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Compile Data Set for Download or QSAR

Found 179 hits Enz. Inhib. hit(s) with Target = 'Matrix Metalloproteinase-10 (MMP-10)'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM11863
PNG
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Show SMILES ONC(=O)C1(CS(=O)(=O)c2ccc(Oc3ccc(Cl)cc3)cc2)CCOCC1
Show InChI InChI=1S/C19H20ClNO6S/c20-14-1-3-15(4-2-14)27-16-5-7-17(8-6-16)28(24,25)13-19(18(22)21-23)9-11-26-12-10-19/h1-8,23H,9-13H2,(H,21,22)
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n/an/a 0.540n/an/an/an/an/an/a



Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited , 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP10 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate after 40 mins by spectrofluorimetry


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM11863
PNG
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Show SMILES ONC(=O)C1(CS(=O)(=O)c2ccc(Oc3ccc(Cl)cc3)cc2)CCOCC1
Show InChI InChI=1S/C19H20ClNO6S/c20-14-1-3-15(4-2-14)27-16-5-7-17(8-6-16)28(24,25)13-19(18(22)21-23)9-11-26-12-10-19/h1-8,23H,9-13H2,(H,21,22)
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n/an/a 0.540n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP10 using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078191
PNG
(CHEMBL3417750)
Show SMILES ONC(=O)C1(CCC2(C1)CCNCC2)S(=O)(=O)c1ccc(Oc2ccc(OC(F)F)cc2)cc1
Show InChI InChI=1/C23H26F2N2O6S/c24-21(25)33-18-3-1-16(2-4-18)32-17-5-7-19(8-6-17)34(30,31)23(20(28)27-29)10-9-22(15-23)11-13-26-14-12-22/h1-8,21,26,29H,9-15H2,(H,27,28)
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n/an/a 3n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078196
PNG
(CHEMBL3417745)
Show SMILES ONC(=O)C1(CCC2(C1)CCNCC2)S(=O)(=O)c1ccc(Oc2ccc(OC(F)(F)F)cc2)cc1
Show InChI InChI=1/C23H25F3N2O6S/c24-23(25,26)34-18-3-1-16(2-4-18)33-17-5-7-19(8-6-17)35(31,32)22(20(29)28-30)10-9-21(15-22)11-13-27-14-12-21/h1-8,27,30H,9-15H2,(H,28,29)
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n/an/a 4n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078193
PNG
(CHEMBL3417748)
Show SMILES Cc1ccc(Oc2ccc(cc2)S(=O)(=O)C2(CCC3(C2)CCNCC3)C(=O)NO)cc1
Show InChI InChI=1/C23H28N2O5S/c1-17-2-4-18(5-3-17)30-19-6-8-20(9-7-19)31(28,29)23(21(26)25-27)11-10-22(16-23)12-14-24-15-13-22/h2-9,24,27H,10-16H2,1H3,(H,25,26)
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n/an/a 7n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078175
PNG
(CHEMBL3417766)
Show SMILES COc1ccc(Oc2ccc(cc2)S(=O)(=O)C2(CCC3(C2)CCN(CC3)C(C)=O)C(=O)NO)cc1
Show InChI InChI=1/C25H30N2O7S/c1-18(28)27-15-13-24(14-16-27)11-12-25(17-24,23(29)26-30)35(31,32)22-9-7-21(8-10-22)34-20-5-3-19(33-2)4-6-20/h3-10,30H,11-17H2,1-2H3,(H,26,29)
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n/an/a 9n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078199
PNG
(CHEMBL3417742)
Show SMILES COc1ccc(Oc2ccc(cc2)S(=O)(=O)C2(CCC3(C2)CCNCC3)C(=O)NO)cc1
Show InChI InChI=1/C23H28N2O6S/c1-30-17-2-4-18(5-3-17)31-19-6-8-20(9-7-19)32(28,29)23(21(26)25-27)11-10-22(16-23)12-14-24-15-13-22/h2-9,24,27H,10-16H2,1H3,(H,25,26)
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n/an/a 12n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078171
PNG
(CHEMBL3417770)
Show SMILES CNC(=O)c1ccc(Oc2ccc(cc2)S(=O)(=O)[C@@]2(CCC3(C2)CCNCC3)C(=O)NO)cc1
Show InChI InChI=1/C24H29N3O6S/c1-25-21(28)17-2-4-18(5-3-17)33-19-6-8-20(9-7-19)34(31,32)24(22(29)27-30)11-10-23(16-24)12-14-26-15-13-23/h2-9,26,30H,10-16H2,1H3,(H,25,28)(H,27,29)/t24-/s2
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n/an/a 12n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078189
PNG
(CHEMBL3417752)
Show SMILES ONC(=O)C1(CCC2(C1)CCNCC2)S(=O)(=O)c1ccc(Oc2ccc(cc2)C(=O)N2CCCC2)cc1
Show InChI InChI=1/C27H33N3O6S/c31-24(30-17-1-2-18-30)20-3-5-21(6-4-20)36-22-7-9-23(10-8-22)37(34,35)27(25(32)29-33)12-11-26(19-27)13-15-28-16-14-26/h3-10,28,33H,1-2,11-19H2,(H,29,32)
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n/an/a 13n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078186
PNG
(CHEMBL3417755)
Show SMILES COc1cccc(Oc2ccc(cc2)S(=O)(=O)C2(CCC3(C2)CCNCC3)C(=O)NO)c1
Show InChI InChI=1/C23H28N2O6S/c1-30-18-3-2-4-19(15-18)31-17-5-7-20(8-6-17)32(28,29)23(21(26)25-27)10-9-22(16-23)11-13-24-14-12-22/h2-8,15,24,27H,9-14,16H2,1H3,(H,25,26)
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n/an/a 14n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078176
PNG
(CHEMBL3417765)
Show SMILES COc1ccc(Oc2ccc(cc2)S(=O)(=O)C2(CCC3(C2)CCN(CCC(F)(F)F)CC3)C(=O)NO)cc1
Show InChI InChI=1/C26H31F3N2O6S/c1-36-19-2-4-20(5-3-19)37-21-6-8-22(9-7-21)38(34,35)25(23(32)30-33)11-10-24(18-25)12-15-31(16-13-24)17-14-26(27,28)29/h2-9,33H,10-18H2,1H3,(H,30,32)
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n/an/a 16n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078172
PNG
(CHEMBL3417769)
Show SMILES CNC(=O)c1ccc(Oc2ccc(cc2)S(=O)(=O)[C@]2(CCC3(C2)CCNCC3)C(=O)NO)cc1
Show InChI InChI=1/C24H29N3O6S/c1-25-21(28)17-2-4-18(5-3-17)33-19-6-8-20(9-7-19)34(31,32)24(22(29)27-30)11-10-23(16-24)12-14-26-15-13-23/h2-9,26,30H,10-16H2,1H3,(H,25,28)(H,27,29)/t24-/s2
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n/an/a 17n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078177
PNG
(CHEMBL3417764)
Show SMILES COc1ccc(Oc2ccc(cc2)S(=O)(=O)C2(CCC3(C2)CCN(C)CC3)C(=O)NO)cc1
Show InChI InChI=1/C24H30N2O6S/c1-26-15-13-23(14-16-26)11-12-24(17-23,22(27)25-28)33(29,30)21-9-7-20(8-10-21)32-19-5-3-18(31-2)4-6-19/h3-10,28H,11-17H2,1-2H3,(H,25,27)
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n/an/a 17n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078174
PNG
(CHEMBL3417767)
Show SMILES COc1ccc(cc1)C(=O)Oc1ccc(cc1)S(=O)(=O)C1(CCC2(C1)CCNCC2)C(=O)NO
Show InChI InChI=1/C24H28N2O7S/c1-32-18-4-2-17(3-5-18)21(27)33-19-6-8-20(9-7-19)34(30,31)24(22(28)26-29)11-10-23(16-24)12-14-25-15-13-23/h2-9,25,29H,10-16H2,1H3,(H,26,28)
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n/an/a 18n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078190
PNG
(CHEMBL3417751)
Show SMILES CNC(=O)c1ccc(Oc2ccc(cc2)S(=O)(=O)C2(CCC3(C2)CCNCC3)C(=O)NO)cc1
Show InChI InChI=1/C24H29N3O6S/c1-25-21(28)17-2-4-18(5-3-17)33-19-6-8-20(9-7-19)34(31,32)24(22(29)27-30)11-10-23(16-24)12-14-26-15-13-23/h2-9,26,30H,10-16H2,1H3,(H,25,28)(H,27,29)
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n/an/a 21n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078195
PNG
(CHEMBL3417746)
Show SMILES ONC(=O)C1(CCC2(C1)CCNCC2)S(=O)(=O)c1ccc(OCc2ccc(OC(F)(F)F)cc2)cc1
Show InChI InChI=1/C24H27F3N2O6S/c25-24(26,27)35-19-3-1-17(2-4-19)15-34-18-5-7-20(8-6-18)36(32,33)23(21(30)29-31)10-9-22(16-23)11-13-28-14-12-22/h1-8,28,31H,9-16H2,(H,29,30)
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n/an/a 32n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078192
PNG
(CHEMBL3417749)
Show SMILES CC(C)(C)c1ccc(Oc2ccc(cc2)S(=O)(=O)C2(CCC3(C2)CCNCC3)C(=O)NO)cc1
Show InChI InChI=1/C26H34N2O5S/c1-24(2,3)19-4-6-20(7-5-19)33-21-8-10-22(11-9-21)34(31,32)26(23(29)28-30)13-12-25(18-26)14-16-27-17-15-25/h4-11,27,30H,12-18H2,1-3H3,(H,28,29)
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n/an/a 42n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078181
PNG
(CHEMBL3417760)
Show SMILES ONC(=O)C1(CCC2(C1)CCNCC2)S(=O)(=O)c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1/C23H28N2O5S/c26-21(25-27)23(11-10-22(17-23)12-14-24-15-13-22)31(28,29)20-8-6-19(7-9-20)30-16-18-4-2-1-3-5-18/h1-9,24,27H,10-17H2,(H,25,26)
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n/an/a 54n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078187
PNG
(CHEMBL3417754)
Show SMILES COc1ccc(Oc2ccc(cc2)S(=O)(=O)C2(CCC3(C2)CCNCC3)C(=O)NO)cn1
Show InChI InChI=1/C22H27N3O6S/c1-30-19-7-4-17(14-24-19)31-16-2-5-18(6-3-16)32(28,29)22(20(26)25-27)9-8-21(15-22)10-12-23-13-11-21/h2-7,14,23,27H,8-13,15H2,1H3,(H,25,26)
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n/an/a 62n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078180
PNG
(CHEMBL3417761)
Show SMILES CNC(=O)c1ccc(COc2ccc(cc2)S(=O)(=O)C2(CCC3(C2)CCNCC3)C(=O)NO)cc1
Show InChI InChI=1/C25H31N3O6S/c1-26-22(29)19-4-2-18(3-5-19)16-34-20-6-8-21(9-7-20)35(32,33)25(23(30)28-31)11-10-24(17-25)12-14-27-15-13-24/h2-9,27,31H,10-17H2,1H3,(H,26,29)(H,28,30)
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n/an/a 68n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078200
PNG
(CHEMBL3417741)
Show SMILES COc1ccc(cc1)S(=O)(=O)C1(CCC2(C1)CCNCC2)C(=O)NO
Show InChI InChI=1/C17H24N2O5S/c1-24-13-2-4-14(5-3-13)25(22,23)17(15(20)19-21)7-6-16(12-17)8-10-18-11-9-16/h2-5,18,21H,6-12H2,1H3,(H,19,20)
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n/an/a 84n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078184
PNG
(CHEMBL3417757)
Show SMILES CNC(=O)c1cccc(Oc2ccc(cc2)S(=O)(=O)C2(CCC3(C2)CCNCC3)C(=O)NO)c1
Show InChI InChI=1/C24H29N3O6S/c1-25-21(28)17-3-2-4-19(15-17)33-18-5-7-20(8-6-18)34(31,32)24(22(29)27-30)10-9-23(16-24)11-13-26-14-12-23/h2-8,15,26,30H,9-14,16H2,1H3,(H,25,28)(H,27,29)
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n/an/a 89n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078173
PNG
(CHEMBL3417768)
Show SMILES CNC(=O)c1ccc(cc1)C(=O)Oc1ccc(cc1)S(=O)(=O)C1(CCC2(C1)CCNCC2)C(=O)NO
Show InChI InChI=1/C25H29N3O7S/c1-26-21(29)17-2-4-18(5-3-17)22(30)35-19-6-8-20(9-7-19)36(33,34)25(23(31)28-32)11-10-24(16-25)12-14-27-15-13-24/h2-9,27,32H,10-16H2,1H3,(H,26,29)(H,28,31)
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n/an/a 103n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50102750
PNG
(CHEMBL3359091)
Show SMILES COc1cccc(CNC(=O)c2nc3ccc(F)c(OCCc4ccc(cc4)C(O)=O)c3c(=O)[nH]2)c1
Show InChI InChI=1S/C26H22FN3O6/c1-35-18-4-2-3-16(13-18)14-28-25(32)23-29-20-10-9-19(27)22(21(20)24(31)30-23)36-12-11-15-5-7-17(8-6-15)26(33)34/h2-10,13H,11-12,14H2,1H3,(H,28,32)(H,33,34)(H,29,30,31)
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n/an/a 160n/an/an/an/an/an/a



Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited , 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP10 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate after 40 mins by spectrofluorimetry


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50025160
PNG
(CHEMBL3337894)
Show SMILES COc1cccc(CNC(=O)c2nc3scc(COCc4ccc(cc4)C(O)=O)c3c(=O)[nH]2)c1
Show InChI InChI=1S/C24H21N3O6S/c1-32-18-4-2-3-15(9-18)10-25-22(29)20-26-21(28)19-17(13-34-23(19)27-20)12-33-11-14-5-7-16(8-6-14)24(30)31/h2-9,13H,10-12H2,1H3,(H,25,29)(H,30,31)(H,26,27,28)
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n/an/a 160n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP10 using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078194
PNG
(CHEMBL3417747)
Show SMILES ONC(=O)C1(CCC2(C1)CCNCC2)S(=O)(=O)c1ccc(NCc2ccc(OC(F)(F)F)cc2)cc1
Show InChI InChI=1/C24H28F3N3O5S/c25-24(26,27)35-19-5-1-17(2-6-19)15-29-18-3-7-20(8-4-18)36(33,34)23(21(31)30-32)10-9-22(16-23)11-13-28-14-12-22/h1-8,28-29,32H,9-16H2,(H,30,31)
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n/an/a 184n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078198
PNG
(CHEMBL3417743)
Show SMILES COc1ccc(Oc2cccc(c2)S(=O)(=O)C2(CCC3(C2)CCNCC3)C(=O)NO)cc1
Show InChI InChI=1/C23H28N2O6S/c1-30-17-5-7-18(8-6-17)31-19-3-2-4-20(15-19)32(28,29)23(21(26)25-27)10-9-22(16-23)11-13-24-14-12-22/h2-8,15,24,27H,9-14,16H2,1H3,(H,25,26)
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n/an/a 189n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078179
PNG
(CHEMBL3417762)
Show SMILES ONC(=O)C1(CCC2(C1)CCNCC2)S(=O)(=O)c1ccc(OCCN2CCCC2=O)cc1
Show InChI InChI=1/C22H31N3O6S/c26-19-2-1-13-25(19)14-15-31-17-3-5-18(6-4-17)32(29,30)22(20(27)24-28)8-7-21(16-22)9-11-23-12-10-21/h3-6,23,28H,1-2,7-16H2,(H,24,27)
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n/an/a 435n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078182
PNG
(CHEMBL3417759)
Show SMILES CNC(=O)c1ccc(Oc2ccc(cc2)S(=O)(=O)C2(CCC3(C2)CCNCC3)C(=O)NO)cc1OC
Show InChI InChI=1/C25H31N3O7S/c1-26-22(29)20-8-5-18(15-21(20)34-2)35-17-3-6-19(7-4-17)36(32,33)25(23(30)28-31)10-9-24(16-25)11-13-27-14-12-24/h3-8,15,27,31H,9-14,16H2,1-2H3,(H,26,29)(H,28,30)
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n/an/a 713n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078185
PNG
(CHEMBL3417756)
Show SMILES COc1ccccc1Oc1ccc(cc1)S(=O)(=O)C1(CCC2(C1)CCNCC2)C(=O)NO
Show InChI InChI=1/C23H28N2O6S/c1-30-19-4-2-3-5-20(19)31-17-6-8-18(9-7-17)32(28,29)23(21(26)25-27)11-10-22(16-23)12-14-24-15-13-22/h2-9,24,27H,10-16H2,1H3,(H,25,26)
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n/an/a 739n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix Metalloproteinase-10 (MMP-10)


(Homo sapiens (Human))
BDBM26791
PNG
(benzimidazole analog., 17 | tert-butyl (3S,4S)-3-(...)
Show SMILES Cc1nc2ccccc2n1Cc1ccc(cc1)C(=O)N[C@@H]1CN(C[C@@H]1C(=O)NO)C(=O)OC(C)(C)C
Show InChI InChI=1S/C26H31N5O5/c1-16-27-20-7-5-6-8-22(20)31(16)13-17-9-11-18(12-10-17)23(32)28-21-15-30(14-19(21)24(33)29-35)25(34)36-26(2,3)4/h5-12,19,21,35H,13-15H2,1-4H3,(H,28,32)(H,29,33)/t19-,21+/m0/s1
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n/an/a 1.60E+3n/an/an/an/a7.525



Bristol-Myers Squibb Company



Assay Description
The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50204392
PNG
((3R,4R)-N-hydroxy-4-(4-((2-methylquinolin-4-yl)met...)
Show SMILES Cc1cc(Cc2ccc(cc2)C(=O)N[C@@H]2CCOC[C@@H]2C(=O)NO)c2ccccc2n1
Show InChI InChI=1S/C24H25N3O4/c1-15-12-18(19-4-2-3-5-21(19)25-15)13-16-6-8-17(9-7-16)23(28)26-22-10-11-31-14-20(22)24(29)27-30/h2-9,12,20,22,30H,10-11,13-14H2,1H3,(H,26,28)(H,27,29)/t20-,22+/m0/s1
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n/an/a 2.40E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of MMP10


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50025159
PNG
(CHEMBL3337869)
Show SMILES COc1cccc(CNC(=O)c2nc3ccccc3c(=O)[nH]2)c1
Show InChI InChI=1S/C17H15N3O3/c1-23-12-6-4-5-11(9-12)10-18-17(22)15-19-14-8-3-2-7-13(14)16(21)20-15/h2-9H,10H2,1H3,(H,18,22)(H,19,20,21)
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n/an/a 3.40E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP10 using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50025159
PNG
(CHEMBL3337869)
Show SMILES COc1cccc(CNC(=O)c2nc3ccccc3c(=O)[nH]2)c1
Show InChI InChI=1S/C17H15N3O3/c1-23-12-6-4-5-11(9-12)10-18-17(22)15-19-14-8-3-2-7-13(14)16(21)20-15/h2-9H,10H2,1H3,(H,18,22)(H,19,20,21)
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n/an/a 3.40E+3n/an/an/an/an/an/a



Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited , 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP10 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate after 40 mins by spectrofluorimetry


Citation and Details
More data for this
Ligand-Target Pair
Matrix Metalloproteinase-10 (MMP-10)


(Homo sapiens (Human))
BDBM26793
PNG
(benzimidazole analog., 19 | tert-butyl (3S,4S)-3-(...)
Show SMILES CC(C)c1nc2ccccc2n1Cc1ccc(cc1)C(=O)N[C@@H]1CN(C[C@@H]1C(=O)NO)C(=O)OC(C)(C)C
Show InChI InChI=1S/C28H35N5O5/c1-17(2)24-29-21-8-6-7-9-23(21)33(24)14-18-10-12-19(13-11-18)25(34)30-22-16-32(15-20(22)26(35)31-37)27(36)38-28(3,4)5/h6-13,17,20,22,37H,14-16H2,1-5H3,(H,30,34)(H,31,35)/t20-,22+/m0/s1
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n/an/a 4.60E+3n/an/an/an/a7.525



Bristol-Myers Squibb Company



Assay Description
The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50302107
PNG
(CHEMBL567893 | Grassystatin A)
Show SMILES COC(=O)[C@@H]1CCCN1C(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@H](C)NC(=O)[C@@H](NC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](OC(=O)[C@@H](OC(=O)[C@H](C(C)C)N(C)C)C(C)C)C(C)C)[C@@H](C)O
Show InChI InChI=1S/C58H95N9O16/c1-30(2)25-38(43(69)29-45(71)64-46(36(12)68)52(74)60-35(11)54(76)66(15)42(27-37-21-18-17-19-22-37)55(77)67-24-20-23-41(67)56(78)81-16)61-51(73)40(28-44(59)70)62-50(72)39(26-31(3)4)63-53(75)48(33(7)8)82-58(80)49(34(9)10)83-57(79)47(32(5)6)65(13)14/h17-19,21-22,30-36,38-43,46-49,68-69H,20,23-29H2,1-16H3,(H2,59,70)(H,60,74)(H,61,73)(H,62,72)(H,63,75)(H,64,71)/t35-,36+,38-,39-,40-,41-,42+,43-,46-,47-,48+,49-/m0/s1
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n/an/a 5.00E+3n/an/an/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Inhibition of MMP10 catalytic domain after 10 to 15 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078188
PNG
(CHEMBL3417753)
Show SMILES CN(C)Cc1ccc(Oc2ccc(cc2)S(=O)(=O)C2(CCC3(C2)CCNCC3)C(=O)NO)cc1
Show InChI InChI=1/C25H33N3O5S/c1-28(2)17-19-3-5-20(6-4-19)33-21-7-9-22(10-8-21)34(31,32)25(23(29)27-30)12-11-24(18-25)13-15-26-16-14-24/h3-10,26,30H,11-18H2,1-2H3,(H,27,29)
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n/an/a 7.81E+3n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078178
PNG
(CHEMBL3417763)
Show SMILES ONC(=O)C1(CCC2(C1)CCNCC2)S(=O)(=O)c1ccc(Oc2ccc(OC(F)(F)F)cc2)c(Cl)c1
Show InChI InChI=1/C23H24ClF3N2O6S/c24-18-13-17(5-6-19(18)34-15-1-3-16(4-2-15)35-23(25,26)27)36(32,33)22(20(30)29-31)8-7-21(14-22)9-11-28-12-10-21/h1-6,13,28,31H,7-12,14H2,(H,29,30)
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n/an/a 8.70E+3n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix Metalloproteinase-10 (MMP-10)


(Homo sapiens (Human))
BDBM26789
PNG
(benzimidazole analog., 15 | tert-butyl (3S,4S)-3-(...)
Show SMILES CSc1nc2ccccc2n1Cc1ccc(cc1)C(=O)N[C@@H]1CN(C[C@@H]1C(=O)NO)C(=O)OC(C)(C)C
Show InChI InChI=1S/C26H31N5O5S/c1-26(2,3)36-25(34)30-14-18(23(33)29-35)20(15-30)27-22(32)17-11-9-16(10-12-17)13-31-21-8-6-5-7-19(21)28-24(31)37-4/h5-12,18,20,35H,13-15H2,1-4H3,(H,27,32)(H,29,33)/t18-,20+/m0/s1
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n/an/a>1.00E+4n/an/an/an/a7.525



Bristol-Myers Squibb Company



Assay Description
The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM26806
PNG
((3R,4R)-3-N-hydroxy-4-N-(4-{[2-(trifluoromethyl)-1...)
Show SMILES ONC(=O)[C@H]1COCC[C@H]1NC(=O)c1ccc(Cn2c(nc3ccccc23)C(F)(F)F)cc1
Show InChI InChI=1S/C22H21F3N4O4/c23-22(24,25)21-27-17-3-1-2-4-18(17)29(21)11-13-5-7-14(8-6-13)19(30)26-16-9-10-33-12-15(16)20(31)28-32/h1-8,15-16,32H,9-12H2,(H,26,30)(H,28,31)/t15-,16+/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of MMP10


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078170
PNG
(CHEMBL3417740)
Show SMILES ONC(=O)C1(CCC2(C1)CCNCC2)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1/C16H21FN2O4S/c17-12-1-3-13(4-2-12)24(22,23)16(14(20)19-21)6-5-15(11-16)7-9-18-10-8-15/h1-4,18,21H,5-11H2,(H,19,20)
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n/an/a 1.14E+4n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50361618
PNG
(CHEMBL1939876 | US8785489, 4-{[({5-[2-(ethoxycarbo...)
Show SMILES CCOC(=O)c1cc2cc(ccc2[nH]1)-c1cc(nn1C)C(=O)NCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H22N4O5/c1-3-33-24(32)20-11-17-10-16(8-9-18(17)26-20)21-12-19(27-28(21)2)22(29)25-13-14-4-6-15(7-5-14)23(30)31/h4-12,26H,3,13H2,1-2H3,(H,25,29)(H,30,31)
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n/an/a 1.60E+4n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP10 after 30 mins by fluorimetry


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078183
PNG
(CHEMBL3417758)
Show SMILES CNC(=O)c1ccccc1Oc1ccc(cc1)S(=O)(=O)C1(CCC2(C1)CCNCC2)C(=O)NO
Show InChI InChI=1/C24H29N3O6S/c1-25-21(28)19-4-2-3-5-20(19)33-17-6-8-18(9-7-17)34(31,32)24(22(29)27-30)11-10-23(16-24)12-14-26-15-13-23/h2-9,26,30H,10-16H2,1H3,(H,25,28)(H,27,29)
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n/an/a 2.07E+4n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078197
PNG
(CHEMBL3417744)
Show SMILES COc1ccc(Oc2ccccc2S(=O)(=O)C2(CCC3(C2)CCNCC3)C(=O)NO)cc1
Show InChI InChI=1/C23H28N2O6S/c1-30-17-6-8-18(9-7-17)31-19-4-2-3-5-20(19)32(28,29)23(21(26)25-27)11-10-22(16-23)12-14-24-15-13-22/h2-9,24,27H,10-16H2,1H3,(H,25,26)
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n/an/a 2.54E+4n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50037061
PNG
(2-(2,5-Dimethoxy-phenyl)-isothiazolo[5,4-b]pyridin...)
Show SMILES COc1ccc(OC)c(c1)-n1sc2ncccc2c1=O
Show InChI InChI=1S/C14H12N2O3S/c1-18-9-5-6-12(19-2)11(8-9)16-14(17)10-4-3-7-15-13(10)20-16/h3-8H,1-2H3
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n/an/a 5.30E+4n/an/an/an/an/an/a



DuPont Merck Pharmaceutical Company

Curated by ChEMBL


Assay Description
Tested for the inhibition of prostromelysin activation with no preincubation period


J Med Chem 37: 3071-8 (1994)

More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50037075
PNG
(2-(2,4-Dimethoxy-phenyl)-isothiazolo[5,4-b]pyridin...)
Show SMILES COc1ccc(c(OC)c1)-n1sc2ncccc2c1=O
Show InChI InChI=1S/C14H12N2O3S/c1-18-9-5-6-11(12(8-9)19-2)16-14(17)10-4-3-7-15-13(10)20-16/h3-8H,1-2H3
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n/an/a 6.20E+4n/an/an/an/an/an/a



DuPont Merck Pharmaceutical Company

Curated by ChEMBL


Assay Description
Tested for the inhibition of prostromelysin activation with no preincubation period


J Med Chem 37: 3071-8 (1994)

More data for this
Ligand-Target Pair
Matrix Metalloproteinase-10 (MMP-10)


(Homo sapiens (Human))
BDBM29018
PNG
((1S,5S,7R)-3-N-hydroxy-7-N-[(4-phenylphenyl)methyl...)
Show SMILES ONC(=O)N1C[C@H]2O[C@@H](C1)[C@@H](O2)C(=O)NCc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C20H21N3O5/c24-19(18-16-11-23(20(25)22-26)12-17(27-16)28-18)21-10-13-6-8-15(9-7-13)14-4-2-1-3-5-14/h1-9,16-18,26H,10-12H2,(H,21,24)(H,22,25)/t16-,17-,18+/m0/s1
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n/an/a 8.65E+5n/an/an/an/a7.025



University of Florence



Assay Description
The inhibition potency (IC50) was measured by fluorescent enzymatic assays. The compounds were evaluated for their ability to inhibit the hydrolysis ...


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM120222
PNG
(US8691753, 71)
Show SMILES OC(=O)CC[C@H](NC(=O)CCc1ccc(cc1)-c1ccc(cc1)-c1ccccc1)C(=O)Nc1cccc(CC(O)=O)c1
Show InChI InChI=1S/C34H32N2O6/c37-31(36-30(18-20-32(38)39)34(42)35-29-8-4-5-24(21-29)22-33(40)41)19-11-23-9-12-26(13-10-23)28-16-14-27(15-17-28)25-6-2-1-3-7-25/h1-10,12-17,21,30H,11,18-20,22H2,(H,35,42)(H,36,37)(H,38,39)(H,40,41)/t30-/m0/s1
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US Patent
7.70n/an/an/an/an/an/an/an/a



Commissariat A l'Energie Atomique et Aux Energies Alternatives

US Patent


Assay Description
The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...


US Patent US8691753 (2014)

More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM92441
PNG
(RXP470, 1 | RXP470, Compound 4)
Show SMILES NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)C(Cc1cc(no1)-c1ccc(cc1)-c1cccc(Cl)c1)CP(O)(=O)c1ccc(Br)cc1
Show InChI InChI=1S/C35H35BrClN4O10P/c36-24-8-10-27(11-9-24)52(49,50)19-23(34(47)40-29(13-15-32(44)45)35(48)39-28(33(38)46)12-14-31(42)43)17-26-18-30(41-51-26)21-6-4-20(5-7-21)22-2-1-3-25(37)16-22/h1-11,16,18,23,28-29H,12-15,17,19H2,(H2,38,46)(H,39,48)(H,40,47)(H,42,43)(H,44,45)(H,49,50)/t23?,28-,29+/m1/s1
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8 -46.2n/an/an/an/an/a6.825



Commissariat á l'Energie Atomique



Assay Description
Enzyme assay using human matrix metalloproteases or ADAMTS.


Citation and Details
More data for this
Ligand-Target Pair
Matrix Metalloproteinase-10 (MMP-10)


(Homo sapiens (Human))
BDBM92441
PNG
(RXP470, 1 | RXP470, Compound 4)
Show SMILES NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)C(Cc1cc(no1)-c1ccc(cc1)-c1cccc(Cl)c1)CP(O)(=O)c1ccc(Br)cc1
Show InChI InChI=1S/C35H35BrClN4O10P/c36-24-8-10-27(11-9-24)52(49,50)19-23(34(47)40-29(13-15-32(44)45)35(48)39-28(33(38)46)12-14-31(42)43)17-26-18-30(41-51-26)21-6-4-20(5-7-21)22-2-1-3-25(37)16-22/h1-11,16,18,23,28-29H,12-15,17,19H2,(H2,38,46)(H,39,48)(H,40,47)(H,42,43)(H,44,45)(H,49,50)/t23?,28-,29+/m1/s1
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8.30 -46.1n/an/an/an/an/a6.825



Commissariat à l'Energie Atomique



Assay Description
Enzyme assay using matrix metalloproteinases.


Citation and Details
More data for this
Ligand-Target Pair
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