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Compile Data Set for Download or QSAR

Found 387 hits Enz. Inhib. hit(s) with Target = 'Leucyl-cystinyl aminopeptidase'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM271230
PNG
(US10059720, Example 45)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1ccc(cc1)[C@H](N)[C@](O)(Cc1cc(OC2CCCCC2)ccn1)C(O)=O
Show InChI InChI=1S/C28H32N2O6S/c1-37(34,35)25-13-11-20(12-14-25)19-7-9-21(10-8-19)26(29)28(33,27(31)32)18-22-17-24(15-16-30-22)36-23-5-3-2-4-6-23/h7-17,23,26,33H,2-6,18,29H2,1H3,(H,31,32)/t26-,28+/m0/s1
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n/an/a 0.890n/an/an/an/an/an/a



Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM271257
PNG
(US10059720, Example 72)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(OCCC(C)(C)C)c(C)cn1)C(O)=O
Show InChI InChI=1S/C20H34N2O4/c1-13(2)9-17(21)20(25,18(23)24)11-15-10-16(14(3)12-22-15)26-8-7-19(4,5)6/h10,12-13,17,25H,7-9,11,21H2,1-6H3,(H,23,24)/t17-,20+/m0/s1
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n/an/a 0.940n/an/an/an/an/an/a



Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM271275
PNG
(US10059720, Example 90)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(ccn1)N1CCC(C)(C)CC1)C(O)=O
Show InChI InChI=1S/C20H33N3O3/c1-14(2)11-17(21)20(26,18(24)25)13-15-12-16(5-8-22-15)23-9-6-19(3,4)7-10-23/h5,8,12,14,17,26H,6-7,9-11,13,21H2,1-4H3,(H,24,25)/t17-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM271198
PNG
(US10059720, Example 13)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(ccn1)N1CCCCC1)C(O)=O
Show InChI InChI=1S/C18H29N3O3/c1-13(2)10-16(19)18(24,17(22)23)12-14-11-15(6-7-20-14)21-8-4-3-5-9-21/h6-7,11,13,16,24H,3-5,8-10,12,19H2,1-2H3,(H,22,23)/t16-,18+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM271277
PNG
(US10059720, Example 92)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(O[C@H](C)Cc2ccccc2)ccn1)C(O)=O
Show InChI InChI=1S/C22H30N2O4/c1-15(2)11-20(23)22(27,21(25)26)14-18-13-19(9-10-24-18)28-16(3)12-17-7-5-4-6-8-17/h4-10,13,15-16,20,27H,11-12,14,23H2,1-3H3,(H,25,26)/t16-,20+,22-/m1/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM271190
PNG
(US10059720, Example 6)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(O[C@H]2CC[C@H](C)CC2)ccn1)C(O)=O
Show InChI InChI=1S/C20H32N2O4/c1-13(2)10-18(21)20(25,19(23)24)12-15-11-17(8-9-22-15)26-16-6-4-14(3)5-7-16/h8-9,11,13-14,16,18,25H,4-7,10,12,21H2,1-3H3,(H,23,24)/t14-,16-,18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM271272
PNG
(US10059720, Example 87)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(OC2CCN(CC2)C(=O)OCc2ccccc2)ccn1)C(O)=O
Show InChI InChI=1S/C26H35N3O6/c1-18(2)14-23(27)26(33,24(30)31)16-20-15-22(8-11-28-20)35-21-9-12-29(13-10-21)25(32)34-17-19-6-4-3-5-7-19/h3-8,11,15,18,21,23,33H,9-10,12-14,16-17,27H2,1-2H3,(H,30,31)/t23-,26+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM271330
PNG
(US10059720, Example 145)
Show SMILES CCCSC[C@H](N)[C@](O)(Cc1cc(O[C@H]2CC[C@H](C)CC2)ccn1)C(O)=O
Show InChI InChI=1S/C20H32N2O4S/c1-3-10-27-13-18(21)20(25,19(23)24)12-15-11-17(8-9-22-15)26-16-6-4-14(2)5-7-16/h8-9,11,14,16,18,25H,3-7,10,12-13,21H2,1-2H3,(H,23,24)/t14-,16-,18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM271288
PNG
(US10059720, Example 103)
Show SMILES CSC[C@H](N)[C@](O)(Cc1cc(O[C@H]2CC[C@H](C)CC2)ccn1)C(O)=O
Show InChI InChI=1S/C18H28N2O4S/c1-12-3-5-14(6-4-12)24-15-7-8-20-13(9-15)10-18(23,17(21)22)16(19)11-25-2/h7-9,12,14,16,23H,3-6,10-11,19H2,1-2H3,(H,21,22)/t12-,14-,16-,18+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM271232
PNG
(US10059720, Example 47)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(OC2CC3CCC2C3)ccn1)C(O)=O
Show InChI InChI=1S/C20H30N2O4/c1-12(2)7-18(21)20(25,19(23)24)11-15-10-16(5-6-22-15)26-17-9-13-3-4-14(17)8-13/h5-6,10,12-14,17-18,25H,3-4,7-9,11,21H2,1-2H3,(H,23,24)/t13?,14?,17?,18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM271218
PNG
(US10059720, Example 33)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc2n(CCC3CCCCC3)cnc2cn1)C(O)=O
Show InChI InChI=1S/C22H34N4O3/c1-15(2)10-20(23)22(29,21(27)28)12-17-11-19-18(13-24-17)25-14-26(19)9-8-16-6-4-3-5-7-16/h11,13-16,20,29H,3-10,12,23H2,1-2H3,(H,27,28)/t20-,22+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM271280
PNG
(US10059720, Example 95)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(OCCc2ccsc2)ccn1)C(O)=O
Show InChI InChI=1S/C19H26N2O4S/c1-13(2)9-17(20)19(24,18(22)23)11-15-10-16(3-6-21-15)25-7-4-14-5-8-26-12-14/h3,5-6,8,10,12-13,17,24H,4,7,9,11,20H2,1-2H3,(H,22,23)/t17-,19+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM271258
PNG
(US10059720, Example 73)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(O[C@H]2CC[C@H](C)CC2)c(C)cn1)C(O)=O
Show InChI InChI=1S/C21H34N2O4/c1-13(2)9-19(22)21(26,20(24)25)11-16-10-18(15(4)12-23-16)27-17-7-5-14(3)6-8-17/h10,12-14,17,19,26H,5-9,11,22H2,1-4H3,(H,24,25)/t14-,17-,19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM271233
PNG
(US10059720, Example 48)
Show SMILES N[C@@H](c1ccc(cc1)N1CCOCC1)[C@](O)(Cc1cc(OC2CCCCC2)ccn1)C(O)=O
Show InChI InChI=1S/C25H33N3O5/c26-23(18-6-8-20(9-7-18)28-12-14-32-15-13-28)25(31,24(29)30)17-19-16-22(10-11-27-19)33-21-4-2-1-3-5-21/h6-11,16,21,23,31H,1-5,12-15,17,26H2,(H,29,30)/t23-,25+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM271245
PNG
(US10059720, Example 60)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(OC2CC(C)(C)OC(C)(C)C2)ccn1)C(O)=O
Show InChI InChI=1S/C22H36N2O5/c1-14(2)9-18(23)22(27,19(25)26)11-15-10-16(7-8-24-15)28-17-12-20(3,4)29-21(5,6)13-17/h7-8,10,14,17-18,27H,9,11-13,23H2,1-6H3,(H,25,26)/t18-,22+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM271229
PNG
(US10059720, Example 44)
Show SMILES N[C@@H](c1ccc(cc1)-c1cccnc1)[C@](O)(Cc1cc(OC2CCCCC2)ccn1)C(O)=O
Show InChI InChI=1S/C26H29N3O4/c27-24(19-10-8-18(9-11-19)20-5-4-13-28-17-20)26(32,25(30)31)16-21-15-23(12-14-29-21)33-22-6-2-1-3-7-22/h4-5,8-15,17,22,24,32H,1-3,6-7,16,27H2,(H,30,31)/t24-,26+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM271210
PNG
(US10059720, Example 25)
Show SMILES CCCCCCn1ccc2cnc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)cc12
Show InChI InChI=1S/C21H33N3O3/c1-4-5-6-7-9-24-10-8-16-14-23-17(12-18(16)24)13-21(27,20(25)26)19(22)11-15(2)3/h8,10,12,14-15,19,27H,4-7,9,11,13,22H2,1-3H3,(H,25,26)/t19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM271252
PNG
(US10059720, Example 67)
Show SMILES N[C@@H](C=C1CCOCC1)[C@](O)(Cc1cc(OC2CCCCC2)ccn1)C(O)=O
Show InChI InChI=1S/C21H30N2O5/c22-19(12-15-7-10-27-11-8-15)21(26,20(24)25)14-16-13-18(6-9-23-16)28-17-4-2-1-3-5-17/h6,9,12-13,17,19,26H,1-5,7-8,10-11,14,22H2,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM271246
PNG
(US10059720, Example 61)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(O[C@H]2CC[C@]3(CCCO3)CC2)ccn1)C(O)=O
Show InChI InChI=1S/C22H34N2O5/c1-15(2)12-19(23)22(27,20(25)26)14-16-13-18(6-10-24-16)29-17-4-8-21(9-5-17)7-3-11-28-21/h6,10,13,15,17,19,27H,3-5,7-9,11-12,14,23H2,1-2H3,(H,25,26)/t17-,19-,21+,22+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM271290
PNG
(US10059720, Example 105)
Show SMILES CCSC[C@H](N)[C@](O)(Cc1cc(O[C@H]2CC[C@H](C)CC2)ccn1)C(O)=O
Show InChI InChI=1S/C19H30N2O4S/c1-3-26-12-17(20)19(24,18(22)23)11-14-10-16(8-9-21-14)25-15-6-4-13(2)5-7-15/h8-10,13,15,17,24H,3-7,11-12,20H2,1-2H3,(H,22,23)/t13-,15-,17-,19+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM271211
PNG
(US10059720, Example 26)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(O[C@@H]2C[C@@H]3C[C@@H]3C2)ccn1)C(O)=O
Show InChI InChI=1S/C19H28N2O4/c1-11(2)5-17(20)19(24,18(22)23)10-14-9-15(3-4-21-14)25-16-7-12-6-13(12)8-16/h3-4,9,11-13,16-17,24H,5-8,10,20H2,1-2H3,(H,22,23)/t12-,13+,16+,17-,19+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM271241
PNG
(US10059720, Example 56)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(O[C@@H]2CC[C@H](C)CC2)ccn1)C(O)=O
Show InChI InChI=1S/C20H32N2O4/c1-13(2)10-18(21)20(25,19(23)24)12-15-11-17(8-9-22-15)26-16-6-4-14(3)5-7-16/h8-9,11,13-14,16,18,25H,4-7,10,12,21H2,1-3H3,(H,23,24)/t14-,16+,18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM271240
PNG
(US10059720, Example 55)
Show SMILES CCCC[C@@H](C)Oc1ccnc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)c1
Show InChI InChI=1S/C19H32N2O4/c1-5-6-7-14(4)25-16-8-9-21-15(11-16)12-19(24,18(22)23)17(20)10-13(2)3/h8-9,11,13-14,17,24H,5-7,10,12,20H2,1-4H3,(H,22,23)/t14-,17+,19-/m1/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM271260
PNG
(US10059720, Example 75)
Show SMILES COCCCCC[C@H](N)[C@](O)(Cc1cc(OC2CCCCC2)ccn1)C(O)=O
Show InChI InChI=1S/C21H34N2O5/c1-27-13-7-3-6-10-19(22)21(26,20(24)25)15-16-14-18(11-12-23-16)28-17-8-4-2-5-9-17/h11-12,14,17,19,26H,2-10,13,15,22H2,1H3,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM271251
PNG
(US10059720, Example 66)
Show SMILES CC(C)CC[C@H](N)[C@](O)(Cc1cc(OC2CCCCC2)ccn1)C(O)=O
Show InChI InChI=1S/C20H32N2O4/c1-14(2)8-9-18(21)20(25,19(23)24)13-15-12-17(10-11-22-15)26-16-6-4-3-5-7-16/h10-12,14,16,18,25H,3-9,13,21H2,1-2H3,(H,23,24)/t18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM271188
PNG
(US10059720, Example 4)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(OC2CCC3(CC3)CC2)ccn1)C(O)=O
Show InChI InChI=1S/C21H32N2O4/c1-14(2)11-18(22)21(26,19(24)25)13-15-12-17(5-10-23-15)27-16-3-6-20(7-4-16)8-9-20/h5,10,12,14,16,18,26H,3-4,6-9,11,13,22H2,1-2H3,(H,24,25)/t18-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM284929
PNG
(US10023583, Example 2)
Show SMILES CSC[C@H](N)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O
Show InChI InChI=1S/C18H24N2O4S/c1-25-10-16(19)18(23,17(21)22)9-14-13-8-12(5-4-11-2-3-11)24-15(13)6-7-20-14/h6-8,11,16,23H,2-5,9-10,19H2,1H3,(H,21,22)/t16-,18+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM271187
PNG
(US10059720, Example 3)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(OC2CCCCC2)ccn1)C(O)=O
Show InChI InChI=1S/C19H30N2O4/c1-13(2)10-17(20)19(24,18(22)23)12-14-11-16(8-9-21-14)25-15-6-4-3-5-7-15/h8-9,11,13,15,17,24H,3-7,10,12,20H2,1-2H3,(H,22,23)/t17-,19+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM271262
PNG
(US10059720, Example 77)
Show SMILES Cc1ccc(OC[C@H](N)[C@](O)(Cc2cc(OC3CCCCC3)ccn2)C(O)=O)nc1
Show InChI InChI=1S/C22H29N3O5/c1-15-7-8-20(25-13-15)29-14-19(23)22(28,21(26)27)12-16-11-18(9-10-24-16)30-17-5-3-2-4-6-17/h7-11,13,17,19,28H,2-6,12,14,23H2,1H3,(H,26,27)/t19-,22+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM271221
PNG
(US10059720, Example 36)
Show SMILES N[C@@H](c1ccc(cc1)-c1ccccc1)[C@](O)(Cc1cc(OC2CCCCC2)ccn1)C(O)=O
Show InChI InChI=1S/C27H30N2O4/c28-25(21-13-11-20(12-14-21)19-7-3-1-4-8-19)27(32,26(30)31)18-22-17-24(15-16-29-22)33-23-9-5-2-6-10-23/h1,3-4,7-8,11-17,23,25,32H,2,5-6,9-10,18,28H2,(H,30,31)/t25-,27+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM271215
PNG
(US10059720, Example 30)
Show SMILES COCc1ccc(OC[C@H](N)[C@](O)(Cc2cc(OC3CCCCC3)ccn2)C(O)=O)cc1
Show InChI InChI=1S/C24H32N2O6/c1-30-15-17-7-9-19(10-8-17)31-16-22(25)24(29,23(27)28)14-18-13-21(11-12-26-18)32-20-5-3-2-4-6-20/h7-13,20,22,29H,2-6,14-16,25H2,1H3,(H,27,28)/t22-,24+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM271228
PNG
(US10059720, Example 43)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(OC2C3CC4CC(C3)CC2C4)ccn1)C(O)=O
Show InChI InChI=1S/C23H34N2O4/c1-13(2)5-20(24)23(28,22(26)27)12-18-11-19(3-4-25-18)29-21-16-7-14-6-15(9-16)10-17(21)8-14/h3-4,11,13-17,20-21,28H,5-10,12,24H2,1-2H3,(H,26,27)/t14?,15?,16?,17?,20-,21?,23+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM271309
PNG
(US10059720, Example 124)
Show SMILES C[C@H]1CC[C@@H](CC1)Oc1ccnc(C[C@@](O)([C@@H](N)CC(C)(C)C)C(O)=O)c1
Show InChI InChI=1S/C21H34N2O4/c1-14-5-7-16(8-6-14)27-17-9-10-23-15(11-17)12-21(26,19(24)25)18(22)13-20(2,3)4/h9-11,14,16,18,26H,5-8,12-13,22H2,1-4H3,(H,24,25)/t14-,16-,18-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM271213
PNG
(US10059720, Example 28)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(OCCC2(C)CC2)ccn1)C(O)=O
Show InChI InChI=1S/C19H30N2O4/c1-13(2)10-16(20)19(24,17(22)23)12-14-11-15(4-8-21-14)25-9-7-18(3)5-6-18/h4,8,11,13,16,24H,5-7,9-10,12,20H2,1-3H3,(H,22,23)/t16-,19+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM271234
PNG
(US10059720, Example 49)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(OC2Cc3ccccc3C2)ccn1)C(O)=O
Show InChI InChI=1S/C22H28N2O4/c1-14(2)9-20(23)22(27,21(25)26)13-17-12-18(7-8-24-17)28-19-10-15-5-3-4-6-16(15)11-19/h3-8,12,14,19-20,27H,9-11,13,23H2,1-2H3,(H,25,26)/t20-,22+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM271243
PNG
(US10059720, Example 58)
Show SMILES CC(C)C[C@@H](C)Oc1ccnc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)c1
Show InChI InChI=1S/C19H32N2O4/c1-12(2)8-14(5)25-16-6-7-21-15(10-16)11-19(24,18(22)23)17(20)9-13(3)4/h6-7,10,12-14,17,24H,8-9,11,20H2,1-5H3,(H,22,23)/t14-,17+,19-/m1/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM271282
PNG
(US10059720, Example 97)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(OCCOC2CCCCC2)ccn1)C(O)=O
Show InChI InChI=1S/C21H34N2O5/c1-15(2)12-19(22)21(26,20(24)25)14-16-13-18(8-9-23-16)28-11-10-27-17-6-4-3-5-7-17/h8-9,13,15,17,19,26H,3-7,10-12,14,22H2,1-2H3,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM271225
PNG
(US10059720, Example 40)
Show SMILES N[C@@H](\C=C\c1ccccc1)[C@](O)(Cc1cc(OC2CCCCC2)ccn1)C(O)=O
Show InChI InChI=1S/C23H28N2O4/c24-21(12-11-17-7-3-1-4-8-17)23(28,22(26)27)16-18-15-20(13-14-25-18)29-19-9-5-2-6-10-19/h1,3-4,7-8,11-15,19,21,28H,2,5-6,9-10,16,24H2,(H,26,27)/b12-11+/t21-,23+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM271285
PNG
(US10059720, Example 100)
Show SMILES CCCCCCOc1ccnc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)c1
Show InChI InChI=1S/C19H32N2O4/c1-4-5-6-7-10-25-16-8-9-21-15(12-16)13-19(24,18(22)23)17(20)11-14(2)3/h8-9,12,14,17,24H,4-7,10-11,13,20H2,1-3H3,(H,22,23)/t17-,19+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM271199
PNG
(US10059720, Example 14)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(OCc2cccc3ccccc23)ccn1)C(O)=O
Show InChI InChI=1S/C24H28N2O4/c1-16(2)12-22(25)24(29,23(27)28)14-19-13-20(10-11-26-19)30-15-18-8-5-7-17-6-3-4-9-21(17)18/h3-11,13,16,22,29H,12,14-15,25H2,1-2H3,(H,27,28)/t22-,24+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM284954
PNG
(US10023583, Example 26)
Show SMILES CCCCc1cc2c(C[C@@](O)([C@@H](N)CSC)C(O)=O)ncc(C)c2o1
Show InChI InChI=1S/C18H26N2O4S/c1-4-5-6-12-7-13-14(20-9-11(2)16(13)24-12)8-18(23,17(21)22)15(19)10-25-3/h7,9,15,23H,4-6,8,10,19H2,1-3H3,(H,21,22)/t15-,18+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM271184
PNG
(US10059720, Example 1)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(OCCC2CC2)ccn1)C(O)=O
Show InChI InChI=1S/C18H28N2O4/c1-12(2)9-16(19)18(23,17(21)22)11-14-10-15(5-7-20-14)24-8-6-13-3-4-13/h5,7,10,12-13,16,23H,3-4,6,8-9,11,19H2,1-2H3,(H,21,22)/t16-,18+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM271283
PNG
(US10059720, Example 98)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(OCCOCc2ccccc2)ccn1)C(O)=O
Show InChI InChI=1S/C22H30N2O5/c1-16(2)12-20(23)22(27,21(25)26)14-18-13-19(8-9-24-18)29-11-10-28-15-17-6-4-3-5-7-17/h3-9,13,16,20,27H,10-12,14-15,23H2,1-2H3,(H,25,26)/t20-,22+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM284928
PNG
(US10023583, Example 1)
Show SMILES CCSC[C@H](N)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O
Show InChI InChI=1S/C19H26N2O4S/c1-2-26-11-17(20)19(24,18(22)23)10-15-14-9-13(6-5-12-3-4-12)25-16(14)7-8-21-15/h7-9,12,17,24H,2-6,10-11,20H2,1H3,(H,22,23)/t17-,19+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM271267
PNG
(US10059720, Example 82)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(O[C@H](C)CC2CC2)ccn1)C(O)=O
Show InChI InChI=1S/C19H30N2O4/c1-12(2)8-17(20)19(24,18(22)23)11-15-10-16(6-7-21-15)25-13(3)9-14-4-5-14/h6-7,10,12-14,17,24H,4-5,8-9,11,20H2,1-3H3,(H,22,23)/t13-,17+,19-/m1/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM284939
PNG
(US10023583, Example 11)
Show SMILES N[C@@H](CSCC1CCC1)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O
Show InChI InChI=1S/C22H30N2O4S/c23-20(13-29-12-15-2-1-3-15)22(27,21(25)26)11-18-17-10-16(7-6-14-4-5-14)28-19(17)8-9-24-18/h8-10,14-15,20,27H,1-7,11-13,23H2,(H,25,26)/t20-,22+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM271269
PNG
(US10059720, Example 84)
Show SMILES C[C@H]1CC[C@@H](CC1)Oc1ccnc(C[C@@](O)([C@@H](N)COc2ccc(F)cn2)C(O)=O)c1
Show InChI InChI=1S/C22H28FN3O5/c1-14-2-5-17(6-3-14)31-18-8-9-25-16(10-18)11-22(29,21(27)28)19(24)13-30-20-7-4-15(23)12-26-20/h4,7-10,12,14,17,19,29H,2-3,5-6,11,13,24H2,1H3,(H,27,28)/t14-,17-,19-,22+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM271266
PNG
(US10059720, Example 81)
Show SMILES C[C@H]1CC[C@@H](CC1)Oc1ccnc(C[C@@](O)([C@@H](N)COc2cnn(C)c2)C(O)=O)c1
Show InChI InChI=1S/C21H30N4O5/c1-14-3-5-16(6-4-14)30-17-7-8-23-15(9-17)10-21(28,20(26)27)19(22)13-29-18-11-24-25(2)12-18/h7-9,11-12,14,16,19,28H,3-6,10,13,22H2,1-2H3,(H,26,27)/t14-,16-,19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM271227
PNG
(US10059720, Example 42)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(OC2CCC(F)(F)CC2)ccn1)C(O)=O
Show InChI InChI=1S/C19H28F2N2O4/c1-12(2)9-16(22)19(26,17(24)25)11-13-10-15(5-8-23-13)27-14-3-6-18(20,21)7-4-14/h5,8,10,12,14,16,26H,3-4,6-7,9,11,22H2,1-2H3,(H,24,25)/t16-,19+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM284942
PNG
(US10023583, Example 14)
Show SMILES N[C@@H](CCC1CCC1)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O
Show InChI InChI=1S/C22H30N2O4/c23-20(9-7-14-2-1-3-14)22(27,21(25)26)13-18-17-12-16(8-6-15-4-5-15)28-19(17)10-11-24-18/h10-12,14-15,20,27H,1-9,13,23H2,(H,25,26)/t20-,22+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10023583 (2018)

More data for this
Ligand-Target Pair
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