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Compile Data Set for Download or QSAR

Found 94 hits Enz. Inhib. hit(s) with Target = 'Lipoprotein lipase'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lipoprotein lipase


(Rattus norvegicus)
BDBM50254432
PNG
(1-(2-methyl-5-(morpholinosulfonyl)furan-3-yl)-3-ph...)
Show SMILES Cc1oc(cc1NC(=O)Nc1ccccc1)S(=O)(=O)N1CCOCC1
Show InChI InChI=1S/C16H19N3O5S/c1-12-14(18-16(20)17-13-5-3-2-4-6-13)11-15(24-12)25(21,22)19-7-9-23-10-8-19/h2-6,11H,7-10H2,1H3,(H2,17,18,20)
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n/an/a 40n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Lipoprotein lipase from adipose tissue of rat


Bioorg Med Chem Lett 19: 27-30 (2008)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Rattus norvegicus)
BDBM50254434
PNG
(5-Methyl-4-(3-phenyl-ureido)-furan-2-sulfonic acid...)
Show SMILES COCCN(C)S(=O)(=O)c1cc(NC(=O)Nc2ccccc2)c(C)o1
Show InChI InChI=1S/C16H21N3O5S/c1-12-14(18-16(20)17-13-7-5-4-6-8-13)11-15(24-12)25(21,22)19(2)9-10-23-3/h4-8,11H,9-10H2,1-3H3,(H2,17,18,20)
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n/an/a 50n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Lipoprotein lipase from adipose tissue of rat


Bioorg Med Chem Lett 19: 27-30 (2008)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Rattus norvegicus)
BDBM50254436
PNG
(5-Methyl-4-(3-phenyl-ureido)-furan-2-sulfonic acid...)
Show SMILES CN(C)S(=O)(=O)c1cc(NC(=O)Nc2ccccc2)c(C)o1
Show InChI InChI=1S/C14H17N3O4S/c1-10-12(9-13(21-10)22(19,20)17(2)3)16-14(18)15-11-7-5-4-6-8-11/h4-9H,1-3H3,(H2,15,16,18)
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n/an/a 100n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Lipoprotein lipase from adipose tissue of rat


Bioorg Med Chem Lett 19: 27-30 (2008)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Rattus norvegicus)
BDBM50254290
PNG
(1-(2-methyl-5-(piperidin-1-ylsulfonyl)furan-3-yl)-...)
Show SMILES Cc1oc(cc1NC(=O)Nc1ccccc1)S(=O)(=O)N1CCCCC1
Show InChI InChI=1S/C17H21N3O4S/c1-13-15(19-17(21)18-14-8-4-2-5-9-14)12-16(24-13)25(22,23)20-10-6-3-7-11-20/h2,4-5,8-9,12H,3,6-7,10-11H2,1H3,(H2,18,19,21)
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n/an/a 100n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Lipoprotein lipase from adipose tissue of rat


Bioorg Med Chem Lett 19: 27-30 (2008)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Rattus norvegicus)
BDBM50254339
PNG
(1-(4-methoxyphenyl)-3-(2-methyl-5-(piperidin-1-yls...)
Show SMILES COc1ccc(NC(=O)Nc2cc(oc2C)S(=O)(=O)N2CCCCC2)cc1
Show InChI InChI=1S/C18H23N3O5S/c1-13-16(20-18(22)19-14-6-8-15(25-2)9-7-14)12-17(26-13)27(23,24)21-10-4-3-5-11-21/h6-9,12H,3-5,10-11H2,1-2H3,(H2,19,20,22)
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n/an/a 130n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Lipoprotein lipase from adipose tissue of rat


Bioorg Med Chem Lett 19: 27-30 (2008)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Rattus norvegicus)
BDBM50254340
PNG
(1-(4-chlorophenyl)-3-(2-methyl-5-(piperidin-1-ylsu...)
Show SMILES Cc1oc(cc1NC(=O)Nc1ccc(Cl)cc1)S(=O)(=O)N1CCCCC1
Show InChI InChI=1S/C17H20ClN3O4S/c1-12-15(20-17(22)19-14-7-5-13(18)6-8-14)11-16(25-12)26(23,24)21-9-3-2-4-10-21/h5-8,11H,2-4,9-10H2,1H3,(H2,19,20,22)
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n/an/a 130n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Lipoprotein lipase from adipose tissue of rat


Bioorg Med Chem Lett 19: 27-30 (2008)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Homo sapiens)
BDBM50138739
PNG
(4-tert-Butyl-N-[4-(5-methoxy-2-oxo-[1,3,4]oxadiazo...)
Show SMILES COc1nn(-c2ccc(NC(=O)c3ccc(cc3)C(C)(C)C)cc2)c(=O)o1
Show InChI InChI=1S/C20H21N3O4/c1-20(2,3)14-7-5-13(6-8-14)17(24)21-15-9-11-16(12-10-15)23-19(25)27-18(22-23)26-4/h5-12H,1-4H3,(H,21,24)
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n/an/a 200n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Compound was tested to inhibit lipoprotein lipase (LPL)


J Med Chem 47: 400-10 (2004)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Rattus norvegicus)
BDBM50254341
PNG
(1-(2-chlorophenyl)-3-(2-methyl-5-(piperidin-1-ylsu...)
Show SMILES Cc1oc(cc1NC(=O)Nc1ccccc1Cl)S(=O)(=O)N1CCCCC1
Show InChI InChI=1S/C17H20ClN3O4S/c1-12-15(20-17(22)19-14-8-4-3-7-13(14)18)11-16(25-12)26(23,24)21-9-5-2-6-10-21/h3-4,7-8,11H,2,5-6,9-10H2,1H3,(H2,19,20,22)
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n/an/a 320n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Lipoprotein lipase from adipose tissue of rat


Bioorg Med Chem Lett 19: 27-30 (2008)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Rattus norvegicus)
BDBM50254343
PNG
((S)-1-(2-methyl-5-(piperidin-1-ylsulfonyl)furan-3-...)
Show SMILES C[C@H](NC(=O)Nc1cc(oc1C)S(=O)(=O)N1CCCCC1)c1ccccc1
Show InChI InChI=1S/C19H25N3O4S/c1-14(16-9-5-3-6-10-16)20-19(23)21-17-13-18(26-15(17)2)27(24,25)22-11-7-4-8-12-22/h3,5-6,9-10,13-14H,4,7-8,11-12H2,1-2H3,(H2,20,21,23)/t14-/m0/s1
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n/an/a 400n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Lipoprotein lipase from adipose tissue of rat


Bioorg Med Chem Lett 19: 27-30 (2008)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Rattus norvegicus)
BDBM50254435
PNG
(5-Methyl-4-(3-phenyl-ureido)-furan-2-sulfonic acid...)
Show SMILES Cc1oc(cc1NC(=O)Nc1ccccc1)S(=O)(=O)Nc1ccccc1
Show InChI InChI=1S/C18H17N3O4S/c1-13-16(20-18(22)19-14-8-4-2-5-9-14)12-17(25-13)26(23,24)21-15-10-6-3-7-11-15/h2-12,21H,1H3,(H2,19,20,22)
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n/an/a 400n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Lipoprotein lipase from adipose tissue of rat


Bioorg Med Chem Lett 19: 27-30 (2008)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Rattus norvegicus)
BDBM50254433
PNG
(1-(2-methyl-5-(4-methylpiperazin-1-ylsulfonyl)fura...)
Show SMILES CN1CCN(CC1)S(=O)(=O)c1cc(NC(=O)Nc2ccccc2)c(C)o1
Show InChI InChI=1S/C17H22N4O4S/c1-13-15(19-17(22)18-14-6-4-3-5-7-14)12-16(25-13)26(23,24)21-10-8-20(2)9-11-21/h3-7,12H,8-11H2,1-2H3,(H2,18,19,22)
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n/an/a 500n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Lipoprotein lipase from adipose tissue of rat


Bioorg Med Chem Lett 19: 27-30 (2008)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Homo sapiens)
BDBM26134
PNG
((4-nonylphenyl)boranediol | Phenylboronic Acid, 13)
Show SMILES CCCCCCCCCc1ccc(cc1)B(O)O
Show InChI InChI=1S/C15H25BO2/c1-2-3-4-5-6-7-8-9-14-10-12-15(13-11-14)16(17)18/h10-13,17-18H,2-9H2,1H3
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n/an/a 1.40E+3n/an/an/an/an/an/a



Tufts University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human lipoprotein lipase expressed in HEK293 cells using bis-BD-PC and mono-BD-TG as substrate incubated for 10 mins prior to substrate...


Bioorg Med Chem Lett 22: 1397-401 (2012)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Homo sapiens)
BDBM50364285
PNG
(CHEMBL1952298)
Show SMILES CCCCCCCCCCCc1ccc(cc1)B(O)O
Show InChI InChI=1S/C17H29BO2/c1-2-3-4-5-6-7-8-9-10-11-16-12-14-17(15-13-16)18(19)20/h12-15,19-20H,2-11H2,1H3
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n/an/a 1.50E+3n/an/an/an/an/an/a



Tufts University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human lipoprotein lipase expressed in HEK293 cells using bis-BD-PC and mono-BD-TG as substrate incubated for 10 mins prior to substrate...


Bioorg Med Chem Lett 22: 1397-401 (2012)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Homo sapiens)
BDBM50433472
PNG
(CHEMBL2381069)
Show SMILES Fc1ccccc1CSC(=O)NCCCCCCc1ccccc1
Show InChI InChI=1S/C20H24FNOS/c21-19-14-8-7-13-18(19)16-24-20(23)22-15-9-2-1-4-10-17-11-5-3-6-12-17/h3,5-8,11-14H,1-2,4,9-10,15-16H2,(H,22,23)
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n/an/a 1.69E+3n/an/an/an/an/an/a



Janssen Research and Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of human LPL expressed in HEK293 cells using PED-A1 as substrate by spectrophotometry


Bioorg Med Chem Lett 23: 2595-7 (2013)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Rattus norvegicus)
BDBM50254393
PNG
(1-benzhydryl-3-(2-methyl-5-(piperidin-1-ylsulfonyl...)
Show SMILES Cc1oc(cc1NC(=O)NC(c1ccccc1)c1ccccc1)S(=O)(=O)N1CCCCC1
Show InChI InChI=1S/C24H27N3O4S/c1-18-21(17-22(31-18)32(29,30)27-15-9-4-10-16-27)25-24(28)26-23(19-11-5-2-6-12-19)20-13-7-3-8-14-20/h2-3,5-8,11-14,17,23H,4,9-10,15-16H2,1H3,(H2,25,26,28)
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n/an/a 2.50E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Lipoprotein lipase from adipose tissue of rat


Bioorg Med Chem Lett 19: 27-30 (2008)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Homo sapiens)
BDBM50444153
PNG
(CHEMBL3093304)
Show SMILES OC(=O)c1cc(ccc1N1CCC(Cc2ccc(F)cc2)C1)C(F)(F)F
Show InChI InChI=1S/C19H17F4NO2/c20-15-4-1-12(2-5-15)9-13-7-8-24(11-13)17-6-3-14(19(21,22)23)10-16(17)18(25)26/h1-6,10,13H,7-9,11H2,(H,25,26)
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n/an/a 2.56E+3n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of recombinant human lipoprotein lipase using bis-BODIPY-FL C11-PC as substrate preincubated for 30 mins followed by substrate addition by...


Bioorg Med Chem 21: 7724-34 (2013)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Homo sapiens)
BDBM50364283
PNG
(CHEMBL1952296)
Show SMILES CCCCCc1ccc(cc1)B(O)O
Show InChI InChI=1S/C11H17BO2/c1-2-3-4-5-10-6-8-11(9-7-10)12(13)14/h6-9,13-14H,2-5H2,1H3
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n/an/a 3.80E+3n/an/an/an/an/an/a



Tufts University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human lipoprotein lipase expressed in HEK293 cells using bis-BD-PC and mono-BD-TG as substrate incubated for 10 mins prior to substrate...


Bioorg Med Chem Lett 22: 1397-401 (2012)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Rattus norvegicus)
BDBM50253974
PNG
(1-phenyl-3-(5-(piperidin-1-ylsulfonyl)furan-3-yl)u...)
Show SMILES O=C(Nc1coc(c1)S(=O)(=O)N1CCCCC1)Nc1ccccc1
Show InChI InChI=1S/C16H19N3O4S/c20-16(17-13-7-3-1-4-8-13)18-14-11-15(23-12-14)24(21,22)19-9-5-2-6-10-19/h1,3-4,7-8,11-12H,2,5-6,9-10H2,(H2,17,18,20)
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n/an/a 4.00E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Lipoprotein lipase from adipose tissue of rat


Bioorg Med Chem Lett 19: 27-30 (2008)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Homo sapiens)
BDBM50364295
PNG
(CHEMBL1952307)
Show SMILES CC1(C)OB(OC1(C)C)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C18H21BO2/c1-17(2)18(3,4)21-19(20-17)16-12-10-15(11-13-16)14-8-6-5-7-9-14/h5-13H,1-4H3
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n/an/a 4.40E+3n/an/an/an/an/an/a



Tufts University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human lipoprotein lipase expressed using recombinant adenovirus using glycerol-tri[9,10(n)-3H]oleate after 1 hr by vesicle assay


Bioorg Med Chem Lett 22: 1397-401 (2012)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Homo sapiens)
BDBM50364298
PNG
(CHEMBL1952310)
Show SMILES CC1(C)OB(OC1(C)C)c1ccc(cc1)-c1cccs1
Show InChI InChI=1S/C16H19BO2S/c1-15(2)16(3,4)19-17(18-15)13-9-7-12(8-10-13)14-6-5-11-20-14/h5-11H,1-4H3
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n/an/a 7.00E+3n/an/an/an/an/an/a



Tufts University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human lipoprotein lipase expressed using recombinant adenovirus using glycerol-tri[9,10(n)-3H]oleate after 1 hr by vesicle assay


Bioorg Med Chem Lett 22: 1397-401 (2012)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Homo sapiens)
BDBM50364282
PNG
(CHEMBL1952295)
Show SMILES CCCc1ccc(cc1)B(O)O
Show InChI InChI=1S/C9H13BO2/c1-2-3-8-4-6-9(7-5-8)10(11)12/h4-7,11-12H,2-3H2,1H3
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n/an/a 8.00E+3n/an/an/an/an/an/a



Tufts University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human lipoprotein lipase expressed using recombinant adenovirus using glycerol-tri[9,10(n)-3H]oleate after 1 hr by vesicle assay


Bioorg Med Chem Lett 22: 1397-401 (2012)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Homo sapiens)
BDBM50067895
PNG
(CHEMBL140780 | Tolyl boronic acid | p-tolylboronic...)
Show SMILES Cc1ccc(cc1)B(O)O
Show InChI InChI=1S/C7H9BO2/c1-6-2-4-7(5-3-6)8(9)10/h2-5,9-10H,1H3
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n/an/a 9.00E+3n/an/an/an/an/an/a



Tufts University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human lipoprotein lipase expressed using recombinant adenovirus using glycerol-tri[9,10(n)-3H]oleate after 1 hr by vesicle assay


Bioorg Med Chem Lett 22: 1397-401 (2012)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Homo sapiens)
BDBM50364281
PNG
(CHEMBL1952294)
Show SMILES CCc1ccc(cc1)B(O)O
Show InChI InChI=1S/C8H11BO2/c1-2-7-3-5-8(6-4-7)9(10)11/h3-6,10-11H,2H2,1H3
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n/an/a 9.00E+3n/an/an/an/an/an/a



Tufts University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human lipoprotein lipase expressed using recombinant adenovirus using glycerol-tri[9,10(n)-3H]oleate after 1 hr by vesicle assay


Bioorg Med Chem Lett 22: 1397-401 (2012)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Homo sapiens)
BDBM50364284
PNG
(CHEMBL1952297)
Show SMILES CCCCCCCc1ccc(cc1)B(O)O
Show InChI InChI=1S/C13H21BO2/c1-2-3-4-5-6-7-12-8-10-13(11-9-12)14(15)16/h8-11,15-16H,2-7H2,1H3
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n/an/a 9.00E+3n/an/an/an/an/an/a



Tufts University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human lipoprotein lipase expressed in HEK293 cells using bis-BD-PC and mono-BD-TG as substrate incubated for 10 mins prior to substrate...


Bioorg Med Chem Lett 22: 1397-401 (2012)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Homo sapiens)
BDBM50364297
PNG
(CHEMBL1952309)
Show SMILES CC1(C)OB(OC1(C)C)c1ccc(cc1)-c1ccco1
Show InChI InChI=1S/C16H19BO3/c1-15(2)16(3,4)20-17(19-15)13-9-7-12(8-10-13)14-6-5-11-18-14/h5-11H,1-4H3
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n/an/a 9.60E+3n/an/an/an/an/an/a



Tufts University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human lipoprotein lipase expressed using recombinant adenovirus using glycerol-tri[9,10(n)-3H]oleate after 1 hr by vesicle assay


Bioorg Med Chem Lett 22: 1397-401 (2012)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Homo sapiens)
BDBM50138734
PNG
(3-(3-(benzyloxy)phenyl)-5-ethoxy-1,3,4-oxadiazol-2...)
Show SMILES CCOc1nn(-c2cccc(OCc3ccccc3)c2)c(=O)o1
Show InChI InChI=1S/C17H16N2O4/c1-2-21-16-18-19(17(20)23-16)14-9-6-10-15(11-14)22-12-13-7-4-3-5-8-13/h3-11H,2,12H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Compound was tested to inhibit lipoprotein lipase (LPL)


J Med Chem 47: 400-10 (2004)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Homo sapiens)
BDBM50444145
PNG
(CHEMBL3093405)
Show SMILES OC(=O)c1cc(ccc1NCC1CC1)C(F)(F)F
Show InChI InChI=1S/C12H12F3NO2/c13-12(14,15)8-3-4-10(9(5-8)11(17)18)16-6-7-1-2-7/h3-5,7,16H,1-2,6H2,(H,17,18)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of recombinant human lipoprotein lipase using bis-BODIPY-FL C11-PC as substrate preincubated for 30 mins followed by substrate addition by...


Bioorg Med Chem 21: 7724-34 (2013)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Homo sapiens)
BDBM50364295
PNG
(CHEMBL1952307)
Show SMILES CC1(C)OB(OC1(C)C)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C18H21BO2/c1-17(2)18(3,4)21-19(20-17)16-12-10-15(11-13-16)14-8-6-5-7-9-14/h5-13H,1-4H3
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n/an/a 1.20E+4n/an/an/an/an/an/a



Tufts University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human lipoprotein lipase expressed in HEK293 cells using bis-BD-PC and mono-BD-TG as substrate incubated for 10 mins prior to substrate...


Bioorg Med Chem Lett 22: 1397-401 (2012)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Homo sapiens)
BDBM50364282
PNG
(CHEMBL1952295)
Show SMILES CCCc1ccc(cc1)B(O)O
Show InChI InChI=1S/C9H13BO2/c1-2-3-8-4-6-9(7-5-8)10(11)12/h4-7,11-12H,2-3H2,1H3
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n/an/a 1.25E+4n/an/an/an/an/an/a



Tufts University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human lipoprotein lipase expressed in HEK293 cells using bis-BD-PC and mono-BD-TG as substrate incubated for 10 mins prior to substrate...


Bioorg Med Chem Lett 22: 1397-401 (2012)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Homo sapiens)
BDBM50364300
PNG
(CHEMBL1952312)
Show SMILES CC1(C)OB(OC1(C)C)c1ccc(cc1)-c1ccsc1
Show InChI InChI=1S/C16H19BO2S/c1-15(2)16(3,4)19-17(18-15)14-7-5-12(6-8-14)13-9-10-20-11-13/h5-11H,1-4H3
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n/an/a 1.30E+4n/an/an/an/an/an/a



Tufts University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human lipoprotein lipase expressed using recombinant adenovirus using glycerol-tri[9,10(n)-3H]oleate after 1 hr by vesicle assay


Bioorg Med Chem Lett 22: 1397-401 (2012)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Homo sapiens)
BDBM50364299
PNG
(CHEMBL1952311)
Show SMILES CC1(C)OB(OC1(C)C)c1ccc(cc1)-c1ccoc1
Show InChI InChI=1S/C16H19BO3/c1-15(2)16(3,4)20-17(19-15)14-7-5-12(6-8-14)13-9-10-18-11-13/h5-11H,1-4H3
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n/an/a 1.50E+4n/an/an/an/an/an/a



Tufts University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human lipoprotein lipase expressed using recombinant adenovirus using glycerol-tri[9,10(n)-3H]oleate after 1 hr by vesicle assay


Bioorg Med Chem Lett 22: 1397-401 (2012)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Homo sapiens)
BDBM50364301
PNG
(CHEMBL1952313)
Show SMILES CC1(C)OB(OC1(C)C)c1ccc(cc1)-c1ccc2ccccc2c1
Show InChI InChI=1S/C22H23BO2/c1-21(2)22(3,4)25-23(24-21)20-13-11-17(12-14-20)19-10-9-16-7-5-6-8-18(16)15-19/h5-15H,1-4H3
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n/an/a 1.50E+4n/an/an/an/an/an/a



Tufts University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human lipoprotein lipase expressed in HEK293 cells using bis-BD-PC and mono-BD-TG as substrate incubated for 10 mins prior to substrate...


Bioorg Med Chem Lett 22: 1397-401 (2012)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Homo sapiens)
BDBM50364292
PNG
(CHEMBL1949700)
Show SMILES CCCCCCCCCc1ccc(cc1)B1OC(C)(C)C(C)(C)O1
Show InChI InChI=1S/C21H35BO2/c1-6-7-8-9-10-11-12-13-18-14-16-19(17-15-18)22-23-20(2,3)21(4,5)24-22/h14-17H,6-13H2,1-5H3
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n/an/a 1.50E+4n/an/an/an/an/an/a



Tufts University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human lipoprotein lipase expressed in HEK293 cells using bis-BD-PC and mono-BD-TG as substrate incubated for 10 mins prior to substrate...


Bioorg Med Chem Lett 22: 1397-401 (2012)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Homo sapiens)
BDBM50364293
PNG
(CHEMBL1952305)
Show SMILES CCCCCCCCCCCc1ccc(cc1)B1OC(C)(C)C(C)(C)O1
Show InChI InChI=1S/C23H39BO2/c1-6-7-8-9-10-11-12-13-14-15-20-16-18-21(19-17-20)24-25-22(2,3)23(4,5)26-24/h16-19H,6-15H2,1-5H3
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n/an/a 1.50E+4n/an/an/an/an/an/a



Tufts University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human lipoprotein lipase expressed in HEK293 cells using bis-BD-PC and mono-BD-TG as substrate incubated for 10 mins prior to substrate...


Bioorg Med Chem Lett 22: 1397-401 (2012)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Homo sapiens)
BDBM50364283
PNG
(CHEMBL1952296)
Show SMILES CCCCCc1ccc(cc1)B(O)O
Show InChI InChI=1S/C11H17BO2/c1-2-3-4-5-10-6-8-11(9-7-10)12(13)14/h6-9,13-14H,2-5H2,1H3
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n/an/a 1.50E+4n/an/an/an/an/an/a



Tufts University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human lipoprotein lipase expressed using recombinant adenovirus using glycerol-tri[9,10(n)-3H]oleate after 1 hr by vesicle assay


Bioorg Med Chem Lett 22: 1397-401 (2012)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Rattus norvegicus)
BDBM50254396
PNG
(1-methyl-1-(2-methyl-5-(piperidin-1-ylsulfonyl)fur...)
Show SMILES CN(C(=O)Nc1ccccc1)c1cc(oc1C)S(=O)(=O)N1CCCCC1
Show InChI InChI=1S/C18H23N3O4S/c1-14-16(20(2)18(22)19-15-9-5-3-6-10-15)13-17(25-14)26(23,24)21-11-7-4-8-12-21/h3,5-6,9-10,13H,4,7-8,11-12H2,1-2H3,(H,19,22)
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n/an/a 1.60E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of Lipoprotein lipase from adipose tissue of rat


Bioorg Med Chem Lett 19: 27-30 (2008)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Homo sapiens)
BDBM50364291
PNG
(CHEMBL1952304)
Show SMILES CCCCCCCc1ccc(cc1)B1OC(C)(C)C(C)(C)O1
Show InChI InChI=1S/C19H31BO2/c1-6-7-8-9-10-11-16-12-14-17(15-13-16)20-21-18(2,3)19(4,5)22-20/h12-15H,6-11H2,1-5H3
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n/an/a 1.90E+4n/an/an/an/an/an/a



Tufts University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human lipoprotein lipase expressed in HEK293 cells using bis-BD-PC and mono-BD-TG as substrate incubated for 10 mins prior to substrate...


Bioorg Med Chem Lett 22: 1397-401 (2012)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Homo sapiens)
BDBM50444138
PNG
(CHEMBL3093392)
Show SMILES OC(=O)c1cc(ccc1N1CC[C@@H](C1)OCc1ccccn1)C(F)(F)F
Show InChI InChI=1S/C18H17F3N2O3/c19-18(20,21)12-4-5-16(15(9-12)17(24)25)23-8-6-14(10-23)26-11-13-3-1-2-7-22-13/h1-5,7,9,14H,6,8,10-11H2,(H,24,25)/t14-/m0/s1
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n/an/a 2.00E+4n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of recombinant human lipoprotein lipase using bis-BODIPY-FL C11-PC as substrate preincubated for 30 mins followed by substrate addition by...


Bioorg Med Chem 21: 7724-34 (2013)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Homo sapiens)
BDBM50364281
PNG
(CHEMBL1952294)
Show SMILES CCc1ccc(cc1)B(O)O
Show InChI InChI=1S/C8H11BO2/c1-2-7-3-5-8(6-4-7)9(10)11/h3-6,10-11H,2H2,1H3
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n/an/a 2.00E+4n/an/an/an/an/an/a



Tufts University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human lipoprotein lipase expressed in HEK293 cells using bis-BD-PC and mono-BD-TG as substrate incubated for 10 mins prior to substrate...


Bioorg Med Chem Lett 22: 1397-401 (2012)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Homo sapiens)
BDBM50444152
PNG
(CHEMBL3093305)
Show SMILES OC(=O)c1cc(ccc1N1CC[C@@H](C1)Oc1ccc(cn1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C18H14F6N2O3/c19-17(20,21)10-1-3-14(13(7-10)16(27)28)26-6-5-12(9-26)29-15-4-2-11(8-25-15)18(22,23)24/h1-4,7-8,12H,5-6,9H2,(H,27,28)/t12-/m0/s1
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n/an/a>2.00E+4n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of recombinant human lipoprotein lipase using bis-BODIPY-FL C11-PC as substrate preincubated for 30 mins followed by substrate addition by...


Bioorg Med Chem 21: 7724-34 (2013)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Homo sapiens)
BDBM50364290
PNG
(CHEMBL1952303)
Show SMILES CCCCCc1ccc(cc1)B1OC(C)(C)C(C)(C)O1
Show InChI InChI=1S/C17H27BO2/c1-6-7-8-9-14-10-12-15(13-11-14)18-19-16(2,3)17(4,5)20-18/h10-13H,6-9H2,1-5H3
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n/an/a 2.10E+4n/an/an/an/an/an/a



Tufts University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human lipoprotein lipase expressed in HEK293 cells using bis-BD-PC and mono-BD-TG as substrate incubated for 10 mins prior to substrate...


Bioorg Med Chem Lett 22: 1397-401 (2012)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Homo sapiens)
BDBM50364301
PNG
(CHEMBL1952313)
Show SMILES CC1(C)OB(OC1(C)C)c1ccc(cc1)-c1ccc2ccccc2c1
Show InChI InChI=1S/C22H23BO2/c1-21(2)22(3,4)25-23(24-21)20-13-11-17(12-14-20)19-10-9-16-7-5-6-8-18(16)15-19/h5-15H,1-4H3
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n/an/a 2.20E+4n/an/an/an/an/an/a



Tufts University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human lipoprotein lipase expressed using recombinant adenovirus using glycerol-tri[9,10(n)-3H]oleate after 1 hr by vesicle assay


Bioorg Med Chem Lett 22: 1397-401 (2012)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Homo sapiens)
BDBM50067895
PNG
(CHEMBL140780 | Tolyl boronic acid | p-tolylboronic...)
Show SMILES Cc1ccc(cc1)B(O)O
Show InChI InChI=1S/C7H9BO2/c1-6-2-4-7(5-3-6)8(9)10/h2-5,9-10H,1H3
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n/an/a 2.50E+4n/an/an/an/an/an/a



Tufts University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human lipoprotein lipase expressed in HEK293 cells using bis-BD-PC and mono-BD-TG as substrate incubated for 10 mins prior to substrate...


Bioorg Med Chem Lett 22: 1397-401 (2012)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Homo sapiens)
BDBM50364289
PNG
(CHEMBL1952302)
Show SMILES CCCc1ccc(cc1)B1OC(C)(C)C(C)(C)O1
Show InChI InChI=1S/C15H23BO2/c1-6-7-12-8-10-13(11-9-12)16-17-14(2,3)15(4,5)18-16/h8-11H,6-7H2,1-5H3
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n/an/a 2.50E+4n/an/an/an/an/an/a



Tufts University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human lipoprotein lipase expressed using recombinant adenovirus using glycerol-tri[9,10(n)-3H]oleate after 1 hr by vesicle assay


Bioorg Med Chem Lett 22: 1397-401 (2012)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Homo sapiens)
BDBM50364289
PNG
(CHEMBL1952302)
Show SMILES CCCc1ccc(cc1)B1OC(C)(C)C(C)(C)O1
Show InChI InChI=1S/C15H23BO2/c1-6-7-12-8-10-13(11-9-12)16-17-14(2,3)15(4,5)18-16/h8-11H,6-7H2,1-5H3
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n/an/a 2.50E+4n/an/an/an/an/an/a



Tufts University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human lipoprotein lipase expressed in HEK293 cells using bis-BD-PC and mono-BD-TG as substrate incubated for 10 mins prior to substrate...


Bioorg Med Chem Lett 22: 1397-401 (2012)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Homo sapiens)
BDBM50364284
PNG
(CHEMBL1952297)
Show SMILES CCCCCCCc1ccc(cc1)B(O)O
Show InChI InChI=1S/C13H21BO2/c1-2-3-4-5-6-7-12-8-10-13(11-9-12)14(15)16/h8-11,15-16H,2-7H2,1H3
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n/an/a 3.00E+4n/an/an/an/an/an/a



Tufts University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human lipoprotein lipase expressed using recombinant adenovirus using glycerol-tri[9,10(n)-3H]oleate after 1 hr by vesicle assay


Bioorg Med Chem Lett 22: 1397-401 (2012)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Homo sapiens)
BDBM50444151
PNG
(CHEMBL3093306)
Show SMILES OC(=O)c1cc(ccc1N1CC[C@@H](C1)Oc1ccc(Cl)nc1)C(F)(F)F
Show InChI InChI=1S/C17H14ClF3N2O3/c18-15-4-2-11(8-22-15)26-12-5-6-23(9-12)14-3-1-10(17(19,20)21)7-13(14)16(24)25/h1-4,7-8,12H,5-6,9H2,(H,24,25)/t12-/m0/s1
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n/an/a 3.16E+4n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of recombinant human lipoprotein lipase using bis-BODIPY-FL C11-PC as substrate preincubated for 30 mins followed by substrate addition by...


Bioorg Med Chem 21: 7724-34 (2013)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Homo sapiens)
BDBM50364299
PNG
(CHEMBL1952311)
Show SMILES CC1(C)OB(OC1(C)C)c1ccc(cc1)-c1ccoc1
Show InChI InChI=1S/C16H19BO3/c1-15(2)16(3,4)20-17(19-15)14-7-5-12(6-8-14)13-9-10-18-11-13/h5-11H,1-4H3
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n/an/a 3.30E+4n/an/an/an/an/an/a



Tufts University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human lipoprotein lipase expressed in HEK293 cells using bis-BD-PC and mono-BD-TG as substrate incubated for 10 mins prior to substrate...


Bioorg Med Chem Lett 22: 1397-401 (2012)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Homo sapiens)
BDBM50364296
PNG
(CHEMBL1952308)
Show SMILES CC1(C)OB(OC1(C)C)c1ccc(cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C18H20BFO2/c1-17(2)18(3,4)22-19(21-17)15-9-5-13(6-10-15)14-7-11-16(20)12-8-14/h5-12H,1-4H3
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n/an/a 3.30E+4n/an/an/an/an/an/a



Tufts University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human lipoprotein lipase expressed in HEK293 cells using bis-BD-PC and mono-BD-TG as substrate incubated for 10 mins prior to substrate...


Bioorg Med Chem Lett 22: 1397-401 (2012)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Homo sapiens)
BDBM50444154
PNG
(CHEMBL3093303)
Show SMILES OC(=O)c1cc(ccc1N1CC[C@H](C1)Oc1ccc(F)cc1)C(F)(F)F
Show InChI InChI=1S/C18H15F4NO3/c19-12-2-4-13(5-3-12)26-14-7-8-23(10-14)16-6-1-11(18(20,21)22)9-15(16)17(24)25/h1-6,9,14H,7-8,10H2,(H,24,25)/t14-/m1/s1
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n/an/a>3.30E+4n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of recombinant human lipoprotein lipase using bis-BODIPY-FL C11-PC as substrate preincubated for 30 mins followed by substrate addition by...


Bioorg Med Chem 21: 7724-34 (2013)

More data for this
Ligand-Target Pair
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