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Compile Data Set for Download or QSAR

Found 144 hits Enz. Inhib. hit(s) with Target = 'MLL'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Myeloid/lymphoid or mixed-lineage leukemia (MLL)


(Homo sapiens (Human))
BDBM200723
PNG
(US9233086, 10L)
Show SMILES CCC(CC)(NC(=O)C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NC1(CCCC1)C(=O)NC(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1/C35H49F2N7O4/c1-5-34(6-2,43-29(45)22(3)4)31(47)41-27(10-9-21-40-33(38)39)30(46)44-35(19-7-8-20-35)32(48)42-28(23-11-15-25(36)16-12-23)24-13-17-26(37)18-14-24/h11-18,22,27-28H,5-10,19-21H2,1-4H3,(H,41,47)(H,42,48)(H,43,45)(H,44,46)(H4,38,39,40)/t27-/s2
PDB

UniProtKB/SwissProt

GoogleScholar
Purchase

PC cid
PC sid
UniChem
PubMed
n/an/a 2.40n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of MLL1 binding to N-terminal His-tagged WRD5 23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli Roset...


Bioorg Med Chem 26: 356-365 (2018)

More data for this
Ligand-Target Pair
Myeloid/lymphoid or mixed-lineage leukemia (MLL)


(Homo sapiens (Human))
BDBM200712
PNG
(US9233086, 10A)
Show SMILES CCC(CC)(NC(=O)C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NC1(CCCC1)C(=O)NC(c1ccccc1)c1ccccc1
Show InChI InChI=1/C35H51N7O4/c1-5-34(6-2,41-29(43)24(3)4)31(45)39-27(20-15-23-38-33(36)37)30(44)42-35(21-13-14-22-35)32(46)40-28(25-16-9-7-10-17-25)26-18-11-8-12-19-26/h7-12,16-19,24,27-28H,5-6,13-15,20-23H2,1-4H3,(H,39,45)(H,40,46)(H,41,43)(H,42,44)(H4,36,37,38)/t27-/s2
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 2.90n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of MLL1 binding to N-terminal His-tagged WRD5 23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli Roset...


Bioorg Med Chem 26: 356-365 (2018)

More data for this
Ligand-Target Pair
Myeloid/lymphoid or mixed-lineage leukemia (MLL)


(Homo sapiens (Human))
BDBM200722
PNG
(US9233086, 10K)
Show SMILES CCC(CC)(NC(=O)C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NC1(CCCC1)C(=O)NC(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1/C35H49Cl2N7O4/c1-5-34(6-2,43-29(45)22(3)4)31(47)41-27(10-9-21-40-33(38)39)30(46)44-35(19-7-8-20-35)32(48)42-28(23-11-15-25(36)16-12-23)24-13-17-26(37)18-14-24/h11-18,22,27-28H,5-10,19-21H2,1-4H3,(H,41,47)(H,42,48)(H,43,45)(H,44,46)(H4,38,39,40)/t27-/s2
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 4.5n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of MLL1 binding to N-terminal His-tagged WRD5 23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli Roset...


Bioorg Med Chem 26: 356-365 (2018)

More data for this
Ligand-Target Pair
Protein AF-9


(Homo sapiens)
BDBM50459727
PNG
(CHEMBL4206834)
Show SMILES CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)c1ccccc1)C(=O)N[C@@H](CN)C(=O)N[C@@H](CC1CCCC1)C(=O)N1CCC[C@H]1c1nc(cn1CC1CCCCC1)-c1ccccc1
Show InChI InChI=1S/C48H66N8O5/c1-32(2)42(53-45(58)41-25-15-27-56(41)47(60)36-22-10-5-11-23-36)46(59)52-38(29-49)44(57)51-37(28-33-16-12-13-17-33)48(61)55-26-14-24-40(55)43-50-39(35-20-8-4-9-21-35)31-54(43)30-34-18-6-3-7-19-34/h4-5,8-11,20-23,31-34,37-38,40-42H,3,6-7,12-19,24-30,49H2,1-2H3,(H,51,57)(H,52,59)(H,53,58)/t37-,38-,40-,41-,42-/m0/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
UniChem
PubMed
n/an/a 57n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Displacement of N-Flu-DOT1L from MBP-tagged AF9 (unknown origin) (487 to 568 residues) expressed in Escherichia coli BL21(DE3) measured after 3 hrs b...


ACS Med Chem Lett 9: 895-900 (2018)

More data for this
Ligand-Target Pair
Protein AF-9


(Homo sapiens)
BDBM50459737
PNG
(CHEMBL4211204)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CN)C(=O)N[C@@H](CC1CCCC1)C(=O)N1CCC[C@H]1c1nc(cn1CC1CCCCC1)-c1ccccc1
Show InChI InChI=1S/C49H75N9O6/c1-31(2)26-37(51-33(5)59)48(63)58-25-15-23-42(58)46(61)55-43(32(3)4)47(62)54-39(28-50)45(60)53-38(27-34-16-12-13-17-34)49(64)57-24-14-22-41(57)44-52-40(36-20-10-7-11-21-36)30-56(44)29-35-18-8-6-9-19-35/h7,10-11,20-21,30-32,34-35,37-39,41-43H,6,8-9,12-19,22-29,50H2,1-5H3,(H,51,59)(H,53,60)(H,54,62)(H,55,61)/t37-,38-,39-,41-,42-,43-/m0/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
UniChem
PubMed
n/an/a 82n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Displacement of N-Flu-DOT1L from MBP-tagged AF9 (unknown origin) (487 to 568 residues) expressed in Escherichia coli BL21(DE3) measured after 3 hrs b...


ACS Med Chem Lett 9: 895-900 (2018)

More data for this
Ligand-Target Pair
Protein AF-9


(Homo sapiens)
BDBM50459731
PNG
(CHEMBL4216416)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(C)=O)C(=O)N[C@@H](CN)C(=O)N[C@@H](CC1CCCC1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N(C)C
Show InChI InChI=1S/C43H75N9O8/c1-10-27(6)36(49-39(56)35-18-14-20-52(35)42(59)31(22-26(4)5)45-28(7)53)40(57)48-33(24-44)37(54)46-32(23-29-15-11-12-16-29)43(60)51-19-13-17-34(51)38(55)47-30(21-25(2)3)41(58)50(8)9/h25-27,29-36H,10-24,44H2,1-9H3,(H,45,53)(H,46,54)(H,47,55)(H,48,57)(H,49,56)/t27-,30-,31-,32-,33-,34-,35-,36-/m0/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
UniChem
PubMed
n/an/a 120n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Displacement of N-Flu-DOT1L from MBP-tagged AF9 (unknown origin) (487 to 568 residues) expressed in Escherichia coli BL21(DE3) measured after 3 hrs b...


ACS Med Chem Lett 9: 895-900 (2018)

More data for this
Ligand-Target Pair
Protein AF-9


(Homo sapiens)
BDBM50459738
PNG
(CHEMBL4209820)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(C)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(N)=O
Show InChI InChI=1S/C51H89N11O14/c1-13-28(9)39(58-47(72)37-18-15-19-61(37)50(75)33(22-26(5)6)53-31(12)66)48(73)56-35(24-64)44(69)59-40(29(10)14-2)51(76)62-20-16-17-36(62)46(71)54-32(21-25(3)4)43(68)55-34(23-63)45(70)60-41(30(11)65)49(74)57-38(27(7)8)42(52)67/h25-30,32-41,63-65H,13-24H2,1-12H3,(H2,52,67)(H,53,66)(H,54,71)(H,55,68)(H,56,73)(H,57,74)(H,58,72)(H,59,69)(H,60,70)/t28-,29-,30+,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-/m0/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
UniChem
PubMed
n/an/a 140n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Displacement of N-Flu-DOT1L from MBP-tagged AF9 (unknown origin) (487 to 568 residues) expressed in Escherichia coli BL21(DE3) measured after 3 hrs b...


ACS Med Chem Lett 9: 895-900 (2018)

More data for this
Ligand-Target Pair
Protein AF-9


(Homo sapiens)
BDBM50459730
PNG
(CHEMBL4211714)
Show SMILES CC(C)CCC(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CN)C(=O)N[C@@H](CC1CCCC1)C(=O)N1CCC[C@H]1c1nc(cn1CC1CCCCC1)-c1ccccc1
Show InChI InChI=1S/C47H72N8O5/c1-31(2)23-24-41(56)54-25-14-22-40(54)45(58)52-42(32(3)4)46(59)51-37(28-48)44(57)50-36(27-33-15-11-12-16-33)47(60)55-26-13-21-39(55)43-49-38(35-19-9-6-10-20-35)30-53(43)29-34-17-7-5-8-18-34/h6,9-10,19-20,30-34,36-37,39-40,42H,5,7-8,11-18,21-29,48H2,1-4H3,(H,50,57)(H,51,59)(H,52,58)/t36-,37-,39-,40-,42-/m0/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
UniChem
PubMed
n/an/a 149n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Displacement of N-Flu-DOT1L from MBP-tagged AF9 (unknown origin) (487 to 568 residues) expressed in Escherichia coli BL21(DE3) measured after 3 hrs b...


ACS Med Chem Lett 9: 895-900 (2018)

More data for this
Ligand-Target Pair
MLL


(Homo sapiens (Human))
BDBM50208354
PNG
(CHEMBL3884329)
Show SMILES CN1CCN(CC1)c1ccc(cc1NC(=O)c1cc(N)c(F)c(C)c1Cl)-c1ccc(NC(=O)CCCN)cc1
Show InChI InChI=1S/C29H34ClFN6O2/c1-18-27(30)22(17-23(33)28(18)31)29(39)35-24-16-20(7-10-25(24)37-14-12-36(2)13-15-37)19-5-8-21(9-6-19)34-26(38)4-3-11-32/h5-10,16-17H,3-4,11-15,32-33H2,1-2H3,(H,34,38)(H,35,39)
PDB

KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 190n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant MLL1/ASH2L/RBBP5/WDR5 complex histone methyltransferase activity (unknown origin) by AlphaScreen assay


Eur J Med Chem 124: 480-489 (2016)


Article DOI: 10.1016/j.ejmech.2016.08.036
BindingDB Entry DOI: 10.7270/Q2251M6G
More data for this
Ligand-Target Pair
Protein ENL


(Homo sapiens)
BDBM50459730
PNG
(CHEMBL4211714)
Show SMILES CC(C)CCC(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CN)C(=O)N[C@@H](CC1CCCC1)C(=O)N1CCC[C@H]1c1nc(cn1CC1CCCCC1)-c1ccccc1
Show InChI InChI=1S/C47H72N8O5/c1-31(2)23-24-41(56)54-25-14-22-40(54)45(58)52-42(32(3)4)46(59)51-37(28-48)44(57)50-36(27-33-15-11-12-16-33)47(60)55-26-13-21-39(55)43-49-38(35-19-9-6-10-20-35)30-53(43)29-34-17-7-5-8-18-34/h6,9-10,19-20,30-34,36-37,39-40,42H,5,7-8,11-18,21-29,48H2,1-4H3,(H,50,57)(H,51,59)(H,52,58)/t36-,37-,39-,40-,42-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
PubMed
n/an/a 237n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Displacement of N-Flu-DOT1L from MBP-tagged ENL (unknown origin) (489 to 559 residues) expressed in Escherichia coli BL21(DE3) measured after 3 hrs b...


ACS Med Chem Lett 9: 895-900 (2018)

More data for this
Ligand-Target Pair
MLL


(Homo sapiens (Human))
BDBM50164787
PNG
(CHEMBL3798088)
Show SMILES CC[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@](C)(CCCCNC(=O)[C@H](NC1=O)c1ccccc1)NC(=O)C(C)C
Show InChI InChI=1/C29H46N8O5/c1-5-20-24(39)36-22(19-12-7-6-8-13-19)26(41)32-16-10-9-15-29(4,37-23(38)18(2)3)27(42)35-21(25(40)34-20)14-11-17-33-28(30)31/h6-8,12-13,18,20-22H,5,9-11,14-17H2,1-4H3,(H,32,41)(H,34,40)(H,35,42)(H,36,39)(H,37,38)(H4,30,31,33)/t20-,21-,22+,29+/s2
PDB

KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 300n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant SUMO-fused MLL1/ASH2L/RBBP5/WDR5 complex histone methyltransferase activity (unknown origin) expressed in Escherichia coli ...


Eur J Med Chem 124: 480-489 (2016)


Article DOI: 10.1016/j.ejmech.2016.08.036
BindingDB Entry DOI: 10.7270/Q2251M6G
More data for this
Ligand-Target Pair
MLL


(Homo sapiens (Human))
BDBM50208353
PNG
(CHEMBL3884726)
Show SMILES CN1CCN(CC1)c1ccc(cc1NC(=O)c1cc(N)c(F)c(C)c1Cl)-c1ccc(NC(=O)C2CCNCC2)cc1
Show InChI InChI=1S/C31H36ClFN6O2/c1-19-28(32)24(18-25(34)29(19)33)31(41)37-26-17-22(5-8-27(26)39-15-13-38(2)14-16-39)20-3-6-23(7-4-20)36-30(40)21-9-11-35-12-10-21/h3-8,17-18,21,35H,9-16,34H2,1-2H3,(H,36,40)(H,37,41)
PDB

KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 300n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant MLL1/ASH2L/RBBP5/WDR5 complex histone methyltransferase activity (unknown origin) by AlphaScreen assay


Eur J Med Chem 124: 480-489 (2016)


Article DOI: 10.1016/j.ejmech.2016.08.036
BindingDB Entry DOI: 10.7270/Q2251M6G
More data for this
Ligand-Target Pair
MLL


(Homo sapiens (Human))
BDBM50164787
PNG
(CHEMBL3798088)
Show SMILES CC[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@](C)(CCCCNC(=O)[C@H](NC1=O)c1ccccc1)NC(=O)C(C)C
Show InChI InChI=1/C29H46N8O5/c1-5-20-24(39)36-22(19-12-7-6-8-13-19)26(41)32-16-10-9-15-29(4,37-23(38)18(2)3)27(42)35-21(25(40)34-20)14-11-17-33-28(30)31/h6-8,12-13,18,20-22H,5,9-11,14-17H2,1-4H3,(H,32,41)(H,34,40)(H,35,42)(H,36,39)(H,37,38)(H4,30,31,33)/t20-,21-,22+,29+/s2
PDB

KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 300n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of His-SUMO-fused MLL1 (3762 to 3969 residues) interaction with His-SUMO-fused ASH2L/RBBP5/WDR5 (23 to 334 residues) (unknown origin) expr...


Bioorg Med Chem 24: 6109-6118 (2016)


Article DOI: 10.1016/j.bmc.2016.09.073
BindingDB Entry DOI: 10.7270/Q2F47R4K
More data for this
Ligand-Target Pair
Myeloid/lymphoid or mixed-lineage leukemia (MLL)


(Homo sapiens (Human))
BDBM50164787
PNG
(CHEMBL3798088)
Show SMILES CC[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@](C)(CCCCNC(=O)[C@H](NC1=O)c1ccccc1)NC(=O)C(C)C
Show InChI InChI=1/C29H46N8O5/c1-5-20-24(39)36-22(19-12-7-6-8-13-19)26(41)32-16-10-9-15-29(4,37-23(38)18(2)3)27(42)35-21(25(40)34-20)14-11-17-33-28(30)31/h6-8,12-13,18,20-22H,5,9-11,14-17H2,1-4H3,(H,32,41)(H,34,40)(H,35,42)(H,36,39)(H,37,38)(H4,30,31,33)/t20-,21-,22+,29+/s2
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

PubMed
n/an/a 320n/an/an/an/an/an/a



University of Connecticut

Curated by ChEMBL


Assay Description
Inhibition of recombinant SUMO-tagged MLL1 (unknown origin) by histone methyl transferase assay


Eur J Med Chem 136: 14-35 (2017)

More data for this
Ligand-Target Pair
Myeloid/lymphoid or mixed-lineage leukemia (MLL)


(Homo sapiens (Human))
BDBM50164787
PNG
(CHEMBL3798088)
Show SMILES CC[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@](C)(CCCCNC(=O)[C@H](NC1=O)c1ccccc1)NC(=O)C(C)C
Show InChI InChI=1/C29H46N8O5/c1-5-20-24(39)36-22(19-12-7-6-8-13-19)26(41)32-16-10-9-15-29(4,37-23(38)18(2)3)27(42)35-21(25(40)34-20)14-11-17-33-28(30)31/h6-8,12-13,18,20-22H,5,9-11,14-17H2,1-4H3,(H,32,41)(H,34,40)(H,35,42)(H,36,39)(H,37,38)(H4,30,31,33)/t20-,21-,22+,29+/s2
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 320n/an/an/an/an/an/a



Ontario Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of SUMO-His-tagged MLL1 activity (unknown origin) expressed in Escherichia coli BL21(DE3) pLysS cells using histone H3 as substrate by sci...


J Med Chem 59: 2478-96 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01630
BindingDB Entry DOI: 10.7270/Q2VT1V0C
More data for this
Ligand-Target Pair
Protein AF-9


(Homo sapiens)
BDBM50459747
PNG
(CHEMBL4216933)
Show SMILES CCn1cc(nc1[C@@H]1CCCN1C(=O)[C@H](CC1CCCC1)NC(=O)[C@H](CN)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(C)=O)C(C)C)-c1ccccc1
Show InChI InChI=1S/C44H67N9O6/c1-7-51-26-35(31-17-9-8-10-18-31)47-39(51)36-19-13-21-52(36)44(59)33(24-30-15-11-12-16-30)48-40(55)34(25-45)49-42(57)38(28(4)5)50-41(56)37-20-14-22-53(37)43(58)32(23-27(2)3)46-29(6)54/h8-10,17-18,26-28,30,32-34,36-38H,7,11-16,19-25,45H2,1-6H3,(H,46,54)(H,48,55)(H,49,57)(H,50,56)/t32-,33-,34-,36-,37-,38-/m0/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
UniChem
PubMed
n/an/a 341n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Displacement of N-Flu-DOT1L from MBP-tagged AF9 (unknown origin) (487 to 568 residues) expressed in Escherichia coli BL21(DE3) measured after 3 hrs b...


ACS Med Chem Lett 9: 895-900 (2018)

More data for this
Ligand-Target Pair
Protein AF-9


(Homo sapiens)
BDBM50459735
PNG
(CHEMBL4216170)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CN)C(=O)N[C@@H](CC1CCCC1)C(=O)N1CCC[C@H]1c1nc(cn1C(C)C)-c1ccccc1
Show InChI InChI=1S/C45H69N9O6/c1-27(2)23-33(47-30(7)55)44(59)53-22-14-20-38(53)42(57)51-39(28(3)4)43(58)50-35(25-46)41(56)49-34(24-31-15-11-12-16-31)45(60)52-21-13-19-37(52)40-48-36(26-54(40)29(5)6)32-17-9-8-10-18-32/h8-10,17-18,26-29,31,33-35,37-39H,11-16,19-25,46H2,1-7H3,(H,47,55)(H,49,56)(H,50,58)(H,51,57)/t33-,34-,35-,37-,38-,39-/m0/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
UniChem
PubMed
n/an/a 369n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Displacement of N-Flu-DOT1L from MBP-tagged AF9 (unknown origin) (487 to 568 residues) expressed in Escherichia coli BL21(DE3) measured after 3 hrs b...


ACS Med Chem Lett 9: 895-900 (2018)

More data for this
Ligand-Target Pair
Protein AF-9


(Homo sapiens)
BDBM50459726
PNG
(CHEMBL4211962)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CN)C(=O)N[C@@H](CC1CCCC1)C(=O)N1CCC[C@H]1c1nc(cn1C)-c1ccccc1
Show InChI InChI=1S/C43H65N9O6/c1-26(2)22-31(45-28(5)53)42(57)52-21-13-19-36(52)40(55)49-37(27(3)4)41(56)48-33(24-44)39(54)47-32(23-29-14-10-11-15-29)43(58)51-20-12-18-35(51)38-46-34(25-50(38)6)30-16-8-7-9-17-30/h7-9,16-17,25-27,29,31-33,35-37H,10-15,18-24,44H2,1-6H3,(H,45,53)(H,47,54)(H,48,56)(H,49,55)/t31-,32-,33-,35-,36-,37-/m0/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
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PubMed
n/an/a 372n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Displacement of N-Flu-DOT1L from MBP-tagged AF9 (unknown origin) (487 to 568 residues) expressed in Escherichia coli BL21(DE3) measured after 3 hrs b...


ACS Med Chem Lett 9: 895-900 (2018)

More data for this
Ligand-Target Pair
Protein ENL


(Homo sapiens)
BDBM50459731
PNG
(CHEMBL4216416)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(C)=O)C(=O)N[C@@H](CN)C(=O)N[C@@H](CC1CCCC1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N(C)C
Show InChI InChI=1S/C43H75N9O8/c1-10-27(6)36(49-39(56)35-18-14-20-52(35)42(59)31(22-26(4)5)45-28(7)53)40(57)48-33(24-44)37(54)46-32(23-29-15-11-12-16-29)43(60)51-19-13-17-34(51)38(55)47-30(21-25(2)3)41(58)50(8)9/h25-27,29-36H,10-24,44H2,1-9H3,(H,45,53)(H,46,54)(H,47,55)(H,48,57)(H,49,56)/t27-,30-,31-,32-,33-,34-,35-,36-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
PubMed
n/an/a 390n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Displacement of N-Flu-DOT1L from MBP-tagged ENL (unknown origin) (489 to 559 residues) expressed in Escherichia coli BL21(DE3) measured after 3 hrs b...


ACS Med Chem Lett 9: 895-900 (2018)

More data for this
Ligand-Target Pair
MLL


(Homo sapiens (Human))
BDBM200723
PNG
(US9233086, 10L)
Show SMILES CCC(CC)(NC(=O)C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NC1(CCCC1)C(=O)NC(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1/C35H49F2N7O4/c1-5-34(6-2,43-29(45)22(3)4)31(47)41-27(10-9-21-40-33(38)39)30(46)44-35(19-7-8-20-35)32(48)42-28(23-11-15-25(36)16-12-23)24-13-17-26(37)18-14-24/h11-18,22,27-28H,5-10,19-21H2,1-4H3,(H,41,47)(H,42,48)(H,43,45)(H,44,46)(H4,38,39,40)/t27-/s2
PDB

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UniChem
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n/an/a 400n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant SUMO-fused MLL1/ASH2L/RBBP5/WDR5 complex histone methyltransferase activity (unknown origin) expressed in Escherichia coli ...


Eur J Med Chem 124: 480-489 (2016)


Article DOI: 10.1016/j.ejmech.2016.08.036
BindingDB Entry DOI: 10.7270/Q2251M6G
More data for this
Ligand-Target Pair
MLL


(Homo sapiens (Human))
BDBM200723
PNG
(US9233086, 10L)
Show SMILES CCC(CC)(NC(=O)C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NC1(CCCC1)C(=O)NC(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1/C35H49F2N7O4/c1-5-34(6-2,43-29(45)22(3)4)31(47)41-27(10-9-21-40-33(38)39)30(46)44-35(19-7-8-20-35)32(48)42-28(23-11-15-25(36)16-12-23)24-13-17-26(37)18-14-24/h11-18,22,27-28H,5-10,19-21H2,1-4H3,(H,41,47)(H,42,48)(H,43,45)(H,44,46)(H4,38,39,40)/t27-/s2
PDB

KEGG

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UniChem
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n/an/a 400n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of His-SUMO-fused MLL1 (3762 to 3969 residues) interaction with His-SUMO-fused ASH2L/RBBP5/WDR5 (23 to 334 residues) (unknown origin) expr...


Bioorg Med Chem 24: 6109-6118 (2016)


Article DOI: 10.1016/j.bmc.2016.09.073
BindingDB Entry DOI: 10.7270/Q2F47R4K
More data for this
Ligand-Target Pair
Protein ENL


(Homo sapiens)
BDBM50459737
PNG
(CHEMBL4211204)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CN)C(=O)N[C@@H](CC1CCCC1)C(=O)N1CCC[C@H]1c1nc(cn1CC1CCCCC1)-c1ccccc1
Show InChI InChI=1S/C49H75N9O6/c1-31(2)26-37(51-33(5)59)48(63)58-25-15-23-42(58)46(61)55-43(32(3)4)47(62)54-39(28-50)45(60)53-38(27-34-16-12-13-17-34)49(64)57-24-14-22-41(57)44-52-40(36-20-10-7-11-21-36)30-56(44)29-35-18-8-6-9-19-35/h7,10-11,20-21,30-32,34-35,37-39,41-43H,6,8-9,12-19,22-29,50H2,1-5H3,(H,51,59)(H,53,60)(H,54,62)(H,55,61)/t37-,38-,39-,41-,42-,43-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
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n/an/a 427n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Displacement of N-Flu-DOT1L from MBP-tagged ENL (unknown origin) (489 to 559 residues) expressed in Escherichia coli BL21(DE3) measured after 3 hrs b...


ACS Med Chem Lett 9: 895-900 (2018)

More data for this
Ligand-Target Pair
Protein ENL


(Homo sapiens)
BDBM50459727
PNG
(CHEMBL4206834)
Show SMILES CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)c1ccccc1)C(=O)N[C@@H](CN)C(=O)N[C@@H](CC1CCCC1)C(=O)N1CCC[C@H]1c1nc(cn1CC1CCCCC1)-c1ccccc1
Show InChI InChI=1S/C48H66N8O5/c1-32(2)42(53-45(58)41-25-15-27-56(41)47(60)36-22-10-5-11-23-36)46(59)52-38(29-49)44(57)51-37(28-33-16-12-13-17-33)48(61)55-26-14-24-40(55)43-50-39(35-20-8-4-9-21-35)31-54(43)30-34-18-6-3-7-19-34/h4-5,8-11,20-23,31-34,37-38,40-42H,3,6-7,12-19,24-30,49H2,1-2H3,(H,51,57)(H,52,59)(H,53,58)/t37-,38-,40-,41-,42-/m0/s1
PDB

UniProtKB/SwissProt

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n/an/a 504n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Displacement of N-Flu-DOT1L from MBP-tagged ENL (unknown origin) (489 to 559 residues) expressed in Escherichia coli BL21(DE3) measured after 3 hrs b...


ACS Med Chem Lett 9: 895-900 (2018)

More data for this
Ligand-Target Pair
Protein ENL


(Homo sapiens)
BDBM50459738
PNG
(CHEMBL4209820)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(C)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(N)=O
Show InChI InChI=1S/C51H89N11O14/c1-13-28(9)39(58-47(72)37-18-15-19-61(37)50(75)33(22-26(5)6)53-31(12)66)48(73)56-35(24-64)44(69)59-40(29(10)14-2)51(76)62-20-16-17-36(62)46(71)54-32(21-25(3)4)43(68)55-34(23-63)45(70)60-41(30(11)65)49(74)57-38(27(7)8)42(52)67/h25-30,32-41,63-65H,13-24H2,1-12H3,(H2,52,67)(H,53,66)(H,54,71)(H,55,68)(H,56,73)(H,57,74)(H,58,72)(H,59,69)(H,60,70)/t28-,29-,30+,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
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n/an/a 630n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Displacement of N-Flu-DOT1L from MBP-tagged ENL (unknown origin) (489 to 559 residues) expressed in Escherichia coli BL21(DE3) measured after 3 hrs b...


ACS Med Chem Lett 9: 895-900 (2018)

More data for this
Ligand-Target Pair
MLL


(Homo sapiens (Human))
BDBM200723
PNG
(US9233086, 10L)
Show SMILES CCC(CC)(NC(=O)C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NC1(CCCC1)C(=O)NC(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1/C35H49F2N7O4/c1-5-34(6-2,43-29(45)22(3)4)31(47)41-27(10-9-21-40-33(38)39)30(46)44-35(19-7-8-20-35)32(48)42-28(23-11-15-25(36)16-12-23)24-13-17-26(37)18-14-24/h11-18,22,27-28H,5-10,19-21H2,1-4H3,(H,41,47)(H,42,48)(H,43,45)(H,44,46)(H4,38,39,40)/t27-/s2
PDB

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UniChem
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n/an/a 750n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant MLL1/ASH2L/RBBP5/WDR5 complex histone methyltransferase activity (unknown origin) by AlphaScreen assay


Eur J Med Chem 124: 480-489 (2016)


Article DOI: 10.1016/j.ejmech.2016.08.036
BindingDB Entry DOI: 10.7270/Q2251M6G
More data for this
Ligand-Target Pair
Protein AF-9


(Homo sapiens)
BDBM50459733
PNG
(CHEMBL4209508)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(C)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1CCCC1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N(C)C
Show InChI InChI=1S/C43H74N8O9/c1-10-27(6)36(48-39(56)35-18-14-20-51(35)42(59)31(22-26(4)5)44-28(7)53)40(57)47-33(24-52)37(54)45-32(23-29-15-11-12-16-29)43(60)50-19-13-17-34(50)38(55)46-30(21-25(2)3)41(58)49(8)9/h25-27,29-36,52H,10-24H2,1-9H3,(H,44,53)(H,45,54)(H,46,55)(H,47,57)(H,48,56)/t27-,30-,31-,32-,33-,34-,35-,36-/m0/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
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PubMed
n/an/a 850n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Displacement of N-Flu-DOT1L from MBP-tagged AF9 (unknown origin) (487 to 568 residues) expressed in Escherichia coli BL21(DE3) measured after 3 hrs b...


ACS Med Chem Lett 9: 895-900 (2018)

More data for this
Ligand-Target Pair
MLL


(Homo sapiens (Human))
BDBM200723
PNG
(US9233086, 10L)
Show SMILES CCC(CC)(NC(=O)C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NC1(CCCC1)C(=O)NC(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1/C35H49F2N7O4/c1-5-34(6-2,43-29(45)22(3)4)31(47)41-27(10-9-21-40-33(38)39)30(46)44-35(19-7-8-20-35)32(48)42-28(23-11-15-25(36)16-12-23)24-13-17-26(37)18-14-24/h11-18,22,27-28H,5-10,19-21H2,1-4H3,(H,41,47)(H,42,48)(H,43,45)(H,44,46)(H4,38,39,40)/t27-/s2
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n/an/a 900n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant MLL1 (unknown origin) interaction with recombinant ASH2L/RBBP5/WDR5 (unknown origin) assessed as decrease in histone methyl...


Bioorg Med Chem 24: 6109-6118 (2016)


Article DOI: 10.1016/j.bmc.2016.09.073
BindingDB Entry DOI: 10.7270/Q2F47R4K
More data for this
Ligand-Target Pair
Protein AF-9


(Homo sapiens)
BDBM50459722
PNG
(CHEMBL4204545)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(C)=O)C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(N)=O
Show InChI InChI=1S/C38H66N8O9/c1-10-23(8)31(38(55)46-16-12-13-28(46)34(51)41-25(32(39)49)17-20(2)3)44-33(50)27(19-47)42-36(53)30(22(6)7)43-35(52)29-14-11-15-45(29)37(54)26(18-21(4)5)40-24(9)48/h20-23,25-31,47H,10-19H2,1-9H3,(H2,39,49)(H,40,48)(H,41,51)(H,42,53)(H,43,52)(H,44,50)/t23-,25-,26-,27-,28-,29-,30-,31-/m0/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

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n/an/a 1.02E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Displacement of N-Flu-DOT1L from MBP-tagged AF9 (unknown origin) (487 to 568 residues) expressed in Escherichia coli BL21(DE3) measured after 3 hrs b...


ACS Med Chem Lett 9: 895-900 (2018)

More data for this
Ligand-Target Pair
Protein AF-9


(Homo sapiens)
BDBM50459739
PNG
(CHEMBL4204942)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(C)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(N)=O
Show InChI InChI=1S/C39H68N8O9/c1-10-23(7)31(44-36(53)30-15-12-16-46(30)38(55)27(19-22(5)6)41-25(9)49)37(54)43-28(20-48)34(51)45-32(24(8)11-2)39(56)47-17-13-14-29(47)35(52)42-26(33(40)50)18-21(3)4/h21-24,26-32,48H,10-20H2,1-9H3,(H2,40,50)(H,41,49)(H,42,52)(H,43,54)(H,44,53)(H,45,51)/t23-,24-,26-,27-,28-,29-,30-,31-,32-/m0/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
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PubMed
n/an/a 1.04E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Displacement of N-Flu-DOT1L from MBP-tagged AF9 (unknown origin) (487 to 568 residues) expressed in Escherichia coli BL21(DE3) measured after 3 hrs b...


ACS Med Chem Lett 9: 895-900 (2018)

More data for this
Ligand-Target Pair
Protein AF-9


(Homo sapiens)
BDBM50459745
PNG
(CHEMBL4210431)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(C)=O)C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N(C)C
Show InChI InChI=1S/C40H70N8O9/c1-12-25(8)33(40(57)48-18-14-15-30(48)35(52)42-27(19-22(2)3)38(55)46(10)11)45-34(51)29(21-49)43-37(54)32(24(6)7)44-36(53)31-16-13-17-47(31)39(56)28(20-23(4)5)41-26(9)50/h22-25,27-33,49H,12-21H2,1-11H3,(H,41,50)(H,42,52)(H,43,54)(H,44,53)(H,45,51)/t25-,27-,28-,29-,30-,31-,32-,33-/m0/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
UniChem
PubMed
n/an/a 1.10E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Displacement of N-Flu-DOT1L from MBP-tagged AF9 (unknown origin) (487 to 568 residues) expressed in Escherichia coli BL21(DE3) measured after 3 hrs b...


ACS Med Chem Lett 9: 895-900 (2018)

More data for this
Ligand-Target Pair
Protein AF-9


(Homo sapiens)
BDBM50459742
PNG
(CHEMBL4204647)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(C)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1CCCCC1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N(C)C
Show InChI InChI=1S/C44H76N8O9/c1-10-28(6)37(49-40(57)36-19-15-21-52(36)43(60)32(23-27(4)5)45-29(7)54)41(58)48-34(25-53)38(55)46-33(24-30-16-12-11-13-17-30)44(61)51-20-14-18-35(51)39(56)47-31(22-26(2)3)42(59)50(8)9/h26-28,30-37,53H,10-25H2,1-9H3,(H,45,54)(H,46,55)(H,47,56)(H,48,58)(H,49,57)/t28-,31-,32-,33-,34-,35-,36-,37-/m0/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
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n/an/a 1.14E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Displacement of N-Flu-DOT1L from MBP-tagged AF9 (unknown origin) (487 to 568 residues) expressed in Escherichia coli BL21(DE3) measured after 3 hrs b...


ACS Med Chem Lett 9: 895-900 (2018)

More data for this
Ligand-Target Pair
Protein AF-9


(Homo sapiens)
BDBM50459743
PNG
(CHEMBL4209087)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(C)=O)C(=O)N[C@@H](CN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N(C)C
Show InChI InChI=1S/C41H73N9O8/c1-12-25(7)33(46-37(54)32-17-14-18-49(32)40(57)29(21-24(5)6)43-27(9)51)38(55)45-30(22-42)35(52)47-34(26(8)13-2)41(58)50-19-15-16-31(50)36(53)44-28(20-23(3)4)39(56)48(10)11/h23-26,28-34H,12-22,42H2,1-11H3,(H,43,51)(H,44,53)(H,45,55)(H,46,54)(H,47,52)/t25-,26-,28-,29-,30-,31-,32-,33-,34-/m0/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
UniChem
PubMed
n/an/a 1.20E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Displacement of N-Flu-DOT1L from MBP-tagged AF9 (unknown origin) (487 to 568 residues) expressed in Escherichia coli BL21(DE3) measured after 3 hrs b...


ACS Med Chem Lett 9: 895-900 (2018)

More data for this
Ligand-Target Pair
Protein ENL


(Homo sapiens)
BDBM50459735
PNG
(CHEMBL4216170)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CN)C(=O)N[C@@H](CC1CCCC1)C(=O)N1CCC[C@H]1c1nc(cn1C(C)C)-c1ccccc1
Show InChI InChI=1S/C45H69N9O6/c1-27(2)23-33(47-30(7)55)44(59)53-22-14-20-38(53)42(57)51-39(28(3)4)43(58)50-35(25-46)41(56)49-34(24-31-15-11-12-16-31)45(60)52-21-13-19-37(52)40-48-36(26-54(40)29(5)6)32-17-9-8-10-18-32/h8-10,17-18,26-29,31,33-35,37-39H,11-16,19-25,46H2,1-7H3,(H,47,55)(H,49,56)(H,50,58)(H,51,57)/t33-,34-,35-,37-,38-,39-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
PubMed
n/an/a 1.22E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Displacement of N-Flu-DOT1L from MBP-tagged ENL (unknown origin) (489 to 559 residues) expressed in Escherichia coli BL21(DE3) measured after 3 hrs b...


ACS Med Chem Lett 9: 895-900 (2018)

More data for this
Ligand-Target Pair
Protein AF-9


(Homo sapiens)
BDBM50459748
PNG
(CHEMBL4213382)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(C)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C1CCCC1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N(C)C
Show InChI InChI=1S/C42H72N8O9/c1-10-26(6)34(46-38(55)33-18-13-19-49(33)41(58)30(22-25(4)5)43-27(7)52)39(56)45-31(23-51)36(53)47-35(28-15-11-12-16-28)42(59)50-20-14-17-32(50)37(54)44-29(21-24(2)3)40(57)48(8)9/h24-26,28-35,51H,10-23H2,1-9H3,(H,43,52)(H,44,54)(H,45,56)(H,46,55)(H,47,53)/t26-,29-,30-,31-,32-,33-,34-,35-/m0/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
UniChem
PubMed
n/an/a 1.49E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Displacement of N-Flu-DOT1L from MBP-tagged AF9 (unknown origin) (487 to 568 residues) expressed in Escherichia coli BL21(DE3) measured after 3 hrs b...


ACS Med Chem Lett 9: 895-900 (2018)

More data for this
Ligand-Target Pair
Protein ENL


(Homo sapiens)
BDBM50459747
PNG
(CHEMBL4216933)
Show SMILES CCn1cc(nc1[C@@H]1CCCN1C(=O)[C@H](CC1CCCC1)NC(=O)[C@H](CN)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(C)=O)C(C)C)-c1ccccc1
Show InChI InChI=1S/C44H67N9O6/c1-7-51-26-35(31-17-9-8-10-18-31)47-39(51)36-19-13-21-52(36)44(59)33(24-30-15-11-12-16-30)48-40(55)34(25-45)49-42(57)38(28(4)5)50-41(56)37-20-14-22-53(37)43(58)32(23-27(2)3)46-29(6)54/h8-10,17-18,26-28,30,32-34,36-38H,7,11-16,19-25,45H2,1-6H3,(H,46,54)(H,48,55)(H,49,57)(H,50,56)/t32-,33-,34-,36-,37-,38-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
PubMed
n/an/a 1.57E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Displacement of N-Flu-DOT1L from MBP-tagged ENL (unknown origin) (489 to 559 residues) expressed in Escherichia coli BL21(DE3) measured after 3 hrs b...


ACS Med Chem Lett 9: 895-900 (2018)

More data for this
Ligand-Target Pair
MLL


(Homo sapiens (Human))
BDBM50208372
PNG
(CHEMBL3885241)
Show SMILES CN1CCN(CC1)c1ccc(cc1NC(=O)c1cc(N)c(F)c(C)c1Cl)-c1ccc(N)cc1
Show InChI InChI=1S/C25H27ClFN5O/c1-15-23(26)19(14-20(29)24(15)27)25(33)30-21-13-17(16-3-6-18(28)7-4-16)5-8-22(21)32-11-9-31(2)10-12-32/h3-8,13-14H,9-12,28-29H2,1-2H3,(H,30,33)
PDB

KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.65E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant MLL1/ASH2L/RBBP5/WDR5 complex histone methyltransferase activity (unknown origin) by AlphaScreen assay


Eur J Med Chem 124: 480-489 (2016)


Article DOI: 10.1016/j.ejmech.2016.08.036
BindingDB Entry DOI: 10.7270/Q2251M6G
More data for this
Ligand-Target Pair
Protein AF-9


(Homo sapiens)
BDBM50459746
PNG
(CHEMBL4212941)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(C)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N(C)C
Show InChI InChI=1S/C44H70N8O9/c1-10-28(6)37(49-40(57)36-19-15-21-52(36)43(60)32(23-27(4)5)45-29(7)54)41(58)48-34(25-53)38(55)46-33(24-30-16-12-11-13-17-30)44(61)51-20-14-18-35(51)39(56)47-31(22-26(2)3)42(59)50(8)9/h11-13,16-17,26-28,31-37,53H,10,14-15,18-25H2,1-9H3,(H,45,54)(H,46,55)(H,47,56)(H,48,58)(H,49,57)/t28-,31-,32-,33-,34-,35-,36-,37-/m0/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
UniChem
PubMed
n/an/a 1.66E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Displacement of N-Flu-DOT1L from MBP-tagged AF9 (unknown origin) (487 to 568 residues) expressed in Escherichia coli BL21(DE3) measured after 3 hrs b...


ACS Med Chem Lett 9: 895-900 (2018)

More data for this
Ligand-Target Pair
Protein ENL


(Homo sapiens)
BDBM50459726
PNG
(CHEMBL4211962)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CN)C(=O)N[C@@H](CC1CCCC1)C(=O)N1CCC[C@H]1c1nc(cn1C)-c1ccccc1
Show InChI InChI=1S/C43H65N9O6/c1-26(2)22-31(45-28(5)53)42(57)52-21-13-19-36(52)40(55)49-37(27(3)4)41(56)48-33(24-44)39(54)47-32(23-29-14-10-11-15-29)43(58)51-20-12-18-35(51)38-46-34(25-50(38)6)30-16-8-7-9-17-30/h7-9,16-17,25-27,29,31-33,35-37H,10-15,18-24,44H2,1-6H3,(H,45,53)(H,47,54)(H,48,56)(H,49,55)/t31-,32-,33-,35-,36-,37-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
PubMed
n/an/a 1.77E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Displacement of N-Flu-DOT1L from MBP-tagged ENL (unknown origin) (489 to 559 residues) expressed in Escherichia coli BL21(DE3) measured after 3 hrs b...


ACS Med Chem Lett 9: 895-900 (2018)

More data for this
Ligand-Target Pair
Protein AF-9


(Homo sapiens)
BDBM50459736
PNG
(CHEMBL4216206)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(C)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N(C)C
Show InChI InChI=1S/C41H72N8O9/c1-12-25(7)33(45-37(54)32-17-14-18-48(32)40(57)29(21-24(5)6)42-27(9)51)38(55)44-30(22-50)35(52)46-34(26(8)13-2)41(58)49-19-15-16-31(49)36(53)43-28(20-23(3)4)39(56)47(10)11/h23-26,28-34,50H,12-22H2,1-11H3,(H,42,51)(H,43,53)(H,44,55)(H,45,54)(H,46,52)/t25-,26-,28-,29-,30-,31-,32-,33-,34-/m0/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
UniChem
PubMed
n/an/a 1.78E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Displacement of N-Flu-DOT1L from MBP-tagged AF9 (unknown origin) (487 to 568 residues) expressed in Escherichia coli BL21(DE3) measured after 3 hrs b...


ACS Med Chem Lett 9: 895-900 (2018)

More data for this
Ligand-Target Pair
Protein ENL


(Homo sapiens)
BDBM50459733
PNG
(CHEMBL4209508)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(C)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1CCCC1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N(C)C
Show InChI InChI=1S/C43H74N8O9/c1-10-27(6)36(48-39(56)35-18-14-20-51(35)42(59)31(22-26(4)5)44-28(7)53)40(57)47-33(24-52)37(54)45-32(23-29-15-11-12-16-29)43(60)50-19-13-17-34(50)38(55)46-30(21-25(2)3)41(58)49(8)9/h25-27,29-36,52H,10-24H2,1-9H3,(H,44,53)(H,45,54)(H,46,55)(H,47,57)(H,48,56)/t27-,30-,31-,32-,33-,34-,35-,36-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
PubMed
n/an/a 2.17E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Displacement of N-Flu-DOT1L from MBP-tagged ENL (unknown origin) (489 to 559 residues) expressed in Escherichia coli BL21(DE3) measured after 3 hrs b...


ACS Med Chem Lett 9: 895-900 (2018)

More data for this
Ligand-Target Pair
Myeloid/lymphoid or mixed-lineage leukemia (MLL)


(Homo sapiens (Human))
BDBM50009672
PNG
(AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocyst...)
Show SMILES N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEBI
CHEMBL
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a 2.30E+3n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of MLL (unknown origin) by HMT assay


Bioorg Med Chem Lett 25: 1532-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.017
BindingDB Entry DOI: 10.7270/Q2TM7CSS
More data for this
Ligand-Target Pair
Protein AF-9


(Homo sapiens)
BDBM50459729
PNG
(CHEMBL4217882)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(C)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N(C)C
Show InChI InChI=1/C46H71N9O9/c1-10-28(6)39(52-42(60)38-18-14-20-55(38)45(63)34(22-27(4)5)48-29(7)57)43(61)51-36(25-56)40(58)49-35(23-30-24-47-32-16-12-11-15-31(30)32)46(64)54-19-13-17-37(54)41(59)50-33(21-26(2)3)44(62)53(8)9/h11-12,15-16,24,26-28,33-39,47,56H,10,13-14,17-23,25H2,1-9H3,(H,48,57)(H,49,58)(H,50,59)(H,51,61)(H,52,60)/t28-,33-,34-,35-,36-,37-,38-,39-/s2
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
UniChem
PubMed
n/an/a 2.37E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Displacement of N-Flu-DOT1L from MBP-tagged AF9 (unknown origin) (487 to 568 residues) expressed in Escherichia coli BL21(DE3) measured after 3 hrs b...


ACS Med Chem Lett 9: 895-900 (2018)

More data for this
Ligand-Target Pair
Protein AF-9


(Homo sapiens)
BDBM50459732
PNG
(CHEMBL4206070)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(C)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C1CCCCC1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N(C)C
Show InChI InChI=1S/C43H74N8O9/c1-10-27(6)35(47-39(56)34-19-14-20-50(34)42(59)31(23-26(4)5)44-28(7)53)40(57)46-32(24-52)37(54)48-36(29-16-12-11-13-17-29)43(60)51-21-15-18-33(51)38(55)45-30(22-25(2)3)41(58)49(8)9/h25-27,29-36,52H,10-24H2,1-9H3,(H,44,53)(H,45,55)(H,46,57)(H,47,56)(H,48,54)/t27-,30-,31-,32-,33-,34-,35-,36-/m0/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
UniChem
PubMed
n/an/a 3.49E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Displacement of N-Flu-DOT1L from MBP-tagged AF9 (unknown origin) (487 to 568 residues) expressed in Escherichia coli BL21(DE3) measured after 3 hrs b...


ACS Med Chem Lett 9: 895-900 (2018)

More data for this
Ligand-Target Pair
Protein ENL


(Homo sapiens)
BDBM50459745
PNG
(CHEMBL4210431)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(C)=O)C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N(C)C
Show InChI InChI=1S/C40H70N8O9/c1-12-25(8)33(40(57)48-18-14-15-30(48)35(52)42-27(19-22(2)3)38(55)46(10)11)45-34(51)29(21-49)43-37(54)32(24(6)7)44-36(53)31-16-13-17-47(31)39(56)28(20-23(4)5)41-26(9)50/h22-25,27-33,49H,12-21H2,1-11H3,(H,41,50)(H,42,52)(H,43,54)(H,44,53)(H,45,51)/t25-,27-,28-,29-,30-,31-,32-,33-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
PubMed
n/an/a 3.60E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Displacement of N-Flu-DOT1L from MBP-tagged ENL (unknown origin) (489 to 559 residues) expressed in Escherichia coli BL21(DE3) measured after 3 hrs b...


ACS Med Chem Lett 9: 895-900 (2018)

More data for this
Ligand-Target Pair
Protein AF-9


(Homo sapiens)
BDBM50459734
PNG
(CHEMBL4208554)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(C)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N(C)C
Show InChI InChI=1S/C48H72N8O9/c1-10-30(6)41(53-44(61)40-18-14-22-56(40)47(64)36(24-29(4)5)49-31(7)58)45(62)52-38(27-57)42(59)50-37(26-32-19-20-33-15-11-12-16-34(33)25-32)48(65)55-21-13-17-39(55)43(60)51-35(23-28(2)3)46(63)54(8)9/h11-12,15-16,19-20,25,28-30,35-41,57H,10,13-14,17-18,21-24,26-27H2,1-9H3,(H,49,58)(H,50,59)(H,51,60)(H,52,62)(H,53,61)/t30-,35-,36-,37-,38-,39-,40-,41-/m0/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
UniChem
PubMed
n/an/a 4.11E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Displacement of N-Flu-DOT1L from MBP-tagged AF9 (unknown origin) (487 to 568 residues) expressed in Escherichia coli BL21(DE3) measured after 3 hrs b...


ACS Med Chem Lett 9: 895-900 (2018)

More data for this
Ligand-Target Pair
Protein ENL


(Homo sapiens)
BDBM50459743
PNG
(CHEMBL4209087)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(C)=O)C(=O)N[C@@H](CN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N(C)C
Show InChI InChI=1S/C41H73N9O8/c1-12-25(7)33(46-37(54)32-17-14-18-49(32)40(57)29(21-24(5)6)43-27(9)51)38(55)45-30(22-42)35(52)47-34(26(8)13-2)41(58)50-19-15-16-31(50)36(53)44-28(20-23(3)4)39(56)48(10)11/h23-26,28-34H,12-22,42H2,1-11H3,(H,43,51)(H,44,53)(H,45,55)(H,46,54)(H,47,52)/t25-,26-,28-,29-,30-,31-,32-,33-,34-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
PubMed
n/an/a 4.25E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Displacement of N-Flu-DOT1L from MBP-tagged ENL (unknown origin) (489 to 559 residues) expressed in Escherichia coli BL21(DE3) measured after 3 hrs b...


ACS Med Chem Lett 9: 895-900 (2018)

More data for this
Ligand-Target Pair
Protein AF-9


(Homo sapiens)
BDBM50459740
PNG
(CHEMBL4214833)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC1CC1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N(C)C
Show InChI InChI=1S/C41H70N8O9/c1-10-25(6)34(41(58)49-18-12-14-33(49)38(55)44-29(19-23(2)3)39(56)47(8)9)46-36(53)31(22-50)45-35(52)28(21-27-15-16-27)43-37(54)32-13-11-17-48(32)40(57)30(20-24(4)5)42-26(7)51/h23-25,27-34,50H,10-22H2,1-9H3,(H,42,51)(H,43,54)(H,44,55)(H,45,52)(H,46,53)/t25-,28-,29-,30-,31-,32-,33-,34-/m0/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
UniChem
PubMed
n/an/a 4.29E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Displacement of N-Flu-DOT1L from MBP-tagged AF9 (unknown origin) (487 to 568 residues) expressed in Escherichia coli BL21(DE3) measured after 3 hrs b...


ACS Med Chem Lett 9: 895-900 (2018)

More data for this
Ligand-Target Pair
Protein ENL


(Homo sapiens)
BDBM50459748
PNG
(CHEMBL4213382)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(C)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C1CCCC1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N(C)C
Show InChI InChI=1S/C42H72N8O9/c1-10-26(6)34(46-38(55)33-18-13-19-49(33)41(58)30(22-25(4)5)43-27(7)52)39(56)45-31(23-51)36(53)47-35(28-15-11-12-16-28)42(59)50-20-14-17-32(50)37(54)44-29(21-24(2)3)40(57)48(8)9/h24-26,28-35,51H,10-23H2,1-9H3,(H,43,52)(H,44,54)(H,45,56)(H,46,55)(H,47,53)/t26-,29-,30-,31-,32-,33-,34-,35-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
PubMed
n/an/a 4.54E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Displacement of N-Flu-DOT1L from MBP-tagged ENL (unknown origin) (489 to 559 residues) expressed in Escherichia coli BL21(DE3) measured after 3 hrs b...


ACS Med Chem Lett 9: 895-900 (2018)

More data for this
Ligand-Target Pair
MLL


(Homo sapiens (Human))
BDBM50195362
PNG
(CHEMBL3907289)
Show SMILES COC(=O)c1ccc(N2CCN(C)CC2)c(NC(=O)c2cc(N)c(F)c(C)c2Cl)c1
Show InChI InChI=1S/C21H24ClFN4O3/c1-12-18(22)14(11-15(24)19(12)23)20(28)25-16-10-13(21(29)30-3)4-5-17(16)27-8-6-26(2)7-9-27/h4-5,10-11H,6-9,24H2,1-3H3,(H,25,28)
PDB

KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.60E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant MLL1 (unknown origin) interaction with recombinant ASH2L/RBBP5/WDR5 (unknown origin) assessed as decrease in histone methyl...


Bioorg Med Chem 24: 6109-6118 (2016)


Article DOI: 10.1016/j.bmc.2016.09.073
BindingDB Entry DOI: 10.7270/Q2F47R4K
More data for this
Ligand-Target Pair
Protein AF-9


(Homo sapiens)
BDBM50459724
PNG
(CHEMBL4217790)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(C)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N(C)C
Show InChI InChI=1S/C41H72N8O9/c1-12-26(8)34(46-37(54)33-16-14-18-49(33)40(57)29(20-24(4)5)42-27(9)51)38(55)45-31(22-50)35(52)43-30(21-25(6)7)41(58)48-17-13-15-32(48)36(53)44-28(19-23(2)3)39(56)47(10)11/h23-26,28-34,50H,12-22H2,1-11H3,(H,42,51)(H,43,52)(H,44,53)(H,45,55)(H,46,54)/t26-,28-,29-,30-,31-,32-,33-,34-/m0/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
UniChem
PubMed
n/an/a 4.66E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Displacement of N-Flu-DOT1L from MBP-tagged AF9 (unknown origin) (487 to 568 residues) expressed in Escherichia coli BL21(DE3) measured after 3 hrs b...


ACS Med Chem Lett 9: 895-900 (2018)

More data for this
Ligand-Target Pair
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