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Found 85 hits Enz. Inhib. hit(s) with Target = 'MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223043
PNG
(US9320737, IV.2)
Show SMILES COc1cccc2oc(cc12)-c1cnc2ccc(OCCCS(C)(=N)=O)nn12
Show InChI InChI=1S/C19H20N4O4S/c1-25-15-5-3-6-16-13(15)11-17(27-16)14-12-21-18-7-8-19(22-23(14)18)26-9-4-10-28(2,20)24/h3,5-8,11-12,20H,4,9-10H2,1-2H3
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n/an/a 2n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223030
PNG
(US9320737, III.3)
Show SMILES COc1cccc2oc(cc12)-c1cnc2ccc(OCCCS(C)(=O)=O)nn12
Show InChI InChI=1S/C19H19N3O5S/c1-25-15-5-3-6-16-13(15)11-17(27-16)14-12-20-18-7-8-19(21-22(14)18)26-9-4-10-28(2,23)24/h3,5-8,11-12H,4,9-10H2,1-2H3
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223024
PNG
(US9320737, II.1)
Show SMILES COc1cccc2oc(cc12)-c1cnc2ccc(OCCCS(C)=O)nn12
Show InChI InChI=1S/C19H19N3O4S/c1-24-15-5-3-6-16-13(15)11-17(26-16)14-12-20-18-7-8-19(21-22(14)18)25-9-4-10-27(2)23/h3,5-8,11-12H,4,9-10H2,1-2H3
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223045
PNG
(US9320737, IV.4)
Show SMILES CS(=N)(=O)CCCOc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C18H18N4O3S/c1-26(19,23)10-4-9-24-18-8-7-17-20-12-14(22(17)21-18)16-11-13-5-2-3-6-15(13)25-16/h2-3,5-8,11-12,19H,4,9-10H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223025
PNG
(US9320737, II.2)
Show SMILES CS(=O)CCCOc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C18H17N3O3S/c1-25(22)10-4-9-23-18-8-7-17-19-12-14(21(17)20-18)16-11-13-5-2-3-6-15(13)24-16/h2-3,5-8,11-12H,4,9-10H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223029
PNG
(US9320737, III.2)
Show SMILES COc1ccc2oc(cc2c1)-c1cnc2ccc(OCCCS(C)(=O)=O)nn12
Show InChI InChI=1S/C19H19N3O5S/c1-25-14-4-5-16-13(10-14)11-17(27-16)15-12-20-18-6-7-19(21-22(15)18)26-8-3-9-28(2,23)24/h4-7,10-12H,3,8-9H2,1-2H3
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223028
PNG
(US9320737, III.1)
Show SMILES CS(=O)(=O)CCCOc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C18H17N3O4S/c1-26(22,23)10-4-9-24-18-8-7-17-19-12-14(21(17)20-18)16-11-13-5-2-3-6-15(13)25-16/h2-3,5-8,11-12H,4,9-10H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223026
PNG
(US9320737, II.3)
Show SMILES CS(=O)CCCCOc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C19H19N3O3S/c1-26(23)11-5-4-10-24-19-9-8-18-20-13-15(22(18)21-19)17-12-14-6-2-3-7-16(14)25-17/h2-3,6-9,12-13H,4-5,10-11H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223031
PNG
(US9320737, III.4)
Show SMILES CS(=O)(=O)CCCOc1ccc2ncc(-c3cc4cc(F)ccc4o3)n2n1
Show InChI InChI=1S/C18H16FN3O4S/c1-27(23,24)8-2-7-25-18-6-5-17-20-11-14(22(17)21-18)16-10-12-9-13(19)3-4-15(12)26-16/h3-6,9-11H,2,7-8H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223050
PNG
(US9320737, IV.8)
Show SMILES CS(=O)(CCCOc1ccc2ncc(-c3cc4ccccc4o3)n2n1)=NC#N
Show InChI InChI=1S/C19H17N5O3S/c1-28(25,22-13-20)10-4-9-26-19-8-7-18-21-12-15(24(18)23-19)17-11-14-5-2-3-6-16(14)27-17/h2-3,5-8,11-12H,4,9-10H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223048
PNG
(US9320737, IV.6)
Show SMILES CS(=N)(=O)CCCCOc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C19H20N4O3S/c1-27(20,24)11-5-4-10-25-19-9-8-18-21-13-15(23(18)22-19)17-12-14-6-2-3-7-16(14)26-17/h2-3,6-9,12-13,20H,4-5,10-11H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223042
PNG
(US9320737, IV.1)
Show SMILES COc1cccc2oc(cc12)-c1cnc2ccc(OCCCS(C)(=O)=NC(=O)C(F)(F)F)nn12
Show InChI InChI=1S/C21H19F3N4O5S/c1-31-15-5-3-6-16-13(15)11-17(33-16)14-12-25-18-7-8-19(26-28(14)18)32-9-4-10-34(2,30)27-20(29)21(22,23)24/h3,5-8,11-12H,4,9-10H2,1-2H3
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223051
PNG
(US9320737, IV.9)
Show SMILES COc1nccc2oc(cc12)-c1cnc2ccc(OCCCS(C)(=O)=NC#N)nn12
Show InChI InChI=1S/C19H18N6O4S/c1-27-19-13-10-16(29-15(13)6-7-21-19)14-11-22-17-4-5-18(24-25(14)17)28-8-3-9-30(2,26)23-12-20/h4-7,10-11H,3,8-9H2,1-2H3
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223052
PNG
(US9320737, IV.10)
Show SMILES COc1nccc2oc(cc12)-c1cnc2ccc(OCCCS(C)(=N)=O)nn12
Show InChI InChI=1S/C18H19N5O4S/c1-25-18-12-10-15(27-14(12)6-7-20-18)13-11-21-16-4-5-17(22-23(13)16)26-8-3-9-28(2,19)24/h4-7,10-11,19H,3,8-9H2,1-2H3
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223027
PNG
(US9320737, II.4)
Show SMILES CS(=O)CCOc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C17H15N3O3S/c1-24(21)9-8-22-17-7-6-16-18-11-13(20(16)19-17)15-10-12-4-2-3-5-14(12)23-15/h2-7,10-11H,8-9H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223021
PNG
(US9320737, I.2)
Show SMILES CSCCCOc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C18H17N3O2S/c1-24-10-4-9-22-18-8-7-17-19-12-14(21(17)20-18)16-11-13-5-2-3-6-15(13)23-16/h2-3,5-8,11-12H,4,9-10H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM211961
PNG
(US9290482, 1)
Show SMILES COc1nccc2oc(cc12)-c1cnc2ccc(OC[C@H]3CNCCO3)nn12
Show InChI InChI=1S/C19H19N5O4/c1-25-19-13-8-16(28-15(13)4-5-21-19)14-10-22-17-2-3-18(23-24(14)17)27-11-12-9-20-6-7-26-12/h2-5,8,10,12,20H,6-7,9,11H2,1H3/t12-/m1/s1
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl nL of a 100fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384well microtiter plate ...


US Patent US9290482 (2016)


BindingDB Entry DOI: 10.7270/Q2B856ZD
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223037
PNG
(US9320737, III.10)
Show SMILES Cc1cc2ncc(-c3cc4ccccc4o3)n2nc1OCCCS(C)(=O)=O
Show InChI InChI=1S/C19H19N3O4S/c1-13-10-18-20-12-15(17-11-14-6-3-4-7-16(14)26-17)22(18)21-19(13)25-8-5-9-27(2,23)24/h3-4,6-7,10-12H,5,8-9H2,1-2H3
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223039
PNG
(US9320737, III.12)
Show SMILES COc1nccc2oc(cc12)-c1cnc2ccc(OCCCS(C)(=O)=O)nn12
Show InChI InChI=1S/C18H18N4O5S/c1-25-18-12-10-15(27-14(12)6-7-19-18)13-11-20-16-4-5-17(21-22(13)16)26-8-3-9-28(2,23)24/h4-7,10-11H,3,8-9H2,1-2H3
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223044
PNG
(US9320737, IV.3)
Show SMILES CS(=O)(CCCOc1ccc2ncc(-c3cc4ccccc4o3)n2n1)=NC(=O)C(F)(F)F
Show InChI InChI=1S/C20H17F3N4O4S/c1-32(29,26-19(28)20(21,22)23)10-4-9-30-18-8-7-17-24-12-14(27(17)25-18)16-11-13-5-2-3-6-15(13)31-16/h2-3,5-8,11-12H,4,9-10H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223047
PNG
(US9320737, IV.5)
Show SMILES CS(=O)(CCCCOc1ccc2ncc(-c3cc4ccccc4o3)n2n1)=NC(=O)C(F)(F)F
Show InChI InChI=1S/C21H19F3N4O4S/c1-33(30,27-20(29)21(22,23)24)11-5-4-10-31-19-9-8-18-25-13-15(28(18)26-19)17-12-14-6-2-3-7-16(14)32-17/h2-3,6-9,12-13H,4-5,10-11H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223032
PNG
(US9320737, III.5)
Show SMILES CS(=O)(=O)CCCOc1ccc2ncc(-c3cc4cc(Cl)ccc4o3)n2n1
Show InChI InChI=1S/C18H16ClN3O4S/c1-27(23,24)8-2-7-25-18-6-5-17-20-11-14(22(17)21-18)16-10-12-9-13(19)3-4-15(12)26-16/h3-6,9-11H,2,7-8H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223023
PNG
(US9320737, I.4)
Show SMILES CSCCOc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C17H15N3O2S/c1-23-9-8-21-17-7-6-16-18-11-13(20(16)19-17)15-10-12-4-2-3-5-14(12)22-15/h2-7,10-11H,8-9H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM176795
PNG
(US9675612, 33 {7-[(6-Methoxy-1H-indazol-5-yl)amino...)
Show SMILES COc1cc2[nH]ncc2cc1Nc1ncnc2sc(nc12)C(=O)N1CCCCC1
Show InChI InChI=1S/C19H19N7O2S/c1-28-14-8-12-11(9-22-25-12)7-13(14)23-16-15-17(21-10-20-16)29-18(24-15)19(27)26-5-3-2-4-6-26/h7-10H,2-6H2,1H3,(H,22,25)(H,20,21,23)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223036
PNG
(US9320737, III.9)
Show SMILES CS(=O)(=O)CCCOc1ccc2ncc(-c3cc4c(F)cccc4o3)n2n1
Show InChI InChI=1S/C18H16FN3O4S/c1-27(23,24)9-3-8-25-18-7-6-17-20-11-14(22(17)21-18)16-10-12-13(19)4-2-5-15(12)26-16/h2,4-7,10-11H,3,8-9H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223038
PNG
(US9320737, III.11)
Show SMILES CS(=O)(=O)CCCOc1nn2c(cnc2cc1-c1ccccc1)-c1cc2ccccc2o1
Show InChI InChI=1S/C24H21N3O4S/c1-32(28,29)13-7-12-30-24-19(17-8-3-2-4-9-17)15-23-25-16-20(27(23)26-24)22-14-18-10-5-6-11-21(18)31-22/h2-6,8-11,14-16H,7,12-13H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM176749
PNG
(US9675612, 4 2-Benzyl-N-(6-methoxy-1H-indazol-5-yl...)
Show SMILES COc1cc2[nH]ncc2cc1Nc1ncnc2sc(Cc3ccccc3)nc12
Show InChI InChI=1S/C20H16N6OS/c1-27-16-9-14-13(10-23-26-14)8-15(16)24-19-18-20(22-11-21-19)28-17(25-18)7-12-5-3-2-4-6-12/h2-6,8-11H,7H2,1H3,(H,23,26)(H,21,22,24)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223020
PNG
(US9320737, I.1)
Show SMILES COc1cccc2oc(cc12)-c1cnc2ccc(OCCCSC)nn12
Show InChI InChI=1S/C19H19N3O3S/c1-23-15-5-3-6-16-13(15)11-17(25-16)14-12-20-18-7-8-19(21-22(14)18)24-9-4-10-26-2/h3,5-8,11-12H,4,9-10H2,1-2H3
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM176754
PNG
(US9675612, 5 N-(6-Methoxy-1H-indazol-5-yl)-2-(meth...)
Show SMILES COCc1nc2c(Nc3cc4cn[nH]c4cc3OC)ncnc2s1
Show InChI InChI=1S/C15H14N6O2S/c1-22-6-12-20-13-14(16-7-17-15(13)24-12)19-10-3-8-5-18-21-9(8)4-11(10)23-2/h3-5,7H,6H2,1-2H3,(H,18,21)(H,16,17,19)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223022
PNG
(US9320737, I.3)
Show SMILES CSCCCCOc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C19H19N3O2S/c1-25-11-5-4-10-23-19-9-8-18-20-13-15(22(18)21-19)17-12-14-6-2-3-7-16(14)24-17/h2-3,6-9,12-13H,4-5,10-11H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223040
PNG
(US9320737, III.13)
Show SMILES CS(=O)(=O)CCCOc1ccc2ncc(-c3cc4cnccc4o3)n2n1
Show InChI InChI=1S/C17H16N4O4S/c1-26(22,23)8-2-7-24-17-4-3-16-19-11-13(21(16)20-17)15-9-12-10-18-6-5-14(12)25-15/h3-6,9-11H,2,7-8H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM211962
PNG
(US9290482, 2)
Show SMILES COc1nccc2oc(cc12)-c1cnc2ccc(OCC3CNC3)nn12
Show InChI InChI=1S/C18H17N5O3/c1-24-18-12-6-15(26-14(12)4-5-20-18)13-9-21-16-2-3-17(22-23(13)16)25-10-11-7-19-8-11/h2-6,9,11,19H,7-8,10H2,1H3
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl nL of a 100fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384well microtiter plate ...


US Patent US9290482 (2016)


BindingDB Entry DOI: 10.7270/Q2B856ZD
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM211963
PNG
(US9290482, 3)
Show SMILES CN[C@H](C)COc1ccc2ncc(-c3cc4c(OC)nccc4o3)n2n1
Show InChI InChI=1S/C18H19N5O3/c1-11(19-2)10-25-17-5-4-16-21-9-13(23(16)22-17)15-8-12-14(26-15)6-7-20-18(12)24-3/h4-9,11,19H,10H2,1-3H3/t11-/m1/s1
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl nL of a 100fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384well microtiter plate ...


US Patent US9290482 (2016)


BindingDB Entry DOI: 10.7270/Q2B856ZD
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM176814
PNG
(US9675612, 47 N-[3-(Dimethylamino)-3-oxopropyl]-7-...)
Show SMILES CC(C)Oc1cc2[nH]ncc2cc1Nc1ncnc2sc(nc12)C(=O)N(C)CCC(=O)N(C)C
Show InChI InChI=1S/C22H26N8O3S/c1-12(2)33-16-9-14-13(10-25-28-14)8-15(16)26-19-18-20(24-11-23-19)34-21(27-18)22(32)30(5)7-6-17(31)29(3)4/h8-12H,6-7H2,1-5H3,(H,25,28)(H,23,24,26)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM176796
PNG
(US9675612, 34 {7-[(6-Ethoxy-1H-indazol-5-yl)amino]...)
Show SMILES CCOc1cc2[nH]ncc2cc1Nc1ncnc2sc(nc12)C(=O)N1CCCCC1
Show InChI InChI=1S/C20H21N7O2S/c1-2-29-15-9-13-12(10-23-26-13)8-14(15)24-17-16-18(22-11-21-17)30-19(25-16)20(28)27-6-4-3-5-7-27/h8-11H,2-7H2,1H3,(H,23,26)(H,21,22,24)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM176767
PNG
(US9675612, 11 2-Benzyl-N-(1H-indazol-5-yl)[1,3]thi...)
Show SMILES C(c1nc2c(Nc3ccc4[nH]ncc4c3)ncnc2s1)c1ccccc1
Show InChI InChI=1S/C19H14N6S/c1-2-4-12(5-3-1)8-16-24-17-18(20-11-21-19(17)26-16)23-14-6-7-15-13(9-14)10-22-25-15/h1-7,9-11H,8H2,(H,22,25)(H,20,21,23)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM176763
PNG
(US9675612, 9 2-(Cyclopropylmethyl)-N-(1H-indazol-5...)
Show SMILES C(C1CC1)c1nc2c(Nc3ccc4[nH]ncc4c3)ncnc2s1
Show InChI InChI=1S/C16H14N6S/c1-2-9(1)5-13-21-14-15(17-8-18-16(14)23-13)20-11-3-4-12-10(6-11)7-19-22-12/h3-4,6-9H,1-2,5H2,(H,19,22)(H,17,18,20)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM176777
PNG
(US9675612, 20 2-[(Benzyloxy)methyl]-N-(6-methoxy-1...)
Show SMILES COc1cc2[nH]ncc2cc1Nc1ncnc2sc(COCc3ccccc3)nc12
Show InChI InChI=1S/C21H18N6O2S/c1-28-17-8-15-14(9-24-27-15)7-16(17)25-20-19-21(23-12-22-20)30-18(26-19)11-29-10-13-5-3-2-4-6-13/h2-9,12H,10-11H2,1H3,(H,24,27)(H,22,23,25)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM176745
PNG
(US9675612, 1 6-{[2-(Cyclopropylmethyl)[1,3]thiazol...)
Show SMILES O=c1[nH]c2ccc(Nc3ncnc4sc(CC5CC5)nc34)cc2s1
Show InChI InChI=1S/C16H13N5OS2/c22-16-20-10-4-3-9(6-11(10)23-16)19-14-13-15(18-7-17-14)24-12(21-13)5-8-1-2-8/h3-4,6-8H,1-2,5H2,(H,20,22)(H,17,18,19)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM176779
PNG
(US9675612, 22 N-(6-Methoxy-1H-indazol-5-yl)-2-(2-p...)
Show SMILES COc1cc2[nH]ncc2cc1Nc1ncnc2sc(CCc3ccccc3)nc12
Show InChI InChI=1S/C21H18N6OS/c1-28-17-10-15-14(11-24-27-15)9-16(17)25-20-19-21(23-12-22-20)29-18(26-19)8-7-13-5-3-2-4-6-13/h2-6,9-12H,7-8H2,1H3,(H,24,27)(H,22,23,25)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM176791
PNG
(US9675612, 30 7-[(6-Ethoxy-1H-indazol-5-yl)amino]-...)
Show SMILES CCOc1cc2[nH]ncc2cc1Nc1ncnc2sc(nc12)C(=O)N(C)C
Show InChI InChI=1S/C17H17N7O2S/c1-4-26-12-6-10-9(7-20-23-10)5-11(12)21-14-13-15(19-8-18-14)27-16(22-13)17(25)24(2)3/h5-8H,4H2,1-3H3,(H,20,23)(H,18,19,21)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223049
PNG
(US9320737, IV.7)
Show SMILES CS(=O)(CCOc1ccc2ncc(-c3cc4ccccc4o3)n2n1)=NC(=O)C(F)(F)F
Show InChI InChI=1S/C19H15F3N4O4S/c1-31(28,25-18(27)19(20,21)22)9-8-29-17-7-6-16-23-11-13(26(16)24-17)15-10-12-4-2-3-5-14(12)30-15/h2-7,10-11H,8-9H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM176772
PNG
(US9675612, 15 N-(6-Methoxy-1H-indazol-5-yl)[1,3]th...)
Show SMILES COc1cc2[nH]ncc2cc1Nc1ncnc2scnc12
Show InChI InChI=1S/C13H10N6OS/c1-20-10-3-8-7(4-17-19-8)2-9(10)18-12-11-13(15-5-14-12)21-6-16-11/h2-6H,1H3,(H,17,19)(H,14,15,18)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM211968
PNG
(US9290482, 8)
Show SMILES COc1nccc2oc(cc12)-c1cnc2ccc(OCC3CCCCN3)nn12
Show InChI InChI=1S/C20H21N5O3/c1-26-20-14-10-17(28-16(14)7-9-22-20)15-11-23-18-5-6-19(24-25(15)18)27-12-13-4-2-3-8-21-13/h5-7,9-11,13,21H,2-4,8,12H2,1H3
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl nL of a 100fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384well microtiter plate ...


US Patent US9290482 (2016)


BindingDB Entry DOI: 10.7270/Q2B856ZD
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223033
PNG
(US9320737, III.6)
Show SMILES CS(=O)(=O)CCCOc1ccc2ncc(-c3cc4cccc(F)c4o3)n2n1
Show InChI InChI=1S/C18H16FN3O4S/c1-27(23,24)9-3-8-25-17-7-6-16-20-11-14(22(16)21-17)15-10-12-4-2-5-13(19)18(12)26-15/h2,4-7,10-11H,3,8-9H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM176803
PNG
(US9675612, 40 N-[3-(Dimethylamino)-3-oxopropyl]-7-...)
Show SMILES CN(C)C(=O)CCN(C)C(=O)c1nc2c(Nc3ccc4[nH]ncc4c3)ncnc2s1
Show InChI InChI=1S/C19H20N8O2S/c1-26(2)14(28)6-7-27(3)19(29)18-24-15-16(20-10-21-17(15)30-18)23-12-4-5-13-11(8-12)9-22-25-13/h4-5,8-10H,6-7H2,1-3H3,(H,22,25)(H,20,21,23)
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n/an/a 49n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM176780
PNG
(US9675612, 23 N-(1H-indazol-5-yl)-2-(2-phenylethyl...)
Show SMILES C(Cc1ccccc1)c1nc2c(Nc3ccc4[nH]ncc4c3)ncnc2s1
Show InChI InChI=1S/C20H16N6S/c1-2-4-13(5-3-1)6-9-17-25-18-19(21-12-22-20(18)27-17)24-15-7-8-16-14(10-15)11-23-26-16/h1-5,7-8,10-12H,6,9H2,(H,23,26)(H,21,22,24)
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n/an/a 51n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM176807
PNG
(US9675612, 44 N,N-Dimethyl-7-{[6-(propan-2-yloxy)-...)
Show SMILES CC(C)Oc1cc2[nH]ncc2cc1Nc1ncnc2sc(nc12)C(=O)N(C)C
Show InChI InChI=1S/C18H19N7O2S/c1-9(2)27-13-6-11-10(7-21-24-11)5-12(13)22-15-14-16(20-8-19-15)28-17(23-14)18(26)25(3)4/h5-9H,1-4H3,(H,21,24)(H,19,20,22)
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n/an/a 52n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM176766
PNG
(US9675612, 10 2-Cyclobutyl-N-(1H-indazol-5-yl)[1,3...)
Show SMILES C1CC(C1)c1nc2c(Nc3ccc4[nH]ncc4c3)ncnc2s1
Show InChI InChI=1S/C16H14N6S/c1-2-9(3-1)15-21-13-14(17-8-18-16(13)23-15)20-11-4-5-12-10(6-11)7-19-22-12/h4-9H,1-3H2,(H,19,22)(H,17,18,20)
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n/an/a 54n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM176761
PNG
(US9675612, 8 2-Cyclohexyl-N-(1H-indazol-5-yl)[1,3]...)
Show SMILES C1CCC(CC1)c1nc2c(Nc3ccc4[nH]ncc4c3)ncnc2s1
Show InChI InChI=1S/C18H18N6S/c1-2-4-11(5-3-1)17-23-15-16(19-10-20-18(15)25-17)22-13-6-7-14-12(8-13)9-21-24-14/h6-11H,1-5H2,(H,21,24)(H,19,20,22)
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n/an/a 56n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
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