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Compile Data Set for Download or QSAR

Found 211 hits Enz. Inhib. hit(s) with Target = 'Macrophage-stimulating protein receptor'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50146164
PNG
(CHEMBL2143592)
Show SMILES Nc1nccc(Oc2ccc(NC(=O)c3c[nH]cc(-c4ccc(F)cc4)c3=O)cc2F)c1Cl
Show InChI InChI=1S/C23H15ClF2N4O3/c24-20-19(7-8-29-22(20)27)33-18-6-5-14(9-17(18)26)30-23(32)16-11-28-10-15(21(16)31)12-1-3-13(25)4-2-12/h1-11H,(H2,27,29)(H,28,31)(H,30,32)
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n/an/a<3n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Ron (unknown origin)


Eur J Med Chem 108: 495-504 (2016)

More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50399540
PNG
(FORETINIB)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)
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n/an/a 3n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of RON (unknown origin) using poly(Glu, Tyr) 4:1 as substrate preincubated for 60 mins followed by substrate addition measured after 2 to ...


Eur J Med Chem 108: 495-504 (2016)

More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50399540
PNG
(FORETINIB)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)
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n/an/a 3.40n/an/an/an/an/an/a



Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, 103 Wenhua Road, Shenhe District, PR China.

Curated by ChEMBL


Assay Description
Inhibition of RON (unknown origin)


Eur J Med Chem 87: 508-18 (2014)

More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50399540
PNG
(FORETINIB)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)
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n/an/a 3.40n/an/an/an/an/an/a



Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University)

Curated by ChEMBL


Assay Description
Inhibition of Ron (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay


Bioorg Med Chem 23: 4410-22 (2015)

More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50399540
PNG
(FORETINIB)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)
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n/an/a 3.52n/an/an/an/an/an/a



Shenyang Pharmaceutical University, Ministry of Education



Assay Description
The c-Met kinase activity was evaluated by homogeneous time-resolved fluorescence (HTRF) assays. In a 384-well plate, 20 µg/mL (Glue, Tyr) 4:1 w...


Bioorg Chem 57: 30-42 (2014)

More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM120816
PNG
((Z)-4-(((3-fluoro-4-((6-methoxy-7-(3-morpholinopro...)
Show SMILES COc1cc2c(Oc3ccc(cc3F)N=Cc3c(C)[nH]n(-c4ccccc4C(F)(F)F)c3=O)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C35H33F4N5O5/c1-22-25(34(45)44(42-22)29-7-4-3-6-26(29)35(37,38)39)21-41-23-8-9-31(27(36)18-23)49-30-10-11-40-28-20-33(32(46-2)19-24(28)30)48-15-5-12-43-13-16-47-17-14-43/h3-4,6-11,18-21,42H,5,12-17H2,1-2H3/b41-21+
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n/an/a 4.24n/an/an/an/an/an/a



Shenyang Pharmaceutical University, Ministry of Education



Assay Description
The c-Met kinase activity was evaluated by homogeneous time-resolved fluorescence (HTRF) assays. In a 384-well plate, 20 µg/mL (Glue, Tyr) 4:1 w...


Bioorg Chem 57: 30-42 (2014)

More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50347681
PNG
(CHEMBL1802829)
Show SMILES CN(C)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1
Show InChI InChI=1S/C20H19N5O3S/c1-24(2)29(27,28)23-16-6-4-13-5-7-19-18(20(26)17(13)9-16)8-14(10-21-19)15-11-22-25(3)12-15/h4-12,23H,1-3H3
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n/an/a 7n/an/an/an/an/an/a



Merck& Co., Inc.

Curated by ChEMBL


Assay Description
Inhibition of RON (unknown origin) by TR-FRET assay


J Med Chem 56: 2294-310 (2013)

More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50347659
PNG
(CHEMBL1802916 | MK-2461)
Show SMILES CN(C[C@@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1
Show InChI InChI=1S/C24H25N5O5S/c1-28-13-18(12-26-28)17-9-22-23(25-11-17)6-4-16-3-5-19(10-21(16)24(22)30)27-35(31,32)29(2)14-20-15-33-7-8-34-20/h3-6,9-13,20,27H,7-8,14-15H2,1-2H3/t20-/m1/s1
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n/an/a 7n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human Ron


J Med Chem 54: 4092-108 (2011)

More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50427138
PNG
(CHEMBL2323775 | MK-8033)
Show SMILES Cn1cc(cn1)-c1cnc2ccc3ccc(CS(=O)(=O)NCc4ccccn4)cc3c(=O)c2c1
Show InChI InChI=1S/C25H21N5O3S/c1-30-15-20(13-28-30)19-11-23-24(27-12-19)8-7-18-6-5-17(10-22(18)25(23)31)16-34(32,33)29-14-21-4-2-3-9-26-21/h2-13,15,29H,14,16H2,1H3
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n/an/a 7n/an/an/an/an/an/a



Merck& Co., Inc.

Curated by ChEMBL


Assay Description
Inhibition of RON (unknown origin) by TR-FRET assay


J Med Chem 56: 2294-310 (2013)

More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50317323
PNG
(CHEMBL1094718 | N-(3-fluoro-4-(2-(1-methyl-1H-imid...)
Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C28H18F4N6O2S/c1-37-14-21(34-15-37)24-12-20-25(41-24)23(9-10-33-20)40-22-8-7-16(11-19(22)29)36-27(39)18-13-35-38(26(18)28(30,31)32)17-5-3-2-4-6-17/h2-15H,1H3,(H,36,39)
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n/an/a 10n/an/an/an/an/an/a



Laboratoires ChemRF Inc. / ChemRF Laboratories Inc.

Curated by ChEMBL


Assay Description
Inhibition of human RON


Bioorg Med Chem Lett 25: 3706-10 (2015)

More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM24466
PNG
(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)(C)O)n(-c5ccccc5)c4=O)nc3)ccnc2c1
Show InChI InChI=1S/C30H29N5O5/c1-19-27(29(37)35(20-8-6-5-7-9-20)34(19)18-30(2,3)38)28(36)33-26-13-11-22(17-32-26)40-25-14-15-31-24-16-21(39-4)10-12-23(24)25/h5-17,38H,18H2,1-4H3,(H,32,33,36)
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n/an/a 10n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of RON by HTRF assay


J Med Chem 55: 1868-97 (2012)

More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50091030
PNG
(CHEMBL3582033)
Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4ccn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C13H21N3/c1-2-5-16-6-3-4-10-7-12-11(8-13(10)16)9-14-15-12/h9-10,13H,2-8H2,1H3,(H,14,15)/p+1/t10-,13-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



ChemRF Laboratories

Curated by ChEMBL


Assay Description
Inhibition of RON (unknown origin) transfected in 293T cells assessed as autophosporylated level by ELISA


Bioorg Med Chem Lett 25: 2527-31 (2015)

More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50317323
PNG
(CHEMBL1094718 | N-(3-fluoro-4-(2-(1-methyl-1H-imid...)
Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C28H18F4N6O2S/c1-37-14-21(34-15-37)24-12-20-25(41-24)23(9-10-33-20)40-22-8-7-16(11-19(22)29)36-27(39)18-13-35-38(26(18)28(30,31)32)17-5-3-2-4-6-17/h2-15H,1H3,(H,36,39)
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n/an/a 12n/an/an/an/an/an/a



ChemRF Laboratories

Curated by ChEMBL


Assay Description
Inhibition of RON (unknown origin) transfected in 293T cells assessed as autophosporylated level by ELISA


Bioorg Med Chem Lett 25: 2527-31 (2015)

More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50317323
PNG
(CHEMBL1094718 | N-(3-fluoro-4-(2-(1-methyl-1H-imid...)
Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C28H18F4N6O2S/c1-37-14-21(34-15-37)24-12-20-25(41-24)23(9-10-33-20)40-22-8-7-16(11-19(22)29)36-27(39)18-13-35-38(26(18)28(30,31)32)17-5-3-2-4-6-17/h2-15H,1H3,(H,36,39)
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n/an/a 12n/an/an/an/an/an/a



Laboratoires ChemRF Inc./ChemRF Laboratories Inc.

Curated by ChEMBL


Assay Description
Inhibition of human RON


Bioorg Med Chem Lett 25: 3810-5 (2015)

More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50090969
PNG
(CHEMBL3582034)
Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4ncn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C28H18F4N6O2S/c1-37-13-20(34-14-37)23-12-19-25(41-23)22(9-10-33-19)40-21-8-7-16(11-18(21)29)36-27(39)24-26(28(30,31)32)38(15-35-24)17-5-3-2-4-6-17/h2-15H,1H3,(H,36,39)
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n/an/a 13n/an/an/an/an/an/a



ChemRF Laboratories

Curated by ChEMBL


Assay Description
Inhibition of RON (unknown origin) transfected in 293T cells assessed as autophosporylated level by ELISA


Bioorg Med Chem Lett 25: 2527-31 (2015)

More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50384006
PNG
(CHEMBL2032274)
Show SMILES Nc1ncc(cc1-c1nc2ccc(O)cc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C20H20N6O2/c21-19-16(20-25-17-2-1-15(27)8-18(17)28-20)7-12(9-23-19)13-10-24-26(11-13)14-3-5-22-6-4-14/h1-2,7-11,14,22,27H,3-6H2,(H2,21,23)
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n/an/a 14n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of Ron


Bioorg Med Chem Lett 22: 4044-8 (2012)

More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50115203
PNG
(CHEMBL3608551)
Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4-c4cccnc4)-c4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C32H22FN7O2S/c1-39-18-26(36-19-39)29-15-25-31(43-29)28(11-13-35-25)42-27-10-9-21(14-24(27)33)38-32(41)23-17-37-40(22-7-3-2-4-8-22)30(23)20-6-5-12-34-16-20/h2-19H,1H3,(H,38,41)
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n/an/a 14n/an/an/an/an/an/a



Laboratoires ChemRF Inc./ChemRF Laboratories Inc.

Curated by ChEMBL


Assay Description
Inhibition of human RON


Bioorg Med Chem Lett 25: 3810-5 (2015)

More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50147893
PNG
(CHEMBL3764279)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)N\N=C\c4cccc(CC=C)c4O)cc3F)ccnc2cc1OCCCN1CCCCC1
Show InChI InChI=1S/C35H38FN5O5/c1-3-9-24-10-7-11-25(34(24)42)23-38-40-35(43)39-26-12-13-31(28(36)20-26)46-30-14-15-37-29-22-33(32(44-2)21-27(29)30)45-19-8-18-41-16-5-4-6-17-41/h3,7,10-15,20-23,42H,1,4-6,8-9,16-19H2,2H3,(H2,39,40,43)/b38-23+
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n/an/a 15n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Ron (unknown origin) using poly(glu,Tyr)4:1 as substrate incubated for 30 mins by homogeneous time-resolved fluorescence assay


Bioorg Med Chem 24: 1331-45 (2016)

More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50317324
PNG
(CHEMBL1087984 | N-(4-(6,7-dimethoxyquinolin-4-ylox...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2cc1OC
Show InChI InChI=1S/C28H20F4N4O4/c1-38-24-13-18-21(14-25(24)39-2)33-11-10-22(18)40-23-9-8-16(12-20(23)29)35-27(37)19-15-34-36(26(19)28(30,31)32)17-6-4-3-5-7-17/h3-15H,1-2H3,(H,35,37)
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n/an/a 16n/an/an/an/an/an/a



ChemRF Laboratories

Curated by ChEMBL


Assay Description
Inhibition of RON (unknown origin) transfected in 293T cells assessed as autophosporylated level by ELISA


Bioorg Med Chem Lett 25: 2527-31 (2015)

More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50090968
PNG
(CHEMBL3582035)
Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4nnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C27H17F4N7O2S/c1-37-13-19(33-14-37)22-12-18-24(41-22)21(9-10-32-18)40-20-8-7-15(11-17(20)28)34-26(39)23-25(27(29,30)31)38(36-35-23)16-5-3-2-4-6-16/h2-14H,1H3,(H,34,39)
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n/an/a 17n/an/an/an/an/an/a



ChemRF Laboratories

Curated by ChEMBL


Assay Description
Inhibition of RON (unknown origin) transfected in 293T cells assessed as autophosporylated level by ELISA


Bioorg Med Chem Lett 25: 2527-31 (2015)

More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50439772
PNG
(CHEMBL2419669)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)NN=Cc4ccc(F)cc4F)cc3F)ccnc2cc1OCCCN1CCC(C)CC1
Show InChI InChI=1S/C33H34F3N5O4/c1-21-9-13-41(14-10-21)12-3-15-44-32-19-28-25(18-31(32)43-2)29(8-11-37-28)45-30-7-6-24(17-27(30)36)39-33(42)40-38-20-22-4-5-23(34)16-26(22)35/h4-8,11,16-21H,3,9-10,12-15H2,1-2H3,(H2,39,40,42)
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n/an/a 19n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of RON (unknown origin) using poly(Glu,Tyr) as substrate after 30 mins by HTRF assay


Bioorg Med Chem 21: 5246-60 (2013)

More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50115201
PNG
(CHEMBL3608544)
Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4-c4ccccc4)-c4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C33H23FN6O2S/c1-39-19-27(36-20-39)30-17-26-32(43-30)29(14-15-35-26)42-28-13-12-22(16-25(28)34)38-33(41)24-18-37-40(23-10-6-3-7-11-23)31(24)21-8-4-2-5-9-21/h2-20H,1H3,(H,38,41)
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n/an/a 23n/an/an/an/an/an/a



Laboratoires ChemRF Inc./ChemRF Laboratories Inc.

Curated by ChEMBL


Assay Description
Inhibition of human RON


Bioorg Med Chem Lett 25: 3810-5 (2015)

More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50115196
PNG
(CHEMBL3608549)
Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4-c4ccccn4)-c4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C32H22FN7O2S/c1-39-18-26(36-19-39)29-16-25-31(43-29)28(12-14-35-25)42-27-11-10-20(15-23(27)33)38-32(41)22-17-37-40(21-7-3-2-4-8-21)30(22)24-9-5-6-13-34-24/h2-19H,1H3,(H,38,41)
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n/an/a 23n/an/an/an/an/an/a



Laboratoires ChemRF Inc./ChemRF Laboratories Inc.

Curated by ChEMBL


Assay Description
Inhibition of human RON


Bioorg Med Chem Lett 25: 3810-5 (2015)

More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50115197
PNG
(CHEMBL3608547)
Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4-c4ccccc4F)-c4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C33H22F2N6O2S/c1-40-18-27(37-19-40)30-16-26-32(44-30)29(13-14-36-26)43-28-12-11-20(15-25(28)35)39-33(42)23-17-38-41(21-7-3-2-4-8-21)31(23)22-9-5-6-10-24(22)34/h2-19H,1H3,(H,39,42)
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n/an/a 25n/an/an/an/an/an/a



Laboratoires ChemRF Inc./ChemRF Laboratories Inc.

Curated by ChEMBL


Assay Description
Inhibition of human RON


Bioorg Med Chem Lett 25: 3810-5 (2015)

More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50437161
PNG
(CHEMBL2401832)
Show SMILES C[C@@H](Oc1c(N)ncc2c(coc12)C1=CCN(CC1)C(N)=O)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H19Cl2FN4O3/c1-10(16-14(22)2-3-15(24)17(16)23)31-19-18-12(8-27-20(19)25)13(9-30-18)11-4-6-28(7-5-11)21(26)29/h2-4,8-10H,5-7H2,1H3,(H2,25,27)(H2,26,29)/t10-/m1/s1
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n/an/a 25n/an/an/an/an/an/a



OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of RON (unknown origin) autophosphorylation


Bioorg Med Chem Lett 23: 4381-7 (2013)

More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50115202
PNG
(CHEMBL3608550)
Show SMILES COc1cccc(c1)-c1c(cnn1-c1ccccc1)C(=O)Nc1ccc(Oc2ccnc3cc(sc23)-c2cn(C)cn2)c(F)c1
Show InChI InChI=1S/C34H25FN6O3S/c1-40-19-28(37-20-40)31-17-27-33(45-31)30(13-14-36-27)44-29-12-11-22(16-26(29)35)39-34(42)25-18-38-41(23-8-4-3-5-9-23)32(25)21-7-6-10-24(15-21)43-2/h3-20H,1-2H3,(H,39,42)
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n/an/a 27n/an/an/an/an/an/a



Laboratoires ChemRF Inc./ChemRF Laboratories Inc.

Curated by ChEMBL


Assay Description
Inhibition of human RON


Bioorg Med Chem Lett 25: 3810-5 (2015)

More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50102822
PNG
(CHEMBL3339360)
Show SMILES COc1cc2c(Oc3ccc(CC(=O)N\N=C\c4ccc(cc4)C(F)(F)F)cc3F)ccnc2cc1OCCCN1CCCC1
Show InChI InChI=1S/C33H32F4N4O4/c1-43-30-19-25-27(20-31(30)44-16-4-15-41-13-2-3-14-41)38-12-11-28(25)45-29-10-7-23(17-26(29)34)18-32(42)40-39-21-22-5-8-24(9-6-22)33(35,36)37/h5-12,17,19-21H,2-4,13-16,18H2,1H3,(H,40,42)/b39-21+
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n/an/a 29n/an/an/an/an/an/a



Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, 103 Wenhua Road, Shenhe District, PR China.

Curated by ChEMBL


Assay Description
Inhibition of RON (unknown origin)


Eur J Med Chem 87: 508-18 (2014)

More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50317338
PNG
(6-(7-(2-fluoro-4-(1-phenyl-5-(trifluoromethyl)-1H-...)
Show SMILES CN(C)C(=O)c1ccc(nc1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C32H22F4N6O3S/c1-41(2)31(44)18-8-10-23(38-16-18)27-15-24-28(46-27)26(12-13-37-24)45-25-11-9-19(14-22(25)33)40-30(43)21-17-39-42(29(21)32(34,35)36)20-6-4-3-5-7-20/h3-17H,1-2H3,(H,40,43)
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n/an/a 30n/an/an/an/an/an/a



MethylGene Inc.

Curated by ChEMBL


Assay Description
Inhibition of TPR-tagged RON catalytic domain expressed in HEK293 cells


Bioorg Med Chem Lett 20: 2745-9 (2010)

More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50317335
PNG
(CHEMBL1095356 | N-(4-(2-(4-(dimethylcarbamoyl)phen...)
Show SMILES CN(C)C(=O)c1ccc(cc1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C33H23F4N5O3S/c1-41(2)32(44)20-10-8-19(9-11-20)28-17-25-29(46-28)27(14-15-38-25)45-26-13-12-21(16-24(26)34)40-31(43)23-18-39-42(30(23)33(35,36)37)22-6-4-3-5-7-22/h3-18H,1-2H3,(H,40,43)
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n/an/a 30n/an/an/an/an/an/a



MethylGene Inc.

Curated by ChEMBL


Assay Description
Inhibition of TPR-tagged RON catalytic domain expressed in HEK293 cells


Bioorg Med Chem Lett 20: 2745-9 (2010)

More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM251929
PNG
(US9481668, A6)
Show SMILES CCc1c(cnn1-c1cncnc1)C(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)c(F)c1
Show InChI InChI=1S/C27H23FN6O4/c1-4-22-19(14-32-34(22)17-12-29-15-30-13-17)27(35)33-16-5-6-24(20(28)9-16)38-23-7-8-31-21-11-26(37-3)25(36-2)10-18(21)23/h5-15H,4H2,1-3H3,(H,33,35)
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n/an/a 30n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out as 384-well FlashPlate assay. As test plates 384-well streptavidine coated FlashPlate microtitre plates from Perkin ...


US Patent US9481668 (2016)

More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50317323
PNG
(CHEMBL1094718 | N-(3-fluoro-4-(2-(1-methyl-1H-imid...)
Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C28H18F4N6O2S/c1-37-14-21(34-15-37)24-12-20-25(41-24)23(9-10-33-20)40-22-8-7-16(11-19(22)29)36-27(39)18-13-35-38(26(18)28(30,31)32)17-5-3-2-4-6-17/h2-15H,1H3,(H,36,39)
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n/an/a 30n/an/an/an/an/an/a



ChemRF Laboratories

Curated by ChEMBL


Assay Description
Inhibition of RON phosphorylation in human HT29 cells


Bioorg Med Chem Lett 25: 2527-31 (2015)

More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50317323
PNG
(CHEMBL1094718 | N-(3-fluoro-4-(2-(1-methyl-1H-imid...)
Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C28H18F4N6O2S/c1-37-14-21(34-15-37)24-12-20-25(41-24)23(9-10-33-20)40-22-8-7-16(11-19(22)29)36-27(39)18-13-35-38(26(18)28(30,31)32)17-5-3-2-4-6-17/h2-15H,1H3,(H,36,39)
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n/an/a 30n/an/an/an/an/an/a



ChemRF Laboratories

Curated by ChEMBL


Assay Description
Inhibition of RON phosphorylation in human PC3 cells


Bioorg Med Chem Lett 25: 2527-31 (2015)

More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50114398
PNG
(CHEMBL3609808)
Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(cc3F)N3CCc4c(cnn4-c4ccccc4)C3=O)c2s1
Show InChI InChI=1S/C29H21FN6O2S/c1-34-16-23(32-17-34)27-14-22-28(39-27)26(9-11-31-22)38-25-8-7-19(13-21(25)30)35-12-10-24-20(29(35)37)15-33-36(24)18-5-3-2-4-6-18/h2-9,11,13-17H,10,12H2,1H3
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n/an/a 30n/an/an/an/an/an/a



Laboratoires ChemRF Inc. / ChemRF Laboratories Inc.

Curated by ChEMBL


Assay Description
Inhibition of human RON


Bioorg Med Chem Lett 25: 3706-10 (2015)

More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50115200
PNG
(CHEMBL3608545)
Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cn(nc4-c4ccccc4)-c4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C33H23FN6O2S/c1-39-19-27(36-20-39)30-17-26-32(43-30)29(14-15-35-26)42-28-13-12-22(16-25(28)34)37-33(41)24-18-40(23-10-6-3-7-11-23)38-31(24)21-8-4-2-5-9-21/h2-20H,1H3,(H,37,41)
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n/an/a 32n/an/an/an/an/an/a



Laboratoires ChemRF Inc./ChemRF Laboratories Inc.

Curated by ChEMBL


Assay Description
Inhibition of human RON


Bioorg Med Chem Lett 25: 3810-5 (2015)

More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50114396
PNG
(CHEMBL3609807)
Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(cc3F)N3CCCc4c(cnn4-c4ccccc4)C3=O)c2s1
Show InChI InChI=1S/C30H23FN6O2S/c1-35-17-24(33-18-35)28-15-23-29(40-28)27(11-12-32-23)39-26-10-9-20(14-22(26)31)36-13-5-8-25-21(30(36)38)16-34-37(25)19-6-3-2-4-7-19/h2-4,6-7,9-12,14-18H,5,8,13H2,1H3
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n/an/a 34n/an/an/an/an/an/a



Laboratoires ChemRF Inc. / ChemRF Laboratories Inc.

Curated by ChEMBL


Assay Description
Inhibition of human RON


Bioorg Med Chem Lett 25: 3706-10 (2015)

More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50317339
PNG
(6-(7-(2-fluoro-4-(1-phenyl-5-(trifluoromethyl)-1H-...)
Show SMILES COCCNC(=O)c1ccc(nc1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C33H24F4N6O4S/c1-46-14-13-39-31(44)19-7-9-24(40-17-19)28-16-25-29(48-28)27(11-12-38-25)47-26-10-8-20(15-23(26)34)42-32(45)22-18-41-43(30(22)33(35,36)37)21-5-3-2-4-6-21/h2-12,15-18H,13-14H2,1H3,(H,39,44)(H,42,45)
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n/an/a 40n/an/an/an/an/an/a



MethylGene Inc.

Curated by ChEMBL


Assay Description
Inhibition of TPR-tagged RON catalytic domain expressed in HEK293 cells


Bioorg Med Chem Lett 20: 2745-9 (2010)

More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50090966
PNG
(CHEMBL3582037)
Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccc(F)cc4)cc3F)c2s1
Show InChI InChI=1S/C28H17F5N6O2S/c1-38-13-21(35-14-38)24-11-20-25(42-24)23(8-9-34-20)41-22-7-4-16(10-19(22)30)37-27(40)18-12-36-39(26(18)28(31,32)33)17-5-2-15(29)3-6-17/h2-14H,1H3,(H,37,40)
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n/an/a 44n/an/an/an/an/an/a



ChemRF Laboratories

Curated by ChEMBL


Assay Description
Inhibition of RON (unknown origin) transfected in 293T cells assessed as autophosporylated level by ELISA


Bioorg Med Chem Lett 25: 2527-31 (2015)

More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50115199
PNG
(CHEMBL3608312)
Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4sc(nc4-c4ccccc4)-c4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C33H22FN5O2S2/c1-39-18-25(36-19-39)28-17-24-30(42-28)27(14-15-35-24)41-26-13-12-22(16-23(26)34)37-32(40)31-29(20-8-4-2-5-9-20)38-33(43-31)21-10-6-3-7-11-21/h2-19H,1H3,(H,37,40)
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n/an/a 45n/an/an/an/an/an/a



Laboratoires ChemRF Inc./ChemRF Laboratories Inc.

Curated by ChEMBL


Assay Description
Inhibition of human RON


Bioorg Med Chem Lett 25: 3810-5 (2015)

More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50114394
PNG
(CHEMBL3609805)
Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(cc3F)N3CC=Cc4c(cnn4-c4ccccc4)C3=O)c2s1
Show InChI InChI=1S/C30H21FN6O2S/c1-35-17-24(33-18-35)28-15-23-29(40-28)27(11-12-32-23)39-26-10-9-20(14-22(26)31)36-13-5-8-25-21(30(36)38)16-34-37(25)19-6-3-2-4-7-19/h2-12,14-18H,13H2,1H3
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n/an/a 49n/an/an/an/an/an/a



Laboratoires ChemRF Inc. / ChemRF Laboratories Inc.

Curated by ChEMBL


Assay Description
Inhibition of human RON


Bioorg Med Chem Lett 25: 3706-10 (2015)

More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50317323
PNG
(CHEMBL1094718 | N-(3-fluoro-4-(2-(1-methyl-1H-imid...)
Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C28H18F4N6O2S/c1-37-14-21(34-15-37)24-12-20-25(41-24)23(9-10-33-20)40-22-8-7-16(11-19(22)29)36-27(39)18-13-35-38(26(18)28(30,31)32)17-5-3-2-4-6-17/h2-15H,1H3,(H,36,39)
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n/an/a 50n/an/an/an/an/an/a



MethylGene Inc.

Curated by ChEMBL


Assay Description
Inhibition of TPR-tagged RON catalytic domain expressed in HEK293 cells


Bioorg Med Chem Lett 20: 2745-9 (2010)

More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50350069
PNG
(CHEMBL1813632)
Show SMILES Fc1ccc(cc1)-n1cccc(C(=O)Nc2ccc(Oc3ncnc4scc(-c5ccccc5)c34)c(F)c2)c1=O
Show InChI InChI=1S/C30H18F2N4O3S/c31-19-8-11-21(12-9-19)36-14-4-7-22(30(36)38)27(37)35-20-10-13-25(24(32)15-20)39-28-26-23(18-5-2-1-3-6-18)16-40-29(26)34-17-33-28/h1-17H,(H,35,37)
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n/an/a 50n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of RON


Bioorg Med Chem 19: 3906-18 (2011)

More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50317332
PNG
(CHEMBL1095034 | N-(3-fluoro-4-(2-(1-methyl-1H-imid...)
Show SMILES Cn1ccnc1-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C28H18F4N6O2S/c1-37-12-11-34-26(37)23-14-20-24(41-23)22(9-10-33-20)40-21-8-7-16(13-19(21)29)36-27(39)18-15-35-38(25(18)28(30,31)32)17-5-3-2-4-6-17/h2-15H,1H3,(H,36,39)
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n/an/a 60n/an/an/an/an/an/a



MethylGene Inc.

Curated by ChEMBL


Assay Description
Inhibition of TPR-tagged RON catalytic domain expressed in HEK293 cells


Bioorg Med Chem Lett 20: 2745-9 (2010)

More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50317333
PNG
((S)-N-(3-fluoro-4-(2-(4-((N-(1-methoxypropan-2-yl)...)
Show SMILES COC[C@H](C)N(Cc1ccc(cc1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1)C(C)=O
Show InChI InChI=1S/C37H31F4N5O4S/c1-22(21-49-3)45(23(2)47)20-24-9-11-25(12-10-24)33-18-30-34(51-33)32(15-16-42-30)50-31-14-13-26(17-29(31)38)44-36(48)28-19-43-46(35(28)37(39,40)41)27-7-5-4-6-8-27/h4-19,22H,20-21H2,1-3H3,(H,44,48)/t22-/m0/s1
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n/an/a 60n/an/an/an/an/an/a



MethylGene Inc.

Curated by ChEMBL


Assay Description
Inhibition of TPR-tagged RON catalytic domain expressed in HEK293 cells


Bioorg Med Chem Lett 20: 2745-9 (2010)

More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50242737
PNG
((R,Z)-5-(2,6-dichlorobenzylsulfonyl)-3-((3,5-dimet...)
Show SMILES Cc1[nH]c(\C=C2/C(=O)Nc3ccc(cc23)S(=O)(=O)Cc2c(Cl)cccc2Cl)c(C)c1C(=O)N1CCC[C@@H]1CN1CCCC1
Show InChI InChI=1S/C32H34Cl2N4O4S/c1-19-29(35-20(2)30(19)32(40)38-14-6-7-21(38)17-37-12-3-4-13-37)16-24-23-15-22(10-11-28(23)36-31(24)39)43(41,42)18-25-26(33)8-5-9-27(25)34/h5,8-11,15-16,21,35H,3-4,6-7,12-14,17-18H2,1-2H3,(H,36,39)/b24-16-/t21-/m1/s1
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n/an/a 68n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of Ron by cellular assay


Proc Natl Acad Sci USA 104: 19936-41 (2007)

More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50317324
PNG
(CHEMBL1087984 | N-(4-(6,7-dimethoxyquinolin-4-ylox...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2cc1OC
Show InChI InChI=1S/C28H20F4N4O4/c1-38-24-13-18-21(14-25(24)39-2)33-11-10-22(18)40-23-9-8-16(12-20(23)29)35-27(37)19-15-34-36(26(19)28(30,31)32)17-6-4-3-5-7-17/h3-15H,1-2H3,(H,35,37)
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n/an/a 80n/an/an/an/an/an/a



MethylGene Inc.

Curated by ChEMBL


Assay Description
Inhibition of TPR-tagged RON catalytic domain expressed in HEK293 cells


Bioorg Med Chem Lett 20: 2745-9 (2010)

More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Mus musculus)
BDBM50306682
PNG
((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Show SMILES C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1
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n/an/a 80n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of RON in mouse 3T3 cells assessed as growth factor-induced autophosphorylation by sandwich ELISA method


J Med Chem 54: 6342-63 (2011)

More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50317334
PNG
(CHEMBL1095036 | N-(3-fluoro-4-(2-(4-((2-(methylsul...)
Show SMILES CS(=O)(=O)CCNCc1ccc(cc1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C34H27F4N5O4S2/c1-49(45,46)16-15-39-19-21-7-9-22(10-8-21)30-18-27-31(48-30)29(13-14-40-27)47-28-12-11-23(17-26(28)35)42-33(44)25-20-41-43(32(25)34(36,37)38)24-5-3-2-4-6-24/h2-14,17-18,20,39H,15-16,19H2,1H3,(H,42,44)
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n/an/a 80n/an/an/an/an/an/a



MethylGene Inc.

Curated by ChEMBL


Assay Description
Inhibition of TPR-tagged RON catalytic domain expressed in HEK293 cells


Bioorg Med Chem Lett 20: 2745-9 (2010)

More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50317336
PNG
(CHEMBL1095357 | N-(4-(2-(4-((2-(dimethylamino)ethy...)
Show SMILES CN(C)CCN(C)C(=O)c1ccc(cc1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C36H30F4N6O3S/c1-44(2)17-18-45(3)35(48)23-11-9-22(10-12-23)31-20-28-32(50-31)30(15-16-41-28)49-29-14-13-24(19-27(29)37)43-34(47)26-21-42-46(33(26)36(38,39)40)25-7-5-4-6-8-25/h4-16,19-21H,17-18H2,1-3H3,(H,43,47)
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n/an/a 90n/an/an/an/an/an/a



MethylGene Inc.

Curated by ChEMBL


Assay Description
Inhibition of TPR-tagged RON catalytic domain expressed in HEK293 cells


Bioorg Med Chem Lett 20: 2745-9 (2010)

More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50317340
PNG
(CHEMBL1095361 | N-(4-(2-(1-acetyl-1,2,3,6-tetrahyd...)
Show SMILES CC(=O)N1CCC(=CC1)c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C31H23F4N5O3S/c1-18(41)39-13-10-19(11-14-39)27-16-24-28(44-27)26(9-12-36-24)43-25-8-7-20(15-23(25)32)38-30(42)22-17-37-40(29(22)31(33,34)35)21-5-3-2-4-6-21/h2-10,12,15-17H,11,13-14H2,1H3,(H,38,42)
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n/an/a 90n/an/an/an/an/an/a



MethylGene Inc.

Curated by ChEMBL


Assay Description
Inhibition of TPR-tagged RON catalytic domain expressed in HEK293 cells


Bioorg Med Chem Lett 20: 2745-9 (2010)

More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50187716
PNG
(CHEMBL3735648)
Show SMILES CC1(C)c2[nH]c3cc(ccc3c2C(=O)c2ccc(cc12)C1CCN(CC2CCOCC2)CC1)C#N
Show InChI InChI=1S/C30H33N3O2/c1-30(2)25-16-22(21-7-11-33(12-8-21)18-19-9-13-35-14-10-19)4-6-23(25)28(34)27-24-5-3-20(17-31)15-26(24)32-29(27)30/h3-6,15-16,19,21,32H,7-14,18H2,1-2H3
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n/an/a 93n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His6-tagged recombinant human Ron (983 residues) expressed in insect Sf21 cells using poly(Glu,Tyr)4:1 as substrate incubate...


Eur J Med Chem 118: 244-9 (2016)

More data for this
Ligand-Target Pair
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