InChI=1S/C16H14F2N4O/c17-12-3-1-2-10(14(12)18)11-8-19-15-13(11)16(21-9-20-15)22-4-6-23-7-5-22/h1-3,8-9H,4-7H2,(H,19,20,21)
PDB

GoogleScholar
AffyNet 
UniChem

Similars

AffyNet 
US Patent
n/an/a 24n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM254926
PNG
(US9499542, 9)
Show SMILES CCc1cc(ccc1CN1CCOCC1)-c1ccnc2[nH]cc(C#N)c12
Show InChI InChI=1S/C21H22N4O/c1-2-15-11-16(3-4-17(15)14-25-7-9-26-10-8-25)19-5-6-23-21-20(19)18(12-22)13-24-21/h3-6,11,13H,2,7-10,14H2,1H3,(H,23,24)
PDB

GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 26n/an/an/an/an/an/a



H. Lundbeck A/S; Vernalis (R&D) Ltd.

US Patent


Assay Description
LRRK2 kinase activity is measured using a LanthaScreen kinase activity assay available from Invitrogen (Life Technologies Corporation). The assay is ...


US Patent US9499542 (2016)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM50059314
PNG
(CHEMBL3393359 | US9156845, 3)
Show SMILES N#Cc1cccc(n1)-c1c[nH]c2ncnc(N3CCOCC3)c12
Show InChI InChI=1S/C16H14N6O/c17-8-11-2-1-3-13(21-11)12-9-18-15-14(12)16(20-10-19-15)22-4-6-23-7-5-22/h1-3,9-10H,4-7H2,(H,18,19,20)
PDB

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 26n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185535
PNG
(US9156845, 189)
Show SMILES COc1cccc(F)c1-c1c[nH]c2ncnc(N(C)C)c12
Show InChI InChI=1S/C15H15FN4O/c1-20(2)15-13-9(7-17-14(13)18-8-19-15)12-10(16)5-4-6-11(12)21-3/h4-8H,1-3H3,(H,17,18,19)
PDB

GoogleScholar
AffyNet 
UniChem

Similars

AffyNet 
US Patent
n/an/a 27n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185485
PNG
(US9156845, 138)
Show SMILES OC1CCCN(C1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12
Show InChI InChI=1/C18H17N5O/c19-8-12-3-1-4-13(7-12)15-9-20-17-16(15)18(22-11-21-17)23-6-2-5-14(24)10-23/h1,3-4,7,9,11,14,24H,2,5-6,10H2,(H,20,21,22)
PDB

GoogleScholar
AffyNet 
UniChem

Similars

AffyNet 
US Patent
n/an/a 27n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185470
PNG
(US9156845, 123)
Show SMILES Cn1cc(cn1)-c1c[nH]c2ncnc(N3CCCC(F)C3)c12
Show InChI InChI=1/C15H17FN6/c1-21-7-10(5-20-21)12-6-17-14-13(12)15(19-9-18-14)22-4-2-3-11(16)8-22/h5-7,9,11H,2-4,8H2,1H3,(H,17,18,19)
PDB

GoogleScholar
AffyNet 
UniChem

Similars

AffyNet 
US Patent
n/an/a 27n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185412
PNG
(US9156845, 56)
Show SMILES C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3ccc(O)cc3)c12
Show InChI InChI=1/C18H20N4O/c1-12-3-2-8-22(10-12)18-16-15(9-19-17(16)20-11-21-18)13-4-6-14(23)7-5-13/h4-7,9,11-12,23H,2-3,8,10H2,1H3,(H,19,20,21)/t12-/s2
PDB

GoogleScholar
AffyNet 
UniChem

Similars

AffyNet 
US Patent
n/an/a 28n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM50059353
PNG
(CHEMBL3393343 | US9156845, 12)
Show SMILES N#Cc1cccc(c1)-c1c[nH]c2ncnc(N3CCCCC3)c12
Show InChI InChI=1S/C18H17N5/c19-10-13-5-4-6-14(9-13)15-11-20-17-16(15)18(22-12-21-17)23-7-2-1-3-8-23/h4-6,9,11-12H,1-3,7-8H2,(H,20,21,22)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 28n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185509
PNG
(US9156845, 163)
Show SMILES COc1ccc(F)cc1-c1c[nH]c2ncnc(N3CCC(F)CC3)c12
Show InChI InChI=1S/C18H18F2N4O/c1-25-15-3-2-12(20)8-13(15)14-9-21-17-16(14)18(23-10-22-17)24-6-4-11(19)5-7-24/h2-3,8-11H,4-7H2,1H3,(H,21,22,23)
PDB

GoogleScholar
AffyNet 
UniChem

Similars

AffyNet 
US Patent
n/an/a 29n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185519
PNG
(US9156845, 173)
Show SMILES COc1ccccc1-c1c[nH]c2ncnc(N(C)C)c12
Show InChI InChI=1S/C15H16N4O/c1-19(2)15-13-11(8-16-14(13)17-9-18-15)10-6-4-5-7-12(10)20-3/h4-9H,1-3H3,(H,16,17,18)
PDB

GoogleScholar
AffyNet 
UniChem

Similars

AffyNet 
US Patent
n/an/a 29n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185376
PNG
(US9156845, 19)
Show SMILES OCC1CCN(CC1)c1ncnc2[nH]cc(-c3ccccc3)c12
Show InChI InChI=1S/C18H20N4O/c23-11-13-6-8-22(9-7-13)18-16-15(14-4-2-1-3-5-14)10-19-17(16)20-12-21-18/h1-5,10,12-13,23H,6-9,11H2,(H,19,20,21)
PDB

GoogleScholar
AffyNet 
UniChem

Similars

AffyNet 
US Patent
n/an/a 29n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM50059312
PNG
(CHEMBL3393441 | US9156845, 149)
Show SMILES Cc1cncc(c1)-c1c[nH]c2ncnc(N3CCOCC3)c12
Show InChI InChI=1S/C16H17N5O/c1-11-6-12(8-17-7-11)13-9-18-15-14(13)16(20-10-19-15)21-2-4-22-5-3-21/h6-10H,2-5H2,1H3,(H,18,19,20)
PDB

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 30n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185415
PNG
(US9156845, 59)
Show SMILES C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3cc(C)cnc3Cl)c12
Show InChI InChI=1/C18H20ClN5/c1-11-4-3-5-24(9-11)18-15-14(8-21-17(15)22-10-23-18)13-6-12(2)7-20-16(13)19/h6-8,10-11H,3-5,9H2,1-2H3,(H,21,22,23)/t11-/s2
PDB

GoogleScholar
AffyNet 
UniChem

Similars

AffyNet 
US Patent
n/an/a 30n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185381
PNG
(US9156845, 24)
Show SMILES COc1ccc(cc1-c1c[nH]c2ncnc(N(C)C)c12)[N+]#[C-]
Show InChI InChI=1S/C16H15N5O/c1-17-10-5-6-13(22-4)11(7-10)12-8-18-15-14(12)16(21(2)3)20-9-19-15/h5-9H,2-4H3,(H,18,19,20)
PDB

GoogleScholar
AffyNet 
UniChem

Similars

AffyNet 
US Patent
n/an/a 30n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185435
PNG
(US9156845, 84)
Show SMILES Fc1ccccc1-c1c[nH]c2ncnc(N3CCOCC3)c12
Show InChI InChI=1S/C16H15FN4O/c17-13-4-2-1-3-11(13)12-9-18-15-14(12)16(20-10-19-15)21-5-7-22-8-6-21/h1-4,9-10H,5-8H2,(H,18,19,20)
PDB

GoogleScholar
AffyNet 
UniChem

Similars

AffyNet 
US Patent
n/an/a 30n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185525
PNG
(US9156845, 179)
Show SMILES COc1ccc(F)cc1-c1c[nH]c2ncnc(N3CCO[C@@H](C)C3)c12
Show InChI InChI=1/C18H19FN4O2/c1-11-9-23(5-6-25-11)18-16-14(8-20-17(16)21-10-22-18)13-7-12(19)3-4-15(13)24-2/h3-4,7-8,10-11H,5-6,9H2,1-2H3,(H,20,21,22)/t11-/s2
PDB

GoogleScholar
AffyNet 
UniChem

Similars

AffyNet 
US Patent
n/an/a 30n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185469
PNG
(US9156845, 122)
Show SMILES C[C@@H]1CN(CCO1)c1ncnc2[nH]cc(-c3cnn(C)c3)c12
Show InChI InChI=1/C15H18N6O/c1-10-7-21(3-4-22-10)15-13-12(11-5-19-20(2)8-11)6-16-14(13)17-9-18-15/h5-6,8-10H,3-4,7H2,1-2H3,(H,16,17,18)/t10-/s2
PDB

GoogleScholar
AffyNet 
UniChem

Similars

AffyNet 
US Patent
n/an/a 31n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 242 total )  |  Next  |  Last  >>
Jump to: