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Found 722 hits Enz. Inhib. hit(s) with Target = 'MAP kinase signal-integrating kinase 2'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181544
PNG
(US9139577, 4.050)
Show SMILES CCC(C)NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCCC1
Show InChI InChI=1/C26H32FN5O3S/c1-5-17(3)30-26(33)18(4)35-23-13-19(27)8-9-21(23)31-25-24-16(2)12-20(14-22(24)28-15-29-25)32-36(34)10-6-7-11-36/h8-9,12-15,17-18H,5-7,10-11H2,1-4H3,(H,30,33)(H,28,29,31)/t17?,18-/s2
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n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181536
PNG
(US9139577, 4.042)
Show SMILES CC(C)NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCCC1
Show InChI InChI=1/C25H30FN5O3S/c1-15(2)29-25(32)17(4)34-22-12-18(26)7-8-20(22)30-24-23-16(3)11-19(13-21(23)27-14-28-24)31-35(33)9-5-6-10-35/h7-8,11-15,17H,5-6,9-10H2,1-4H3,(H,29,32)(H,27,28,30)/t17-/s2
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n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181568
PNG
(US9139577, 4.074)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCCC1)C(=O)NCC(F)(F)F
Show InChI InChI=1/C24H25F4N5O3S/c1-14-9-17(33-37(35)7-3-4-8-37)11-19-21(14)22(31-13-30-19)32-18-6-5-16(25)10-20(18)36-15(2)23(34)29-12-24(26,27)28/h5-6,9-11,13,15H,3-4,7-8,12H2,1-2H3,(H,29,34)(H,30,31,32)/t15-/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181573
PNG
(US9139577, 4.079)
Show SMILES C[C@@H](Oc1cc(Cl)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCC1)C(=O)N[C@@H](C)C(F)(F)F
Show InChI InChI=1/C24H25ClF3N5O3S/c1-13-9-17(33-37(35)7-4-8-37)11-19-21(13)22(30-12-29-19)32-18-6-5-16(25)10-20(18)36-14(2)23(34)31-15(3)24(26,27)28/h5-6,9-12,14-15H,4,7-8H2,1-3H3,(H,31,34)(H,29,30,32)/t14-,15+/s2
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n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181583
PNG
(US9139577, 4.089 | US9139577, 4.108)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCC1)C(=O)NCCC(F)(F)F
Show InChI InChI=1/C24H25F4N5O3S/c1-14-10-17(33-37(35)8-3-9-37)12-19-21(14)22(31-13-30-19)32-18-5-4-16(25)11-20(18)36-15(2)23(34)29-7-6-24(26,27)28/h4-5,10-13,15H,3,6-9H2,1-2H3,(H,29,34)(H,30,31,32)/t15-/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181584
PNG
(US9139577, 4.090)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(Cl)c12)N=S1(=O)CCC1)C(=O)N[C@H](C)C(F)(F)F
Show InChI InChI=1/C23H22ClF4N5O3S/c1-12(22(34)31-13(2)23(26,27)28)36-19-8-14(25)4-5-17(19)32-21-20-16(24)9-15(10-18(20)29-11-30-21)33-37(35)6-3-7-37/h4-5,8-13H,3,6-7H2,1-2H3,(H,31,34)(H,29,30,32)/t12-,13-/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181585
PNG
(US9139577, 4.091)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(Cl)c12)N=S(C)(C)=O)C(=O)NCC(F)(F)F
Show InChI InChI=1/C21H20ClF4N5O3S/c1-11(20(32)27-9-21(24,25)26)34-17-6-12(23)4-5-15(17)30-19-18-14(22)7-13(31-35(2,3)33)8-16(18)28-10-29-19/h4-8,10-11H,9H2,1-3H3,(H,27,32)(H,28,29,30)/t11-/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181587
PNG
(US9139577, 4.093)
Show SMILES C[C@H](NC(=O)[C@@H](C)Oc1cc(Cl)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCCC1)C#N
Show InChI InChI=1/C24H24ClFN6O3S/c1-14(12-27)30-24(33)15(2)35-21-9-16(25)5-6-19(21)31-23-22-18(26)10-17(11-20(22)28-13-29-23)32-36(34)7-3-4-8-36/h5-6,9-11,13-15H,3-4,7-8H2,1-2H3,(H,30,33)(H,28,29,31)/t14-,15+/s2
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n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181588
PNG
(US9139577, 4.094)
Show SMILES C[C@@H](Oc1nc(Cl)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCC1)C(=O)N[C@@H](C)C(F)(F)F
Show InChI InChI=1/C23H24ClF3N6O3S/c1-12-9-15(33-37(35)7-4-8-37)10-17-19(12)20(29-11-28-17)31-16-5-6-18(24)32-22(16)36-13(2)21(34)30-14(3)23(25,26)27/h5-6,9-11,13-14H,4,7-8H2,1-3H3,(H,30,34)(H,28,29,31)/t13-,14+/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181590
PNG
(US9139577, 4.096)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(Cl)c12)N=S1(=O)CCC1)C(=O)N[C@@H](C)C(F)(F)F
Show InChI InChI=1/C23H22ClF4N5O3S/c1-12(22(34)31-13(2)23(26,27)28)36-19-8-14(25)4-5-17(19)32-21-20-16(24)9-15(10-18(20)29-11-30-21)33-37(35)6-3-7-37/h4-5,8-13H,3,6-7H2,1-2H3,(H,31,34)(H,29,30,32)/t12-,13+/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181591
PNG
(US9139577, 4.097)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1)C(=O)NCC#N
Show InChI InChI=1/C22H20F2N6O3S/c1-13(22(31)26-6-5-25)33-19-9-14(23)3-4-17(19)29-21-20-16(24)10-15(11-18(20)27-12-28-21)30-34(32)7-2-8-34/h3-4,9-13H,2,6-8H2,1H3,(H,26,31)(H,27,28,29)/t13-/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181597
PNG
(US9139577, 4.103)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCC1)C(=O)NCC#N
Show InChI InChI=1/C23H23FN6O3S/c1-14-10-17(30-34(32)8-3-9-34)12-19-21(14)22(28-13-27-19)29-18-5-4-16(24)11-20(18)33-15(2)23(31)26-7-6-25/h4-5,10-13,15H,3,7-9H2,1-2H3,(H,26,31)(H,27,28,29)/t15-/s2
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n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181598
PNG
(US9139577, 4.104)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCC1)C(=O)N[C@@H](C)C(F)(F)F
Show InChI InChI=1/C24H25F4N5O3S/c1-13-9-17(33-37(35)7-4-8-37)11-19-21(13)22(30-12-29-19)32-18-6-5-16(25)10-20(18)36-14(2)23(34)31-15(3)24(26,27)28/h5-6,9-12,14-15H,4,7-8H2,1-3H3,(H,31,34)(H,29,30,32)/t14-,15+/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181605
PNG
(US9139577, 4.111)
Show SMILES C[C@@H](Oc1cc(Cl)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCC1)C(=O)NCC(F)F
Show InChI InChI=1/C23H24ClF2N5O3S/c1-13-8-16(31-35(33)6-3-7-35)10-18-21(13)22(29-12-28-18)30-17-5-4-15(24)9-19(17)34-14(2)23(32)27-11-20(25)26/h4-5,8-10,12,14,20H,3,6-7,11H2,1-2H3,(H,27,32)(H,28,29,30)/t14-/s2
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n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181607
PNG
(US9139577, 4.113)
Show SMILES C[C@@H](NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1)C#N
Show InChI InChI=1/C23H22F2N6O3S/c1-13(11-26)29-23(32)14(2)34-20-8-15(24)4-5-18(20)30-22-21-17(25)9-16(10-19(21)27-12-28-22)31-35(33)6-3-7-35/h4-5,8-10,12-14H,3,6-7H2,1-2H3,(H,29,32)(H,27,28,30)/t13-,14-/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181616
PNG
(US9139577, 4.122)
Show SMILES C[C@@H](Oc1cc(Cl)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCC1)C(=O)NCC(F)(F)F
Show InChI InChI=1/C23H23ClF3N5O3S/c1-13-8-16(32-36(34)6-3-7-36)10-18-20(13)21(30-12-29-18)31-17-5-4-15(24)9-19(17)35-14(2)22(33)28-11-23(25,26)27/h4-5,8-10,12,14H,3,6-7,11H2,1-2H3,(H,28,33)(H,29,30,31)/t14-/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181618
PNG
(US9139577, 4.124)
Show SMILES C[C@@H](Oc1nc(Cl)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCC1)C(=O)NCC(F)(F)F
Show InChI InChI=1/C22H22ClF3N6O3S/c1-12-8-14(32-36(34)6-3-7-36)9-16-18(12)19(29-11-28-16)30-15-4-5-17(23)31-21(15)35-13(2)20(33)27-10-22(24,25)26/h4-5,8-9,11,13H,3,6-7,10H2,1-2H3,(H,27,33)(H,28,29,30)/t13-/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181619
PNG
(US9139577, 4.125)
Show SMILES CC(NC(=O)[C@@H](C)Oc1cc(Cl)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCC1)C(F)F
Show InChI InChI=1/C24H26ClF2N5O3S/c1-13-9-17(32-36(34)7-4-8-36)11-19-21(13)23(29-12-28-19)31-18-6-5-16(25)10-20(18)35-15(3)24(33)30-14(2)22(26)27/h5-6,9-12,14-15,22H,4,7-8H2,1-3H3,(H,30,33)(H,28,29,31)/t14?,15-/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181625
PNG
(US9139577, 4.131)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCC1)C(=O)NC(CF)CF
Show InChI InChI=1/C24H26F3N5O3S/c1-14-8-17(32-36(34)6-3-7-36)10-20-22(14)23(29-13-28-20)31-19-5-4-16(27)9-21(19)35-15(2)24(33)30-18(11-25)12-26/h4-5,8-10,13,15,18H,3,6-7,11-12H2,1-2H3,(H,30,33)(H,28,29,31)/t15-/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181626
PNG
(US9139577, 4.132)
Show SMILES CC(NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCC1)C#N
Show InChI InChI=1/C24H25FN6O3S/c1-14-9-18(31-35(33)7-4-8-35)11-20-22(14)23(28-13-27-20)30-19-6-5-17(25)10-21(19)34-16(3)24(32)29-15(2)12-26/h5-6,9-11,13,15-16H,4,7-8H2,1-3H3,(H,29,32)(H,27,28,30)/t15?,16-/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181630
PNG
(US9139577, 4.136)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1)C(=O)N[C@@H](C)C(F)(F)F
Show InChI InChI=1/C23H22F5N5O3S/c1-12(22(34)31-13(2)23(26,27)28)36-19-8-14(24)4-5-17(19)32-21-20-16(25)9-15(10-18(20)29-11-30-21)33-37(35)6-3-7-37/h4-5,8-13H,3,6-7H2,1-2H3,(H,31,34)(H,29,30,32)/t12-,13+/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181631
PNG
(US9139577, 4.137)
Show SMILES C[C@H](NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(cc(Cl)c12)N=S1(=O)CCC1)C#N
Show InChI InChI=1/C23H22ClFN6O3S/c1-13(11-26)29-23(32)14(2)34-20-8-15(25)4-5-18(20)30-22-21-17(24)9-16(10-19(21)27-12-28-22)31-35(33)6-3-7-35/h4-5,8-10,12-14H,3,6-7H2,1-2H3,(H,29,32)(H,27,28,30)/t13-,14+/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181632
PNG
(US9139577, 4.138)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(Cl)c12)N=S1(=O)CCC1)C(=O)NCC(F)(F)F
Show InChI InChI=1/C22H20ClF4N5O3S/c1-12(21(33)28-10-22(25,26)27)35-18-7-13(24)3-4-16(18)31-20-19-15(23)8-14(9-17(19)29-11-30-20)32-36(34)5-2-6-36/h3-4,7-9,11-12H,2,5-6,10H2,1H3,(H,28,33)(H,29,30,31)/t12-/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181633
PNG
(US9139577, 4.139)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCC1)C(=O)NCC(F)(F)F
Show InChI InChI=1/C23H23F4N5O3S/c1-13-8-16(32-36(34)6-3-7-36)10-18-20(13)21(30-12-29-18)31-17-5-4-15(24)9-19(17)35-14(2)22(33)28-11-23(25,26)27/h4-5,8-10,12,14H,3,6-7,11H2,1-2H3,(H,28,33)(H,29,30,31)/t14-/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181634
PNG
(US9139577, 4.140)
Show SMILES C[C@H](NC(=O)[C@@H](C)Oc1nc(Cl)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCC1)C#N
Show InChI InChI=1/C23H24ClN7O3S/c1-13-9-16(31-35(33)7-4-8-35)10-18-20(13)21(27-12-26-18)29-17-5-6-19(24)30-23(17)34-15(3)22(32)28-14(2)11-25/h5-6,9-10,12,14-15H,4,7-8H2,1-3H3,(H,28,32)(H,26,27,29)/t14-,15+/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181635
PNG
(US9139577, 4.141)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCC1)C(=O)NCC(F)F
Show InChI InChI=1/C23H24F3N5O3S/c1-13-8-16(31-35(33)6-3-7-35)10-18-21(13)22(29-12-28-18)30-17-5-4-15(24)9-19(17)34-14(2)23(32)27-11-20(25)26/h4-5,8-10,12,14,20H,3,6-7,11H2,1-2H3,(H,27,32)(H,28,29,30)/t14-/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181642
PNG
(US9139577, 5.001)
Show SMILES C[C@@H](CNS(C)(=O)=O)Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S(C)(C)=O
Show InChI InChI=1/C21H26FN5O4S2/c1-13-8-16(27-32(3,4)28)10-18-20(13)21(24-12-23-18)26-17-7-6-15(22)9-19(17)31-14(2)11-25-33(5,29)30/h6-10,12,14,25H,11H2,1-5H3,(H,23,24,26)/t14-/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181665
PNG
(US9139577, 7.001)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCN(C)CC1)c1cc(C)no1
Show InChI InChI=1/C26H29FN6O3S/c1-16-11-20(32-37(34)9-7-33(4)8-10-37)14-22-25(16)26(29-15-28-22)30-21-6-5-19(27)13-24(21)35-18(3)23-12-17(2)31-36-23/h5-6,11-15,18H,7-10H2,1-4H3,(H,28,29,30)/t18-/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181372
PNG
(US9139577, 1.003)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(Cl)c12)N=S(C)(C)=O)C(F)(F)F
Show InChI InChI=1/C19H17ClF4N4O2S/c1-10(19(22,23)24)30-16-6-11(21)4-5-14(16)27-18-17-13(20)7-12(28-31(2,3)29)8-15(17)25-9-26-18/h4-10H,1-3H3,(H,25,26,27)/t10-/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181385
PNG
(US9139577, 1.016)
Show SMILES C[C@@H](Oc1ncccc1Nc1ncnc2cc(cc(Cl)c12)N=S(C)(C)=O)c1cc(C)no1
Show InChI InChI=1/C21H21ClN6O3S/c1-12-8-18(31-27-12)13(2)30-21-16(6-5-7-23-21)26-20-19-15(22)9-14(28-32(3,4)29)10-17(19)24-11-25-20/h5-11,13H,1-4H3,(H,24,25,26)/t13-/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181388
PNG
(US9139577, 1.019)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(Cl)c12)N=S(C)(C)=O)c1cc(C)no1
Show InChI InChI=1/C22H21ClFN5O3S/c1-12-7-19(32-28-12)13(2)31-20-8-14(24)5-6-17(20)27-22-21-16(23)9-15(29-33(3,4)30)10-18(21)25-11-26-22/h5-11,13H,1-4H3,(H,25,26,27)/t13-/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181390
PNG
(US9139577, 1.021)
Show SMILES FCC(CF)Oc1cc(F)ccc1Nc1ncnc2cc(cc(c12)C(F)(F)F)N=S1(=O)CCOCC1
Show InChI InChI=1S/C22H20F6N4O3S/c23-10-15(11-24)35-19-7-13(25)1-2-17(19)31-21-20-16(22(26,27)28)8-14(9-18(20)29-12-30-21)32-36(33)5-3-34-4-6-36/h1-2,7-9,12,15H,3-6,10-11H2,(H,29,30,31)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181397
PNG
(US9139577, 2.005)
Show SMILES Cc1cc(cc2ncnc(Nc3cccnc3OCC3CCOC3)c12)N=S1(=O)CCCC1
Show InChI InChI=1/C23H27N5O3S/c1-16-11-18(28-32(29)9-2-3-10-32)12-20-21(16)22(26-15-25-20)27-19-5-4-7-24-23(19)31-14-17-6-8-30-13-17/h4-5,7,11-12,15,17H,2-3,6,8-10,13-14H2,1H3,(H,25,26,27)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181400
PNG
(US9139577, 2.008)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S(C)(C)=O)c1cc(C)no1
Show InChI InChI=1/C23H24FN5O3S/c1-13-8-17(29-33(4,5)30)11-19-22(13)23(26-12-25-19)27-18-7-6-16(24)10-21(18)31-15(3)20-9-14(2)28-32-20/h6-12,15H,1-5H3,(H,25,26,27)/t15-/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181401
PNG
(US9139577, 2.009)
Show SMILES C[C@@H](Oc1ncccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCCC1)c1cc(C)no1
Show InChI InChI=1/C24H26N6O3S/c1-15-11-18(30-34(31)9-4-5-10-34)13-20-22(15)23(27-14-26-20)28-19-7-6-8-25-24(19)32-17(3)21-12-16(2)29-33-21/h6-8,11-14,17H,4-5,9-10H2,1-3H3,(H,26,27,28)/t17-/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181408
PNG
(US9139577, 2.016)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCNCC1)c1cc(C)no1
Show InChI InChI=1/C25H27FN6O3S/c1-15-10-19(32-36(33)8-6-27-7-9-36)13-21-24(15)25(29-14-28-21)30-20-5-4-18(26)12-23(20)34-17(3)22-11-16(2)31-35-22/h4-5,10-14,17,27H,6-9H2,1-3H3,(H,28,29,30)/t17-/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181410
PNG
(US9139577, 2.018)
Show SMILES C[C@@H](Oc1ncccc1Nc1ncnc2cc(cc(C)c12)N=S(C)(C)=O)c1cc(C)no1
Show InChI InChI=1/C22H24N6O3S/c1-13-9-16(28-32(4,5)29)11-18-20(13)21(25-12-24-18)26-17-7-6-8-23-22(17)30-15(3)19-10-14(2)27-31-19/h6-12,15H,1-5H3,(H,24,25,26)/t15-/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181411
PNG
(US9139577, 2.019)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CC[C@H](N)C1)C(=O)NCC(F)(F)F
Show InChI InChI=1/C24H26F4N6O3S/c1-13-7-17(34-38(36)6-5-16(29)10-38)9-19-21(13)22(32-12-31-19)33-18-4-3-15(25)8-20(18)37-14(2)23(35)30-11-24(26,27)28/h3-4,7-9,12,14,16H,5-6,10-11,29H2,1-2H3,(H,30,35)(H,31,32,33)/t14-,16+,38?/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181418
PNG
(US9139577, 2.026)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CC(C)(C)C1)C(=O)NCC#N
Show InChI InChI=1/C24H24F2N6O3S/c1-14(23(33)28-7-6-27)35-20-8-15(25)4-5-18(20)31-22-21-17(26)9-16(10-19(21)29-13-30-22)32-36(34)11-24(2,3)12-36/h4-5,8-10,13-14H,7,11-12H2,1-3H3,(H,28,33)(H,29,30,31)/t14-/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181423
PNG
(US9139577, 2.032)
Show SMILES COC(=O)N1CC2(C1)CS(=O)(C2)=Nc1cc(C)c2c(Nc3ccc(F)cc3O[C@H](C)C(=O)NCC(F)(F)F)ncnc2c1
Show InChI InChI=1/C27H28F4N6O5S/c1-15-6-18(36-43(40)12-26(13-43)10-37(11-26)25(39)41-3)8-20-22(15)23(34-14-33-20)35-19-5-4-17(28)7-21(19)42-16(2)24(38)32-9-27(29,30)31/h4-8,14,16H,9-13H2,1-3H3,(H,32,38)(H,33,34,35)/t16-/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181425
PNG
(US9139577, 2.034)
Show SMILES C[C@@H](Oc1cc(Cl)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CC(C)(C)C1)C(=O)N[C@@H](C)C(F)(F)F
Show InChI InChI=1/C26H29ClF3N5O3S/c1-14-8-18(35-39(37)11-25(4,5)12-39)10-20-22(14)23(32-13-31-20)34-19-7-6-17(27)9-21(19)38-15(2)24(36)33-16(3)26(28,29)30/h6-10,13,15-16H,11-12H2,1-5H3,(H,33,36)(H,31,32,34)/t15-,16+/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181432
PNG
(US9139577, 2.041)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCC1)C(=O)NC(C(F)(F)F)C(F)(F)F
Show InChI InChI=1/C24H22F7N5O3S/c1-12-8-15(36-40(38)6-3-7-40)10-17-19(12)20(33-11-32-17)34-16-5-4-14(25)9-18(16)39-13(2)21(37)35-22(23(26,27)28)24(29,30)31/h4-5,8-11,13,22H,3,6-7H2,1-2H3,(H,35,37)(H,32,33,34)/t13-/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181435
PNG
(US9139577, 2.044)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CC(C)(C)C1)C(=O)NCC(F)(F)F
Show InChI InChI=1/C25H27F4N5O3S/c1-14-7-17(34-38(36)11-24(3,4)12-38)9-19-21(14)22(32-13-31-19)33-18-6-5-16(26)8-20(18)37-15(2)23(35)30-10-25(27,28)29/h5-9,13,15H,10-12H2,1-4H3,(H,30,35)(H,31,32,33)/t15-/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181436
PNG
(US9139577, 2.045)
Show SMILES C[C@@H](Oc1cc(Cl)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CC2(COC2)C1)C(=O)N[C@@H](C)C(F)(F)F
Show InChI InChI=1/C26H27ClF3N5O4S/c1-14-6-18(35-40(37)11-25(12-40)9-38-10-25)8-20-22(14)23(32-13-31-20)34-19-5-4-17(27)7-21(19)39-15(2)24(36)33-16(3)26(28,29)30/h4-8,13,15-16H,9-12H2,1-3H3,(H,33,36)(H,31,32,34)/t15-,16+/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181444
PNG
(US9139577, 3.005)
Show SMILES Cc1cc(cc2ncnc(Nc3ccc(F)cc3OCC#N)c12)N=S(C)(C)=O
Show InChI InChI=1S/C19H18FN5O2S/c1-12-8-14(25-28(2,3)26)10-16-18(12)19(23-11-22-16)24-15-5-4-13(20)9-17(15)27-7-6-21/h4-5,8-11H,7H2,1-3H3,(H,22,23,24)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181445
PNG
(US9139577, 3.006)
Show SMILES Cc1cc(cc2ncnc(Nc3ccc(F)cc3OCC3CCCCO3)c12)N=S(C)(C)=O
Show InChI InChI=1/C23H27FN4O3S/c1-15-10-17(28-32(2,3)29)12-20-22(15)23(26-14-25-20)27-19-8-7-16(24)11-21(19)31-13-18-6-4-5-9-30-18/h7-8,10-12,14,18H,4-6,9,13H2,1-3H3,(H,25,26,27)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181457
PNG
(US9139577, 3.018)
Show SMILES C[C@H](CN)Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S(C)(C)=O
Show InChI InChI=1/C20H24FN5O2S/c1-12-7-15(26-29(3,4)27)9-17-19(12)20(24-11-23-17)25-16-6-5-14(21)8-18(16)28-13(2)10-22/h5-9,11,13H,10,22H2,1-4H3,(H,23,24,25)/t13-/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181478
PNG
(US9139577, 3.039)
Show SMILES Cc1cc(cc2ncnc(Nc3ccc(F)cc3OCc3ccon3)c12)N=S(C)(C)=O
Show InChI InChI=1S/C21H20FN5O3S/c1-13-8-16(27-31(2,3)28)10-18-20(13)21(24-12-23-18)25-17-5-4-14(22)9-19(17)29-11-15-6-7-30-26-15/h4-10,12H,11H2,1-3H3,(H,23,24,25)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181486
PNG
(US9139577, 3.047)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCCC1)C(=O)NCC(F)(F)F
Show InChI InChI=1/C23H22F5N5O3S/c1-13(22(34)29-11-23(26,27)28)36-19-8-14(24)4-5-17(19)32-21-20-16(25)9-15(10-18(20)30-12-31-21)33-37(35)6-2-3-7-37/h4-5,8-10,12-13H,2-3,6-7,11H2,1H3,(H,29,34)(H,30,31,32)/t13-/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181493
PNG
(US9139577, 3.054)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S(C)(C)=O)C(=O)NC(C(F)(F)F)C(F)(F)F
Show InChI InChI=1/C23H22F7N5O3S/c1-11-7-14(35-39(3,4)37)9-16-18(11)19(32-10-31-16)33-15-6-5-13(24)8-17(15)38-12(2)20(36)34-21(22(25,26)27)23(28,29)30/h5-10,12,21H,1-4H3,(H,34,36)(H,31,32,33)/t12-/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
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