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Compile Data Set for Download or QSAR

Found 35 hits Enz. Inhib. hit(s) with Target = 'Lysosomal alpha-mannosidase'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysosomal alpha-mannosidase


(Homo sapiens)
BDBM50168995
PNG
((-)-swainsonine | (1S,2R,8R,8aR)-Octahydro-indoliz...)
Show SMILES O[C@@H]1CN2CCC[C@@H](O)[C@@H]2[C@@H]1O
Show InChI InChI=1S/C8H15NO3/c10-5-2-1-3-9-4-6(11)8(12)7(5)9/h5-8,10-12H,1-4H2/t5-,6-,7-,8-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



Ecole Polytechnique Fédérale de Lausanne

Curated by ChEMBL


Assay Description
Inhibition of alpha-mannosidase in human HCEC


Citation and Details
More data for this
Ligand-Target Pair
Lysosomal alpha-mannosidase


(Homo sapiens)
BDBM50168995
PNG
((-)-swainsonine | (1S,2R,8R,8aR)-Octahydro-indoliz...)
Show SMILES O[C@@H]1CN2CCC[C@@H](O)[C@@H]2[C@@H]1O
Show InChI InChI=1S/C8H15NO3/c10-5-2-1-3-9-4-6(11)8(12)7(5)9/h5-8,10-12H,1-4H2/t5-,6-,7-,8-/m1/s1
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n/an/a 50n/an/an/an/an/an/a



Ecole Polytechnique Fédérale de Lausanne

Curated by ChEMBL


Assay Description
Inhibition of alpha-mannosidase in human LN18 cells


Citation and Details
More data for this
Ligand-Target Pair
Lysosomal alpha-mannosidase


(Homo sapiens)
BDBM50263049
PNG
((3R,4R,5R)-3,4-dihydroxy-5-(((R)-2-hydroxy-1-pheny...)
Show SMILES CN1[C@H](CN[C@@H](CO)c2ccccc2)[C@@H](O)[C@@H](O)C1=O
Show InChI InChI=1S/C14H20N2O4/c1-16-11(12(18)13(19)14(16)20)7-15-10(8-17)9-5-3-2-4-6-9/h2-6,10-13,15,17-19H,7-8H2,1H3/t10-,11+,12+,13+/m0/s1
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n/an/a 500n/an/an/an/an/an/a



Ecole Polytechnique Fédérale de Lausanne

Curated by ChEMBL


Assay Description
Inhibition of alpha-mannosidase in human HCEC


Citation and Details
More data for this
Ligand-Target Pair
Lysosomal alpha-mannosidase


(Homo sapiens)
BDBM50263049
PNG
((3R,4R,5R)-3,4-dihydroxy-5-(((R)-2-hydroxy-1-pheny...)
Show SMILES CN1[C@H](CN[C@@H](CO)c2ccccc2)[C@@H](O)[C@@H](O)C1=O
Show InChI InChI=1S/C14H20N2O4/c1-16-11(12(18)13(19)14(16)20)7-15-10(8-17)9-5-3-2-4-6-9/h2-6,10-13,15,17-19H,7-8H2,1H3/t10-,11+,12+,13+/m0/s1
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n/an/a 500n/an/an/an/an/an/a



Ecole Polytechnique Fédérale de Lausanne

Curated by ChEMBL


Assay Description
Inhibition of alpha-mannosidase in human LNZ308 cells


Citation and Details
More data for this
Ligand-Target Pair
Lysosomal alpha-mannosidase


(Homo sapiens)
BDBM50263091
PNG
((R)-2-(((2R,3R,4R)-3,4-dihydroxy-1-methyl-5-oxopyr...)
Show SMILES CN1[C@H](CN[C@@H](COC(=O)c2ccc(Br)cc2)c2ccccc2)[C@@H](O)[C@@H](O)C1=O
Show InChI InChI=1S/C21H23BrN2O5/c1-24-17(18(25)19(26)20(24)27)11-23-16(13-5-3-2-4-6-13)12-29-21(28)14-7-9-15(22)10-8-14/h2-10,16-19,23,25-26H,11-12H2,1H3/t16-,17+,18+,19+/m0/s1
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n/an/a 750n/an/an/an/an/an/a



Ecole Polytechnique Fédérale de Lausanne

Curated by ChEMBL


Assay Description
Inhibition of alpha-mannosidase in human HCEC


Citation and Details
More data for this
Ligand-Target Pair
Lysosomal alpha-mannosidase


(Homo sapiens)
BDBM50263049
PNG
((3R,4R,5R)-3,4-dihydroxy-5-(((R)-2-hydroxy-1-pheny...)
Show SMILES CN1[C@H](CN[C@@H](CO)c2ccccc2)[C@@H](O)[C@@H](O)C1=O
Show InChI InChI=1S/C14H20N2O4/c1-16-11(12(18)13(19)14(16)20)7-15-10(8-17)9-5-3-2-4-6-9/h2-6,10-13,15,17-19H,7-8H2,1H3/t10-,11+,12+,13+/m0/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



Ecole Polytechnique Fédérale de Lausanne

Curated by ChEMBL


Assay Description
Inhibition of alpha-mannosidase in human LN18 cells


Citation and Details
More data for this
Ligand-Target Pair
Lysosomal alpha-mannosidase


(Homo sapiens)
BDBM50263091
PNG
((R)-2-(((2R,3R,4R)-3,4-dihydroxy-1-methyl-5-oxopyr...)
Show SMILES CN1[C@H](CN[C@@H](COC(=O)c2ccc(Br)cc2)c2ccccc2)[C@@H](O)[C@@H](O)C1=O
Show InChI InChI=1S/C21H23BrN2O5/c1-24-17(18(25)19(26)20(24)27)11-23-16(13-5-3-2-4-6-13)12-29-21(28)14-7-9-15(22)10-8-14/h2-10,16-19,23,25-26H,11-12H2,1H3/t16-,17+,18+,19+/m0/s1
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n/an/a 7.50E+3n/an/an/an/an/an/a



Ecole Polytechnique Fédérale de Lausanne

Curated by ChEMBL


Assay Description
Inhibition of alpha-mannosidase in human LNZ308 cells


Citation and Details
More data for this
Ligand-Target Pair
Lysosomal alpha-mannosidase


(Homo sapiens)
BDBM50168995
PNG
((-)-swainsonine | (1S,2R,8R,8aR)-Octahydro-indoliz...)
Show SMILES O[C@@H]1CN2CCC[C@@H](O)[C@@H]2[C@@H]1O
Show InChI InChI=1S/C8H15NO3/c10-5-2-1-3-9-4-6(11)8(12)7(5)9/h5-8,10-12H,1-4H2/t5-,6-,7-,8-/m1/s1
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n/an/a 2.00E+4n/an/an/an/an/an/a



Ecole Polytechnique Fédérale de Lausanne

Curated by ChEMBL


Assay Description
Inhibition of alpha-mannosidase in human LNZ308 cells


Citation and Details
More data for this
Ligand-Target Pair
Lysosomal alpha-mannosidase


(Homo sapiens)
BDBM50168988
PNG
((2R,3R,4S)-2-({[(1R)-2-HYDROXY-1-PHENYLETHYL]AMINO...)
Show SMILES OC[C@H](NC[C@H]1NC[C@H](O)[C@@H]1O)c1ccccc1
Show InChI InChI=1S/C13H20N2O3/c16-8-11(9-4-2-1-3-5-9)14-6-10-13(18)12(17)7-15-10/h1-5,10-18H,6-8H2/t10-,11+,12+,13-/m1/s1
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n/an/a 2.50E+4n/an/an/an/an/an/a



Ecole Polytechnique Fédérale de Lausanne

Curated by ChEMBL


Assay Description
Inhibition of alpha-mannosidase in human HCEC


Citation and Details
More data for this
Ligand-Target Pair
Lysosomal alpha-mannosidase


(Homo sapiens)
BDBM50263048
PNG
((3R,4R,5R)-3,4-dihydroxy-5-(((R)-2-hydroxy-1-pheny...)
Show SMILES OC[C@H](NC[C@H]1NC(=O)[C@H](O)[C@@H]1O)c1ccccc1
Show InChI InChI=1S/C13H18N2O4/c16-7-10(8-4-2-1-3-5-8)14-6-9-11(17)12(18)13(19)15-9/h1-5,9-12,14,16-18H,6-7H2,(H,15,19)/t9-,10+,11-,12-/m1/s1
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n/an/a 5.00E+4n/an/an/an/an/an/a



Ecole Polytechnique Fédérale de Lausanne

Curated by ChEMBL


Assay Description
Inhibition of alpha-mannosidase in human LNZ308 cells


Citation and Details
More data for this
Ligand-Target Pair
Lysosomal alpha-mannosidase


(Homo sapiens)
BDBM50168988
PNG
((2R,3R,4S)-2-({[(1R)-2-HYDROXY-1-PHENYLETHYL]AMINO...)
Show SMILES OC[C@H](NC[C@H]1NC[C@H](O)[C@@H]1O)c1ccccc1
Show InChI InChI=1S/C13H20N2O3/c16-8-11(9-4-2-1-3-5-9)14-6-10-13(18)12(17)7-15-10/h1-5,10-18H,6-8H2/t10-,11+,12+,13-/m1/s1
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n/an/a 5.00E+4n/an/an/an/an/an/a



Ecole Polytechnique Fédérale de Lausanne

Curated by ChEMBL


Assay Description
Inhibition of alpha-mannosidase in human LNZ308 cells


Citation and Details
More data for this
Ligand-Target Pair
Lysosomal alpha-mannosidase


(Homo sapiens)
BDBM50168988
PNG
((2R,3R,4S)-2-({[(1R)-2-HYDROXY-1-PHENYLETHYL]AMINO...)
Show SMILES OC[C@H](NC[C@H]1NC[C@H](O)[C@@H]1O)c1ccccc1
Show InChI InChI=1S/C13H20N2O3/c16-8-11(9-4-2-1-3-5-9)14-6-10-13(18)12(17)7-15-10/h1-5,10-18H,6-8H2/t10-,11+,12+,13-/m1/s1
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n/an/a 5.00E+4n/an/an/an/an/an/a



Ecole Polytechnique Fédérale de Lausanne

Curated by ChEMBL


Assay Description
Inhibition of alpha-mannosidase in human LN18 cells


Citation and Details
More data for this
Ligand-Target Pair
Lysosomal alpha-mannosidase


(Homo sapiens)
BDBM50163438
PNG
((2S,3S,4R,5R)-2-Hydroxymethyl-piperidine-3,4,5-tri...)
Show SMILES OC[C@@H]1NC[C@@H](O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6+/m0/s1
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n/an/a 6.40E+4n/an/an/an/an/an/a



Toyama Medical and Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibitory concentration against human alpha-mannosidase


Citation and Details
More data for this
Ligand-Target Pair
Lysosomal alpha-mannosidase


(Homo sapiens)
BDBM50263050
PNG
((R)-2-(((2R,3R,4R)-3,4-dihydroxy-5-oxopyrrolidin-2...)
Show SMILES O[C@@H]1[C@@H](CN[C@@H](COC(=O)c2ccc(Br)cc2)c2ccccc2)NC(=O)[C@@H]1O
Show InChI InChI=1S/C20H21BrN2O5/c21-14-8-6-13(7-9-14)20(27)28-11-16(12-4-2-1-3-5-12)22-10-15-17(24)18(25)19(26)23-15/h1-9,15-18,22,24-25H,10-11H2,(H,23,26)/t15-,16+,17-,18-/m1/s1
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n/an/a 7.50E+4n/an/an/an/an/an/a



Ecole Polytechnique Fédérale de Lausanne

Curated by ChEMBL


Assay Description
Inhibition of alpha-mannosidase in human HCEC


Citation and Details
More data for this
Ligand-Target Pair
Lysosomal alpha-mannosidase


(Homo sapiens)
BDBM50263047
PNG
((R)-2-(((2R,3R,4S)-3,4-dihydroxypyrrolidin-2-yl)me...)
Show SMILES O[C@H]1CN[C@H](CN[C@@H](COC(=O)c2ccc(Br)cc2)c2ccccc2)[C@H]1O
Show InChI InChI=1S/C20H23BrN2O4/c21-15-8-6-14(7-9-15)20(26)27-12-17(13-4-2-1-3-5-13)22-10-16-19(25)18(24)11-23-16/h1-9,16-19,22-25H,10-12H2/t16-,17+,18+,19-/m1/s1
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n/an/a 7.50E+4n/an/an/an/an/an/a



Ecole Polytechnique Fédérale de Lausanne

Curated by ChEMBL


Assay Description
Inhibition of alpha-mannosidase in human LNZ308 cells


Citation and Details
More data for this
Ligand-Target Pair
Lysosomal alpha-mannosidase


(Homo sapiens)
BDBM50263047
PNG
((R)-2-(((2R,3R,4S)-3,4-dihydroxypyrrolidin-2-yl)me...)
Show SMILES O[C@H]1CN[C@H](CN[C@@H](COC(=O)c2ccc(Br)cc2)c2ccccc2)[C@H]1O
Show InChI InChI=1S/C20H23BrN2O4/c21-15-8-6-14(7-9-15)20(26)27-12-17(13-4-2-1-3-5-13)22-10-16-19(25)18(24)11-23-16/h1-9,16-19,22-25H,10-12H2/t16-,17+,18+,19-/m1/s1
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n/an/a 7.50E+4n/an/an/an/an/an/a



Ecole Polytechnique Fédérale de Lausanne

Curated by ChEMBL


Assay Description
Inhibition of alpha-mannosidase in human HCEC


Citation and Details
More data for this
Ligand-Target Pair
Lysosomal alpha-mannosidase


(Homo sapiens)
BDBM50263048
PNG
((3R,4R,5R)-3,4-dihydroxy-5-(((R)-2-hydroxy-1-pheny...)
Show SMILES OC[C@H](NC[C@H]1NC(=O)[C@H](O)[C@@H]1O)c1ccccc1
Show InChI InChI=1S/C13H18N2O4/c16-7-10(8-4-2-1-3-5-8)14-6-9-11(17)12(18)13(19)15-9/h1-5,9-12,14,16-18H,6-7H2,(H,15,19)/t9-,10+,11-,12-/m1/s1
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n/an/a 7.50E+4n/an/an/an/an/an/a



Ecole Polytechnique Fédérale de Lausanne

Curated by ChEMBL


Assay Description
Inhibition of alpha-mannosidase in human HCEC


Citation and Details
More data for this
Ligand-Target Pair
Lysosomal alpha-mannosidase


(Homo sapiens)
BDBM50263091
PNG
((R)-2-(((2R,3R,4R)-3,4-dihydroxy-1-methyl-5-oxopyr...)
Show SMILES CN1[C@H](CN[C@@H](COC(=O)c2ccc(Br)cc2)c2ccccc2)[C@@H](O)[C@@H](O)C1=O
Show InChI InChI=1S/C21H23BrN2O5/c1-24-17(18(25)19(26)20(24)27)11-23-16(13-5-3-2-4-6-13)12-29-21(28)14-7-9-15(22)10-8-14/h2-10,16-19,23,25-26H,11-12H2,1H3/t16-,17+,18+,19+/m0/s1
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n/an/a 7.50E+4n/an/an/an/an/an/a



Ecole Polytechnique Fédérale de Lausanne

Curated by ChEMBL


Assay Description
Inhibition of alpha-mannosidase in human LN18 cells


Citation and Details
More data for this
Ligand-Target Pair
Lysosomal alpha-mannosidase


(Homo sapiens)
BDBM50030374
PNG
(CHEMBL3344206)
Show SMILES CCCCCCCCCCN1C[C@H](O)C(O)(CCO)[C@H](O)C1
Show InChI InChI=1/C17H35NO4/c1-2-3-4-5-6-7-8-9-11-18-13-15(20)17(22,10-12-19)16(21)14-18/h15-16,19-22H,2-14H2,1H3/t15-,16+,17?
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n/an/a 1.12E+5n/an/an/an/an/an/a



University of Pune

Curated by ChEMBL


Assay Description
Inhibition of alpha-mannosidase (unknown origin) using p-nitrophenyl-alpha-D-mannopyranoside substrate incubated for 10 mins by UV spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Lysosomal alpha-mannosidase


(Homo sapiens)
BDBM50030343
PNG
(CHEMBL3344205)
Show SMILES CCCCCCCCN1C[C@H](O)C(O)(CCO)[C@H](O)C1
Show InChI InChI=1/C15H31NO4/c1-2-3-4-5-6-7-9-16-11-13(18)15(20,8-10-17)14(19)12-16/h13-14,17-20H,2-12H2,1H3/t13-,14+,15?
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n/an/a 1.43E+5n/an/an/an/an/an/a



University of Pune

Curated by ChEMBL


Assay Description
Inhibition of alpha-mannosidase (unknown origin) using p-nitrophenyl-alpha-D-mannopyranoside substrate incubated for 10 mins by UV spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Lysosomal alpha-mannosidase


(Homo sapiens)
BDBM50263050
PNG
((R)-2-(((2R,3R,4R)-3,4-dihydroxy-5-oxopyrrolidin-2...)
Show SMILES O[C@@H]1[C@@H](CN[C@@H](COC(=O)c2ccc(Br)cc2)c2ccccc2)NC(=O)[C@@H]1O
Show InChI InChI=1S/C20H21BrN2O5/c21-14-8-6-13(7-9-14)20(27)28-11-16(12-4-2-1-3-5-12)22-10-15-17(24)18(25)19(26)23-15/h1-9,15-18,22,24-25H,10-11H2,(H,23,26)/t15-,16+,17-,18-/m1/s1
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n/an/a 1.50E+5n/an/an/an/an/an/a



Ecole Polytechnique Fédérale de Lausanne

Curated by ChEMBL


Assay Description
Inhibition of alpha-mannosidase in human LNZ308 cells


Citation and Details
More data for this
Ligand-Target Pair
Lysosomal alpha-mannosidase


(Homo sapiens)
BDBM50030342
PNG
(CHEMBL3344204)
Show SMILES CCCCCCN1C[C@H](O)C(O)(CCO)[C@H](O)C1
Show InChI InChI=1/C13H27NO4/c1-2-3-4-5-7-14-9-11(16)13(18,6-8-15)12(17)10-14/h11-12,15-18H,2-10H2,1H3/t11-,12+,13?
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n/an/a 1.83E+5n/an/an/an/an/an/a



University of Pune

Curated by ChEMBL


Assay Description
Inhibition of alpha-mannosidase (unknown origin) using p-nitrophenyl-alpha-D-mannopyranoside substrate incubated for 10 mins by UV spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Lysosomal alpha-mannosidase


(Homo sapiens)
BDBM50263047
PNG
((R)-2-(((2R,3R,4S)-3,4-dihydroxypyrrolidin-2-yl)me...)
Show SMILES O[C@H]1CN[C@H](CN[C@@H](COC(=O)c2ccc(Br)cc2)c2ccccc2)[C@H]1O
Show InChI InChI=1S/C20H23BrN2O4/c21-15-8-6-14(7-9-15)20(26)27-12-17(13-4-2-1-3-5-13)22-10-16-19(25)18(24)11-23-16/h1-9,16-19,22-25H,10-12H2/t16-,17+,18+,19-/m1/s1
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n/an/a 2.00E+5n/an/an/an/an/an/a



Ecole Polytechnique Fédérale de Lausanne

Curated by ChEMBL


Assay Description
Inhibition of alpha-mannosidase in human LN18 cells


Citation and Details
More data for this
Ligand-Target Pair
Lysosomal alpha-mannosidase


(Homo sapiens)
BDBM50030340
PNG
(CHEMBL3344203)
Show SMILES CCCCN1C[C@H](O)C(O)(CCO)[C@H](O)C1
Show InChI InChI=1/C11H23NO4/c1-2-3-5-12-7-9(14)11(16,4-6-13)10(15)8-12/h9-10,13-16H,2-8H2,1H3/t9-,10+,11?
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n/an/a 2.52E+5n/an/an/an/an/an/a



University of Pune

Curated by ChEMBL


Assay Description
Inhibition of alpha-mannosidase (unknown origin) using p-nitrophenyl-alpha-D-mannopyranoside substrate incubated for 10 mins by UV spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Lysosomal alpha-mannosidase


(Homo sapiens)
BDBM50263048
PNG
((3R,4R,5R)-3,4-dihydroxy-5-(((R)-2-hydroxy-1-pheny...)
Show SMILES OC[C@H](NC[C@H]1NC(=O)[C@H](O)[C@@H]1O)c1ccccc1
Show InChI InChI=1S/C13H18N2O4/c16-7-10(8-4-2-1-3-5-8)14-6-9-11(17)12(18)13(19)15-9/h1-5,9-12,14,16-18H,6-7H2,(H,15,19)/t9-,10+,11-,12-/m1/s1
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n/an/a 3.50E+5n/an/an/an/an/an/a



Ecole Polytechnique Fédérale de Lausanne

Curated by ChEMBL


Assay Description
Inhibition of alpha-mannosidase in human LN18 cells


Citation and Details
More data for this
Ligand-Target Pair
Lysosomal alpha-mannosidase


(Homo sapiens)
BDBM50242271
PNG
((2R,3R,4R,5S)-1-(2-hydroxyethyl)-2-(hydroxymethyl)...)
Show SMILES OCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C8H17NO5/c10-2-1-9-3-6(12)8(14)7(13)5(9)4-11/h5-8,10-14H,1-4H2/t5-,6+,7-,8-/m1/s1
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n/an/a 3.79E+5n/an/an/an/an/an/a



University of Pune

Curated by ChEMBL


Assay Description
Inhibition of alpha-mannosidase (unknown origin) using p-nitrophenyl-alpha-D-mannopyranoside substrate incubated for 10 mins by UV spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Lysosomal alpha-mannosidase


(Homo sapiens)
BDBM50263050
PNG
((R)-2-(((2R,3R,4R)-3,4-dihydroxy-5-oxopyrrolidin-2...)
Show SMILES O[C@@H]1[C@@H](CN[C@@H](COC(=O)c2ccc(Br)cc2)c2ccccc2)NC(=O)[C@@H]1O
Show InChI InChI=1S/C20H21BrN2O5/c21-14-8-6-13(7-9-14)20(27)28-11-16(12-4-2-1-3-5-12)22-10-15-17(24)18(25)19(26)23-15/h1-9,15-18,22,24-25H,10-11H2,(H,23,26)/t15-,16+,17-,18-/m1/s1
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n/an/a 7.50E+5n/an/an/an/an/an/a



Ecole Polytechnique Fédérale de Lausanne

Curated by ChEMBL


Assay Description
Inhibition of alpha-mannosidase in human LN18 cells


Citation and Details
More data for this
Ligand-Target Pair
Lysosomal alpha-mannosidase


(Homo sapiens)
BDBM50030341
PNG
(CHEMBL3344207)
Show SMILES OCCN1C[C@H](O)C(O)(CCO)[C@H](O)C1
Show InChI InChI=1/C9H19NO5/c11-3-1-9(15)7(13)5-10(2-4-12)6-8(9)14/h7-8,11-15H,1-6H2/t7-,8+,9?
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n/an/a 8.73E+5n/an/an/an/an/an/a



University of Pune

Curated by ChEMBL


Assay Description
Inhibition of alpha-mannosidase (unknown origin) using p-nitrophenyl-alpha-D-mannopyranoside substrate incubated for 10 mins by UV spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Lysosomal alpha-mannosidase


(Homo sapiens)
BDBM50030339
PNG
(CHEMBL3344202)
Show SMILES OCCC1(O)[C@@H](O)CNC[C@H]1O
Show InChI InChI=1/C7H15NO4/c9-2-1-7(12)5(10)3-8-4-6(7)11/h5-6,8-12H,1-4H2/t5-,6+,7?
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n/an/a 1.83E+6n/an/an/an/an/an/a



University of Pune

Curated by ChEMBL


Assay Description
Inhibition of alpha-mannosidase (unknown origin) using p-nitrophenyl-alpha-D-mannopyranoside substrate incubated for 10 mins by UV spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Lysosomal alpha-mannosidase


(Homo sapiens)
BDBM50263049
PNG
((3R,4R,5R)-3,4-dihydroxy-5-(((R)-2-hydroxy-1-pheny...)
Show SMILES CN1[C@H](CN[C@@H](CO)c2ccccc2)[C@@H](O)[C@@H](O)C1=O
Show InChI InChI=1S/C14H20N2O4/c1-16-11(12(18)13(19)14(16)20)7-15-10(8-17)9-5-3-2-4-6-9/h2-6,10-13,15,17-19H,7-8H2,1H3/t10-,11+,12+,13+/m0/s1
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550n/an/an/an/an/an/an/an/a



Ecole Polytechnique Fédérale de Lausanne

Curated by ChEMBL


Assay Description
Inhibition of alpha-mannosidase in human LNZ308 cells


Citation and Details
More data for this
Ligand-Target Pair
Lysosomal alpha-mannosidase


(Homo sapiens)
BDBM50263049
PNG
((3R,4R,5R)-3,4-dihydroxy-5-(((R)-2-hydroxy-1-pheny...)
Show SMILES CN1[C@H](CN[C@@H](CO)c2ccccc2)[C@@H](O)[C@@H](O)C1=O
Show InChI InChI=1S/C14H20N2O4/c1-16-11(12(18)13(19)14(16)20)7-15-10(8-17)9-5-3-2-4-6-9/h2-6,10-13,15,17-19H,7-8H2,1H3/t10-,11+,12+,13+/m0/s1
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670n/an/an/an/an/an/an/an/a



Ecole Polytechnique Fédérale de Lausanne

Curated by ChEMBL


Assay Description
Inhibition of alpha-mannosidase in human HCEC


Citation and Details
More data for this
Ligand-Target Pair
Lysosomal alpha-mannosidase


(Homo sapiens)
BDBM50263049
PNG
((3R,4R,5R)-3,4-dihydroxy-5-(((R)-2-hydroxy-1-pheny...)
Show SMILES CN1[C@H](CN[C@@H](CO)c2ccccc2)[C@@H](O)[C@@H](O)C1=O
Show InChI InChI=1S/C14H20N2O4/c1-16-11(12(18)13(19)14(16)20)7-15-10(8-17)9-5-3-2-4-6-9/h2-6,10-13,15,17-19H,7-8H2,1H3/t10-,11+,12+,13+/m0/s1
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3.20E+3n/an/an/an/an/an/an/an/a



Ecole Polytechnique Fédérale de Lausanne

Curated by ChEMBL


Assay Description
Inhibition of alpha-mannosidase in human LN18 cells


Citation and Details
More data for this
Ligand-Target Pair
Lysosomal alpha-mannosidase


(Homo sapiens)
BDBM50168988
PNG
((2R,3R,4S)-2-({[(1R)-2-HYDROXY-1-PHENYLETHYL]AMINO...)
Show SMILES OC[C@H](NC[C@H]1NC[C@H](O)[C@@H]1O)c1ccccc1
Show InChI InChI=1S/C13H20N2O3/c16-8-11(9-4-2-1-3-5-9)14-6-10-13(18)12(17)7-15-10/h1-5,10-18H,6-8H2/t10-,11+,12+,13-/m1/s1
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2.33E+4n/an/an/an/an/an/an/an/a



Ecole Polytechnique Fédérale de Lausanne

Curated by ChEMBL


Assay Description
Inhibition of alpha-mannosidase in human HCEC


Citation and Details
More data for this
Ligand-Target Pair
Lysosomal alpha-mannosidase


(Homo sapiens)
BDBM50168988
PNG
((2R,3R,4S)-2-({[(1R)-2-HYDROXY-1-PHENYLETHYL]AMINO...)
Show SMILES OC[C@H](NC[C@H]1NC[C@H](O)[C@@H]1O)c1ccccc1
Show InChI InChI=1S/C13H20N2O3/c16-8-11(9-4-2-1-3-5-9)14-6-10-13(18)12(17)7-15-10/h1-5,10-18H,6-8H2/t10-,11+,12+,13-/m1/s1
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3.25E+4n/an/an/an/an/an/an/an/a



Ecole Polytechnique Fédérale de Lausanne

Curated by ChEMBL


Assay Description
Inhibition of alpha-mannosidase in human LN18 cells


Citation and Details
More data for this
Ligand-Target Pair
Lysosomal alpha-mannosidase


(Homo sapiens)
BDBM50168988
PNG
((2R,3R,4S)-2-({[(1R)-2-HYDROXY-1-PHENYLETHYL]AMINO...)
Show SMILES OC[C@H](NC[C@H]1NC[C@H](O)[C@@H]1O)c1ccccc1
Show InChI InChI=1S/C13H20N2O3/c16-8-11(9-4-2-1-3-5-9)14-6-10-13(18)12(17)7-15-10/h1-5,10-18H,6-8H2/t10-,11+,12+,13-/m1/s1
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4.15E+4n/an/an/an/an/an/an/an/a



Ecole Polytechnique Fédérale de Lausanne

Curated by ChEMBL


Assay Description
Inhibition of alpha-mannosidase in human LNZ308 cells


Citation and Details
More data for this
Ligand-Target Pair