BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 953 hits Enz. Inhib. hit(s) with Target = 'Leukotriene A-4 hydrolase'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50402386
PNG
(CHEMBL2207747)
Show SMILES CC(=O)NC1CC2CCC(C1)N2CCc1ccc(Oc2nc3ncccc3s2)cc1
Show InChI InChI=1S/C23H26N4O2S/c1-15(28)25-17-13-18-6-7-19(14-17)27(18)12-10-16-4-8-20(9-5-16)29-23-26-22-21(30-23)3-2-11-24-22/h2-5,8-9,11,17-19H,6-7,10,12-14H2,1H3,(H,25,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.300n/an/an/an/an/an/a



Janssen Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM217341
PNG
(US9303018, 14)
Show SMILES CCC(=O)N1CCN(Cc2cnc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)CC1
Show InChI InChI=1S/C25H26N6O2/c1-2-25(32)31-11-9-30(10-12-31)17-18-13-19-3-5-21(14-23(19)26-15-18)33-24-6-4-20(16-27-24)22-7-8-28-29-22/h3-8,13-16H,2,9-12,17H2,1H3,(H,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 0.440n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9303018 (2016)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50116537
PNG
(3-({3-[4-(Biphenyl-4-yloxy)-phenoxy]-propyl}-methy...)
Show SMILES CN(CCCOc1ccc(Oc2ccc(cc2)-c2ccccc2)cc1)CCC(O)=O
Show InChI InChI=1S/C25H27NO4/c1-26(18-16-25(27)28)17-5-19-29-22-12-14-24(15-13-22)30-23-10-8-21(9-11-23)20-6-3-2-4-7-20/h2-4,6-15H,5,16-19H2,1H3,(H,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

AffyNet 
PubMed
n/an/a<0.5n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human whole blood LTB-4 production (Leukotriene B-4).


J Med Chem 45: 3482-90 (2002)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50116537
PNG
(3-({3-[4-(Biphenyl-4-yloxy)-phenoxy]-propyl}-methy...)
Show SMILES CN(CCCOc1ccc(Oc2ccc(cc2)-c2ccccc2)cc1)CCC(O)=O
Show InChI InChI=1S/C25H27NO4/c1-26(18-16-25(27)28)17-5-19-29-22-12-14-24(15-13-22)30-23-10-8-21(9-11-23)20-6-3-2-4-7-20/h2-4,6-15H,5,16-19H2,1H3,(H,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

AffyNet 
Article
PubMed
n/an/a 0.5n/an/an/an/an/an/a



Gyeongsang National University (GNU)

Curated by ChEMBL


Assay Description
Inhibition of human leukotriene A4 hydrolase


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM217350
PNG
(US9303018, 23)
Show SMILES CC(C)C(=O)N1CCN(Cc2cnc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)CC1
Show InChI InChI=1S/C26H28N6O2/c1-18(2)26(33)32-11-9-31(10-12-32)17-19-13-20-3-5-22(14-24(20)27-15-19)34-25-6-4-21(16-28-25)23-7-8-29-30-23/h3-8,13-16,18H,9-12,17H2,1-2H3,(H,29,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 0.540n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9303018 (2016)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM217329
PNG
(US9303018, 2)
Show SMILES CC(=O)N1CCN(Cc2cnc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)CC1
Show InChI InChI=1S/C24H24N6O2/c1-17(31)30-10-8-29(9-11-30)16-18-12-19-2-4-21(13-23(19)25-14-18)32-24-5-3-20(15-26-24)22-6-7-27-28-22/h2-7,12-15H,8-11,16H2,1H3,(H,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 0.600n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9303018 (2016)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM217328
PNG
(US9303018, 1)
Show SMILES OCC(=O)N1CCN(Cc2cnc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)CC1
Show InChI InChI=1S/C24H24N6O3/c31-16-24(32)30-9-7-29(8-10-30)15-17-11-18-1-3-20(12-22(18)25-13-17)33-23-4-2-19(14-26-23)21-5-6-27-28-21/h1-6,11-14,31H,7-10,15-16H2,(H,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 0.690n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9303018 (2016)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50125433
PNG
(1-[2-(4-Benzyl-phenoxy)-ethyl]-1H-imidazo[4,5-b]py...)
Show SMILES N#Cc1ccc2n(CCOc3ccc(Cc4ccccc4)cc3)cnc2n1
Show InChI InChI=1S/C22H18N4O/c23-15-19-8-11-21-22(25-19)24-16-26(21)12-13-27-20-9-6-18(7-10-20)14-17-4-2-1-3-5-17/h1-11,16H,12-14H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 0.800n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibition of recombinant human leukotriene A4 hydrolase.


Bioorg Med Chem Lett 13: 1137-9 (2003)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM217336
PNG
(US9303018, 9)
Show SMILES CN(Cc1cnc2cc(Oc3ccc(cn3)-c3ccn[nH]3)ccc2c1)[C@@H]1CCN(C1)C(=O)CO
Show InChI InChI=1/C25H26N6O3/c1-30(20-7-9-31(15-20)25(33)16-32)14-17-10-18-2-4-21(11-23(18)26-12-17)34-24-5-3-19(13-27-24)22-6-8-28-29-22/h2-6,8,10-13,20,32H,7,9,14-16H2,1H3,(H,28,29)/t20-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 0.880n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9303018 (2016)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM217349
PNG
(US9303018, 22)
Show SMILES O=C(C1CC1)N1CCN(Cc2cnc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)CC1
Show InChI InChI=1S/C26H26N6O2/c33-26(19-1-2-19)32-11-9-31(10-12-32)17-18-13-20-3-5-22(14-24(20)27-15-18)34-25-6-4-21(16-28-25)23-7-8-29-30-23/h3-8,13-16,19H,1-2,9-12,17H2,(H,29,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 0.930n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9303018 (2016)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50251744
PNG
(CHEMBL481672 | endo-4-(2-(3-(4-(4-(oxazol-2-yl)phe...)
Show SMILES OC(=O)c1ccc(CCN2[C@H]3CC[C@@H]2C[C@@H](C3)Nc2ccc(Oc3ccc(cc3)-c3ncco3)cc2)cc1
Show InChI InChI=1S/C31H31N3O4/c35-31(36)23-3-1-21(2-4-23)15-17-34-26-9-10-27(34)20-25(19-26)33-24-7-13-29(14-8-24)38-28-11-5-22(6-12-28)30-32-16-18-37-30/h1-8,11-14,16,18,25-27,33H,9-10,15,17,19-20H2,(H,35,36)/t25-,26+,27-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50402382
PNG
(CHEMBL2207751)
Show SMILES CC(=O)NC1CC2CCC(C1)N2Cc1ccc(Oc2nc3ncccc3s2)cc1
Show InChI InChI=1S/C22H24N4O2S/c1-14(27)24-16-11-17-6-7-18(12-16)26(17)13-15-4-8-19(9-5-15)28-22-25-21-20(29-22)3-2-10-23-21/h2-5,8-10,16-18H,6-7,11-13H2,1H3,(H,24,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1n/an/an/an/an/an/a



Janssen Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50116563
PNG
(CHEMBL323686 | N-(3-{[3-(4-Benzyl-phenoxy)-propyl]...)
Show SMILES CN(CCCOc1ccc(Cc2ccccc2)cc1)CCC(=O)NS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C26H30N2O4S/c1-28(19-17-26(29)27-33(30,31)25-11-6-3-7-12-25)18-8-20-32-24-15-13-23(14-16-24)21-22-9-4-2-5-10-22/h2-7,9-16H,8,17-21H2,1H3,(H,27,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

AffyNet 
PubMed
n/an/a 1n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human leukotriene A4 hydrolase (LTA-4).


J Med Chem 45: 3482-90 (2002)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50317487
PNG
((S)-2-((4-(4-(thiophen-3-yl)phenoxy)phenoxy)methyl...)
Show SMILES C(Oc1ccc(Oc2ccc(cc2)-c2ccsc2)cc1)[C@@H]1CCCCN1
Show InChI InChI=1S/C22H23NO2S/c1-2-13-23-19(3-1)15-24-20-8-10-22(11-9-20)25-21-6-4-17(5-7-21)18-12-14-26-16-18/h4-12,14,16,19,23H,1-3,13,15H2/t19-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 1n/an/an/an/an/an/a



deCODE Chemistry, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human LTA4H hydrolysis assessed as inhibition of Ca2+ ionophore-stimulated LTB4 formation in human whole blood by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM217343
PNG
(US9303018, 16)
Show SMILES CN(CC1CN(C1)C(C)=O)Cc1cnc2cc(Oc3ccc(cn3)-c3ccn[nH]3)ccc2c1
Show InChI InChI=1S/C25H26N6O2/c1-17(32)31-15-19(16-31)14-30(2)13-18-9-20-3-5-22(10-24(20)26-11-18)33-25-6-4-21(12-27-25)23-7-8-28-29-23/h3-12,19H,13-16H2,1-2H3,(H,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 1.10n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9303018 (2016)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM217345
PNG
(US9303018, 18)
Show SMILES C[C@H](O)C(=O)N1CCN(Cc2cnc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)CC1
Show InChI InChI=1/C25H26N6O3/c1-17(32)25(33)31-10-8-30(9-11-31)16-18-12-19-2-4-21(13-23(19)26-14-18)34-24-5-3-20(15-27-24)22-6-7-28-29-22/h2-7,12-15,17,32H,8-11,16H2,1H3,(H,28,29)/t17-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 1.10n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9303018 (2016)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50116562
PNG
(CHEMBL117549 | [4-(4-Benzyl-phenoxy)-butylamino]-a...)
Show SMILES OC(=O)CNCCCCOc1ccc(Cc2ccccc2)cc1
Show InChI InChI=1S/C19H23NO3/c21-19(22)15-20-12-4-5-13-23-18-10-8-17(9-11-18)14-16-6-2-1-3-7-16/h1-3,6-11,20H,4-5,12-15H2,(H,21,22)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 1.30n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human leukotriene A4 hydrolase (LTA-4).


J Med Chem 45: 3482-90 (2002)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM217337
PNG
(US9303018, 10)
Show SMILES CN(Cc1cnc2cc(Oc3ccc(cn3)-c3ccn[nH]3)ccc2c1)[C@H]1CCN(C1)C(=O)CO
Show InChI InChI=1/C25H26N6O3/c1-30(20-7-9-31(15-20)25(33)16-32)14-17-10-18-2-4-21(11-23(18)26-12-17)34-24-5-3-19(13-27-24)22-6-8-28-29-22/h2-6,8,10-13,20,32H,7,9,14-16H2,1H3,(H,28,29)/t20-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 1.30n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9303018 (2016)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50116554
PNG
(CHEMBL119683 | N-(3-{[3-(4-Benzyl-phenoxy)-propyl]...)
Show SMILES CN(CCCOc1ccc(Cc2ccccc2)cc1)CCC(=O)NS(C)(=O)=O
Show InChI InChI=1S/C21H28N2O4S/c1-23(15-13-21(24)22-28(2,25)26)14-6-16-27-20-11-9-19(10-12-20)17-18-7-4-3-5-8-18/h3-5,7-12H,6,13-17H2,1-2H3,(H,22,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

AffyNet 
PubMed
n/an/a 1.30n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human leukotriene A4 hydrolase (LTA-4).


J Med Chem 45: 3482-90 (2002)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM217331
PNG
(US9303018, 4)
Show SMILES COCC(=O)N1CCN(Cc2cnc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)CC1
Show InChI InChI=1S/C25H26N6O3/c1-33-17-25(32)31-10-8-30(9-11-31)16-18-12-19-2-4-21(13-23(19)26-14-18)34-24-5-3-20(15-27-24)22-6-7-28-29-22/h2-7,12-15H,8-11,16-17H2,1H3,(H,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 1.40n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9303018 (2016)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM217346
PNG
(US9303018, 19)
Show SMILES CN(C)C(=O)C1CCN(Cc2cnc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)CC1
Show InChI InChI=1S/C26H28N6O2/c1-31(2)26(33)19-8-11-32(12-9-19)17-18-13-20-3-5-22(14-24(20)27-15-18)34-25-6-4-21(16-28-25)23-7-10-29-30-23/h3-7,10,13-16,19H,8-9,11-12,17H2,1-2H3,(H,29,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 1.5n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9303018 (2016)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM217347
PNG
(US9303018, 20)
Show SMILES CC(C)(O)C(=O)N1CCN(Cc2cnc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)CC1
Show InChI InChI=1S/C26H28N6O3/c1-26(2,34)25(33)32-11-9-31(10-12-32)17-18-13-19-3-5-21(14-23(19)27-15-18)35-24-6-4-20(16-28-24)22-7-8-29-30-22/h3-8,13-16,34H,9-12,17H2,1-2H3,(H,29,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 1.60n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9303018 (2016)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50425166
PNG
(CHEMBL2313573)
Show SMILES CC(=O)N[C@@H]1C[C@@H]2CC[C@H](C1)N2Cc1coc2cc(Oc3nc4ncccc4s3)ccc12
Show InChI InChI=1S/C24H24N4O3S/c1-14(29)26-16-9-17-4-5-18(10-16)28(17)12-15-13-30-21-11-19(6-7-20(15)21)31-24-27-23-22(32-24)3-2-8-25-23/h2-3,6-8,11,13,16-18H,4-5,9-10,12H2,1H3,(H,26,29)/t16-,17+,18-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.60n/an/an/an/an/an/a



Janssen Research& Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of recombinant human LTA4H expressed in Sf9 cells using LTA4 as substrate incubated for 10 mins prior to substrate addition measured after...


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM217344
PNG
(US9303018, 17)
Show SMILES O[C@@H]1CCN(Cc2cnc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)C1
Show InChI InChI=1/C22H21N5O2/c28-18-6-8-27(14-18)13-15-9-16-1-3-19(10-21(16)23-11-15)29-22-4-2-17(12-24-22)20-5-7-25-26-20/h1-5,7,9-12,18,28H,6,8,13-14H2,(H,25,26)/t18-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 1.70n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9303018 (2016)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM217348
PNG
(US9303018, 21)
Show SMILES CC(C)(C)C(=O)N1CCN(Cc2cnc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)CC1
Show InChI InChI=1S/C27H30N6O2/c1-27(2,3)26(34)33-12-10-32(11-13-33)18-19-14-20-4-6-22(15-24(20)28-16-19)35-25-7-5-21(17-29-25)23-8-9-30-31-23/h4-9,14-17H,10-13,18H2,1-3H3,(H,30,31)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 1.70n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9303018 (2016)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM217339
PNG
(US9303018, 12)
Show SMILES CN([C@@H]1CCN(Cc2cnc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)C1)C(=O)CO
Show InChI InChI=1/C25H26N6O3/c1-30(25(33)16-32)20-7-9-31(15-20)14-17-10-18-2-4-21(11-23(18)26-12-17)34-24-5-3-19(13-27-24)22-6-8-28-29-22/h2-6,8,10-13,20,32H,7,9,14-16H2,1H3,(H,28,29)/t20-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 1.80n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9303018 (2016)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM217333
PNG
(US9303018, 6)
Show SMILES O=C1OCCN1C1CCN(Cc2cnc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)CC1
Show InChI InChI=1S/C26H26N6O3/c33-26-32(11-12-34-26)21-6-9-31(10-7-21)17-18-13-19-1-3-22(14-24(19)27-15-18)35-25-4-2-20(16-28-25)23-5-8-29-30-23/h1-5,8,13-16,21H,6-7,9-12,17H2,(H,29,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 1.90n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9303018 (2016)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50251705
PNG
(4-(2-(3-(4-(4-(oxazol-2-yl)phenoxy)phenylamino)pip...)
Show SMILES OC(=O)c1ccc(CCN2CCCC(C2)Nc2ccc(Oc3ccc(cc3)-c3ncco3)cc2)cc1
Show InChI InChI=1S/C29H29N3O4/c33-29(34)23-5-3-21(4-6-23)15-18-32-17-1-2-25(20-32)31-24-9-13-27(14-10-24)36-26-11-7-22(8-12-26)28-30-16-19-35-28/h3-14,16,19,25,31H,1-2,15,17-18,20H2,(H,33,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 2n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50116560
PNG
(3-{Methyl-[3-(4-thiophen-3-ylmethyl-phenoxy)-propy...)
Show SMILES CN(CCCOc1ccc(Cc2ccsc2)cc1)CCC(O)=O
Show InChI InChI=1S/C18H23NO3S/c1-19(10-7-18(20)21)9-2-11-22-17-5-3-15(4-6-17)13-16-8-12-23-14-16/h3-6,8,12,14H,2,7,9-11,13H2,1H3,(H,20,21)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
PubMed
n/an/a 2n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human leukotriene A4 hydrolase (LTA-4).


J Med Chem 45: 3482-90 (2002)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50116560
PNG
(3-{Methyl-[3-(4-thiophen-3-ylmethyl-phenoxy)-propy...)
Show SMILES CN(CCCOc1ccc(Cc2ccsc2)cc1)CCC(O)=O
Show InChI InChI=1S/C18H23NO3S/c1-19(10-7-18(20)21)9-2-11-22-17-5-3-15(4-6-17)13-16-8-12-23-14-16/h3-6,8,12,14H,2,7,9-11,13H2,1H3,(H,20,21)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 2n/an/an/an/an/an/a



Gyeongsang National University (GNU)

Curated by ChEMBL


Assay Description
Inhibition of human leukotriene A4 hydrolase


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM217335
PNG
(US9303018, 8)
Show SMILES CC1(O)CN(Cc2cnc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)C1
Show InChI InChI=1S/C22H21N5O2/c1-22(28)13-27(14-22)12-15-8-16-2-4-18(9-20(16)23-10-15)29-21-5-3-17(11-24-21)19-6-7-25-26-19/h2-11,28H,12-14H2,1H3,(H,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 2.40n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9303018 (2016)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM217340
PNG
(US9303018, 13)
Show SMILES O[C@H]1CCN(Cc2cnc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)C1
Show InChI InChI=1/C22H21N5O2/c28-18-6-8-27(14-18)13-15-9-16-1-3-19(10-21(16)23-11-15)29-22-4-2-17(12-24-22)20-5-7-25-26-20/h1-5,7,9-12,18,28H,6,8,13-14H2,(H,25,26)/t18-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 2.5n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9303018 (2016)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50116538
PNG
(3-{[3-(4-Benzyl-phenoxy)-propyl]-methyl-amino}-pro...)
Show SMILES CN(CCCOc1ccc(Cc2ccccc2)cc1)CCC(O)=O
Show InChI InChI=1S/C20H25NO3/c1-21(14-12-20(22)23)13-5-15-24-19-10-8-18(9-11-19)16-17-6-3-2-4-7-17/h2-4,6-11H,5,12-16H2,1H3,(H,22,23)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
PDB
UniChem

Similars

AffyNet 
PDB
PubMed
n/an/a 2.5n/an/an/an/an/an/a



Pharmacia Corporation

Curated by ChEMBL


Assay Description
Inhibition of leukotriene A4 hydrolase in human recombinant assay


Bioorg Med Chem Lett 12: 3383-6 (2002)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50116538
PNG
(3-{[3-(4-Benzyl-phenoxy)-propyl]-methyl-amino}-pro...)
Show SMILES CN(CCCOc1ccc(Cc2ccccc2)cc1)CCC(O)=O
Show InChI InChI=1S/C20H25NO3/c1-21(14-12-20(22)23)13-5-15-24-19-10-8-18(9-11-19)16-17-6-3-2-4-7-17/h2-4,6-11H,5,12-16H2,1H3,(H,22,23)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
PDB
UniChem

Similars

AffyNet 
PDB
PubMed
n/an/a 2.5n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human leukotriene A4 hydrolase (LTA-4).


J Med Chem 45: 3482-90 (2002)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM217338
PNG
(US9303018, 11)
Show SMILES CN([C@H]1CCN(Cc2cnc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)C1)C(=O)CO
Show InChI InChI=1/C25H26N6O3/c1-30(25(33)16-32)20-7-9-31(15-20)14-17-10-18-2-4-21(11-23(18)26-12-17)34-24-5-3-19(13-27-24)22-6-8-28-29-22/h2-6,8,10-13,20,32H,7,9,14-16H2,1H3,(H,28,29)/t20-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 2.60n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9303018 (2016)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM217332
PNG
(US9303018, 5)
Show SMILES O[C@H]1CCN(C2CCN(Cc3cnc4cc(Oc5ccc(cn5)-c5ccn[nH]5)ccc4c3)CC2)C1=O
Show InChI InChI=1/C27H28N6O3/c34-25-8-12-33(27(25)35)21-6-10-32(11-7-21)17-18-13-19-1-3-22(14-24(19)28-15-18)36-26-4-2-20(16-29-26)23-5-9-30-31-23/h1-5,9,13-16,21,25,34H,6-8,10-12,17H2,(H,30,31)/t25-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 2.60n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9303018 (2016)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50402403
PNG
(CHEMBL2207730)
Show SMILES C(N1CCCCC1)c1ccc(Oc2nc3ncccc3s2)cc1
Show InChI InChI=1S/C18H19N3OS/c1-2-11-21(12-3-1)13-14-6-8-15(9-7-14)22-18-20-17-16(23-18)5-4-10-19-17/h4-10H,1-3,11-13H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 3n/an/an/an/an/an/a



Janssen Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50251448
PNG
(4-(((3-((2-(4-benzylphenylamino)-2-oxoethyl)(methy...)
Show SMILES CN(CCCN(C)Cc1ccc(cc1)C(O)=O)CC(=O)Nc1ccc(Cc2ccccc2)cc1
Show InChI InChI=1S/C28H33N3O3/c1-30(20-24-9-13-25(14-10-24)28(33)34)17-6-18-31(2)21-27(32)29-26-15-11-23(12-16-26)19-22-7-4-3-5-8-22/h3-5,7-16H,6,17-21H2,1-2H3,(H,29,32)(H,33,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 3n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase (unknown origin) by hydrolase assay


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50251386
PNG
(4-(2-(methyl(3-(methyl(2-oxo-2-(4-phenoxyphenylami...)
Show SMILES CN(CCCN(C)CC(=O)Nc1ccc(Oc2ccccc2)cc1)CCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C28H33N3O4/c1-30(20-17-22-9-11-23(12-10-22)28(33)34)18-6-19-31(2)21-27(32)29-24-13-15-26(16-14-24)35-25-7-4-3-5-8-25/h3-5,7-16H,6,17-21H2,1-2H3,(H,29,32)(H,33,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 3n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase (unknown origin) by hydrolase assay


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50285632
PNG
((S)-2-[((R)-2-Benzyl-3-hydroxycarbamoyl-propionyl)...)
Show SMILES C[C@H](N(C)C(=O)[C@@H](CC(=O)NO)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C15H20N2O5/c1-10(15(20)21)17(2)14(19)12(9-13(18)16-22)8-11-6-4-3-5-7-11/h3-7,10,12,22H,8-9H2,1-2H3,(H,16,18)(H,20,21)/t10-,12+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
n/an/a 3n/an/an/an/an/an/a


TBA

Assay Description
Inhibitory activity against recombinant human Leukotriene A4 hydrolase


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50425168
PNG
(CHEMBL2313571)
Show SMILES O=C1CCCN1C1CCN(Cc2coc3cc(Oc4nc5ncccc5s4)ccc23)CC1
Show InChI InChI=1S/C24H24N4O3S/c29-22-4-2-10-28(22)17-7-11-27(12-8-17)14-16-15-30-20-13-18(5-6-19(16)20)31-24-26-23-21(32-24)3-1-9-25-23/h1,3,5-6,9,13,15,17H,2,4,7-8,10-12,14H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 3n/an/an/an/an/an/a



Janssen Research& Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of recombinant human LTA4H expressed in Sf9 cells using LTA4 as substrate incubated for 10 mins prior to substrate addition measured after...


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50402384
PNG
(CHEMBL2207749)
Show SMILES CC(=O)N1CC2CN(Cc3ccc(Oc4nc5ncccc5s4)cc3)CC2C1
Show InChI InChI=1S/C21H22N4O2S/c1-14(26)25-12-16-10-24(11-17(16)13-25)9-15-4-6-18(7-5-15)27-21-23-20-19(28-21)3-2-8-22-20/h2-8,16-17H,9-13H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 3n/an/an/an/an/an/a



Janssen Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50402391
PNG
(CHEMBL2207742)
Show SMILES C(Cc1ccc(Oc2nc3ncccc3s2)cc1)N1CCCCC1
Show InChI InChI=1S/C19H21N3OS/c1-2-12-22(13-3-1)14-10-15-6-8-16(9-7-15)23-19-21-18-17(24-19)5-4-11-20-18/h4-9,11H,1-3,10,12-14H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 3n/an/an/an/an/an/a



Janssen Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50251397
PNG
(CHEMBL480334 | endo-4-((3-(4-benzylphenylamino)-8-...)
Show SMILES OC(=O)c1ccc(CN2[C@H]3CC[C@@H]2C[C@@H](C3)Nc2ccc(Cc3ccccc3)cc2)cc1
Show InChI InChI=1S/C28H30N2O2/c31-28(32)23-10-6-22(7-11-23)19-30-26-14-15-27(30)18-25(17-26)29-24-12-8-21(9-13-24)16-20-4-2-1-3-5-20/h1-13,25-27,29H,14-19H2,(H,31,32)/t25-,26+,27-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 3n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50251665
PNG
(4-(2-(4-(4-(4-(oxazol-2-yl)phenoxy)phenylamino)pip...)
Show SMILES OC(=O)c1ccc(CCN2CCC(CC2)Nc2ccc(Oc3ccc(cc3)-c3ncco3)cc2)cc1
Show InChI InChI=1S/C29H29N3O4/c33-29(34)23-3-1-21(2-4-23)13-17-32-18-14-25(15-19-32)31-24-7-11-27(12-8-24)36-26-9-5-22(6-10-26)28-30-16-20-35-28/h1-12,16,20,25,31H,13-15,17-19H2,(H,33,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 3n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50251627
PNG
(4-((methyl(3-(4-(4-(oxazol-2-yl)phenoxy)phenylamin...)
Show SMILES CN(CCCNc1ccc(Oc2ccc(cc2)-c2ncco2)cc1)Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C27H27N3O4/c1-30(19-20-3-5-22(6-4-20)27(31)32)17-2-15-28-23-9-13-25(14-10-23)34-24-11-7-21(8-12-24)26-29-16-18-33-26/h3-14,16,18,28H,2,15,17,19H2,1H3,(H,31,32)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 3n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM217342
PNG
(US9303018, 15)
Show SMILES CN(C1CCN(Cc2cnc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)CC1)C(=O)CO
Show InChI InChI=1S/C26H28N6O3/c1-31(26(34)17-33)21-7-10-32(11-8-21)16-18-12-19-2-4-22(13-24(19)27-14-18)35-25-5-3-20(15-28-25)23-6-9-29-30-23/h2-6,9,12-15,21,33H,7-8,10-11,16-17H2,1H3,(H,29,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 3.5n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9303018 (2016)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50425170
PNG
(CHEMBL2313569)
Show SMILES CC(=O)NC1CCN(Cc2coc3cc(Oc4nc5ncccc5s4)ccc23)CC1
Show InChI InChI=1S/C22H22N4O3S/c1-14(27)24-16-6-9-26(10-7-16)12-15-13-28-19-11-17(4-5-18(15)19)29-22-25-21-20(30-22)3-2-8-23-21/h2-5,8,11,13,16H,6-7,9-10,12H2,1H3,(H,24,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 3.70n/an/an/an/an/an/a



Janssen Research& Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of recombinant human LTA4H expressed in Sf9 cells using LTA4 as substrate incubated for 10 mins prior to substrate addition measured after...


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM217334
PNG
(US9303018, 7)
Show SMILES OC1CCN(Cc2cnc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)CC1
Show InChI InChI=1S/C23H23N5O2/c29-19-6-9-28(10-7-19)15-16-11-17-1-3-20(12-22(17)24-13-16)30-23-4-2-18(14-25-23)21-5-8-26-27-21/h1-5,8,11-14,19,29H,6-7,9-10,15H2,(H,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 3.70n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9303018 (2016)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50303656
PNG
((R)-2-[4-(4-Thiophen-3-yl-benzyl)phenoxymethyl]pyr...)
Show SMILES C(Oc1ccc(Cc2ccc(cc2)-c2ccsc2)cc1)[C@H]1CCCN1
Show InChI InChI=1S/C22H23NOS/c1-2-21(23-12-1)15-24-22-9-5-18(6-10-22)14-17-3-7-19(8-4-17)20-11-13-25-16-20/h3-11,13,16,21,23H,1-2,12,14-15H2/t21-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 4n/an/an/an/an/an/a



deCODE Chemistry, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant LTA4H hydrolysis assessed as inhibition of LTB4 formation by LC-MS/MS


Citation and Details
Checked by Author
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 953 total )  |  Next  |  Last  >>
Jump to: