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Found 236 hits Enz. Inhib. hit(s) with Target = 'Lysine-specific demethylase 4C'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific demethylase 4C (KDM4C)


(Homo sapiens (Human))
BDBM191598
PNG
(2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-ox...)
Show SMILES CCN(CCN(C)C)C(=O)CNCc1cc(ccn1)C(O)=O
Show InChI InChI=1S/C15H24N4O3/c1-4-19(8-7-18(2)3)14(20)11-16-10-13-9-12(15(21)22)5-6-17-13/h5-6,9,16H,4,7-8,10-11H2,1-3H3,(H,21,22)
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n/an/a 170n/an/an/an/an/an/a



University of Oxford





Cell Chem Biol 24: 371-380 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (KDM4C)


(Homo sapiens (Human))
BDBM191598
PNG
(2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-ox...)
Show SMILES CCN(CCN(C)C)C(=O)CNCc1cc(ccn1)C(O)=O
Show InChI InChI=1S/C15H24N4O3/c1-4-19(8-7-18(2)3)14(20)11-16-10-13-9-12(15(21)22)5-6-17-13/h5-6,9,16H,4,7-8,10-11H2,1-3H3,(H,21,22)
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University of Oxford





Cell Chem Biol 24: 371-380 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (KDM4C)


(Homo sapiens (Human))
BDBM50149926
PNG
(CHEMBL3770723)
Show SMILES NS(=O)(=O)c1ccccc1-c1ccc(cc1)C(=O)NCCC(=O)Nc1ccc(Cl)cn1
Show InChI InChI=1S/C21H19ClN4O4S/c22-16-9-10-19(25-13-16)26-20(27)11-12-24-21(28)15-7-5-14(6-8-15)17-3-1-2-4-18(17)31(23,29)30/h1-10,13H,11-12H2,(H,24,28)(H2,23,29,30)(H,25,26,27)
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Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (KDM4C)


(Homo sapiens (Human))
BDBM191598
PNG
(2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-ox...)
Show SMILES CCN(CCN(C)C)C(=O)CNCc1cc(ccn1)C(O)=O
Show InChI InChI=1S/C15H24N4O3/c1-4-19(8-7-18(2)3)14(20)11-16-10-13-9-12(15(21)22)5-6-17-13/h5-6,9,16H,4,7-8,10-11H2,1-3H3,(H,21,22)
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n/an/a 210n/an/an/an/an/an/a



University of Oxford



Assay Description
The demethylase AlphaScreen assay was performed in 384-well plate format using white proxiplates (PerkinElmer), and transfer of compound (100 nl) was...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (KDM4C)


(Homo sapiens (Human))
BDBM50149916
PNG
(CHEMBL3769522)
Show SMILES NS(=O)(=O)c1ccccc1-c1ccc(cc1)C(=O)NC(CC(=O)Nc1ccc(Br)cn1)C(O)=O
Show InChI InChI=1S/C22H19BrN4O6S/c23-15-9-10-19(25-12-15)27-20(28)11-17(22(30)31)26-21(29)14-7-5-13(6-8-14)16-3-1-2-4-18(16)34(24,32)33/h1-10,12,17H,11H2,(H,26,29)(H,30,31)(H2,24,32,33)(H,25,27,28)
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More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM50149925
PNG
(CHEMBL3770740)
Show SMILES NS(=O)(=O)c1ccccc1-c1ccc(cc1)C(=O)NC(CC(=O)Nc1ccc(Br)cn1)C(=O)N1CCCCCC1
Show InChI InChI=1S/C28H30BrN5O5S/c29-21-13-14-25(31-18-21)33-26(35)17-23(28(37)34-15-5-1-2-6-16-34)32-27(36)20-11-9-19(10-12-20)22-7-3-4-8-24(22)40(30,38)39/h3-4,7-14,18,23H,1-2,5-6,15-17H2,(H,32,36)(H2,30,38,39)(H,31,33,35)
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More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (KDM4C)


(Homo sapiens (Human))
BDBM50149919
PNG
(CHEMBL3769744)
Show SMILES COCCN(C)Cc1ccccc1-c1ccc(cc1)C(=O)N[C@@H](CC(=O)Nc1ccc(Cl)cn1)C(=O)N1CCCCC1
Show InChI InChI=1S/C32H38ClN5O4/c1-37(18-19-42-2)22-25-8-4-5-9-27(25)23-10-12-24(13-11-23)31(40)35-28(32(41)38-16-6-3-7-17-38)20-30(39)36-29-15-14-26(33)21-34-29/h4-5,8-15,21,28H,3,6-7,16-20,22H2,1-2H3,(H,35,40)(H,34,36,39)/t28-/m0/s1
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Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (KDM4C)


(Homo sapiens (Human))
BDBM50149922
PNG
(CHEMBL3769647)
Show SMILES CN(C)C(=N)c1ccc(cc1)C(=O)N[C@H](CC(=O)Nc1ccc(Br)cn1)C(=O)N1CCCCC1
Show InChI InChI=1S/C24H29BrN6O3/c1-30(2)22(26)16-6-8-17(9-7-16)23(33)28-19(24(34)31-12-4-3-5-13-31)14-21(32)29-20-11-10-18(25)15-27-20/h6-11,15,19,26H,3-5,12-14H2,1-2H3,(H,28,33)(H,27,29,32)/t19-/m1/s1
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Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (KDM4C)


(Homo sapiens (Human))
BDBM50149923
PNG
(CHEMBL3770916)
Show SMILES CN(C)Cc1ccccc1-c1ccc(cc1)C(=O)N[C@H](CC(=O)Nc1ccc(Br)cn1)C(=O)N1CCCCC1
Show InChI InChI=1S/C30H34BrN5O3/c1-35(2)20-23-8-4-5-9-25(23)21-10-12-22(13-11-21)29(38)33-26(30(39)36-16-6-3-7-17-36)18-28(37)34-27-15-14-24(31)19-32-27/h4-5,8-15,19,26H,3,6-7,16-18,20H2,1-2H3,(H,33,38)(H,32,34,37)/t26-/m1/s1
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More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (KDM4C)


(Homo sapiens (Human))
BDBM195612
PNG
(GSK467)
Show SMILES O=c1[nH]c(Oc2cnn(Cc3ccccc3)c2)nc2cnccc12
Show InChI InChI=1S/C17H13N5O2/c23-16-14-6-7-18-9-15(14)20-17(21-16)24-13-8-19-22(11-13)10-12-4-2-1-3-5-12/h1-9,11H,10H2,(H,20,21,23)
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More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (KDM4C)


(Homo sapiens (Human))
BDBM50149918
PNG
(CHEMBL3769853)
Show SMILES CN(C)Cc1nccn1-c1ccc(cc1)C(=O)N[C@@H](CC(=O)Nc1ccc(Cl)cn1)C(=O)N1CCCCC1
Show InChI InChI=1S/C27H32ClN7O3/c1-33(2)18-24-29-12-15-35(24)21-9-6-19(7-10-21)26(37)31-22(27(38)34-13-4-3-5-14-34)16-25(36)32-23-11-8-20(28)17-30-23/h6-12,15,17,22H,3-5,13-14,16,18H2,1-2H3,(H,31,37)(H,30,32,36)/t22-/m0/s1
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More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (KDM4C)


(Homo sapiens (Human))
BDBM50149921
PNG
(CHEMBL3769840)
Show SMILES CS(=O)(=O)NC(CNC(=O)c1ccc(cc1)-c1ccccc1S(N)(=O)=O)C(=O)Nc1ccc(Br)cn1
Show InChI InChI=1S/C22H22BrN5O6S2/c1-35(31,32)28-18(22(30)27-20-11-10-16(23)12-25-20)13-26-21(29)15-8-6-14(7-9-15)17-4-2-3-5-19(17)36(24,33)34/h2-12,18,28H,13H2,1H3,(H,26,29)(H2,24,33,34)(H,25,27,30)
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More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (KDM4C)


(Homo sapiens (Human))
BDBM50149927
PNG
(CHEMBL3770190)
Show SMILES Clc1ccc(NC(=O)C[C@@H](NC(=O)c2ccc(cc2)-c2ccccc2CN2CCCC2)C(=O)N2CCCCC2)nc1
Show InChI InChI=1S/C32H36ClN5O3/c33-26-14-15-29(34-21-26)36-30(39)20-28(32(41)38-18-4-1-5-19-38)35-31(40)24-12-10-23(11-13-24)27-9-3-2-8-25(27)22-37-16-6-7-17-37/h2-3,8-15,21,28H,1,4-7,16-20,22H2,(H,35,40)(H,34,36,39)/t28-/m1/s1
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More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (KDM4C)


(Homo sapiens (Human))
BDBM50149928
PNG
(CHEMBL3770926)
Show SMILES NS(=O)(=O)c1ccccc1-c1ccc(NC(=O)C(CC(=O)Nc2ccc(Br)cn2)NC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C28H24BrN5O5S/c29-20-12-15-25(31-17-20)34-26(35)16-23(33-27(36)19-6-2-1-3-7-19)28(37)32-21-13-10-18(11-14-21)22-8-4-5-9-24(22)40(30,38)39/h1-15,17,23H,16H2,(H,32,37)(H,33,36)(H2,30,38,39)(H,31,34,35)
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More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (KDM4C)


(Homo sapiens (Human))
BDBM195610
PNG
(KDM inhibitor, 3)
Show SMILES CCc1c(C)[nH]c2c(cnn2c1=O)C#N
Show InChI InChI=1S/C10H10N4O/c1-3-8-6(2)13-9-7(4-11)5-12-14(9)10(8)15/h5,13H,3H2,1-2H3
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n/an/a 620n/an/an/an/an/an/a



Genentech Inc



Assay Description
High-throughput MS assays were carried out using truncated KDM4C in 384-well V-bottom polypropylene plates (Greiner, Inc.). His-tagged recombinant KD...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (KDM4C)


(Homo sapiens (Human))
BDBM50149920
PNG
(CHEMBL3769724)
Show SMILES CN(C)Cc1nccn1-c1ccc(cc1)C(=O)N[C@H](CC(=O)Nc1ccc(Br)cn1)C(=O)N1CCCCC1
Show InChI InChI=1S/C27H32BrN7O3/c1-33(2)18-24-29-12-15-35(24)21-9-6-19(7-10-21)26(37)31-22(27(38)34-13-4-3-5-14-34)16-25(36)32-23-11-8-20(28)17-30-23/h6-12,15,17,22H,3-5,13-14,16,18H2,1-2H3,(H,31,37)(H,30,32,36)/t22-/m1/s1
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More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (KDM4C)


(Homo sapiens (Human))
BDBM50149932
PNG
(CHEMBL3771289)
Show SMILES CN1CCN=C1c1ccc(cc1)C(=O)N[C@H](CC(=O)Nc1ccc(Br)cn1)C(=O)N1CCCCC1
Show InChI InChI=1S/C25H29BrN6O3/c1-31-14-11-27-23(31)17-5-7-18(8-6-17)24(34)29-20(25(35)32-12-3-2-4-13-32)15-22(33)30-21-10-9-19(26)16-28-21/h5-10,16,20H,2-4,11-15H2,1H3,(H,29,34)(H,28,30,33)/t20-/m1/s1
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More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (KDM4C)


(Homo sapiens (Human))
BDBM50149915
PNG
(CHEMBL3769669)
Show SMILES NS(=O)(=O)c1ccccc1-c1ccc(NC(=O)C(CC(=O)Nc2ccc(Br)cn2)NC(=O)c2ccncc2)cc1
Show InChI InChI=1S/C27H23BrN6O5S/c28-19-7-10-24(31-16-19)34-25(35)15-22(33-26(36)18-11-13-30-14-12-18)27(37)32-20-8-5-17(6-9-20)21-3-1-2-4-23(21)40(29,38)39/h1-14,16,22H,15H2,(H,32,37)(H,33,36)(H2,29,38,39)(H,31,34,35)
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More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM50122002
PNG
(CHEMBL1383671)
Show SMILES Nc1cnccc1C(O)=O
Show InChI InChI=1S/C6H6N2O2/c7-5-3-8-2-1-4(5)6(9)10/h1-3H,7H2,(H,9,10)
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More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (KDM4C)


(Homo sapiens (Human))
BDBM50149914
PNG
(CHEMBL3770030)
Show SMILES NS(=O)(=O)c1ccccc1-c1ccc(cc1)C(=O)NC(CC(=O)Nc1ccc(Br)cn1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C28H24BrN5O5S/c29-20-14-15-25(31-17-20)34-26(35)16-23(28(37)32-21-6-2-1-3-7-21)33-27(36)19-12-10-18(11-13-19)22-8-4-5-9-24(22)40(30,38)39/h1-15,17,23H,16H2,(H,32,37)(H,33,36)(H2,30,38,39)(H,31,34,35)
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More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (KDM4C)


(Homo sapiens (Human))
BDBM50149917
PNG
(CHEMBL3771198)
Show SMILES COC(=O)C(CC(=O)Nc1ccc(Br)cn1)NC(=O)c1ccc(cc1)-c1ccccc1S(N)(=O)=O
Show InChI InChI=1S/C23H21BrN4O6S/c1-34-23(31)18(12-21(29)28-20-11-10-16(24)13-26-20)27-22(30)15-8-6-14(7-9-15)17-4-2-3-5-19(17)35(25,32)33/h2-11,13,18H,12H2,1H3,(H,27,30)(H2,25,32,33)(H,26,28,29)
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More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (KDM4C)


(Homo sapiens (Human))
BDBM50149934
PNG
(CHEMBL3770812)
Show SMILES NS(=O)(=O)c1ccccc1-c1ccc(cc1)C(=O)NC(CC(=O)Nc1ccc(Br)cn1)C(=O)N1CCOCC1
Show InChI InChI=1S/C26H26BrN5O6S/c27-19-9-10-23(29-16-19)31-24(33)15-21(26(35)32-11-13-38-14-12-32)30-25(34)18-7-5-17(6-8-18)20-3-1-2-4-22(20)39(28,36)37/h1-10,16,21H,11-15H2,(H,30,34)(H2,28,36,37)(H,29,31,33)
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More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (KDM4C)


(Homo sapiens (Human))
BDBM50324535
PNG
(3-{[9-(Dimethylamino)nonanoyl](hydroxy)amino}propa...)
Show SMILES CN(C)CCCCCCCCC(=O)N(O)CCC(O)=O
Show InChI InChI=1S/C14H28N2O4/c1-15(2)11-8-6-4-3-5-7-9-13(17)16(20)12-10-14(18)19/h20H,3-12H2,1-2H3,(H,18,19)
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Nagoya City University

Curated by ChEMBL


Assay Description
Inhibition of recombinant His-tagged JMJD2C expressed in Escherichia coli Rosetta 2 (DE3) pLysS cells by formaldehyde dehydrogenase-coupled assay


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (KDM4C)


(Homo sapiens (Human))
BDBM50149933
PNG
(CHEMBL3770515)
Show SMILES CN(C)Cc1ccccc1-c1ccc(cc1)C(=O)N[C@H](CC(=O)Nc1ccc(Cl)cn1)C(=O)N1CCCCC1
Show InChI InChI=1S/C30H34ClN5O3/c1-35(2)20-23-8-4-5-9-25(23)21-10-12-22(13-11-21)29(38)33-26(30(39)36-16-6-3-7-17-36)18-28(37)34-27-15-14-24(31)19-32-27/h4-5,8-15,19,26H,3,6-7,16-18,20H2,1-2H3,(H,33,38)(H,32,34,37)/t26-/m1/s1
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Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (KDM4C)


(Homo sapiens (Human))
BDBM223317
PNG
(KDOAM-1)
Show SMILES OC(=O)c1ccnc(CN2CCNCC2)c1
Show InChI InChI=1S/C11H15N3O2/c15-11(16)9-1-2-13-10(7-9)8-14-5-3-12-4-6-14/h1-2,7,12H,3-6,8H2,(H,15,16)
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University of Oxford





Cell Chem Biol 24: 371-380 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (KDM4C)


(Homo sapiens (Human))
BDBM50324535
PNG
(3-{[9-(Dimethylamino)nonanoyl](hydroxy)amino}propa...)
Show SMILES CN(C)CCCCCCCCC(=O)N(O)CCC(O)=O
Show InChI InChI=1S/C14H28N2O4/c1-15(2)11-8-6-4-3-5-7-9-13(17)16(20)12-10-14(18)19/h20H,3-12H2,1-2H3,(H,18,19)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Kyoto Prefectural University of Medicine

Curated by ChEMBL


Assay Description
Inhibition of KDM4C


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (KDM4C)


(Homo sapiens (Human))
BDBM50149924
PNG
(CHEMBL3769511)
Show SMILES NS(=O)(=O)c1ccccc1-c1ccc(NC(=O)CCNC(=O)c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C22H20ClN3O4S/c23-17-9-5-16(6-10-17)22(28)25-14-13-21(27)26-18-11-7-15(8-12-18)19-3-1-2-4-20(19)31(24,29)30/h1-12H,13-14H2,(H,25,28)(H,26,27)(H2,24,29,30)
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Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (KDM4C)


(Homo sapiens (Human))
BDBM223317
PNG
(KDOAM-1)
Show SMILES OC(=O)c1ccnc(CN2CCNCC2)c1
Show InChI InChI=1S/C11H15N3O2/c15-11(16)9-1-2-13-10(7-9)8-14-5-3-12-4-6-14/h1-2,7,12H,3-6,8H2,(H,15,16)
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n/an/a 1.30E+3n/an/an/an/an/an/a



University of Oxford





Cell Chem Biol 24: 371-380 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (KDM4C)


(Homo sapiens (Human))
BDBM50324529
PNG
(3-({9-[Benzyl(methyl)]amino}nonanoyl(hydroxy)amino...)
Show SMILES CN(CCCCCCCCC(=O)N(O)CCC(O)=O)Cc1ccccc1
Show InChI InChI=1S/C20H32N2O4/c1-21(17-18-11-7-6-8-12-18)15-10-5-3-2-4-9-13-19(23)22(26)16-14-20(24)25/h6-8,11-12,26H,2-5,9-10,13-17H2,1H3,(H,24,25)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Nagoya City University

Curated by ChEMBL


Assay Description
Inhibition of recombinant His-tagged JMJD2C expressed in Escherichia coli Rosetta 2 (DE3) pLysS cells by formaldehyde dehydrogenase-coupled assay


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (KDM4C)


(Homo sapiens (Human))
BDBM26113
PNG
(2,4 PDCA | cid_10365 | pyridine carboxylate, 6a | ...)
Show SMILES OC(=O)c1ccnc(c1)C(O)=O
Show InChI InChI=1S/C7H5NO4/c9-6(10)4-1-2-8-5(3-4)7(11)12/h1-3H,(H,9,10)(H,11,12)
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n/an/a 1.40E+3n/an/an/an/an/an/a



University of Oxford



Assay Description
The demethylase AlphaScreen assay was performed in 384-well plate format using white proxiplates (PerkinElmer), and transfer of compound (100 nl) was...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (KDM4C)


(Homo sapiens (Human))
BDBM50324534
PNG
(3-{[8-(Dimethylamino)octanoyl](hydroxy)amino}propa...)
Show SMILES CN(C)CCCCCCCC(=O)N(O)CCC(O)=O
Show InChI InChI=1S/C13H26N2O4/c1-14(2)10-7-5-3-4-6-8-12(16)15(19)11-9-13(17)18/h19H,3-11H2,1-2H3,(H,17,18)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Nagoya City University

Curated by ChEMBL


Assay Description
Inhibition of recombinant His-tagged JMJD2C expressed in Escherichia coli Rosetta 2 (DE3) pLysS cells by formaldehyde dehydrogenase-coupled assay


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (KDM4C)


(Homo sapiens (Human))
BDBM50324536
PNG
(3-{[10-(Dimethylamino)decanoyl](hydroxy)amino}prop...)
Show SMILES CN(C)CCCCCCCCCC(=O)N(O)CCC(O)=O
Show InChI InChI=1S/C15H30N2O4/c1-16(2)12-9-7-5-3-4-6-8-10-14(18)17(21)13-11-15(19)20/h21H,3-13H2,1-2H3,(H,19,20)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Nagoya City University

Curated by ChEMBL


Assay Description
Inhibition of recombinant His-tagged JMJD2C expressed in Escherichia coli Rosetta 2 (DE3) pLysS cells by formaldehyde dehydrogenase-coupled assay


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (KDM4C)


(Homo sapiens (Human))
BDBM50324530
PNG
(CHEMBL1215590 | tert-Butyl 3-({Hydroxy[9-(methylam...)
Show SMILES CNCCCCCCCCC(=O)N(O)CCC(O)=O
Show InChI InChI=1S/C13H26N2O4/c1-14-10-7-5-3-2-4-6-8-12(16)15(19)11-9-13(17)18/h14,19H,2-11H2,1H3,(H,17,18)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Nagoya City University

Curated by ChEMBL


Assay Description
Inhibition of recombinant His-tagged JMJD2C expressed in Escherichia coli Rosetta 2 (DE3) pLysS cells by formaldehyde dehydrogenase-coupled assay


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (KDM4C)


(Homo sapiens (Human))
BDBM50149912
PNG
(CHEMBL3770657)
Show SMILES NS(=O)(=O)c1ccccc1-c1ccc(cc1)C(=O)NCCNC(=O)c1ccc(Cl)s1
Show InChI InChI=1S/C20H18ClN3O4S2/c21-18-10-9-16(29-18)20(26)24-12-11-23-19(25)14-7-5-13(6-8-14)15-3-1-2-4-17(15)30(22,27)28/h1-10H,11-12H2,(H,23,25)(H,24,26)(H2,22,27,28)
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Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM50149920
PNG
(CHEMBL3769724)
Show SMILES CN(C)Cc1nccn1-c1ccc(cc1)C(=O)N[C@H](CC(=O)Nc1ccc(Br)cn1)C(=O)N1CCCCC1
Show InChI InChI=1S/C27H32BrN7O3/c1-33(2)18-24-29-12-15-35(24)21-9-6-19(7-10-21)26(37)31-22(27(38)34-13-4-3-5-14-34)16-25(36)32-23-11-8-20(28)17-30-23/h6-12,15,17,22H,3-5,13-14,16,18H2,1-2H3,(H,31,37)(H,30,32,36)/t22-/m1/s1
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Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM50150025
PNG
(CHEMBL3770256)
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Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (KDM4C)


(Homo sapiens (Human))
BDBM50149931
PNG
(CHEMBL3770018)
Show SMILES NS(=O)(=O)c1ccccc1-c1ccc(cc1)C(=O)NCCNS(=O)(=O)c1ccc2cc(Br)ccc2c1
Show InChI InChI=1S/C25H22BrN3O5S2/c26-21-11-9-20-16-22(12-10-19(20)15-21)36(33,34)29-14-13-28-25(30)18-7-5-17(6-8-18)23-3-1-2-4-24(23)35(27,31)32/h1-12,15-16,29H,13-14H2,(H,28,30)(H2,27,31,32)
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Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (KDM4C)


(Homo sapiens (Human))
BDBM50149937
PNG
(CHEMBL3769760)
Show SMILES NS(=O)(=O)c1ccccc1-c1ccc(NC(=O)C(CC(=O)Nc2ccc(Br)cn2)NC(=O)C2CCNCC2)cc1
Show InChI InChI=1S/C27H29BrN6O5S/c28-19-7-10-24(31-16-19)34-25(35)15-22(33-26(36)18-11-13-30-14-12-18)27(37)32-20-8-5-17(6-9-20)21-3-1-2-4-23(21)40(29,38)39/h1-10,16,18,22,30H,11-15H2,(H,32,37)(H,33,36)(H2,29,38,39)(H,31,34,35)
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Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (KDM4C)


(Homo sapiens (Human))
BDBM50149925
PNG
(CHEMBL3770740)
Show SMILES NS(=O)(=O)c1ccccc1-c1ccc(cc1)C(=O)NC(CC(=O)Nc1ccc(Br)cn1)C(=O)N1CCCCCC1
Show InChI InChI=1S/C28H30BrN5O5S/c29-21-13-14-25(31-18-21)33-26(35)17-23(28(37)34-15-5-1-2-6-16-34)32-27(36)20-11-9-19(10-12-20)22-7-3-4-8-24(22)40(30,38)39/h3-4,7-14,18,23H,1-2,5-6,15-17H2,(H,32,36)(H2,30,38,39)(H,31,33,35)
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Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (KDM4C)


(Homo sapiens (Human))
BDBM195608
PNG
(CPI-455)
Show SMILES CC(C)c1c([nH]c2c(cnn2c1=O)C#N)-c1ccccc1
Show InChI InChI=1S/C16H14N4O/c1-10(2)13-14(11-6-4-3-5-7-11)19-15-12(8-17)9-18-20(15)16(13)21/h3-7,9-10,19H,1-2H3
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n/an/a 2.00E+3n/an/an/an/an/an/a



Genentech Inc



Assay Description
High-throughput MS assays were carried out using truncated KDM4C in 384-well V-bottom polypropylene plates (Greiner, Inc.). His-tagged recombinant KD...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM50149920
PNG
(CHEMBL3769724)
Show SMILES CN(C)Cc1nccn1-c1ccc(cc1)C(=O)N[C@H](CC(=O)Nc1ccc(Br)cn1)C(=O)N1CCCCC1
Show InChI InChI=1S/C27H32BrN7O3/c1-33(2)18-24-29-12-15-35(24)21-9-6-19(7-10-21)26(37)31-22(27(38)34-13-4-3-5-14-34)16-25(36)32-23-11-8-20(28)17-30-23/h6-12,15,17,22H,3-5,13-14,16,18H2,1-2H3,(H,31,37)(H,30,32,36)/t22-/m1/s1
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Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (KDM4C)


(Homo sapiens (Human))
BDBM50324527
PNG
(4-[(8-Dimethylaminooctyl)-(hydroxyl)amino]-4-oxobu...)
Show SMILES CN(C)CCCCCCCCN(O)C(=O)CCC(O)=O
Show InChI InChI=1S/C14H28N2O4/c1-15(2)11-7-5-3-4-6-8-12-16(20)13(17)9-10-14(18)19/h20H,3-12H2,1-2H3,(H,18,19)
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Nagoya City University

Curated by ChEMBL


Assay Description
Inhibition of recombinant His-tagged JMJD2C expressed in Escherichia coli Rosetta 2 (DE3) pLysS cells by formaldehyde dehydrogenase-coupled assay


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM50149924
PNG
(CHEMBL3769511)
Show SMILES NS(=O)(=O)c1ccccc1-c1ccc(NC(=O)CCNC(=O)c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C22H20ClN3O4S/c23-17-9-5-16(6-10-17)22(28)25-14-13-21(27)26-18-11-7-15(8-12-18)19-3-1-2-4-20(19)31(24,29)30/h1-12H,13-14H2,(H,25,28)(H,26,27)(H2,24,29,30)
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Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM195612
PNG
(GSK467)
Show SMILES O=c1[nH]c(Oc2cnn(Cc3ccccc3)c2)nc2cnccc12
Show InChI InChI=1S/C17H13N5O2/c23-16-14-6-7-18-9-15(14)20-17(21-16)24-13-8-19-22(11-13)10-12-4-2-1-3-5-12/h1-9,11H,10H2,(H,20,21,23)
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Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM50149917
PNG
(CHEMBL3771198)
Show SMILES COC(=O)C(CC(=O)Nc1ccc(Br)cn1)NC(=O)c1ccc(cc1)-c1ccccc1S(N)(=O)=O
Show InChI InChI=1S/C23H21BrN4O6S/c1-34-23(31)18(12-21(29)28-20-11-10-16(24)13-26-20)27-22(30)15-8-6-14(7-9-15)17-4-2-3-5-19(17)35(25,32)33/h2-11,13,18H,12H2,1H3,(H,27,30)(H2,25,32,33)(H,26,28,29)
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Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (KDM4C)


(Homo sapiens (Human))
BDBM50324535
PNG
(3-{[9-(Dimethylamino)nonanoyl](hydroxy)amino}propa...)
Show SMILES CN(C)CCCCCCCCC(=O)N(O)CCC(O)=O
Show InChI InChI=1S/C14H28N2O4/c1-15(2)11-8-6-4-3-5-7-9-13(17)16(20)12-10-14(18)19/h20H,3-12H2,1-2H3,(H,18,19)
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n/an/a 2.20E+3n/an/an/an/an/an/a



Kyoto Prefectural University of Medicine

Curated by ChEMBL


Assay Description
Inhibition of KDM4C (unknown origin) using H3K9me3 peptide and 2-oxoglutarate as substrate after 1 hr by FDH-coupled assay


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (KDM4C)


(Homo sapiens (Human))
BDBM26113
PNG
(2,4 PDCA | cid_10365 | pyridine carboxylate, 6a | ...)
Show SMILES OC(=O)c1ccnc(c1)C(O)=O
Show InChI InChI=1S/C7H5NO4/c9-6(10)4-1-2-8-5(3-4)7(11)12/h1-3H,(H,9,10)(H,11,12)
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n/an/a 2.40E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of KDM4C


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (KDM4C)


(Homo sapiens (Human))
BDBM191599
PNG
(KDOAM-21 | ethyl 2-(((2-((2-(dimethylamino)ethyl)(...)
Show SMILES CCOC(=O)c1ccnc(CNCC(=O)N(CC)CCN(C)C)c1
Show InChI InChI=1S/C17H28N4O3/c1-5-21(10-9-20(3)4)16(22)13-18-12-15-11-14(7-8-19-15)17(23)24-6-2/h7-8,11,18H,5-6,9-10,12-13H2,1-4H3
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n/an/a 2.40E+3n/an/an/an/an/an/a



University of Oxford





Cell Chem Biol 24: 371-380 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM50149918
PNG
(CHEMBL3769853)
Show SMILES CN(C)Cc1nccn1-c1ccc(cc1)C(=O)N[C@@H](CC(=O)Nc1ccc(Cl)cn1)C(=O)N1CCCCC1
Show InChI InChI=1S/C27H32ClN7O3/c1-33(2)18-24-29-12-15-35(24)21-9-6-19(7-10-21)26(37)31-22(27(38)34-13-4-3-5-14-34)16-25(36)32-23-11-8-20(28)17-30-23/h6-12,15,17,22H,3-5,13-14,16,18H2,1-2H3,(H,31,37)(H,30,32,36)/t22-/m0/s1
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
n/an/a 2.51E+3n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (KDM4C)


(Homo sapiens (Human))
BDBM50149913
PNG
(CHEMBL3770270)
Show SMILES OCc1ccccc1-c1ccc(cc1)C(=O)N[C@@H](CC(=O)Nc1ccc(Br)cn1)C(=O)N1CCCCC1
Show InChI InChI=1S/C28H29BrN4O4/c29-22-12-13-25(30-17-22)32-26(35)16-24(28(37)33-14-4-1-5-15-33)31-27(36)20-10-8-19(9-11-20)23-7-3-2-6-21(23)18-34/h2-3,6-13,17,24,34H,1,4-5,14-16,18H2,(H,31,36)(H,30,32,35)/t24-/m0/s1
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
n/an/a 2.51E+3n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
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