Compile Data Set for Download or QSAR

Found 49 hits Enz. Inhib. hit(s) with Target = 'MAP Kinase p38 beta'   

Target (Institution)	Ligand	Target Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MAP Kinase p38 beta (Mus musculus (mouse))	BDBM16530 (2-arylpyridazin-3-one, 36 | N-{3-[(2-chlorophenyl)...) Show SMILES FC(F)(F)C1CCC(CC1)C(=O)NCCCN(c1ccc(=O)n(n1)-c1ccccc1Cl)c1ccccc1Cl Show InChI InChI=1S/C27H27Cl2F3N4O2/c28-20-6-1-3-8-22(20)35(24-14-15-25(37)36(34-24)23-9-4-2-7-21(23)29)17-5-16-33-26(38)18-10-12-19(13-11-18)27(30,31)32/h1-4,6-9,14-15,18-19H,5,10-13,16-17H2,(H,33,38)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...				Bioorg Med Chem Lett 16: 5809-13 (2006)
					More data for this Ligand-Target Pair
MAP kinase p38 beta (Mus musculus (mouse))	BDBM50421141 (CHEMBL2088578) Show SMILES COC(=O)c1ccc(C=C)c(c1)-c1c2ccc(Oc3ccc(F)cc3F)nn2ccc1=O Show InChI InChI=1S/C24H16F2N2O4/c1-3-14-4-5-15(24(30)31-2)12-17(14)23-19-7-9-22(27-28(19)11-10-20(23)29)32-21-8-6-16(25)13-18(21)26/h3-13H,1H2,2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars AffyNet	Article PubMed	n/a	n/a	7.70	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of mouse p38beta assessed as reduction in GST-ATF2 substrate phosphorylation by SPA assay				Bioorg Med Chem Lett 22: 5979-83 (2012)
					More data for this Ligand-Target Pair
MAP kinase p38 beta (Mus musculus (mouse))	BDBM50421140 (CHEMBL2088591) Show SMILES COc1ccc(cc1-c1c2ccc(Oc3ccc(F)cc3F)nn2ccc1=O)-c1nnc(C)o1 Show InChI InChI=1S/C24H16F2N4O4/c1-13-27-28-24(33-13)14-3-6-20(32-2)16(11-14)23-18-5-8-22(29-30(18)10-9-19(23)31)34-21-7-4-15(25)12-17(21)26/h3-12H,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars AffyNet	Article PubMed	n/a	n/a	8.5	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of mouse p38beta assessed as reduction in GST-ATF2 substrate phosphorylation by SPA assay				Bioorg Med Chem Lett 22: 5979-83 (2012)
					More data for this Ligand-Target Pair
MAP kinase p38 beta (Mus musculus (mouse))	BDBM50317579 (6-(2,4-difluorophenyl)-1-(2,6-difluorophenyl)-2H-q...) Show SMILES Fc1ccc(c(F)c1)-c1cccc2c(-c3c(F)cccc3F)c(=O)ccn12 Show InChI InChI=1S/C21H11F4NO/c22-12-7-8-13(16(25)11-12)17-5-2-6-18-21(19(27)9-10-26(17)18)20-14(23)3-1-4-15(20)24/h1-11H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars AffyNet	Article PubMed	n/a	n/a	9.20	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of mouse p38beta assessed as reduction in GST-ATF2 substrate phosphorylation by SPA assay				Bioorg Med Chem Lett 22: 5979-83 (2012)
					More data for this Ligand-Target Pair
MAP kinase p38 beta (Mus musculus (mouse))	BDBM50421137 (CHEMBL2088588) Show SMILES COC(=O)c1ccc(OC)c(c1)-c1c2ccc(Oc3ccc(F)cc3F)nn2ccc1=O Show InChI InChI=1S/C23H16F2N2O5/c1-30-19-6-3-13(23(29)31-2)11-15(19)22-17-5-8-21(26-27(17)10-9-18(22)28)32-20-7-4-14(24)12-16(20)25/h3-12H,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars AffyNet	Article PubMed	n/a	n/a	9.30	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of mouse p38beta assessed as reduction in GST-ATF2 substrate phosphorylation by SPA assay				Bioorg Med Chem Lett 22: 5979-83 (2012)
					More data for this Ligand-Target Pair
MAP Kinase p38 beta (Mus musculus (mouse))	BDBM16524 (2-arylpyridazin-3-one, 30 | 2-{3-[(2-chlorophenyl)...) Show SMILES Clc1ccccc1N(CCCN1C(=O)c2ccccc2C1=O)c1ccc(=O)n(n1)-c1ccccc1Cl Show InChI InChI=1S/C27H20Cl2N4O3/c28-20-10-3-5-12-22(20)31(16-7-17-32-26(35)18-8-1-2-9-19(18)27(32)36)24-14-15-25(34)33(30-24)23-13-6-4-11-21(23)29/h1-6,8-15H,7,16-17H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...				Bioorg Med Chem Lett 16: 5809-13 (2006)
					More data for this Ligand-Target Pair
MAP kinase p38 beta (Mus musculus (mouse))	BDBM50317588 (6-(2,4-difluorophenyl)-1-(2-fluoro-5-(5-methyl-1,3...) Show SMILES Cc1nnc(o1)-c1ccc(F)c(c1)-c1c2cccc(-c3ccc(F)cc3F)n2ccc1=O Show InChI InChI=1S/C24H14F3N3O2/c1-13-28-29-24(32-13)14-5-8-18(26)17(11-14)23-21-4-2-3-20(30(21)10-9-22(23)31)16-7-6-15(25)12-19(16)27/h2-12H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars AffyNet	Article PubMed	n/a	n/a	15.8	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of mouse p38beta assessed as reduction in GST-ATF2 substrate phosphorylation by SPA assay				Bioorg Med Chem Lett 22: 5979-83 (2012)
					More data for this Ligand-Target Pair
MAP kinase p38 beta (Mus musculus (mouse))	BDBM50317583 (1-(2,6-difluoro-4-(5-methyl-1,3,4-oxadiazol-2-yl)p...) Show SMILES Cc1nnc(o1)-c1cc(F)c(c(F)c1)-c1c2cccc(-c3ccc(F)cc3F)n2ccc1=O Show InChI InChI=1S/C24H13F4N3O2/c1-12-29-30-24(33-12)13-9-17(27)22(18(28)10-13)23-20-4-2-3-19(31(20)8-7-21(23)32)15-6-5-14(25)11-16(15)26/h2-11H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars AffyNet	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of mouse p38beta assessed as reduction in GST-ATF2 substrate phosphorylation by SPA assay				Bioorg Med Chem Lett 22: 5979-83 (2012)
					More data for this Ligand-Target Pair
MAP Kinase p38 beta (Mus musculus (mouse))	BDBM16525 (2-arylpyridazin-3-one, 31 | 2-{3-[(2-chloro-4-fluo...) Show SMILES Fc1ccc(N(CCCN2C(=O)c3ccccc3C2=O)c2ccc(=O)n(n2)-c2ccccc2Cl)c(Cl)c1 Show InChI InChI=1S/C27H19Cl2FN4O3/c28-20-8-3-4-9-23(20)34-25(35)13-12-24(31-34)32(22-11-10-17(30)16-21(22)29)14-5-15-33-26(36)18-6-1-2-7-19(18)27(33)37/h1-4,6-13,16H,5,14-15H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Similars AffyNet	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...				Bioorg Med Chem Lett 16: 5809-13 (2006)
					More data for this Ligand-Target Pair
MAP kinase p38 beta (Mus musculus (mouse))	BDBM50421127 (CHEMBL2088582) Show SMILES COC(=O)c1ccc(F)c(c1)-c1c2ccc(Oc3ccc(F)cc3F)nn2ccc1=O Show InChI InChI=1S/C22H13F3N2O4/c1-30-22(29)12-2-4-15(24)14(10-12)21-17-5-7-20(26-27(17)9-8-18(21)28)31-19-6-3-13(23)11-16(19)25/h2-11H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars AffyNet	Article PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of mouse p38beta assessed as reduction in GST-ATF2 substrate phosphorylation by SPA assay				Bioorg Med Chem Lett 22: 5979-83 (2012)
					More data for this Ligand-Target Pair
MAP kinase p38 beta (Mus musculus (mouse))	BDBM50122916 (6-[2-(2-Chloro-4-fluoro-phenyl)-imidazo[1,2-a]pyri...) Show SMILES Cc1ccccc1-n1nc(ccc1=O)-c1c(nc2ccccn12)-c1ccc(F)cc1Cl Show InChI InChI=1S/C24H16ClFN4O/c1-15-6-2-3-7-20(15)30-22(31)12-11-19(28-30)24-23(17-10-9-16(26)14-18(17)25)27-21-8-4-5-13-29(21)24/h2-14H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars AffyNet	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of [gamma-33P]-ATP binding from active recombinant murine FLAG-Mitogen-activated protein kinase p38 beta fusion protein (GST-ATF2)				J Med Chem 46: 349-52 (2003)
					More data for this Ligand-Target Pair
MAP Kinase p38 beta (Mus musculus (mouse))	BDBM16527 (2-arylpyridazin-3-one, 33 | N-{3-[(2-chlorophenyl)...) Show SMILES CNCC(=O)NCCCN(c1ccc(=O)n(n1)-c1ccccc1Cl)c1ccccc1Cl Show InChI InChI=1S/C22H23Cl2N5O2/c1-25-15-21(30)26-13-6-14-28(18-9-4-2-7-16(18)23)20-11-12-22(31)29(27-20)19-10-5-3-8-17(19)24/h2-5,7-12,25H,6,13-15H2,1H3,(H,26,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...				Bioorg Med Chem Lett 16: 5809-13 (2006)
					More data for this Ligand-Target Pair
MAP Kinase p38 beta (Mus musculus (mouse))	BDBM16529 (2-arylpyridazin-3-one, 35 | N-{3-[(2-chlorophenyl)...) Show SMILES Clc1ccccc1N(CCCNC(=O)C1CCNCC1)c1ccc(=O)n(n1)-c1ccccc1Cl Show InChI InChI=1S/C25H27Cl2N5O2/c26-19-6-1-3-8-21(19)31(17-5-14-29-25(34)18-12-15-28-16-13-18)23-10-11-24(33)32(30-23)22-9-4-2-7-20(22)27/h1-4,6-11,18,28H,5,12-17H2,(H,29,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...				Bioorg Med Chem Lett 16: 5809-13 (2006)
					More data for this Ligand-Target Pair
MAP Kinase p38 beta (Mus musculus (mouse))	BDBM16528 (2-arylpyridazin-3-one, 34 | N-{3-[(2-chlorophenyl)...) Show SMILES Clc1ccccc1N(CCCNC(=O)C1CCCN1)c1ccc(=O)n(n1)-c1ccccc1Cl Show InChI InChI=1S/C24H25Cl2N5O2/c25-17-7-1-3-10-20(17)30(16-6-15-28-24(33)19-9-5-14-27-19)22-12-13-23(32)31(29-22)21-11-4-2-8-18(21)26/h1-4,7-8,10-13,19,27H,5-6,9,14-16H2,(H,28,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	Article PubMed	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...				Bioorg Med Chem Lett 16: 5809-13 (2006)
					More data for this Ligand-Target Pair
MAP kinase p38 beta (Mus musculus (mouse))	BDBM50421133 (CHEMBL2088575) Show SMILES Fc1ccc(Oc2ccc3c(-c4cc(ccc4C=C)C(=O)NC4CC4)c(=O)ccn3n2)c(F)c1 Show InChI InChI=1S/C26H19F2N3O3/c1-2-15-3-4-16(26(33)29-18-6-7-18)13-19(15)25-21-8-10-24(30-31(21)12-11-22(25)32)34-23-9-5-17(27)14-20(23)28/h2-5,8-14,18H,1,6-7H2,(H,29,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars AffyNet	Article PubMed	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of mouse p38beta assessed as reduction in GST-ATF2 substrate phosphorylation by SPA assay				Bioorg Med Chem Lett 22: 5979-83 (2012)
					More data for this Ligand-Target Pair
MAP Kinase p38 beta (Mus musculus (mouse))	BDBM16526 (2-amino-N-{3-[(2-chlorophenyl)[1-(2-chlorophenyl)-...) Show SMILES NCC(=O)NCCCN(c1ccc(=O)n(n1)-c1ccccc1Cl)c1ccccc1Cl Show InChI InChI=1S/C21H21Cl2N5O2/c22-15-6-1-3-8-17(15)27(13-5-12-25-20(29)14-24)19-10-11-21(30)28(26-19)18-9-4-2-7-16(18)23/h1-4,6-11H,5,12-14,24H2,(H,25,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	Article PubMed	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...				Bioorg Med Chem Lett 16: 5809-13 (2006)
					More data for this Ligand-Target Pair
MAP kinase p38 beta (Mus musculus (mouse))	BDBM50122920 (6-[2-(2,3-Dichloro-phenyl)-imidazo[1,2-a]pyridin-3...) Show SMILES Cc1ccccc1-n1nc(ccc1=O)-c1c(nc2ccccn12)-c1cccc(Cl)c1Cl Show InChI InChI=1S/C24H16Cl2N4O/c1-15-7-2-3-10-19(15)30-21(31)13-12-18(28-30)24-23(16-8-6-9-17(25)22(16)26)27-20-11-4-5-14-29(20)24/h2-14H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars AffyNet	Article PubMed	n/a	n/a	44	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of [gamma-33P]-ATP binding from active recombinant murine FLAG-Mitogen-activated protein kinase p38 beta fusion protein (GST-ATF2)				J Med Chem 46: 349-52 (2003)
					More data for this Ligand-Target Pair
MAP kinase p38 beta (Mus musculus (mouse))	BDBM50421132 (CHEMBL2088579) Show SMILES CCCNC(=O)c1ccc(C=C)c(c1)-c1c2ccc(Oc3ccc(F)cc3F)nn2ccc1=O Show InChI InChI=1S/C26H21F2N3O3/c1-3-12-29-26(33)17-6-5-16(4-2)19(14-17)25-21-8-10-24(30-31(21)13-11-22(25)32)34-23-9-7-18(27)15-20(23)28/h4-11,13-15H,2-3,12H2,1H3,(H,29,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars AffyNet	Article PubMed	n/a	n/a	53.5	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of mouse p38beta assessed as reduction in GST-ATF2 substrate phosphorylation by SPA assay				Bioorg Med Chem Lett 22: 5979-83 (2012)
					More data for this Ligand-Target Pair
MAP kinase p38 beta (Mus musculus (mouse))	BDBM50122915 (2-(2,6-Dichloro-phenyl)-6-[2-(2,4-difluoro-phenyl)...) Show SMILES Fc1ccc(-c2nc3ccccn3c2C2=NN(C(=O)CC2)c2c(Cl)cccc2Cl)c(F)c1 Show InChI InChI=1S/C23H14Cl2F2N4O/c24-15-4-3-5-16(25)22(15)31-20(32)10-9-18(29-31)23-21(14-8-7-13(26)12-17(14)27)28-19-6-1-2-11-30(19)23/h1-8,11-12H,9-10H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars AffyNet	Article PubMed	n/a	n/a	63	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of [gamma-33P]-ATP binding from active recombinant murine FLAG-Mitogen-activated protein kinase p38 beta fusion protein (GST-ATF2)				J Med Chem 46: 349-52 (2003)
					More data for this Ligand-Target Pair
MAP kinase p38 beta (Mus musculus (mouse))	BDBM50122922 (6-[2-(2-Chloro-4-fluoro-phenyl)-imidazo[1,2-a]pyri...) Show SMILES Fc1ccc(-c2nc3ccccn3c2-c2ccc(=O)n(n2)-c2c(Cl)cccc2Cl)c(Cl)c1 Show InChI InChI=1S/C23H12Cl3FN4O/c24-15-4-3-5-16(25)22(15)31-20(32)10-9-18(29-31)23-21(14-8-7-13(27)12-17(14)26)28-19-6-1-2-11-30(19)23/h1-12H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars AffyNet	Article PubMed	n/a	n/a	64	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of [gamma-33P]-ATP binding from active recombinant murine FLAG-Mitogen-activated protein kinase p38 beta fusion protein (GST-ATF2)				J Med Chem 46: 349-52 (2003)
					More data for this Ligand-Target Pair
MAP kinase p38 beta (Mus musculus (mouse))	BDBM50421139 (CHEMBL2088590) Show SMILES COc1ccc(cc1-c1c2ccc(Oc3ccc(F)cc3F)nn2ccc1=O)C(=O)NC1CC1 Show InChI InChI=1S/C25H19F2N3O4/c1-33-21-7-2-14(25(32)28-16-4-5-16)12-17(21)24-19-6-9-23(29-30(19)11-10-20(24)31)34-22-8-3-15(26)13-18(22)27/h2-3,6-13,16H,4-5H2,1H3,(H,28,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars AffyNet	Article PubMed	n/a	n/a	64	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of mouse p38beta assessed as reduction in GST-ATF2 substrate phosphorylation by SPA assay				Bioorg Med Chem Lett 22: 5979-83 (2012)
					More data for this Ligand-Target Pair
MAP kinase p38 beta (Mus musculus (mouse))	BDBM50421128 (CHEMBL2088583) Show SMILES Cc1nnc(o1)-c1ccc(F)c(c1)-c1c2ccc(Oc3ccc(F)cc3F)nn2ccc1=O Show InChI InChI=1S/C23H13F3N4O3/c1-12-27-28-23(32-12)13-2-4-16(25)15(10-13)22-18-5-7-21(29-30(18)9-8-19(22)31)33-20-6-3-14(24)11-17(20)26/h2-11H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars AffyNet	Article PubMed	n/a	n/a	66	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of mouse p38beta assessed as reduction in GST-ATF2 substrate phosphorylation by SPA assay				Bioorg Med Chem Lett 22: 5979-83 (2012)
					More data for this Ligand-Target Pair
MAP kinase p38 beta (Mus musculus (mouse))	BDBM50122914 (6-(2-(2,4-difluorophenyl)imidazo[1,2-a]pyridin-3-y...) Show SMILES Cc1ccccc1N1N=C(CCC1=O)c1c(nc2ccccn12)-c1ccc(F)cc1F Show InChI InChI=1S/C24H18F2N4O/c1-15-6-2-3-7-20(15)30-22(31)12-11-19(28-30)24-23(17-10-9-16(25)14-18(17)26)27-21-8-4-5-13-29(21)24/h2-10,13-14H,11-12H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars AffyNet	Article PubMed	n/a	n/a	78	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of [gamma-33P]-ATP binding from active recombinant murine FLAG-Mitogen-activated protein kinase p38 beta fusion protein (GST-ATF2)				J Med Chem 46: 349-52 (2003)
					More data for this Ligand-Target Pair
MAP kinase p38 beta (Mus musculus (mouse))	BDBM50421125 (CHEMBL2088586) Show SMILES Fc1ccc(Oc2ccc3c(-c4c(F)cccc4F)c(=O)ccn3n2)c(F)c1 Show InChI InChI=1S/C20H10F4N2O2/c21-11-4-6-17(14(24)10-11)28-18-7-5-15-20(16(27)8-9-26(15)25-18)19-12(22)2-1-3-13(19)23/h1-10H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars AffyNet	Article PubMed	n/a	n/a	86	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of mouse p38beta assessed as reduction in GST-ATF2 substrate phosphorylation by SPA assay				Bioorg Med Chem Lett 22: 5979-83 (2012)
					More data for this Ligand-Target Pair
MAP kinase p38 beta (Mus musculus (mouse))	BDBM50122908 (6-[2-(2-Chloro-4-fluoro-phenyl)-imidazo[1,2-a]pyri...) Show SMILES Cc1ccccc1N1N=C(CCC1=O)c1c(nc2ccccn12)-c1ccc(F)cc1Cl Show InChI InChI=1S/C24H18ClFN4O/c1-15-6-2-3-7-20(15)30-22(31)12-11-19(28-30)24-23(17-10-9-16(26)14-18(17)25)27-21-8-4-5-13-29(21)24/h2-10,13-14H,11-12H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars AffyNet	Article PubMed	n/a	n/a	94	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of [gamma-33P]-ATP binding from active recombinant murine FLAG-Mitogen-activated protein kinase p38 beta fusion protein (GST-ATF2)				J Med Chem 46: 349-52 (2003)
					More data for this Ligand-Target Pair
MAP kinase p38 beta (Mus musculus (mouse))	BDBM50421138 (CHEMBL2088589) Show SMILES CCCNC(=O)c1ccc(OC)c(c1)-c1c2ccc(Oc3ccc(F)cc3F)nn2ccc1=O Show InChI InChI=1S/C25H21F2N3O4/c1-3-11-28-25(32)15-4-7-21(33-2)17(13-15)24-19-6-9-23(29-30(19)12-10-20(24)31)34-22-8-5-16(26)14-18(22)27/h4-10,12-14H,3,11H2,1-2H3,(H,28,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars AffyNet	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of mouse p38beta assessed as reduction in GST-ATF2 substrate phosphorylation by SPA assay				Bioorg Med Chem Lett 22: 5979-83 (2012)
					More data for this Ligand-Target Pair
MAP kinase p38 beta (Mus musculus (mouse))	BDBM50122918 (2-(2,6-Dichloro-phenyl)-6-[2-(2,4-difluoro-phenyl)...) Show SMILES Fc1ccc(-c2nc3ccccn3c2-c2ccc(=O)n(n2)-c2c(Cl)cccc2Cl)c(F)c1 Show InChI InChI=1S/C23H12Cl2F2N4O/c24-15-4-3-5-16(25)22(15)31-20(32)10-9-18(29-31)23-21(14-8-7-13(26)12-17(14)27)28-19-6-1-2-11-30(19)23/h1-12H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars AffyNet	Article PubMed	n/a	n/a	112	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of [gamma-33P]-ATP binding from active recombinant murine FLAG-Mitogen-activated protein kinase p38 beta fusion protein (GST-ATF2)				J Med Chem 46: 349-52 (2003)
					More data for this Ligand-Target Pair
MAP Kinase p38 beta (Mus musculus (mouse))	BDBM16521 (2-arylpyridazin-3-one, 27 | 6-[(2-chloro-4-fluorop...) Show SMILES OCCN(c1ccc(=O)n(n1)-c1ccccc1Cl)c1ccc(F)cc1Cl Show InChI InChI=1S/C18H14Cl2FN3O2/c19-13-3-1-2-4-16(13)24-18(26)8-7-17(22-24)23(9-10-25)15-6-5-12(21)11-14(15)20/h1-8,11,25H,9-10H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	n/a	n/a	135	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...				Bioorg Med Chem Lett 16: 5809-13 (2006)
					More data for this Ligand-Target Pair
MAP kinase p38 beta (Mus musculus (mouse))	BDBM50421136 (CHEMBL2088587) Show SMILES COc1ccccc1-c1c2ccc(Oc3ccc(F)cc3F)nn2ccc1=O Show InChI InChI=1S/C21H14F2N2O3/c1-27-18-5-3-2-4-14(18)21-16-7-9-20(24-25(16)11-10-17(21)26)28-19-8-6-13(22)12-15(19)23/h2-12H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars AffyNet	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of mouse p38beta assessed as reduction in GST-ATF2 substrate phosphorylation by SPA assay				Bioorg Med Chem Lett 22: 5979-83 (2012)
					More data for this Ligand-Target Pair
MAP kinase p38 beta (Mus musculus (mouse))	BDBM50122913 (6-[2-(2,4-Difluoro-phenyl)-imidazo[1,2-a]pyridin-3...) Show SMILES Cc1ccccc1-n1nc(ccc1=O)-c1c(nc2ccccn12)-c1ccc(F)cc1F Show InChI InChI=1S/C24H16F2N4O/c1-15-6-2-3-7-20(15)30-22(31)12-11-19(28-30)24-23(17-10-9-16(25)14-18(17)26)27-21-8-4-5-13-29(21)24/h2-14H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars AffyNet	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of [gamma-33P]-ATP binding from active recombinant murine FLAG-Mitogen-activated protein kinase p38 beta fusion protein (GST-ATF2)				J Med Chem 46: 349-52 (2003)
					More data for this Ligand-Target Pair
MAP kinase p38 beta (Mus musculus (mouse))	BDBM50122910 (2-(2,6-Dichloro-phenyl)-6-[2-(4-fluoro-phenyl)-imi...) Show SMILES Fc1ccc(cc1)-c1nc2ccccn2c1-c1ccc(=O)n(n1)-c1c(Cl)cccc1Cl Show InChI InChI=1S/C23H13Cl2FN4O/c24-16-4-3-5-17(25)22(16)30-20(31)12-11-18(28-30)23-21(14-7-9-15(26)10-8-14)27-19-6-1-2-13-29(19)23/h1-13H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars AffyNet	Article PubMed	n/a	n/a	153	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of [gamma-33P]-ATP binding from active recombinant murine FLAG-Mitogen-activated protein kinase p38 beta fusion protein (GST-ATF2)				J Med Chem 46: 349-52 (2003)
					More data for this Ligand-Target Pair
MAP kinase p38 beta (Mus musculus (mouse))	BDBM50122923 (6-[2-(2-Chloro-4-fluoro-phenyl)-imidazo[1,2-a]pyri...) Show SMILES Fc1ccc(-c2nc3ccccn3c2-c2ccc(=O)n(n2)-c2ccccc2Cl)c(Cl)c1 Show InChI InChI=1S/C23H13Cl2FN4O/c24-16-5-1-2-6-19(16)30-21(31)11-10-18(28-30)23-22(15-9-8-14(26)13-17(15)25)27-20-7-3-4-12-29(20)23/h1-13H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars AffyNet	Article PubMed	n/a	n/a	171	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of [gamma-33P]-ATP binding from active recombinant murine FLAG-Mitogen-activated protein kinase p38 beta fusion protein (GST-ATF2)				J Med Chem 46: 349-52 (2003)
					More data for this Ligand-Target Pair
MAP kinase p38 beta (Mus musculus (mouse))	BDBM50421134 (CHEMBL2088576) Show SMILES CCCNC(=O)c1ccc(CC)c(c1)-c1c2ccc(Oc3ccc(F)cc3F)nn2ccc1=O Show InChI InChI=1S/C26H23F2N3O3/c1-3-12-29-26(33)17-6-5-16(4-2)19(14-17)25-21-8-10-24(30-31(21)13-11-22(25)32)34-23-9-7-18(27)15-20(23)28/h5-11,13-15H,3-4,12H2,1-2H3,(H,29,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars AffyNet	Article PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of mouse p38beta assessed as reduction in GST-ATF2 substrate phosphorylation by SPA assay				Bioorg Med Chem Lett 22: 5979-83 (2012)
					More data for this Ligand-Target Pair
MAP kinase p38 beta (Mus musculus (mouse))	BDBM50421130 (CHEMBL2088580) Show SMILES Fc1ccc(Oc2ccc3c(-c4cc(ccc4F)C(=O)NC4CC4)c(=O)ccn3n2)c(F)c1 Show InChI InChI=1S/C24H16F3N3O3/c25-14-2-7-21(18(27)12-14)33-22-8-6-19-23(20(31)9-10-30(19)29-22)16-11-13(1-5-17(16)26)24(32)28-15-3-4-15/h1-2,5-12,15H,3-4H2,(H,28,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars AffyNet	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of mouse p38beta assessed as reduction in GST-ATF2 substrate phosphorylation by SPA assay				Bioorg Med Chem Lett 22: 5979-83 (2012)
					More data for this Ligand-Target Pair
MAP Kinase p38 beta (Mus musculus (mouse))	BDBM16522 (2-arylpyridazin-3-one, 28 | 6-[(3-aminopropyl)(2-c...) Show SMILES NCCCN(c1ccc(=O)n(n1)-c1ccccc1Cl)c1ccccc1Cl Show InChI InChI=1S/C19H18Cl2N4O/c20-14-6-1-3-8-16(14)24(13-5-12-22)18-10-11-19(26)25(23-18)17-9-4-2-7-15(17)21/h1-4,6-11H,5,12-13,22H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	Article PubMed	n/a	n/a	211	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...				Bioorg Med Chem Lett 16: 5809-13 (2006)
					More data for this Ligand-Target Pair
MAP kinase p38 beta (Mus musculus (mouse))	BDBM50421135 (CHEMBL2088577) Show SMILES CCc1ccc(cc1-c1c2ccc(Oc3ccc(F)cc3F)nn2ccc1=O)C(=O)NC1CC1 Show InChI InChI=1S/C26H21F2N3O3/c1-2-15-3-4-16(26(33)29-18-6-7-18)13-19(15)25-21-8-10-24(30-31(21)12-11-22(25)32)34-23-9-5-17(27)14-20(23)28/h3-5,8-14,18H,2,6-7H2,1H3,(H,29,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars AffyNet	Article PubMed	n/a	n/a	230	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of mouse p38beta assessed as reduction in GST-ATF2 substrate phosphorylation by SPA assay				Bioorg Med Chem Lett 22: 5979-83 (2012)
					More data for this Ligand-Target Pair
MAP kinase p38 beta (Mus musculus (mouse))	BDBM50421126 (CHEMBL2088585) Show SMILES Fc1ccc(Oc2ccc3c(-c4ccccc4F)c(=O)ccn3n2)c(F)c1 Show InChI InChI=1S/C20H11F3N2O2/c21-12-5-7-18(15(23)11-12)27-19-8-6-16-20(13-3-1-2-4-14(13)22)17(26)9-10-25(16)24-19/h1-11H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars AffyNet	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of mouse p38beta assessed as reduction in GST-ATF2 substrate phosphorylation by SPA assay				Bioorg Med Chem Lett 22: 5979-83 (2012)
					More data for this Ligand-Target Pair
MAP kinase p38 beta (Mus musculus (mouse))	BDBM50122921 (2-(2-Chloro-phenyl)-6-[2-(3-trifluoromethyl-phenyl...) Show SMILES FC(F)(F)c1cccc(c1)-c1nc2ccccn2c1C1=NN(C(=O)CC1)c1ccccc1Cl Show InChI InChI=1S/C24H16ClF3N4O/c25-17-8-1-2-9-19(17)32-21(33)12-11-18(30-32)23-22(29-20-10-3-4-13-31(20)23)15-6-5-7-16(14-15)24(26,27)28/h1-10,13-14H,11-12H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars AffyNet	Article PubMed	n/a	n/a	355	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of [gamma-33P]-ATP binding from active recombinant murine FLAG-Mitogen-activated protein kinase p38 beta fusion protein (GST-ATF2)				J Med Chem 46: 349-52 (2003)
					More data for this Ligand-Target Pair
MAP kinase p38 beta (Mus musculus (mouse))	BDBM50421129 (CHEMBL2088584) Show SMILES CCCNC(=O)c1ccc(F)c(c1)-c1c2ccc(Oc3ccc(F)cc3F)nn2ccc1=O Show InChI InChI=1S/C24H18F3N3O3/c1-2-10-28-24(32)14-3-5-17(26)16(12-14)23-19-6-8-22(29-30(19)11-9-20(23)31)33-21-7-4-15(25)13-18(21)27/h3-9,11-13H,2,10H2,1H3,(H,28,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars AffyNet	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of mouse p38beta assessed as reduction in GST-ATF2 substrate phosphorylation by SPA assay				Bioorg Med Chem Lett 22: 5979-83 (2012)
					More data for this Ligand-Target Pair
MAP Kinase p38 beta (Mus musculus (mouse))	BDBM16515 (2-(2-chlorophenyl)-6-[(2-methylphenyl)amino]-2,3-d...) Show SMILES Cc1ccccc1Nc1ccc(=O)n(n1)-c1ccccc1Cl Show InChI InChI=1S/C17H14ClN3O/c1-12-6-2-4-8-14(12)19-16-10-11-17(22)21(20-16)15-9-5-3-7-13(15)18/h2-11H,1H3,(H,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	Article PubMed	n/a	n/a	450	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...				Bioorg Med Chem Lett 16: 5809-13 (2006)
					More data for this Ligand-Target Pair
MAP Kinase p38 beta (Mus musculus (mouse))	BDBM16517 (2-(2-chlorophenyl)-6-[(2-fluorophenyl)sulfanyl]-2,...) Show SMILES Fc1ccccc1Sc1ccc(=O)n(n1)-c1ccccc1Cl Show InChI InChI=1S/C16H10ClFN2OS/c17-11-5-1-3-7-13(11)20-16(21)10-9-15(19-20)22-14-8-4-2-6-12(14)18/h1-10H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	Article PubMed	n/a	n/a	450	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...				Bioorg Med Chem Lett 16: 5809-13 (2006)
					More data for this Ligand-Target Pair
MAP Kinase p38 beta (Mus musculus (mouse))	BDBM16523 (2-(2-chlorophenyl)-6-[(2-chlorophenyl)(3-{[(2,3,4-...) Show SMILES COc1ccc(CNCCCN(c2ccc(=O)n(n2)-c2ccccc2Cl)c2ccccc2Cl)c(OC)c1OC Show InChI InChI=1S/C29H30Cl2N4O4/c1-37-25-14-13-20(28(38-2)29(25)39-3)19-32-17-8-18-34(23-11-6-4-9-21(23)30)26-15-16-27(36)35(33-26)24-12-7-5-10-22(24)31/h4-7,9-16,32H,8,17-19H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...				Bioorg Med Chem Lett 16: 5809-13 (2006)
					More data for this Ligand-Target Pair
MAP kinase p38 beta (Mus musculus (mouse))	BDBM50122911 (6-[2-(2-Chloro-4-fluoro-phenyl)-imidazo[1,2-a]pyri...) Show SMILES Fc1ccc(-c2nc3ccccn3c2C2=NN(C(=O)CC2)c2c(Cl)cccc2Cl)c(Cl)c1 Show InChI InChI=1S/C23H14Cl3FN4O/c24-15-4-3-5-16(25)22(15)31-20(32)10-9-18(29-31)23-21(14-8-7-13(27)12-17(14)26)28-19-6-1-2-11-30(19)23/h1-8,11-12H,9-10H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars AffyNet	Article PubMed	n/a	n/a	670	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of [gamma-33P]-ATP binding from active recombinant murine FLAG-Mitogen-activated protein kinase p38 beta fusion protein (GST-ATF2)				J Med Chem 46: 349-52 (2003)
					More data for this Ligand-Target Pair
MAP Kinase p38 beta (Mus musculus (mouse))	BDBM16518 (2-(4-chloro-2-methylphenyl)-6-[(2,4-difluorophenyl...) Show SMILES Cc1cc(Cl)ccc1-n1nc(Sc2ccc(F)cc2F)ccc1=O Show InChI InChI=1S/C17H11ClF2N2OS/c1-10-8-11(18)2-4-14(10)22-17(23)7-6-16(21-22)24-15-5-3-12(19)9-13(15)20/h2-9H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	Article PubMed	n/a	n/a	850	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...				Bioorg Med Chem Lett 16: 5809-13 (2006)
					More data for this Ligand-Target Pair
MAP kinase p38 beta (Mus musculus (mouse))	BDBM50122912 (2-(2,6-Dichloro-phenyl)-6-[2-(2,3-dichloro-phenyl)...) Show SMILES Clc1cccc(-c2nc3ccccn3c2-c2ccc(=O)n(n2)-c2c(Cl)cccc2Cl)c1Cl Show InChI InChI=1S/C23H12Cl4N4O/c24-14-6-3-5-13(20(14)27)21-23(30-12-2-1-9-18(30)28-21)17-10-11-19(32)31(29-17)22-15(25)7-4-8-16(22)26/h1-12H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars AffyNet	Article PubMed	n/a	n/a	890	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of [gamma-33P]-ATP binding from active recombinant murine FLAG-Mitogen-activated protein kinase p38 beta fusion protein (GST-ATF2)				J Med Chem 46: 349-52 (2003)
					More data for this Ligand-Target Pair
MAP Kinase p38 beta (Mus musculus (mouse))	BDBM16516 (2-(2-chlorophenyl)-6-[(2-methoxyphenyl)amino]-2,3-...) Show SMILES COc1ccccc1Nc1ccc(=O)n(n1)-c1ccccc1Cl Show InChI InChI=1S/C17H14ClN3O2/c1-23-15-9-5-3-7-13(15)19-16-10-11-17(22)21(20-16)14-8-4-2-6-12(14)18/h2-11H,1H3,(H,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	Article PubMed	n/a	n/a	920	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...				Bioorg Med Chem Lett 16: 5809-13 (2006)
					More data for this Ligand-Target Pair
MAP Kinase p38 beta (Mus musculus (mouse))	BDBM16513 (2-(2-chlorophenyl)-6-[(2-chlorophenyl)amino]-2,3-d...) Show SMILES Clc1ccccc1Nc1ccc(=O)n(n1)-c1ccccc1Cl Show InChI InChI=1S/C16H11Cl2N3O/c17-11-5-1-3-7-13(11)19-15-9-10-16(22)21(20-15)14-8-4-2-6-12(14)18/h1-10H,(H,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars AffyNet	Article PubMed	n/a	n/a	990	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...				Bioorg Med Chem Lett 16: 5809-13 (2006)
					More data for this Ligand-Target Pair
MAP kinase p38 beta (Mus musculus (mouse))	BDBM50122919 (6-[2-(2-Chloro-4-fluoro-phenyl)-imidazo[1,2-a]pyri...) Show SMILES Fc1ccc(-c2nc3ccccn3c2C2=NN(C(=O)CC2)c2ccccc2Cl)c(Cl)c1 Show InChI InChI=1S/C23H15Cl2FN4O/c24-16-5-1-2-6-19(16)30-21(31)11-10-18(28-30)23-22(15-9-8-14(26)13-17(15)25)27-20-7-3-4-12-29(20)23/h1-9,12-13H,10-11H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars AffyNet	Article PubMed	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of [gamma-33P]-ATP binding from active recombinant murine FLAG-Mitogen-activated protein kinase p38 beta fusion protein (GST-ATF2)				J Med Chem 46: 349-52 (2003)
					More data for this Ligand-Target Pair
MAP kinase p38 beta (Mus musculus (mouse))	BDBM50421131 (CHEMBL2088581) Show SMILES Fc1ccc(Oc2ccc3c(-c4cc(ccc4F)C(=O)N4CCCC4)c(=O)ccn3n2)c(F)c1 Show InChI InChI=1S/C25H18F3N3O3/c26-16-4-7-22(19(28)14-16)34-23-8-6-20-24(21(32)9-12-31(20)29-23)17-13-15(3-5-18(17)27)25(33)30-10-1-2-11-30/h3-9,12-14H,1-2,10-11H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars AffyNet	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of mouse p38beta assessed as reduction in GST-ATF2 substrate phosphorylation by SPA assay				Bioorg Med Chem Lett 22: 5979-83 (2012)
					More data for this Ligand-Target Pair