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Compile Data Set for Download or QSAR

Found 5781 hits Enz. Inhib. hit(s) with Target = 'Mast/stem cell growth factor receptor Kit'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (Human))
BDBM50297394
PNG
(CHEMBL4171115)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)NN4C(SCC4=O)c4c(F)cccc4F)c(F)c3)ccnc2cc1OCCCN1CCCC1
Show InChI InChI=1S/C33H32F3N5O5S/c1-44-28-17-21-26(18-29(28)45-15-5-14-40-12-2-3-13-40)37-11-10-27(21)46-20-8-9-25(24(36)16-20)38-33(43)39-41-30(42)19-47-32(41)31-22(34)6-4-7-23(31)35/h4,6-11,16-18,32H,2-3,5,12-15,19H2,1H3,(H2,38,39,43)
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n/an/a 0.0290n/an/an/an/an/an/a



Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL


Assay Description
Inhibition of [125I]VCAM-Ig binding to VLA-4 of Jurkat cells in the presence of [Ca2+]


Eur J Med Chem 146: 368-380 (2018)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (Human))
BDBM50021574
PNG
(BMS-907351 | CABOZANTINIB | CHEBI:72317 | Cabomety...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3)c2cc1OC
Show InChI InChI=1S/C28H24FN3O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34)
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n/an/a 0.0530n/an/an/an/an/an/a



Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL


Assay Description
Inhibition of c-Kit (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 1 hr by ELISA


Eur J Med Chem 146: 368-380 (2018)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM139540
PNG
(US10189849, staurosporine | US10307427, Staurospor...)
Show SMILES CN[C@@H]1CC2OC([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1/C27H24N4O3/c1-28-16-11-19-30-17-9-5-4-8-14(17)21-22-15(12-29-26(22)32)20-13-7-3-6-10-18(13)31(23(20)24(21)30)27(34-19)25(16)33-2/h3-10,16,19,25,27-28H,11-12H2,1-2H3,(H,29,32)/t16-,19?,25-,27?/s2
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US Patent
n/an/a 0.180n/an/an/an/an/an/a



Temple University

US Patent


Assay Description
The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...


US Patent US8889696 (2014)


BindingDB Entry DOI: 10.7270/Q2930RVR
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM397923
PNG
(US9994552, Compound 134)
Show SMILES COc1cc2c(ncnc2cc1OCCCN1CCN(C)CC1)N1CCN(CC1)c1ncc(Cc2ccccc2)cn1
Show InChI InChI=1S/C32H40N8O2/c1-37-10-12-38(13-11-37)9-6-18-42-30-21-28-27(20-29(30)41-2)31(36-24-35-28)39-14-16-40(17-15-39)32-33-22-26(23-34-32)19-25-7-4-3-5-8-25/h3-5,7-8,20-24H,6,9-19H2,1-2H3
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...


US Patent US9994552 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM397923
PNG
(US9994552, Compound 134)
Show SMILES COc1cc2c(ncnc2cc1OCCCN1CCN(C)CC1)N1CCN(CC1)c1ncc(Cc2ccccc2)cn1
Show InChI InChI=1S/C32H40N8O2/c1-37-10-12-38(13-11-37)9-6-18-42-30-21-28-27(20-29(30)41-2)31(36-24-35-28)39-14-16-40(17-15-39)32-33-22-26(23-34-32)19-25-7-4-3-5-8-25/h3-5,7-8,20-24H,6,9-19H2,1-2H3
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
Kit D816V assay: In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of ...


US Patent US9994552 (2018)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM397924
PNG
(US9994552, Compound 135)
Show SMILES CCOc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(N)n3)c2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C32H40N8O2/c1-3-41-29-19-27-26(18-28(29)42-21-24-9-11-38(2)12-10-24)31(36-22-35-27)39-13-15-40(16-14-39)32-34-20-25(30(33)37-32)17-23-7-5-4-6-8-23/h4-8,18-20,22,24H,3,9-17,21H2,1-2H3,(H2,33,34,37)
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...


US Patent US9994552 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM397924
PNG
(US9994552, Compound 135)
Show SMILES CCOc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(N)n3)c2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C32H40N8O2/c1-3-41-29-19-27-26(18-28(29)42-21-24-9-11-38(2)12-10-24)31(36-22-35-27)39-13-15-40(16-14-39)32-34-20-25(30(33)37-32)17-23-7-5-4-6-8-23/h4-8,18-20,22,24H,3,9-17,21H2,1-2H3,(H2,33,34,37)
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
Kit D816V assay: In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of ...


US Patent US9994552 (2018)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM397925
PNG
(US9994552, Compound 136)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCCCN1CCN(C)CC1
Show InChI InChI=1S/C32H40N8O2/c1-37-10-12-38(13-11-37)9-6-18-42-30-20-27-28(21-29(30)41-2)35-24-36-31(27)39-14-16-40(17-15-39)32-33-22-26(23-34-32)19-25-7-4-3-5-8-25/h3-5,7-8,20-24H,6,9-19H2,1-2H3
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...


US Patent US9994552 (2018)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM397927
PNG
(US9994552, Compound 138)
Show SMILES CCOc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(=O)[nH]3)c2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C32H39N7O3/c1-3-41-29-19-27-26(18-28(29)42-21-24-9-11-37(2)12-10-24)30(35-22-34-27)38-13-15-39(16-14-38)32-33-20-25(31(40)36-32)17-23-7-5-4-6-8-23/h4-8,18-20,22,24H,3,9-17,21H2,1-2H3,(H,33,36,40)
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...


US Patent US9994552 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM397927
PNG
(US9994552, Compound 138)
Show SMILES CCOc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(=O)[nH]3)c2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C32H39N7O3/c1-3-41-29-19-27-26(18-28(29)42-21-24-9-11-37(2)12-10-24)30(35-22-34-27)38-13-15-39(16-14-38)32-33-20-25(31(40)36-32)17-23-7-5-4-6-8-23/h4-8,18-20,22,24H,3,9-17,21H2,1-2H3,(H,33,36,40)
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
Kit D816V assay: In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of ...


US Patent US9994552 (2018)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM397893
PNG
(US9994552, Compound 104)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OC[C@H]1CNCCO1
Show InChI InChI=1S/C29H33N7O3/c1-37-26-15-25-24(14-27(26)39-19-23-18-30-7-12-38-23)28(34-20-33-25)35-8-10-36(11-9-35)29-31-16-22(17-32-29)13-21-5-3-2-4-6-21/h2-6,14-17,20,23,30H,7-13,18-19H2,1H3/t23-/m1/s1
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...


US Patent US9994552 (2018)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM397894
PNG
(US9994552, Compound 105)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCC1CNCCO1
Show InChI InChI=1S/C29H33N7O3/c1-37-26-15-25-24(14-27(26)39-19-23-18-30-7-12-38-23)28(34-20-33-25)35-8-10-36(11-9-35)29-31-16-22(17-32-29)13-21-5-3-2-4-6-21/h2-6,14-17,20,23,30H,7-13,18-19H2,1H3
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...


US Patent US9994552 (2018)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM397897
PNG
(US9994552, Compound 108)
Show SMILES COCCOc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCCOC
Show InChI InChI=1S/C29H34N6O4/c1-36-12-14-38-26-17-24-25(18-27(26)39-15-13-37-2)32-21-33-28(24)34-8-10-35(11-9-34)29-30-19-23(20-31-29)16-22-6-4-3-5-7-22/h3-7,17-21H,8-16H2,1-2H3
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...


US Patent US9994552 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM397897
PNG
(US9994552, Compound 108)
Show SMILES COCCOc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCCOC
Show InChI InChI=1S/C29H34N6O4/c1-36-12-14-38-26-17-24-25(18-27(26)39-15-13-37-2)32-21-33-28(24)34-8-10-35(11-9-34)29-30-19-23(20-31-29)16-22-6-4-3-5-7-22/h3-7,17-21H,8-16H2,1-2H3
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
Kit D816V assay: In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of ...


US Patent US9994552 (2018)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM397898
PNG
(US9994552, Compound 109)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCC1CCNC(=O)C1
Show InChI InChI=1S/C30H33N7O3/c1-39-26-16-25-24(15-27(26)40-19-22-7-8-31-28(38)14-22)29(35-20-34-25)36-9-11-37(12-10-36)30-32-17-23(18-33-30)13-21-5-3-2-4-6-21/h2-6,15-18,20,22H,7-14,19H2,1H3,(H,31,38)
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...


US Patent US9994552 (2018)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM397899
PNG
(US9994552, Compound 110)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCCN1CCCC1=O
Show InChI InChI=1S/C30H33N7O3/c1-39-26-18-25-24(17-27(26)40-15-14-35-9-5-8-28(35)38)29(34-21-33-25)36-10-12-37(13-11-36)30-31-19-23(20-32-30)16-22-6-3-2-4-7-22/h2-4,6-7,17-21H,5,8-16H2,1H3
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...


US Patent US9994552 (2018)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM397900
PNG
(US9994552, Compound 111)
Show SMILES COc1cc2c(ncnc2cc1OCCN1CCCC1=O)N1CCN(CC1)c1ncc(Cc2ccccc2)cn1
Show InChI InChI=1S/C30H33N7O3/c1-39-26-17-24-25(18-27(26)40-15-14-35-9-5-8-28(35)38)33-21-34-29(24)36-10-12-37(13-11-36)30-31-19-23(20-32-30)16-22-6-3-2-4-7-22/h2-4,6-7,17-21H,5,8-16H2,1H3
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...


US Patent US9994552 (2018)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM397901
PNG
(US9994552, Compound 112)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C31H37N7O2/c1-36-10-8-24(9-11-36)21-40-29-17-26-27(18-28(29)39-2)34-22-35-30(26)37-12-14-38(15-13-37)31-32-19-25(20-33-31)16-23-6-4-3-5-7-23/h3-7,17-20,22,24H,8-16,21H2,1-2H3
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...


US Patent US9994552 (2018)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM397902
PNG
(US9994552, Compound 113)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OC[C@@H]1CCCN(C)C1
Show InChI InChI=1S/C31H37N7O2/c1-36-10-6-9-24(20-36)21-40-29-16-26-27(17-28(29)39-2)34-22-35-30(26)37-11-13-38(14-12-37)31-32-18-25(19-33-31)15-23-7-4-3-5-8-23/h3-5,7-8,16-19,22,24H,6,9-15,20-21H2,1-2H3/t24-/m1/s1
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...


US Patent US9994552 (2018)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM397903
PNG
(US9994552, Compound 114)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCC1CCCN(C)C1
Show InChI InChI=1S/C31H37N7O2/c1-36-10-6-9-24(20-36)21-40-29-16-26-27(17-28(29)39-2)34-22-35-30(26)37-11-13-38(14-12-37)31-32-18-25(19-33-31)15-23-7-4-3-5-8-23/h3-5,7-8,16-19,22,24H,6,9-15,20-21H2,1-2H3
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...


US Patent US9994552 (2018)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM397906
PNG
(US9994552, Compound 117)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCC1CN(C)CCO1
Show InChI InChI=1S/C30H35N7O3/c1-35-12-13-39-24(19-35)20-40-28-15-25-26(16-27(28)38-2)33-21-34-29(25)36-8-10-37(11-9-36)30-31-17-23(18-32-30)14-22-6-4-3-5-7-22/h3-7,15-18,21,24H,8-14,19-20H2,1-2H3
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...


US Patent US9994552 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175760
PNG
(US9688680, 305)
Show SMILES CC[C@H](NC(=O)C1CN(C1)c1ncnn2cc(cc12)-c1ccc(cc1)S(C)(=O)=O)c1ccc(Cl)cc1
Show InChI InChI=1/C26H26ClN5O3S/c1-3-23(18-4-8-21(27)9-5-18)30-26(33)20-13-31(14-20)25-24-12-19(15-32(24)29-16-28-25)17-6-10-22(11-7-17)36(2,34)35/h4-12,15-16,20,23H,3,13-14H2,1-2H3,(H,30,33)/t23-/s2
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175763
PNG
(US9688680, 308)
Show SMILES CC1(CN(C1)c1ncnn2cc(cc12)-c1ccc(cc1)S(C)(=O)=O)C(=O)NCc1ccc(Cl)cc1F
Show InChI InChI=1S/C25H23ClFN5O3S/c1-25(24(33)28-11-17-3-6-19(26)10-21(17)27)13-31(14-25)23-22-9-18(12-32(22)30-15-29-23)16-4-7-20(8-5-16)36(2,34)35/h3-10,12,15H,11,13-14H2,1-2H3,(H,28,33)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175764
PNG
(US9688680, 309)
Show SMILES CC[C@H](NC(=O)C1CN(C1)c1ncnn2cc(cc12)C1=CCN(CC1)S(C)(=O)=O)c1ccc(Cl)cc1
Show InChI InChI=1/C25H29ClN6O3S/c1-3-22(18-4-6-21(26)7-5-18)29-25(33)20-13-30(14-20)24-23-12-19(15-32(23)28-16-27-24)17-8-10-31(11-9-17)36(2,34)35/h4-8,12,15-16,20,22H,3,9-11,13-14H2,1-2H3,(H,29,33)/t22-/s2
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175766
PNG
(US9688680, 311)
Show SMILES CCC(=O)N1CCC(=CC1)c1cc2c(ncnn2c1)N1CC(C)(C1)C(=O)N[C@@H](CCO)c1ccc(Cl)cc1
Show InChI InChI=1/C28H33ClN6O3/c1-3-25(37)33-11-8-19(9-12-33)21-14-24-26(30-18-31-35(24)15-21)34-16-28(2,17-34)27(38)32-23(10-13-36)20-4-6-22(29)7-5-20/h4-8,14-15,18,23,36H,3,9-13,16-17H2,1-2H3,(H,32,38)/t23-/s2
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175705
PNG
(US9688680, 250)
Show SMILES C[C@H](NC(=O)C1CN(C1)c1ncnn2cc(cc12)-c1cnn(CC(C)(C)O)c1)c1ccc(Cl)cc1
Show InChI InChI=1/C25H28ClN7O2/c1-16(17-4-6-21(26)7-5-17)30-24(34)20-10-31(11-20)23-22-8-18(13-33(22)29-15-27-23)19-9-28-32(12-19)14-25(2,3)35/h4-9,12-13,15-16,20,35H,10-11,14H2,1-3H3,(H,30,34)/t16-/s2
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175706
PNG
(US9688680, 251)
Show SMILES CC[C@H](NC(=O)C1CN(C1)c1ncnn2cc(cc12)-c1cnn(C[C@@H](C)O)c1)c1ccc(Cl)cc1
Show InChI InChI=1/C25H28ClN7O2/c1-3-22(17-4-6-21(26)7-5-17)30-25(35)20-11-31(12-20)24-23-8-18(14-33(23)29-15-27-24)19-9-28-32(13-19)10-16(2)34/h4-9,13-16,20,22,34H,3,10-12H2,1-2H3,(H,30,35)/t16-,22+/s2
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175707
PNG
(US9688680, 252)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2ccc(cc2)C(=O)N2CCCC2)cc1
Show InChI InChI=1S/C29H30N6O2/c1-20-4-6-21(7-5-20)15-30-28(36)25-16-34(17-25)27-26-14-24(18-35(26)32-19-31-27)22-8-10-23(11-9-22)29(37)33-12-2-3-13-33/h4-11,14,18-19,25H,2-3,12-13,15-17H2,1H3,(H,30,36)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175708
PNG
(US9688680, 253)
Show SMILES Cc1ccc(CNC(=O)C2(C)CN(C2)c2ncnn3cc(cc23)-c2ccc(cc2)C(=O)N2CCC2)cc1
Show InChI InChI=1S/C29H30N6O2/c1-20-4-6-21(7-5-20)15-30-28(37)29(2)17-34(18-29)26-25-14-24(16-35(25)32-19-31-26)22-8-10-23(11-9-22)27(36)33-12-3-13-33/h4-11,14,16,19H,3,12-13,15,17-18H2,1-2H3,(H,30,37)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175709
PNG
(US9688680, 254)
Show SMILES Cc1ccc(CNC(=O)C2(C)CN(C2)c2ncnn3cc(cc23)-c2ccc(cc2)N2CCCC2=O)cc1
Show InChI InChI=1S/C29H30N6O2/c1-20-5-7-21(8-6-20)15-30-28(37)29(2)17-33(18-29)27-25-14-23(16-35(25)32-19-31-27)22-9-11-24(12-10-22)34-13-3-4-26(34)36/h5-12,14,16,19H,3-4,13,15,17-18H2,1-2H3,(H,30,37)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175710
PNG
(US9688680, 255)
Show SMILES COC(=O)N1CCC(=CC1)c1cc2c(ncnn2c1)N1CC(C)(C1)C(=O)NCc1ccc(Cl)cc1
Show InChI InChI=1S/C25H27ClN6O3/c1-25(23(33)27-12-17-3-5-20(26)6-4-17)14-31(15-25)22-21-11-19(13-32(21)29-16-28-22)18-7-9-30(10-8-18)24(34)35-2/h3-7,11,13,16H,8-10,12,14-15H2,1-2H3,(H,27,33)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175714
PNG
(US9688680, 259)
Show SMILES CC(C)(O)Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CC(C1)C(=O)NCc1ccc(Cl)cc1F
Show InChI InChI=1S/C24H25ClFN7O2/c1-24(2,35)13-32-11-17(8-29-32)16-5-21-22(28-14-30-33(21)12-16)31-9-18(10-31)23(34)27-7-15-3-4-19(25)6-20(15)26/h3-6,8,11-12,14,18,35H,7,9-10,13H2,1-2H3,(H,27,34)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175718
PNG
(US9688680, 263)
Show SMILES COC(=O)N1CCC(=CC1)c1cc2c(ncnn2c1)N1CC(C1)C(=O)NCc1ccc(Cl)cc1F
Show InChI InChI=1S/C24H24ClFN6O3/c1-35-24(34)30-6-4-15(5-7-30)17-8-21-22(28-14-29-32(21)13-17)31-11-18(12-31)23(33)27-10-16-2-3-19(25)9-20(16)26/h2-4,8-9,13-14,18H,5-7,10-12H2,1H3,(H,27,33)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175720
PNG
(US9688680, 265)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)C2=CCN(CC2)C(=O)N2CCCC2)cc1
Show InChI InChI=1S/C28H33N7O2/c1-20-4-6-21(7-5-20)15-29-27(36)24-16-34(17-24)26-25-14-23(18-35(25)31-19-30-26)22-8-12-33(13-9-22)28(37)32-10-2-3-11-32/h4-8,14,18-19,24H,2-3,9-13,15-17H2,1H3,(H,29,36)
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BLUEPRINT MEDICINES CORPORATION

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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175722
PNG
(US9688680, 267)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)C2=CCN(CC2)C(=O)OC(C)(C)C)cc1
Show InChI InChI=1S/C28H34N6O3/c1-19-5-7-20(8-6-19)14-29-26(35)23-15-33(16-23)25-24-13-22(17-34(24)31-18-30-25)21-9-11-32(12-10-21)27(36)37-28(2,3)4/h5-9,13,17-18,23H,10-12,14-16H2,1-4H3,(H,29,35)
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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175730
PNG
(US9688680, 275)
Show SMILES CC[C@H](NC(=O)C1CN(C1)c1ncnn2cc(cc12)-c1ccc(cc1)[C@@H](O)CO)c1ccc(Cl)cc1
Show InChI InChI=1/C27H28ClN5O3/c1-2-23(18-7-9-22(28)10-8-18)31-27(36)21-12-32(13-21)26-24-11-20(14-33(24)30-16-29-26)17-3-5-19(6-4-17)25(35)15-34/h3-11,14,16,21,23,25,34-35H,2,12-13,15H2,1H3,(H,31,36)/t23-,25-/s2
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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175733
PNG
(US9688680, 278)
Show SMILES CC[C@H](NC(=O)C1CN(C1)c1ncnn2cc(cc12)-c1cnn(CC(C)(C)N)c1)c1ccc(Cl)cc1
Show InChI InChI=1/C26H31ClN8O/c1-4-22(17-5-7-21(27)8-6-17)32-25(36)20-11-33(12-20)24-23-9-18(14-35(23)31-16-29-24)19-10-30-34(13-19)15-26(2,3)28/h5-10,13-14,16,20,22H,4,11-12,15,28H2,1-3H3,(H,32,36)/t22-/s2
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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175735
PNG
(US9688680, 280)
Show SMILES CC(C)(O)c1ccc(cc1)-c1cc2c(ncnn2c1)N1CC(C)(C1)C(=O)NCc1ccc(Cl)cc1F
Show InChI InChI=1S/C27H27ClFN5O2/c1-26(2,36)20-7-4-17(5-8-20)19-10-23-24(31-16-32-34(23)13-19)33-14-27(3,15-33)25(35)30-12-18-6-9-21(28)11-22(18)29/h4-11,13,16,36H,12,14-15H2,1-3H3,(H,30,35)
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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175673
PNG
(US9688680, 218)
Show SMILES CN(C)C(=O)c1ccc(cc1)-c1cc2c(ncnn2c1)N1CC(C1)C(=O)N[C@@H](CO)c1ccccc1
Show InChI InChI=1/C27H28N6O3/c1-31(2)27(36)20-10-8-18(9-11-20)21-12-24-25(28-17-29-33(24)15-21)32-13-22(14-32)26(35)30-23(16-34)19-6-4-3-5-7-19/h3-12,15,17,22-23,34H,13-14,16H2,1-2H3,(H,30,35)/t23-/s2
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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175674
PNG
(US9688680, 219)
Show SMILES CN(C)C(=O)c1ccc(cc1)-c1cc2c(ncnn2c1)N1CC(C1)C(=O)N[C@H](CO)c1ccccc1
Show InChI InChI=1/C27H28N6O3/c1-31(2)27(36)20-10-8-18(9-11-20)21-12-24-25(28-17-29-33(24)15-21)32-13-22(14-32)26(35)30-23(16-34)19-6-4-3-5-7-19/h3-12,15,17,22-23,34H,13-14,16H2,1-2H3,(H,30,35)/t23-/s2
PDB

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n/an/a<1n/an/an/an/a7.525



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175675
PNG
(US9688680, 220)
Show SMILES C[C@H](NC(=O)C1CN(C1)c1ncnn2cc(cc12)-c1ccc(cc1)C1(O)CCC1)c1ccc(F)cc1
Show InChI InChI=1/C28H28FN5O2/c1-18(19-5-9-24(29)10-6-19)32-27(35)22-14-33(15-22)26-25-13-21(16-34(25)31-17-30-26)20-3-7-23(8-4-20)28(36)11-2-12-28/h3-10,13,16-18,22,36H,2,11-12,14-15H2,1H3,(H,32,35)/t18-/s2
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n/an/a<1n/an/an/an/a7.525



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175677
PNG
(US9688680, 222)
Show SMILES COC1(CN(C1)c1ncnn2cc(cc12)-c1ccc(cc1)C(C)(C)O)C(=O)NCc1ccc(C)cc1
Show InChI InChI=1S/C28H31N5O3/c1-19-5-7-20(8-6-19)14-29-26(34)28(36-4)16-32(17-28)25-24-13-22(15-33(24)31-18-30-25)21-9-11-23(12-10-21)27(2,3)35/h5-13,15,18,35H,14,16-17H2,1-4H3,(H,29,34)
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n/an/a<1n/an/an/an/a7.525



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175678
PNG
(US9688680, 223)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2cnn(C[C@@H]3CNCCO3)c2)cc1
Show InChI InChI=1/C26H30N8O2/c1-18-2-4-19(5-3-18)9-28-26(35)22-12-32(13-22)25-24-8-20(15-34(24)31-17-29-25)21-10-30-33(14-21)16-23-11-27-6-7-36-23/h2-5,8,10,14-15,17,22-23,27H,6-7,9,11-13,16H2,1H3,(H,28,35)/t23-/s2
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n/an/a<1n/an/an/an/a7.525



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175679
PNG
(US9688680, 224)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)C2=CCN(CC2)C(=O)C(C)(C)C)cc1
Show InChI InChI=1S/C28H34N6O2/c1-19-5-7-20(8-6-19)14-29-26(35)23-15-33(16-23)25-24-13-22(17-34(24)31-18-30-25)21-9-11-32(12-10-21)27(36)28(2,3)4/h5-9,13,17-18,23H,10-12,14-16H2,1-4H3,(H,29,35)
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n/an/a<1n/an/an/an/a7.525



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175737
PNG
(US9688680, 282)
Show SMILES CC[C@H](O)Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CC(C1)C(=O)N[C@@H](CC)c1ccc(Cl)cc1
Show InChI InChI=1/C26H30ClN7O2/c1-3-22(35)15-33-13-19(10-29-33)18-9-24-25(28-16-30-34(24)14-18)32-11-20(12-32)26(36)31-23(4-2)17-5-7-21(27)8-6-17/h5-10,13-14,16,20,22-23,35H,3-4,11-12,15H2,1-2H3,(H,31,36)/t22-,23-/s2
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n/an/a<1n/an/an/an/a7.525



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175739
PNG
(US9688680, 284)
Show SMILES CC[C@H](NC(=O)C1CN(C1)c1ncnn2cc(cc12)-c1cnn(c1)[C@H](C)[C@H](C)O)c1ccc(Cl)cc1
Show InChI InChI=1/C26H30ClN7O2/c1-4-23(18-5-7-22(27)8-6-18)31-26(36)21-11-32(12-21)25-24-9-19(13-34(24)30-15-28-25)20-10-29-33(14-20)16(2)17(3)35/h5-10,13-17,21,23,35H,4,11-12H2,1-3H3,(H,31,36)/t16-,17+,23+/s2
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n/an/a<1n/an/an/an/a7.525



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175740
PNG
(US9688680, 285)
Show SMILES CC[C@H](NC(=O)C1CN(C1)c1ncnn2cc(cc12)-c1cnn(c1)[C@@H](C)[C@@H](C)O)c1ccc(Cl)cc1
Show InChI InChI=1/C26H30ClN7O2/c1-4-23(18-5-7-22(27)8-6-18)31-26(36)21-11-32(12-21)25-24-9-19(13-34(24)30-15-28-25)20-10-29-33(14-20)16(2)17(3)35/h5-10,13-17,21,23,35H,4,11-12H2,1-3H3,(H,31,36)/t16-,17+,23-/s2
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n/an/a<1n/an/an/an/a7.525



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175741
PNG
(US9688680, 286)
Show SMILES CC[C@H](NC(=O)C1CN(C1)c1ncnn2cc(cc12)C1=CCN(CC1)C(=O)OC)c1ccc(Cl)cc1
Show InChI InChI=1/C26H29ClN6O3/c1-3-22(18-4-6-21(27)7-5-18)30-25(34)20-13-32(14-20)24-23-12-19(15-33(23)29-16-28-24)17-8-10-31(11-9-17)26(35)36-2/h4-8,12,15-16,20,22H,3,9-11,13-14H2,1-2H3,(H,30,34)/t22-/s2
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n/an/a<1n/an/an/an/a7.525



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175742
PNG
(US9688680, 287)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2ccc(cc2)C(C)(O)C(F)(F)F)cc1
Show InChI InChI=1/C27H26F3N5O2/c1-17-3-5-18(6-4-17)12-31-25(36)21-13-34(14-21)24-23-11-20(15-35(23)33-16-32-24)19-7-9-22(10-8-19)26(2,37)27(28,29)30/h3-11,15-16,21,37H,12-14H2,1-2H3,(H,31,36)
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n/an/a<1n/an/an/an/a7.525



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175743
PNG
(US9688680, 288)
Show SMILES CC(C)(O)c1ccc(cc1)-c1cc2c(ncnn2c1)N1CC(C1)NC(=O)Cc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C26H25Cl2N5O2/c1-26(2,35)19-6-3-16(4-7-19)18-9-23-25(29-15-30-33(23)12-18)32-13-21(14-32)31-24(34)10-17-5-8-20(27)11-22(17)28/h3-9,11-12,15,21,35H,10,13-14H2,1-2H3,(H,31,34)
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n/an/a<1n/an/an/an/a7.525



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
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