BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 249 hits Enz. Inhib. hit(s) with Target = 'MAP kinase ERK1'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM120095
PNG
(US8697715, 39 | US9259470, 39)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1ccn([C@H](CO)c2ccc(Cl)c(F)c2)c(=O)c1
Show InChI InChI=1S/C21H18ClFN6O2/c1-28-19(5-8-25-28)27-21-24-7-4-17(26-21)13-6-9-29(20(31)11-13)18(12-30)14-2-3-15(22)16(23)10-14/h2-11,18,30H,12H2,1H3,(H,24,26,27)/t18-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
PDB
UniChem

Similars

AffyNet 
PDB
PubMed
n/an/a 1.20n/an/an/an/an/an/a



Ontario Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of ERK1 (unknown origin)


Bioorg Med Chem Lett 25: 4047-56 (2015)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50094464
PNG
(CHEMBL3590107)
Show SMILES O=C(CN1CC[C@H](C1)C(=O)Nc1ccc2[nH]nc(-c3ccncc3)c2c1)N1CCN(CC1)c1ccc(cc1)-c1ncccn1
Show InChI InChI=1S/C22H27NO3/c1-2-15-23-16-13-20(14-17-23)26-21(24)22(25,18-9-5-3-6-10-18)19-11-7-4-8-12-19/h3-12,20,25H,2,13-17H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 4n/an/an/an/an/an/a



Ontario Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of ERK1 (unknown origin) after 45 mins by IMAP assay


Bioorg Med Chem Lett 25: 4047-56 (2015)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM103302
PNG
(SCH772984 | US8546404, 6)
Show SMILES O=C(CN1CC[C@@H](C1)C(=O)Nc1ccc2[nH]nc(-c3ccncc3)c2c1)N1CCN(CC1)c1ccc(cc1)-c1ncccn1
Show InChI InChI=1S/C33H33N9O2/c43-30(42-18-16-41(17-19-42)27-5-2-24(3-6-27)32-35-11-1-12-36-32)22-40-15-10-25(21-40)33(44)37-26-4-7-29-28(20-26)31(39-38-29)23-8-13-34-14-9-23/h1-9,11-14,20,25H,10,15-19,21-22H2,(H,37,44)(H,38,39)/t25-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 8.30n/an/an/an/an/an/a



George Washington University



Assay Description
The IC50 values of selected kinases were determined using either Z'LYTE, Adapta or LanthaScreen assays.


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50166412
PNG
(CHEMBL3797917)
Show InChI InChI=1S/C20H14Cl3N5O/c1-10-6-11(4-5-24-10)18-13-7-12(2-3-16(13)27-28-18)20(29)26-8-14-15(21)9-25-19(23)17(14)22/h2-7,9H,8H2,1H3,(H,26,29)(H,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 17n/an/an/an/an/an/a



Green Valley Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-tagged ERK1 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM16673
PNG
(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1
Show InChI InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 18n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK1 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50166572
PNG
(CHEMBL3798624)
Show SMILES C[C@H](NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1)c1c(Cl)cccc1Cl
Show InChI InChI=1/C22H18Cl2N4O/c1-12-10-14(8-9-25-12)21-16-11-15(6-7-19(16)27-28-21)22(29)26-13(2)20-17(23)4-3-5-18(20)24/h3-11,13H,1-2H3,(H,26,29)(H,27,28)/t13-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 19n/an/an/an/an/an/a



Green Valley Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-tagged ERK1 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50088859
PNG
(CHEMBL3577565)
Show SMILES COc1cccc(c1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3cccc(C)c3)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C32H27N3O4/c1-22-8-6-11-25(18-22)33-30(36)21-39-27-16-14-23(15-17-27)19-29-32(37)35(26-12-7-13-28(20-26)38-2)31(34-29)24-9-4-3-5-10-24/h3-20H,21H2,1-2H3,(H,33,36)/b29-19-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 20n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK1 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50089077
PNG
(CHEMBL3577641)
Show SMILES COc1ccc(cc1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3cccc(OC)c3)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C32H27N3O5/c1-38-26-17-13-25(14-18-26)35-31(23-7-4-3-5-8-23)34-29(32(35)37)19-22-11-15-27(16-12-22)40-21-30(36)33-24-9-6-10-28(20-24)39-2/h3-20H,21H2,1-2H3,(H,33,36)/b29-19-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 21n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK1 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50166413
PNG
(CHEMBL3799117)
Show SMILES CC(NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1)c1c(Cl)cnc(Cl)c1Cl
Show InChI InChI=1/C21H16Cl3N5O/c1-10-7-12(5-6-25-10)19-14-8-13(3-4-16(14)28-29-19)21(30)27-11(2)17-15(22)9-26-20(24)18(17)23/h3-9,11H,1-2H3,(H,27,30)(H,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 22n/an/an/an/an/an/a



Green Valley Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-tagged ERK1 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50089082
PNG
(CHEMBL3577636)
Show SMILES COc1ccc(cc1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3ccccc3)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C31H25N3O4/c1-37-26-18-14-25(15-19-26)34-30(23-8-4-2-5-9-23)33-28(31(34)36)20-22-12-16-27(17-13-22)38-21-29(35)32-24-10-6-3-7-11-24/h2-20H,21H2,1H3,(H,32,35)/b28-20-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 23n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK1 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50089076
PNG
(CHEMBL3577642)
Show SMILES COc1ccc(NC(=O)COc2ccc(\C=C3/N=C(N(C3=O)c3ccc(OC)cc3)c3ccccc3)cc2)cc1
Show InChI InChI=1S/C32H27N3O5/c1-38-26-16-10-24(11-17-26)33-30(36)21-40-28-14-8-22(9-15-28)20-29-32(37)35(25-12-18-27(39-2)19-13-25)31(34-29)23-6-4-3-5-7-23/h3-20H,21H2,1-2H3,(H,33,36)/b29-20-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 23n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK1 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50089079
PNG
(CHEMBL3577639)
Show SMILES COc1ccc(cc1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3ccc(C)cc3)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C32H27N3O4/c1-22-8-12-25(13-9-22)33-30(36)21-39-28-16-10-23(11-17-28)20-29-32(37)35(26-14-18-27(38-2)19-15-26)31(34-29)24-6-4-3-5-7-24/h3-20H,21H2,1-2H3,(H,33,36)/b29-20-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 23n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK1 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50089074
PNG
(CHEMBL3577643)
Show SMILES COc1ccc(cc1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3ccccc3Cl)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C31H24ClN3O4/c1-38-24-17-13-23(14-18-24)35-30(22-7-3-2-4-8-22)34-28(31(35)37)19-21-11-15-25(16-12-21)39-20-29(36)33-27-10-6-5-9-26(27)32/h2-19H,20H2,1H3,(H,33,36)/b28-19-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 24n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK1 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50088858
PNG
(CHEMBL3577566)
Show SMILES COc1cccc(c1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3ccc(C)cc3)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C32H27N3O4/c1-22-11-15-25(16-12-22)33-30(36)21-39-27-17-13-23(14-18-27)19-29-32(37)35(26-9-6-10-28(20-26)38-2)31(34-29)24-7-4-3-5-8-24/h3-20H,21H2,1-2H3,(H,33,36)/b29-19-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 25n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK1 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50166568
PNG
(CHEMBL3799614)
Show SMILES Clc1cc(CNC(=O)c2ccc3[nH]nc(-c4ccncc4)c3c2)ccn1
Show InChI InChI=1S/C19H14ClN5O/c20-17-9-12(3-8-22-17)11-23-19(26)14-1-2-16-15(10-14)18(25-24-16)13-4-6-21-7-5-13/h1-10H,11H2,(H,23,26)(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 26n/an/an/an/an/an/a



Green Valley Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-tagged ERK1 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50166408
PNG
(CHEMBL3797756)
Show SMILES OC[C@@H](NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)c1cccc(Cl)c1
Show InChI InChI=1/C21H17ClN4O2/c22-16-3-1-2-14(10-16)19(12-27)24-21(28)15-4-5-18-17(11-15)20(26-25-18)13-6-8-23-9-7-13/h1-11,19,27H,12H2,(H,24,28)(H,25,26)/t19-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 26n/an/an/an/an/an/a



Green Valley Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-tagged ERK1 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50166569
PNG
(CHEMBL3798257)
Show SMILES CC(NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1)c1c(Cl)cncc1Cl
Show InChI InChI=1/C21H17Cl2N5O/c1-11-7-13(5-6-25-11)20-15-8-14(3-4-18(15)27-28-20)21(29)26-12(2)19-16(22)9-24-10-17(19)23/h3-10,12H,1-2H3,(H,26,29)(H,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 29n/an/an/an/an/an/a



Green Valley Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-tagged ERK1 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50166411
PNG
(CHEMBL3799113)
Show InChI InChI=1S/C20H13Cl2FN4O/c21-15-3-1-13(17(22)18(15)23)10-25-20(28)12-2-4-16-14(9-12)19(27-26-16)11-5-7-24-8-6-11/h1-9H,10H2,(H,25,28)(H,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 29n/an/an/an/an/an/a



Green Valley Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-tagged ERK1 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50166430
PNG
(CHEMBL3798692)
Show SMILES CC(NC(=O)c1ccc2[nH]nc(-c3cc(F)c(O)c(F)c3)c2c1)c1cccc(Cl)c1
Show InChI InChI=1/C22H16ClF2N3O2/c1-11(12-3-2-4-15(23)7-12)26-22(30)13-5-6-19-16(8-13)20(28-27-19)14-9-17(24)21(29)18(25)10-14/h2-11,29H,1H3,(H,26,30)(H,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 32n/an/an/an/an/an/a



Green Valley Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-tagged ERK1 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50089081
PNG
(CHEMBL3577637)
Show SMILES COc1ccc(cc1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3ccccc3C)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C32H27N3O4/c1-22-8-6-7-11-28(22)33-30(36)21-39-27-16-12-23(13-17-27)20-29-32(37)35(25-14-18-26(38-2)19-15-25)31(34-29)24-9-4-3-5-10-24/h3-20H,21H2,1-2H3,(H,33,36)/b29-20-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 32n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK1 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50088897
PNG
(CHEMBL3577644)
Show SMILES COc1ccc(cc1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3cccc(Cl)c3)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C31H24ClN3O4/c1-38-26-16-12-25(13-17-26)35-30(22-6-3-2-4-7-22)34-28(31(35)37)18-21-10-14-27(15-11-21)39-20-29(36)33-24-9-5-8-23(32)19-24/h2-19H,20H2,1H3,(H,33,36)/b28-18-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 35n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK1 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50166409
PNG
(CHEMBL3797587)
Show InChI InChI=1/C21H17ClN4O/c1-13(16-4-2-3-5-18(16)22)24-21(27)15-6-7-19-17(12-15)20(26-25-19)14-8-10-23-11-9-14/h2-13H,1H3,(H,24,27)(H,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 36n/an/an/an/an/an/a



Green Valley Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-tagged ERK1 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50166324
PNG
(CHEMBL3798163)
Show SMILES O=C(NCCc1ccccc1)c1ccc2[nH]nc(-c3ccncc3)c2c1
Show InChI InChI=1S/C21H18N4O/c26-21(23-13-8-15-4-2-1-3-5-15)17-6-7-19-18(14-17)20(25-24-19)16-9-11-22-12-10-16/h1-7,9-12,14H,8,13H2,(H,23,26)(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 39n/an/an/an/an/an/a



Green Valley Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-tagged ERK1 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50088894
PNG
(CHEMBL3577564)
Show SMILES COc1cccc(c1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3ccccc3C)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C32H27N3O4/c1-22-9-6-7-14-28(22)33-30(36)21-39-26-17-15-23(16-18-26)19-29-32(37)35(25-12-8-13-27(20-25)38-2)31(34-29)24-10-4-3-5-11-24/h3-20H,21H2,1-2H3,(H,33,36)/b29-19-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 43n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK1 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50166290
PNG
(CHEMBL3798926)
Show SMILES O=C(NCCCc1ccccc1)c1ccc2[nH]nc(-c3ccncc3)c2c1
Show InChI InChI=1S/C22H20N4O/c27-22(24-12-4-7-16-5-2-1-3-6-16)18-8-9-20-19(15-18)21(26-25-20)17-10-13-23-14-11-17/h1-3,5-6,8-11,13-15H,4,7,12H2,(H,24,27)(H,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 43n/an/an/an/an/an/a



Green Valley Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-tagged ERK1 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50089078
PNG
(CHEMBL3577640)
Show SMILES COc1ccc(cc1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3ccccc3OC)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C32H27N3O5/c1-38-25-18-14-24(15-19-25)35-31(23-8-4-3-5-9-23)34-28(32(35)37)20-22-12-16-26(17-13-22)40-21-30(36)33-27-10-6-7-11-29(27)39-2/h3-20H,21H2,1-2H3,(H,33,36)/b28-20-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 43n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK1 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50166410
PNG
(CHEMBL3800263)
Show SMILES Clc1ccccc1CNC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1
Show InChI InChI=1S/C20H15ClN4O/c21-17-4-2-1-3-15(17)12-23-20(26)14-5-6-18-16(11-14)19(25-24-18)13-7-9-22-10-8-13/h1-11H,12H2,(H,23,26)(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 46n/an/an/an/an/an/a



Green Valley Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-tagged ERK1 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50088857
PNG
(CHEMBL3577567)
Show SMILES COc1cccc(c1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3ccccc3OC)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C32H27N3O5/c1-38-26-12-8-11-24(20-26)35-31(23-9-4-3-5-10-23)34-28(32(35)37)19-22-15-17-25(18-16-22)40-21-30(36)33-27-13-6-7-14-29(27)39-2/h3-20H,21H2,1-2H3,(H,33,36)/b28-19-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 46n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK1 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50088896
PNG
(CHEMBL3577645)
Show SMILES COc1ccc(cc1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3ccc(Cl)cc3)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C31H24ClN3O4/c1-38-26-17-13-25(14-18-26)35-30(22-5-3-2-4-6-22)34-28(31(35)37)19-21-7-15-27(16-8-21)39-20-29(36)33-24-11-9-23(32)10-12-24/h2-19H,20H2,1H3,(H,33,36)/b28-19-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 47n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK1 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50166427
PNG
(CHEMBL3798015)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC(CO)c1cccc(Cl)c1
Show InChI InChI=1/C22H19ClN4O2/c1-13-9-15(7-8-24-13)21-18-11-16(5-6-19(18)26-27-21)22(29)25-20(12-28)14-3-2-4-17(23)10-14/h2-11,20,28H,12H2,1H3,(H,25,29)(H,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 53n/an/an/an/an/an/a



Green Valley Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-tagged ERK1 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50166567
PNG
(CHEMBL3797242)
Show SMILES Clc1cncc(Cl)c1CNC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1
Show InChI InChI=1S/C19H13Cl2N5O/c20-15-9-23-10-16(21)14(15)8-24-19(27)12-1-2-17-13(7-12)18(26-25-17)11-3-5-22-6-4-11/h1-7,9-10H,8H2,(H,24,27)(H,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 56n/an/an/an/an/an/a



Green Valley Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-tagged ERK1 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50088856
PNG
(CHEMBL3577631)
Show SMILES COc1cccc(NC(=O)COc2ccc(\C=C3/N=C(N(C3=O)c3cccc(OC)c3)c3ccccc3)cc2)c1
Show InChI InChI=1S/C32H27N3O5/c1-38-27-12-6-10-24(19-27)33-30(36)21-40-26-16-14-22(15-17-26)18-29-32(37)35(25-11-7-13-28(20-25)39-2)31(34-29)23-8-4-3-5-9-23/h3-20H,21H2,1-2H3,(H,33,36)/b29-18-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 57n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK1 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50088895
PNG
(CHEMBL3577563)
Show SMILES COc1cccc(c1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3ccccc3)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C31H25N3O4/c1-37-27-14-8-13-25(20-27)34-30(23-9-4-2-5-10-23)33-28(31(34)36)19-22-15-17-26(18-16-22)38-21-29(35)32-24-11-6-3-7-12-24/h2-20H,21H2,1H3,(H,32,35)/b28-19-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 65n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK1 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50166429
PNG
(CHEMBL3797827)
Show SMILES Nc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC(CO)c1cccc(Cl)c1
Show InChI InChI=1/C21H18ClN5O2/c22-15-3-1-2-12(8-15)18(11-28)25-21(29)14-4-5-17-16(9-14)20(27-26-17)13-6-7-24-19(23)10-13/h1-10,18,28H,11H2,(H2,23,24)(H,25,29)(H,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 67n/an/an/an/an/an/a



Green Valley Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-tagged ERK1 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50166424
PNG
(CHEMBL3800134)
Show SMILES OCC(NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)c1cccc(Cl)c1
Show InChI InChI=1/C21H17ClN4O2/c22-16-3-1-2-14(10-16)19(12-27)24-21(28)15-4-5-18-17(11-15)20(26-25-18)13-6-8-23-9-7-13/h1-11,19,27H,12H2,(H,24,28)(H,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 72n/an/an/an/an/an/a



Green Valley Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-tagged ERK1 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50166349
PNG
(CHEMBL3799716)
Show SMILES Clc1cccc(CNC(=O)c2ccc3[nH]nc(-c4ccncc4)c3c2)c1
Show InChI InChI=1S/C42H44N6O6/c43-35(23-29-11-19-33(49)20-12-29)39(51)47-37(25-27-7-3-1-4-8-27)41(53)45-31-15-17-32(18-16-31)46-42(54)38(26-28-9-5-2-6-10-28)48-40(52)36(44)24-30-13-21-34(50)22-14-30/h1-22,35-38,49-50H,23-26,43-44H2,(H,45,53)(H,46,54)(H,47,51)(H,48,52)/t35-,36-,37-,38-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 74n/an/an/an/an/an/a



Green Valley Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-tagged ERK1 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50088855
PNG
(CHEMBL3577632)
Show SMILES COc1ccc(NC(=O)COc2ccc(\C=C3/N=C(N(C3=O)c3cccc(OC)c3)c3ccccc3)cc2)cc1
Show InChI InChI=1S/C32H27N3O5/c1-38-26-17-13-24(14-18-26)33-30(36)21-40-27-15-11-22(12-16-27)19-29-32(37)35(25-9-6-10-28(20-25)39-2)31(34-29)23-7-4-3-5-8-23/h3-20H,21H2,1-2H3,(H,33,36)/b29-19-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 76n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK1 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50166352
PNG
(CHEMBL3800189)
Show SMILES CCC(NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)c1cccc(Cl)c1
Show InChI InChI=1S/C42H44N6O6/c43-33(23-29-15-19-31(49)20-16-29)39(51)47-37(25-27-9-3-1-4-10-27)41(53)45-35-13-7-8-14-36(35)46-42(54)38(26-28-11-5-2-6-12-28)48-40(52)34(44)24-30-17-21-32(50)22-18-30/h1-22,33-34,37-38,49-50H,23-26,43-44H2,(H,45,53)(H,46,54)(H,47,51)(H,48,52)/t33-,34-,37-,38-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 79n/an/an/an/an/an/a



Green Valley Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-tagged ERK1 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50088854
PNG
(CHEMBL3577633)
Show SMILES COc1cccc(c1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3ccccc3Cl)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C31H24ClN3O4/c1-38-25-11-7-10-23(19-25)35-30(22-8-3-2-4-9-22)34-28(31(35)37)18-21-14-16-24(17-15-21)39-20-29(36)33-27-13-6-5-12-26(27)32/h2-19H,20H2,1H3,(H,33,36)/b28-18-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 87n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK1 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50088791
PNG
(CHEMBL3577634)
Show SMILES COc1cccc(c1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3cccc(Cl)c3)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C31H24ClN3O4/c1-38-27-12-6-11-25(19-27)35-30(22-7-3-2-4-8-22)34-28(31(35)37)17-21-13-15-26(16-14-21)39-20-29(36)33-24-10-5-9-23(32)18-24/h2-19H,20H2,1H3,(H,33,36)/b28-17-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 89n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK1 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50089080
PNG
(CHEMBL3577638)
Show SMILES COc1ccc(cc1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3cccc(C)c3)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C32H27N3O4/c1-22-7-6-10-25(19-22)33-30(36)21-39-28-15-11-23(12-16-28)20-29-32(37)35(26-13-17-27(38-2)18-14-26)31(34-29)24-8-4-3-5-9-24/h3-20H,21H2,1-2H3,(H,33,36)/b29-20-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 89n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK1 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50089083
PNG
(CHEMBL3577635)
Show SMILES COc1cccc(c1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3ccc(Cl)cc3)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C31H24ClN3O4/c1-38-27-9-5-8-25(19-27)35-30(22-6-3-2-4-7-22)34-28(31(35)37)18-21-10-16-26(17-11-21)39-20-29(36)33-24-14-12-23(32)13-15-24/h2-19H,20H2,1H3,(H,33,36)/b28-18-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 95n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK1 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50166331
PNG
(CHEMBL3798109)
Show InChI InChI=1S/C20H16N4O/c25-20(22-13-14-4-2-1-3-5-14)16-6-7-18-17(12-16)19(24-23-18)15-8-10-21-11-9-15/h1-12H,13H2,(H,22,25)(H,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 106n/an/an/an/an/an/a



Green Valley Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-tagged ERK1 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50166428
PNG
(CHEMBL3799983)
Show SMILES OCC(NC(=O)c1ccc2[nH]nc(-c3ccc(O)c(F)c3)c2c1)c1cccc(Cl)c1
Show InChI InChI=1/C22H17ClFN3O3/c23-15-3-1-2-12(8-15)19(11-28)25-22(30)14-4-6-18-16(9-14)21(27-26-18)13-5-7-20(29)17(24)10-13/h1-10,19,28-29H,11H2,(H,25,30)(H,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 111n/an/an/an/an/an/a



Green Valley Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-tagged ERK1 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50166322
PNG
(CHEMBL3797548)
Show SMILES CC(CNC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)Oc1ccccc1
Show InChI InChI=1/C22H20N4O2/c1-15(28-18-5-3-2-4-6-18)14-24-22(27)17-7-8-20-19(13-17)21(26-25-20)16-9-11-23-12-10-16/h2-13,15H,14H2,1H3,(H,24,27)(H,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 128n/an/an/an/an/an/a



Green Valley Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-tagged ERK1 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50166350
PNG
(CHEMBL3798631)
Show SMILES CC(NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1)c1cccc(Cl)c1
Show InChI InChI=1/C21H17ClN4O/c1-13(15-3-2-4-17(22)11-15)24-21(27)16-5-6-19-18(12-16)20(26-25-19)14-7-9-23-10-8-14/h2-13H,1H3,(H,24,27)(H,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 154n/an/an/an/an/an/a



Green Valley Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-tagged ERK1 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50164696
PNG
(CHEMBL195641 | N*4*-[4-(3H-Benzoimidazol-5-ylamino...)
Show SMILES FC(F)(F)c1cnc(Nc2ccc(NC#N)c(NC#N)c2)nc1Nc1ccc2nc[nH]c2c1
Show InChI InChI=1S/C20H13F3N10/c21-20(22,23)13-7-26-19(32-12-2-3-14(27-8-24)16(6-12)28-9-25)33-18(13)31-11-1-4-15-17(5-11)30-10-29-15/h1-7,10,27-28H,(H,29,30)(H2,26,31,32,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 300n/an/an/an/an/an/a



Bayer Research Center

Curated by ChEMBL


Assay Description
Inhibitory concentration against Extracellular signal-regulated kinase 1


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50188913
PNG
(CHEMBL213618 | N-((S)-1-amino-3-(2,4-dichloropheny...)
Show SMILES CNc1nccc(n1)-c1ccc(s1)C(=O)N[C@H](CN)Cc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C19H19Cl2N5OS/c1-23-19-24-7-6-15(26-19)16-4-5-17(28-16)18(27)25-13(10-22)8-11-2-3-12(20)9-14(11)21/h2-7,9,13H,8,10,22H2,1H3,(H,25,27)(H,23,24,26)/t13-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 400n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of ERK1


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50364378
PNG
(CHEMBL1950289)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1ncc2nc(Nc3c(F)cc(F)cc3F)n([C@H]3CCOC3)c2n1
Show InChI InChI=1S/C21H23F3N6O2/c22-11-7-15(23)18(16(24)8-11)28-21-27-17-9-25-20(26-12-1-3-14(31)4-2-12)29-19(17)30(21)13-5-6-32-10-13/h7-9,12-14,31H,1-6,10H2,(H,27,28)(H,25,26,29)/t12-,13-,14-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 480n/an/an/an/an/an/a



Celgene Corporation

Curated by ChEMBL


Assay Description
Inhibition of ERK1


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50164704
PNG
(CHEMBL364935 | N*4*-(3H-Benzoimidazol-5-yl)-N*2*-(...)
Show SMILES FC(F)(F)c1cnc(Nc2ccc(Br)cc2)nc1Nc1ccc2nc[nH]c2c1
Show InChI InChI=1S/C18H12BrF3N6/c19-10-1-3-11(4-2-10)27-17-23-8-13(18(20,21)22)16(28-17)26-12-5-6-14-15(7-12)25-9-24-14/h1-9H,(H,24,25)(H2,23,26,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 750n/an/an/an/an/an/a



Bayer Research Center

Curated by ChEMBL


Assay Description
Inhibitory concentration against Extracellular signal-regulated kinase 1


Citation and Details
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 249 total )  |  Next  |  Last  >>
Jump to: