BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1466 hits Enz. Inhib. hit(s) with Target = 'Macrophage colony-stimulating factor 1 receptor (c-Fms)'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Macrophage colony stimulating factor receptor


(Homo sapiens (human))
BDBM50377072
PNG
(CHEMBL438533)
Show SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1ccc(o1)C#N)C1CCNCC1
Show InChI InChI=1S/C23H28N4O2/c1-16-8-12-27(13-9-16)21-14-18(17-6-10-25-11-7-17)2-4-20(21)26-23(28)22-5-3-19(15-24)29-22/h2-5,14,16-17,25H,6-13H2,1H3,(H,26,28)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.300n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of FMS mediated phosphorylation using SYEGNSYTFIDPTQ as substrate after 80 mins by fluorescence polarization


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (human))
BDBM27912
PNG
(8-(4-ethylphenyl)-N-methoxy-2-{[4-(1-methylpiperid...)
Show SMILES CCc1ccc(cc1)-n1cc(C(=O)NOC)c(=O)c2cnc(Nc3ccc(cc3)C3CCN(C)CC3)nc12
Show InChI InChI=1S/C29H32N6O3/c1-4-19-5-11-23(12-6-19)35-18-25(28(37)33-38-3)26(36)24-17-30-29(32-27(24)35)31-22-9-7-20(8-10-22)21-13-15-34(2)16-14-21/h5-12,17-18,21H,4,13-16H2,1-3H3,(H,33,37)(H,30,31,32)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 0.300n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (human))
BDBM50321368
PNG
(4-cyano-N-(4-(1,3-dimethyl-2-oxohexahydropyrimidin...)
Show SMILES CN1CC(CN(C)C1=O)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C25H30N6O2/c1-25(2)9-7-16(8-10-25)20-11-17(18-14-30(3)24(33)31(4)15-18)5-6-21(20)29-23(32)22-27-13-19(12-26)28-22/h5-7,11,13,18H,8-10,14-15H2,1-4H3,(H,27,28)(H,29,32)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.300n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human FMS by fluorescence polarization


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (human))
BDBM50377072
PNG
(CHEMBL438533)
Show SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1ccc(o1)C#N)C1CCNCC1
Show InChI InChI=1S/C23H28N4O2/c1-16-8-12-27(13-9-16)21-14-18(17-6-10-25-11-7-17)2-4-20(21)26-23(28)22-5-3-19(15-24)29-22/h2-5,14,16-17,25H,6-13H2,1H3,(H,26,28)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.300n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of FMS


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (human))
BDBM27915
PNG
(8-(4,4-dimethylcyclohexyl)-N-methoxy-2-{[4-(1-meth...)
Show SMILES CONC(=O)c1cn(C2CCC(C)(C)CC2)c2nc(Nc3ccc(cc3)C3CCN(C)CC3)ncc2c1=O
Show InChI InChI=1S/C29H38N6O3/c1-29(2)13-9-22(10-14-29)35-18-24(27(37)33-38-4)25(36)23-17-30-28(32-26(23)35)31-21-7-5-19(6-8-21)20-11-15-34(3)16-12-20/h5-8,17-18,20,22H,9-16H2,1-4H3,(H,33,37)(H,30,31,32)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 0.400n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (human))
BDBM27913
PNG
(8-(3-ethylphenyl)-N-methoxy-2-{[4-(1-methylpiperid...)
Show SMILES CCc1cccc(c1)-n1cc(C(=O)NOC)c(=O)c2cnc(Nc3ccc(cc3)C3CCN(C)CC3)nc12
Show InChI InChI=1S/C29H32N6O3/c1-4-19-6-5-7-23(16-19)35-18-25(28(37)33-38-3)26(36)24-17-30-29(32-27(24)35)31-22-10-8-20(9-11-22)21-12-14-34(2)15-13-21/h5-11,16-18,21H,4,12-15H2,1-3H3,(H,33,37)(H,30,31,32)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 0.400n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (human))
BDBM50377071
PNG
(CHEMBL402337)
Show SMILES CC1CCC(=CC1)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)C1CCNCC1
Show InChI InChI=1S/C23H27N5O/c1-15-2-4-17(5-3-15)20-12-18(16-8-10-25-11-9-16)6-7-21(20)28-23(29)22-26-14-19(13-24)27-22/h4,6-7,12,14-16,25H,2-3,5,8-11H2,1H3,(H,26,27)(H,28,29)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.400n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of FMS


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (human))
BDBM50321373
PNG
(4-cyano-N-(4-(2-(cyanoimino)-1,3-dimethylhexahydro...)
Show SMILES CN1CC(CN(C)C1=NC#N)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C26H30N8O/c1-26(2)9-7-17(8-10-26)21-11-18(19-14-33(3)25(30-16-28)34(4)15-19)5-6-22(21)32-24(35)23-29-13-20(12-27)31-23/h5-7,11,13,19H,8-10,14-15H2,1-4H3,(H,29,31)(H,32,35)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.400n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human FMS by fluorescence polarization


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (human))
BDBM27909
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-N-methoxy-2-{[4-(1-m...)
Show SMILES CONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(cc3)C3CCN(C)CC3)ncc2c1=O
Show InChI InChI=1S/C30H32N6O3/c1-35-14-12-21(13-15-35)20-6-9-23(10-7-20)32-30-31-17-25-27(37)26(29(38)34-39-2)18-36(28(25)33-30)24-11-8-19-4-3-5-22(19)16-24/h6-11,16-18,21H,3-5,12-15H2,1-2H3,(H,34,38)(H,31,32,33)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 0.400n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM98644
PNG
(US8497376, 20)
Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1ncc([nH]1)C#N)C1C[C@@](C)(CO)O[C@@](C)(CO)C1
Show InChI InChI=1S/C27H35N5O4/c1-25(2)9-7-17(8-10-25)22-21(32-24(35)23-29-14-19(13-28)30-23)6-5-20(31-22)18-11-26(3,15-33)36-27(4,12-18)16-34/h5-7,14,18,33-34H,8-12,15-16H2,1-4H3,(H,29,30)(H,32,35)/t18?,26-,27+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.410n/an/an/an/a7.5n/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.


US Patent US8497376 (2013)

More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM98627
PNG
(US8497376, 8)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1nc(c[nH]1)[N+]#[C-])[C@]1(O)C[C@@]2(CO)CC[C@@](CO)(C1)O2
Show InChI InChI=1S/C28H34N4O5/c1-25(2)8-6-18(7-9-25)20-12-19(4-5-21(20)31-24(35)23-30-13-22(29-3)32-23)28(36)14-26(16-33)10-11-27(15-28,17-34)37-26/h4-6,12-13,33-34,36H,7-11,14-17H2,1-2H3,(H,30,32)(H,31,35)/t26-,27+,28+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.420n/an/an/an/a7.5n/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.


US Patent US8497376 (2013)

More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM98621
PNG
(US8497376, 2)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)[C@]1(O)C[C@]2(CO)O[C@](CO)(C1)C=C2
Show InChI InChI=1S/C28H32N4O5/c1-25(2)7-5-18(6-8-25)21-11-19(3-4-22(21)32-24(35)23-30-13-20(12-29)31-23)28(36)14-26(16-33)9-10-27(15-28,17-34)37-26/h3-5,9-11,13,33-34,36H,6-8,14-17H2,1-2H3,(H,30,31)(H,32,35)/t26-,27+,28+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.430n/an/an/an/a7.5n/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.


US Patent US8497376 (2013)

More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM119049
PNG
(CHEMBL3086320 | US8674100, 20 | US8674100, 69)
Show SMILES COCCNC(C)(C)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C25H33N5O2/c1-24(2)10-8-17(9-11-24)20-14-18(25(3,4)28-12-13-32-5)6-7-21(20)30-23(31)22-27-16-19(15-26)29-22/h6-8,14,16,28H,9-13H2,1-5H3,(H,27,29)(H,30,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.440n/an/an/an/an/an/a



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...


US Patent US8674100 (2014)

More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM98624
PNG
(US8497376, 5)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)[C@H]1C[C@@]2(CO)CC[C@@](CO)(C1)O2
Show InChI InChI=1S/C28H34N4O4/c1-26(2)7-5-18(6-8-26)22-11-19(20-12-27(16-33)9-10-28(13-20,17-34)36-27)3-4-23(22)32-25(35)24-30-15-21(14-29)31-24/h3-5,11,15,20,33-34H,6-10,12-13,16-17H2,1-2H3,(H,30,31)(H,32,35)/t20-,27+,28-
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.470n/an/an/an/a7.5n/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.


US Patent US8497376 (2013)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (human))
BDBM27896
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-N-ethoxy-2-({4-[2-(4...)
Show SMILES CCONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(CCN4CCN(C)CC4)cc3)ncc2c1=O
Show InChI InChI=1S/C32H37N7O3/c1-3-42-36-31(41)28-21-39(26-12-9-23-5-4-6-24(23)19-26)30-27(29(28)40)20-33-32(35-30)34-25-10-7-22(8-11-25)13-14-38-17-15-37(2)16-18-38/h7-12,19-21H,3-6,13-18H2,1-2H3,(H,36,41)(H,33,34,35)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 0.5n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (human))
BDBM27897
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-2-({4-[2-(4-methylpi...)
Show SMILES CC(C)ONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(CCN4CCN(C)CC4)cc3)ncc2c1=O
Show InChI InChI=1S/C33H39N7O3/c1-22(2)43-37-32(42)29-21-40(27-12-9-24-5-4-6-25(24)19-27)31-28(30(29)41)20-34-33(36-31)35-26-10-7-23(8-11-26)13-14-39-17-15-38(3)16-18-39/h7-12,19-22H,4-6,13-18H2,1-3H3,(H,37,42)(H,34,35,36)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 0.5n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (human))
BDBM50321365
PNG
(4-cyano-N-(2-cyclohexenyl-4-(1-methyl-2,6-dioxopip...)
Show SMILES CN1C(=O)CC(CC1=O)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C23H23N5O3/c1-28-20(29)10-16(11-21(28)30)15-7-8-19(18(9-15)14-5-3-2-4-6-14)27-23(31)22-25-13-17(12-24)26-22/h5,7-9,13,16H,2-4,6,10-11H2,1H3,(H,25,26)(H,27,31)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 0.5n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human FMS by fluorescence polarization


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (human))
BDBM50321367
PNG
(4-cyano-N-(2-cyclohexenyl-4-(1,3-dimethyl-2-oxohex...)
Show SMILES CN1CC(CN(C)C1=O)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C23H26N6O2/c1-28-13-17(14-29(2)23(28)31)16-8-9-20(19(10-16)15-6-4-3-5-7-15)27-22(30)21-25-12-18(11-24)26-21/h6,8-10,12,17H,3-5,7,13-14H2,1-2H3,(H,25,26)(H,27,30)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.5n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human FMS by fluorescence polarization


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (human))
BDBM27906
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-N-methoxy-5-oxo-2-{[...)
Show SMILES CONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(cc3)C3CCNCC3)ncc2c1=O
Show InChI InChI=1S/C29H30N6O3/c1-38-34-28(37)25-17-35(23-10-7-18-3-2-4-21(18)15-23)27-24(26(25)36)16-31-29(33-27)32-22-8-5-19(6-9-22)20-11-13-30-14-12-20/h5-10,15-17,20,30H,2-4,11-14H2,1H3,(H,34,37)(H,31,32,33)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 0.5n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM119049
PNG
(CHEMBL3086320 | US8674100, 20 | US8674100, 69)
Show SMILES COCCNC(C)(C)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C25H33N5O2/c1-24(2)10-8-17(9-11-24)20-14-18(25(3,4)28-12-13-32-5)6-7-21(20)30-23(31)22-27-16-19(15-26)29-22/h6-8,14,16,28H,9-13H2,1-5H3,(H,27,29)(H,30,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.510n/an/an/an/an/an/a



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...


US Patent US8674100 (2014)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (human))
BDBM50233716
PNG
(5-cyano-N-(4-(4-(2-hydroxyethyl)piperazin-1-yl)-2-...)
Show SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1ccc(o1)C#N)N1CCN(CCO)CC1
Show InChI InChI=1S/C24H31N5O3/c1-18-6-8-29(9-7-18)22-16-19(28-12-10-27(11-13-28)14-15-30)2-4-21(22)26-24(31)23-5-3-20(17-25)32-23/h2-5,16,18,30H,6-15H2,1H3,(H,26,31)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 0.600n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarization


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM119032
PNG
(US8674100, 45)
Show SMILES CC(C)(N1CCCC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C26H33N5O/c1-25(2)11-9-18(10-12-25)21-15-19(26(3,4)31-13-5-6-14-31)7-8-22(21)30-24(32)23-28-17-20(16-27)29-23/h7-9,15,17H,5-6,10-14H2,1-4H3,(H,28,29)(H,30,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.600n/an/an/an/an/an/a



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...


US Patent US8674100 (2014)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (human))
BDBM119049
PNG
(CHEMBL3086320 | US8674100, 20 | US8674100, 69)
Show SMILES COCCNC(C)(C)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C25H33N5O2/c1-24(2)10-8-17(9-11-24)20-14-18(25(3,4)28-12-13-32-5)6-7-21(20)30-23(31)22-27-16-19(15-26)29-22/h6-8,14,16,28H,9-13H2,1-5H3,(H,27,29)(H,30,31)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.600n/an/an/an/an/an/a



Janssen Pharmaceutical Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of FMS (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (human))
BDBM50443154
PNG
(CHEMBL3085973 | US8674100, 147)
Show SMILES COCCNCC(C)(C)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C26H35N5O2/c1-25(2)10-8-18(9-11-25)21-14-19(26(3,4)17-28-12-13-33-5)6-7-22(21)31-24(32)23-29-16-20(15-27)30-23/h6-8,14,16,28H,9-13,17H2,1-5H3,(H,29,30)(H,31,32)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.600n/an/an/an/an/an/a



Janssen Pharmaceutical Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of FMS (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (human))
BDBM50393560
PNG
(CHEMBL2158300 | US8697716, 48)
Show SMILES CC(C)(N)CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C27H34N6O2/c1-27(2,29)15-24(34)33-12-10-18(11-13-33)20-8-9-23(22(14-20)19-6-4-3-5-7-19)32-26(35)25-30-17-21(16-28)31-25/h6,8-9,14,17-18H,3-5,7,10-13,15,29H2,1-2H3,(H,30,31)(H,32,35)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.620n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of FMS mediated phosphorylation using SYEGNSYTFIDPTQ as substrate after 80 mins by fluorescence polarization


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM50393549
PNG
(CHEMBL2158289)
Show SMILES CN(CCO)CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C27H34N6O3/c1-32(13-14-34)18-25(35)33-11-9-19(10-12-33)21-7-8-24(23(15-21)20-5-3-2-4-6-20)31-27(36)26-29-17-22(16-28)30-26/h5,7-8,15,17,19,34H,2-4,6,9-14,18H2,1H3,(H,29,30)(H,31,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.640n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of FMS-mediated proliferation in CSF1-stimulated bone marrow-derived mouse macrophages assessed as inhibition of incorporation of bromodeo...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM50443154
PNG
(CHEMBL3085973 | US8674100, 147)
Show SMILES COCCNCC(C)(C)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C26H35N5O2/c1-25(2)10-8-18(9-11-25)21-14-19(26(3,4)17-28-12-13-33-5)6-7-22(21)31-24(32)23-29-16-20(15-27)30-23/h6-8,14,16,28H,9-13,17H2,1-5H3,(H,29,30)(H,31,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.640n/an/an/an/an/an/a



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...


US Patent US8674100 (2014)

More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM98622
PNG
(US8497376, 3)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)C1=C[C@]2(CO)O[C@](CO)(C1)C=C2
Show InChI InChI=1S/C28H30N4O4/c1-26(2)7-5-18(6-8-26)22-11-19(20-12-27(16-33)9-10-28(13-20,17-34)36-27)3-4-23(22)32-25(35)24-30-15-21(14-29)31-24/h3-5,9-12,15,33-34H,6-8,13,16-17H2,1-2H3,(H,30,31)(H,32,35)/t27-,28+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.650n/an/an/an/a7.5n/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.


US Patent US8497376 (2013)

More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM98631
PNG
(US8497376, 12)
Show SMILES C[C@@]12C[C@](O)(C[C@@](C)(O1)[C@@H](O)[C@H]2O)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C28H34N4O5/c1-25(2)9-7-16(8-10-25)19-11-17(5-6-20(19)32-24(35)23-30-13-18(12-29)31-23)28(36)14-26(3)21(33)22(34)27(4,15-28)37-26/h5-7,11,13,21-22,33-34,36H,8-10,14-15H2,1-4H3,(H,30,31)(H,32,35)/t21-,22+,26+,27-,28+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.660n/an/an/an/a7.5n/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.


US Patent US8497376 (2013)

More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM98648
PNG
(US8497376, 27)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)[C@@]1(O)CC2O[C@@H](C1)C=C2
Show InChI InChI=1S/C26H28N4O3/c1-25(2)9-7-16(8-10-25)21-11-17(26(32)12-19-4-5-20(13-26)33-19)3-6-22(21)30-24(31)23-28-15-18(14-27)29-23/h3-7,11,15,19-20,32H,8-10,12-13H2,1-2H3,(H,28,29)(H,30,31)/t19-,20?,26+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.660n/an/an/an/a7.5n/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.


US Patent US8497376 (2013)

More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM50443167
PNG
(CHEMBL3085977 | US8674100, 76)
Show SMILES CC(=O)NCCNC(C)(C)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C26H34N6O2/c1-17(33)28-12-13-30-26(4,5)19-6-7-22(32-24(34)23-29-16-20(15-27)31-23)21(14-19)18-8-10-25(2,3)11-9-18/h6-8,14,16,30H,9-13H2,1-5H3,(H,28,33)(H,29,31)(H,32,34)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.680n/an/an/an/an/an/a



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...


US Patent US8674100 (2014)

More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM119044
PNG
(CHEMBL3085833 | US8674100, 62 | US8674100, 63)
Show SMILES CC(C)(N1CCN(CCO)CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C28H38N6O2/c1-27(2)9-7-20(8-10-27)23-17-21(28(3,4)34-13-11-33(12-14-34)15-16-35)5-6-24(23)32-26(36)25-30-19-22(18-29)31-25/h5-7,17,19,35H,8-16H2,1-4H3,(H,30,31)(H,32,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.690n/an/an/an/an/an/a



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...


US Patent US8674100 (2014)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (human))
BDBM50355499
PNG
(CHEMBL1908395 | CHEMBL1908842)
Show SMILES CN(C)CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C26H32N6O2/c1-31(2)17-24(33)32-12-10-18(11-13-32)20-8-9-23(22(14-20)19-6-4-3-5-7-19)30-26(34)25-28-16-21(15-27)29-25/h6,8-9,14,16,18H,3-5,7,10-13,17H2,1-2H3,(H,28,29)(H,30,34)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.690n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of FMS


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (human))
BDBM50355499
PNG
(CHEMBL1908395 | CHEMBL1908842)
Show SMILES CN(C)CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C26H32N6O2/c1-31(2)17-24(33)32-12-10-18(11-13-32)20-8-9-23(22(14-20)19-6-4-3-5-7-19)30-26(34)25-28-16-21(15-27)29-25/h6,8-9,14,16,18H,3-5,7,10-13,17H2,1-2H3,(H,28,29)(H,30,34)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.690n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of FMS mediated phosphorylation using SYEGNSYTFIDPTQ as substrate after 80 mins by fluorescence polarization


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (human))
BDBM50233720
PNG
(CHEMBL254909 | N-(4-(4-acetylpiperazin-1-yl)-2-(4-...)
Show SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1cc(c[nH]1)C#N)N1CCN(CC1)C(C)=O
Show InChI InChI=1S/C24H30N6O2/c1-17-5-7-30(8-6-17)23-14-20(29-11-9-28(10-12-29)18(2)31)3-4-21(23)27-24(32)22-13-19(15-25)16-26-22/h3-4,13-14,16-17,26H,5-12H2,1-2H3,(H,27,32)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 0.700n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarization


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (human))
BDBM27910
PNG
(2-{[4-(3,3-difluoro-1-methylpiperidin-4-yl)phenyl]...)
Show SMILES CONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(cc3)C3CCN(C)CC3(F)F)ncc2c1=O
Show InChI InChI=1S/C30H30F2N6O3/c1-37-13-12-25(30(31,32)17-37)19-6-9-21(10-7-19)34-29-33-15-23-26(39)24(28(40)36-41-2)16-38(27(23)35-29)22-11-8-18-4-3-5-20(18)14-22/h6-11,14-16,25H,3-5,12-13,17H2,1-2H3,(H,36,40)(H,33,34,35)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 0.700n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (human))
BDBM27894
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-N-(2-hydroxyethyl)-2...)
Show SMILES CN1CCN(CCc2ccc(Nc3ncc4c(n3)n(cc(C(=O)NCCO)c4=O)-c3ccc4CCCc4c3)cc2)CC1
Show InChI InChI=1S/C32H37N7O3/c1-37-14-16-38(17-15-37)13-11-22-5-8-25(9-6-22)35-32-34-20-27-29(41)28(31(42)33-12-18-40)21-39(30(27)36-32)26-10-7-23-3-2-4-24(23)19-26/h5-10,19-21,40H,2-4,11-18H2,1H3,(H,33,42)(H,34,35,36)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 0.700n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (human))
BDBM50393562
PNG
(CHEMBL2158302)
Show SMILES OCCNC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C25H30N6O3/c26-15-20-16-28-23(29-20)24(33)30-22-7-6-19(14-21(22)18-4-2-1-3-5-18)17-8-11-31(12-9-17)25(34)27-10-13-32/h4,6-7,14,16-17,32H,1-3,5,8-13H2,(H,27,34)(H,28,29)(H,30,33)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.700n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of FMS mediated phosphorylation using SYEGNSYTFIDPTQ as substrate after 80 mins by fluorescence polarization


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (human))
BDBM27895
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-N-methoxy-2-({4-[2-(...)
Show SMILES CONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(CCN4CCN(C)CC4)cc3)ncc2c1=O
Show InChI InChI=1S/C31H35N7O3/c1-36-14-16-37(17-15-36)13-12-21-6-9-24(10-7-21)33-31-32-19-26-28(39)27(30(40)35-41-2)20-38(29(26)34-31)25-11-8-22-4-3-5-23(22)18-25/h6-11,18-20H,3-5,12-17H2,1-2H3,(H,35,40)(H,32,33,34)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 0.700n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (human))
BDBM50443167
PNG
(CHEMBL3085977 | US8674100, 76)
Show SMILES CC(=O)NCCNC(C)(C)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C26H34N6O2/c1-17(33)28-12-13-30-26(4,5)19-6-7-22(32-24(34)23-29-16-20(15-27)31-23)21(14-19)18-8-10-25(2,3)11-9-18/h6-8,14,16,30H,9-13H2,1-5H3,(H,28,33)(H,29,31)(H,32,34)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.700n/an/an/an/an/an/a



Janssen Pharmaceutical Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of FMS (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (human))
BDBM50233701
PNG
(5-cyano-furan-2-carboxylic acid [4-(1,1-dioxo-1lam...)
Show SMILES O=C(Nc1ccc(cc1N1CCCCC1)N1CCS(=O)(=O)CC1)c1ccc(o1)C#N
Show InChI InChI=1S/C21H24N4O4S/c22-15-17-5-7-20(29-17)21(26)23-18-6-4-16(24-10-12-30(27,28)13-11-24)14-19(18)25-8-2-1-3-9-25/h4-7,14H,1-3,8-13H2,(H,23,26)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 0.700n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarization


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (human))
BDBM119044
PNG
(CHEMBL3085833 | US8674100, 62 | US8674100, 63)
Show SMILES CC(C)(N1CCN(CCO)CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C28H38N6O2/c1-27(2)9-7-20(8-10-27)23-17-21(28(3,4)34-13-11-33(12-14-34)15-16-35)5-6-24(23)32-26(36)25-30-19-22(18-29)31-25/h5-7,17,19,35H,8-16H2,1-4H3,(H,30,31)(H,32,36)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.700n/an/an/an/an/an/a



Janssen Pharmaceutical Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of FMS (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM98623
PNG
(US8497376, 4)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)[C@@H]1C[C@@]2(CO)CC[C@@](CO)(C1)O2
Show InChI InChI=1S/C28H34N4O4/c1-26(2)7-5-18(6-8-26)22-11-19(20-12-27(16-33)9-10-28(13-20,17-34)36-27)3-4-23(22)32-25(35)24-30-15-21(14-29)31-24/h3-5,11,15,20,33-34H,6-10,12-13,16-17H2,1-2H3,(H,30,31)(H,32,35)/t20-,27-,28+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.720n/an/an/an/a7.5n/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.


US Patent US8497376 (2013)

More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM98642
PNG
(US8497376, 18)
Show SMILES C[C@@]12CC(C[C@@](C)(O1)[C@@H](O)[C@H]2O)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(n1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C27H33N5O4/c1-25(2)9-7-15(8-10-25)20-19(32-24(35)23-29-14-17(13-28)30-23)6-5-18(31-20)16-11-26(3)21(33)22(34)27(4,12-16)36-26/h5-7,14,16,21-22,33-34H,8-12H2,1-4H3,(H,29,30)(H,32,35)/t16?,21-,22+,26+,27-
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.720n/an/an/an/a7.5n/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.


US Patent US8497376 (2013)

More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM50443140
PNG
(CHEMBL3085984 | US8674100, 150)
Show SMILES CC1(C)CCC(=CC1)c1cc(CN2CCN(CCO)CC2)ccc1NC(=O)c1ncc([nH]1)C#N
Show InChI InChI=1S/C26H34N6O2/c1-26(2)7-5-20(6-8-26)22-15-19(18-32-11-9-31(10-12-32)13-14-33)3-4-23(22)30-25(34)24-28-17-21(16-27)29-24/h3-5,15,17,33H,6-14,18H2,1-2H3,(H,28,29)(H,30,34)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.75n/an/an/an/an/an/a



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...


US Patent US8674100 (2014)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (human))
BDBM27917
PNG
(4-cyano-N-[4-(4-methylpiperazin-1-yl)-2-(4-methylp...)
Show SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1cc(c[nH]1)C#N)N1CCN(C)CC1
Show InChI InChI=1S/C23H30N6O/c1-17-5-7-29(8-6-17)22-14-19(28-11-9-27(2)10-12-28)3-4-20(22)26-23(30)21-13-18(15-24)16-25-21/h3-4,13-14,16-17,25H,5-12H2,1-2H3,(H,26,30)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 0.780n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarization


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (human))
BDBM27911
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-2-{[3-(1-ethyl-3-hyd...)
Show SMILES CCN1CCCC(O)(C1)c1cccc(Nc2ncc3c(n2)n(cc(C(=O)NOC)c3=O)-c2ccc3CCCc3c2)c1
Show InChI InChI=1S/C31H34N6O4/c1-3-36-14-6-13-31(40,19-36)22-9-5-10-23(16-22)33-30-32-17-25-27(38)26(29(39)35-41-2)18-37(28(25)34-30)24-12-11-20-7-4-8-21(20)15-24/h5,9-12,15-18,40H,3-4,6-8,13-14,19H2,1-2H3,(H,35,39)(H,32,33,34)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 0.800n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (human))
BDBM27904
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-N-methoxy-2-({4-[2-(...)
Show SMILES CONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(CCN4CCN(C)C(=O)C4)cc3)ncc2c1=O
Show InChI InChI=1S/C31H33N7O4/c1-36-14-15-37(19-27(36)39)13-12-20-6-9-23(10-7-20)33-31-32-17-25-28(40)26(30(41)35-42-2)18-38(29(25)34-31)24-11-8-21-4-3-5-22(21)16-24/h6-11,16-18H,3-5,12-15,19H2,1-2H3,(H,35,41)(H,32,33,34)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 0.800n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (human))
BDBM27903
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-N-methoxy-5-oxo-2-({...)
Show SMILES CONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(CCN4CCNC(=O)C4)cc3)ncc2c1=O
Show InChI InChI=1S/C30H31N7O4/c1-41-35-29(40)25-17-37(23-10-7-20-3-2-4-21(20)15-23)28-24(27(25)39)16-32-30(34-28)33-22-8-5-19(6-9-22)11-13-36-14-12-31-26(38)18-36/h5-10,15-17H,2-4,11-14,18H2,1H3,(H,31,38)(H,35,40)(H,32,33,34)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 0.800n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (human))
BDBM27917
PNG
(4-cyano-N-[4-(4-methylpiperazin-1-yl)-2-(4-methylp...)
Show SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1cc(c[nH]1)C#N)N1CCN(C)CC1
Show InChI InChI=1S/C23H30N6O/c1-17-5-7-29(8-6-17)22-14-19(28-11-9-27(2)10-12-28)3-4-20(22)26-23(30)21-13-18(15-24)16-25-21/h3-4,13-14,16-17,25H,5-12H2,1-2H3,(H,26,30)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 0.800n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...


Citation and Details
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 1466 total )  |  Next  |  Last  >>
Jump to: