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Compile Data Set for Download or QSAR

Found 68 hits Enz. Inhib. hit(s) with Target = 'Low affinity sodium-glucose cotransporter'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Low affinity sodium-glucose cotransporter


(Homo sapiens)
BDBM50342885
PNG
((1S,2S,3S,4R,5S)-5-[4-Chloro-3-(4-ethoxybenzyl)phe...)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@]23OC[C@](CO)(O2)[C@@H](O)[C@H](O)[C@H]3O)cc1
Show InChI InChI=1S/C22H25ClO7/c1-2-28-16-6-3-13(4-7-16)9-14-10-15(5-8-17(14)23)22-20(27)18(25)19(26)21(11-24,30-22)12-29-22/h3-8,10,18-20,24-27H,2,9,11-12H2,1H3/t18-,19-,20+,21-,22-/m0/s1
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n/an/a 0.877n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of methyl alpha-D-glucopyranoside uptake after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Low affinity sodium-glucose cotransporter


(Homo sapiens)
BDBM50342887
PNG
((1S,2S,3S,4R,5S)-5-[4-Chloro-3-(4-methoxybenzyl)ph...)
Show SMILES COc1ccc(Cc2cc(ccc2Cl)[C@]23OC[C@](CO)(O2)[C@@H](O)[C@H](O)[C@H]3O)cc1
Show InChI InChI=1S/C21H23ClO7/c1-27-15-5-2-12(3-6-15)8-13-9-14(4-7-16(13)22)21-19(26)17(24)18(25)20(10-23,29-21)11-28-21/h2-7,9,17-19,23-26H,8,10-11H2,1H3/t17-,18-,19+,20-,21-/m0/s1
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n/an/a 0.882n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of methyl alpha-D-glucopyranoside uptake after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Low affinity sodium-glucose cotransporter


(Homo sapiens)
BDBM50342889
PNG
((1S,2S,3S,4R,5S)-1-(Hydroxymethyl)-5-[3-(4-methoxy...)
Show SMILES COc1ccc(Cc2cc(ccc2C)[C@]23OC[C@](CO)(O2)[C@@H](O)[C@H](O)[C@H]3O)cc1
Show InChI InChI=1S/C22H26O7/c1-13-3-6-16(10-15(13)9-14-4-7-17(27-2)8-5-14)22-20(26)18(24)19(25)21(11-23,29-22)12-28-22/h3-8,10,18-20,23-26H,9,11-12H2,1-2H3/t18-,19-,20+,21-,22-/m0/s1
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n/an/a 1.07n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of methyl alpha-D-glucopyranoside uptake after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Low affinity sodium-glucose cotransporter


(Homo sapiens)
BDBM50342888
PNG
((1S,2S,3S,4R,5S)-5-[3-(4-Ethoxybenzyl)-4-methylphe...)
Show SMILES CCOc1ccc(Cc2cc(ccc2C)[C@]23OC[C@](CO)(O2)[C@@H](O)[C@H](O)[C@H]3O)cc1
Show InChI InChI=1S/C23H28O7/c1-3-28-18-8-5-15(6-9-18)10-16-11-17(7-4-14(16)2)23-21(27)19(25)20(26)22(12-24,30-23)13-29-23/h4-9,11,19-21,24-27H,3,10,12-13H2,1-2H3/t19-,20-,21+,22-,23-/m0/s1
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n/an/a 1.11n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of methyl alpha-D-glucopyranoside uptake after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
Low affinity sodium-glucose cotransporter


(Homo sapiens)
BDBM20880
PNG
((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1
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n/an/a 1.35n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells using methyl-alpha-D-glucopyranoside by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
sodium-dependent glucose cotransporter 2 (SGLT2)


(Mus musculus (Mouse))
BDBM109275
PNG
(US8609622, 2)
Show SMILES COc1ccc(Cc2cc(ccc2Cl)[C@@]23OC[C@@](CO)(O2)[C@@H](O)[C@H](O)[C@H]3O)c(F)c1F
Show InChI InChI=1S/C21H21ClF2O7/c1-29-14-5-2-10(15(23)16(14)24)6-11-7-12(3-4-13(11)22)21-19(28)17(26)18(27)20(8-25,31-21)9-30-21/h2-5,7,17-19,25-28H,6,8-9H2,1H3/t17-,18-,19+,20+,21+/m0/s1
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US Patent
n/an/a 1.42n/an/an/an/an/an/a



Shanghai Hengrui Pharmaceutical Co., Ltd.; Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
Inhibitory activity of the compounds using SGLT1 and SGLT2.


US Patent US8609622 (2013)

More data for this
Ligand-Target Pair
sodium-dependent glucose cotransporter 2 (SGLT2)


(Mus musculus (Mouse))
BDBM109278
PNG
(US8609622, 5)
Show SMILES OC[C@]12COC(O1)([C@H](O)[C@@H](O)[C@@H]2O)c1ccc(Cl)c(Cc2ccc3OCCc3c2)c1
Show InChI InChI=1S/C22H23ClO7/c23-16-3-2-15(9-14(16)8-12-1-4-17-13(7-12)5-6-28-17)22-20(27)18(25)19(26)21(10-24,30-22)11-29-22/h1-4,7,9,18-20,24-27H,5-6,8,10-11H2/t18-,19-,20+,21+,22?/m0/s1
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US Patent
n/an/a 1.49n/an/an/an/an/an/a



Shanghai Hengrui Pharmaceutical Co., Ltd.; Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
Inhibitory activity of the compounds using SGLT1 and SGLT2.


US Patent US8609622 (2013)

More data for this
Ligand-Target Pair
sodium-dependent glucose cotransporter 2 (SGLT2)


(Mus musculus (Mouse))
BDBM109277
PNG
(US8609622, 4)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)C23OC[C@@](CO)(O2)[C@@H](O)[C@H](O)[C@H]3O)cc1F
Show InChI InChI=1S/C22H24ClFO7/c1-2-29-17-6-3-12(8-16(17)24)7-13-9-14(4-5-15(13)23)22-20(28)18(26)19(27)21(10-25,31-22)11-30-22/h3-6,8-9,18-20,25-28H,2,7,10-11H2,1H3/t18-,19-,20+,21+,22?/m0/s1
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US Patent
n/an/a 3.31n/an/an/an/an/an/a



Shanghai Hengrui Pharmaceutical Co., Ltd.; Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
Inhibitory activity of the compounds using SGLT1 and SGLT2.


US Patent US8609622 (2013)

More data for this
Ligand-Target Pair
sodium-dependent glucose cotransporter 2 (SGLT2)


(Mus musculus (Mouse))
BDBM109275
PNG
(US8609622, 2)
Show SMILES COc1ccc(Cc2cc(ccc2Cl)[C@@]23OC[C@@](CO)(O2)[C@@H](O)[C@H](O)[C@H]3O)c(F)c1F
Show InChI InChI=1S/C21H21ClF2O7/c1-29-14-5-2-10(15(23)16(14)24)6-11-7-12(3-4-13(11)22)21-19(28)17(26)18(27)20(8-25,31-21)9-30-21/h2-5,7,17-19,25-28H,6,8-9H2,1H3/t17-,18-,19+,20+,21+/m0/s1
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US Patent
n/an/a 3.65n/an/an/an/an/an/a



Shanghai Hengrui Pharmaceutical Co., Ltd.; Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
Inhibitory activity of the compounds using SGLT1 and SGLT2.


US Patent US8609622 (2013)

More data for this
Ligand-Target Pair
sodium-dependent glucose cotransporter 2 (SGLT2)


(Mus musculus (Mouse))
BDBM109279
PNG
(US8609622, 7)
Show SMILES OC[C@]12COC(O1)([C@H](O)[C@@H](O)[C@@H]2O)c1ccc(Cl)c(Cc2ccc(OCC(F)(F)F)cc2)c1
Show InChI InChI=1S/C22H22ClF3O7/c23-16-6-3-14(22-19(30)17(28)18(29)20(9-27,33-22)10-32-22)8-13(16)7-12-1-4-15(5-2-12)31-11-21(24,25)26/h1-6,8,17-19,27-30H,7,9-11H2/t17-,18-,19+,20+,22?/m0/s1
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US Patent
n/an/a 4.58n/an/an/an/an/an/a



Shanghai Hengrui Pharmaceutical Co., Ltd.; Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
Inhibitory activity of the compounds using SGLT1 and SGLT2.


US Patent US8609622 (2013)

More data for this
Ligand-Target Pair
Low affinity sodium-glucose cotransporter


(Homo sapiens)
BDBM20878
PNG
((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...)
Show SMILES COc1ccc(Cc2ccccc2O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C20H24O7/c1-25-14-8-6-12(7-9-14)10-13-4-2-3-5-15(13)26-20-19(24)18(23)17(22)16(11-21)27-20/h2-9,16-24H,10-11H2,1H3/t16-,17-,18+,19-,20-/m1/s1
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n/an/a 4.80n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins


Citation and Details
More data for this
Ligand-Target Pair
sodium-dependent glucose cotransporter 2 (SGLT2)


(Mus musculus (Mouse))
BDBM50302603
PNG
((2S,3R,4R,5S)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl...)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2OC(OC)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C21H25ClO6/c1-3-27-15-7-4-12(5-8-15)10-14-11-13(6-9-16(14)22)20-18(24)17(23)19(25)21(26-2)28-20/h4-9,11,17-21,23-25H,3,10H2,1-2H3/t17-,18-,19+,20+,21?/m1/s1
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n/an/a 6.30n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of mouse SGLT2-mediated [14C]alpha-methylglucopyranoside uptake by cell based assay


Citation and Details
More data for this
Ligand-Target Pair
sodium-dependent glucose cotransporter 2 (SGLT2)


(Mus musculus (Mouse))
BDBM109277
PNG
(US8609622, 4)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)C23OC[C@@](CO)(O2)[C@@H](O)[C@H](O)[C@H]3O)cc1F
Show InChI InChI=1S/C22H24ClFO7/c1-2-29-17-6-3-12(8-16(17)24)7-13-9-14(4-5-15(13)23)22-20(28)18(26)19(27)21(10-25,31-22)11-30-22/h3-6,8-9,18-20,25-28H,2,7,10-11H2,1H3/t18-,19-,20+,21+,22?/m0/s1
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US Patent
n/an/a 6.35n/an/an/an/an/an/a



Shanghai Hengrui Pharmaceutical Co., Ltd.; Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
Inhibitory activity of the compounds using SGLT1 and SGLT2.


US Patent US8609622 (2013)

More data for this
Ligand-Target Pair
sodium-dependent glucose cotransporter 2 (SGLT2)


(Mus musculus (Mouse))
BDBM109277
PNG
(US8609622, 4)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)C23OC[C@@](CO)(O2)[C@@H](O)[C@H](O)[C@H]3O)cc1F
Show InChI InChI=1S/C22H24ClFO7/c1-2-29-17-6-3-12(8-16(17)24)7-13-9-14(4-5-15(13)23)22-20(28)18(26)19(27)21(10-25,31-22)11-30-22/h3-6,8-9,18-20,25-28H,2,7,10-11H2,1H3/t18-,19-,20+,21+,22?/m0/s1
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US Patent
n/an/a 6.92n/an/an/an/an/an/a



Shanghai Hengrui Pharmaceutical Co., Ltd.; Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
Inhibitory activity of the compounds using SGLT1 and SGLT2.


US Patent US8609622 (2013)

More data for this
Ligand-Target Pair
Low affinity sodium-glucose cotransporter


(Homo sapiens)
BDBM50313368
PNG
((6S,7R,8R,9S)-6-(3-(4-methoxybenzyl)-4-methylpheny...)
Show SMILES COc1ccc(Cc2cc(ccc2C)[C@@H]2OC3(COC3)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C22H26O6/c1-13-3-6-15(10-16(13)9-14-4-7-17(26-2)8-5-14)20-18(23)19(24)21(25)22(28-20)11-27-12-22/h3-8,10,18-21,23-25H,9,11-12H2,1-2H3/t18-,19-,20+,21+/m1/s1
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n/an/a 6.98n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of methyl alpha-D-glucopyranoside uptake after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
sodium-dependent glucose cotransporter 2 (SGLT2)


(Mus musculus (Mouse))
BDBM50302603
PNG
((2S,3R,4R,5S)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl...)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2OC(OC)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C21H25ClO6/c1-3-27-15-7-4-12(5-8-15)10-14-11-13(6-9-16(14)22)20-18(24)17(23)19(25)21(26-2)28-20/h4-9,11,17-21,23-25H,3,10H2,1-2H3/t17-,18-,19+,20+,21?/m1/s1
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n/an/a 7.10n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of mouse SGLT2-mediated [14C]alpha-methylglucopyranoside uptake by cell based assay


Citation and Details
More data for this
Ligand-Target Pair
sodium-dependent glucose cotransporter 2 (SGLT2)


(Mus musculus (Mouse))
BDBM50302603
PNG
((2S,3R,4R,5S)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl...)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2OC(OC)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C21H25ClO6/c1-3-27-15-7-4-12(5-8-15)10-14-11-13(6-9-16(14)22)20-18(24)17(23)19(25)21(26-2)28-20/h4-9,11,17-21,23-25H,3,10H2,1-2H3/t17-,18-,19+,20+,21?/m1/s1
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n/an/a 7.10n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of mouse SGLT2-mediated [14C]alpha-methylglucopyranoside uptake by cell based assay


Citation and Details
More data for this
Ligand-Target Pair
sodium-dependent glucose cotransporter 2 (SGLT2)


(Mus musculus (Mouse))
BDBM50302617
PNG
((2S,3R,4R,5S)-2-[4-Chloro-3-(4-hydroxy-benzyl)-phe...)
Show SMILES COC1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(O)cc2)c1
Show InChI InChI=1S/C19H21ClO6/c1-25-19-17(24)15(22)16(23)18(26-19)11-4-7-14(20)12(9-11)8-10-2-5-13(21)6-3-10/h2-7,9,15-19,21-24H,8H2,1H3/t15-,16-,17+,18+,19?/m1/s1
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n/an/a 8n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of mouse SGLT2-mediated [14C]alpha-methylglucopyranoside uptake by cell based assay


Citation and Details
More data for this
Ligand-Target Pair
sodium-dependent glucose cotransporter 2 (SGLT2)


(Mus musculus (Mouse))
BDBM109276
PNG
(US8609622, 3)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)C23OC[C@@](CO)(O2)[C@@H](O)[C@H](O)[C@H]3O)c(F)c1F
Show InChI InChI=1S/C22H23ClF2O7/c1-2-30-15-6-3-11(16(24)17(15)25)7-12-8-13(4-5-14(12)23)22-20(29)18(27)19(28)21(9-26,32-22)10-31-22/h3-6,8,18-20,26-29H,2,7,9-10H2,1H3/t18-,19-,20+,21+,22?/m0/s1
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US Patent
n/an/a 8.08n/an/an/an/an/an/a



Shanghai Hengrui Pharmaceutical Co., Ltd.; Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
Inhibitory activity of the compounds using SGLT1 and SGLT2.


US Patent US8609622 (2013)

More data for this
Ligand-Target Pair
sodium-dependent glucose cotransporter 2 (SGLT2)


(Mus musculus (Mouse))
BDBM109280
PNG
(US8609622, 9)
Show SMILES Cc1ccc(cc1Cc1ccc(s1)-c1ccc(F)cc1)C12OC[C@@](CO)(O1)[C@@H](O)[C@H](O)[C@H]2O
Show InChI InChI=1S/C25H25FO6S/c1-14-2-5-17(25-23(30)21(28)22(29)24(12-27,32-25)13-31-25)10-16(14)11-19-8-9-20(33-19)15-3-6-18(26)7-4-15/h2-10,21-23,27-30H,11-13H2,1H3/t21-,22-,23+,24+,25?/m0/s1
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n/an/a 9.28n/an/an/an/an/an/a



Shanghai Hengrui Pharmaceutical Co., Ltd.; Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
Inhibitory activity of the compounds using SGLT1 and SGLT2.


US Patent US8609622 (2013)

More data for this
Ligand-Target Pair
sodium-dependent glucose cotransporter 2 (SGLT2)


(Mus musculus (Mouse))
BDBM50302616
PNG
((2S,3R,4R,5S)-2-(4-Chloro-3-(4-(2-hydroxyethoxy)be...)
Show SMILES COC1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(OCCO)cc2)c1
Show InChI InChI=1S/C21H25ClO7/c1-27-21-19(26)17(24)18(25)20(29-21)13-4-7-16(22)14(11-13)10-12-2-5-15(6-3-12)28-9-8-23/h2-7,11,17-21,23-26H,8-10H2,1H3/t17-,18-,19+,20+,21?/m1/s1
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n/an/a 9.5n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of mouse SGLT2-mediated [14C]alpha-methylglucopyranoside uptake by cell based assay


Citation and Details
More data for this
Ligand-Target Pair
sodium-dependent glucose cotransporter 2 (SGLT2)


(Mus musculus (Mouse))
BDBM109274
PNG
(US8609622, 1)
Show SMILES OC[C@]12CO[C@](O1)([C@H](O)[C@@H](O)[C@@H]2O)c1ccc(Cl)c(Cc2ccc(OCCOC3CC3)cc2)c1
Show InChI InChI=1S/C25H29ClO8/c26-20-8-3-17(25-23(30)21(28)22(29)24(13-27,34-25)14-33-25)12-16(20)11-15-1-4-18(5-2-15)31-9-10-32-19-6-7-19/h1-5,8,12,19,21-23,27-30H,6-7,9-11,13-14H2/t21-,22-,23+,24+,25+/m0/s1
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n/an/a 9.53n/an/an/an/an/an/a



Shanghai Hengrui Pharmaceutical Co., Ltd.; Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
Inhibitory activity of the compounds using SGLT1 and SGLT2.


US Patent US8609622 (2013)

More data for this
Ligand-Target Pair
Low affinity sodium-glucose cotransporter


(Homo sapiens)
BDBM50351435
PNG
(CHEMBL1819489)
Show SMILES OC[C@H]1C[C@@H](Oc2ccccc2Cc2ccc(cc2)C2CC2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C23H28O5/c24-13-18-12-20(22(26)23(27)21(18)25)28-19-4-2-1-3-17(19)11-14-5-7-15(8-6-14)16-9-10-16/h1-8,16,18,20-27H,9-13H2/t18-,20-,21-,22+,23+/m1/s1
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n/an/a 11n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins


Citation and Details
More data for this
Ligand-Target Pair
sodium-dependent glucose cotransporter 2 (SGLT2)


(Mus musculus (Mouse))
BDBM50302625
PNG
((2S,3R,4R,5S)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl...)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2OC(OC(C)C)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C23H29ClO6/c1-4-28-17-8-5-14(6-9-17)11-16-12-15(7-10-18(16)24)22-20(26)19(25)21(27)23(30-22)29-13(2)3/h5-10,12-13,19-23,25-27H,4,11H2,1-3H3/t19-,20-,21+,22+,23?/m1/s1
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n/an/a 15n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of mouse SGLT2-mediated [14C]alpha-methylglucopyranoside uptake by cell based assay


Citation and Details
More data for this
Ligand-Target Pair
Low affinity sodium-glucose cotransporter


(Homo sapiens)
BDBM20875
PNG
(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Show SMILES OC[C@H]1O[C@@H](Oc2cc(O)cc(O)c2C(=O)CCc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C21H24O10/c22-9-16-18(27)19(28)20(29)21(31-16)30-15-8-12(24)7-14(26)17(15)13(25)6-3-10-1-4-11(23)5-2-10/h1-2,4-5,7-8,16,18-24,26-29H,3,6,9H2/t16-,18-,19+,20-,21-/m1/s1
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n/an/a 16n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins


Citation and Details
More data for this
Ligand-Target Pair
sodium-dependent glucose cotransporter 2 (SGLT2)


(Mus musculus (Mouse))
BDBM50302615
PNG
((2S,3R,4R,5S)-2-{4-Chloro-3-[4-(2-methoxy-ethoxy)-...)
Show SMILES COCCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2OC(OC)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C22H27ClO7/c1-27-9-10-29-16-6-3-13(4-7-16)11-15-12-14(5-8-17(15)23)21-19(25)18(24)20(26)22(28-2)30-21/h3-8,12,18-22,24-26H,9-11H2,1-2H3/t18-,19-,20+,21+,22?/m1/s1
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n/an/a 16n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of mouse SGLT2-mediated [14C]alpha-methylglucopyranoside uptake by cell based assay


Citation and Details
More data for this
Ligand-Target Pair
Low affinity sodium-glucose cotransporter


(Homo sapiens)
BDBM50351439
PNG
(CHEMBL1819492)
Show SMILES CSc1ccc(Cc2ccccc2O[C@@H]2C[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C21H26O5S/c1-27-16-8-6-13(7-9-16)10-14-4-2-3-5-17(14)26-18-11-15(12-22)19(23)21(25)20(18)24/h2-9,15,18-25H,10-12H2,1H3/t15-,18-,19-,20+,21+/m1/s1
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n/an/a 19n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins


Citation and Details
More data for this
Ligand-Target Pair
sodium-dependent glucose cotransporter 2 (SGLT2)


(Mus musculus (Mouse))
BDBM50302624
PNG
((2S,3R,4R,5S)-2-[4-Chloro-3-(4-ethoxy-benzyl)-phen...)
Show SMILES CCOC1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(OCC)cc2)c1
Show InChI InChI=1S/C22H27ClO6/c1-3-27-16-8-5-13(6-9-16)11-15-12-14(7-10-17(15)23)21-19(25)18(24)20(26)22(29-21)28-4-2/h5-10,12,18-22,24-26H,3-4,11H2,1-2H3/t18-,19-,20+,21+,22?/m1/s1
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n/an/a 19n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of mouse SGLT2-mediated [14C]alpha-methylglucopyranoside uptake by cell based assay


Citation and Details
More data for this
Ligand-Target Pair
sodium-dependent glucose cotransporter 2 (SGLT2)


(Mus musculus (Mouse))
BDBM50302609
PNG
((2S,3R,4R,5S)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl...)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2OC(OCCO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C22H27ClO7/c1-2-28-16-6-3-13(4-7-16)11-15-12-14(5-8-17(15)23)21-19(26)18(25)20(27)22(30-21)29-10-9-24/h3-8,12,18-22,24-27H,2,9-11H2,1H3/t18-,19-,20+,21+,22?/m1/s1
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n/an/a 23n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of mouse SGLT2-mediated [14C]alpha-methylglucopyranoside uptake by cell based assay


Citation and Details
More data for this
Ligand-Target Pair
sodium-dependent glucose cotransporter 2 (SGLT2)


(Mus musculus (Mouse))
BDBM50302623
PNG
((2S,3R,4R,5S)-2-(3-(4-Ethoxybenzyl)-4-methylphenyl...)
Show SMILES CCOc1ccc(Cc2cc(ccc2C)[C@@H]2OC(OC)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C22H28O6/c1-4-27-17-9-6-14(7-10-17)11-16-12-15(8-5-13(16)2)21-19(24)18(23)20(25)22(26-3)28-21/h5-10,12,18-25H,4,11H2,1-3H3/t18-,19-,20+,21+,22?/m1/s1
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n/an/a 23n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of mouse SGLT2-mediated [14C]alpha-methylglucopyranoside uptake by cell based assay


Citation and Details
More data for this
Ligand-Target Pair
Low affinity sodium-glucose cotransporter


(Homo sapiens)
BDBM50351432
PNG
(CHEMBL1819486)
Show SMILES CCc1ccc(Cc2ccccc2O[C@@H]2C[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C22H28O5/c1-2-14-7-9-15(10-8-14)11-16-5-3-4-6-18(16)27-19-12-17(13-23)20(24)22(26)21(19)25/h3-10,17,19-26H,2,11-13H2,1H3/t17-,19-,20-,21+,22+/m1/s1
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n/an/a 28n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins


Citation and Details
More data for this
Ligand-Target Pair
Low affinity sodium-glucose cotransporter


(Homo sapiens)
BDBM50351436
PNG
(CHEMBL1819490)
Show SMILES OC[C@H]1C[C@@H](Oc2ccccc2Cc2ccc(C=C)cc2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C22H26O5/c1-2-14-7-9-15(10-8-14)11-16-5-3-4-6-18(16)27-19-12-17(13-23)20(24)22(26)21(19)25/h2-10,17,19-26H,1,11-13H2/t17-,19-,20-,21+,22+/m1/s1
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n/an/a 29n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins


Citation and Details
More data for this
Ligand-Target Pair
Low affinity sodium-glucose cotransporter


(Homo sapiens)
BDBM50351437
PNG
(CHEMBL1819491)
Show SMILES COc1ccc(Cc2ccccc2O[C@@H]2C[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C21H26O6/c1-26-16-8-6-13(7-9-16)10-14-4-2-3-5-17(14)27-18-11-15(12-22)19(23)21(25)20(18)24/h2-9,15,18-25H,10-12H2,1H3/t15-,18-,19-,20+,21+/m1/s1
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n/an/a 42n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins


Citation and Details
More data for this
Ligand-Target Pair
Low affinity sodium-glucose cotransporter


(Homo sapiens)
BDBM50342886
PNG
((1S,2S,3S,4S,5S)-5-[4-Chloro-3-(4-methoxybenzyl)-p...)
Show SMILES COc1ccc(Cc2cc(ccc2Cl)[C@]23OC[C@](CO)(O2)[C@@H](O)[C@H](O)[C@@H]3O)cc1
Show InChI InChI=1S/C21H23ClO7/c1-27-15-5-2-12(3-6-15)8-13-9-14(4-7-16(13)22)21-19(26)17(24)18(25)20(10-23,29-21)11-28-21/h2-7,9,17-19,23-26H,8,10-11H2,1H3/t17-,18-,19-,20-,21-/m0/s1
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n/an/a 43.1n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of methyl alpha-D-glucopyranoside uptake after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
sodium-dependent glucose cotransporter 2 (SGLT2)


(Mus musculus (Mouse))
BDBM50302619
PNG
(CHEMBL567572 | [2-Chloro-5-((2S,3R,4R,5S,6S)-3,4,5...)
Show SMILES CCOc1ccc(cc1)C(=O)c1cc(ccc1Cl)[C@@H]1O[C@@H](OC)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C21H23ClO7/c1-3-28-13-7-4-11(5-8-13)16(23)14-10-12(6-9-15(14)22)20-18(25)17(24)19(26)21(27-2)29-20/h4-10,17-21,24-26H,3H2,1-2H3/t17-,18-,19+,20+,21-/m1/s1
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n/an/a 57n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of mouse SGLT2-mediated [14C]alpha-methylglucopyranoside uptake by cell based assay


Citation and Details
More data for this
Ligand-Target Pair
Low affinity sodium-glucose cotransporter


(Homo sapiens)
BDBM50351431
PNG
(CHEMBL1819485)
Show SMILES Cc1ccc(Cc2ccccc2O[C@@H]2C[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C21H26O5/c1-13-6-8-14(9-7-13)10-15-4-2-3-5-17(15)26-18-11-16(12-22)19(23)21(25)20(18)24/h2-9,16,18-25H,10-12H2,1H3/t16-,18-,19-,20+,21+/m1/s1
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n/an/a 59n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins


Citation and Details
More data for this
Ligand-Target Pair
Low affinity sodium-glucose cotransporter


(Homo sapiens)
BDBM50345019
PNG
((2R,3S,4R,5R,6S)-2-(hydroxymethyl)-6-(3-(4-(pent-2...)
Show SMILES CC\C=C\COc1ccc(Cc2cccc(c2)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C24H30O6/c1-2-3-4-12-29-19-10-8-16(9-11-19)13-17-6-5-7-18(14-17)24-23(28)22(27)21(26)20(15-25)30-24/h3-11,14,20-28H,2,12-13,15H2,1H3/b4-3+/t20-,21-,22+,23-,24+/m1/s1
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n/an/a 59.5n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells using methyl-alpha-D-glucopyranoside by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
sodium-dependent glucose cotransporter 2 (SGLT2)


(Mus musculus (Mouse))
BDBM50302613
PNG
((2S,3R,4R,5S)-2-(4-Chloro-3-(4-(thiazol-2-yloxy)be...)
Show SMILES COC1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(Oc3nccs3)cc2)c1
Show InChI InChI=1S/C22H22ClNO6S/c1-28-21-19(27)17(25)18(26)20(30-21)13-4-7-16(23)14(11-13)10-12-2-5-15(6-3-12)29-22-24-8-9-31-22/h2-9,11,17-21,25-27H,10H2,1H3/t17-,18-,19+,20+,21?/m1/s1
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n/an/a 60n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of mouse SGLT2-mediated [14C]alpha-methylglucopyranoside uptake by cell based assay


Citation and Details
More data for this
Ligand-Target Pair
Low affinity sodium-glucose cotransporter


(Homo sapiens)
BDBM50345022
PNG
((2R,3S,4R,5R,6S)-2-Hydroxymethyl-6-(15-oxa-tricycl...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc2CCCCCCOc3ccc(Cc2c1)cc3
Show InChI InChI=1S/C25H32O6/c26-15-21-22(27)23(28)24(29)25(31-21)18-9-8-17-5-3-1-2-4-12-30-20-10-6-16(7-11-20)13-19(17)14-18/h6-11,14,21-29H,1-5,12-13,15H2/t21-,22-,23+,24-,25+/m1/s1
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n/an/a 81.9n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells using methyl-alpha-D-glucopyranoside by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Low affinity sodium-glucose cotransporter


(Homo sapiens)
BDBM50345020
PNG
((2R,3S,4R,5R,6S)-2-Hydroxymethyl-6-(15-oxa-tricycl...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc2CCC\C=C\COc3ccc(Cc2c1)cc3
Show InChI InChI=1S/C25H30O6/c26-15-21-22(27)23(28)24(29)25(31-21)18-9-8-17-5-3-1-2-4-12-30-20-10-6-16(7-11-20)13-19(17)14-18/h2,4,6-11,14,21-29H,1,3,5,12-13,15H2/b4-2+/t21-,22-,23+,24-,25+/m1/s1
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n/an/a 89.6n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells using methyl-alpha-D-glucopyranoside by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Low affinity sodium-glucose cotransporter


(Homo sapiens)
BDBM50342884
PNG
((1S,2S,3S,4S,5S)-5-[4-Chloro-3-(4-ethoxybenzyl)-ph...)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@]23OC[C@](CO)(O2)[C@@H](O)[C@H](O)[C@@H]3O)cc1
Show InChI InChI=1S/C22H25ClO7/c1-2-28-16-6-3-13(4-7-16)9-14-10-15(5-8-17(14)23)22-20(27)18(25)19(26)21(11-24,30-22)12-29-22/h3-8,10,18-20,24-27H,2,9,11-12H2,1H3/t18-,19-,20-,21-,22-/m0/s1
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n/an/a 89.9n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of methyl alpha-D-glucopyranoside uptake after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
sodium-dependent glucose cotransporter 2 (SGLT2)


(Mus musculus (Mouse))
BDBM50302614
PNG
((2R,3S,4S,5R)-2-(4-Chloro-3-(4-((S)-1-methylpyrrol...)
Show SMILES COC1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(O[C@H]3CCN(C)C3)cc2)c1
Show InChI InChI=1S/C24H30ClNO6/c1-26-10-9-18(13-26)31-17-6-3-14(4-7-17)11-16-12-15(5-8-19(16)25)23-21(28)20(27)22(29)24(30-2)32-23/h3-8,12,18,20-24,27-29H,9-11,13H2,1-2H3/t18-,20+,21+,22-,23-,24?/m0/s1
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n/an/a 92n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of mouse SGLT2-mediated [14C]alpha-methylglucopyranoside uptake by cell based assay


Citation and Details
More data for this
Ligand-Target Pair
Low affinity sodium-glucose cotransporter


(Homo sapiens)
BDBM50345023
PNG
((2R,3S,4R,5R,6S)-2-Hydroxymethyl-6-(16-oxa-tricycl...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc2CCCCCCCOc3ccc(Cc2c1)cc3
Show InChI InChI=1S/C26H34O6/c27-16-22-23(28)24(29)25(30)26(32-22)19-10-9-18-6-4-2-1-3-5-13-31-21-11-7-17(8-12-21)14-20(18)15-19/h7-12,15,22-30H,1-6,13-14,16H2/t22-,23-,24+,25-,26+/m1/s1
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n/an/a 99.7n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells using methyl-alpha-D-glucopyranoside by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
sodium-dependent glucose cotransporter 2 (SGLT2)


(Mus musculus (Mouse))
BDBM50302621
PNG
((2S,3R,4R,5S)-2-(4-Chloro-3-(4-methoxyphenylthio)p...)
Show SMILES COC1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Sc2ccc(OC)cc2)c1
Show InChI InChI=1S/C19H21ClO6S/c1-24-11-4-6-12(7-5-11)27-14-9-10(3-8-13(14)20)18-16(22)15(21)17(23)19(25-2)26-18/h3-9,15-19,21-23H,1-2H3/t15-,16-,17+,18+,19?/m1/s1
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n/an/a 100n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of mouse SGLT2-mediated [14C]alpha-methylglucopyranoside uptake by cell based assay


Citation and Details
More data for this
Ligand-Target Pair
sodium-dependent glucose cotransporter 2 (SGLT2)


(Mus musculus (Mouse))
BDBM50302604
PNG
((3S,4R,5R,6S)-6-[4-Chloro-3-(4-ethoxy-benzyl)-phen...)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2OC(O)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C20H23ClO6/c1-2-26-14-6-3-11(4-7-14)9-13-10-12(5-8-15(13)21)19-17(23)16(22)18(24)20(25)27-19/h3-8,10,16-20,22-25H,2,9H2,1H3/t16-,17-,18+,19+,20?/m1/s1
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n/an/a 100n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of mouse SGLT2-mediated [14C]alpha-methylglucopyranoside uptake by cell based assay


Citation and Details
More data for this
Ligand-Target Pair
Low affinity sodium-glucose cotransporter


(Homo sapiens)
BDBM50345021
PNG
((2R,3S,4R,5R,6S)-2-Hydroxymethyl-6-(16-oxa-tricycl...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc2CCCC\C=C\COc3ccc(Cc2c1)cc3
Show InChI InChI=1S/C26H32O6/c27-16-22-23(28)24(29)25(30)26(32-22)19-10-9-18-6-4-2-1-3-5-13-31-21-11-7-17(8-12-21)14-20(18)15-19/h3,5,7-12,15,22-30H,1-2,4,6,13-14,16H2/b5-3+/t22-,23-,24+,25-,26+/m1/s1
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n/an/a 103n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells using methyl-alpha-D-glucopyranoside by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Low affinity sodium-glucose cotransporter


(Homo sapiens)
BDBM50351438
PNG
(CHEMBL1817688)
Show SMILES CCOc1ccc(Cc2ccccc2O[C@@H]2C[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C22H28O6/c1-2-27-17-9-7-14(8-10-17)11-15-5-3-4-6-18(15)28-19-12-16(13-23)20(24)22(26)21(19)25/h3-10,16,19-26H,2,11-13H2,1H3/t16-,19-,20-,21+,22+/m1/s1
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n/an/a 110n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins


Citation and Details
More data for this
Ligand-Target Pair
Low affinity sodium-glucose cotransporter


(Homo sapiens)
BDBM50351443
PNG
(CHEMBL1819496)
Show SMILES OC[C@H]1C[C@@H](Oc2ccccc2Cc2ccc(cc2)C(F)(F)F)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C21H23F3O5/c22-21(23,24)15-7-5-12(6-8-15)9-13-3-1-2-4-16(13)29-17-10-14(11-25)18(26)20(28)19(17)27/h1-8,14,17-20,25-28H,9-11H2/t14-,17-,18-,19+,20+/m1/s1
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n/an/a 120n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins


Citation and Details
More data for this
Ligand-Target Pair
Low affinity sodium-glucose cotransporter


(Homo sapiens)
BDBM50351433
PNG
(CHEMBL1819487)
Show SMILES CCCc1ccc(Cc2ccccc2O[C@@H]2C[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C23H30O5/c1-2-5-15-8-10-16(11-9-15)12-17-6-3-4-7-19(17)28-20-13-18(14-24)21(25)23(27)22(20)26/h3-4,6-11,18,20-27H,2,5,12-14H2,1H3/t18-,20-,21-,22+,23+/m1/s1
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n/an/a 120n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins


Citation and Details
More data for this
Ligand-Target Pair
Low affinity sodium-glucose cotransporter


(Homo sapiens)
BDBM50351434
PNG
(CHEMBL1819488)
Show SMILES CC(C)c1ccc(Cc2ccccc2O[C@@H]2C[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C23H30O5/c1-14(2)16-9-7-15(8-10-16)11-17-5-3-4-6-19(17)28-20-12-18(13-24)21(25)23(27)22(20)26/h3-10,14,18,20-27H,11-13H2,1-2H3/t18-,20-,21-,22+,23+/m1/s1
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n/an/a 150n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins


Citation and Details
More data for this
Ligand-Target Pair
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