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Compile Data Set for Download or QSAR

Found 202 hits Enz. Inhib. hit(s) with Target = 'Matrix Metalloproteinase-10 (MMP-10)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50203953
PNG
(CHEMBL3932562)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1cccc(CNC(=O)c2nc3ccccc3c(=O)[nH]2)c1)C(=O)NO
Show InChI InChI=1S/C27H27N5O6S/c1-16(2)23(26(34)31-36)32-39(37,38)20-12-10-18(11-13-20)19-7-5-6-17(14-19)15-28-27(35)24-29-22-9-4-3-8-21(22)25(33)30-24/h3-14,16,23,32,36H,15H2,1-2H3,(H,28,35)(H,31,34)(H,29,30,33)/t23-/m0/s1
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n/an/a 0.300n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of recombinant human AMPA-activated MMP10 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate measured after 40 mins by spectrofluorimetric method


Bioorg Med Chem 24: 6149-6165 (2016)


Article DOI: 10.1016/j.bmc.2016.09.009
BindingDB Entry DOI: 10.7270/Q2H1341V
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50204002
PNG
(CHEMBL3889936)
Show SMILES CC(C)C(CS(=O)(=O)c1ccc(cc1)-c1cccc(CNC(=O)c2nc3ccccc3c(=O)[nH]2)c1)N(O)C=O
Show InChI InChI=1S/C28H28N4O6S/c1-18(2)25(32(36)17-33)16-39(37,38)22-12-10-20(11-13-22)21-7-5-6-19(14-21)15-29-28(35)26-30-24-9-4-3-8-23(24)27(34)31-26/h3-14,17-18,25,36H,15-16H2,1-2H3,(H,29,35)(H,30,31,34)
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n/an/a 0.350n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of recombinant human AMPA-activated MMP10 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate measured after 40 mins by spectrofluorimetric method


Bioorg Med Chem 24: 6149-6165 (2016)


Article DOI: 10.1016/j.bmc.2016.09.009
BindingDB Entry DOI: 10.7270/Q2H1341V
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM11863
PNG
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Show SMILES ONC(=O)C1(CS(=O)(=O)c2ccc(Oc3ccc(Cl)cc3)cc2)CCOCC1
Show InChI InChI=1S/C19H20ClNO6S/c20-14-1-3-15(4-2-14)27-16-5-7-17(8-6-16)28(24,25)13-19(18(22)21-23)9-11-26-12-10-19/h1-8,23H,9-13H2,(H,21,22)
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n/an/a 0.540n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of recombinant human AMPA-activated MMP10 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate measured after 40 mins by spectrofluorimetric method


Bioorg Med Chem 24: 6149-6165 (2016)


Article DOI: 10.1016/j.bmc.2016.09.009
BindingDB Entry DOI: 10.7270/Q2H1341V
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM11863
PNG
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Show SMILES ONC(=O)C1(CS(=O)(=O)c2ccc(Oc3ccc(Cl)cc3)cc2)CCOCC1
Show InChI InChI=1S/C19H20ClNO6S/c20-14-1-3-15(4-2-14)27-16-5-7-17(8-6-16)28(24,25)13-19(18(22)21-23)9-11-26-12-10-19/h1-8,23H,9-13H2,(H,21,22)
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n/an/a 0.540n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP10 using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assay


Bioorg Med Chem 22: 5487-505 (2014)


Article DOI: 10.1016/j.bmc.2014.07.025
BindingDB Entry DOI: 10.7270/Q27S7QBJ
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM11863
PNG
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Show SMILES ONC(=O)C1(CS(=O)(=O)c2ccc(Oc3ccc(Cl)cc3)cc2)CCOCC1
Show InChI InChI=1S/C19H20ClNO6S/c20-14-1-3-15(4-2-14)27-16-5-7-17(8-6-16)28(24,25)13-19(18(22)21-23)9-11-26-12-10-19/h1-8,23H,9-13H2,(H,21,22)
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n/an/a 0.540n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP10 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate after 40 mins by spectrofluorimetry


J Med Chem 57: 8886-902 (2014)


Article DOI: 10.1021/jm500981k
BindingDB Entry DOI: 10.7270/Q28P628P
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50203956
PNG
(CHEMBL3971135)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1cccc(CNC(=O)c2nc3ccccc3c(=O)[nH]2)c1)C(O)=O
Show InChI InChI=1S/C27H26N4O6S/c1-16(2)23(27(34)35)31-38(36,37)20-12-10-18(11-13-20)19-7-5-6-17(14-19)15-28-26(33)24-29-22-9-4-3-8-21(22)25(32)30-24/h3-14,16,23,31H,15H2,1-2H3,(H,28,33)(H,34,35)(H,29,30,32)/t23-/m0/s1
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n/an/a 2.40n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of recombinant human AMPA-activated MMP10 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate measured after 40 mins by spectrofluorimetric method


Bioorg Med Chem 24: 6149-6165 (2016)


Article DOI: 10.1016/j.bmc.2016.09.009
BindingDB Entry DOI: 10.7270/Q2H1341V
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50203961
PNG
(CHEMBL3958969)
Show SMILES ONC(=O)C1CCCCN1S(=O)(=O)CCCOc1cccc(CNC(=O)c2nc3ccccc3c(=O)[nH]2)c1
Show InChI InChI=1S/C25H29N5O7S/c31-23-19-9-1-2-10-20(19)27-22(28-23)25(33)26-16-17-7-5-8-18(15-17)37-13-6-14-38(35,36)30-12-4-3-11-21(30)24(32)29-34/h1-2,5,7-10,15,21,34H,3-4,6,11-14,16H2,(H,26,33)(H,29,32)(H,27,28,31)
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n/an/a 2.60n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of recombinant human AMPA-activated MMP10 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate measured after 40 mins by spectrofluorimetric method


Bioorg Med Chem 24: 6149-6165 (2016)


Article DOI: 10.1016/j.bmc.2016.09.009
BindingDB Entry DOI: 10.7270/Q2H1341V
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078191
PNG
(CHEMBL3417750)
Show SMILES ONC(=O)C1(CCC2(C1)CCNCC2)S(=O)(=O)c1ccc(Oc2ccc(OC(F)F)cc2)cc1
Show InChI InChI=1S/C23H26F2N2O6S/c24-21(25)33-18-3-1-16(2-4-18)32-17-5-7-19(8-6-17)34(30,31)23(20(28)27-29)10-9-22(15-23)11-13-26-14-12-22/h1-8,21,26,29H,9-15H2,(H,27,28)
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n/an/a 3n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


J Med Chem 58: 2465-88 (2015)


Article DOI: 10.1021/jm501940y
BindingDB Entry DOI: 10.7270/Q28C9XXK
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078196
PNG
(CHEMBL3417745)
Show SMILES ONC(=O)C1(CCC2(C1)CCNCC2)S(=O)(=O)c1ccc(Oc2ccc(OC(F)(F)F)cc2)cc1
Show InChI InChI=1S/C23H25F3N2O6S/c24-23(25,26)34-18-3-1-16(2-4-18)33-17-5-7-19(8-6-17)35(31,32)22(20(29)28-30)10-9-21(15-22)11-13-27-14-12-21/h1-8,27,30H,9-15H2,(H,28,29)
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n/an/a 4n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


J Med Chem 58: 2465-88 (2015)


Article DOI: 10.1021/jm501940y
BindingDB Entry DOI: 10.7270/Q28C9XXK
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50203959
PNG
(CHEMBL3955430)
Show SMILES O=C(Cc1n[nH]c(=O)[nH]1)N1CCN(CC1)c1cccc(CNC(=O)c2nc3ccccc3c(=O)[nH]2)c1
Show InChI InChI=1S/C24H24N8O4/c33-20(13-19-27-24(36)30-29-19)32-10-8-31(9-11-32)16-5-3-4-15(12-16)14-25-23(35)21-26-18-7-2-1-6-17(18)22(34)28-21/h1-7,12H,8-11,13-14H2,(H,25,35)(H,26,28,34)(H2,27,29,30,36)
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n/an/a 6.20n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of recombinant human AMPA-activated MMP10 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate measured after 40 mins by spectrofluorimetric method


Bioorg Med Chem 24: 6149-6165 (2016)


Article DOI: 10.1016/j.bmc.2016.09.009
BindingDB Entry DOI: 10.7270/Q2H1341V
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078193
PNG
(CHEMBL3417748)
Show SMILES Cc1ccc(Oc2ccc(cc2)S(=O)(=O)C2(CCC3(C2)CCNCC3)C(=O)NO)cc1
Show InChI InChI=1S/C23H28N2O5S/c1-17-2-4-18(5-3-17)30-19-6-8-20(9-7-19)31(28,29)23(21(26)25-27)11-10-22(16-23)12-14-24-15-13-22/h2-9,24,27H,10-16H2,1H3,(H,25,26)
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n/an/a 7n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


J Med Chem 58: 2465-88 (2015)


Article DOI: 10.1021/jm501940y
BindingDB Entry DOI: 10.7270/Q28C9XXK
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078175
PNG
(CHEMBL3417766)
Show SMILES COc1ccc(Oc2ccc(cc2)S(=O)(=O)C2(CCC3(C2)CCN(CC3)C(C)=O)C(=O)NO)cc1
Show InChI InChI=1S/C25H30N2O7S/c1-18(28)27-15-13-24(14-16-27)11-12-25(17-24,23(29)26-30)35(31,32)22-9-7-21(8-10-22)34-20-5-3-19(33-2)4-6-20/h3-10,30H,11-17H2,1-2H3,(H,26,29)
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n/an/a 9n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


J Med Chem 58: 2465-88 (2015)


Article DOI: 10.1021/jm501940y
BindingDB Entry DOI: 10.7270/Q28C9XXK
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50203963
PNG
(CHEMBL3907881)
Show SMILES O=C(CC1NC(=O)NC1=O)N1CCN(CC1)c1cccc(CNC(=O)c2nc3ccccc3c(=O)[nH]2)c1
Show InChI InChI=1S/C25H25N7O5/c33-20(13-19-23(35)30-25(37)28-19)32-10-8-31(9-11-32)16-5-3-4-15(12-16)14-26-24(36)21-27-18-7-2-1-6-17(18)22(34)29-21/h1-7,12,19H,8-11,13-14H2,(H,26,36)(H,27,29,34)(H2,28,30,35,37)
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n/an/a<10n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of recombinant human AMPA-activated MMP10 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate measured after 40 mins by spectrofluorimetric method


Bioorg Med Chem 24: 6149-6165 (2016)


Article DOI: 10.1016/j.bmc.2016.09.009
BindingDB Entry DOI: 10.7270/Q2H1341V
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50203962
PNG
(CHEMBL3917494)
Show SMILES CC(C)C(CS(=O)(=O)c1ccc(cc1)-c1cccc(CNC(=O)c2nc3ccccc3c(=O)[nH]2)c1)N(O)C(N)=O
Show InChI InChI=1S/C28H29N5O6S/c1-17(2)24(33(37)28(29)36)16-40(38,39)21-12-10-19(11-13-21)20-7-5-6-18(14-20)15-30-27(35)25-31-23-9-4-3-8-22(23)26(34)32-25/h3-14,17,24,37H,15-16H2,1-2H3,(H2,29,36)(H,30,35)(H,31,32,34)
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n/an/a<10n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of recombinant human AMPA-activated MMP10 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate measured after 40 mins by spectrofluorimetric method


Bioorg Med Chem 24: 6149-6165 (2016)


Article DOI: 10.1016/j.bmc.2016.09.009
BindingDB Entry DOI: 10.7270/Q2H1341V
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50204009
PNG
(CHEMBL3927817)
Show SMILES O=C(Cc1cc(=O)[nH][nH]1)N1CCN(CC1)c1cccc(CNC(=O)c2nc3ccccc3c(=O)[nH]2)c1
Show InChI InChI=1S/C25H25N7O4/c33-21-13-17(29-30-21)14-22(34)32-10-8-31(9-11-32)18-5-3-4-16(12-18)15-26-25(36)23-27-20-7-2-1-6-19(20)24(35)28-23/h1-7,12-13H,8-11,14-15H2,(H,26,36)(H,27,28,35)(H2,29,30,33)
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n/an/a<10n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of recombinant human AMPA-activated MMP10 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate measured after 40 mins by spectrofluorimetric method


Bioorg Med Chem 24: 6149-6165 (2016)


Article DOI: 10.1016/j.bmc.2016.09.009
BindingDB Entry DOI: 10.7270/Q2H1341V
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078199
PNG
(CHEMBL3417742)
Show SMILES COc1ccc(Oc2ccc(cc2)S(=O)(=O)C2(CCC3(C2)CCNCC3)C(=O)NO)cc1
Show InChI InChI=1S/C23H28N2O6S/c1-30-17-2-4-18(5-3-17)31-19-6-8-20(9-7-19)32(28,29)23(21(26)25-27)11-10-22(16-23)12-14-24-15-13-22/h2-9,24,27H,10-16H2,1H3,(H,25,26)
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n/an/a 12n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


J Med Chem 58: 2465-88 (2015)


Article DOI: 10.1021/jm501940y
BindingDB Entry DOI: 10.7270/Q28C9XXK
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078171
PNG
(CHEMBL3417770)
Show SMILES CNC(=O)c1ccc(Oc2ccc(cc2)S(=O)(=O)[C@@]2(CCC3(C2)CCNCC3)C(=O)NO)cc1
Show InChI InChI=1S/C24H29N3O6S/c1-25-21(28)17-2-4-18(5-3-17)33-19-6-8-20(9-7-19)34(31,32)24(22(29)27-30)11-10-23(16-24)12-14-26-15-13-23/h2-9,26,30H,10-16H2,1H3,(H,25,28)(H,27,29)/t24-/m1/s1
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n/an/a 12n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


J Med Chem 58: 2465-88 (2015)


Article DOI: 10.1021/jm501940y
BindingDB Entry DOI: 10.7270/Q28C9XXK
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078189
PNG
(CHEMBL3417752)
Show SMILES ONC(=O)C1(CCC2(C1)CCNCC2)S(=O)(=O)c1ccc(Oc2ccc(cc2)C(=O)N2CCCC2)cc1
Show InChI InChI=1S/C27H33N3O6S/c31-24(30-17-1-2-18-30)20-3-5-21(6-4-20)36-22-7-9-23(10-8-22)37(34,35)27(25(32)29-33)12-11-26(19-27)13-15-28-16-14-26/h3-10,28,33H,1-2,11-19H2,(H,29,32)
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n/an/a 13n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


J Med Chem 58: 2465-88 (2015)


Article DOI: 10.1021/jm501940y
BindingDB Entry DOI: 10.7270/Q28C9XXK
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078186
PNG
(CHEMBL3417755)
Show SMILES COc1cccc(Oc2ccc(cc2)S(=O)(=O)C2(CCC3(C2)CCNCC3)C(=O)NO)c1
Show InChI InChI=1S/C23H28N2O6S/c1-30-18-3-2-4-19(15-18)31-17-5-7-20(8-6-17)32(28,29)23(21(26)25-27)10-9-22(16-23)11-13-24-14-12-22/h2-8,15,24,27H,9-14,16H2,1H3,(H,25,26)
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n/an/a 14n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


J Med Chem 58: 2465-88 (2015)


Article DOI: 10.1021/jm501940y
BindingDB Entry DOI: 10.7270/Q28C9XXK
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078176
PNG
(CHEMBL3417765)
Show SMILES COc1ccc(Oc2ccc(cc2)S(=O)(=O)C2(CCC3(C2)CCN(CCC(F)(F)F)CC3)C(=O)NO)cc1
Show InChI InChI=1S/C26H31F3N2O6S/c1-36-19-2-4-20(5-3-19)37-21-6-8-22(9-7-21)38(34,35)25(23(32)30-33)11-10-24(18-25)12-15-31(16-13-24)17-14-26(27,28)29/h2-9,33H,10-18H2,1H3,(H,30,32)
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n/an/a 16n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


J Med Chem 58: 2465-88 (2015)


Article DOI: 10.1021/jm501940y
BindingDB Entry DOI: 10.7270/Q28C9XXK
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078177
PNG
(CHEMBL3417764)
Show SMILES COc1ccc(Oc2ccc(cc2)S(=O)(=O)C2(CCC3(C2)CCN(C)CC3)C(=O)NO)cc1
Show InChI InChI=1S/C24H30N2O6S/c1-26-15-13-23(14-16-26)11-12-24(17-23,22(27)25-28)33(29,30)21-9-7-20(8-10-21)32-19-5-3-18(31-2)4-6-19/h3-10,28H,11-17H2,1-2H3,(H,25,27)
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n/an/a 17n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


J Med Chem 58: 2465-88 (2015)


Article DOI: 10.1021/jm501940y
BindingDB Entry DOI: 10.7270/Q28C9XXK
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078172
PNG
(CHEMBL3417769)
Show SMILES CNC(=O)c1ccc(Oc2ccc(cc2)S(=O)(=O)[C@]2(CCC3(C2)CCNCC3)C(=O)NO)cc1
Show InChI InChI=1S/C24H29N3O6S/c1-25-21(28)17-2-4-18(5-3-17)33-19-6-8-20(9-7-19)34(31,32)24(22(29)27-30)11-10-23(16-24)12-14-26-15-13-23/h2-9,26,30H,10-16H2,1H3,(H,25,28)(H,27,29)/t24-/m0/s1
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n/an/a 17n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


J Med Chem 58: 2465-88 (2015)


Article DOI: 10.1021/jm501940y
BindingDB Entry DOI: 10.7270/Q28C9XXK
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078174
PNG
(CHEMBL3417767)
Show SMILES COc1ccc(cc1)C(=O)Oc1ccc(cc1)S(=O)(=O)C1(CCC2(C1)CCNCC2)C(=O)NO
Show InChI InChI=1S/C24H28N2O7S/c1-32-18-4-2-17(3-5-18)21(27)33-19-6-8-20(9-7-19)34(30,31)24(22(28)26-29)11-10-23(16-24)12-14-25-15-13-23/h2-9,25,29H,10-16H2,1H3,(H,26,28)
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n/an/a 18n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


J Med Chem 58: 2465-88 (2015)


Article DOI: 10.1021/jm501940y
BindingDB Entry DOI: 10.7270/Q28C9XXK
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078190
PNG
(CHEMBL3417751)
Show SMILES CNC(=O)c1ccc(Oc2ccc(cc2)S(=O)(=O)C2(CCC3(C2)CCNCC3)C(=O)NO)cc1
Show InChI InChI=1S/C24H29N3O6S/c1-25-21(28)17-2-4-18(5-3-17)33-19-6-8-20(9-7-19)34(31,32)24(22(29)27-30)11-10-23(16-24)12-14-26-15-13-23/h2-9,26,30H,10-16H2,1H3,(H,25,28)(H,27,29)
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n/an/a 21n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


J Med Chem 58: 2465-88 (2015)


Article DOI: 10.1021/jm501940y
BindingDB Entry DOI: 10.7270/Q28C9XXK
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078195
PNG
(CHEMBL3417746)
Show SMILES ONC(=O)C1(CCC2(C1)CCNCC2)S(=O)(=O)c1ccc(OCc2ccc(OC(F)(F)F)cc2)cc1
Show InChI InChI=1S/C24H27F3N2O6S/c25-24(26,27)35-19-3-1-17(2-4-19)15-34-18-5-7-20(8-6-18)36(32,33)23(21(30)29-31)10-9-22(16-23)11-13-28-14-12-22/h1-8,28,31H,9-16H2,(H,29,30)
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n/an/a 32n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


J Med Chem 58: 2465-88 (2015)


Article DOI: 10.1021/jm501940y
BindingDB Entry DOI: 10.7270/Q28C9XXK
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50203957
PNG
(CHEMBL3900916)
Show SMILES Clc1cccc(c1)-c1csc2nc([nH]c(=O)c12)C(=O)NCc1cccc(c1)-c1ccc(CS(=O)(=O)Cc2n[nH]c(=O)[nH]2)cc1
Show InChI InChI=1S/C30H23ClN6O5S2/c31-22-6-2-5-21(12-22)23-14-43-29-25(23)27(38)34-26(35-29)28(39)32-13-18-3-1-4-20(11-18)19-9-7-17(8-10-19)15-44(41,42)16-24-33-30(40)37-36-24/h1-12,14H,13,15-16H2,(H,32,39)(H,34,35,38)(H2,33,36,37,40)
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n/an/a 34n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of recombinant human AMPA-activated MMP10 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate measured after 40 mins by spectrofluorimetric method


Bioorg Med Chem 24: 6149-6165 (2016)


Article DOI: 10.1016/j.bmc.2016.09.009
BindingDB Entry DOI: 10.7270/Q2H1341V
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078192
PNG
(CHEMBL3417749)
Show SMILES CC(C)(C)c1ccc(Oc2ccc(cc2)S(=O)(=O)C2(CCC3(C2)CCNCC3)C(=O)NO)cc1
Show InChI InChI=1S/C26H34N2O5S/c1-24(2,3)19-4-6-20(7-5-19)33-21-8-10-22(11-9-21)34(31,32)26(23(29)28-30)13-12-25(18-26)14-16-27-17-15-25/h4-11,27,30H,12-18H2,1-3H3,(H,28,29)
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n/an/a 42n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


J Med Chem 58: 2465-88 (2015)


Article DOI: 10.1021/jm501940y
BindingDB Entry DOI: 10.7270/Q28C9XXK
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078181
PNG
(CHEMBL3417760)
Show SMILES ONC(=O)C1(CCC2(C1)CCNCC2)S(=O)(=O)c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C23H28N2O5S/c26-21(25-27)23(11-10-22(17-23)12-14-24-15-13-22)31(28,29)20-8-6-19(7-9-20)30-16-18-4-2-1-3-5-18/h1-9,24,27H,10-17H2,(H,25,26)
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n/an/a 54n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


J Med Chem 58: 2465-88 (2015)


Article DOI: 10.1021/jm501940y
BindingDB Entry DOI: 10.7270/Q28C9XXK
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078187
PNG
(CHEMBL3417754)
Show SMILES COc1ccc(Oc2ccc(cc2)S(=O)(=O)C2(CCC3(C2)CCNCC3)C(=O)NO)cn1
Show InChI InChI=1S/C22H27N3O6S/c1-30-19-7-4-17(14-24-19)31-16-2-5-18(6-3-16)32(28,29)22(20(26)25-27)9-8-21(15-22)10-12-23-13-11-21/h2-7,14,23,27H,8-13,15H2,1H3,(H,25,26)
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n/an/a 62n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


J Med Chem 58: 2465-88 (2015)


Article DOI: 10.1021/jm501940y
BindingDB Entry DOI: 10.7270/Q28C9XXK
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50204005
PNG
(CHEMBL3907007)
Show SMILES CC(C)C(CS(=O)(=O)c1ccc(cc1)-c1cccc(CNC(=O)c2nc3ccccc3c(=O)[nH]2)c1)N(O)C(C)=O
Show InChI InChI=1S/C29H30N4O6S/c1-18(2)26(33(37)19(3)34)17-40(38,39)23-13-11-21(12-14-23)22-8-6-7-20(15-22)16-30-29(36)27-31-25-10-5-4-9-24(25)28(35)32-27/h4-15,18,26,37H,16-17H2,1-3H3,(H,30,36)(H,31,32,35)
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n/an/a 64n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of recombinant human AMPA-activated MMP10 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate measured after 40 mins by spectrofluorimetric method


Bioorg Med Chem 24: 6149-6165 (2016)


Article DOI: 10.1016/j.bmc.2016.09.009
BindingDB Entry DOI: 10.7270/Q2H1341V
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078180
PNG
(CHEMBL3417761)
Show SMILES CNC(=O)c1ccc(COc2ccc(cc2)S(=O)(=O)C2(CCC3(C2)CCNCC3)C(=O)NO)cc1
Show InChI InChI=1S/C25H31N3O6S/c1-26-22(29)19-4-2-18(3-5-19)16-34-20-6-8-21(9-7-20)35(32,33)25(23(30)28-31)11-10-24(17-25)12-14-27-15-13-24/h2-9,27,31H,10-17H2,1H3,(H,26,29)(H,28,30)
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n/an/a 68n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


J Med Chem 58: 2465-88 (2015)


Article DOI: 10.1021/jm501940y
BindingDB Entry DOI: 10.7270/Q28C9XXK
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078200
PNG
(CHEMBL3417741)
Show SMILES COc1ccc(cc1)S(=O)(=O)C1(CCC2(C1)CCNCC2)C(=O)NO
Show InChI InChI=1S/C17H24N2O5S/c1-24-13-2-4-14(5-3-13)25(22,23)17(15(20)19-21)7-6-16(12-17)8-10-18-11-9-16/h2-5,18,21H,6-12H2,1H3,(H,19,20)
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n/an/a 84n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


J Med Chem 58: 2465-88 (2015)


Article DOI: 10.1021/jm501940y
BindingDB Entry DOI: 10.7270/Q28C9XXK
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078184
PNG
(CHEMBL3417757)
Show SMILES CNC(=O)c1cccc(Oc2ccc(cc2)S(=O)(=O)C2(CCC3(C2)CCNCC3)C(=O)NO)c1
Show InChI InChI=1S/C24H29N3O6S/c1-25-21(28)17-3-2-4-19(15-17)33-18-5-7-20(8-6-18)34(31,32)24(22(29)27-30)10-9-23(16-24)11-13-26-14-12-23/h2-8,15,26,30H,9-14,16H2,1H3,(H,25,28)(H,27,29)
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n/an/a 89n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


J Med Chem 58: 2465-88 (2015)


Article DOI: 10.1021/jm501940y
BindingDB Entry DOI: 10.7270/Q28C9XXK
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078173
PNG
(CHEMBL3417768)
Show SMILES CNC(=O)c1ccc(cc1)C(=O)Oc1ccc(cc1)S(=O)(=O)C1(CCC2(C1)CCNCC2)C(=O)NO
Show InChI InChI=1S/C25H29N3O7S/c1-26-21(29)17-2-4-18(5-3-17)22(30)35-19-6-8-20(9-7-19)36(33,34)25(23(31)28-32)11-10-24(16-25)12-14-27-15-13-24/h2-9,27,32H,10-16H2,1H3,(H,26,29)(H,28,31)
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n/an/a 103n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


J Med Chem 58: 2465-88 (2015)


Article DOI: 10.1021/jm501940y
BindingDB Entry DOI: 10.7270/Q28C9XXK
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50203955
PNG
(CHEMBL3978380)
Show SMILES O=C(NCc1cccc(c1)-c1ccc(CS(=O)(=O)Cc2n[nH]c(=O)[nH]2)cc1)c1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C26H22N6O5S/c33-24-20-6-1-2-7-21(20)28-23(30-24)25(34)27-13-17-4-3-5-19(12-17)18-10-8-16(9-11-18)14-38(36,37)15-22-29-26(35)32-31-22/h1-12H,13-15H2,(H,27,34)(H,28,30,33)(H2,29,31,32,35)
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n/an/a 150n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of recombinant human AMPA-activated MMP10 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate measured after 40 mins by spectrofluorimetric method


Bioorg Med Chem 24: 6149-6165 (2016)


Article DOI: 10.1016/j.bmc.2016.09.009
BindingDB Entry DOI: 10.7270/Q2H1341V
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50102750
PNG
(CHEMBL3359091)
Show SMILES COc1cccc(CNC(=O)c2nc3ccc(F)c(OCCc4ccc(cc4)C(O)=O)c3c(=O)[nH]2)c1
Show InChI InChI=1S/C26H22FN3O6/c1-35-18-4-2-3-16(13-18)14-28-25(32)23-29-20-10-9-19(27)22(21(20)24(31)30-23)36-12-11-15-5-7-17(8-6-15)26(33)34/h2-10,13H,11-12,14H2,1H3,(H,28,32)(H,33,34)(H,29,30,31)
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n/an/a 160n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP10 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate after 40 mins by spectrofluorimetry


J Med Chem 57: 8886-902 (2014)


Article DOI: 10.1021/jm500981k
BindingDB Entry DOI: 10.7270/Q28P628P
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50025160
PNG
(CHEMBL3337894)
Show SMILES COc1cccc(CNC(=O)c2nc3scc(COCc4ccc(cc4)C(O)=O)c3c(=O)[nH]2)c1
Show InChI InChI=1S/C24H21N3O6S/c1-32-18-4-2-3-15(9-18)10-25-22(29)20-26-21(28)19-17(13-34-23(19)27-20)12-33-11-14-5-7-16(8-6-14)24(30)31/h2-9,13H,10-12H2,1H3,(H,25,29)(H,30,31)(H,26,27,28)
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n/an/a 160n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP10 using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assay


Bioorg Med Chem 22: 5487-505 (2014)


Article DOI: 10.1016/j.bmc.2014.07.025
BindingDB Entry DOI: 10.7270/Q27S7QBJ
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50102750
PNG
(CHEMBL3359091)
Show SMILES COc1cccc(CNC(=O)c2nc3ccc(F)c(OCCc4ccc(cc4)C(O)=O)c3c(=O)[nH]2)c1
Show InChI InChI=1S/C26H22FN3O6/c1-35-18-4-2-3-16(13-18)14-28-25(32)23-29-20-10-9-19(27)22(21(20)24(31)30-23)36-12-11-15-5-7-17(8-6-15)26(33)34/h2-10,13H,11-12,14H2,1H3,(H,28,32)(H,33,34)(H,29,30,31)
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PubMed
n/an/a 160n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of recombinant human AMPA-activated MMP10 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate measured after 40 mins by spectrofluorimetric method


Bioorg Med Chem 24: 6149-6165 (2016)


Article DOI: 10.1016/j.bmc.2016.09.009
BindingDB Entry DOI: 10.7270/Q2H1341V
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078194
PNG
(CHEMBL3417747)
Show SMILES ONC(=O)C1(CCC2(C1)CCNCC2)S(=O)(=O)c1ccc(NCc2ccc(OC(F)(F)F)cc2)cc1
Show InChI InChI=1S/C24H28F3N3O5S/c25-24(26,27)35-19-5-1-17(2-6-19)15-29-18-3-7-20(8-4-18)36(33,34)23(21(31)30-32)10-9-22(16-23)11-13-28-14-12-22/h1-8,28-29,32H,9-16H2,(H,30,31)
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PubMed
n/an/a 184n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


J Med Chem 58: 2465-88 (2015)


Article DOI: 10.1021/jm501940y
BindingDB Entry DOI: 10.7270/Q28C9XXK
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078198
PNG
(CHEMBL3417743)
Show SMILES COc1ccc(Oc2cccc(c2)S(=O)(=O)C2(CCC3(C2)CCNCC3)C(=O)NO)cc1
Show InChI InChI=1S/C23H28N2O6S/c1-30-17-5-7-18(8-6-17)31-19-3-2-4-20(15-19)32(28,29)23(21(26)25-27)10-9-22(16-23)11-13-24-14-12-22/h2-8,15,24,27H,9-14,16H2,1H3,(H,25,26)
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n/an/a 189n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


J Med Chem 58: 2465-88 (2015)


Article DOI: 10.1021/jm501940y
BindingDB Entry DOI: 10.7270/Q28C9XXK
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50204001
PNG
(CHEMBL3894181)
Show SMILES O=C(NCc1cccc(OCCCOc2nc[nH]n2)c1)c1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C21H20N6O4/c28-19-16-7-1-2-8-17(16)25-18(26-19)20(29)22-12-14-5-3-6-15(11-14)30-9-4-10-31-21-23-13-24-27-21/h1-3,5-8,11,13H,4,9-10,12H2,(H,22,29)(H,23,24,27)(H,25,26,28)
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n/an/a 220n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of recombinant human AMPA-activated MMP10 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate measured after 40 mins by spectrofluorimetric method


Bioorg Med Chem 24: 6149-6165 (2016)


Article DOI: 10.1016/j.bmc.2016.09.009
BindingDB Entry DOI: 10.7270/Q2H1341V
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50203954
PNG
(CHEMBL3960062)
Show SMILES OC(=O)C1CCCCN1S(=O)(=O)CCCOc1cccc(CNC(=O)c2nc3ccccc3c(=O)[nH]2)c1
Show InChI InChI=1S/C25H28N4O7S/c30-23-19-9-1-2-10-20(19)27-22(28-23)24(31)26-16-17-7-5-8-18(15-17)36-13-6-14-37(34,35)29-12-4-3-11-21(29)25(32)33/h1-2,5,7-10,15,21H,3-4,6,11-14,16H2,(H,26,31)(H,32,33)(H,27,28,30)
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n/an/a 240n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of recombinant human AMPA-activated MMP10 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate measured after 40 mins by spectrofluorimetric method


Bioorg Med Chem 24: 6149-6165 (2016)


Article DOI: 10.1016/j.bmc.2016.09.009
BindingDB Entry DOI: 10.7270/Q2H1341V
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078179
PNG
(CHEMBL3417762)
Show SMILES ONC(=O)C1(CCC2(C1)CCNCC2)S(=O)(=O)c1ccc(OCCN2CCCC2=O)cc1
Show InChI InChI=1S/C22H31N3O6S/c26-19-2-1-13-25(19)14-15-31-17-3-5-18(6-4-17)32(29,30)22(20(27)24-28)8-7-21(16-22)9-11-23-12-10-21/h3-6,23,28H,1-2,7-16H2,(H,24,27)
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n/an/a 435n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


J Med Chem 58: 2465-88 (2015)


Article DOI: 10.1021/jm501940y
BindingDB Entry DOI: 10.7270/Q28C9XXK
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50204008
PNG
(CHEMBL3950850)
Show SMILES O=C(Cc1c[nH]cn1)N1CCN(CC1)c1cccc(CNC(=O)c2nc3ccccc3c(=O)[nH]2)c1
Show InChI InChI=1S/C25H25N7O3/c33-22(13-18-15-26-16-28-18)32-10-8-31(9-11-32)19-5-3-4-17(12-19)14-27-25(35)23-29-21-7-2-1-6-20(21)24(34)30-23/h1-7,12,15-16H,8-11,13-14H2,(H,26,28)(H,27,35)(H,29,30,34)
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PubMed
n/an/a 460n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of recombinant human AMPA-activated MMP10 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate measured after 40 mins by spectrofluorimetric method


Bioorg Med Chem 24: 6149-6165 (2016)


Article DOI: 10.1016/j.bmc.2016.09.009
BindingDB Entry DOI: 10.7270/Q2H1341V
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50203960
PNG
(CHEMBL3892938)
Show SMILES O=C(Cc1nnn[nH]1)N1CCN(CC1)c1cccc(CNC(=O)c2nc3ccccc3c(=O)[nH]2)c1
Show InChI InChI=1S/C23H23N9O3/c33-20(13-19-27-29-30-28-19)32-10-8-31(9-11-32)16-5-3-4-15(12-16)14-24-23(35)21-25-18-7-2-1-6-17(18)22(34)26-21/h1-7,12H,8-11,13-14H2,(H,24,35)(H,25,26,34)(H,27,28,29,30)
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PubMed
n/an/a 640n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of recombinant human AMPA-activated MMP10 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate measured after 40 mins by spectrofluorimetric method


Bioorg Med Chem 24: 6149-6165 (2016)


Article DOI: 10.1016/j.bmc.2016.09.009
BindingDB Entry DOI: 10.7270/Q2H1341V
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078182
PNG
(CHEMBL3417759)
Show SMILES CNC(=O)c1ccc(Oc2ccc(cc2)S(=O)(=O)C2(CCC3(C2)CCNCC3)C(=O)NO)cc1OC
Show InChI InChI=1S/C25H31N3O7S/c1-26-22(29)20-8-5-18(15-21(20)34-2)35-17-3-6-19(7-4-17)36(32,33)25(23(30)28-31)10-9-24(16-25)11-13-27-14-12-24/h3-8,15,27,31H,9-14,16H2,1-2H3,(H,26,29)(H,28,30)
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n/an/a 713n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


J Med Chem 58: 2465-88 (2015)


Article DOI: 10.1021/jm501940y
BindingDB Entry DOI: 10.7270/Q28C9XXK
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50078185
PNG
(CHEMBL3417756)
Show SMILES COc1ccccc1Oc1ccc(cc1)S(=O)(=O)C1(CCC2(C1)CCNCC2)C(=O)NO
Show InChI InChI=1S/C23H28N2O6S/c1-30-19-4-2-3-5-20(19)31-17-6-8-18(9-7-17)32(28,29)23(21(26)25-27)11-10-22(16-23)12-14-24-15-13-22/h2-9,24,27H,10-16H2,1H3,(H,25,26)
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n/an/a 739n/an/an/an/an/an/a



University of Navarra

Curated by ChEMBL


Assay Description
Inhibition of MMP-10 (unknown origin) measured every minute for 1 hr by fluorescence assay


J Med Chem 58: 2465-88 (2015)


Article DOI: 10.1021/jm501940y
BindingDB Entry DOI: 10.7270/Q28C9XXK
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50203958
PNG
(CHEMBL3965628)
Show SMILES Clc1cccc(c1)-c1csc2nc([nH]c(=O)c12)C(=O)NCc1cccc(OCCCOc2nc[nH]n2)c1
Show InChI InChI=1S/C25H21ClN6O4S/c26-17-6-2-5-16(11-17)19-13-37-24-20(19)22(33)30-21(31-24)23(34)27-12-15-4-1-7-18(10-15)35-8-3-9-36-25-28-14-29-32-25/h1-2,4-7,10-11,13-14H,3,8-9,12H2,(H,27,34)(H,28,29,32)(H,30,31,33)
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n/an/a 820n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of recombinant human AMPA-activated MMP10 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate measured after 40 mins by spectrofluorimetric method


Bioorg Med Chem 24: 6149-6165 (2016)


Article DOI: 10.1016/j.bmc.2016.09.009
BindingDB Entry DOI: 10.7270/Q2H1341V
More data for this
Ligand-Target Pair
Matrix metalloproteinase 10


(Homo sapiens (Human))
BDBM50204007
PNG
(CHEMBL3926071)
Show SMILES CCOCCC1(Oc2ccc(cc2)-c2cccc(CNC(=O)c3nc4ccccc4c(=O)[nH]3)c2)C(=O)NC(=O)NC1=O
Show InChI InChI=1S/C30H27N5O7/c1-2-41-15-14-30(27(38)34-29(40)35-28(30)39)42-21-12-10-19(11-13-21)20-7-5-6-18(16-20)17-31-26(37)24-32-23-9-4-3-8-22(23)25(36)33-24/h3-13,16H,2,14-15,17H2,1H3,(H,31,37)(H,32,33,36)(H2,34,35,38,39,40)
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PubMed
n/an/a 930n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of recombinant human AMPA-activated MMP10 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate measured after 40 mins by spectrofluorimetric method


Bioorg Med Chem 24: 6149-6165 (2016)


Article DOI: 10.1016/j.bmc.2016.09.009
BindingDB Entry DOI: 10.7270/Q2H1341V
More data for this
Ligand-Target Pair
Matrix Metalloproteinase-10 (MMP-10)


(Homo sapiens (Human))
BDBM26791
PNG
(benzimidazole analog., 17 | tert-butyl (3S,4S)-3-(...)
Show SMILES Cc1nc2ccccc2n1Cc1ccc(cc1)C(=O)N[C@@H]1CN(C[C@@H]1C(=O)NO)C(=O)OC(C)(C)C
Show InChI InChI=1S/C26H31N5O5/c1-16-27-20-7-5-6-8-22(20)31(16)13-17-9-11-18(12-10-17)23(32)28-21-15-30(14-19(21)24(33)29-35)25(34)36-26(2,3)4/h5-12,19,21,35H,13-15H2,1-4H3,(H,28,32)(H,29,33)/t19-,21+/m0/s1
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PubMed
n/an/a 1.60E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...


Bioorg Med Chem Lett 18: 1577-82 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.075
BindingDB Entry DOI: 10.7270/Q2GM85NS
More data for this
Ligand-Target Pair
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