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Compile Data Set for Download or QSAR

Found 420 hits Enz. Inhib. hit(s) with Target = 'MAP kinase-interacting serine/threonine-protein kinase MNK1'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50042936
PNG
(CHEMBL3355000)
Show SMILES COc1cc2[nH]ncc2cc1Nc1ncnc2[nH]c3CCC(Cc3c12)C(=O)NCc1ccccc1
Show InChI InChI=1S/C26H25N7O2/c1-35-22-11-20-17(13-30-33-20)10-21(22)32-25-23-18-9-16(7-8-19(18)31-24(23)28-14-29-25)26(34)27-12-15-5-3-2-4-6-15/h2-6,10-11,13-14,16H,7-9,12H2,1H3,(H,27,34)(H,30,33)(H2,28,29,31,32)
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n/an/a 1n/an/an/an/an/an/a



Dart Neuroscience LLC

Curated by ChEMBL


Assay Description
Inhibition of human full-length MKNK1 using biotin-Ahx-IKKRKLTRRKSLKG substrate by TR-FRET-based high ATP assay


ACS Med Chem Lett 6: 9-10 (2015)


Article DOI: 10.1021/ml5003025
BindingDB Entry DOI: 10.7270/Q2BP04DN
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50042938
PNG
(CHEMBL3355002)
Show SMILES CC(C)Oc1cc2[nH]ncc2cc1Nc1ncnc2[nH]c3CCC(Cc3c12)C(=O)NCCCS(C)(=O)=O
Show InChI InChI=1S/C25H31N7O4S/c1-14(2)36-21-11-19-16(12-29-32-19)10-20(21)31-24-22-17-9-15(25(33)26-7-4-8-37(3,34)35)5-6-18(17)30-23(22)27-13-28-24/h10-15H,4-9H2,1-3H3,(H,26,33)(H,29,32)(H2,27,28,30,31)
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Dart Neuroscience LLC

Curated by ChEMBL


Assay Description
Inhibition of human full-length MKNK1 using biotin-Ahx-IKKRKLTRRKSLKG substrate by TR-FRET-based high ATP assay


ACS Med Chem Lett 6: 9-10 (2015)


Article DOI: 10.1021/ml5003025
BindingDB Entry DOI: 10.7270/Q2BP04DN
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50042934
PNG
(CHEMBL3354998)
Show SMILES CC(C)Oc1cc2[nH]ncc2cc1Nc1ncnc2[nH]c3CCCCc3c12
Show InChI InChI=1S/C20H22N6O/c1-11(2)27-17-8-15-12(9-23-26-15)7-16(17)25-20-18-13-5-3-4-6-14(13)24-19(18)21-10-22-20/h7-11H,3-6H2,1-2H3,(H,23,26)(H2,21,22,24,25)
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n/an/a 5n/an/an/an/an/an/a



Dart Neuroscience LLC

Curated by ChEMBL


Assay Description
Inhibition of human full-length MKNK1 using biotin-Ahx-IKKRKLTRRKSLKG substrate by TR-FRET-based high ATP assay


ACS Med Chem Lett 6: 9-10 (2015)


Article DOI: 10.1021/ml5003025
BindingDB Entry DOI: 10.7270/Q2BP04DN
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50042933
PNG
(CHEMBL3354997)
Show SMILES COc1cc(Cl)c(Cl)cc1Nc1ncnc2[nH]c3CCC(Cc3c12)C(=O)NC1CC1
Show InChI InChI=1S/C21H21Cl2N5O2/c1-30-17-8-14(23)13(22)7-16(17)28-20-18-12-6-10(21(29)26-11-3-4-11)2-5-15(12)27-19(18)24-9-25-20/h7-11H,2-6H2,1H3,(H,26,29)(H2,24,25,27,28)
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Dart Neuroscience LLC

Curated by ChEMBL


Assay Description
Inhibition of human full-length MKNK1 using biotin-Ahx-IKKRKLTRRKSLKG substrate by TR-FRET-based high ATP assay


ACS Med Chem Lett 6: 9-10 (2015)


Article DOI: 10.1021/ml5003025
BindingDB Entry DOI: 10.7270/Q2BP04DN
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50042935
PNG
(CHEMBL3354999)
Show SMILES CCNC(=O)C1CCc2[nH]c3ncnc(Nc4cc5cn[nH]c5cc4OC)c3c2C1
Show InChI InChI=1S/C21H23N7O2/c1-3-22-21(29)11-4-5-14-13(6-11)18-19(26-14)23-10-24-20(18)27-16-7-12-9-25-28-15(12)8-17(16)30-2/h7-11H,3-6H2,1-2H3,(H,22,29)(H,25,28)(H2,23,24,26,27)
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Dart Neuroscience LLC

Curated by ChEMBL


Assay Description
Inhibition of human full-length MKNK1 using biotin-Ahx-IKKRKLTRRKSLKG substrate by TR-FRET-based high ATP assay


ACS Med Chem Lett 6: 9-10 (2015)


Article DOI: 10.1021/ml5003025
BindingDB Entry DOI: 10.7270/Q2BP04DN
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168281
PNG
(US9669031, 109 8-chloro-6-(pyrimidin-4-ylamino)spi...)
Show SMILES Clc1cc(Nc2ccncn2)c(=O)n2c1C(=O)NC21CCCCC1
Show InChI InChI=1S/C16H16ClN5O2/c17-10-8-11(20-12-4-7-18-9-19-12)15(24)22-13(10)14(23)21-16(22)5-2-1-3-6-16/h4,7-9H,1-3,5-6H2,(H,21,23)(H,18,19,20)
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n/an/a<10n/an/an/an/an/an/a



eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168282
PNG
(US9669031, 110 8-chloro-4′,4′-difluoro...)
Show SMILES FC1(F)CCC2(CC1)NC(=O)c1c(Cl)cc(Nc3ccncn3)c(=O)n21
Show InChI InChI=1S/C16H14ClF2N5O2/c17-9-7-10(22-11-1-6-20-8-21-11)14(26)24-12(9)13(25)23-16(24)4-2-15(18,19)3-5-16/h1,6-8H,2-5H2,(H,23,25)(H,20,21,22)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168283
PNG
(US9669031, 111 6-[(6-aminopyrimidin-4-yl)amino]-6&...)
Show SMILES CC(C)(C)OC(=O)Nc1cc(Nc2cc(Cl)c3C(=O)NC4(CCc5ccc(Cl)cc45)n3c2=O)ncn1
Show InChI InChI=1S/C24H22Cl2N6O4/c1-23(2,3)36-22(35)30-18-10-17(27-11-28-18)29-16-9-15(26)19-20(33)31-24(32(19)21(16)34)7-6-12-4-5-13(25)8-14(12)24/h4-5,8-11H,6-7H2,1-3H3,(H,31,33)(H2,27,28,29,30,35)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168284
PNG
(US9669031, 112 8-chloro-6-[(5-fluoropyrimidin-4-yl...)
Show SMILES Fc1cncnc1Nc1cc(Cl)c2C(=O)NC3(CCCCC3)n2c1=O
Show InChI InChI=1S/C16H15ClFN5O2/c17-9-6-11(21-13-10(18)7-19-8-20-13)15(25)23-12(9)14(24)22-16(23)4-2-1-3-5-16/h6-8H,1-5H2,(H,22,24)(H,19,20,21)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168285
PNG
(US9669031, 113 8-chloro-6-(pyrimidin-4-ylamino)spi...)
Show SMILES Clc1cc(Nc2ccncn2)c(=O)n2c1C(=O)NC21Cc2ccccc2C1=O
Show InChI InChI=1S/C19H12ClN5O3/c20-12-7-13(23-14-5-6-21-9-22-14)18(28)25-15(12)17(27)24-19(25)8-10-3-1-2-4-11(10)16(19)26/h1-7,9H,8H2,(H,24,27)(H,21,22,23)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168286
PNG
(US9669031, 114 6-((6-aminopyrimidin-4-yl)amino)-8-...)
Show SMILES CC(C)(C)OC(=O)Nc1cc(Nc2cc(Cl)c3C(=O)NC4(CCc5ccc(F)cc45)n3c2=O)ncn1
Show InChI InChI=1S/C24H22ClFN6O4/c1-23(2,3)36-22(35)30-18-10-17(27-11-28-18)29-16-9-15(25)19-20(33)31-24(32(19)21(16)34)7-6-12-4-5-13(26)8-14(12)24/h4-5,8-11H,6-7H2,1-3H3,(H,31,33)(H2,27,28,29,30,35)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168287
PNG
(US9669031, 115 8-chloro-6-[(5-chloropyrimidin-4-yl...)
Show SMILES Clc1cc(Nc2ncncc2Cl)c(=O)n2c1C(=O)NC21CCCCC1
Show InChI InChI=1S/C16H15Cl2N5O2/c17-9-6-11(21-13-10(18)7-19-8-20-13)15(25)23-12(9)14(24)22-16(23)4-2-1-3-5-16/h6-8H,1-5H2,(H,22,24)(H,19,20,21)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168288
PNG
(US9669031, 116 8-chloro-6-[(6-methylpyrimidin-4-yl...)
Show SMILES Cc1cc(Nc2cc(Cl)c3C(=O)NC4(CCCCC4)n3c2=O)ncn1
Show InChI InChI=1S/C17H18ClN5O2/c1-10-7-13(20-9-19-10)21-12-8-11(18)14-15(24)22-17(23(14)16(12)25)5-3-2-4-6-17/h7-9H,2-6H2,1H3,(H,22,24)(H,19,20,21)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168289
PNG
(US9669031, 117 6′-((7H-purin-6-yl)amino)-8&#...)
Show SMILES C[Si](C)(C)CCOCn1cnc2ncnc(Nc3cc(Cl)c4C(=O)NC5(CCCCC5)n4c3=O)c12
Show InChI InChI=1S/C23H30ClN7O3Si/c1-35(2,3)10-9-34-14-30-13-27-19-18(30)20(26-12-25-19)28-16-11-15(24)17-21(32)29-23(31(17)22(16)33)7-5-4-6-8-23/h11-13H,4-10,14H2,1-3H3,(H,29,32)(H,25,26,28)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168299
PNG
(US9669031, 126 6-((6-aminopyrimidin-4-yl)amino)-8-...)
Show SMILES Nc1cc(Nc2cc(Cl)c3C(=O)NC4(CNCNC4)n3c2=O)ncn1
Show InChI InChI=1S/C14H15ClN8O2/c15-7-1-8(21-10-2-9(16)19-6-20-10)13(25)23-11(7)12(24)22-14(23)3-17-5-18-4-14/h1-2,6,17-18H,3-5H2,(H,22,24)(H3,16,19,20,21)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168301
PNG
(US9669031, 127 6′-((1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES Clc1cc(Nc2ncnc3[nH]ncc23)c(=O)n2c1C(=O)NC21CCCCC1
Show InChI InChI=1S/C17H16ClN7O2/c18-10-6-11(22-13-9-7-21-24-14(9)20-8-19-13)16(27)25-12(10)15(26)23-17(25)4-2-1-3-5-17/h6-8H,1-5H2,(H,23,26)(H2,19,20,21,22,24)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168302
PNG
(US9669031, 128 6-[(6-aminopyrimidin-4-yl)amino]-8-...)
Show SMILES CN1CCC2(CC1)NC(=O)c1c(Cl)cc(Nc3cc(NC(=O)OC(C)(C)C)ncn3)c(=O)n21
Show InChI InChI=1S/C21H26ClN7O4/c1-20(2,3)33-19(32)26-15-10-14(23-11-24-15)25-13-9-12(22)16-17(30)27-21(29(16)18(13)31)5-7-28(4)8-6-21/h9-11H,5-8H2,1-4H3,(H,27,30)(H2,23,24,25,26,32)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168303
PNG
(US9669031, 129 8-chloro-1′-methyl-6-(pyrimid...)
Show SMILES CN1CCC2(CC1)NC(=O)c1c(Cl)cc(Nc3ccncn3)c(=O)n21
Show InChI InChI=1S/C16H17ClN6O2/c1-22-6-3-16(4-7-22)21-14(24)13-10(17)8-11(15(25)23(13)16)20-12-2-5-18-9-19-12/h2,5,8-9H,3-4,6-7H2,1H3,(H,21,24)(H,18,19,20)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168304
PNG
(US9669031, 130 1′,8-dimethyl-6-(pyrimidin-4-...)
Show SMILES CN1CCCC2(C1)NC(=O)c1c(C)cc(Nc3ccncn3)c(=O)n21
Show InChI InChI=1S/C17H20N6O2/c1-11-8-12(20-13-4-6-18-10-19-13)16(25)23-14(11)15(24)21-17(23)5-3-7-22(2)9-17/h4,6,8,10H,3,5,7,9H2,1-2H3,(H,21,24)(H,18,19,20)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168308
PNG
(US9669031, 142 4-((8′-chloro-1′,5̸...)
Show SMILES Clc1cc(Nc2ncncc2C#N)c(=O)n2c1C(=O)NC21CCCCC1
Show InChI InChI=1S/C17H15ClN6O2/c18-11-6-12(22-14-10(7-19)8-20-9-21-14)16(26)24-13(11)15(25)23-17(24)4-2-1-3-5-17/h6,8-9H,1-5H2,(H,23,25)(H,20,21,22)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168309
PNG
(US9669031, 143 8′-chloro-6′-((5-(1-met...)
Show SMILES Cn1cc(cn1)-c1cncnc1Nc1cc(Cl)c2C(=O)NC3(CCCCC3)n2c1=O
Show InChI InChI=1S/C20H20ClN7O2/c1-27-10-12(8-24-27)13-9-22-11-23-17(13)25-15-7-14(21)16-18(29)26-20(28(16)19(15)30)5-3-2-4-6-20/h7-11H,2-6H2,1H3,(H,26,29)(H,22,23,25)
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n/an/a<10n/an/an/an/an/an/a



eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168301
PNG
(US9669031, 127 6′-((1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES Clc1cc(Nc2ncnc3[nH]ncc23)c(=O)n2c1C(=O)NC21CCCCC1
Show InChI InChI=1S/C17H16ClN7O2/c18-10-6-11(22-13-9-7-21-24-14(9)20-8-19-13)16(27)25-12(10)15(26)23-17(25)4-2-1-3-5-17/h6-8H,1-5H2,(H,23,26)(H2,19,20,21,22,24)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168311
PNG
(US9669031, 146 8-chloro-6-(3H-triazolo[4,5-d]pyrim...)
Show SMILES CC(C)C(=O)N(COCC[Si](C)(C)C)c1ncnc2n(COCC[Si](C)(C)C)nnc12
Show InChI InChI=1S/C20H38N6O3Si2/c1-16(2)20(27)25(14-28-9-11-30(3,4)5)18-17-19(22-13-21-18)26(24-23-17)15-29-10-12-31(6,7)8/h13,16H,9-12,14-15H2,1-8H3
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168335
PNG
(US9669031, 170 6-[(6-aminopyrimidin-4-yl)amino]-1&...)
Show SMILES CN1CCCC2(C1)NC(=O)c1c(C)cc(Nc3cc(NC(=O)OC(C)(C)C)ncn3)c(=O)n21
Show InChI InChI=1S/C22H29N7O4/c1-13-9-14(25-15-10-16(24-12-23-15)26-20(32)33-21(2,3)4)19(31)29-17(13)18(30)27-22(29)7-6-8-28(5)11-22/h9-10,12H,6-8,11H2,1-5H3,(H,27,30)(H2,23,24,25,26,32)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168338
PNG
(US9669031, 187 8-chloro-6-[(5-methoxypyrimidin-4-y...)
Show SMILES COc1cncnc1Nc1cc(Cl)c2C(=O)NC3(CCCCC3)n2c1=O
Show InChI InChI=1S/C17H18ClN5O3/c1-26-12-8-19-9-20-14(12)21-11-7-10(18)13-15(24)22-17(23(13)16(11)25)5-3-2-4-6-17/h7-9H,2-6H2,1H3,(H,22,24)(H,19,20,21)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168208
PNG
(US9669031, 39 8′-chloro-6′-(pyrimidin-...)
Show SMILES Clc1cc(Nc2ccncn2)c(=O)n2c1C(=O)NC21CCCC1
Show InChI InChI=1S/C15H14ClN5O2/c16-9-7-10(19-11-3-6-17-8-18-11)14(23)21-12(9)13(22)20-15(21)4-1-2-5-15/h3,6-8H,1-2,4-5H2,(H,20,22)(H,17,18,19)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168211
PNG
(US9669031, 42 N-[6-[(8-chloro-3-cyclopentyl-3-meth...)
Show SMILES CC1(NC(=O)c2c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12)C1CCCC1
Show InChI InChI=1S/C21H23ClN6O3/c1-21(12-4-2-3-5-12)27-19(30)17-13(22)8-14(20(31)28(17)21)25-15-9-16(24-10-23-15)26-18(29)11-6-7-11/h8-12H,2-7H2,1H3,(H,27,30)(H2,23,24,25,26,29)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168212
PNG
(US9669031, 43 N-[6-[(8-chloro-3,3-dimethyl-1,5-dio...)
Show SMILES CC1(C)NC(=O)c2c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12
Show InChI InChI=1S/C17H17ClN6O3/c1-17(2)23-15(26)13-9(18)5-10(16(27)24(13)17)21-11-6-12(20-7-19-11)22-14(25)8-3-4-8/h5-8H,3-4H2,1-2H3,(H,23,26)(H2,19,20,21,22,25)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168213
PNG
(US9669031, 44 N-(6-((8′-chloro-1′,5...)
Show SMILES Clc1cc(Nc2cc(NC(=O)C3CC3)ncn2)c(=O)n2c1C(=O)NC21CCC1
Show InChI InChI=1S/C18H17ClN6O3/c19-10-6-11(17(28)25-14(10)16(27)24-18(25)4-1-5-18)22-12-7-13(21-8-20-12)23-15(26)9-2-3-9/h6-9H,1-5H2,(H,24,27)(H2,20,21,22,23,26)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168214
PNG
(US9669031, 207 6′-((6-aminopyrimidin-4-yl)am...)
Show SMILES Clc1cc(Nc2cc(NC(=O)C3CC3)ncn2)c(=O)n2c1C(=O)NC21CCCCC1
Show InChI InChI=1S/C20H21ClN6O3/c21-12-8-13(24-14-9-15(23-10-22-14)25-17(28)11-4-5-11)19(30)27-16(12)18(29)26-20(27)6-2-1-3-7-20/h8-11H,1-7H2,(H,26,29)(H2,22,23,24,25,28)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168215
PNG
(US9669031, 46 N-[6-[[8-chloro-3-methyl-1,5-dioxo-3...)
Show SMILES CC1(CC(F)(F)F)NC(=O)c2c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12
Show InChI InChI=1S/C18H16ClF3N6O3/c1-17(6-18(20,21)22)27-15(30)13-9(19)4-10(16(31)28(13)17)25-11-5-12(24-7-23-11)26-14(29)8-2-3-8/h4-5,7-8H,2-3,6H2,1H3,(H,27,30)(H2,23,24,25,26,29)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168216
PNG
(US9669031, 181 3,3-dimethyl-1,5-dioxo-6-(pyrimidin...)
Show SMILES CC1(C)NC(=O)c2c(Cl)cc(Nc3ccncn3)c(=O)n12
Show InChI InChI=1S/C13H12ClN5O2/c1-13(2)18-11(20)10-7(14)5-8(12(21)19(10)13)17-9-3-4-15-6-16-9/h3-6H,1-2H3,(H,18,20)(H,15,16,17)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168217
PNG
(US9669031, 48 8-chloro-3-cyclopentyl-3-methyl-6-(p...)
Show SMILES CC1(NC(=O)c2c(Cl)cc(Nc3ccncn3)c(=O)n12)C1CCCC1
Show InChI InChI=1S/C17H18ClN5O2/c1-17(10-4-2-3-5-10)22-15(24)14-11(18)8-12(16(25)23(14)17)21-13-6-7-19-9-20-13/h6-10H,2-5H2,1H3,(H,22,24)(H,19,20,21)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168220
PNG
(US9669031, 49 N-(6-((8-chloro-3-methyl-1,5-dioxo-3...)
Show SMILES CC1(NC(=O)c2c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12)C(F)(F)F
Show InChI InChI=1S/C17H14ClF3N6O3/c1-16(17(19,20)21)26-14(29)12-8(18)4-9(15(30)27(12)16)24-10-5-11(23-6-22-10)25-13(28)7-2-3-7/h4-7H,2-3H2,1H3,(H,26,29)(H2,22,23,24,25,28)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168221
PNG
(US9669031, 50 N-[6-[(8-chloro-4′,4′-di...)
Show SMILES FC1(F)CCC2(CC1)NC(=O)c1c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n21
Show InChI InChI=1S/C20H19ClF2N6O3/c21-11-7-12(26-13-8-14(25-9-24-13)27-16(30)10-1-2-10)18(32)29-15(11)17(31)28-20(29)5-3-19(22,23)4-6-20/h7-10H,1-6H2,(H,28,31)(H2,24,25,26,27,30)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168222
PNG
(US9669031, 51 N-[6-[[8-chloro-3-(3-chlorophenyl)-3...)
Show SMILES CC1(NC(=O)c2c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12)c1cccc(Cl)c1
Show InChI InChI=1S/C22H18Cl2N6O3/c1-22(12-3-2-4-13(23)7-12)29-20(32)18-14(24)8-15(21(33)30(18)22)27-16-9-17(26-10-25-16)28-19(31)11-5-6-11/h2-4,7-11H,5-6H2,1H3,(H,29,32)(H2,25,26,27,28,31)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168223
PNG
(US9669031, 52 N-[6-[[8-chloro-3-(3-fluorophenyl)-3...)
Show SMILES CC1(NC(=O)c2c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12)c1cccc(F)c1
Show InChI InChI=1S/C22H18ClFN6O3/c1-22(12-3-2-4-13(24)7-12)29-20(32)18-14(23)8-15(21(33)30(18)22)27-16-9-17(26-10-25-16)28-19(31)11-5-6-11/h2-4,7-11H,5-6H2,1H3,(H,29,32)(H2,25,26,27,28,31)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168226
PNG
(US9669031, 55 8-chloro-3-methyl-6-(pyrimidin-4-yla...)
Show SMILES CC1(CC(F)(F)F)NC(=O)c2c(Cl)cc(Nc3ccncn3)c(=O)n12
Show InChI InChI=1S/C14H11ClF3N5O2/c1-13(5-14(16,17)18)22-11(24)10-7(15)4-8(12(25)23(10)13)21-9-2-3-19-6-20-9/h2-4,6H,5H2,1H3,(H,22,24)(H,19,20,21)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168228
PNG
(US9669031, 56 N-(6-((8-chloro-1,5-dioxo-1,5-dihydr...)
Show SMILES CC(C)(C)OC(=O)N1CCC2(CC1)NC(=O)c1c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n21
Show InChI InChI=1S/C24H28ClN7O5/c1-23(2,3)37-22(36)31-8-6-24(7-9-31)30-20(34)18-14(25)10-15(21(35)32(18)24)28-16-11-17(27-12-26-16)29-19(33)13-4-5-13/h10-13H,4-9H2,1-3H3,(H,30,34)(H2,26,27,28,29,33)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168229
PNG
(US9669031, 57 8-chloro-3-(3-fluorophenyl)-3-methyl...)
Show SMILES CC1(NC(=O)c2c(Cl)cc(Nc3ccncn3)c(=O)n12)c1cccc(F)c1
Show InChI InChI=1S/C18H13ClFN5O2/c1-18(10-3-2-4-11(20)7-10)24-16(26)15-12(19)8-13(17(27)25(15)18)23-14-5-6-21-9-22-14/h2-9H,1H3,(H,24,26)(H,21,22,23)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168230
PNG
(US9669031, 58 8-chloro-3-(3-chlorophenyl)-3-methyl...)
Show SMILES CC1(NC(=O)c2c(Cl)cc(Nc3ccncn3)c(=O)n12)c1cccc(Cl)c1
Show InChI InChI=1S/C18H13Cl2N5O2/c1-18(10-3-2-4-11(19)7-10)24-16(26)15-12(20)8-13(17(27)25(15)18)23-14-5-6-21-9-22-14/h2-9H,1H3,(H,24,26)(H,21,22,23)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168232
PNG
(US9669031, 60 N-(6-((8-chloro-1,5-dioxo-1,5-dihydr...)
Show SMILES CC(C)(C)OC(=O)N1CCCC2(C1)NC(=O)c1c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n21
Show InChI InChI=1S/C24H28ClN7O5/c1-23(2,3)37-22(36)31-8-4-7-24(11-31)30-20(34)18-14(25)9-15(21(35)32(18)24)28-16-10-17(27-12-26-16)29-19(33)13-5-6-13/h9-10,12-13H,4-8,11H2,1-3H3,(H,30,34)(H2,26,27,28,29,33)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168233
PNG
(US9669031, 61 N-(6-((8-chloro-1,5-dioxo-1,2′...)
Show SMILES Clc1cc(Nc2cc(NC(=O)C3CC3)ncn2)c(=O)n2c1C(=O)NC21CCOCC1
Show InChI InChI=1S/C19H19ClN6O4/c20-11-7-12(23-13-8-14(22-9-21-13)24-16(27)10-1-2-10)18(29)26-15(11)17(28)25-19(26)3-5-30-6-4-19/h7-10H,1-6H2,(H,25,28)(H2,21,22,23,24,27)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168234
PNG
(US9669031, 62 N-[6-[(8-chloro-1′,1′-di...)
Show SMILES FC1(F)CC2(C1)NC(=O)c1c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n21
Show InChI InChI=1S/C18H15ClF2N6O3/c19-9-3-10(24-11-4-12(23-7-22-11)25-14(28)8-1-2-8)16(30)27-13(9)15(29)26-18(27)5-17(20,21)6-18/h3-4,7-8H,1-2,5-6H2,(H,26,29)(H2,22,23,24,25,28)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168235
PNG
(US9669031, 63 8-chloro-2′,2′-dimethyl-...)
Show SMILES CC1(C)CCCC11NC(=O)c2c(Cl)cc(Nc3ccncn3)c(=O)n12
Show InChI InChI=1S/C17H18ClN5O2/c1-16(2)5-3-6-17(16)22-14(24)13-10(18)8-11(15(25)23(13)17)21-12-4-7-19-9-20-12/h4,7-9H,3,5-6H2,1-2H3,(H,22,24)(H,19,20,21)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168237
PNG
(US9669031, 65 N-(6-((8-chloro-1,5-dioxo-1,5-dihydr...)
Show SMILES Clc1cc(Nc2cc(NC(=O)C3CC3)ncn2)c(=O)n2c1C(=O)NC21CSC1
Show InChI InChI=1S/C17H15ClN6O3S/c18-9-3-10(16(27)24-13(9)15(26)23-17(24)5-28-6-17)21-11-4-12(20-7-19-11)22-14(25)8-1-2-8/h3-4,7-8H,1-2,5-6H2,(H,23,26)(H2,19,20,21,22,25)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168238
PNG
(US9669031, 66 8-chloro-2′-fluoro-6-(pyrimidi...)
Show SMILES FC1CCCCC11NC(=O)c2c(Cl)cc(Nc3ccncn3)c(=O)n12
Show InChI InChI=1S/C16H15ClFN5O2/c17-9-7-10(21-12-4-6-19-8-20-12)15(25)23-13(9)14(24)22-16(23)5-2-1-3-11(16)18/h4,6-8,11H,1-3,5H2,(H,22,24)(H,19,20,21)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168241
PNG
(US9669031, 69 8-fluoro-3,3-dimethyl-6-(pyrimidin-4...)
Show SMILES CC1(C)NC(=O)c2c(F)cc(Nc3ccncn3)c(=O)n12
Show InChI InChI=1S/C13H12FN5O2/c1-13(2)18-11(20)10-7(14)5-8(12(21)19(10)13)17-9-3-4-15-6-16-9/h3-6H,1-2H3,(H,18,20)(H,15,16,17)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168242
PNG
(US9669031, 70 6′-((6-aminopyrimidin-4-yl)ami...)
Show SMILES Nc1cc(Nc2cc(Cl)c3C(=O)NC4(CCOCC4)n3c2=O)ncn1
Show InChI InChI=1S/C15H15ClN6O3/c16-8-5-9(20-11-6-10(17)18-7-19-11)14(24)22-12(8)13(23)21-15(22)1-3-25-4-2-15/h5-7H,1-4H2,(H,21,23)(H3,17,18,19,20)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM168244
PNG
(US9669031, 72 8-chloro-3-methyl-3-(3-pyridyl)-6-(p...)
Show SMILES CC1(NC(=O)c2c(Cl)cc(Nc3ccncn3)c(=O)n12)c1cccnc1
Show InChI InChI=1S/C17H13ClN6O2/c1-17(10-3-2-5-19-8-10)23-15(25)14-11(18)7-12(16(26)24(14)17)22-13-4-6-20-9-21-13/h2-9H,1H3,(H,23,25)(H,20,21,22)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US9669031 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
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