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Compile Data Set for Download or QSAR

Found 17 hits Enz. Inhib. hit(s) with Target = 'Matrix metalloproteinase 26'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Matrix metalloproteinase 26


(Homo sapiens)
BDBM50062351
PNG
((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)
Show SMILES CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)CC(=O)NO
Show InChI InChI=1S/C20H28N4O4/c1-12(2)8-13(10-18(25)24-28)19(26)23-17(20(27)21-3)9-14-11-22-16-7-5-4-6-15(14)16/h4-7,11-13,17,22,28H,8-10H2,1-3H3,(H,21,27)(H,23,26)(H,24,25)/t13-,17+/m1/s1
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n/an/a 17n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory activity against MMP26


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase 26


(Homo sapiens)
BDBM50062351
PNG
((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)
Show SMILES CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)CC(=O)NO
Show InChI InChI=1S/C20H28N4O4/c1-12(2)8-13(10-18(25)24-28)19(26)23-17(20(27)21-3)9-14-11-22-16-7-5-4-6-15(14)16/h4-7,11-13,17,22,28H,8-10H2,1-3H3,(H,21,27)(H,23,26)(H,24,25)/t13-,17+/m1/s1
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n/an/a 17n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of matrix metalloproteinase-26 (MMP-26)


Bioorg Med Chem Lett 14: 47-50 (2003)

More data for this
Ligand-Target Pair
Matrix metalloproteinase 26


(Homo sapiens)
BDBM50137276
PNG
(6-Hydroxy-7-methoxy-2-(4-methoxy-benzenesulfonyl)-...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N1CCc2cc(O)c(OC)cc2C1C(=O)NO
Show InChI InChI=1S/C18H20N2O7S/c1-26-12-3-5-13(6-4-12)28(24,25)20-8-7-11-9-15(21)16(27-2)10-14(11)17(20)18(22)19-23/h3-6,9-10,17,21,23H,7-8H2,1-2H3,(H,19,22)
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n/an/a 86n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of matrix metalloproteinase-26 (MMP-26)


Bioorg Med Chem Lett 14: 47-50 (2003)

More data for this
Ligand-Target Pair
Matrix metalloproteinase 26


(Homo sapiens)
BDBM50137282
PNG
(6-Hydroxy-2-(toluene-4-sulfonyl)-1,2,3,4-tetrahydr...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N1CCc2cc(O)ccc2C1C(=O)NO
Show InChI InChI=1S/C17H18N2O5S/c1-11-2-5-14(6-3-11)25(23,24)19-9-8-12-10-13(20)4-7-15(12)16(19)17(21)18-22/h2-7,10,16,20,22H,8-9H2,1H3,(H,18,21)
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n/an/a 97n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of matrix metalloproteinase-26 (MMP-26)


Bioorg Med Chem Lett 14: 47-50 (2003)

More data for this
Ligand-Target Pair
Matrix metalloproteinase 26


(Homo sapiens)
BDBM50137281
PNG
(2-Benzenesulfonyl-6-hydroxy-7-methoxy-1,2,3,4-tetr...)
Show SMILES COc1cc2C(N(CCc2cc1O)S(=O)(=O)c1ccccc1)C(=O)NO
Show InChI InChI=1S/C17H18N2O6S/c1-25-15-10-13-11(9-14(15)20)7-8-19(16(13)17(21)18-22)26(23,24)12-5-3-2-4-6-12/h2-6,9-10,16,20,22H,7-8H2,1H3,(H,18,21)
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n/an/a 146n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of matrix metalloproteinase-26 (MMP-26)


Bioorg Med Chem Lett 14: 47-50 (2003)

More data for this
Ligand-Target Pair
Matrix metalloproteinase 26


(Homo sapiens)
BDBM50137277
PNG
(2-(4-Amino-benzenesulfonyl)-6-hydroxy-1,2,3,4-tetr...)
Show SMILES Nc1ccc(cc1)S(=O)(=O)N1CCc2cc(O)ccc2C1C(=O)NO
Show InChI InChI=1S/C16H17N3O5S/c17-11-1-4-13(5-2-11)25(23,24)19-8-7-10-9-12(20)3-6-14(10)15(19)16(21)18-22/h1-6,9,15,20,22H,7-8,17H2,(H,18,21)
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n/an/a 492n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of matrix metalloproteinase-26 (MMP-26)


Bioorg Med Chem Lett 14: 47-50 (2003)

More data for this
Ligand-Target Pair
Matrix metalloproteinase 26


(Homo sapiens)
BDBM50137283
PNG
(6-(benzyloxy)-N-hydroxy-2-(4-methoxyphenylsulfonyl...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NO
Show InChI InChI=1S/C24H24N2O6S/c1-31-19-7-10-21(11-8-19)33(29,30)26-14-13-18-15-20(32-16-17-5-3-2-4-6-17)9-12-22(18)23(26)24(27)25-28/h2-12,15,23,28H,13-14,16H2,1H3,(H,25,27)
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n/an/a 744n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of matrix metalloproteinase-26 (MMP-26)


Bioorg Med Chem Lett 14: 47-50 (2003)

More data for this
Ligand-Target Pair
Matrix metalloproteinase 26


(Homo sapiens)
BDBM50137279
PNG
(6-Hydroxy-2-(4-nitro-benzenesulfonyl)-1,2,3,4-tetr...)
Show SMILES ONC(=O)C1N(CCc2cc(O)ccc12)S(=O)(=O)c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C16H15N3O7S/c20-12-3-6-14-10(9-12)7-8-18(15(14)16(21)17-22)27(25,26)13-4-1-11(2-5-13)19(23)24/h1-6,9,15,20,22H,7-8H2,(H,17,21)
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n/an/a 791n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of matrix metalloproteinase-26 (MMP-26)


Bioorg Med Chem Lett 14: 47-50 (2003)

More data for this
Ligand-Target Pair
Matrix metalloproteinase 26


(Homo sapiens)
BDBM50137284
PNG
(2-Benzenesulfonyl-6-hydroxy-1,2,3,4-tetrahydro-iso...)
Show SMILES ONC(=O)C1N(CCc2cc(O)ccc12)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C16H16N2O5S/c19-12-6-7-14-11(10-12)8-9-18(15(14)16(20)17-21)24(22,23)13-4-2-1-3-5-13/h1-7,10,15,19,21H,8-9H2,(H,17,20)
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n/an/a 858n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of matrix metalloproteinase-26 (MMP-26)


Bioorg Med Chem Lett 14: 47-50 (2003)

More data for this
Ligand-Target Pair
Matrix metalloproteinase 26


(Homo sapiens)
BDBM50137287
PNG
(2-Benzenesulfonyl-6-benzyloxy-1,2,3,4-tetrahydro-i...)
Show SMILES ONC(=O)C1N(CCc2cc(OCc3ccccc3)ccc12)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C23H22N2O5S/c26-23(24-27)22-21-12-11-19(30-16-17-7-3-1-4-8-17)15-18(21)13-14-25(22)31(28,29)20-9-5-2-6-10-20/h1-12,15,22,27H,13-14,16H2,(H,24,26)
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n/an/a 1.45E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of matrix metalloproteinase-26 (MMP-26)


Bioorg Med Chem Lett 14: 47-50 (2003)

More data for this
Ligand-Target Pair
Matrix metalloproteinase 26


(Homo sapiens)
BDBM50137285
PNG
(6-(benzyloxy)-N-hydroxy-2-tosyl-1,2,3,4-tetrahydro...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NO
Show InChI InChI=1S/C24H24N2O5S/c1-17-7-10-21(11-8-17)32(29,30)26-14-13-19-15-20(31-16-18-5-3-2-4-6-18)9-12-22(19)23(26)24(27)25-28/h2-12,15,23,28H,13-14,16H2,1H3,(H,25,27)
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n/an/a 2.05E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of matrix metalloproteinase-26 (MMP-26)


Bioorg Med Chem Lett 14: 47-50 (2003)

More data for this
Ligand-Target Pair
Matrix metalloproteinase 26


(Homo sapiens)
BDBM50137286
PNG
(6-Hydroxy-2-(4-methoxy-benzenesulfonyl)-1,2,3,4-te...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N1CCc2cc(O)ccc2C1C(=O)NO
Show InChI InChI=1S/C17H18N2O6S/c1-25-13-3-5-14(6-4-13)26(23,24)19-9-8-11-10-12(20)2-7-15(11)16(19)17(21)18-22/h2-7,10,16,20,22H,8-9H2,1H3,(H,18,21)
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n/an/a 7.51E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of matrix metalloproteinase-26 (MMP-26)


Bioorg Med Chem Lett 14: 47-50 (2003)

More data for this
Ligand-Target Pair
Matrix metalloproteinase 26


(Homo sapiens)
BDBM50137278
PNG
(2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4...)
Show SMILES ONC(=O)C1N(CCc2cc(O)ccc12)S(=O)(=O)c1cc(Cl)ccc1Cl
Show InChI InChI=1S/C16H14Cl2N2O5S/c17-10-1-4-13(18)14(8-10)26(24,25)20-6-5-9-7-11(21)2-3-12(9)15(20)16(22)19-23/h1-4,7-8,15,21,23H,5-6H2,(H,19,22)
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n/an/a 7.90E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of matrix metalloproteinase-26 (MMP-26)


Bioorg Med Chem Lett 14: 47-50 (2003)

More data for this
Ligand-Target Pair
Matrix metalloproteinase 26


(Homo sapiens)
BDBM50063917
PNG
((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)
Show SMILES CNC(=O)[C@@H](NC(=O)[C@H](CC(C)C)[C@H](O)C(=O)NO)C(C)(C)C
Show InChI InChI=1S/C15H29N3O5/c1-8(2)7-9(10(19)13(21)18-23)12(20)17-11(14(22)16-6)15(3,4)5/h8-11,19,23H,7H2,1-6H3,(H,16,22)(H,17,20)(H,18,21)/t9-,10+,11-/m1/s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length human recombinant MMP26 using MCA-Arg-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-Glu-Arg-NH2 as substrate preincubated for 60 mins followe...


J Med Chem 59: 313-27 (2016)

More data for this
Ligand-Target Pair
Matrix metalloproteinase 26


(Homo sapiens)
BDBM50180601
PNG
(3-(4-(2-phenylethynyl)benzoyl)pentanoic acid | CHE...)
Show SMILES CCC(CC(O)=O)C(=O)c1ccc(cc1)C#Cc1ccccc1
Show InChI InChI=1S/C20H18O3/c1-2-17(14-19(21)22)20(23)18-12-10-16(11-13-18)9-8-15-6-4-3-5-7-15/h3-7,10-13,17H,2,14H2,1H3,(H,21,22)
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n/an/a 1.81E+4n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory activity against MMP26


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase 26


(Homo sapiens)
BDBM50365344
PNG
(CHEMBL1956115)
Show SMILES C[C@@](CCc1ccc(cc1)-c1ccccc1)(C(=O)NO)S(C)(=O)=O
Show InChI InChI=1S/C18H21NO4S/c1-18(17(20)19-21,24(2,22)23)13-12-14-8-10-16(11-9-14)15-6-4-3-5-7-15/h3-11,21H,12-13H2,1-2H3,(H,19,20)/t18-/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP26


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase 26


(Homo sapiens)
BDBM50305842
PNG
(CHEMBL603656 | trans-4-((5-(2-(4-fluorobenzylcarba...)
Show SMILES Cc1cc(cc(n1)C(=O)NCc1ccc(F)cc1)-c1nnn(C[C@H]2CC[C@@H](CC2)C(O)=O)n1
Show InChI InChI=1S/C23H25FN6O3/c1-14-10-18(11-20(26-14)22(31)25-12-15-4-8-19(24)9-5-15)21-27-29-30(28-21)13-16-2-6-17(7-3-16)23(32)33/h4-5,8-11,16-17H,2-3,6-7,12-13H2,1H3,(H,25,31)(H,32,33)/t16-,17-
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>2.50E+4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of MMP26


Citation and Details
More data for this
Ligand-Target Pair