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Compile Data Set for Download or QSAR

Found 136 hits Enz. Inhib. hit(s) with Target = 'Lysine-specific demethylase 4A'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50150907
PNG
(CHEMBL3774665)
UniProtKB/SwissProt

antibodypedia
GoogleScholar
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PC cid
PC sid
UniChem
AffyNet 
n/an/a 109n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50150908
PNG
(CHEMBL3775814)
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
n/an/a 118n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50150881
PNG
(CHEMBL3775545)
UniProtKB/SwissProt

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n/an/a 123n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50150823
PNG
(CHEMBL3775899)
UniProtKB/SwissProt

antibodypedia
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n/an/a 126n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50150871
PNG
(CHEMBL3775451)
UniProtKB/SwissProt

antibodypedia
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n/an/a 136n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50150874
PNG
(CHEMBL3775977)
UniProtKB/SwissProt

antibodypedia
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UniChem

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n/an/a 138n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50150939
PNG
(CHEMBL3775668)
UniProtKB/SwissProt

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n/an/a 143n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50150827
PNG
(CHEMBL3774940)
UniProtKB/SwissProt

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n/an/a 144n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50150938
PNG
(CHEMBL3775277)
UniProtKB/SwissProt

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n/an/a 145n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50150825
PNG
(CHEMBL3775040)
UniProtKB/SwissProt

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n/an/a 147n/an/an/an/an/an/a


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Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50150826
PNG
(CHEMBL3775516)
UniProtKB/SwissProt

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n/an/a 158n/an/an/an/an/an/a


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Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50150876
PNG
(CHEMBL3775953)
UniProtKB/SwissProt

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Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50150824
PNG
(CHEMBL3774392)
UniProtKB/SwissProt

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n/an/a 181n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50150813
PNG
(CHEMBL3774692)
UniProtKB/SwissProt

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n/an/a 200n/an/an/an/an/an/a


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Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50150801
PNG
(CHEMBL3775362)
UniProtKB/SwissProt

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n/an/a 300n/an/an/an/an/an/a


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Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50150960
PNG
(CHEMBL3775145)
UniProtKB/SwissProt

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n/an/a 390n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50149925
PNG
(CHEMBL3770740)
Show SMILES NS(=O)(=O)c1ccccc1-c1ccc(cc1)C(=O)NC(CC(=O)Nc1ccc(Br)cn1)C(=O)N1CCCCCC1
Show InChI InChI=1S/C28H30BrN5O5S/c29-21-13-14-25(31-18-21)33-26(35)17-23(28(37)34-15-5-1-2-6-16-34)32-27(36)20-11-9-19(10-12-20)22-7-3-4-8-24(22)40(30,38)39/h3-4,7-14,18,23H,1-2,5-6,15-17H2,(H,32,36)(H2,30,38,39)(H,31,33,35)
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Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50150909
PNG
(CHEMBL3775823)
UniProtKB/SwissProt

antibodypedia
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n/an/a 411n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50150919
PNG
(CHEMBL3774457)
UniProtKB/SwissProt

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n/an/a 456n/an/an/an/an/an/a


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Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50122002
PNG
(CHEMBL1383671)
Show SMILES Nc1cnccc1C(O)=O
Show InChI InChI=1S/C6H6N2O2/c7-5-3-8-2-1-4(5)6(9)10/h1-3H,7H2,(H,9,10)
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Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50150828
PNG
(CHEMBL3775465)
UniProtKB/SwissProt

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n/an/a 540n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50150821
PNG
(CHEMBL3775135)
UniProtKB/SwissProt

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n/an/a 600n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM191598
PNG
(2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-ox...)
Show SMILES CCN(CCN(C)C)C(=O)CNCc1cc(ccn1)C(O)=O
Show InChI InChI=1S/C15H24N4O3/c1-4-19(8-7-18(2)3)14(20)11-16-10-13-9-12(15(21)22)5-6-17-13/h5-6,9,16H,4,7-8,10-11H2,1-3H3,(H,21,22)
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n/an/a 600n/an/an/an/an/an/a



University of Oxford





Cell Chem Biol 24: 371-380 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50150872
PNG
(CHEMBL3775956)
UniProtKB/SwissProt

antibodypedia
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PC cid
PC sid
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AffyNet 
n/an/a 600n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM195612
PNG
(GSK467)
Show SMILES O=c1[nH]c(Oc2cnn(Cc3ccccc3)c2)nc2cnccc12
Show InChI InChI=1S/C17H13N5O2/c23-16-14-6-7-18-9-15(14)20-17(21-16)24-13-8-19-22(11-13)10-12-4-2-1-3-5-12/h1-9,11H,10H2,(H,20,21,23)
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n/an/a 631n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50149917
PNG
(CHEMBL3771198)
Show SMILES COC(=O)C(CC(=O)Nc1ccc(Br)cn1)NC(=O)c1ccc(cc1)-c1ccccc1S(N)(=O)=O
Show InChI InChI=1S/C23H21BrN4O6S/c1-34-23(31)18(12-21(29)28-20-11-10-16(24)13-26-20)27-22(30)15-8-6-14(7-9-15)17-4-2-3-5-19(17)35(25,32)33/h2-11,13,18H,12H2,1H3,(H,27,30)(H2,25,32,33)(H,26,28,29)
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Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50150820
PNG
(CHEMBL3774701)
UniProtKB/SwissProt

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n/an/a 660n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50150873
PNG
(CHEMBL3775130)
UniProtKB/SwissProt

antibodypedia
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PC cid
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AffyNet 
n/an/a 770n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50149920
PNG
(CHEMBL3769724)
Show SMILES CN(C)Cc1nccn1-c1ccc(cc1)C(=O)N[C@H](CC(=O)Nc1ccc(Br)cn1)C(=O)N1CCCCC1
Show InChI InChI=1S/C27H32BrN7O3/c1-33(2)18-24-29-12-15-35(24)21-9-6-19(7-10-21)26(37)31-22(27(38)34-13-4-3-5-14-34)16-25(36)32-23-11-8-20(28)17-30-23/h6-12,15,17,22H,3-5,13-14,16,18H2,1-2H3,(H,31,37)(H,30,32,36)/t22-/m1/s1
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n/an/a 794n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50324535
PNG
(3-{[9-(Dimethylamino)nonanoyl](hydroxy)amino}propa...)
Show SMILES CN(C)CCCCCCCCC(=O)N(O)CCC(O)=O
Show InChI InChI=1S/C14H28N2O4/c1-15(2)11-8-6-4-3-5-7-9-13(17)16(20)12-10-14(18)19/h20H,3-12H2,1-2H3,(H,18,19)
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n/an/a 800n/an/an/an/an/an/a



Kyoto Prefectural University of Medicine

Curated by ChEMBL


Assay Description
Inhibition of KDM4A (unknown origin) using H3K9me3 peptide and 2-oxoglutarate as substrate after 1 hr by FDH-coupled assay


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50150822
PNG
(CHEMBL3774922)
UniProtKB/SwissProt

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n/an/a 880n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50150811
PNG
(CHEMBL3775933)
UniProtKB/SwissProt

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n/an/a 900n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50150945
PNG
(CHEMBL3774747)
UniProtKB/SwissProt

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n/an/a 900n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50150800
PNG
(CHEMBL3775095)
UniProtKB/SwissProt

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n/an/a 950n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50150955
PNG
(CHEMBL3774710)
UniProtKB/SwissProt

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n/an/a 1.40E+3n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50149924
PNG
(CHEMBL3769511)
Show SMILES NS(=O)(=O)c1ccccc1-c1ccc(NC(=O)CCNC(=O)c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C22H20ClN3O4S/c23-17-9-5-16(6-10-17)22(28)25-14-13-21(27)26-18-11-7-15(8-12-18)19-3-1-2-4-20(19)31(24,29)30/h1-12H,13-14H2,(H,25,28)(H,26,27)(H2,24,29,30)
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n/an/a 1.59E+3n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50133290
PNG
(CHEMBL3634952)
Show SMILES CN1CCN(CC1)C(=O)c1ccc2c(ccc(O)c2n1)C(O)=O
Show InChI InChI=1S/C16H17N3O4/c1-18-6-8-19(9-7-18)15(21)12-4-2-10-11(16(22)23)3-5-13(20)14(10)17-12/h2-5,20H,6-9H2,1H3,(H,22,23)
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n/an/a 1.60E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human JMJD2A using biotinylated histone H3 as substrate by AlphaScreen assay


Eur J Med Chem 105: 145-55 (2015)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50361473
PNG
(CHEMBL1435274)
Show SMILES OC(=O)c1ccnc2c(O)cccc12
Show InChI InChI=1S/C10H7NO3/c12-8-3-1-2-6-7(10(13)14)4-5-11-9(6)8/h1-5,12H,(H,13,14)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Kyoto Prefectural University of Medicine

Curated by ChEMBL


Assay Description
Inhibition of KDM4A


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50150025
PNG
(CHEMBL3770256)
UniProtKB/SwissProt

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n/an/a 1.70E+3n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50396018
PNG
(CHEMBL1230640)
Show SMILES OC(=O)c1ccc(O)c2ncccc12
Show InChI InChI=1S/C10H7NO3/c12-8-4-3-7(10(13)14)6-2-1-5-11-9(6)8/h1-5,12H,(H,13,14)
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n/an/a 1.70E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of JMJD2A catalytic domain by mass spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50150959
PNG
(CHEMBL3775500)
UniProtKB/SwissProt

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n/an/a 1.80E+3n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50133292
PNG
(CHEMBL3634950)
Show SMILES CCN(CC)C(=O)c1ccc2c(ccc(O)c2n1)C(O)=O
Show InChI InChI=1S/C15H16N2O4/c1-3-17(4-2)14(19)11-7-5-9-10(15(20)21)6-8-12(18)13(9)16-11/h5-8,18H,3-4H2,1-2H3,(H,20,21)
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n/an/a 1.80E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human JMJD2A using biotinylated histone H3 as substrate by AlphaScreen assay


Eur J Med Chem 105: 145-55 (2015)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50324529
PNG
(3-({9-[Benzyl(methyl)]amino}nonanoyl(hydroxy)amino...)
Show SMILES CN(CCCCCCCCC(=O)N(O)CCC(O)=O)Cc1ccccc1
Show InChI InChI=1S/C20H32N2O4/c1-21(17-18-11-7-6-8-12-18)15-10-5-3-2-4-9-13-19(23)22(26)16-14-20(24)25/h6-8,11-12,26H,2-5,9-10,13-17H2,1H3,(H,24,25)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Nagoya City University

Curated by ChEMBL


Assay Description
Inhibition of recombinant His-tagged JMJD2A expressed in Escherichia coli Rosetta 2 (DE3) pLysS cells by formaldehyde dehydrogenase-coupled assay


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50436039
PNG
(CHEMBL2392185)
Show SMILES NCc1ccc(CNCCCCN(O)C(=O)\C=C\C(O)=O)cc1
Show InChI InChI=1S/C16H23N3O4/c17-11-13-3-5-14(6-4-13)12-18-9-1-2-10-19(23)15(20)7-8-16(21)22/h3-8,18,23H,1-2,9-12,17H2,(H,21,22)/b8-7+
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n/an/a 2.40E+3n/an/an/an/an/an/a



University of Colorado

Curated by ChEMBL


Assay Description
Inhibition of JMJD2A (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50133269
PNG
(CHEMBL3634932)
Show SMILES OC(=O)c1ccc(O)c2nc(ccc12)C(=O)Nc1ccccn1
Show InChI InChI=1S/C16H11N3O4/c20-12-7-5-10(16(22)23)9-4-6-11(18-14(9)12)15(21)19-13-3-1-2-8-17-13/h1-8,20H,(H,22,23)(H,17,19,21)
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n/an/a 2.80E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human JMJD2A using biotinylated histone H3 as substrate by AlphaScreen assay


Eur J Med Chem 105: 145-55 (2015)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50324535
PNG
(3-{[9-(Dimethylamino)nonanoyl](hydroxy)amino}propa...)
Show SMILES CN(C)CCCCCCCCC(=O)N(O)CCC(O)=O
Show InChI InChI=1S/C14H28N2O4/c1-15(2)11-8-6-4-3-5-7-9-13(17)16(20)12-10-14(18)19/h20H,3-12H2,1-2H3,(H,18,19)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Kyoto Prefectural University of Medicine

Curated by ChEMBL


Assay Description
Inhibition of KDM4A


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50324535
PNG
(3-{[9-(Dimethylamino)nonanoyl](hydroxy)amino}propa...)
Show SMILES CN(C)CCCCCCCCC(=O)N(O)CCC(O)=O
Show InChI InChI=1S/C14H28N2O4/c1-15(2)11-8-6-4-3-5-7-9-13(17)16(20)12-10-14(18)19/h20H,3-12H2,1-2H3,(H,18,19)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Nagoya City University

Curated by ChEMBL


Assay Description
Inhibition of recombinant His-tagged JMJD2A expressed in Escherichia coli Rosetta 2 (DE3) pLysS cells by formaldehyde dehydrogenase-coupled assay


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50396018
PNG
(CHEMBL1230640)
Show SMILES OC(=O)c1ccc(O)c2ncccc12
Show InChI InChI=1S/C10H7NO3/c12-8-4-3-7(10(13)14)6-2-1-5-11-9(6)8/h1-5,12H,(H,13,14)
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n/an/a 3.20E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human JMJD2A using biotinylated histone H3 as substrate by AlphaScreen assay


Eur J Med Chem 105: 145-55 (2015)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50324528
PNG
(3-({9-[Butyl(methyl)]amino}nonanoyl(hydroxy)amino)...)
Show SMILES CCCCN(C)CCCCCCCCC(=O)N(O)CCC(O)=O
Show InChI InChI=1S/C17H34N2O4/c1-3-4-13-18(2)14-10-8-6-5-7-9-11-16(20)19(23)15-12-17(21)22/h23H,3-15H2,1-2H3,(H,21,22)
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n/an/a 3.20E+3n/an/an/an/an/an/a



Nagoya City University

Curated by ChEMBL


Assay Description
Inhibition of recombinant His-tagged JMJD2A expressed in Escherichia coli Rosetta 2 (DE3) pLysS cells by formaldehyde dehydrogenase-coupled assay


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A (KDM4A)


(Homo sapiens (Human))
BDBM50361475
PNG
(CHEMBL1938900)
Show SMILES ON(CCCCNCc1ccc(COC(=O)Nc2cccc3ccccc23)cc1)C(=O)C=CC(O)=O
Show InChI InChI=1S/C27H29N3O6/c31-25(14-15-26(32)33)30(35)17-4-3-16-28-18-20-10-12-21(13-11-20)19-36-27(34)29-24-9-5-7-22-6-1-2-8-23(22)24/h1-2,5-15,28,35H,3-4,16-19H2,(H,29,34)(H,32,33)
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n/an/a 3.30E+3n/an/an/an/an/an/a



University of Colorado

Curated by ChEMBL


Assay Description
Inhibition of JMJD2A (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
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