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Compile Data Set for Download or QSAR

Found 2219 hits Enz. Inhib. hit(s) with Target = 'Mast/stem cell growth factor receptor Kit'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (human))
BDBM139540
PNG
(US8889696, Staurosporine | US9051313, Staurosporin...)
Show SMILES CN[C@@H]1CC2OC([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1/C27H24N4O3/c1-28-16-11-19-30-17-9-5-4-8-14(17)21-22-15(12-29-26(22)32)20-13-7-3-6-10-18(13)31(23(20)24(21)30)27(34-19)25(16)33-2/h3-10,16,19,25,27-28H,11-12H2,1-2H3,(H,29,32)/t16-,19?,25-,27?/s2
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US Patent
n/an/a 0.180n/an/an/an/an/an/a



Temple University—Of The Commonwealth System Of Higher Education

US Patent


Assay Description
The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...


US Patent US8889696 (2014)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (human))
BDBM50129829
PNG
(CHEMBL3628797)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Nc3ncnc4ccccc34)cc2)c1
Show InChI InChI=1S/C21H16BrN5O/c22-14-4-3-5-17(12-14)27-21(28)26-16-10-8-15(9-11-16)25-20-18-6-1-2-7-19(18)23-13-24-20/h1-13H,(H,23,24,25)(H2,26,27,28)
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n/an/a 1n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of c-Kit (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a>1n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of Kit


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (human))
BDBM50129830
PNG
(CHEMBL3628798)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Nc3ncnc4sccc34)cc2)c1
Show InChI InChI=1S/C19H14BrN5OS/c20-12-2-1-3-15(10-12)25-19(26)24-14-6-4-13(5-7-14)23-17-16-8-9-27-18(16)22-11-21-17/h1-11H,(H,21,22,23)(H2,24,25,26)
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n/an/a 1n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of c-Kit (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (human))
BDBM50215791
PNG
(2-((2-acetamidopyridin-4-yl)methylamino)-N-(2,2-di...)
Show SMILES CC(=O)Nc1cc(CNc2ccccc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)ccn1
Show InChI InChI=1S/C22H18F2N4O4/c1-13(29)27-20-10-14(8-9-25-20)12-26-17-5-3-2-4-16(17)21(30)28-15-6-7-18-19(11-15)32-22(23,24)31-18/h2-11,26H,12H2,1H3,(H,28,30)(H,25,27,29)
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n/an/a 1n/an/an/an/an/an/a



Bayer Research Center

Curated by ChEMBL


Assay Description
Inhibition of human recombinant cKit by FRET assay


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (human))
BDBM50215758
PNG
(2-((2-aminopyridin-4-yl)methylamino)-N-(2,2-difluo...)
Show SMILES Nc1cc(CNc2ccccc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)ccn1
Show InChI InChI=1S/C20H16F2N4O3/c21-20(22)28-16-6-5-13(10-17(16)29-20)26-19(27)14-3-1-2-4-15(14)25-11-12-7-8-24-18(23)9-12/h1-10,25H,11H2,(H2,23,24)(H,26,27)
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n/an/a 1n/an/an/an/an/an/a



Bayer Research Center

Curated by ChEMBL


Assay Description
Inhibition of human recombinant cKit by FRET assay


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (human))
BDBM50329427
PNG
(5-(2-Amino-pyrimidin-4-yl)-2-phenyl-1H-pyrrole-3-c...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccccc1)-c1ccnc(N)n1
Show InChI InChI=1S/C15H13N5O/c16-14(21)10-8-12(11-6-7-18-15(17)20-11)19-13(10)9-4-2-1-3-5-9/h1-8,19H,(H2,16,21)(H2,17,18,20)
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n/an/a>1n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of KIT


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (human))
BDBM50331026
PNG
((Z)-2-(5-Fluoro-2-oxo-1,2-dihydro-indol-3-ylidenem...)
Show SMILES CN(C)CCN1CCc2[nH]c(\C=C3/C(=O)Nc4ccc(F)cc34)c(C)c2C1=O
Show InChI InChI=1S/C21H23FN4O2/c1-12-18(11-15-14-10-13(22)4-5-16(14)24-20(15)27)23-17-6-7-26(9-8-25(2)3)21(28)19(12)17/h4-5,10-11,23H,6-9H2,1-3H3,(H,24,27)/b15-11-
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n/an/a 1n/an/an/an/an/an/a



Shanghai Hengrui Pharmaceuticals Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of c-Kit after 30 mins by ELISA


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (human))
BDBM50331028
PNG
((Z)-2-(5-Fluoro-2-oxo-1,2-dihydro-indol-3-ylidenem...)
Show SMILES Cc1c(\C=C2/C(=O)Nc3ccc(F)cc23)[nH]c2CCN(CCN3CCOCC3)C(=O)c12
Show InChI InChI=1S/C23H25FN4O3/c1-14-20(13-17-16-12-15(24)2-3-18(16)26-22(17)29)25-19-4-5-28(23(30)21(14)19)7-6-27-8-10-31-11-9-27/h2-3,12-13,25H,4-11H2,1H3,(H,26,29)/b17-13-
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n/an/a 1n/an/an/an/an/an/a



Shanghai Hengrui Pharmaceuticals Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of c-Kit after 30 mins by ELISA


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (human))
BDBM50331029
PNG
((R,Z)-2-(5-Fluoro-2-oxo-1,2-dihydro-indol-3-yliden...)
Show SMILES Cc1c(\C=C2/C(=O)Nc3ccc(F)cc23)[nH]c2CCN(C[C@H](O)CN3CCOCC3)C(=O)c12
Show InChI InChI=1S/C24H27FN4O4/c1-14-21(11-18-17-10-15(25)2-3-19(17)27-23(18)31)26-20-4-5-29(24(32)22(14)20)13-16(30)12-28-6-8-33-9-7-28/h2-3,10-11,16,26,30H,4-9,12-13H2,1H3,(H,27,31)/b18-11-/t16-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



Shanghai Hengrui Pharmaceuticals Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of c-Kit after 30 mins by ELISA


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (human))
BDBM50260888
PNG
(3-(2-aminoquinazolin-6-yl)-1-(2-cyclopentylethyl)-...)
Show SMILES Cc1ccn(CCC2CCCC2)c(=O)c1-c1ccc2nc(N)ncc2c1
Show InChI InChI=1S/C21H24N4O/c1-14-8-10-25(11-9-15-4-2-3-5-15)20(26)19(14)16-6-7-18-17(12-16)13-23-21(22)24-18/h6-8,10,12-13,15H,2-5,9,11H2,1H3,(H2,22,23,24)
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n/an/a 1n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of c-Kit (unknown origin) by TR-FRET assay


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (human))
BDBM50264437
PNG
(CHEMBL488984 | N-(2-aminopyrimidin-5-yl)-6-chloro-...)
Show SMILES Nc1ncc(NC(=O)c2c(Cl)ccc3c(Nc4cccc(c4)C(F)(F)F)noc23)cn1
Show InChI InChI=1S/C19H12ClF3N6O2/c20-13-5-4-12-15(14(13)17(30)28-11-7-25-18(24)26-8-11)31-29-16(12)27-10-3-1-2-9(6-10)19(21,22)23/h1-8H,(H,27,29)(H,28,30)(H2,24,25,26)
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n/an/a 1n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-kit (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (human))
BDBM50264392
PNG
(CHEMBL490823 | N-(6-acetamidopyridin-3-yl)-6-chlor...)
Show SMILES CC(=O)Nc1ccc(NC(=O)c2c(Cl)ccc3c(Nc4cccc(c4)C(F)(F)F)noc23)cn1
Show InChI InChI=1S/C22H15ClF3N5O3/c1-11(32)28-17-8-5-14(10-27-17)30-21(33)18-16(23)7-6-15-19(18)34-31-20(15)29-13-4-2-3-12(9-13)22(24,25)26/h2-10H,1H3,(H,29,31)(H,30,33)(H,27,28,32)
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n/an/a 1n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-kit (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (human))
BDBM50400602
PNG
(CHEMBL2206278)
Show SMILES CCN1C(C)(C)CC(CC1(C)C)Oc1ccc(nc1)C(=O)Nc1ccc(NC(=O)Nc2cc(on2)C(C)(C)C)cc1
Show InChI InChI=1S/C31H42N6O4/c1-9-37-30(5,6)17-23(18-31(37,7)8)40-22-14-15-24(32-19-22)27(38)33-20-10-12-21(13-11-20)34-28(39)35-26-16-25(41-36-26)29(2,3)4/h10-16,19,23H,9,17-18H2,1-8H3,(H,33,38)(H2,34,35,36,39)
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n/an/a 1.20n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of KIT phosphorylation in human H526 cells


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (human))
BDBM50321905
PNG
((Z)-1-(4-Methoxyphenyl)-3-[2-oxo-3-(1H-pyrrol-2-yl...)
Show SMILES COc1ccc(NC(=O)Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)cc1
Show InChI InChI=1S/C21H18N4O3/c1-28-16-7-4-13(5-8-16)23-21(27)24-15-6-9-17-18(11-14-3-2-10-22-14)20(26)25-19(17)12-15/h2-12,22H,1H3,(H,25,26)(H2,23,24,27)/b18-11-
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n/an/a 1.5n/an/an/an/an/an/a



National Taiwan University

Curated by ChEMBL


Assay Description
Inhibition of cKIT


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (human))
BDBM50430862
PNG
(CHEMBL2336040)
Show SMILES COc1cccc(NC(=O)c2ccc(C)c(c2)C#Cc2cnc3ccnn3c2)c1
Show InChI InChI=1S/C23H18N4O2/c1-16-6-8-19(23(28)26-20-4-3-5-21(13-20)29-2)12-18(16)9-7-17-14-24-22-10-11-25-27(22)15-17/h3-6,8,10-15H,1-2H3,(H,26,28)
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n/an/a 1.90n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-KIT (unknown origin) using Ser/Thr 6 peptide as substrate incubated for 1 hr prior to substrate addition measured after 2 hrs by FRET...


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (human))
BDBM50331023
PNG
((Z)-2-(5-Fluoro-2-oxo-1,2-dihydroindol-3-ylideneme...)
Show SMILES CCN(CC)CCN1CCc2[nH]c(\C=C3/C(=O)Nc4ccc(F)cc34)c(C)c2C1=O
Show InChI InChI=1S/C23H27FN4O2/c1-4-27(5-2)10-11-28-9-8-19-21(23(28)30)14(3)20(25-19)13-17-16-12-15(24)6-7-18(16)26-22(17)29/h6-7,12-13,25H,4-5,8-11H2,1-3H3,(H,26,29)/b17-13-
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n/an/a 2n/an/an/an/an/an/a



Shanghai Hengrui Pharmaceuticals Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of c-Kit after 30 mins by ELISA


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (human))
BDBM50264391
PNG
(CHEMBL523816 | N-(6-aminopyridin-3-yl)-6-chloro-3-...)
Show SMILES Nc1ccc(NC(=O)c2c(Cl)ccc3c(Nc4cccc(c4)C(F)(F)F)noc23)cn1
Show InChI InChI=1S/C20H13ClF3N5O2/c21-14-6-5-13-17(16(14)19(30)28-12-4-7-15(25)26-9-12)31-29-18(13)27-11-3-1-2-10(8-11)20(22,23)24/h1-9H,(H2,25,26)(H,27,29)(H,28,30)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-kit (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (human))
BDBM50243125
PNG
(CHEMBL487864 | N3-(6-acetamidopyridin-3-yl)-4-meth...)
Show SMILES CC(=O)Nc1ccc(NC(=O)c2cc(ccc2C)C(=O)Nc2cccc(c2)C(F)(F)F)cn1
Show InChI InChI=1S/C23H19F3N4O3/c1-13-6-7-15(21(32)29-17-5-3-4-16(11-17)23(24,25)26)10-19(13)22(33)30-18-8-9-20(27-12-18)28-14(2)31/h3-12H,1-2H3,(H,29,32)(H,30,33)(H,27,28,31)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-kit (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (human))
BDBM50215766
PNG
(4-((2-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carba...)
Show SMILES NC(=O)c1cc(CNc2ccccc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)ccn1
Show InChI InChI=1S/C21H16F2N4O4/c22-21(23)30-17-6-5-13(10-18(17)31-21)27-20(29)14-3-1-2-4-15(14)26-11-12-7-8-25-16(9-12)19(24)28/h1-10,26H,11H2,(H2,24,28)(H,27,29)
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n/an/a 2n/an/an/an/an/an/a



Bayer Research Center

Curated by ChEMBL


Assay Description
Inhibition of human recombinant cKit by FRET assay


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (human))
BDBM50260890
PNG
(3-(2-aminoquinazolin-6-yl)-1-(4-tert-butylphenyl)-...)
Show SMILES Cc1ccn(-c2ccc(cc2)C(C)(C)C)c(=O)c1-c1ccc2nc(N)ncc2c1
Show InChI InChI=1S/C24H24N4O/c1-15-11-12-28(19-8-6-18(7-9-19)24(2,3)4)22(29)21(15)16-5-10-20-17(13-16)14-26-23(25)27-20/h5-14H,1-4H3,(H2,25,26,27)
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n/an/a 2.10n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of c-Kit (unknown origin) by TR-FRET assay


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (human))
BDBM50445235
PNG
(CHEMBL3102948)
Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1ccc(OC)c(OC)c1
Show InChI InChI=1S/C23H22N2O4/c1-26-19-7-5-14(10-21(19)28-3)16-9-17-18(13-25-23(17)24-12-16)15-6-8-20(27-2)22(11-15)29-4/h5-13H,1-4H3,(H,24,25)
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n/an/a 2.10n/an/an/an/an/an/a



Korea Advanced Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of c-KIT D816V mutant (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (human))
BDBM50044955
PNG
(CHEMBL3309402)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccc(F)cc5)c(=O)c5ccccc45)cc3F)ccnc2cc1OCCCN1CCCC1
Show InChI InChI=1S/C38H33F2N5O5/c1-48-34-22-29-31(23-35(34)49-20-6-19-44-17-4-5-18-44)41-16-15-32(29)50-33-14-11-25(21-30(33)40)42-37(46)36-27-7-2-3-8-28(27)38(47)45(43-36)26-12-9-24(39)10-13-26/h2-3,7-16,21-23H,4-6,17-20H2,1H3,(H,42,46)
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n/an/a 2.20n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of c-KIT (unknown origin) after 30 mins using poly (Glu,Tyr)4:1 substrate


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (human))
BDBM13216
PNG
(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Show SMILES Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1
Show InChI InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)
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n/an/a 2.40n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-KIT (unknown origin) using Ser/Thr 6 peptide as substrate incubated for 1 hr prior to substrate addition measured after 2 hrs by FRET...


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (human))
BDBM50430867
PNG
(CHEMBL2336035)
Show SMILES Cc1ccc(NC(=O)c2ccc(C)c(c2)C#Cc2cnc3ccnn3c2)cc1
Show InChI InChI=1S/C23H18N4O/c1-16-3-9-21(10-4-16)26-23(28)20-7-5-17(2)19(13-20)8-6-18-14-24-22-11-12-25-27(22)15-18/h3-5,7,9-15H,1-2H3,(H,26,28)
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n/an/a 2.60n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-KIT (unknown origin) using Ser/Thr 6 peptide as substrate incubated for 1 hr prior to substrate addition measured after 2 hrs by FRET...


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (human))
BDBM50129828
PNG
(CHEMBL3628796)
Show SMILES COc1cc2ncnc(Nc3ccc(NC(=O)Nc4cccc(Br)c4)cc3)c2cc1OC
Show InChI InChI=1S/C23H20BrN5O3/c1-31-20-11-18-19(12-21(20)32-2)25-13-26-22(18)27-15-6-8-16(9-7-15)28-23(30)29-17-5-3-4-14(24)10-17/h3-13H,1-2H3,(H,25,26,27)(H2,28,29,30)
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n/an/a 3n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of c-Kit (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (human))
BDBM193944
PNG
(US9199981, F35)
Show SMILES Cc1ccc(cc1NC(=O)c1cnc2ccccn12)-c1noc(COC2CC(F)(F)C2(F)F)n1
Show InChI InChI=1/C22H17F4N5O3/c1-12-5-6-13(8-14(12)28-20(32)15-10-27-17-4-2-3-7-31(15)17)19-29-18(34-30-19)11-33-16-9-21(23,24)22(16,25)26/h2-8,10,16H,9,11H2,1H3,(H,28,32)
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US Patent
n/an/a 3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The compounds was tested for inhibition of SCF dependent proliferation using human Mo7e cells which endogenously express c-kit in a 384 well format. ...


US Patent US9199981 (2015)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (human))
BDBM50430868
PNG
(CHEMBL2331602)
Show SMILES Cc1cccc(NC(=O)c2ccc(C)c(c2)C#Cc2cnc3ccnn3c2)c1
Show InChI InChI=1S/C23H18N4O/c1-16-4-3-5-21(12-16)26-23(28)20-8-6-17(2)19(13-20)9-7-18-14-24-22-10-11-25-27(22)15-18/h3-6,8,10-15H,1-2H3,(H,26,28)
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n/an/a 3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-KIT (unknown origin) using Ser/Thr 6 peptide as substrate incubated for 1 hr prior to substrate addition measured after 2 hrs by FRET...


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (human))
BDBM50264439
PNG
(6-chloro-N-(pyridin-3-yl)-3-(3-(trifluoromethyl)ph...)
Show SMILES FC(F)(F)c1cccc(Nc2noc3c(C(=O)Nc4cccnc4)c(Cl)ccc23)c1
Show InChI InChI=1S/C20H12ClF3N4O2/c21-15-7-6-14-17(16(15)19(29)27-13-5-2-8-25-10-13)30-28-18(14)26-12-4-1-3-11(9-12)20(22,23)24/h1-10H,(H,26,28)(H,27,29)
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n/an/a 3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-kit (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (human))
BDBM50215774
PNG
(CHEMBL246424 | N-(2,2-difluorobenzo[d][1,3]dioxol-...)
Show SMILES CNc1nccc(CNc2ccccc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)n1
Show InChI InChI=1S/C20H17F2N5O3/c1-23-19-24-9-8-13(27-19)11-25-15-5-3-2-4-14(15)18(28)26-12-6-7-16-17(10-12)30-20(21,22)29-16/h2-10,25H,11H2,1H3,(H,26,28)(H,23,24,27)
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n/an/a 3n/an/an/an/an/an/a



Bayer Research Center

Curated by ChEMBL


Assay Description
Inhibition of human recombinant cKit by FRET assay


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (human))
BDBM50215788
PNG
(CHEMBL399534 | N-(2,2-difluorobenzo[d][1,3]dioxol-...)
Show SMILES CNc1cc(CNc2ccccc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)ccn1
Show InChI InChI=1S/C21H18F2N4O3/c1-24-19-10-13(8-9-25-19)12-26-16-5-3-2-4-15(16)20(28)27-14-6-7-17-18(11-14)30-21(22,23)29-17/h2-11,26H,12H2,1H3,(H,24,25)(H,27,28)
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n/an/a 3n/an/an/an/an/an/a



Bayer Research Center

Curated by ChEMBL


Assay Description
Inhibition of human recombinant cKit by FRET assay


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (human))
BDBM50331027
PNG
((Z)-2-(5-Fluoro-2-oxo-1,2-dihydro-indol-3-ylidenem...)
Show SMILES Cc1c(\C=C2/C(=O)Nc3ccc(F)cc23)[nH]c2CCN(CCN3CCCC3)C(=O)c12
Show InChI InChI=1S/C23H25FN4O2/c1-14-20(13-17-16-12-15(24)4-5-18(16)26-22(17)29)25-19-6-9-28(23(30)21(14)19)11-10-27-7-2-3-8-27/h4-5,12-13,25H,2-3,6-11H2,1H3,(H,26,29)/b17-13-
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n/an/a 3n/an/an/an/an/an/a



Shanghai Hengrui Pharmaceuticals Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of c-Kit after 30 mins by ELISA


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (human))
BDBM50026679
PNG
(CHEMBL3335371)
Show SMILES CC(=O)Nc1cc(Oc2ccc3n(C)c(Nc4cccc(c4)C(C)(C)C)nc3c2)ccn1
Show InChI InChI=1S/C25H27N5O2/c1-16(31)27-23-15-20(11-12-26-23)32-19-9-10-22-21(14-19)29-24(30(22)5)28-18-8-6-7-17(13-18)25(2,3)4/h6-15H,1-5H3,(H,28,29)(H,26,27,31)
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n/an/a 3n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibitory activity towards acetylcholine esterase (AChE)


ACS Med Chem Lett 6: 961-5 (2015)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (human))
BDBM50264389
PNG
(6-chloro-N-(pyrimidin-5-yl)-3-(3-(trifluoromethyl)...)
Show SMILES FC(F)(F)c1cccc(Nc2noc3c(C(=O)Nc4cncnc4)c(Cl)ccc23)c1
Show InChI InChI=1S/C19H11ClF3N5O2/c20-14-5-4-13-16(15(14)18(29)27-12-7-24-9-25-8-12)30-28-17(13)26-11-3-1-2-10(6-11)19(21,22)23/h1-9H,(H,26,28)(H,27,29)
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n/an/a 3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-kit (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (human))
BDBM25118
PNG
((3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,...)
Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O
Show InChI InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29)
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n/an/a 3n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of c-Kit


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (human))
BDBM50215793
PNG
(4-((2-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carba...)
Show SMILES CNC(=O)c1cc(CNc2ccsc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)ccn1
Show InChI InChI=1S/C20H16F2N4O4S/c1-23-18(27)14-8-11(4-6-24-14)10-25-13-5-7-31-17(13)19(28)26-12-2-3-15-16(9-12)30-20(21,22)29-15/h2-9,25H,10H2,1H3,(H,23,27)(H,26,28)
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n/an/a 3n/an/an/an/an/an/a



Bayer Research Center

Curated by ChEMBL


Assay Description
Inhibition of human recombinant cKit by FRET assay


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (human))
BDBM50321892
PNG
((Z)-5-{6-[3-(4-Methoxyphenyl)-ureido]-2-oxo-1,2-di...)
Show SMILES COc1ccc(NC(=O)Nc2ccc3\C(=C\c4[nH]cc(C(O)=O)c4C)C(=O)Nc3c2)cc1
Show InChI InChI=1S/C23H20N4O5/c1-12-18(22(29)30)11-24-19(12)10-17-16-8-5-14(9-20(16)27-21(17)28)26-23(31)25-13-3-6-15(32-2)7-4-13/h3-11,24H,1-2H3,(H,27,28)(H,29,30)(H2,25,26,31)/b17-10-
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n/an/a 3.10n/an/an/an/an/an/a



National Taiwan University

Curated by ChEMBL


Assay Description
Inhibition of cKIT


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (human))
BDBM50321895
PNG
((Z)-5-{6-[3-(4-Methoxyphenyl)-ureido]-2-oxo-1,2-di...)
Show SMILES COc1ccc(NC(=O)Nc2ccc3\C(=C\c4[nH]c(C)c(C(O)=O)c4C)C(=O)Nc3c2)cc1
Show InChI InChI=1S/C24H22N4O5/c1-12-19(25-13(2)21(12)23(30)31)11-18-17-9-6-15(10-20(17)28-22(18)29)27-24(32)26-14-4-7-16(33-3)8-5-14/h4-11,25H,1-3H3,(H,28,29)(H,30,31)(H2,26,27,32)/b18-11-
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n/an/a 3.30n/an/an/an/an/an/a



National Taiwan University

Curated by ChEMBL


Assay Description
Inhibition of cKIT


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (human))
BDBM27917
PNG
(4-cyano-N-[4-(4-methylpiperazin-1-yl)-2-(4-methylp...)
Show SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1cc(c[nH]1)C#N)N1CCN(C)CC1
Show InChI InChI=1S/C23H30N6O/c1-17-5-7-29(8-6-17)22-14-19(28-11-9-27(2)10-12-28)3-4-20(22)26-23(30)21-13-18(15-24)16-25-21/h3-4,13-14,16-17,25H,5-12H2,1-2H3,(H,26,30)
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n/an/a 3.5n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of Kit after 30 mins by fluorescence polarization


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (human))
BDBM50035354
PNG
(CHEMBL3343366)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nnn(c4C(F)(F)F)-c4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCCC1
Show InChI InChI=1S/C33H29F5N6O4/c1-46-28-18-23-25(19-29(28)47-16-4-15-43-13-2-3-14-43)39-12-11-26(23)48-27-10-7-21(17-24(27)35)40-32(45)30-31(33(36,37)38)44(42-41-30)22-8-5-20(34)6-9-22/h5-12,17-19H,2-4,13-16H2,1H3,(H,40,45)
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n/an/a 4n/an/an/an/an/an/a



Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University)

Curated by ChEMBL


Assay Description
Inhibition of c-Kit (unknown origin) using poly (Glu, Tyr) 4:1 substrate incubated for 30 mins by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (human))
BDBM21085
PNG
(3-[4-(3-amino-1,2-benzoxazol-4-yl)phenyl]-1-(3-met...)
Show SMILES COc1cccc(NC(=O)Nc2ccc(cc2)-c2cccc3onc(N)c23)c1
Show InChI InChI=1S/C21H18N4O3/c1-27-16-5-2-4-15(12-16)24-21(26)23-14-10-8-13(9-11-14)17-6-3-7-18-19(17)20(22)25-28-18/h2-12H,1H3,(H2,22,25)(H2,23,24,26)
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n/an/a 4n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (human))
BDBM50021574
PNG
(CABOZANTINIB | CHEBI:72317)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3)c2cc1OC
Show InChI InChI=1S/C28H24FN3O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34)
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n/an/a 4n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of c-Kit (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (human))
BDBM50215758
PNG
(2-((2-aminopyridin-4-yl)methylamino)-N-(2,2-difluo...)
Show SMILES Nc1cc(CNc2ccccc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)ccn1
Show InChI InChI=1S/C20H16F2N4O3/c21-20(22)28-16-6-5-13(10-17(16)29-20)26-19(27)14-3-1-2-4-15(14)25-11-12-7-8-24-18(23)9-12/h1-10,25H,11H2,(H2,23,24)(H,26,27)
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n/an/a 4n/an/an/an/an/an/a



Bayer Research Center

Curated by ChEMBL


Assay Description
Inhibition of human recombinant cKit by FRET assay


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (human))
BDBM50215759
PNG
(CHEMBL247423 | N-(2,2-difluorobenzo[d][1,3]dioxol-...)
Show SMILES OCCOCCNc1cc(CNc2ccccc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)ccn1
Show InChI InChI=1S/C24H24F2N4O5/c25-24(26)34-20-6-5-17(14-21(20)35-24)30-23(32)18-3-1-2-4-19(18)29-15-16-7-8-27-22(13-16)28-9-11-33-12-10-31/h1-8,13-14,29,31H,9-12,15H2,(H,27,28)(H,30,32)
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n/an/a 4n/an/an/an/an/an/a



Bayer Research Center

Curated by ChEMBL


Assay Description
Inhibition of human recombinant cKit by FRET assay


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (human))
BDBM50215770
PNG
(1-(5-((5-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)ca...)
Show SMILES CCNC(=O)Nc1ccc(CNc2ncsc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)cn1
Show InChI InChI=1S/C20H18F2N6O4S/c1-2-23-19(30)28-15-6-3-11(8-24-15)9-25-17-16(33-10-26-17)18(29)27-12-4-5-13-14(7-12)32-20(21,22)31-13/h3-8,10,25H,2,9H2,1H3,(H,27,29)(H2,23,24,28,30)
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n/an/a 4n/an/an/an/an/an/a



Bayer Research Center

Curated by ChEMBL


Assay Description
Inhibition of human recombinant cKit by FRET assay


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (human))
BDBM50355491
PNG
(CHEMBL1835870)
Show SMILES Nc1nc(Nc2ccc(cc2)[C@H]2CC[C@@H](CC2)N2CCOCC2)nn1-c1ccccn1
Show InChI InChI=1S/C23H29N7O/c24-22-27-23(28-30(22)21-3-1-2-12-25-21)26-19-8-4-17(5-9-19)18-6-10-20(11-7-18)29-13-15-31-16-14-29/h1-5,8-9,12,18,20H,6-7,10-11,13-16H2,(H3,24,26,27,28)/t18-,20-
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n/an/a 4n/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibition of c-KIT-mediated ERK 1/2 phosphorylation in human TF1 cells at 4 to 12 nM after 1 hr by immunoblot analysis


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (human))
BDBM50355491
PNG
(CHEMBL1835870)
Show SMILES Nc1nc(Nc2ccc(cc2)[C@H]2CC[C@@H](CC2)N2CCOCC2)nn1-c1ccccn1
Show InChI InChI=1S/C23H29N7O/c24-22-27-23(28-30(22)21-3-1-2-12-25-21)26-19-8-4-17(5-9-19)18-6-10-20(11-7-18)29-13-15-31-16-14-29/h1-5,8-9,12,18,20H,6-7,10-11,13-16H2,(H3,24,26,27,28)/t18-,20-
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n/an/a 4n/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibition of SCF-induced phosphorylation of c-KIT in human TF1 cells after 1 hr by immunoblot analysis


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (human))
BDBM50355489
PNG
(CHEMBL1835867)
Show SMILES CN1CCC(CC1)c1ccc(Nc2nc(N)n(n2)-c2ccccn2)cc1
Show InChI InChI=1S/C19H23N7/c1-25-12-9-15(10-13-25)14-5-7-16(8-6-14)22-19-23-18(20)26(24-19)17-4-2-3-11-21-17/h2-8,11,15H,9-10,12-13H2,1H3,(H3,20,22,23,24)
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n/an/a 4n/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Kit by radiometric assay


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (human))
BDBM50117312
PNG
(4-{6-Methoxy-7-[3-(4-methyl-piperidin-1-yl)-propox...)
Show SMILES COc1cc2c(ncnc2cc1OCCCN1CCC(C)CC1)N1CCN(CC1)C(=O)Nc1ccc(cc1)C#N
Show InChI InChI=1S/C30H37N7O3/c1-22-8-11-35(12-9-22)10-3-17-40-28-19-26-25(18-27(28)39-2)29(33-21-32-26)36-13-15-37(16-14-36)30(38)34-24-6-4-23(20-31)5-7-24/h4-7,18-19,21-22H,3,8-17H2,1-2H3,(H,34,38)
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n/an/a 4n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of chimeric PDGF receptor with c-kit cytoplasmic domain phosphorylation in CHO cells


J Med Chem 45: 3772-93 (2002)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT)


(Homo sapiens (human))
BDBM50331024
PNG
((Z)-2-(5-Chloro-2-oxo-1,2-dihydro-indol-3-ylidenem...)
Show SMILES CCN(CC)CCN1CCc2[nH]c(\C=C3/C(=O)Nc4ccc(Cl)cc34)c(C)c2C1=O
Show InChI InChI=1S/C23H27ClN4O2/c1-4-27(5-2)10-11-28-9-8-19-21(23(28)30)14(3)20(25-19)13-17-16-12-15(24)6-7-18(16)26-22(17)29/h6-7,12-13,25H,4-5,8-11H2,1-3H3,(H,26,29)/b17-13-
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n/an/a 4n/an/an/an/an/an/a



Shanghai Hengrui Pharmaceuticals Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of c-Kit after 30 mins by ELISA


Citation and Details
More data for this
Ligand-Target Pair
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