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Compile Data Set for Download or QSAR

Found 36 hits Enz. Inhib. hit(s) with Target = 'Liver glycogen phosphorylase'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Liver glycogen phosphorylase


(Mus musculus)
BDBM50149207
PNG
(2N-(2-{2-[2-(5-chloro-1H-2-indolylcarboxamido)etho...)
Show SMILES Clc1ccc2[nH]c(cc2c1)C(=O)NCCOCCOCCNC(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C24H24Cl2N4O4/c25-17-1-3-19-15(11-17)13-21(29-19)23(31)27-5-7-33-9-10-34-8-6-28-24(32)22-14-16-12-18(26)2-4-20(16)30-22/h1-4,11-14,29-30H,5-10H2,(H,27,31)(H,28,32)
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n/an/a 6n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against glycogen phosphorylase


J Med Chem 47: 3463-82 (2004)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Liver glycogen phosphorylase


(Mus musculus)
BDBM50135552
PNG
(4-{2-[(4-Chloro-pyridine-2-carbonyl)-amino]-phenox...)
Show SMILES OC(=O)c1ccc(Oc2ccccc2NC(=O)c2cc(Cl)ccn2)cc1C(O)=O
Show InChI InChI=1S/C20H13ClN2O6/c21-11-7-8-22-16(9-11)18(24)23-15-3-1-2-4-17(15)29-12-5-6-13(19(25)26)14(10-12)20(27)28/h1-10H,(H,23,24)(H,25,26)(H,27,28)
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n/an/a 14n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against mouse liver glycogen phosphorylase


Bioorg Med Chem Lett 13: 4125-8 (2003)

More data for this
Ligand-Target Pair
Liver glycogen phosphorylase


(Mus musculus)
BDBM50135563
PNG
(4-{2-[(4-Cyano-pyridine-2-carbonyl)-amino]-phenoxy...)
Show SMILES OC(=O)c1ccc(Oc2ccccc2NC(=O)c2cc(ccn2)C#N)cc1C(O)=O
Show InChI InChI=1S/C21H13N3O6/c22-11-12-7-8-23-17(9-12)19(25)24-16-3-1-2-4-18(16)30-13-5-6-14(20(26)27)15(10-13)21(28)29/h1-10H,(H,24,25)(H,26,27)(H,28,29)
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n/an/a 14n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against mouse liver glycogen phosphorylase


Bioorg Med Chem Lett 13: 4125-8 (2003)

More data for this
Ligand-Target Pair
Liver glycogen phosphorylase


(Rattus norvegicus)
BDBM50135552
PNG
(4-{2-[(4-Chloro-pyridine-2-carbonyl)-amino]-phenox...)
Show SMILES OC(=O)c1ccc(Oc2ccccc2NC(=O)c2cc(Cl)ccn2)cc1C(O)=O
Show InChI InChI=1S/C20H13ClN2O6/c21-11-7-8-22-16(9-11)18(24)23-15-3-1-2-4-17(15)29-12-5-6-13(19(25)26)14(10-12)20(27)28/h1-10H,(H,23,24)(H,25,26)(H,27,28)
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n/an/a 16n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against rat liver glycogen phosphorylase


Bioorg Med Chem Lett 13: 4125-8 (2003)

More data for this
Ligand-Target Pair
Liver glycogen phosphorylase


(Mus musculus)
BDBM50135556
PNG
(4-{2-[(4-Methoxy-pyridine-2-carbonyl)-amino]-pheno...)
Show SMILES COc1ccnc(c1)C(=O)Nc1ccccc1Oc1ccc(C(O)=O)c(c1)C(O)=O
Show InChI InChI=1S/C21H16N2O7/c1-29-12-8-9-22-17(11-12)19(24)23-16-4-2-3-5-18(16)30-13-6-7-14(20(25)26)15(10-13)21(27)28/h2-11H,1H3,(H,23,24)(H,25,26)(H,27,28)
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n/an/a 18n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against mouse liver glycogen phosphorylase


Bioorg Med Chem Lett 13: 4125-8 (2003)

More data for this
Ligand-Target Pair
Liver glycogen phosphorylase


(Rattus norvegicus)
BDBM50135563
PNG
(4-{2-[(4-Cyano-pyridine-2-carbonyl)-amino]-phenoxy...)
Show SMILES OC(=O)c1ccc(Oc2ccccc2NC(=O)c2cc(ccn2)C#N)cc1C(O)=O
Show InChI InChI=1S/C21H13N3O6/c22-11-12-7-8-23-17(9-12)19(25)24-16-3-1-2-4-18(16)30-13-5-6-14(20(26)27)15(10-13)21(28)29/h1-10H,(H,24,25)(H,26,27)(H,28,29)
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n/an/a 19n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against rat liver glycogen phosphorylase


Bioorg Med Chem Lett 13: 4125-8 (2003)

More data for this
Ligand-Target Pair
Liver glycogen phosphorylase


(Rattus norvegicus)
BDBM50135556
PNG
(4-{2-[(4-Methoxy-pyridine-2-carbonyl)-amino]-pheno...)
Show SMILES COc1ccnc(c1)C(=O)Nc1ccccc1Oc1ccc(C(O)=O)c(c1)C(O)=O
Show InChI InChI=1S/C21H16N2O7/c1-29-12-8-9-22-17(11-12)19(24)23-16-4-2-3-5-18(16)30-13-6-7-14(20(25)26)15(10-13)21(27)28/h2-11H,1H3,(H,23,24)(H,25,26)(H,27,28)
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n/an/a 24n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against rat liver glycogen phosphorylase


Bioorg Med Chem Lett 13: 4125-8 (2003)

More data for this
Ligand-Target Pair
Liver glycogen phosphorylase


(Mus musculus)
BDBM50065965
PNG
(5-Chloro-1H-indole-2-carboxylic acid ((1S,2R)-1-be...)
Show SMILES CN(C)C(=O)[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C21H22ClN3O3/c1-25(2)21(28)19(26)17(10-13-6-4-3-5-7-13)24-20(27)18-12-14-11-15(22)8-9-16(14)23-18/h3-9,11-12,17,19,23,26H,10H2,1-2H3,(H,24,27)/t17-,19+/m0/s1
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n/an/a 130n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against glycogen phosphorylase


J Med Chem 47: 3463-82 (2004)

More data for this
Ligand-Target Pair
Liver glycogen phosphorylase


(Mus musculus)
BDBM50135549
PNG
(4-[3-Fluoro-2-(3-nitro-benzoylamino)-phenoxy]-phth...)
Show SMILES OC(=O)c1ccc(Oc2cccc(F)c2NC(=O)c2cccc(c2)[N+]([O-])=O)cc1C(O)=O
Show InChI InChI=1S/C21H13FN2O8/c22-16-5-2-6-17(32-13-7-8-14(20(26)27)15(10-13)21(28)29)18(16)23-19(25)11-3-1-4-12(9-11)24(30)31/h1-10H,(H,23,25)(H,26,27)(H,28,29)
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n/an/a 207n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against mouse liver glycogen phosphorylase


Bioorg Med Chem Lett 13: 4125-8 (2003)

More data for this
Ligand-Target Pair
Liver glycogen phosphorylase


(Rattus norvegicus)
BDBM50135549
PNG
(4-[3-Fluoro-2-(3-nitro-benzoylamino)-phenoxy]-phth...)
Show SMILES OC(=O)c1ccc(Oc2cccc(F)c2NC(=O)c2cccc(c2)[N+]([O-])=O)cc1C(O)=O
Show InChI InChI=1S/C21H13FN2O8/c22-16-5-2-6-17(32-13-7-8-14(20(26)27)15(10-13)21(28)29)18(16)23-19(25)11-3-1-4-12(9-11)24(30)31/h1-10H,(H,23,25)(H,26,27)(H,28,29)
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n/an/a 302n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against rat liver glycogen phosphorylase


Bioorg Med Chem Lett 13: 4125-8 (2003)

More data for this
Ligand-Target Pair
Liver glycogen phosphorylase


(Rattus norvegicus)
BDBM50194701
PNG
((2R,3R,4R)-2-Hydroxymethylpyrrolidin-3,4-diol hydr...)
Show SMILES OC[C@H]1[NH2+]C[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C5H11NO3/c7-2-3-5(9)4(8)1-6-3/h3-9H,1-2H2/p+1/t3-,4-,5-/m1/s1
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n/an/a 370n/an/an/an/an/an/a



The National Hellenic Research Foundation

Curated by ChEMBL


Assay Description
Inhibition of phosphorylated form of rat liver glycogen phosphorylase


J Med Chem 49: 5687-701 (2006)

More data for this
Ligand-Target Pair
Liver glycogen phosphorylase


(Rattus norvegicus)
BDBM50182801
PNG
((3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol, 8...)
Show SMILES OC[C@H]1CNC[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m1/s1
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n/an/a 680n/an/an/an/an/an/a



The National Hellenic Research Foundation

Curated by ChEMBL


Assay Description
Inhibition of phosphorylated form of rat liver glycogen phosphorylase


J Med Chem 49: 5687-701 (2006)

More data for this
Ligand-Target Pair
Liver glycogen phosphorylase


(Rattus norvegicus)
BDBM50031485
PNG
((2R,3R,4R)-2-Hydroxymethyl-pyrrolidine-3,4-diol | ...)
Show SMILES OC[C@H]1NC[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C5H11NO3/c7-2-3-5(9)4(8)1-6-3/h3-9H,1-2H2/t3-,4-,5-/m1/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of glycogen phosphorylase in rat hepatocytes assessed as reduction in basal glycogenolysis


Drug Metab Dispos 41: 878-87 (2013)

More data for this
Ligand-Target Pair
Liver glycogen phosphorylase


(Rattus norvegicus)
BDBM50031485
PNG
((2R,3R,4R)-2-Hydroxymethyl-pyrrolidine-3,4-diol | ...)
Show SMILES OC[C@H]1NC[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C5H11NO3/c7-2-3-5(9)4(8)1-6-3/h3-9H,1-2H2/t3-,4-,5-/m1/s1
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n/an/a 1.10E+3n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of glycogen phosphorylase in rat hepatocytes assessed as reduction in glucagom-induced glycogenolysis


Drug Metab Dispos 41: 878-87 (2013)

More data for this
Ligand-Target Pair
Liver glycogen phosphorylase


(Rattus norvegicus)
BDBM50194702
PNG
((3R,4R,5R)-5-(HYDROXYMETHYL)-1-(3-PHENYLPROPYL)PIP...)
Show SMILES OC[C@H]1CN(CCCc2ccccc2)C[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C15H23NO3/c17-11-13-9-16(10-14(18)15(13)19)8-4-7-12-5-2-1-3-6-12/h1-3,5-6,13-15,17-19H,4,7-11H2/t13-,14-,15-/m1/s1
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n/an/a 1.22E+3n/an/an/an/an/an/a



The National Hellenic Research Foundation

Curated by ChEMBL


Assay Description
Inhibition of phosphorylated form of rat liver glycogen phosphorylase


J Med Chem 49: 5687-701 (2006)

More data for this
Ligand-Target Pair
Liver glycogen phosphorylase


(Mus musculus)
BDBM50149237
PNG
(5-Chloro-1H-indole-2-carboxylic acid (2-methoxy-et...)
Show SMILES COCCNC(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C12H13ClN2O2/c1-17-5-4-14-12(16)11-7-8-6-9(13)2-3-10(8)15-11/h2-3,6-7,15H,4-5H2,1H3,(H,14,16)
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n/an/a 1.25E+4n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against glycogen phosphorylase


J Med Chem 47: 3463-82 (2004)

More data for this
Ligand-Target Pair
Liver glycogen phosphorylase


(Rattus norvegicus)
BDBM50146091
PNG
(CHEMBL3765349)
Show SMILES CC(=O)OC[C@H]1O[C@@]2(CC(=NO2)c2ccc3ccccc3c2)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O
Show InChI InChI=1/C26H27NO10/c1-14(28)32-13-22-23(33-15(2)29)24(34-16(3)30)25(35-17(4)31)26(36-22)12-21(27-37-26)20-10-9-18-7-5-6-8-19(18)11-20/h5-11,22-25H,12-13H2,1-4H3/t22-,23-,24+,25-,26-/s2
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n/an/a 1.36E+4n/an/an/an/an/an/a



Universit£ Claude Bernard Lyon 1

Curated by ChEMBL


Assay Description
Inhibition of glycogen phosphorylase in Wistar rat hepatocytes assessed as decrease in glucagon stimulated glucose release after 3 hrs by glucose oxi...


Eur J Med Chem 108: 444-54 (2016)

More data for this
Ligand-Target Pair
Liver glycogen phosphorylase


(Rattus norvegicus)
BDBM50146082
PNG
(CHEMBL3763876)
Show SMILES OC[C@H]1O[C@@]2(CC(=NO2)c2ccc3cc(O)ccc3c2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1/C18H19NO7/c20-8-14-15(22)16(23)17(24)18(25-14)7-13(19-26-18)11-2-1-10-6-12(21)4-3-9(10)5-11/h1-6,14-17,20-24H,7-8H2/t14-,15-,16+,17-,18-/s2
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n/an/a 3.01E+4n/an/an/an/an/an/a



Universit£ Claude Bernard Lyon 1

Curated by ChEMBL


Assay Description
Inhibition of glycogen phosphorylase in Wistar rat hepatocytes assessed as decrease in glucagon stimulated glucose release after 3 hrs by glucose oxi...


Eur J Med Chem 108: 444-54 (2016)

More data for this
Ligand-Target Pair
Liver glycogen phosphorylase


(Rattus norvegicus)
BDBM34110
PNG
(glucopyranosylidene-spiro-isoxazoline, 4e)
Show SMILES OC[C@H]1O[C@@]2(CC(=NO2)c2ccc3ccccc3c2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C18H19NO6/c20-9-14-15(21)16(22)17(23)18(24-14)8-13(19-25-18)12-6-5-10-3-1-2-4-11(10)7-12/h1-7,14-17,20-23H,8-9H2/t14-,15-,16+,17-,18-/m1/s1
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n/an/a 3.60E+4n/an/an/an/an/an/a



Universit£ Claude Bernard Lyon 1

Curated by ChEMBL


Assay Description
Inhibition of glycogen phosphorylase in Wistar rat hepatocytes assessed as decrease in glucagon stimulated glucose release after 3 hrs by glucose oxi...


Eur J Med Chem 108: 444-54 (2016)

More data for this
Ligand-Target Pair
Liver glycogen phosphorylase


(Rattus norvegicus)
BDBM50294476
PNG
((E)-4-(naphthalen-2-yl)-1-((2S,3R,4R,5S,6R)-3,4,5-...)
Show SMILES OC[C@H]1O[C@@H](CC(=O)C=Cc2ccc3ccccc3c2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C20H22O6/c21-11-17-19(24)20(25)18(23)16(26-17)10-15(22)8-6-12-5-7-13-3-1-2-4-14(13)9-12/h1-9,16-21,23-25H,10-11H2/t16-,17+,18-,19+,20+/m0/s1
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n/an/a 9.80E+4n/an/an/an/an/an/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat liver glycogen phosphatase


Bioorg Med Chem Lett 19: 2699-703 (2009)

More data for this
Ligand-Target Pair
Liver glycogen phosphorylase


(Rattus norvegicus)
BDBM50175892
PNG
(2alpha,3beta-dihydroxy-12-oleanen-28-oic acid | 2a...)
Show SMILES CC1(C)CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2C1)C(O)=O
Show InChI InChI=1S/C30H48O4/c1-25(2)12-14-30(24(33)34)15-13-28(6)18(19(30)16-25)8-9-22-27(5)17-20(31)23(32)26(3,4)21(27)10-11-29(22,28)7/h8,19-23,31-32H,9-17H2,1-7H3,(H,33,34)/t19-,20+,21-,22+,23-,27-,28+,29+,30-/m0/s1
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n/an/a 9.90E+4n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat liver glycogen phosphorylase


Bioorg Med Chem Lett 15: 4944-8 (2005)

More data for this
Ligand-Target Pair
Liver glycogen phosphorylase


(Rattus norvegicus)
BDBM50146088
PNG
(CHEMBL3763929)
Show SMILES OC[C@H]1O[C@@]2(CC(=NO2)c2ccc3OCOc3c2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1/C15H17NO8/c17-5-11-12(18)13(19)14(20)15(23-11)4-8(16-24-15)7-1-2-9-10(3-7)22-6-21-9/h1-3,11-14,17-20H,4-6H2/t11-,12-,13+,14-,15-/s2
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universit£ Claude Bernard Lyon 1

Curated by ChEMBL


Assay Description
Inhibition of glycogen phosphorylase in Wistar rat hepatocytes assessed as decrease in glucagon stimulated glucose release after 3 hrs by glucose oxi...


Eur J Med Chem 108: 444-54 (2016)

More data for this
Ligand-Target Pair
Liver glycogen phosphorylase


(Rattus norvegicus)
BDBM50146085
PNG
(CHEMBL3764911)
Show SMILES COc1cc(OC)cc(c1)C1=NO[C@@]2(C1)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O
Show InChI InChI=1/C16H21NO8/c1-22-9-3-8(4-10(5-9)23-2)11-6-16(25-17-11)15(21)14(20)13(19)12(7-18)24-16/h3-5,12-15,18-21H,6-7H2,1-2H3/t12-,13-,14+,15-,16-/s2
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universit£ Claude Bernard Lyon 1

Curated by ChEMBL


Assay Description
Inhibition of glycogen phosphorylase in Wistar rat hepatocytes assessed as decrease in glucagon stimulated glucose release after 3 hrs by glucose oxi...


Eur J Med Chem 108: 444-54 (2016)

More data for this
Ligand-Target Pair
Liver glycogen phosphorylase


(Rattus norvegicus)
BDBM50146086
PNG
(CHEMBL3764775)
Show SMILES CSc1ccc(cc1)C1=NO[C@@]2(C1)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O
Show InChI InChI=1/C15H19NO6S/c1-23-9-4-2-8(3-5-9)10-6-15(22-16-10)14(20)13(19)12(18)11(7-17)21-15/h2-5,11-14,17-20H,6-7H2,1H3/t11-,12-,13+,14-,15-/s2
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universit£ Claude Bernard Lyon 1

Curated by ChEMBL


Assay Description
Inhibition of glycogen phosphorylase in Wistar rat hepatocytes assessed as decrease in glucagon stimulated glucose release after 3 hrs by glucose oxi...


Eur J Med Chem 108: 444-54 (2016)

More data for this
Ligand-Target Pair
Liver glycogen phosphorylase


(Rattus norvegicus)
BDBM50146081
PNG
(CHEMBL3764195)
Show SMILES OC[C@H]1O[C@@]2(CC(=NO2)c2cc3ccccc3c3ccccc23)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1/C22H21NO6/c24-11-18-19(25)20(26)21(27)22(28-18)10-17(23-29-22)16-9-12-5-1-2-6-13(12)14-7-3-4-8-15(14)16/h1-9,18-21,24-27H,10-11H2/t18-,19-,20+,21-,22-/s2
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universit£ Claude Bernard Lyon 1

Curated by ChEMBL


Assay Description
Inhibition of glycogen phosphorylase in Wistar rat hepatocytes assessed as decrease in glucagon stimulated glucose release after 3 hrs by glucose oxi...


Eur J Med Chem 108: 444-54 (2016)

More data for this
Ligand-Target Pair
Liver glycogen phosphorylase


(Rattus norvegicus)
BDBM50146090
PNG
(CHEMBL3763976)
Show SMILES OC[C@H]1O[C@@]2(CC(=NO2)c2ccc3OCCOc3c2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1/C16H19NO8/c18-7-12-13(19)14(20)15(21)16(24-12)6-9(17-25-16)8-1-2-10-11(5-8)23-4-3-22-10/h1-2,5,12-15,18-21H,3-4,6-7H2/t12-,13-,14+,15-,16-/s2
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universit£ Claude Bernard Lyon 1

Curated by ChEMBL


Assay Description
Inhibition of glycogen phosphorylase in Wistar rat hepatocytes assessed as decrease in glucagon stimulated glucose release after 3 hrs by glucose oxi...


Eur J Med Chem 108: 444-54 (2016)

More data for this
Ligand-Target Pair
Liver glycogen phosphorylase


(Rattus norvegicus)
BDBM50222205
PNG
((1S,2R,4aS,6aS,6bR,8aR,10R,11R,12aR,12bR,14bS)-10,...)
Show SMILES C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2[C@H]1C)C(O)=O
Show InChI InChI=1S/C30H48O4/c1-17-10-13-30(25(33)34)15-14-28(6)19(23(30)18(17)2)8-9-22-27(5)16-20(31)24(32)26(3,4)21(27)11-12-29(22,28)7/h8,17-18,20-24,31-32H,9-16H2,1-7H3,(H,33,34)/t17-,18+,20-,21+,22-,23+,24+,27+,28-,29-,30+/m1/s1
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n/an/a 1.01E+5n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat liver glycogen phosphorylase


Bioorg Med Chem Lett 15: 4944-8 (2005)

More data for this
Ligand-Target Pair
Liver glycogen phosphorylase


(Rattus norvegicus)
BDBM10849
PNG
(1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)
Show SMILES Cn1cnc2n(C)c(=O)n(C)c(=O)c12
Show InChI InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3
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n/an/a 6.48E+5n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat liver glycogen phosphorylase


Bioorg Med Chem Lett 15: 4944-8 (2005)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Liver glycogen phosphorylase


(Rattus norvegicus)
BDBM50263769
PNG
((5S,7R,8S,9S,10R)-8,9,10-Trihydroxy-7-hydroxymethy...)
Show SMILES OC[C@H]1O[C@@]2(NC(=S)NC2=O)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C8H12N2O6S/c11-1-2-3(12)4(13)5(14)8(16-2)6(15)9-7(17)10-8/h2-5,11-14H,1H2,(H2,9,10,15,17)/t2-,3-,4+,5-,8+/m1/s1
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7.00E+3n/an/an/an/an/an/an/an/a



Lajos Kossuth University

Curated by ChEMBL


Assay Description
Inhibitor constant was measured against Liver phosphorylase b in rat


Bioorg Med Chem Lett 9: 1385-90 (1999)

More data for this
Ligand-Target Pair
Liver glycogen phosphorylase


(Rattus norvegicus)
BDBM50057754
PNG
(8,9,10-Trihydroxy-7-hydroxymethyl-6-oxa-1,3-diaza-...)
Show SMILES OCC1OC2(NC(=O)NC2=O)C(O)C(O)C1O
Show InChI InChI=1S/C8H12N2O7/c11-1-2-3(12)4(13)5(14)8(17-2)6(15)9-7(16)10-8/h2-5,11-14H,1H2,(H2,9,10,15,16)
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1.28E+4n/an/an/an/an/an/an/an/a



Lajos Kossuth University

Curated by ChEMBL


Assay Description
Inhibitor constant was measured against Liver phosphorylase b in rat


Bioorg Med Chem Lett 9: 1385-90 (1999)

More data for this
Ligand-Target Pair
Liver glycogen phosphorylase


(Rattus norvegicus)
BDBM50057754
PNG
(8,9,10-Trihydroxy-7-hydroxymethyl-6-oxa-1,3-diaza-...)
Show SMILES OCC1OC2(NC(=O)NC2=O)C(O)C(O)C1O
Show InChI InChI=1S/C8H12N2O7/c11-1-2-3(12)4(13)5(14)8(17-2)6(15)9-7(16)10-8/h2-5,11-14H,1H2,(H2,9,10,15,16)
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1.65E+4n/an/an/an/an/an/an/an/a



Lajos Kossuth University

Curated by ChEMBL


Assay Description
Inhibitor constant was measured against Liver phosphorylase a in rat


Bioorg Med Chem Lett 9: 1385-90 (1999)

More data for this
Ligand-Target Pair
Liver glycogen phosphorylase


(Rattus norvegicus)
BDBM50057754
PNG
(8,9,10-Trihydroxy-7-hydroxymethyl-6-oxa-1,3-diaza-...)
Show SMILES OCC1OC2(NC(=O)NC2=O)C(O)C(O)C1O
Show InChI InChI=1S/C8H12N2O7/c11-1-2-3(12)4(13)5(14)8(17-2)6(15)9-7(16)10-8/h2-5,11-14H,1H2,(H2,9,10,15,16)
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1.65E+4n/an/an/an/an/an/an/an/a



Lajos Kossuth University

Curated by ChEMBL


Assay Description
Inhibitor constant was measured against Liver phosphorylase a in rat


Bioorg Med Chem Lett 9: 1385-90 (1999)

More data for this
Ligand-Target Pair
Liver glycogen phosphorylase


(Rattus norvegicus)
BDBM50211294
PNG
((7R,8S,9S,10R)-8,9,10-trihydroxy-7-hydroxymethyl-2...)
Show SMILES OC[C@H]1OC2(NC(=S)NC2=O)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C8H12N2O6S/c11-1-2-3(12)4(13)5(14)8(16-2)6(15)9-7(17)10-8/h2-5,11-14H,1H2,(H2,9,10,15,17)/t2-,3-,4+,5-,8?/m1/s1
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2.98E+4n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of rat liver glycogen phosphorylase


Citation and Details
More data for this
Ligand-Target Pair
Liver glycogen phosphorylase


(Rattus norvegicus)
BDBM50263769
PNG
((5S,7R,8S,9S,10R)-8,9,10-Trihydroxy-7-hydroxymethy...)
Show SMILES OC[C@H]1O[C@@]2(NC(=S)NC2=O)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C8H12N2O6S/c11-1-2-3(12)4(13)5(14)8(16-2)6(15)9-7(17)10-8/h2-5,11-14H,1H2,(H2,9,10,15,17)/t2-,3-,4+,5-,8+/m1/s1
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2.98E+4n/an/an/an/an/an/an/an/a



Lajos Kossuth University

Curated by ChEMBL


Assay Description
Inhibitor constant was measured against Liver phosphorylase a in rat


Bioorg Med Chem Lett 9: 1385-90 (1999)

More data for this
Ligand-Target Pair
Liver glycogen phosphorylase


(Rattus norvegicus)
BDBM50211294
PNG
((7R,8S,9S,10R)-8,9,10-trihydroxy-7-hydroxymethyl-2...)
Show SMILES OC[C@H]1OC2(NC(=S)NC2=O)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C8H12N2O6S/c11-1-2-3(12)4(13)5(14)8(16-2)6(15)9-7(17)10-8/h2-5,11-14H,1H2,(H2,9,10,15,17)/t2-,3-,4+,5-,8?/m1/s1
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2.98E+4n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Inhibition of rat liver glycogen phosphorylase


Eur J Med Chem 76: 567-79 (2014)

More data for this
Ligand-Target Pair
Liver glycogen phosphorylase


(Rattus norvegicus)
BDBM50263769
PNG
((5S,7R,8S,9S,10R)-8,9,10-Trihydroxy-7-hydroxymethy...)
Show SMILES OC[C@H]1O[C@@]2(NC(=S)NC2=O)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C8H12N2O6S/c11-1-2-3(12)4(13)5(14)8(16-2)6(15)9-7(17)10-8/h2-5,11-14H,1H2,(H2,9,10,15,17)/t2-,3-,4+,5-,8+/m1/s1
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2.98E+4n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Inhibition of rat liver glycogen phosphorylase


ACS Med Chem Lett 6: 1215-9 (2015)

More data for this
Ligand-Target Pair