BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 210 hits Enz. Inhib. hit(s) with Target = 'MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223024
PNG
(US9320737, II.1)
Show SMILES COc1cccc2oc(cc12)-c1cnc2ccc(OCCCS(C)=O)nn12
Show InChI InChI=1/C19H19N3O4S/c1-24-15-5-3-6-16-13(15)11-17(26-16)14-12-20-18-7-8-19(21-22(14)18)25-9-4-10-27(2)23/h3,5-8,11-12H,4,9-10H2,1-2H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2n/an/an/an/a7.522



Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223043
PNG
(US9320737, IV.2)
Show SMILES COc1cccc2oc(cc12)-c1cnc2ccc(OCCCS(C)(=N)=O)nn12
Show InChI InChI=1/C19H20N4O4S/c1-25-15-5-3-6-16-13(15)11-17(27-16)14-12-21-18-7-8-19(22-23(14)18)26-9-4-10-28(2,20)24/h3,5-8,11-12,20H,4,9-10H2,1-2H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2n/an/an/an/a7.522



Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223030
PNG
(US9320737, III.3)
Show SMILES COc1cccc2oc(cc12)-c1cnc2ccc(OCCCS(C)(=O)=O)nn12
Show InChI InChI=1S/C19H19N3O5S/c1-25-15-5-3-6-16-13(15)11-17(27-16)14-12-20-18-7-8-19(21-22(14)18)26-9-4-10-28(2,23)24/h3,5-8,11-12H,4,9-10H2,1-2H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2n/an/an/an/a7.522



Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337234
PNG
(N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-...)
Show SMILES OC(C(=O)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1cccnc1
Show InChI InChI=1/C21H15N5O3/c27-20(14-5-3-9-22-11-14)21(28)24-18-7-8-19-23-12-15(26(19)25-18)17-10-13-4-1-2-6-16(13)29-17/h1-12,20,27H,(H,24,25,28)
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 3n/an/an/an/an/an/a



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.092
BindingDB Entry DOI: 10.7270/Q2D79DHV
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337240
PNG
(N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-...)
Show SMILES O=C(CCc1cccnc1)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C22H17N5O2/c28-22(10-7-15-4-3-11-23-13-15)25-20-8-9-21-24-14-17(27(21)26-20)19-12-16-5-1-2-6-18(16)29-19/h1-6,8-9,11-14H,7,10H2,(H,25,26,28)
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 3n/an/an/an/an/an/a



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.092
BindingDB Entry DOI: 10.7270/Q2D79DHV
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337242
PNG
((5S)-1-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridaz...)
Show SMILES OC[C@@H]1CCC(=O)N1c1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1/C19H16N4O3/c24-11-13-5-8-19(25)22(13)18-7-6-17-20-10-14(23(17)21-18)16-9-12-3-1-2-4-15(12)26-16/h1-4,6-7,9-10,13,24H,5,8,11H2/t13-/s2
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 3n/an/an/an/an/an/a



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.092
BindingDB Entry DOI: 10.7270/Q2D79DHV
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337246
PNG
((2R)-2-hydroxy-N-[3-(4-methoxyfuro[3,2-c]pyridin-2...)
Show SMILES COc1nccc2oc(cc12)-c1cnc2ccc(NC(=O)[C@@H](C)O)nn12
Show InChI InChI=1/C17H15N5O4/c1-9(23)16(24)20-14-3-4-15-19-8-11(22(15)21-14)13-7-10-12(26-13)5-6-18-17(10)25-2/h3-9,23H,1-2H3,(H,20,21,24)/t9-/s2
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 3n/an/an/an/an/an/a



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.092
BindingDB Entry DOI: 10.7270/Q2D79DHV
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337234
PNG
(N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-...)
Show SMILES OC(C(=O)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1cccnc1
Show InChI InChI=1/C21H15N5O3/c27-20(14-5-3-9-22-11-14)21(28)24-18-7-8-19-23-12-15(26(19)25-18)17-10-13-4-1-2-6-16(13)29-17/h1-12,20,27H,(H,24,25,28)
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 3n/an/an/an/an/an/a



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.092
BindingDB Entry DOI: 10.7270/Q2D79DHV
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337240
PNG
(N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-...)
Show SMILES O=C(CCc1cccnc1)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C22H17N5O2/c28-22(10-7-15-4-3-11-23-13-15)25-20-8-9-21-24-14-17(27(21)26-20)19-12-16-5-1-2-6-18(16)29-19/h1-6,8-9,11-14H,7,10H2,(H,25,26,28)
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 3n/an/an/an/an/an/a



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.092
BindingDB Entry DOI: 10.7270/Q2D79DHV
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337242
PNG
((5S)-1-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridaz...)
Show SMILES OC[C@@H]1CCC(=O)N1c1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1/C19H16N4O3/c24-11-13-5-8-19(25)22(13)18-7-6-17-20-10-14(23(17)21-18)16-9-12-3-1-2-4-15(12)26-16/h1-4,6-7,9-10,13,24H,5,8,11H2/t13-/s2
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 3n/an/an/an/an/an/a



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.092
BindingDB Entry DOI: 10.7270/Q2D79DHV
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337246
PNG
((2R)-2-hydroxy-N-[3-(4-methoxyfuro[3,2-c]pyridin-2...)
Show SMILES COc1nccc2oc(cc12)-c1cnc2ccc(NC(=O)[C@@H](C)O)nn12
Show InChI InChI=1/C17H15N5O4/c1-9(23)16(24)20-14-3-4-15-19-8-11(22(15)21-14)13-7-10-12(26-13)5-6-18-17(10)25-2/h3-9,23H,1-2H3,(H,20,21,24)/t9-/s2
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 3n/an/an/an/an/an/a



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.092
BindingDB Entry DOI: 10.7270/Q2D79DHV
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223025
PNG
(US9320737, II.2)
Show SMILES CS(=O)CCCOc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1/C18H17N3O3S/c1-25(22)10-4-9-23-18-8-7-17-19-12-14(21(17)20-18)16-11-13-5-2-3-6-15(13)24-16/h2-3,5-8,11-12H,4,9-10H2,1H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4n/an/an/an/a7.522



Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223045
PNG
(US9320737, IV.4)
Show SMILES CS(=N)(=O)CCCOc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1/C18H18N4O3S/c1-26(19,23)10-4-9-24-18-8-7-17-20-12-14(22(17)21-18)16-11-13-5-2-3-6-15(13)25-16/h2-3,5-8,11-12,19H,4,9-10H2,1H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4n/an/an/an/a7.522



Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337236
PNG
(N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-...)
Show SMILES OC(C1CCOCC1)C(=O)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1/C21H20N4O4/c26-20(13-7-9-28-10-8-13)21(27)23-18-5-6-19-22-12-15(25(19)24-18)17-11-14-3-1-2-4-16(14)29-17/h1-6,11-13,20,26H,7-10H2,(H,23,24,27)
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 4n/an/an/an/an/an/a



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.092
BindingDB Entry DOI: 10.7270/Q2D79DHV
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337244
PNG
((2R)N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridaz...)
Show SMILES C[C@@H](O)C(=O)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1/C17H14N4O3/c1-10(22)17(23)19-15-6-7-16-18-9-12(21(16)20-15)14-8-11-4-2-3-5-13(11)24-14/h2-10,22H,1H3,(H,19,20,23)/t10-/s2
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 4n/an/an/an/an/an/a



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.092
BindingDB Entry DOI: 10.7270/Q2D79DHV
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337248
PNG
(N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-...)
Show SMILES CC(C)CC(=O)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C19H18N4O2/c1-12(2)9-19(24)21-17-7-8-18-20-11-14(23(18)22-17)16-10-13-5-3-4-6-15(13)25-16/h3-8,10-12H,9H2,1-2H3,(H,21,22,24)
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 4n/an/an/an/an/an/a



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.092
BindingDB Entry DOI: 10.7270/Q2D79DHV
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM343675
PNG
(6-Chloro-3-(5-methoxy-1-benzofuran-2-yl)imidazo[1,...)
Show SMILES CC(C)(C)CNCCCOc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C22H26N4O2/c1-22(2,3)15-23-11-6-12-27-21-10-9-20-24-14-17(26(20)25-21)19-13-16-7-4-5-8-18(16)28-19/h4-5,7-10,13-14,23H,6,11-12,15H2,1-3H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 4n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay 50 nL of a 100fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384well microtiter plate (Gr...


US Patent US9777004 (2017)


Article DOI: 10.1016/j.jmb.2004.09.032
BindingDB Entry DOI: 10.7270/Q2B27XDM
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337244
PNG
((2R)N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridaz...)
Show SMILES C[C@@H](O)C(=O)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1/C17H14N4O3/c1-10(22)17(23)19-15-6-7-16-18-9-12(21(16)20-15)14-8-11-4-2-3-5-13(11)24-14/h2-10,22H,1H3,(H,19,20,23)/t10-/s2
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 4n/an/an/an/an/an/a



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.092
BindingDB Entry DOI: 10.7270/Q2D79DHV
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337248
PNG
(N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-...)
Show SMILES CC(C)CC(=O)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C19H18N4O2/c1-12(2)9-19(24)21-17-7-8-18-20-11-14(23(18)22-17)16-10-13-5-3-4-6-15(13)25-16/h3-8,10-12H,9H2,1-2H3,(H,21,22,24)
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 4n/an/an/an/an/an/a



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.092
BindingDB Entry DOI: 10.7270/Q2D79DHV
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM343673
PNG
(3-(1-Benzofuran-2-yl)-6-[2-(morpholin-2-yl)ethoxy]...)
Show SMILES C(CC1CNCCO1)Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1/C20H20N4O3/c1-2-4-17-14(3-1)11-18(27-17)16-13-22-19-5-6-20(23-24(16)19)26-9-7-15-12-21-8-10-25-15/h1-6,11,13,15,21H,7-10,12H2
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 4n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay 50 nL of a 100fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384well microtiter plate (Gr...


US Patent US9777004 (2017)


Article DOI: 10.1016/j.jmb.2004.09.032
BindingDB Entry DOI: 10.7270/Q2B27XDM
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM343674
PNG
(6-Chloro-3-(4-methoxy-1-benzofuran-2-yl)imidazo[1,...)
Show SMILES C(Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1)C1CNCCO1
Show InChI InChI=1/C19H18N4O3/c1-2-4-16-13(3-1)9-17(26-16)15-11-21-18-5-6-19(22-23(15)18)25-12-14-10-20-7-8-24-14/h1-6,9,11,14,20H,7-8,10,12H2
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 4n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay 50 nL of a 100fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384well microtiter plate (Gr...


US Patent US9777004 (2017)


Article DOI: 10.1016/j.jmb.2004.09.032
BindingDB Entry DOI: 10.7270/Q2B27XDM
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337236
PNG
(N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-...)
Show SMILES OC(C1CCOCC1)C(=O)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1/C21H20N4O4/c26-20(13-7-9-28-10-8-13)21(27)23-18-5-6-19-22-12-15(25(19)24-18)17-11-14-3-1-2-4-16(14)29-17/h1-6,11-13,20,26H,7-10H2,(H,23,24,27)
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 4n/an/an/an/an/an/a



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.092
BindingDB Entry DOI: 10.7270/Q2D79DHV
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223026
PNG
(US9320737, II.3)
Show SMILES CS(=O)CCCCOc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1/C19H19N3O3S/c1-26(23)11-5-4-10-24-19-9-8-18-20-13-15(22(18)21-19)17-12-14-6-2-3-7-16(14)25-17/h2-3,6-9,12-13H,4-5,10-11H2,1H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5n/an/an/an/a7.522



Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223028
PNG
(US9320737, III.1)
Show SMILES CS(=O)(=O)CCCOc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C18H17N3O4S/c1-26(22,23)10-4-9-24-18-8-7-17-19-12-14(21(17)20-18)16-11-13-5-2-3-6-15(13)25-16/h2-3,5-8,11-12H,4,9-10H2,1H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5n/an/an/an/a7.522



Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223029
PNG
(US9320737, III.2)
Show SMILES COc1ccc2oc(cc2c1)-c1cnc2ccc(OCCCS(C)(=O)=O)nn12
Show InChI InChI=1S/C19H19N3O5S/c1-25-14-4-5-16-13(10-14)11-17(27-16)15-12-20-18-6-7-19(21-22(15)18)26-8-3-9-28(2,23)24/h4-7,10-12H,3,8-9H2,1-2H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5n/an/an/an/a7.522



Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337243
PNG
(N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-...)
Show SMILES OC(C1CC1)C(=O)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1/C19H16N4O3/c24-18(11-5-6-11)19(25)21-16-7-8-17-20-10-13(23(17)22-16)15-9-12-3-1-2-4-14(12)26-15/h1-4,7-11,18,24H,5-6H2,(H,21,22,25)
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 5n/an/an/an/an/an/a



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.092
BindingDB Entry DOI: 10.7270/Q2D79DHV
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337243
PNG
(N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-...)
Show SMILES OC(C1CC1)C(=O)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1/C19H16N4O3/c24-18(11-5-6-11)19(25)21-16-7-8-17-20-10-13(23(17)22-16)15-9-12-3-1-2-4-14(12)26-15/h1-4,7-11,18,24H,5-6H2,(H,21,22,25)
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 5n/an/an/an/an/an/a



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.092
BindingDB Entry DOI: 10.7270/Q2D79DHV
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337238
PNG
(N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-...)
Show SMILES O=C(Cc1cccnc1)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C21H15N5O2/c27-21(10-14-4-3-9-22-12-14)24-19-7-8-20-23-13-16(26(20)25-19)18-11-15-5-1-2-6-17(15)28-18/h1-9,11-13H,10H2,(H,24,25,27)
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 5n/an/an/an/an/an/a



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.092
BindingDB Entry DOI: 10.7270/Q2D79DHV
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337238
PNG
(N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-...)
Show SMILES O=C(Cc1cccnc1)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C21H15N5O2/c27-21(10-14-4-3-9-22-12-14)24-19-7-8-20-23-13-16(26(20)25-19)18-11-15-5-1-2-6-17(15)28-18/h1-9,11-13H,10H2,(H,24,25,27)
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 5n/an/an/an/an/an/a



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.092
BindingDB Entry DOI: 10.7270/Q2D79DHV
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337251
PNG
(N-[3-(1-benzofuran-2- yl)imidazo[1,2-b]pyridazin-6...)
Show SMILES Cn1cc(CCC(=O)Nc2ccc3ncc(-c4cc5ccccc5o4)n3n2)cn1
Show InChI InChI=1S/C21H18N6O2/c1-26-13-14(11-23-26)6-9-21(28)24-19-7-8-20-22-12-16(27(20)25-19)18-10-15-4-2-3-5-17(15)29-18/h2-5,7-8,10-13H,6,9H2,1H3,(H,24,25,28)
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 6n/an/an/an/an/an/a



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.092
BindingDB Entry DOI: 10.7270/Q2D79DHV
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM343673
PNG
(3-(1-Benzofuran-2-yl)-6-[2-(morpholin-2-yl)ethoxy]...)
Show SMILES C(CC1CNCCO1)Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1/C20H20N4O3/c1-2-4-17-14(3-1)11-18(27-17)16-13-22-19-5-6-20(23-24(16)19)26-9-7-15-12-21-8-10-25-15/h1-6,11,13,15,21H,7-10,12H2
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 6n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay 50 nL of a 100fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384well microtiter plate (Gr...


US Patent US9777004 (2017)


Article DOI: 10.1016/j.jmb.2004.09.032
BindingDB Entry DOI: 10.7270/Q2B27XDM
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM343677
PNG
(3-(1-Benzofuran-2-yl)-6-{2-[(3R)-morpholin-3-yl]et...)
Show SMILES C(C[C@@H]1COCCN1)Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1/C20H20N4O3/c1-2-4-17-14(3-1)11-18(27-17)16-12-22-19-5-6-20(23-24(16)19)26-9-7-15-13-25-10-8-21-15/h1-6,11-12,15,21H,7-10,13H2/t15-/s2
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 6n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay 50 nL of a 100fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384well microtiter plate (Gr...


US Patent US9777004 (2017)


Article DOI: 10.1016/j.jmb.2004.09.032
BindingDB Entry DOI: 10.7270/Q2B27XDM
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337251
PNG
(N-[3-(1-benzofuran-2- yl)imidazo[1,2-b]pyridazin-6...)
Show SMILES Cn1cc(CCC(=O)Nc2ccc3ncc(-c4cc5ccccc5o4)n3n2)cn1
Show InChI InChI=1S/C21H18N6O2/c1-26-13-14(11-23-26)6-9-21(28)24-19-7-8-20-22-12-16(27(20)25-19)18-10-15-4-2-3-5-17(15)29-18/h2-5,7-8,10-13H,6,9H2,1H3,(H,24,25,28)
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 6n/an/an/an/an/an/a



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.092
BindingDB Entry DOI: 10.7270/Q2D79DHV
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223031
PNG
(US9320737, III.4)
Show SMILES CS(=O)(=O)CCCOc1ccc2ncc(-c3cc4cc(F)ccc4o3)n2n1
Show InChI InChI=1S/C18H16FN3O4S/c1-27(23,24)8-2-7-25-18-6-5-17-20-11-14(22(17)21-18)16-10-12-9-13(19)3-4-15(12)26-16/h3-6,9-11H,2,7-8H2,1H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 7n/an/an/an/a7.522



Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223050
PNG
(US9320737, IV.8)
Show SMILES CS(=O)(CCCOc1ccc2ncc(-c3cc4ccccc4o3)n2n1)=NC#N
Show InChI InChI=1/C19H17N5O3S/c1-28(25,22-13-20)10-4-9-26-19-8-7-18-21-12-15(24(18)23-19)17-11-14-5-2-3-6-16(14)27-17/h2-3,5-8,11-12H,4,9-10H2,1H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 7n/an/an/an/a7.522



Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337233
PNG
(N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-...)
Show SMILES OC(C(=O)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1ccccc1
Show InChI InChI=1/C22H16N4O3/c27-21(14-6-2-1-3-7-14)22(28)24-19-10-11-20-23-13-16(26(20)25-19)18-12-15-8-4-5-9-17(15)29-18/h1-13,21,27H,(H,24,25,28)
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 7n/an/an/an/an/an/a



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.092
BindingDB Entry DOI: 10.7270/Q2D79DHV
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337235
PNG
(N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-...)
Show SMILES OC(C1CCCCC1)C(=O)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1/C22H22N4O3/c27-21(14-6-2-1-3-7-14)22(28)24-19-10-11-20-23-13-16(26(20)25-19)18-12-15-8-4-5-9-17(15)29-18/h4-5,8-14,21,27H,1-3,6-7H2,(H,24,25,28)
PDB

GoogleScholar
KEGG
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 7n/an/an/an/an/an/a



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.092
BindingDB Entry DOI: 10.7270/Q2D79DHV
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM343678
PNG
(3-{[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6...)
Show SMILES CC(C)NCCCOc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C20H22N4O2/c1-14(2)21-10-5-11-25-20-9-8-19-22-13-16(24(19)23-20)18-12-15-6-3-4-7-17(15)26-18/h3-4,6-9,12-14,21H,5,10-11H2,1-2H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 7n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay 50 nL of a 100fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384well microtiter plate (Gr...


US Patent US9777004 (2017)


Article DOI: 10.1016/j.jmb.2004.09.032
BindingDB Entry DOI: 10.7270/Q2B27XDM
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337233
PNG
(N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-...)
Show SMILES OC(C(=O)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1ccccc1
Show InChI InChI=1/C22H16N4O3/c27-21(14-6-2-1-3-7-14)22(28)24-19-10-11-20-23-13-16(26(20)25-19)18-12-15-8-4-5-9-17(15)29-18/h1-13,21,27H,(H,24,25,28)
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 7n/an/an/an/an/an/a



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.092
BindingDB Entry DOI: 10.7270/Q2D79DHV
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337235
PNG
(N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-...)
Show SMILES OC(C1CCCCC1)C(=O)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1/C22H22N4O3/c27-21(14-6-2-1-3-7-14)22(28)24-19-10-11-20-23-13-16(26(20)25-19)18-12-15-8-4-5-9-17(15)29-18/h4-5,8-14,21,27H,1-3,6-7H2,(H,24,25,28)
PDB

GoogleScholar
KEGG
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 7n/an/an/an/an/an/a



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.092
BindingDB Entry DOI: 10.7270/Q2D79DHV
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337237
PNG
(N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-...)
Show SMILES O=C(Cc1ccccn1)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C21H15N5O2/c27-21(12-15-6-3-4-10-22-15)24-19-8-9-20-23-13-16(26(20)25-19)18-11-14-5-1-2-7-17(14)28-18/h1-11,13H,12H2,(H,24,25,27)
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 7n/an/an/an/an/an/a



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.092
BindingDB Entry DOI: 10.7270/Q2D79DHV
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM343676
PNG
(2-{[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6...)
Show SMILES C(COc1ccc2ncc(-c3cc4ccccc4o3)n2n1)NCC1CC1
Show InChI InChI=1S/C20H20N4O2/c1-2-4-17-15(3-1)11-18(26-17)16-13-22-19-7-8-20(23-24(16)19)25-10-9-21-12-14-5-6-14/h1-4,7-8,11,13-14,21H,5-6,9-10,12H2
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 7n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay 50 nL of a 100fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384well microtiter plate (Gr...


US Patent US9777004 (2017)


Article DOI: 10.1016/j.jmb.2004.09.032
BindingDB Entry DOI: 10.7270/Q2B27XDM
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337237
PNG
(N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-...)
Show SMILES O=C(Cc1ccccn1)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C21H15N5O2/c27-21(12-15-6-3-4-10-22-15)24-19-8-9-20-23-13-16(26(20)25-19)18-11-14-5-1-2-7-17(14)28-18/h1-11,13H,12H2,(H,24,25,27)
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 7n/an/an/an/an/an/a



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.092
BindingDB Entry DOI: 10.7270/Q2D79DHV
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223048
PNG
(US9320737, IV.6)
Show SMILES CS(=N)(=O)CCCCOc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1/C19H20N4O3S/c1-27(20,24)11-5-4-10-25-19-9-8-18-21-13-15(23(18)22-19)17-12-14-6-2-3-7-16(14)26-17/h2-3,6-9,12-13,20H,4-5,10-11H2,1H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 8n/an/an/an/a7.522



Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337232
PNG
(N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-...)
Show SMILES O=C(Cc1ccccc1)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C22H16N4O2/c27-22(12-15-6-2-1-3-7-15)24-20-10-11-21-23-14-17(26(21)25-20)19-13-16-8-4-5-9-18(16)28-19/h1-11,13-14H,12H2,(H,24,25,27)
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 8n/an/an/an/an/an/a



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.092
BindingDB Entry DOI: 10.7270/Q2D79DHV
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337245
PNG
((2S)N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridaz...)
Show SMILES C[C@H](O)C(=O)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1/C17H14N4O3/c1-10(22)17(23)19-15-6-7-16-18-9-12(21(16)20-15)14-8-11-4-2-3-5-13(11)24-14/h2-10,22H,1H3,(H,19,20,23)/t10-/s2
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 8n/an/an/an/an/an/a



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.092
BindingDB Entry DOI: 10.7270/Q2D79DHV
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337250
PNG
(N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-...)
Show SMILES O=C(CCc1c[nH]cn1)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C20H16N6O2/c27-20(8-5-14-10-21-12-23-14)24-18-6-7-19-22-11-15(26(19)25-18)17-9-13-3-1-2-4-16(13)28-17/h1-4,6-7,9-12H,5,8H2,(H,21,23)(H,24,25,27)
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 8n/an/an/an/an/an/a



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.092
BindingDB Entry DOI: 10.7270/Q2D79DHV
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM343685
PNG
(N-(2-{[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazi...)
Show SMILES C(COc1ccc2ncc(-c3cc4ccccc4o3)n2n1)NC1CC1
Show InChI InChI=1S/C19H18N4O2/c1-2-4-16-13(3-1)11-17(25-16)15-12-21-18-7-8-19(22-23(15)18)24-10-9-20-14-5-6-14/h1-4,7-8,11-12,14,20H,5-6,9-10H2
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 8n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay 50 nL of a 100fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384well microtiter plate (Gr...


US Patent US9777004 (2017)


Article DOI: 10.1016/j.jmb.2004.09.032
BindingDB Entry DOI: 10.7270/Q2B27XDM
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337245
PNG
((2S)N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridaz...)
Show SMILES C[C@H](O)C(=O)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1/C17H14N4O3/c1-10(22)17(23)19-15-6-7-16-18-9-12(21(16)20-15)14-8-11-4-2-3-5-13(11)24-14/h2-10,22H,1H3,(H,19,20,23)/t10-/s2
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 8n/an/an/an/an/an/a



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.092
BindingDB Entry DOI: 10.7270/Q2D79DHV
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337250
PNG
(N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-...)
Show SMILES O=C(CCc1c[nH]cn1)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C20H16N6O2/c27-20(8-5-14-10-21-12-23-14)24-18-6-7-19-22-11-15(26(19)25-18)17-9-13-3-1-2-4-16(13)28-17/h1-4,6-7,9-12H,5,8H2,(H,21,23)(H,24,25,27)
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 8n/an/an/an/an/an/a



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.092
BindingDB Entry DOI: 10.7270/Q2D79DHV
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 210 total )  |  Next  |  Last  >>
Jump to: