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Compile Data Set for Download or QSAR

Found 420 hits Enz. Inhib. hit(s) with Target = 'Matriptase'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Matriptase


(Homo sapiens (human))
BDBM51911
PNG
((4-isopropoxybenzyl)-[3-(2-methoxyphenyl)-3-(4-met...)
Show SMILES COc1ccc(cc1)C(CCNCc1ccc(OC(C)C)cc1)c1ccccc1OC
Show InChI InChI=1S/C27H33NO3/c1-20(2)31-24-13-9-21(10-14-24)19-28-18-17-25(22-11-15-23(29-3)16-12-22)26-7-5-6-8-27(26)30-4/h5-16,20,25,28H,17-19H2,1-4H3
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n/an/a 420n/an/an/an/an/an/a



Universit£ Pierre et Marie Curie-Sorbonne Universit£s (UPMC)

Curated by ChEMBL


Assay Description
Inhibition of human matriptase measured after 15 mins at pH 8 by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Matriptase


(Homo sapiens (human))
BDBM32709
PNG
((5-amino-3-pyridin-3-yl-1,2,4-triazol-1-yl)-(4-met...)
Show SMILES Cc1ccc(cc1)C(=O)n1nc(nc1N)-c1cccnc1
Show InChI InChI=1S/C15H13N5O/c1-10-4-6-11(7-5-10)14(21)20-15(16)18-13(19-20)12-3-2-8-17-9-12/h2-9H,1H3,(H2,16,18,19)
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n/an/a 570n/an/an/an/an/an/a



Universit£ Pierre et Marie Curie-Sorbonne Universit£s (UPMC)

Curated by ChEMBL


Assay Description
Inhibition of human matriptase measured after 15 mins at pH 8 by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Matriptase


(Homo sapiens (human))
BDBM50358189
PNG
(CHEMBL1921967)
Show SMILES Cc1nc(sc1C)N1C(C(C(=O)c2cccs2)C(=O)C1=O)c1cccs1
Show InChI InChI=1S/C18H14N2O3S3/c1-9-10(2)26-18(19-9)20-14(11-5-3-7-24-11)13(16(22)17(20)23)15(21)12-6-4-8-25-12/h3-8,13-14H,1-2H3
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n/an/a 2.60E+3n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Inhibition of acid-induced matriptase activation in human 184A1N4 cells using mAb M69 by cell-based ELISA like assay


Citation and Details
More data for this
Ligand-Target Pair
Matriptase


(Homo sapiens (human))
BDBM50358190
PNG
(CHEMBL1921968)
Show SMILES Cc1nc(sc1C)N1C(C(C(=O)c2cccs2)C(=O)C1=O)c1ccccc1
Show InChI InChI=1S/C20H16N2O3S2/c1-11-12(2)27-20(21-11)22-16(13-7-4-3-5-8-13)15(18(24)19(22)25)17(23)14-9-6-10-26-14/h3-10,15-16H,1-2H3
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n/an/a 7.00E+3n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Inhibition of acid-induced matriptase activation in human 184A1N4 cells using mAb M69 by cell-based ELISA like assay


Citation and Details
More data for this
Ligand-Target Pair
Matriptase


(Homo sapiens (human))
BDBM50358188
PNG
(CHEMBL1921966)
Show SMILES O=C(C1C(N(C(=O)C1=O)c1nccs1)c1cccs1)c1cccs1
Show InChI InChI=1S/C16H10N2O3S3/c19-13(10-4-2-7-23-10)11-12(9-3-1-6-22-9)18(15(21)14(11)20)16-17-5-8-24-16/h1-8,11-12H
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n/an/a 9.80E+3n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Inhibition of acid-induced matriptase activation in human 184A1N4 cells using mAb M69 by cell-based ELISA like assay


Citation and Details
More data for this
Ligand-Target Pair
Matriptase


(Homo sapiens (human))
BDBM50358191
PNG
(CHEMBL1921969)
Show SMILES Cc1nc(sc1C)N1C(C(C(=O)c2ccccc2)C(=O)C1=O)c1cccs1
Show InChI InChI=1S/C20H16N2O3S2/c1-11-12(2)27-20(21-11)22-16(14-9-6-10-26-14)15(18(24)19(22)25)17(23)13-7-4-3-5-8-13/h3-10,15-16H,1-2H3
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n/an/a 2.18E+4n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Inhibition of acid-induced matriptase activation in human 184A1N4 cells using mAb M69 by cell-based ELISA like assay


Citation and Details
More data for this
Ligand-Target Pair
Matriptase


(Homo sapiens (human))
BDBM33882
PNG
((5-amino-3-pyridin-3-yl-1,2,4-triazol-1-yl)-(4-chl...)
Show SMILES Nc1nc(nn1C(=O)c1ccc(Cl)cc1)-c1cccnc1
Show InChI InChI=1S/C14H10ClN5O/c15-11-5-3-9(4-6-11)13(21)20-14(16)18-12(19-20)10-2-1-7-17-8-10/h1-8H,(H2,16,18,19)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Universit£ Pierre et Marie Curie-Sorbonne Universit£s (UPMC)

Curated by ChEMBL


Assay Description
Inhibition of human matriptase measured after 15 mins at pH 8 by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Matriptase


(Homo sapiens (human))
BDBM33437
PNG
((5-amino-3-phenyl-1,2,4-triazol-1-yl)-(3,4-dimetho...)
Show SMILES COc1ccc(cc1OC)C(=O)n1nc(nc1N)-c1ccccc1
Show InChI InChI=1S/C17H16N4O3/c1-23-13-9-8-12(10-14(13)24-2)16(22)21-17(18)19-15(20-21)11-6-4-3-5-7-11/h3-10H,1-2H3,(H2,18,19,20)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Universit£ Pierre et Marie Curie-Sorbonne Universit£s (UPMC)

Curated by ChEMBL


Assay Description
Inhibition of human matriptase measured after 15 mins at pH 8 by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Matriptase


(Homo sapiens (human))
BDBM33453
PNG
((3-Amino-[1,2,4]triazol-4-yl)-(4-methoxy-phenyl)-m...)
Show SMILES COc1ccc(cc1)C(=O)n1cnnc1N
Show InChI InChI=1S/C10H10N4O2/c1-16-8-4-2-7(3-5-8)9(15)14-6-12-13-10(14)11/h2-6H,1H3,(H2,11,13)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Universit£ Pierre et Marie Curie-Sorbonne Universit£s (UPMC)

Curated by ChEMBL


Assay Description
Inhibition of human matriptase measured after 15 mins at pH 8 by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Matriptase


(Homo sapiens (human))
BDBM50444599
PNG
(CHEMBL3099875)
Show SMILES CCOc1cccc(NC(=O)C(=C/c2ccc(OCC(O)=O)c(OC)c2)\C#N)c1
Show InChI InChI=1S/C21H20N2O6/c1-3-28-17-6-4-5-16(11-17)23-21(26)15(12-22)9-14-7-8-18(19(10-14)27-2)29-13-20(24)25/h4-11H,3,13H2,1-2H3,(H,23,26)(H,24,25)/b15-9-
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n/an/a 7.50E+4n/an/an/an/an/an/a



Universit£ Pierre et Marie Curie

Curated by ChEMBL


Assay Description
Inhibition of matriptase (unknown origin) using Boc-Gln-Ala-Arg-AMC as substrate after 15 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Matriptase


(Homo sapiens (human))
BDBM50444603
PNG
(CHEMBL3099871)
Show SMILES CCOc1cc(\C=C(\C#N)C(=O)Nc2ccc(O)cc2)ccc1O
Show InChI InChI=1S/C18H16N2O4/c1-2-24-17-10-12(3-8-16(17)22)9-13(11-19)18(23)20-14-4-6-15(21)7-5-14/h3-10,21-22H,2H2,1H3,(H,20,23)/b13-9-
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n/an/a 9.80E+4n/an/an/an/an/an/a



Universit£ Pierre et Marie Curie

Curated by ChEMBL


Assay Description
Inhibition of matriptase (unknown origin) using Boc-Gln-Ala-Arg-AMC as substrate after 15 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Matriptase


(Homo sapiens (human))
BDBM50444597
PNG
(CHEMBL3099882)
Show SMILES COc1ccc(\C=C2\SC(=O)N(CNc3cc(F)ccc3C)C2=O)cc1OC
Show InChI InChI=1S/C20H19FN2O4S/c1-12-4-6-14(21)10-15(12)22-11-23-19(24)18(28-20(23)25)9-13-5-7-16(26-2)17(8-13)27-3/h4-10,22H,11H2,1-3H3/b18-9+
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n/an/a 1.03E+5n/an/an/an/an/an/a



Universit£ Pierre et Marie Curie

Curated by ChEMBL


Assay Description
Inhibition of matriptase (unknown origin) using Boc-Gln-Ala-Arg-AMC as substrate after 15 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Matriptase


(Homo sapiens (human))
BDBM50444604
PNG
(CHEMBL3099870)
Show SMILES COc1cc(\C=C(\C#N)C(=O)Nc2ccc(O)cc2)ccc1O
Show InChI InChI=1S/C17H14N2O4/c1-23-16-9-11(2-7-15(16)21)8-12(10-18)17(22)19-13-3-5-14(20)6-4-13/h2-9,20-21H,1H3,(H,19,22)/b12-8-
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n/an/a 1.11E+5n/an/an/an/an/an/a



Universit£ Pierre et Marie Curie

Curated by ChEMBL


Assay Description
Inhibition of matriptase (unknown origin) using Boc-Gln-Ala-Arg-AMC as substrate after 15 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Matriptase


(Homo sapiens (human))
BDBM50444602
PNG
(CHEMBL3099874)
Show SMILES COc1ccc(NC(=O)C(=C/c2ccc(O)c(OC)c2)\C#N)cc1
Show InChI InChI=1S/C18H16N2O4/c1-23-15-6-4-14(5-7-15)20-18(22)13(11-19)9-12-3-8-16(21)17(10-12)24-2/h3-10,21H,1-2H3,(H,20,22)/b13-9-
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n/an/a 1.20E+5n/an/an/an/an/an/a



Universit£ Pierre et Marie Curie

Curated by ChEMBL


Assay Description
Inhibition of matriptase (unknown origin) using Boc-Gln-Ala-Arg-AMC as substrate after 15 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Matriptase


(Homo sapiens (human))
BDBM50444598
PNG
(CHEMBL3099878)
Show SMILES COc1cc(\C=C(\C#N)c2nc3ccccc3[nH]2)ccc1OCC(=O)N1CCOCC1
Show InChI InChI=1S/C23H22N4O4/c1-29-21-13-16(6-7-20(21)31-15-22(28)27-8-10-30-11-9-27)12-17(14-24)23-25-18-4-2-3-5-19(18)26-23/h2-7,12-13H,8-11,15H2,1H3,(H,25,26)/b17-12-
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n/an/a 1.28E+5n/an/an/an/an/an/a



Universit£ Pierre et Marie Curie

Curated by ChEMBL


Assay Description
Inhibition of matriptase (unknown origin) using Boc-Gln-Ala-Arg-AMC as substrate after 15 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Matriptase


(Homo sapiens (human))
BDBM50444596
PNG
(CHEMBL3099883)
Show SMILES COc1ccc(\C=C\C(=O)c2ccc(O)cc2)cc1COc1ccc(Cl)cc1
Show InChI InChI=1S/C23H19ClO4/c1-27-23-13-3-16(2-12-22(26)17-4-8-20(25)9-5-17)14-18(23)15-28-21-10-6-19(24)7-11-21/h2-14,25H,15H2,1H3/b12-2+
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n/an/a 1.38E+5n/an/an/an/an/an/a



Universit£ Pierre et Marie Curie

Curated by ChEMBL


Assay Description
Inhibition of matriptase (unknown origin) using Boc-Gln-Ala-Arg-AMC as substrate after 15 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50394295
PNG
(CHEMBL2159392)
Show SMILES COc1ccc(CNC(=O)CCCNS(=O)(=O)c2cccc(c2)C(N)=N)cc1OC
Show InChI InChI=1S/C20H26N4O5S/c1-28-17-9-8-14(11-18(17)29-2)13-23-19(25)7-4-10-24-30(26,27)16-6-3-5-15(12-16)20(21)22/h3,5-6,8-9,11-12,24H,4,7,10,13H2,1-2H3,(H3,21,22)(H,23,25)
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n/an/a>5.00E+5n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 expressed in HEK-MT2 cells using fluorogenic Boc- Gln-Ala-Arg-NH-Mec as substrate measured over 400 secs by spectrop...


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50394297
PNG
(CHEMBL2159390)
Show SMILES COc1ccc(NC(=O)CCCNS(=O)(=O)c2cccc(c2)C(N)=N)cc1OC
Show InChI InChI=1S/C19H24N4O5S/c1-27-16-9-8-14(12-17(16)28-2)23-18(24)7-4-10-22-29(25,26)15-6-3-5-13(11-15)19(20)21/h3,5-6,8-9,11-12,22H,4,7,10H2,1-2H3,(H3,20,21)(H,23,24)
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University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 expressed in HEK-MT2 cells using fluorogenic Boc- Gln-Ala-Arg-NH-Mec as substrate measured over 400 secs by spectrop...


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50394301
PNG
(CHEMBL2159386)
Show SMILES COc1ccc(CNC(=O)CCCNS(=O)(=O)c2ccc(cc2)C(N)=N)cc1OC
Show InChI InChI=1S/C20H26N4O5S/c1-28-17-10-5-14(12-18(17)29-2)13-23-19(25)4-3-11-24-30(26,27)16-8-6-15(7-9-16)20(21)22/h5-10,12,24H,3-4,11,13H2,1-2H3,(H3,21,22)(H,23,25)
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University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 expressed in HEK-MT2 cells using fluorogenic Boc- Gln-Ala-Arg-NH-Mec as substrate measured over 400 secs by spectrop...


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50394302
PNG
(CHEMBL2159385)
Show SMILES COc1ccc(CNC(=O)CCNS(=O)(=O)c2ccc(cc2)C(N)=N)cc1OC
Show InChI InChI=1S/C19H24N4O5S/c1-27-16-8-3-13(11-17(16)28-2)12-22-18(24)9-10-23-29(25,26)15-6-4-14(5-7-15)19(20)21/h3-8,11,23H,9-10,12H2,1-2H3,(H3,20,21)(H,22,24)
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n/an/a>5.00E+5n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 expressed in HEK-MT2 cells using fluorogenic Boc- Gln-Ala-Arg-NH-Mec as substrate measured over 400 secs by spectrop...


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50394303
PNG
(CHEMBL2159384)
Show SMILES COc1ccc(NC(=O)CCCNS(=O)(=O)c2ccc(cc2)C(N)=N)cc1OC
Show InChI InChI=1S/C19H24N4O5S/c1-27-16-10-7-14(12-17(16)28-2)23-18(24)4-3-11-22-29(25,26)15-8-5-13(6-9-15)19(20)21/h5-10,12,22H,3-4,11H2,1-2H3,(H3,20,21)(H,23,24)
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University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 expressed in HEK-MT2 cells using fluorogenic Boc- Gln-Ala-Arg-NH-Mec as substrate measured over 400 secs by spectrop...


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50394304
PNG
(CHEMBL2159383)
Show SMILES COc1ccc(CNC(=O)CNS(=O)(=O)c2ccc(cc2)C(N)=N)cc1OC
Show InChI InChI=1S/C18H22N4O5S/c1-26-15-8-3-12(9-16(15)27-2)10-21-17(23)11-22-28(24,25)14-6-4-13(5-7-14)18(19)20/h3-9,22H,10-11H2,1-2H3,(H3,19,20)(H,21,23)
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University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 expressed in HEK-MT2 cells using fluorogenic Boc- Gln-Ala-Arg-NH-Mec as substrate measured over 400 secs by spectrop...


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50394305
PNG
(CHEMBL2159382)
Show SMILES COc1ccc(NC(=O)CCNS(=O)(=O)c2ccc(cc2)C(N)=N)cc1OC
Show InChI InChI=1S/C18H22N4O5S/c1-26-15-8-5-13(11-16(15)27-2)22-17(23)9-10-21-28(24,25)14-6-3-12(4-7-14)18(19)20/h3-8,11,21H,9-10H2,1-2H3,(H3,19,20)(H,22,23)
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University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 expressed in HEK-MT2 cells using fluorogenic Boc- Gln-Ala-Arg-NH-Mec as substrate measured over 400 secs by spectrop...


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50394307
PNG
(CHEMBL2159380)
Show SMILES COc1ccc(CNS(=O)(=O)c2cccc(c2)C(N)=N)cc1OC
Show InChI InChI=1S/C16H19N3O4S/c1-22-14-7-6-11(8-15(14)23-2)10-19-24(20,21)13-5-3-4-12(9-13)16(17)18/h3-9,19H,10H2,1-2H3,(H3,17,18)
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University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 expressed in HEK-MT2 cells using fluorogenic Boc- Gln-Ala-Arg-NH-Mec as substrate measured over 400 secs by spectrop...


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50394308
PNG
(CHEMBL2159379)
Show SMILES COc1cccc(CNS(=O)(=O)c2cccc(c2)C(N)=N)c1
Show InChI InChI=1S/C15H17N3O3S/c1-21-13-6-2-4-11(8-13)10-18-22(19,20)14-7-3-5-12(9-14)15(16)17/h2-9,18H,10H2,1H3,(H3,16,17)
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University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 expressed in HEK-MT2 cells using fluorogenic Boc- Gln-Ala-Arg-NH-Mec as substrate measured over 400 secs by spectrop...


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50394309
PNG
(CHEMBL2159378)
Show SMILES COc1ccc(CNS(=O)(=O)c2cccc(c2)C(N)=N)cc1
Show InChI InChI=1S/C15H17N3O3S/c1-21-13-7-5-11(6-8-13)10-18-22(19,20)14-4-2-3-12(9-14)15(16)17/h2-9,18H,10H2,1H3,(H3,16,17)
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University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 expressed in HEK-MT2 cells using fluorogenic Boc- Gln-Ala-Arg-NH-Mec as substrate measured over 400 secs by spectrop...


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50394310
PNG
(CHEMBL2159377)
Show SMILES NC(=N)c1cccc(c1)S(=O)(=O)NCc1ccccc1
Show InChI InChI=1S/C14H15N3O2S/c15-14(16)12-7-4-8-13(9-12)20(18,19)17-10-11-5-2-1-3-6-11/h1-9,17H,10H2,(H3,15,16)
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University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 expressed in HEK-MT2 cells using fluorogenic Boc- Gln-Ala-Arg-NH-Mec as substrate measured over 400 secs by spectrop...


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50394311
PNG
(CHEMBL2159376)
Show SMILES COc1ccc(NS(=O)(=O)c2cccc(c2)C(N)=N)cc1OC
Show InChI InChI=1S/C15H17N3O4S/c1-21-13-7-6-11(9-14(13)22-2)18-23(19,20)12-5-3-4-10(8-12)15(16)17/h3-9,18H,1-2H3,(H3,16,17)
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University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 expressed in HEK-MT2 cells using fluorogenic Boc- Gln-Ala-Arg-NH-Mec as substrate measured over 400 secs by spectrop...


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50394312
PNG
(CHEMBL2159375)
Show SMILES COc1cccc(NS(=O)(=O)c2cccc(c2)C(N)=N)c1
Show InChI InChI=1S/C14H15N3O3S/c1-20-12-6-3-5-11(9-12)17-21(18,19)13-7-2-4-10(8-13)14(15)16/h2-9,17H,1H3,(H3,15,16)
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University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 expressed in HEK-MT2 cells using fluorogenic Boc- Gln-Ala-Arg-NH-Mec as substrate measured over 400 secs by spectrop...


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50394313
PNG
(CHEMBL2159374)
Show SMILES COc1ccc(NS(=O)(=O)c2cccc(c2)C(N)=N)cc1
Show InChI InChI=1S/C14H15N3O3S/c1-20-12-7-5-11(6-8-12)17-21(18,19)13-4-2-3-10(9-13)14(15)16/h2-9,17H,1H3,(H3,15,16)
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University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 expressed in HEK-MT2 cells using fluorogenic Boc- Gln-Ala-Arg-NH-Mec as substrate measured over 400 secs by spectrop...


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50394314
PNG
(CHEMBL2159373)
Show SMILES NC(=N)c1cccc(c1)S(=O)(=O)Nc1ccccc1
Show InChI InChI=1S/C13H13N3O2S/c14-13(15)10-5-4-8-12(9-10)19(17,18)16-11-6-2-1-3-7-11/h1-9,16H,(H3,14,15)
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University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 expressed in HEK-MT2 cells using fluorogenic Boc- Gln-Ala-Arg-NH-Mec as substrate measured over 400 secs by spectrop...


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50394315
PNG
(CHEMBL2159372)
Show SMILES COc1ccc(CNS(=O)(=O)c2ccc(cc2)C(N)=N)cc1OC
Show InChI InChI=1S/C16H19N3O4S/c1-22-14-8-3-11(9-15(14)23-2)10-19-24(20,21)13-6-4-12(5-7-13)16(17)18/h3-9,19H,10H2,1-2H3,(H3,17,18)
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University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 expressed in HEK-MT2 cells using fluorogenic Boc- Gln-Ala-Arg-NH-Mec as substrate measured over 400 secs by spectrop...


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50394316
PNG
(CHEMBL2159371)
Show SMILES COc1cccc(CNS(=O)(=O)c2ccc(cc2)C(N)=N)c1
Show InChI InChI=1S/C15H17N3O3S/c1-21-13-4-2-3-11(9-13)10-18-22(19,20)14-7-5-12(6-8-14)15(16)17/h2-9,18H,10H2,1H3,(H3,16,17)
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University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 expressed in HEK-MT2 cells using fluorogenic Boc- Gln-Ala-Arg-NH-Mec as substrate measured over 400 secs by spectrop...


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50394317
PNG
(CHEMBL2159370)
Show SMILES COc1ccc(CNS(=O)(=O)c2ccc(cc2)C(N)=N)cc1
Show InChI InChI=1S/C15H17N3O3S/c1-21-13-6-2-11(3-7-13)10-18-22(19,20)14-8-4-12(5-9-14)15(16)17/h2-9,18H,10H2,1H3,(H3,16,17)
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University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 expressed in HEK-MT2 cells using fluorogenic Boc- Gln-Ala-Arg-NH-Mec as substrate measured over 400 secs by spectrop...


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50394318
PNG
(CHEMBL2159369)
Show SMILES NC(=N)c1ccc(cc1)S(=O)(=O)NCc1ccccc1
Show InChI InChI=1S/C14H15N3O2S/c15-14(16)12-6-8-13(9-7-12)20(18,19)17-10-11-4-2-1-3-5-11/h1-9,17H,10H2,(H3,15,16)
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University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 expressed in HEK-MT2 cells using fluorogenic Boc- Gln-Ala-Arg-NH-Mec as substrate measured over 400 secs by spectrop...


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50394319
PNG
(CHEMBL2159368)
Show SMILES COc1ccc(NS(=O)(=O)c2ccc(cc2)C(N)=N)cc1OC
Show InChI InChI=1S/C15H17N3O4S/c1-21-13-8-5-11(9-14(13)22-2)18-23(19,20)12-6-3-10(4-7-12)15(16)17/h3-9,18H,1-2H3,(H3,16,17)
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University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 expressed in HEK-MT2 cells using fluorogenic Boc- Gln-Ala-Arg-NH-Mec as substrate measured over 400 secs by spectrop...


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50394320
PNG
(CHEMBL2159367)
Show SMILES COc1cccc(NS(=O)(=O)c2ccc(cc2)C(N)=N)c1
Show InChI InChI=1S/C14H15N3O3S/c1-20-12-4-2-3-11(9-12)17-21(18,19)13-7-5-10(6-8-13)14(15)16/h2-9,17H,1H3,(H3,15,16)
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University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 expressed in HEK-MT2 cells using fluorogenic Boc- Gln-Ala-Arg-NH-Mec as substrate measured over 400 secs by spectrop...


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50394321
PNG
(CHEMBL2159366)
Show SMILES COc1ccc(NS(=O)(=O)c2ccc(cc2)C(N)=N)cc1
Show InChI InChI=1S/C14H15N3O3S/c1-20-12-6-4-11(5-7-12)17-21(18,19)13-8-2-10(3-9-13)14(15)16/h2-9,17H,1H3,(H3,15,16)
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University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 expressed in HEK-MT2 cells using fluorogenic Boc- Gln-Ala-Arg-NH-Mec as substrate measured over 400 secs by spectrop...


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50394274
PNG
(CHEMBL2159296)
Show SMILES NC(=[NH2+])c1ccc(cc1)S(=O)(=O)NCC(=O)Nc1cccc(c1)C(O)=O
Show InChI InChI=1S/C16H16N4O5S/c17-15(18)10-4-6-13(7-5-10)26(24,25)19-9-14(21)20-12-3-1-2-11(8-12)16(22)23/h1-8,19H,9H2,(H3,17,18)(H,20,21)(H,22,23)/p+1
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University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 expressed in HEK-MT2 cells using fluorogenic Boc- Gln-Ala-Arg-NH-Mec as substrate measured over 400 secs by spectrop...


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50394273
PNG
(CHEMBL2159297)
Show SMILES NC(=[NH2+])c1ccc(cc1)S(=O)(=O)NCCC(=O)Nc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C17H18N4O5S/c18-16(19)11-3-7-14(8-4-11)27(25,26)20-10-9-15(22)21-13-5-1-12(2-6-13)17(23)24/h1-8,20H,9-10H2,(H3,18,19)(H,21,22)(H,23,24)/p+1
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University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 expressed in HEK-MT2 cells using fluorogenic Boc- Gln-Ala-Arg-NH-Mec as substrate measured over 400 secs by spectrop...


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50394272
PNG
(CHEMBL2159298)
Show SMILES NC(=[NH2+])c1ccc(cc1)S(=O)(=O)NCCC(=O)Nc1cccc(c1)C(O)=O
Show InChI InChI=1S/C17H18N4O5S/c18-16(19)11-4-6-14(7-5-11)27(25,26)20-9-8-15(22)21-13-3-1-2-12(10-13)17(23)24/h1-7,10,20H,8-9H2,(H3,18,19)(H,21,22)(H,23,24)/p+1
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University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 expressed in HEK-MT2 cells using fluorogenic Boc- Gln-Ala-Arg-NH-Mec as substrate measured over 400 secs by spectrop...


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50394271
PNG
(CHEMBL2159299)
Show SMILES NC(=[NH2+])c1ccc(cc1)S(=O)(=O)NCCCC(=O)Nc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C18H20N4O5S/c19-17(20)12-5-9-15(10-6-12)28(26,27)21-11-1-2-16(23)22-14-7-3-13(4-8-14)18(24)25/h3-10,21H,1-2,11H2,(H3,19,20)(H,22,23)(H,24,25)/p+1
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University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 expressed in HEK-MT2 cells using fluorogenic Boc- Gln-Ala-Arg-NH-Mec as substrate measured over 400 secs by spectrop...


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50394270
PNG
(CHEMBL2159300)
Show SMILES NC(=[NH2+])c1ccc(cc1)S(=O)(=O)NCCCC(=O)Nc1cccc(c1)C(O)=O
Show InChI InChI=1S/C18H20N4O5S/c19-17(20)12-6-8-15(9-7-12)28(26,27)21-10-2-5-16(23)22-14-4-1-3-13(11-14)18(24)25/h1,3-4,6-9,11,21H,2,5,10H2,(H3,19,20)(H,22,23)(H,24,25)/p+1
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University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 expressed in HEK-MT2 cells using fluorogenic Boc- Gln-Ala-Arg-NH-Mec as substrate measured over 400 secs by spectrop...


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50394264
PNG
(CHEMBL2159361)
Show SMILES NC(=[NH2+])c1cccc(c1)S(=O)(=O)NCCCC(=O)Nc1cccc(c1)C(O)=O
Show InChI InChI=1S/C18H20N4O5S/c19-17(20)12-4-2-7-15(11-12)28(26,27)21-9-3-8-16(23)22-14-6-1-5-13(10-14)18(24)25/h1-2,4-7,10-11,21H,3,8-9H2,(H3,19,20)(H,22,23)(H,24,25)/p+1
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University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 expressed in HEK-MT2 cells using fluorogenic Boc- Gln-Ala-Arg-NH-Mec as substrate measured over 400 secs by spectrop...


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50394286
PNG
(CHEMBL2159284)
Show SMILES CC(C)(C)OC(=O)c1cccc(NC(=O)CNS(=O)(=O)c2ccc(cc2)C(N)=[NH2+])c1
Show InChI InChI=1S/C20H24N4O5S/c1-20(2,3)29-19(26)14-5-4-6-15(11-14)24-17(25)12-23-30(27,28)16-9-7-13(8-10-16)18(21)22/h4-11,23H,12H2,1-3H3,(H3,21,22)(H,24,25)/p+1
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n/an/a>5.00E+5n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 expressed in HEK-MT2 cells using fluorogenic Boc- Gln-Ala-Arg-NH-Mec as substrate measured over 400 secs by spectrop...


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More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50394285
PNG
(CHEMBL2159285)
Show SMILES CC(C)(C)OC(=O)c1ccc(NC(=O)CCNS(=O)(=O)c2ccc(cc2)C(N)=[NH2+])cc1
Show InChI InChI=1S/C21H26N4O5S/c1-21(2,3)30-20(27)15-4-8-16(9-5-15)25-18(26)12-13-24-31(28,29)17-10-6-14(7-11-17)19(22)23/h4-11,24H,12-13H2,1-3H3,(H3,22,23)(H,25,26)/p+1
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University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 expressed in HEK-MT2 cells using fluorogenic Boc- Gln-Ala-Arg-NH-Mec as substrate measured over 400 secs by spectrop...


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50394284
PNG
(CHEMBL2159286)
Show SMILES CC(C)(C)OC(=O)c1cccc(NC(=O)CCNS(=O)(=O)c2ccc(cc2)C(N)=[NH2+])c1
Show InChI InChI=1S/C21H26N4O5S/c1-21(2,3)30-20(27)15-5-4-6-16(13-15)25-18(26)11-12-24-31(28,29)17-9-7-14(8-10-17)19(22)23/h4-10,13,24H,11-12H2,1-3H3,(H3,22,23)(H,25,26)/p+1
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University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 expressed in HEK-MT2 cells using fluorogenic Boc- Gln-Ala-Arg-NH-Mec as substrate measured over 400 secs by spectrop...


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50394275
PNG
(CHEMBL2159295)
Show SMILES NC(=[NH2+])c1ccc(cc1)S(=O)(=O)NCC(=O)Nc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C16H16N4O5S/c17-15(18)10-3-7-13(8-4-10)26(24,25)19-9-14(21)20-12-5-1-11(2-6-12)16(22)23/h1-8,19H,9H2,(H3,17,18)(H,20,21)(H,22,23)/p+1
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n/an/a>5.00E+5n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 expressed in HEK-MT2 cells using fluorogenic Boc- Gln-Ala-Arg-NH-Mec as substrate measured over 400 secs by spectrop...


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50394276
PNG
(CHEMBL2159294)
Show SMILES CC(C)(C)OC(=O)c1cccc(NC(=O)CCCNS(=O)(=O)c2cccc(c2)C(N)=[NH2+])c1
Show InChI InChI=1S/C22H28N4O5S/c1-22(2,3)31-21(28)16-8-4-9-17(13-16)26-19(27)11-6-12-25-32(29,30)18-10-5-7-15(14-18)20(23)24/h4-5,7-10,13-14,25H,6,11-12H2,1-3H3,(H3,23,24)(H,26,27)/p+1
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n/an/a>5.00E+5n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 expressed in HEK-MT2 cells using fluorogenic Boc- Gln-Ala-Arg-NH-Mec as substrate measured over 400 secs by spectrop...


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50394282
PNG
(CHEMBL2159288)
Show SMILES CC(C)(C)OC(=O)c1cccc(NC(=O)CCCNS(=O)(=O)c2ccc(cc2)C(N)=[NH2+])c1
Show InChI InChI=1S/C22H28N4O5S/c1-22(2,3)31-21(28)16-6-4-7-17(14-16)26-19(27)8-5-13-25-32(29,30)18-11-9-15(10-12-18)20(23)24/h4,6-7,9-12,14,25H,5,8,13H2,1-3H3,(H3,23,24)(H,26,27)/p+1
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n/an/a>5.00E+5n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 expressed in HEK-MT2 cells using fluorogenic Boc- Gln-Ala-Arg-NH-Mec as substrate measured over 400 secs by spectrop...


Citation and Details
More data for this
Ligand-Target Pair
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