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Compile Data Set for Download or QSAR

Found 191 hits Enz. Inhib. hit(s) with Target = 'MAP kinase-activated protein kinase 5'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM30185
PNG
(CHEMBL226403 | Pyrrolopyridine, 16)
Show SMILES O=C1NCCc2[nH]c(cc12)-c1ccnc(c1)-c1cnc2ccccc2c1
Show InChI InChI=1S/C21H16N4O/c26-21-16-11-20(25-18(16)6-8-23-21)14-5-7-22-19(10-14)15-9-13-3-1-2-4-17(13)24-12-15/h1-5,7,9-12,25H,6,8H2,(H,23,26)
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n/an/a 81n/an/an/an/a7.530



Pfizer



Assay Description
Compounds were evaluated as inhibitors of kinase by measuring their effect on kinase induced phosphorylation of substrate. IC50 values were reported ...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM50365798
PNG
(CHEMBL1956685)
Show SMILES NC(=O)c1cc(co1)-c1cnc(Nc2ccc(cc2)N2CCOCC2)c2nccn12
Show InChI InChI=1S/C21H20N6O3/c22-19(28)18-11-14(13-30-18)17-12-24-20(21-23-5-6-27(17)21)25-15-1-3-16(4-2-15)26-7-9-29-10-8-26/h1-6,11-13H,7-10H2,(H2,22,28)(H,24,25)
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n/an/a 88n/an/an/an/an/an/a



Galapagos NV

Curated by ChEMBL


Assay Description
Inhibition of MAPKAPK5


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM30185
PNG
(CHEMBL226403 | Pyrrolopyridine, 16)
Show SMILES O=C1NCCc2[nH]c(cc12)-c1ccnc(c1)-c1cnc2ccccc2c1
Show InChI InChI=1S/C21H16N4O/c26-21-16-11-20(25-18(16)6-8-23-21)14-5-7-22-19(10-14)15-9-13-3-1-2-4-17(13)24-12-15/h1-5,7,9-12,25H,6,8H2,(H,23,26)
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n/an/a 100n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of MAPKAPK5 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM30178
PNG
(Pyrrolopyridine, 9)
Show SMILES O=C1NCCc2[nH]c(cc12)-c1ccnc(c1)-c1ccccc1
Show InChI InChI=1S/C18H15N3O/c22-18-14-11-17(21-15(14)7-9-20-18)13-6-8-19-16(10-13)12-4-2-1-3-5-12/h1-6,8,10-11,21H,7,9H2,(H,20,22)
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n/an/a 140n/an/an/an/a7.530



Pfizer



Assay Description
Compounds were evaluated as inhibitors of kinase by measuring their effect on kinase induced phosphorylation of substrate. IC50 values were reported ...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM50365797
PNG
(CHEMBL1956684)
Show SMILES NC(=O)c1coc(c1)-c1cnc(Nc2ccc(cc2)N2CCOCC2)c2nccn12
Show InChI InChI=1S/C21H20N6O3/c22-19(28)14-11-18(30-13-14)17-12-24-20(21-23-5-6-27(17)21)25-15-1-3-16(4-2-15)26-7-9-29-10-8-26/h1-6,11-13H,7-10H2,(H2,22,28)(H,24,25)
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n/an/a 148n/an/an/an/an/an/a



Galapagos NV

Curated by ChEMBL


Assay Description
Inhibition of MAPKAPK5


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM50365801
PNG
(CHEMBL1956682)
Show SMILES O=C1NCc2cc(ccc12)-c1cnc(Nc2ccc(cc2)N2CCOCC2)c2ncnn12
Show InChI InChI=1S/C23H21N7O2/c31-23-19-6-1-15(11-16(19)12-25-23)20-13-24-21(22-26-14-27-30(20)22)28-17-2-4-18(5-3-17)29-7-9-32-10-8-29/h1-6,11,13-14H,7-10,12H2,(H,24,28)(H,25,31)
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n/an/a 195n/an/an/an/an/an/a



Galapagos NV

Curated by ChEMBL


Assay Description
Inhibition of MAPKAPK5


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM30192
PNG
(Pyrrolopyridine, 23)
Show SMILES Fc1ccccc1-c1cc(ccn1)-c1cc2c(CCNC2=O)[nH]1
Show InChI InChI=1S/C18H14FN3O/c19-14-4-2-1-3-12(14)17-9-11(5-7-20-17)16-10-13-15(22-16)6-8-21-18(13)23/h1-5,7,9-10,22H,6,8H2,(H,21,23)
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n/an/a 210n/an/an/an/a7.530



Pfizer



Assay Description
Compounds were evaluated as inhibitors of kinase by measuring their effect on kinase induced phosphorylation of substrate. IC50 values were reported ...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM50365797
PNG
(CHEMBL1956684)
Show SMILES NC(=O)c1coc(c1)-c1cnc(Nc2ccc(cc2)N2CCOCC2)c2nccn12
Show InChI InChI=1S/C21H20N6O3/c22-19(28)14-11-18(30-13-14)17-12-24-20(21-23-5-6-27(17)21)25-15-1-3-16(4-2-15)26-7-9-29-10-8-26/h1-6,11-13H,7-10H2,(H2,22,28)(H,24,25)
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n/an/a 227n/an/an/an/an/an/a



Galapagos NV

Curated by ChEMBL


Assay Description
Inhibition of MAPKAPK5 in syonovial fibroblast from rheumatoid arthritis patient assessed as inhibition of TNF-alpha-induced MMP1 expression incubate...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM50365795
PNG
(CHEMBL1956574)
Show SMILES O=C1NCc2cc(ccc12)-c1cnc(Nc2ccc(cc2)N2CCOCC2)c2nccn12
Show InChI InChI=1S/C24H22N6O2/c31-24-20-6-1-16(13-17(20)14-27-24)21-15-26-22(23-25-7-8-30(21)23)28-18-2-4-19(5-3-18)29-9-11-32-12-10-29/h1-8,13,15H,9-12,14H2,(H,26,28)(H,27,31)
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n/an/a 239n/an/an/an/an/an/a



Galapagos NV

Curated by ChEMBL


Assay Description
Inhibition of MAPKAPK5


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM50365799
PNG
(CHEMBL1956686)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(-c3cc[nH]c(=O)c3)n3ccnc23)cc1
Show InChI InChI=1S/C22H23N7O/c1-27-10-12-28(13-11-27)18-4-2-17(3-5-18)26-21-22-24-8-9-29(22)19(15-25-21)16-6-7-23-20(30)14-16/h2-9,14-15H,10-13H2,1H3,(H,23,30)(H,25,26)
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n/an/a 290n/an/an/an/an/an/a



Galapagos NV

Curated by ChEMBL


Assay Description
Inhibition of MAPKAPK5


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM50365794
PNG
(CHEMBL1956573)
Show SMILES NC(=O)c1cc(cs1)-c1cnc(Nc2ccc(cc2)N2CCOCC2)c2nccn12
Show InChI InChI=1S/C21H20N6O2S/c22-19(28)18-11-14(13-30-18)17-12-24-20(21-23-5-6-27(17)21)25-15-1-3-16(4-2-15)26-7-9-29-10-8-26/h1-6,11-13H,7-10H2,(H2,22,28)(H,24,25)
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n/an/a 327n/an/an/an/an/an/a



Galapagos NV

Curated by ChEMBL


Assay Description
Inhibition of MAPKAPK5 in syonovial fibroblast from rheumatoid arthritis patient assessed as inhibition of TNF-alpha-induced MMP1 expression incubate...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM50365788
PNG
(CHEMBL1956567)
Show SMILES O=c1cc(cc[nH]1)-c1cnc(Nc2ccc(cc2)N2CCOCC2)c2nccn12
Show InChI InChI=1S/C21H20N6O2/c28-19-13-15(5-6-22-19)18-14-24-20(21-23-7-8-27(18)21)25-16-1-3-17(4-2-16)26-9-11-29-12-10-26/h1-8,13-14H,9-12H2,(H,22,28)(H,24,25)
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n/an/a 390n/an/an/an/an/an/a



Galapagos NV

Curated by ChEMBL


Assay Description
Inhibition of MAPKAPK5


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM50365791
PNG
(CHEMBL1956570)
Show SMILES NC(=O)c1ccc(s1)-c1cnc(Nc2ccc(cc2)N2CCOCC2)c2nccn12
Show InChI InChI=1S/C21H20N6O2S/c22-19(28)18-6-5-17(30-18)16-13-24-20(21-23-7-8-27(16)21)25-14-1-3-15(4-2-14)26-9-11-29-12-10-26/h1-8,13H,9-12H2,(H2,22,28)(H,24,25)
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n/an/a 392n/an/an/an/an/an/a



Galapagos NV

Curated by ChEMBL


Assay Description
Inhibition of MAPKAPK5 in syonovial fibroblast from rheumatoid arthritis patient assessed as inhibition of TNF-alpha-induced MMP1 expression incubate...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM50365794
PNG
(CHEMBL1956573)
Show SMILES NC(=O)c1cc(cs1)-c1cnc(Nc2ccc(cc2)N2CCOCC2)c2nccn12
Show InChI InChI=1S/C21H20N6O2S/c22-19(28)18-11-14(13-30-18)17-12-24-20(21-23-5-6-27(17)21)25-15-1-3-16(4-2-15)26-7-9-29-10-8-26/h1-6,11-13H,7-10H2,(H2,22,28)(H,24,25)
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n/an/a 437n/an/an/an/an/an/a



Galapagos NV

Curated by ChEMBL


Assay Description
Inhibition of MAPKAPK5


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM50365801
PNG
(CHEMBL1956682)
Show SMILES O=C1NCc2cc(ccc12)-c1cnc(Nc2ccc(cc2)N2CCOCC2)c2ncnn12
Show InChI InChI=1S/C23H21N7O2/c31-23-19-6-1-15(11-16(19)12-25-23)20-13-24-21(22-26-14-27-30(20)22)28-17-2-4-18(5-3-17)29-7-9-32-10-8-29/h1-6,11,13-14H,7-10,12H2,(H,24,28)(H,25,31)
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n/an/a 445n/an/an/an/an/an/a



Galapagos NV

Curated by ChEMBL


Assay Description
Inhibition of MAPKAPK5 in syonovial fibroblast from rheumatoid arthritis patient assessed as inhibition of TNF-alpha-induced MMP1 expression incubate...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM27344
PNG
(2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3,2-c]pyri...)
Show SMILES O=C1NCCc2[nH]c(cc12)-c1ccncc1
Show InChI InChI=1S/C12H11N3O/c16-12-9-7-11(8-1-4-13-5-2-8)15-10(9)3-6-14-12/h1-2,4-5,7,15H,3,6H2,(H,14,16)
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n/an/a 500n/an/an/an/a7.530



Pfizer



Assay Description
Compounds were evaluated as inhibitors of kinase by measuring their effect on kinase induced phosphorylation of substrate. IC50 values were reported ...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM50413752
PNG
(CHEMBL2012519 | L-783277)
Show SMILES COc1cc(O)c2c(CCCC(=O)C(=O)C(O)CCC[C@H](C)OC2=O)c1
Show InChI InChI=1S/C19H24O7/c1-11-5-3-7-14(20)18(23)15(21)8-4-6-12-9-13(25-2)10-16(22)17(12)19(24)26-11/h9-11,14,20,22H,3-8H2,1-2H3/t11-,14?/m0/s1
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n/an/a 640n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of MK5 by TR-FRET based LanthaScreen assay


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM50365795
PNG
(CHEMBL1956574)
Show SMILES O=C1NCc2cc(ccc12)-c1cnc(Nc2ccc(cc2)N2CCOCC2)c2nccn12
Show InChI InChI=1S/C24H22N6O2/c31-24-20-6-1-16(13-17(20)14-27-24)21-15-26-22(23-25-7-8-30(21)23)28-18-2-4-19(5-3-18)29-9-11-32-12-10-29/h1-8,13,15H,9-12,14H2,(H,26,28)(H,27,31)
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n/an/a 676n/an/an/an/an/an/a



Galapagos NV

Curated by ChEMBL


Assay Description
Inhibition of MAPKAPK5 in syonovial fibroblast from rheumatoid arthritis patient assessed as inhibition of TNF-alpha-induced MMP1 expression incubate...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM50365798
PNG
(CHEMBL1956685)
Show SMILES NC(=O)c1cc(co1)-c1cnc(Nc2ccc(cc2)N2CCOCC2)c2nccn12
Show InChI InChI=1S/C21H20N6O3/c22-19(28)18-11-14(13-30-18)17-12-24-20(21-23-5-6-27(17)21)25-15-1-3-16(4-2-15)26-7-9-29-10-8-26/h1-6,11-13H,7-10H2,(H2,22,28)(H,24,25)
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n/an/a 702n/an/an/an/an/an/a



Galapagos NV

Curated by ChEMBL


Assay Description
Inhibition of MAPKAPK5 in syonovial fibroblast from rheumatoid arthritis patient assessed as inhibition of TNF-alpha-induced MMP1 expression incubate...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM50365800
PNG
(CHEMBL1956687)
Show SMILES C1CN(CCO1)c1ccc(Nc2ncc(-c3cn[nH]c3)n3ncnc23)cc1
Show InChI InChI=1S/C18H18N8O/c1-3-15(25-5-7-27-8-6-25)4-2-14(1)24-17-18-20-12-23-26(18)16(11-19-17)13-9-21-22-10-13/h1-4,9-12H,5-8H2,(H,19,24)(H,21,22)
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n/an/a 816n/an/an/an/an/an/a



Galapagos NV

Curated by ChEMBL


Assay Description
Inhibition of MAPKAPK5


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM50365782
PNG
(CHEMBL1956561)
Show SMILES C1CN(CCO1)c1ccc(Nc2ncc(-c3cn[nH]c3)n3ccnc23)cc1
Show InChI InChI=1S/C19H19N7O/c1-3-16(25-7-9-27-10-8-25)4-2-15(1)24-18-19-20-5-6-26(19)17(13-21-18)14-11-22-23-12-14/h1-6,11-13H,7-10H2,(H,21,24)(H,22,23)
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n/an/a 829n/an/an/an/an/an/a



Galapagos NV

Curated by ChEMBL


Assay Description
Inhibition of MAPKAPK5


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM50365788
PNG
(CHEMBL1956567)
Show SMILES O=c1cc(cc[nH]1)-c1cnc(Nc2ccc(cc2)N2CCOCC2)c2nccn12
Show InChI InChI=1S/C21H20N6O2/c28-19-13-15(5-6-22-19)18-14-24-20(21-23-7-8-27(18)21)25-16-1-3-17(4-2-16)26-9-11-29-12-10-26/h1-8,13-14H,9-12H2,(H,22,28)(H,24,25)
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n/an/a 871n/an/an/an/an/an/a



Galapagos NV

Curated by ChEMBL


Assay Description
Inhibition of MAPKAPK5 in syonovial fibroblast from rheumatoid arthritis patient assessed as inhibition of TNF-alpha-induced MMP1 expression incubate...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM50365799
PNG
(CHEMBL1956686)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(-c3cc[nH]c(=O)c3)n3ccnc23)cc1
Show InChI InChI=1S/C22H23N7O/c1-27-10-12-28(13-11-27)18-4-2-17(3-5-18)26-21-22-24-8-9-29(22)19(15-25-21)16-6-7-23-20(30)14-16/h2-9,14-15H,10-13H2,1H3,(H,23,30)(H,25,26)
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n/an/a 871n/an/an/an/an/an/a



Galapagos NV

Curated by ChEMBL


Assay Description
Inhibition of MAPKAPK5 in syonovial fibroblast from rheumatoid arthritis patient assessed as inhibition of TNF-alpha-induced MMP1 expression incubate...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM50365785
PNG
(CHEMBL1956564)
Show SMILES NC(=O)c1ccc(cc1)-c1cnc(Nc2ccc(cc2)N2CCOCC2)c2nccn12
Show InChI InChI=1S/C23H22N6O2/c24-21(30)17-3-1-16(2-4-17)20-15-26-22(23-25-9-10-29(20)23)27-18-5-7-19(8-6-18)28-11-13-31-14-12-28/h1-10,15H,11-14H2,(H2,24,30)(H,26,27)
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n/an/a 914n/an/an/an/an/an/a



Galapagos NV

Curated by ChEMBL


Assay Description
Inhibition of MAPKAPK5 in syonovial fibroblast from rheumatoid arthritis patient assessed as inhibition of TNF-alpha-induced MMP1 expression incubate...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM50126732
PNG
(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Show SMILES CCN(CC)CC=Cc1[nH]c(=O)c2c3n(C)c(Nc4c(Cl)cccc4Cl)nc3ccc2c1C
Show InChI InChI=1S/C25H27Cl2N5O/c1-5-32(6-2)14-8-11-19-15(3)16-12-13-20-23(21(16)24(33)28-19)31(4)25(29-20)30-22-17(26)9-7-10-18(22)27/h7-13H,5-6,14H2,1-4H3,(H,28,33)(H,29,30)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of Protein kinase PRAK


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM50192071
PNG
((13R,15S)-13-methyl-16-oxa-8,9,12,22,24-pentaazahe...)
Show SMILES C[C@@H]1C[C@H]2CN1CCn1[nH]c3c(cccc3c1=O)-c1nc3c(O2)cccc3[nH]c1=O
Show InChI InChI=1S/C22H21N5O3/c1-12-10-13-11-26(12)8-9-27-22(29)15-5-2-4-14(18(15)25-27)19-21(28)23-16-6-3-7-17(30-13)20(16)24-19/h2-7,12-13,25H,8-11H2,1H3,(H,23,28)/t12-,13+/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of PRAK


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM50365785
PNG
(CHEMBL1956564)
Show SMILES NC(=O)c1ccc(cc1)-c1cnc(Nc2ccc(cc2)N2CCOCC2)c2nccn12
Show InChI InChI=1S/C23H22N6O2/c24-21(30)17-3-1-16(2-4-17)20-15-26-22(23-25-9-10-29(20)23)27-18-5-7-19(8-6-18)28-11-13-31-14-12-28/h1-10,15H,11-14H2,(H2,24,30)(H,26,27)
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n/an/a 1.37E+3n/an/an/an/an/an/a



Galapagos NV

Curated by ChEMBL


Assay Description
Inhibition of MAPKAPK5


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM50365791
PNG
(CHEMBL1956570)
Show SMILES NC(=O)c1ccc(s1)-c1cnc(Nc2ccc(cc2)N2CCOCC2)c2nccn12
Show InChI InChI=1S/C21H20N6O2S/c22-19(28)18-6-5-17(30-18)16-13-24-20(21-23-7-8-27(16)21)25-14-1-3-15(4-2-14)26-9-11-29-12-10-26/h1-8,13H,9-12H2,(H2,22,28)(H,24,25)
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n/an/a 1.42E+3n/an/an/an/an/an/a



Galapagos NV

Curated by ChEMBL


Assay Description
Inhibition of MAPKAPK5


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM50365784
PNG
(CHEMBL1956563)
Show SMILES C1CN(CCO1)c1ccc(Nc2ncc(-c3c[nH]nn3)n3ccnc23)cc1
Show InChI InChI=1S/C18H18N8O/c1-3-14(25-7-9-27-10-8-25)4-2-13(1)22-17-18-19-5-6-26(18)16(12-20-17)15-11-21-24-23-15/h1-6,11-12H,7-10H2,(H,20,22)(H,21,23,24)
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n/an/a 1.49E+3n/an/an/an/an/an/a



Galapagos NV

Curated by ChEMBL


Assay Description
Inhibition of MAPKAPK5


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM50363167
PNG
(CHEMBL1945559)
Show SMILES Cn1c2c(C(C#N)C3(CCNCC3)NC2=O)c2ccc(Cl)c(Cl)c12
Show InChI InChI=1S/C17H16Cl2N4O/c1-23-14-9(2-3-11(18)13(14)19)12-10(8-20)17(4-6-21-7-5-17)22-16(24)15(12)23/h2-3,10,21H,4-7H2,1H3,(H,22,24)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Ludwig-Maximilians University of Munich

Curated by ChEMBL


Assay Description
Inhibition of MK5 using ATP as substrate


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM50126829
PNG
((E)-1-(6-(3-acetyl-2,4,6-trihydroxy-5-methylbenzyl...)
Show SMILES CC(=O)c1c(O)c(C)c(O)c(Cc2c(O)c3C=CC(C)(C)Oc3c(C(=O)C=Cc3ccccc3)c2O)c1O
Show InChI InChI=1S/C30H28O8/c1-15-24(33)19(27(36)22(16(2)31)25(15)34)14-20-26(35)18-12-13-30(3,4)38-29(18)23(28(20)37)21(32)11-10-17-8-6-5-7-9-17/h5-13,33-37H,14H2,1-4H3
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n/an/a 1.90E+3n/an/an/an/an/an/a



University of Dundee

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human PRAK expressed in Sf9 cells


Biochem J 351: 95-105 (2001)

More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM50126829
PNG
((E)-1-(6-(3-acetyl-2,4,6-trihydroxy-5-methylbenzyl...)
Show SMILES CC(=O)c1c(O)c(C)c(O)c(Cc2c(O)c3C=CC(C)(C)Oc3c(C(=O)C=Cc3ccccc3)c2O)c1O
Show InChI InChI=1S/C30H28O8/c1-15-24(33)19(27(36)22(16(2)31)25(15)34)14-20-26(35)18-12-13-30(3,4)38-29(18)23(28(20)37)21(32)11-10-17-8-6-5-7-9-17/h5-13,33-37H,14H2,1-4H3
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n/an/a 1.90E+3n/an/an/an/an/an/a



Northwestern University

Curated by ChEMBL


Assay Description
Inhibition of p38-regulated activated kinase (PRAK)


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM50365787
PNG
(CHEMBL1956566)
Show SMILES NC(=O)c1ccc(cc1F)-c1cnc(Nc2ccc(cc2)N2CCOCC2)c2nccn12
Show InChI InChI=1S/C23H21FN6O2/c24-19-13-15(1-6-18(19)21(25)31)20-14-27-22(23-26-7-8-30(20)23)28-16-2-4-17(5-3-16)29-9-11-32-12-10-29/h1-8,13-14H,9-12H2,(H2,25,31)(H,27,28)
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n/an/a 2.39E+3n/an/an/an/an/an/a



Galapagos NV

Curated by ChEMBL


Assay Description
Inhibition of MAPKAPK5


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM50365800
PNG
(CHEMBL1956687)
Show SMILES C1CN(CCO1)c1ccc(Nc2ncc(-c3cn[nH]c3)n3ncnc23)cc1
Show InChI InChI=1S/C18H18N8O/c1-3-15(25-5-7-27-8-6-25)4-2-14(1)24-17-18-20-12-23-26(18)16(11-19-17)13-9-21-22-10-13/h1-4,9-12H,5-8H2,(H,19,24)(H,21,22)
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n/an/a 2.61E+3n/an/an/an/an/an/a



Galapagos NV

Curated by ChEMBL


Assay Description
Inhibition of MAPKAPK5 in syonovial fibroblast from rheumatoid arthritis patient assessed as inhibition of TNF-alpha-induced MMP1 expression incubate...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM50365792
PNG
(CHEMBL1956571)
Show SMILES NC(=O)c1cnc(s1)-c1cnc(Nc2ccc(cc2)N2CCOCC2)c2nccn12
Show InChI InChI=1S/C20H19N7O2S/c21-17(28)16-12-24-20(30-16)15-11-23-18(19-22-5-6-27(15)19)25-13-1-3-14(4-2-13)26-7-9-29-10-8-26/h1-6,11-12H,7-10H2,(H2,21,28)(H,23,25)
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n/an/a 2.82E+3n/an/an/an/an/an/a



Galapagos NV

Curated by ChEMBL


Assay Description
Inhibition of MAPKAPK5


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM50365782
PNG
(CHEMBL1956561)
Show SMILES C1CN(CCO1)c1ccc(Nc2ncc(-c3cn[nH]c3)n3ccnc23)cc1
Show InChI InChI=1S/C19H19N7O/c1-3-16(25-7-9-27-10-8-25)4-2-15(1)24-18-19-20-5-6-26(19)17(13-21-18)14-11-22-23-12-14/h1-6,11-13H,7-10H2,(H,21,24)(H,22,23)
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n/an/a 2.82E+3n/an/an/an/an/an/a



Galapagos NV

Curated by ChEMBL


Assay Description
Inhibition of MAPKAPK5 in syonovial fibroblast from rheumatoid arthritis patient assessed as inhibition of TNF-alpha-induced MMP1 expression incubate...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM50365793
PNG
(CHEMBL1956572)
Show SMILES NC(=O)c1ncc(s1)-c1cnc(Nc2ccc(cc2)N2CCOCC2)c2nccn12
Show InChI InChI=1S/C20H19N7O2S/c21-17(28)20-24-12-16(30-20)15-11-23-18(19-22-5-6-27(15)19)25-13-1-3-14(4-2-13)26-7-9-29-10-8-26/h1-6,11-12H,7-10H2,(H2,21,28)(H,23,25)
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n/an/a 3.20E+3n/an/an/an/an/an/a



Galapagos NV

Curated by ChEMBL


Assay Description
Inhibition of MAPKAPK5


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM50365802
PNG
(CHEMBL1956683)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(-c3cc[nH]c(=O)c3)n3ncnc23)cc1
Show InChI InChI=1S/C21H22N8O/c1-27-8-10-28(11-9-27)17-4-2-16(3-5-17)26-20-21-24-14-25-29(21)18(13-23-20)15-6-7-22-19(30)12-15/h2-7,12-14H,8-11H2,1H3,(H,22,30)(H,23,26)
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n/an/a 3.73E+3n/an/an/an/an/an/a



Galapagos NV

Curated by ChEMBL


Assay Description
Inhibition of MAPKAPK5


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM175242
PNG
(US9115089, 49)
Show SMILES Cc1cnc(cc1-n1c(C)cc(OCc2ncc(F)cc2F)c(Cl)c1=O)-c1ccnc(n1)C(C)(C)O
Show InChI InChI=1S/C25H22ClF2N5O3/c1-13-10-30-18(17-5-6-29-24(32-17)25(3,4)35)9-20(13)33-14(2)7-21(22(26)23(33)34)36-12-19-16(28)8-15(27)11-31-19/h5-11,35H,12H2,1-4H3
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US Patent
n/an/a 8.10E+3n/an/an/an/an/an/a



CONFLUENCE LIFE SCIENCES, INC.

US Patent


Assay Description
The ability of compounds to inhibit activated phospho-p38alpha is evaluated using a p38alpha /MK2 and a p38alpha /PRAK cascade assay format. The kina...


US Patent US9115089 (2015)

More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM50169959
PNG
(2-(benzo[d]thiazol-2(3H)-ylidene)-2-(2-(2-(pyridin...)
Show SMILES N#CC(c1nc2ccccc2s1)c1ccnc(NCCc2cccnc2)n1
Show InChI InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,15H,7,10H2,(H,23,24,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Serono Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of protein kinase PRAK


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM50193995
PNG
(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Show SMILES C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N
Show InChI InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Global Researchand Development

Curated by ChEMBL


Assay Description
Inhibition of PRAK


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM50330261
PNG
(4-(5-Chloro-3-isopropyl-1H-pyrazol-4-yl)-N-(5-(4-(...)
Show SMILES CC(C)c1n[nH]c(Cl)c1-c1ccnc(Nc2ccc(cn2)N2CCC(CC2)N(C)C)n1
Show InChI InChI=1S/C22H29ClN8/c1-14(2)20-19(21(23)29-28-20)17-7-10-24-22(26-17)27-18-6-5-16(13-25-18)31-11-8-15(9-12-31)30(3)4/h5-7,10,13-15H,8-9,11-12H2,1-4H3,(H,28,29)(H,24,25,26,27)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of MAPK5


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM50330262
PNG
(CHEMBL1272171 | N*6'*-[4-(5-Isopropyl-3-trifluorom...)
Show SMILES CC(C)c1[nH]nc(c1-c1ccnc(Nc2ccc(cn2)N2CCC(CC2)N(C)C)n1)C(F)(F)F
Show InChI InChI=1S/C23H29F3N8/c1-14(2)20-19(21(32-31-20)23(24,25)26)17-7-10-27-22(29-17)30-18-6-5-16(13-28-18)34-11-8-15(9-12-34)33(3)4/h5-7,10,13-15H,8-9,11-12H2,1-4H3,(H,31,32)(H,27,28,29,30)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of MAPK5


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM50335376
PNG
((S)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,12-...)
Show SMILES COc1cc(O)c2c(CCCCCC(=O)C=CC[C@H](C)OC2=O)c1
Show InChI InChI=1S/C19H24O5/c1-13-7-6-10-15(20)9-5-3-4-8-14-11-16(23-2)12-17(21)18(14)19(22)24-13/h6,10-13,21H,3-5,7-9H2,1-2H3/t13-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of MK5 by TR-FRET based LanthaScreen assay


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM50355393
PNG
(CHEMBL1834657)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)cc1
Show InChI InChI=1S/C26H31Cl2N7O3/c1-5-34-10-12-35(13-11-34)18-8-6-17(7-9-18)31-21-15-22(30-16-29-21)33(2)26(36)32-25-23(27)19(37-3)14-20(38-4)24(25)28/h6-9,14-16H,5,10-13H2,1-4H3,(H,32,36)(H,29,30,31)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Novartis Institute for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant MK5


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM50365783
PNG
(CHEMBL1956562)
Show SMILES CN(c1ccc(cc1)N1CCOCC1)c1ncc(-c2cn[nH]c2)n2ccnc12
Show InChI InChI=1S/C20H21N7O/c1-25(16-2-4-17(5-3-16)26-8-10-28-11-9-26)19-20-21-6-7-27(20)18(14-22-19)15-12-23-24-13-15/h2-7,12-14H,8-11H2,1H3,(H,23,24)
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Galapagos NV

Curated by ChEMBL


Assay Description
Inhibition of MAPKAPK5


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM50365786
PNG
(CHEMBL1956565)
Show SMILES NS(=O)(=O)c1ccc(cc1)-c1cnc(Nc2ccc(cc2)N2CCOCC2)c2nccn12
Show InChI InChI=1S/C22H22N6O3S/c23-32(29,30)19-7-1-16(2-8-19)20-15-25-21(22-24-9-10-28(20)22)26-17-3-5-18(6-4-17)27-11-13-31-14-12-27/h1-10,15H,11-14H2,(H,25,26)(H2,23,29,30)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Galapagos NV

Curated by ChEMBL


Assay Description
Inhibition of MAPKAPK5


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM50365789
PNG
(CHEMBL1956568)
Show SMILES CCOc1cc(ccn1)-c1cnc(Nc2ccc(cc2)N2CCOCC2)c2nccn12
Show InChI InChI=1S/C23H24N6O2/c1-2-31-21-15-17(7-8-24-21)20-16-26-22(23-25-9-10-29(20)23)27-18-3-5-19(6-4-18)28-11-13-30-14-12-28/h3-10,15-16H,2,11-14H2,1H3,(H,26,27)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Galapagos NV

Curated by ChEMBL


Assay Description
Inhibition of MAPKAPK5


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM50365790
PNG
(CHEMBL1956569)
Show SMILES CN(C)c1cc(ccn1)-c1cnc(Nc2ccc(cc2)N2CCOCC2)c2nccn12
Show InChI InChI=1S/C23H25N7O/c1-28(2)21-15-17(7-8-24-21)20-16-26-22(23-25-9-10-30(20)23)27-18-3-5-19(6-4-18)29-11-13-31-14-12-29/h3-10,15-16H,11-14H2,1-2H3,(H,26,27)
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Galapagos NV

Curated by ChEMBL


Assay Description
Inhibition of MAPKAPK5


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 5


(Homo sapiens (human))
BDBM50365796
PNG
(CHEMBL1956575)
Show SMILES C1CN(CCO1)c1ccc(Nc2ncc(-c3ccc4[nH]ccc4c3)n3ccnc23)cc1
Show InChI InChI=1S/C24H22N6O/c1-6-21-17(7-8-25-21)15-18(1)22-16-27-23(24-26-9-10-30(22)24)28-19-2-4-20(5-3-19)29-11-13-31-14-12-29/h1-10,15-16,25H,11-14H2,(H,27,28)
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Galapagos NV

Curated by ChEMBL


Assay Description
Inhibition of MAPKAPK5


Citation and Details
More data for this
Ligand-Target Pair
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