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Compile Data Set for Download or QSAR

Found 891 hits Enz. Inhib. hit(s) with Target = 'Leukotriene A4 hydrolase'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50402386
PNG
(CHEMBL2207747)
Show SMILES CC(=O)NC1CC2CCC(C1)N2CCc1ccc(Oc2nc3ncccc3s2)cc1
Show InChI InChI=1S/C23H26N4O2S/c1-15(28)25-17-13-18-6-7-19(14-17)27(18)12-10-16-4-8-20(9-5-16)29-23-26-22-21(30-23)3-2-11-24-22/h2-5,8-9,11,17-19H,6-7,10,12-14H2,1H3,(H,25,28)
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n/an/a 0.300n/an/an/an/an/an/a



Janssen Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50116537
PNG
(3-({3-[4-(Biphenyl-4-yloxy)-phenoxy]-propyl}-methy...)
Show SMILES CN(CCCOc1ccc(Oc2ccc(cc2)-c2ccccc2)cc1)CCC(O)=O
Show InChI InChI=1S/C25H27NO4/c1-26(18-16-25(27)28)17-5-19-29-22-12-14-24(15-13-22)30-23-10-8-21(9-11-23)20-6-3-2-4-7-20/h2-4,6-15H,5,16-19H2,1H3,(H,27,28)
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n/an/a<0.5n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human whole blood LTB-4 production (Leukotriene B-4).


J Med Chem 45: 3482-90 (2002)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50116537
PNG
(3-({3-[4-(Biphenyl-4-yloxy)-phenoxy]-propyl}-methy...)
Show SMILES CN(CCCOc1ccc(Oc2ccc(cc2)-c2ccccc2)cc1)CCC(O)=O
Show InChI InChI=1S/C25H27NO4/c1-26(18-16-25(27)28)17-5-19-29-22-12-14-24(15-13-22)30-23-10-8-21(9-11-23)20-6-3-2-4-7-20/h2-4,6-15H,5,16-19H2,1H3,(H,27,28)
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n/an/a 0.5n/an/an/an/an/an/a



Gyeongsang National University (GNU)

Curated by ChEMBL


Assay Description
Inhibition of human leukotriene A4 hydrolase


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50125433
PNG
(1-[2-(4-Benzyl-phenoxy)-ethyl]-1H-imidazo[4,5-b]py...)
Show SMILES N#Cc1ccc2n(CCOc3ccc(Cc4ccccc4)cc3)cnc2n1
Show InChI InChI=1S/C22H18N4O/c23-15-19-8-11-21-22(25-19)24-16-26(21)12-13-27-20-9-6-18(7-10-20)14-17-4-2-1-3-5-17/h1-11,16H,12-14H2
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n/an/a 0.800n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibition of recombinant human leukotriene A4 hydrolase.


Bioorg Med Chem Lett 13: 1137-9 (2003)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50251744
PNG
(CHEMBL481672 | endo-4-(2-(3-(4-(4-(oxazol-2-yl)phe...)
Show SMILES OC(=O)c1ccc(CCN2[C@H]3CC[C@@H]2C[C@@H](C3)Nc2ccc(Oc3ccc(cc3)-c3ncco3)cc2)cc1
Show InChI InChI=1S/C31H31N3O4/c35-31(36)23-3-1-21(2-4-23)15-17-34-26-9-10-27(34)20-25(19-26)33-24-7-13-29(14-8-24)38-28-11-5-22(6-12-28)30-32-16-18-37-30/h1-8,11-14,16,18,25-27,33H,9-10,15,17,19-20H2,(H,35,36)/t25-,26+,27-
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n/an/a 1n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50317487
PNG
((S)-2-((4-(4-(thiophen-3-yl)phenoxy)phenoxy)methyl...)
Show SMILES C(Oc1ccc(Oc2ccc(cc2)-c2ccsc2)cc1)[C@@H]1CCCCN1
Show InChI InChI=1S/C22H23NO2S/c1-2-13-23-19(3-1)15-24-20-8-10-22(11-9-20)25-21-6-4-17(5-7-21)18-12-14-26-16-18/h4-12,14,16,19,23H,1-3,13,15H2/t19-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



deCODE Chemistry, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human LTA4H hydrolysis assessed as inhibition of Ca2+ ionophore-stimulated LTB4 formation in human whole blood by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50116563
PNG
(CHEMBL323686 | N-(3-{[3-(4-Benzyl-phenoxy)-propyl]...)
Show SMILES CN(CCCOc1ccc(Cc2ccccc2)cc1)CCC(=O)NS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C26H30N2O4S/c1-28(19-17-26(29)27-33(30,31)25-11-6-3-7-12-25)18-8-20-32-24-15-13-23(14-16-24)21-22-9-4-2-5-10-22/h2-7,9-16H,8,17-21H2,1H3,(H,27,29)
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n/an/a 1n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human leukotriene A4 hydrolase (LTA-4).


J Med Chem 45: 3482-90 (2002)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50402382
PNG
(CHEMBL2207751)
Show SMILES CC(=O)NC1CC2CCC(C1)N2Cc1ccc(Oc2nc3ncccc3s2)cc1
Show InChI InChI=1S/C22H24N4O2S/c1-14(27)24-16-11-17-6-7-18(12-16)26(17)13-15-4-8-19(9-5-15)28-22-25-21-20(29-22)3-2-10-23-21/h2-5,8-10,16-18H,6-7,11-13H2,1H3,(H,24,27)
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n/an/a 1n/an/an/an/an/an/a



Janssen Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50116554
PNG
(CHEMBL119683 | N-(3-{[3-(4-Benzyl-phenoxy)-propyl]...)
Show SMILES CN(CCCOc1ccc(Cc2ccccc2)cc1)CCC(=O)NS(C)(=O)=O
Show InChI InChI=1S/C21H28N2O4S/c1-23(15-13-21(24)22-28(2,25)26)14-6-16-27-20-11-9-19(10-12-20)17-18-7-4-3-5-8-18/h3-5,7-12H,6,13-17H2,1-2H3,(H,22,24)
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n/an/a 1.30n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human leukotriene A4 hydrolase (LTA-4).


J Med Chem 45: 3482-90 (2002)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50116562
PNG
(CHEMBL117549 | [4-(4-Benzyl-phenoxy)-butylamino]-a...)
Show SMILES OC(=O)CNCCCCOc1ccc(Cc2ccccc2)cc1
Show InChI InChI=1S/C19H23NO3/c21-19(22)15-20-12-4-5-13-23-18-10-8-17(9-11-18)14-16-6-2-1-3-7-16/h1-3,6-11,20H,4-5,12-15H2,(H,21,22)
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n/an/a 1.30n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human leukotriene A4 hydrolase (LTA-4).


J Med Chem 45: 3482-90 (2002)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50425166
PNG
(CHEMBL2313573)
Show SMILES CC(=O)N[C@@H]1C[C@@H]2CC[C@H](C1)N2Cc1coc2cc(Oc3nc4ncccc4s3)ccc12
Show InChI InChI=1S/C24H24N4O3S/c1-14(29)26-16-9-17-4-5-18(10-16)28(17)12-15-13-30-21-11-19(6-7-20(15)21)31-24-27-23-22(32-24)3-2-8-25-23/h2-3,6-8,11,13,16-18H,4-5,9-10,12H2,1H3,(H,26,29)/t16-,17+,18-
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n/an/a 1.60n/an/an/an/an/an/a



Janssen Research& Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of recombinant human LTA4H expressed in Sf9 cells using LTA4 as substrate incubated for 10 mins prior to substrate addition measured after...


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50251705
PNG
(4-(2-(3-(4-(4-(oxazol-2-yl)phenoxy)phenylamino)pip...)
Show SMILES OC(=O)c1ccc(CCN2CCCC(C2)Nc2ccc(Oc3ccc(cc3)-c3ncco3)cc2)cc1
Show InChI InChI=1S/C29H29N3O4/c33-29(34)23-5-3-21(4-6-23)15-18-32-17-1-2-25(20-32)31-24-9-13-27(14-10-24)36-26-11-7-22(8-12-26)28-30-16-19-35-28/h3-14,16,19,25,31H,1-2,15,17-18,20H2,(H,33,34)
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n/an/a 2n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50116560
PNG
(3-{Methyl-[3-(4-thiophen-3-ylmethyl-phenoxy)-propy...)
Show SMILES CN(CCCOc1ccc(Cc2ccsc2)cc1)CCC(O)=O
Show InChI InChI=1S/C18H23NO3S/c1-19(10-7-18(20)21)9-2-11-22-17-5-3-15(4-6-17)13-16-8-12-23-14-16/h3-6,8,12,14H,2,7,9-11,13H2,1H3,(H,20,21)
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n/an/a 2n/an/an/an/an/an/a



Gyeongsang National University (GNU)

Curated by ChEMBL


Assay Description
Inhibition of human leukotriene A4 hydrolase


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50116560
PNG
(3-{Methyl-[3-(4-thiophen-3-ylmethyl-phenoxy)-propy...)
Show SMILES CN(CCCOc1ccc(Cc2ccsc2)cc1)CCC(O)=O
Show InChI InChI=1S/C18H23NO3S/c1-19(10-7-18(20)21)9-2-11-22-17-5-3-15(4-6-17)13-16-8-12-23-14-16/h3-6,8,12,14H,2,7,9-11,13H2,1H3,(H,20,21)
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n/an/a 2n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human leukotriene A4 hydrolase (LTA-4).


J Med Chem 45: 3482-90 (2002)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50116538
PNG
(3-{[3-(4-Benzyl-phenoxy)-propyl]-methyl-amino}-pro...)
Show SMILES CN(CCCOc1ccc(Cc2ccccc2)cc1)CCC(O)=O
Show InChI InChI=1S/C20H25NO3/c1-21(14-12-20(22)23)13-5-15-24-19-10-8-18(9-11-19)16-17-6-3-2-4-7-17/h2-4,6-11H,5,12-16H2,1H3,(H,22,23)
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n/an/a 2.5n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human leukotriene A4 hydrolase (LTA-4).


J Med Chem 45: 3482-90 (2002)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50116538
PNG
(3-{[3-(4-Benzyl-phenoxy)-propyl]-methyl-amino}-pro...)
Show SMILES CN(CCCOc1ccc(Cc2ccccc2)cc1)CCC(O)=O
Show InChI InChI=1S/C20H25NO3/c1-21(14-12-20(22)23)13-5-15-24-19-10-8-18(9-11-19)16-17-6-3-2-4-7-17/h2-4,6-11H,5,12-16H2,1H3,(H,22,23)
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n/an/a 2.5n/an/an/an/an/an/a



Pharmacia Corporation

Curated by ChEMBL


Assay Description
Inhibition of leukotriene A4 hydrolase in human recombinant assay


Bioorg Med Chem Lett 12: 3383-6 (2002)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50285632
PNG
((S)-2-[((R)-2-Benzyl-3-hydroxycarbamoyl-propionyl)...)
Show SMILES C[C@H](N(C)C(=O)[C@@H](CC(=O)NO)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C15H20N2O5/c1-10(15(20)21)17(2)14(19)12(9-13(18)16-22)8-11-6-4-3-5-7-11/h3-7,10,12,22H,8-9H2,1-2H3,(H,16,18)(H,20,21)/t10-,12+/m0/s1
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n/an/a 3n/an/an/an/an/an/a


TBA

Assay Description
Inhibitory activity against recombinant human Leukotriene A4 hydrolase


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50425168
PNG
(CHEMBL2313571)
Show SMILES O=C1CCCN1C1CCN(Cc2coc3cc(Oc4nc5ncccc5s4)ccc23)CC1
Show InChI InChI=1S/C24H24N4O3S/c29-22-4-2-10-28(22)17-7-11-27(12-8-17)14-16-15-30-20-13-18(5-6-19(16)20)31-24-26-23-21(32-24)3-1-9-25-23/h1,3,5-6,9,13,15,17H,2,4,7-8,10-12,14H2
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Janssen Research& Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of recombinant human LTA4H expressed in Sf9 cells using LTA4 as substrate incubated for 10 mins prior to substrate addition measured after...


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50402384
PNG
(CHEMBL2207749)
Show SMILES CC(=O)N1CC2CN(Cc3ccc(Oc4nc5ncccc5s4)cc3)CC2C1
Show InChI InChI=1S/C21H22N4O2S/c1-14(26)25-12-16-10-24(11-17(16)13-25)9-15-4-6-18(7-5-15)27-21-23-20-19(28-21)3-2-8-22-20/h2-8,16-17H,9-13H2,1H3
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Janssen Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50402391
PNG
(CHEMBL2207742)
Show SMILES C(Cc1ccc(Oc2nc3ncccc3s2)cc1)N1CCCCC1
Show InChI InChI=1S/C19H21N3OS/c1-2-12-22(13-3-1)14-10-15-6-8-16(9-7-15)23-19-21-18-17(24-19)5-4-11-20-18/h4-9,11H,1-3,10,12-14H2
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Janssen Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50251448
PNG
(4-(((3-((2-(4-benzylphenylamino)-2-oxoethyl)(methy...)
Show SMILES CN(CCCN(C)Cc1ccc(cc1)C(O)=O)CC(=O)Nc1ccc(Cc2ccccc2)cc1
Show InChI InChI=1S/C28H33N3O3/c1-30(20-24-9-13-25(14-10-24)28(33)34)17-6-18-31(2)21-27(32)29-26-15-11-23(12-16-26)19-22-7-4-3-5-8-22/h3-5,7-16H,6,17-21H2,1-2H3,(H,29,32)(H,33,34)
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n/an/a 3n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase (unknown origin) by hydrolase assay


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50251397
PNG
(CHEMBL480334 | endo-4-((3-(4-benzylphenylamino)-8-...)
Show SMILES OC(=O)c1ccc(CN2[C@H]3CC[C@@H]2C[C@@H](C3)Nc2ccc(Cc3ccccc3)cc2)cc1
Show InChI InChI=1S/C28H30N2O2/c31-28(32)23-10-6-22(7-11-23)19-30-26-14-15-27(30)18-25(17-26)29-24-12-8-21(9-13-24)16-20-4-2-1-3-5-20/h1-13,25-27,29H,14-19H2,(H,31,32)/t25-,26+,27-
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n/an/a 3n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50251665
PNG
(4-(2-(4-(4-(4-(oxazol-2-yl)phenoxy)phenylamino)pip...)
Show SMILES OC(=O)c1ccc(CCN2CCC(CC2)Nc2ccc(Oc3ccc(cc3)-c3ncco3)cc2)cc1
Show InChI InChI=1S/C29H29N3O4/c33-29(34)23-3-1-21(2-4-23)13-17-32-18-14-25(15-19-32)31-24-7-11-27(12-8-24)36-26-9-5-22(6-10-26)28-30-16-20-35-28/h1-12,16,20,25,31H,13-15,17-19H2,(H,33,34)
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Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50251627
PNG
(4-((methyl(3-(4-(4-(oxazol-2-yl)phenoxy)phenylamin...)
Show SMILES CN(CCCNc1ccc(Oc2ccc(cc2)-c2ncco2)cc1)Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C27H27N3O4/c1-30(19-20-3-5-22(6-4-20)27(31)32)17-2-15-28-23-9-13-25(14-10-23)34-24-11-7-21(8-12-24)26-29-16-18-33-26/h3-14,16,18,28H,2,15,17,19H2,1H3,(H,31,32)
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n/an/a 3n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50251386
PNG
(4-(2-(methyl(3-(methyl(2-oxo-2-(4-phenoxyphenylami...)
Show SMILES CN(CCCN(C)CC(=O)Nc1ccc(Oc2ccccc2)cc1)CCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C28H33N3O4/c1-30(20-17-22-9-11-23(12-10-22)28(33)34)18-6-19-31(2)21-27(32)29-24-13-15-26(16-14-24)35-25-7-4-3-5-8-25/h3-5,7-16H,6,17-21H2,1-2H3,(H,29,32)(H,33,34)
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n/an/a 3n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase (unknown origin) by hydrolase assay


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50402403
PNG
(CHEMBL2207730)
Show SMILES C(N1CCCCC1)c1ccc(Oc2nc3ncccc3s2)cc1
Show InChI InChI=1S/C18H19N3OS/c1-2-11-21(12-3-1)13-14-6-8-15(9-7-14)22-18-20-17-16(23-18)5-4-10-19-17/h4-10H,1-3,11-13H2
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Janssen Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50425170
PNG
(CHEMBL2313569)
Show SMILES CC(=O)NC1CCN(Cc2coc3cc(Oc4nc5ncccc5s4)ccc23)CC1
Show InChI InChI=1S/C22H22N4O3S/c1-14(27)24-16-6-9-26(10-7-16)12-15-13-28-19-11-17(4-5-18(15)19)29-22-25-21-20(30-22)3-2-8-23-21/h2-5,8,11,13,16H,6-7,9-10,12H2,1H3,(H,24,27)
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n/an/a 3.70n/an/an/an/an/an/a



Janssen Research& Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of recombinant human LTA4H expressed in Sf9 cells using LTA4 as substrate incubated for 10 mins prior to substrate addition measured after...


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50116544
PNG
(2-{[3-(4-Benzyl-phenoxy)-propyl]-methyl-amino}-eth...)
Show SMILES CN(CCCOc1ccc(Cc2ccccc2)cc1)CCS(N)(=O)=O
Show InChI InChI=1S/C19H26N2O3S/c1-21(13-15-25(20,22)23)12-5-14-24-19-10-8-18(9-11-19)16-17-6-3-2-4-7-17/h2-4,6-11H,5,12-16H2,1H3,(H2,20,22,23)
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n/an/a 4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human leukotriene A4 hydrolase (LTA-4).


J Med Chem 45: 3482-90 (2002)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50402392
PNG
(CHEMBL2207741)
Show SMILES CC(=O)NC1CC2CCC(C1)N2CCOc1ccc(Oc2nc3ncccc3s2)cc1
Show InChI InChI=1S/C23H26N4O3S/c1-15(28)25-16-13-17-4-5-18(14-16)27(17)11-12-29-19-6-8-20(9-7-19)30-23-26-22-21(31-23)3-2-10-24-22/h2-3,6-10,16-18H,4-5,11-14H2,1H3,(H,25,28)
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Janssen Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50303656
PNG
((R)-2-[4-(4-Thiophen-3-yl-benzyl)phenoxymethyl]pyr...)
Show SMILES C(Oc1ccc(Cc2ccc(cc2)-c2ccsc2)cc1)[C@H]1CCCN1
Show InChI InChI=1S/C22H23NOS/c1-2-21(23-12-1)15-24-22-9-5-18(6-10-22)14-17-3-7-19(8-4-17)20-11-13-25-16-20/h3-11,13,16,21,23H,1-2,12,14-15H2/t21-/m1/s1
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n/an/a 4n/an/an/an/an/an/a



deCODE Chemistry, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant LTA4H hydrolysis assessed as inhibition of LTB4 formation by LC-MS/MS


Citation and Details
Checked by Author
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50251805
PNG
(CHEMBL481171 | endo-4-((3-(4-(4-(1H-pyrrol-1-yl)ph...)
Show SMILES OC(=O)c1ccc(CN2[C@H]3CC[C@@H]2C[C@@H](C3)Nc2ccc(Oc3ccc(cc3)-n3cccc3)cc2)cc1
Show InChI InChI=1S/C31H31N3O3/c35-31(36)23-5-3-22(4-6-23)21-34-27-9-10-28(34)20-25(19-27)32-24-7-13-29(14-8-24)37-30-15-11-26(12-16-30)33-17-1-2-18-33/h1-8,11-18,25,27-28,32H,9-10,19-21H2,(H,35,36)/t25-,27+,28-
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Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24206
PNG
(2-{4-[2-(azepan-1-yl)ethoxy]phenoxy}-1,3-benzoxazo...)
Show SMILES C(CN1CCCCCC1)Oc1ccc(Oc2nc3ccccc3o2)cc1
Show InChI InChI=1S/C21H24N2O3/c1-2-6-14-23(13-5-1)15-16-24-17-9-11-18(12-10-17)25-21-22-19-7-3-4-8-20(19)26-21/h3-4,7-12H,1-2,5-6,13-16H2
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n/an/a 4n/an/an/an/a7.422



Johnson & Johnson Pharmaceutical



Assay Description
Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50251420
PNG
(2-((3-((4-(1H-tetrazol-5-yl)benzyl)(methyl)amino)p...)
Show SMILES CN(CCCN(C)Cc1ccc(cc1)-c1nnn[nH]1)CC(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C27H31N7O2/c1-33(19-21-9-11-22(12-10-21)27-29-31-32-30-27)17-6-18-34(2)20-26(35)28-23-13-15-25(16-14-23)36-24-7-4-3-5-8-24/h3-5,7-16H,6,17-20H2,1-2H3,(H,28,35)(H,29,30,31,32)
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Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase (unknown origin) by hydrolase assay


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50425151
PNG
(CHEMBL2313563)
Show SMILES C(N1CCCCC1)c1coc2cc(Oc3nc4ncccc4s3)ccc12
Show InChI InChI=1S/C20H19N3O2S/c1-2-9-23(10-3-1)12-14-13-24-17-11-15(6-7-16(14)17)25-20-22-19-18(26-20)5-4-8-21-19/h4-8,11,13H,1-3,9-10,12H2
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n/an/a 4.60n/an/an/an/an/an/a



Janssen Research& Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of recombinant human LTA4H expressed in Sf9 cells using LTA4 as substrate incubated for 10 mins prior to substrate addition measured after...


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50116542
PNG
(3-{Methyl-[3-(4-thiophen-2-ylmethyl-phenoxy)-propy...)
Show SMILES CN(CCCOc1ccc(Cc2cccs2)cc1)CCC(O)=O
Show InChI InChI=1S/C18H23NO3S/c1-19(11-9-18(20)21)10-3-12-22-16-7-5-15(6-8-16)14-17-4-2-13-23-17/h2,4-8,13H,3,9-12,14H2,1H3,(H,20,21)
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n/an/a 4.70n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human leukotriene A4 hydrolase (LTA-4).


J Med Chem 45: 3482-90 (2002)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50285639
PNG
((S)-2-((R)-2-Cyclohexylmethyl-3-hydroxycarbamoyl-p...)
Show SMILES C[C@H](NC(=O)[C@H](CC1CCCCC1)CC(=O)NO)C(O)=O
Show InChI InChI=1S/C14H24N2O5/c1-9(14(19)20)15-13(18)11(8-12(17)16-21)7-10-5-3-2-4-6-10/h9-11,21H,2-8H2,1H3,(H,15,18)(H,16,17)(H,19,20)/t9-,11+/m0/s1
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n/an/a 5n/an/an/an/an/an/a


TBA

Assay Description
Inhibitory activity against recombinant human Leukotriene A4 hydrolase


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50105264
PNG
(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
Show SMILES C[C@H](NC(=O)[C@@H](CC(=O)NO)Cc1ccccc1)C([O-])=O
Show InChI InChI=1S/C14H18N2O5/c1-9(14(19)20)15-13(18)11(8-12(17)16-21)7-10-5-3-2-4-6-10/h2-6,9,11,21H,7-8H2,1H3,(H,15,18)(H,16,17)(H,19,20)/p-1/t9-,11+/m0/s1
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n/an/a 5n/an/an/an/an/an/a


TBA

Assay Description
Inhibitory activity against recombinant human Leukotriene A4 hydrolase


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50402383
PNG
(CHEMBL2207750)
Show SMILES CC(=O)N1CC2CC1CN2Cc1ccc(Oc2nc3ncccc3s2)cc1
Show InChI InChI=1S/C20H20N4O2S/c1-13(25)24-12-15-9-16(24)11-23(15)10-14-4-6-17(7-5-14)26-20-22-19-18(27-20)3-2-8-21-19/h2-8,15-16H,9-12H2,1H3
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n/an/a 5n/an/an/an/an/an/a



Janssen Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50251743
PNG
(CHEMBL481671 | endo-4-((3-(4-(4-(oxazol-2-yl)pheno...)
Show SMILES OC(=O)c1ccc(CN2[C@H]3CC[C@@H]2C[C@@H](C3)Nc2ccc(Oc3ccc(cc3)-c3ncco3)cc2)cc1
Show InChI InChI=1S/C30H29N3O4/c34-30(35)22-3-1-20(2-4-22)19-33-25-9-10-26(33)18-24(17-25)32-23-7-13-28(14-8-23)37-27-11-5-21(6-12-27)29-31-15-16-36-29/h1-8,11-16,24-26,32H,9-10,17-19H2,(H,34,35)/t24-,25+,26-
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Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50105264
PNG
(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
Show SMILES C[C@H](NC(=O)[C@@H](CC(=O)NO)Cc1ccccc1)C([O-])=O
Show InChI InChI=1S/C14H18N2O5/c1-9(14(19)20)15-13(18)11(8-12(17)16-21)7-10-5-3-2-4-6-10/h2-6,9,11,21H,7-8H2,1H3,(H,15,18)(H,16,17)(H,19,20)/p-1/t9-,11+/m0/s1
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n/an/a 5n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50342776
PNG
(4-((3-(4-(biphenyl-4-yloxy)phenylamino)-6-azabicyc...)
Show SMILES OC(=O)c1ccc(CN2CC3CC(Nc4ccc(Oc5ccc(cc5)-c5ccccc5)cc4)C2CCC3)cc1
Show InChI InChI=1S/C34H34N2O3/c37-34(38)28-11-9-24(10-12-28)22-36-23-25-5-4-8-33(36)32(21-25)35-29-15-19-31(20-16-29)39-30-17-13-27(14-18-30)26-6-2-1-3-7-26/h1-3,6-7,9-20,25,32-33,35H,4-5,8,21-23H2,(H,37,38)
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n/an/a 5n/an/an/an/an/an/a



Gyeongsang National University (GNU)

Curated by ChEMBL


Assay Description
Inhibition of human leukotriene A4 hydrolase


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50251473
PNG
(4-((methyl(3-(methyl(2-(4-(4-(oxazol-2-yl)phenoxy)...)
Show SMILES CN(CCCN(C)Cc1ccc(cc1)C(O)=O)CC(=O)Nc1ccc(Oc2ccc(cc2)-c2ncco2)cc1
Show InChI InChI=1S/C30H32N4O5/c1-33(20-22-4-6-24(7-5-22)30(36)37)17-3-18-34(2)21-28(35)32-25-10-14-27(15-11-25)39-26-12-8-23(9-13-26)29-31-16-19-38-29/h4-16,19H,3,17-18,20-21H2,1-2H3,(H,32,35)(H,36,37)
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n/an/a 5n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase (unknown origin) by hydrolase assay


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50251839
PNG
(CHEMBL480949 | endo-4-{3-[4-(Biphenyl-4-yloxy)-phe...)
Show SMILES OC(=O)c1ccc(CN2[C@H]3CC[C@@H]2C[C@@H](C3)Nc2ccc(Oc3ccc(cc3)-c3ccccc3)cc2)cc1
Show InChI InChI=1S/C33H32N2O3/c36-33(37)26-8-6-23(7-9-26)22-35-29-14-15-30(35)21-28(20-29)34-27-12-18-32(19-13-27)38-31-16-10-25(11-17-31)24-4-2-1-3-5-24/h1-13,16-19,28-30,34H,14-15,20-22H2,(H,36,37)/t28-,29+,30-
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n/an/a 5n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50251666
PNG
(4-((4-((4-(4-(oxazol-2-yl)phenoxy)phenylamino)meth...)
Show SMILES OC(=O)c1ccc(CN2CCC(CNc3ccc(Oc4ccc(cc4)-c4ncco4)cc3)CC2)cc1
Show InChI InChI=1S/C29H29N3O4/c33-29(34)24-3-1-22(2-4-24)20-32-16-13-21(14-17-32)19-31-25-7-11-27(12-8-25)36-26-9-5-23(6-10-26)28-30-15-18-35-28/h1-12,15,18,21,31H,13-14,16-17,19-20H2,(H,33,34)
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n/an/a 5n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50085261
PNG
(CHEMBL163478 | [2-(4-Benzyl-phenoxy)-ethyl]-dimeth...)
Show SMILES CN(C)CCOc1ccc(Cc2ccccc2)cc1
Show InChI InChI=1S/C17H21NO/c1-18(2)12-13-19-17-10-8-16(9-11-17)14-15-6-4-3-5-7-15/h3-11H,12-14H2,1-2H3
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n/an/a 6n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM24216
PNG
(1-{2-[4-(1,3-benzoxazol-2-yloxy)phenoxy]ethyl}-4-p...)
Show SMILES OC1(CCN(CCOc2ccc(Oc3nc4ccccc4o3)cc2)CC1)c1ccccc1
Show InChI InChI=1S/C26H26N2O4/c29-26(20-6-2-1-3-7-20)14-16-28(17-15-26)18-19-30-21-10-12-22(13-11-21)31-25-27-23-8-4-5-9-24(23)32-25/h1-13,29H,14-19H2
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n/an/a 6n/an/an/an/a7.422



Johnson & Johnson Pharmaceutical



Assay Description
Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50402388
PNG
(CHEMBL2207745)
Show SMILES CC(=O)N1CC2CN(CCc3ccc(Oc4nc5ncccc5s4)cc3)CC2C1
Show InChI InChI=1S/C22H24N4O2S/c1-15(27)26-13-17-11-25(12-18(17)14-26)10-8-16-4-6-19(7-5-16)28-22-24-21-20(29-22)3-2-9-23-21/h2-7,9,17-18H,8,10-14H2,1H3
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n/an/a 6n/an/an/an/an/an/a



Janssen Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50402395
PNG
(CHEMBL2207738)
Show SMILES O=C1CCCN1C1CCN(CCOc2ccc(Oc3nc4ncccc4s3)cc2)CC1
Show InChI InChI=1S/C23H26N4O3S/c28-21-4-2-12-27(21)17-9-13-26(14-10-17)15-16-29-18-5-7-19(8-6-18)30-23-25-22-20(31-23)3-1-11-24-22/h1,3,5-8,11,17H,2,4,9-10,12-16H2
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n/an/a 6n/an/an/an/an/an/a



Janssen Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50402405
PNG
(CHEMBL2207752)
Show SMILES NC(=O)C1CCN(Cc2ccc(Oc3nc4ncccc4s3)cc2)CC1
Show InChI InChI=1S/C19H20N4O2S/c20-17(24)14-7-10-23(11-8-14)12-13-3-5-15(6-4-13)25-19-22-18-16(26-19)2-1-9-21-18/h1-6,9,14H,7-8,10-12H2,(H2,20,24)
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Janssen Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM50251775
PNG
(CHEMBL480347 | endo-4-((3-(4-(4-chlorophenoxy)phen...)
Show SMILES OC(=O)c1ccc(CN2[C@H]3CC[C@@H]2C[C@@H](C3)Nc2ccc(Oc3ccc(Cl)cc3)cc2)cc1
Show InChI InChI=1S/C27H27ClN2O3/c28-20-5-11-25(12-6-20)33-26-13-7-21(8-14-26)29-22-15-23-9-10-24(16-22)30(23)17-18-1-3-19(4-2-18)27(31)32/h1-8,11-14,22-24,29H,9-10,15-17H2,(H,31,32)/t22-,23+,24-
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Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
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