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Compile Data Set for Download or QSAR

Found 737 hits Enz. Inhib. hit(s) with Target = 'Matrix metalloproteinase-12 (MMP12)'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM50360965
PNG
(CHEMBL1935286)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(cc21)-c1ccc(Cl)o1)C(O)=O
Show InChI InChI=1S/C21H18ClNO6S/c1-11(2)20(21(24)25)23-30(26,27)13-4-5-14-15-9-12(16-7-8-19(22)29-16)3-6-17(15)28-18(14)10-13/h3-11,20,23H,1-2H3,(H,24,25)/t20-/m0/s1
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n/an/a 0.100n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP-12


Bioorg Med Chem Lett 22: 138-43 (2011)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM50360964
PNG
(CHEMBL1935285)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(cc21)-c1ccc(C)o1)C(O)=O
Show InChI InChI=1S/C22H21NO6S/c1-12(2)21(22(24)25)23-30(26,27)15-6-7-16-17-10-14(18-8-4-13(3)28-18)5-9-19(17)29-20(16)11-15/h4-12,21,23H,1-3H3,(H,24,25)/t21-/m0/s1
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n/an/a 0.100n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP-12


Bioorg Med Chem Lett 22: 138-43 (2011)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM50360967
PNG
(CHEMBL1935288)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(cc21)-c1ccc(C)s1)C(O)=O
Show InChI InChI=1S/C22H21NO5S2/c1-12(2)21(22(24)25)23-30(26,27)15-6-7-16-17-10-14(20-9-4-13(3)29-20)5-8-18(17)28-19(16)11-15/h4-12,21,23H,1-3H3,(H,24,25)/t21-/m0/s1
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n/an/a 0.200n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP-12


Bioorg Med Chem Lett 22: 138-43 (2011)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM50360966
PNG
(CHEMBL1935287)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(cc21)-c1cccs1)C(O)=O
Show InChI InChI=1S/C21H19NO5S2/c1-12(2)20(21(23)24)22-29(25,26)14-6-7-15-16-10-13(19-4-3-9-28-19)5-8-17(16)27-18(15)11-14/h3-12,20,22H,1-2H3,(H,23,24)/t20-/m0/s1
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n/an/a 0.200n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP-12


Bioorg Med Chem Lett 22: 138-43 (2011)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM50161330
PNG
((R)-2-[(Biphenyl-4-sulfonyl)-isopropoxy-amino]-N-h...)
Show SMILES CC(C)ON([C@H](C(C)C)C(=O)NO)S(=O)(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C20H26N2O5S/c1-14(2)19(20(23)21-24)22(27-15(3)4)28(25,26)18-12-10-17(11-13-18)16-8-6-5-7-9-16/h5-15,19,24H,1-4H3,(H,21,23)/t19-/m1/s1
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n/an/a 0.200n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Inhibition of autoactivated human pro-MMP12 after 4 hrs by fluorimetry


J Med Chem 52: 6347-61 (2009)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM50299051
PNG
(CHEMBL573715 | N-Hydroxy-2-{2-[4-(4-methoxy-phenox...)
Show SMILES COc1ccc(Oc2ccc(cc2)S(=O)(=O)c2ccccc2CC(=O)NO)cc1
Show InChI InChI=1S/C21H19NO6S/c1-27-16-6-8-17(9-7-16)28-18-10-12-19(13-11-18)29(25,26)20-5-3-2-4-15(20)14-21(23)22-24/h2-13,24H,14H2,1H3,(H,22,23)
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n/an/a 0.200n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Inhibition of autoactivated human pro-MMP12 after 4 hrs by fluorimetry


J Med Chem 52: 6347-61 (2009)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM50148216
PNG
(4-[4-(4-Fluoro-phenoxy)-benzenesulfonylamino]-tetr...)
Show SMILES ONC(=O)C1(CCOCC1)NS(=O)(=O)c1ccc(Oc2ccc(F)cc2)cc1
Show InChI InChI=1S/C18H19FN2O6S/c19-13-1-3-14(4-2-13)27-15-5-7-16(8-6-15)28(24,25)21-18(17(22)20-23)9-11-26-12-10-18/h1-8,21,23H,9-12H2,(H,20,22)
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n/an/a 0.240n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of matrix metalloprotease-12


Bioorg Med Chem Lett 14: 3389-95 (2004)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM50360956
PNG
(CHEMBL1935304)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(cc21)-c1noc(n1)C1CCOC1)C(O)=O
Show InChI InChI=1S/C23H23N3O7S/c1-12(2)20(23(27)28)26-34(29,30)15-4-5-16-17-9-13(3-6-18(17)32-19(16)10-15)21-24-22(33-25-21)14-7-8-31-11-14/h3-6,9-10,12,14,20,26H,7-8,11H2,1-2H3,(H,27,28)/t14?,20-/m0/s1
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n/an/a 0.300n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP-12


Bioorg Med Chem Lett 22: 138-43 (2011)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM50215926
PNG
(4-(4,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]py...)
Show SMILES Nc1nc2c(nccc2[nH]1)-c1cc(Br)c(Br)[nH]1
Show InChI InChI=1S/C10H7Br2N5/c11-4-3-6(15-9(4)12)7-8-5(1-2-14-7)16-10(13)17-8/h1-3,15H,(H3,13,16,17)
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n/an/a 0.330n/an/an/an/an/an/a



Macquarie University

Curated by ChEMBL


Assay Description
Inhibition of MMP12


J Med Chem 54: 2492-503 (2011)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM50295489
PNG
((S)-2-(8-(Methoxycarbonylamino)dibenzo[b,d]thiophe...)
Show SMILES COC(=O)Nc1ccc2sc3cc(ccc3c2c1)S(=O)(=O)N[C@@H](C(C)C)C(O)=O
Show InChI InChI=1S/C19H20N2O6S2/c1-10(2)17(18(22)23)21-29(25,26)12-5-6-13-14-8-11(20-19(24)27-3)4-7-15(14)28-16(13)9-12/h4-10,17,21H,1-3H3,(H,20,24)(H,22,23)/t17-/m0/s1
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n/an/a 0.400n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP12


J Med Chem 52: 5408-19 (2009)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM50360968
PNG
(CHEMBL1935290)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(cc21)-c1ccc[nH]1)C(O)=O
Show InChI InChI=1S/C21H20N2O5S/c1-12(2)20(21(24)25)23-29(26,27)14-6-7-15-16-10-13(17-4-3-9-22-17)5-8-18(16)28-19(15)11-14/h3-12,20,22-23H,1-2H3,(H,24,25)/t20-/m0/s1
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n/an/a 0.400n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP-12


Bioorg Med Chem Lett 22: 138-43 (2011)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM50360963
PNG
(CHEMBL1935284)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(cc21)-c1ccoc1)C(O)=O
Show InChI InChI=1S/C21H19NO6S/c1-12(2)20(21(23)24)22-29(25,26)15-4-5-16-17-9-13(14-7-8-27-11-14)3-6-18(17)28-19(16)10-15/h3-12,20,22H,1-2H3,(H,23,24)/t20-/m0/s1
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n/an/a 0.400n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP-12


Bioorg Med Chem Lett 22: 138-43 (2011)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM50360959
PNG
(CHEMBL1935280)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(cc21)-n1ccc(n1)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C21H18F3N3O5S/c1-11(2)19(20(28)29)26-33(30,31)13-4-5-14-15-9-12(3-6-16(15)32-17(14)10-13)27-8-7-18(25-27)21(22,23)24/h3-11,19,26H,1-2H3,(H,28,29)/t19-/m0/s1
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n/an/a 0.700n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP-12


Bioorg Med Chem Lett 22: 138-43 (2011)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM50299051
PNG
(CHEMBL573715 | N-Hydroxy-2-{2-[4-(4-methoxy-phenox...)
Show SMILES COc1ccc(Oc2ccc(cc2)S(=O)(=O)c2ccccc2CC(=O)NO)cc1
Show InChI InChI=1S/C21H19NO6S/c1-27-16-6-8-17(9-7-16)28-18-10-12-19(13-11-18)29(25,26)20-5-3-2-4-15(20)14-21(23)22-24/h2-13,24H,14H2,1H3,(H,22,23)
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n/an/a 0.850n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Inhibition of autoactivated human pro-MMP12 after 1 hr preincubation by fluorometry


J Med Chem 52: 6347-61 (2009)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM50299051
PNG
(CHEMBL573715 | N-Hydroxy-2-{2-[4-(4-methoxy-phenox...)
Show SMILES COc1ccc(Oc2ccc(cc2)S(=O)(=O)c2ccccc2CC(=O)NO)cc1
Show InChI InChI=1S/C21H19NO6S/c1-27-16-6-8-17(9-7-16)28-18-10-12-19(13-11-18)29(25,26)20-5-3-2-4-15(20)14-21(23)22-24/h2-13,24H,14H2,1H3,(H,22,23)
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n/an/a 0.890n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Inhibition of autoactivated human pro-MMP12 after 30 mins preincubation by fluorometry


J Med Chem 52: 6347-61 (2009)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM28480
PNG
((2S)-3-methyl-2-({12-[(thiophen-3-ylcarbamoyl)amin...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(NC(=O)Nc3ccsc3)cc21)C(O)=O
Show InChI InChI=1S/C22H21N3O6S2/c1-12(2)20(21(26)27)25-33(29,30)15-4-5-16-17-9-13(3-6-18(17)31-19(16)10-15)23-22(28)24-14-7-8-32-11-14/h3-12,20,25H,1-2H3,(H,26,27)(H2,23,24,28)/t20-/m0/s1
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n/an/a 0.900n/an/an/an/a7.522



Wyeth Research



Assay Description
The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...


J Med Chem 52: 1799-802 (2009)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM50428828
PNG
(CHEMBL2337131)
Show SMILES ONC(=O)C1N(CCc2cc(Oc3ccccc3)ccc12)S(=O)(=O)c1cc(Cl)ccc1Cl
Show InChI InChI=1S/C22H18Cl2N2O5S/c23-15-6-9-19(24)20(13-15)32(29,30)26-11-10-14-12-17(31-16-4-2-1-3-5-16)7-8-18(14)21(26)22(27)25-28/h1-9,12-13,21,28H,10-11H2,(H,25,27)
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n/an/a 0.930n/an/an/an/an/an/a



Indian Institute of Technology (BHU)

Curated by ChEMBL


Assay Description
Inhibition of MMP12 (unknown origin)


Eur J Med Chem 60: 89-100 (2013)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM50151732
PNG
(4-[4-(2,4-Dichloro-benzyloxy)-benzenesulfonyl]-3-h...)
Show SMILES ONC(=O)[C@@]1(O)COCC[C@H]1S(=O)(=O)c1ccc(OCc2ccc(Cl)cc2Cl)cc1
Show InChI InChI=1S/C19H19Cl2NO7S/c20-13-2-1-12(16(21)9-13)10-29-14-3-5-15(6-4-14)30(26,27)17-7-8-28-11-19(17,24)18(23)22-25/h1-6,9,17,24-25H,7-8,10-11H2,(H,22,23)/t17-,19-/m1/s1
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n/an/a 0.950n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of matrix metalloprotease 12


Bioorg Med Chem Lett 14: 4727-30 (2004)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM50062351
PNG
((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)
Show SMILES CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)CC(=O)NO
Show InChI InChI=1S/C20H28N4O4/c1-12(2)8-13(10-18(25)24-28)19(26)23-17(20(27)21-3)9-14-11-22-16-7-5-4-6-15(14)16/h4-7,11-13,17,22,28H,8-10H2,1-3H3,(H,21,27)(H,23,26)(H,24,25)/t13-,17+/m1/s1
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n/an/a 1n/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of MMP12 (unknown origin)


J Med Chem 51: 3449-59 (2008)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM50026624
PNG
(CHEMBL1935289)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(cc21)-c1cc[nH]n1)C(O)=O
Show InChI InChI=1/C20H19N3O5S/c1-11(2)19(20(24)25)23-29(26,27)13-4-5-14-15-9-12(16-7-8-21-22-16)3-6-17(15)28-18(14)10-13/h3-11,19,23H,1-2H3,(H,21,22)(H,24,25)/t19-/s2
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n/an/a<1n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP-12


Bioorg Med Chem Lett 22: 138-43 (2011)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM50360969
PNG
(CHEMBL1935291)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(cc21)-c1nccs1)C(O)=O
Show InChI InChI=1S/C20H18N2O5S2/c1-11(2)18(20(23)24)22-29(25,26)13-4-5-14-15-9-12(19-21-7-8-28-19)3-6-16(15)27-17(14)10-13/h3-11,18,22H,1-2H3,(H,23,24)/t18-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP-12


Bioorg Med Chem Lett 22: 138-43 (2011)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM28481
PNG
((2S)-3-methyl-2-{[12-({[2-(thiophen-2-yl)ethyl]car...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(NC(=O)NCCc3cccs3)cc21)C(O)=O
Show InChI InChI=1S/C24H25N3O6S2/c1-14(2)22(23(28)29)27-35(31,32)17-6-7-18-19-12-15(5-8-20(19)33-21(18)13-17)26-24(30)25-10-9-16-4-3-11-34-16/h3-8,11-14,22,27H,9-10H2,1-2H3,(H,28,29)(H2,25,26,30)/t22-/m0/s1
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n/an/a 1.10n/an/an/an/a7.522



Wyeth Research



Assay Description
The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...


J Med Chem 52: 1799-802 (2009)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM50360970
PNG
(CHEMBL1935292)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(cc21)-c1ncc(C)s1)C(O)=O
Show InChI InChI=1S/C21H20N2O5S2/c1-11(2)19(21(24)25)23-30(26,27)14-5-6-15-16-8-13(20-22-10-12(3)29-20)4-7-17(16)28-18(15)9-14/h4-11,19,23H,1-3H3,(H,24,25)/t19-/m0/s1
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n/an/a 1.20n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP-12


Bioorg Med Chem Lett 22: 138-43 (2011)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM50295479
PNG
((S)-3-Methyl-2-(8-(2-oxooxazolidin-3-yl)dibenzo[b,...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(cc21)N1CCOC1=O)C(O)=O
Show InChI InChI=1S/C20H20N2O7S/c1-11(2)18(19(23)24)21-30(26,27)13-4-5-14-15-9-12(22-7-8-28-20(22)25)3-6-16(15)29-17(14)10-13/h3-6,9-11,18,21H,7-8H2,1-2H3,(H,23,24)/t18-/m0/s1
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n/an/a 1.40n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP12


J Med Chem 52: 5408-19 (2009)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM92442
PNG
(MMP Inhibitor, 2)
Show SMILES CC(C)C(NS(=O)(=O)c1ccc2c(c1)oc1ccc(cc21)N1CCOC1=O)C(O)=O
Show InChI InChI=1S/C20H20N2O7S/c1-11(2)18(19(23)24)21-30(26,27)13-4-5-14-15-9-12(22-7-8-28-20(22)25)3-6-16(15)29-17(14)10-13/h3-6,9-11,18,21H,7-8H2,1-2H3,(H,23,24)
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n/an/a 1.40n/an/an/an/a6.825



Commissariat á l'Energie Atomique



Assay Description
Enzyme assay using human matrix metalloproteases or ADAMTS.


J Biol Chem 287: 26647-56 (2012)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM50360952
PNG
(CHEMBL1935300)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(cc21)-c1noc(n1)C1CC1)C(O)=O
Show InChI InChI=1S/C22H21N3O6S/c1-11(2)19(22(26)27)25-32(28,29)14-6-7-15-16-9-13(5-8-17(16)30-18(15)10-14)20-23-21(31-24-20)12-3-4-12/h5-12,19,25H,3-4H2,1-2H3,(H,26,27)/t19-/m0/s1
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n/an/a 1.60n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP-12


Bioorg Med Chem Lett 22: 138-43 (2011)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM50129986
PNG
((4-Benzyl-benzyl)-[4-(4-chloro-phenyl)-2-((S)-2,2-...)
Show SMILES CNC(=O)[C@@H](NC(=O)C(CCc1ccc(Cl)cc1)CP(O)(=O)Cc1ccc(Cc2ccccc2)cc1)C(C)(C)C
Show InChI InChI=1S/C32H40ClN2O4P/c1-32(2,3)29(31(37)34-4)35-30(36)27(17-14-23-15-18-28(33)19-16-23)22-40(38,39)21-26-12-10-25(11-13-26)20-24-8-6-5-7-9-24/h5-13,15-16,18-19,27,29H,14,17,20-22H2,1-4H3,(H,34,37)(H,35,36)(H,38,39)/t27?,29-/m1/s1
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n/an/a 1.70n/an/an/an/an/an/a



Pomona College

Curated by ChEMBL


Assay Description
Inhibition of MMP12


Bioorg Med Chem 15: 2223-68 (2007)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM50129986
PNG
((4-Benzyl-benzyl)-[4-(4-chloro-phenyl)-2-((S)-2,2-...)
Show SMILES CNC(=O)[C@@H](NC(=O)C(CCc1ccc(Cl)cc1)CP(O)(=O)Cc1ccc(Cc2ccccc2)cc1)C(C)(C)C
Show InChI InChI=1S/C32H40ClN2O4P/c1-32(2,3)29(31(37)34-4)35-30(36)27(17-14-23-15-18-28(33)19-16-23)22-40(38,39)21-26-12-10-25(11-13-26)20-24-8-6-5-7-9-24/h5-13,15-16,18-19,27,29H,14,17,20-22H2,1-4H3,(H,34,37)(H,35,36)(H,38,39)/t27?,29-/m1/s1
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n/an/a 1.70n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of matrix metalloprotease-12


Bioorg Med Chem Lett 13: 2331-6 (2003)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM50295488
PNG
((R)-2-(8-(Methoxycarbonylamino)dibenzo[b,d]thiophe...)
Show SMILES COC(=O)Nc1ccc2sc3cc(ccc3c2c1)S(=O)(=O)N[C@H](C(C)C)C(O)=O
Show InChI InChI=1S/C19H20N2O6S2/c1-10(2)17(18(22)23)21-29(25,26)12-5-6-13-14-8-11(20-19(24)27-3)4-7-15(14)28-16(13)9-12/h4-10,17,21H,1-3H3,(H,20,24)(H,22,23)/t17-/m1/s1
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n/an/a 1.80n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP12


J Med Chem 52: 5408-19 (2009)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM50360950
PNG
(CHEMBL1935298)
Show SMILES COCc1nc(no1)-c1ccc2oc3cc(ccc3c2c1)S(=O)(=O)N[C@@H](C(C)C)C(O)=O
Show InChI InChI=1S/C21H21N3O7S/c1-11(2)19(21(25)26)24-32(27,28)13-5-6-14-15-8-12(4-7-16(15)30-17(14)9-13)20-22-18(10-29-3)31-23-20/h4-9,11,19,24H,10H2,1-3H3,(H,25,26)/t19-/m0/s1
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n/an/a 1.90n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP-12


Bioorg Med Chem Lett 22: 138-43 (2011)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM28469
PNG
((2S)-2-({12-[(methoxycarbonyl)amino]-8-oxatricyclo...)
Show SMILES COC(=O)Nc1ccc2oc3cc(ccc3c2c1)S(=O)(=O)N[C@@H](C(C)C)C(O)=O
Show InChI InChI=1S/C19H20N2O7S/c1-10(2)17(18(22)23)21-29(25,26)12-5-6-13-14-8-11(20-19(24)27-3)4-7-15(14)28-16(13)9-12/h4-10,17,21H,1-3H3,(H,20,24)(H,22,23)/t17-/m0/s1
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n/an/a 2n/an/an/an/a7.522



Wyeth Research



Assay Description
The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...


J Med Chem 52: 1799-802 (2009)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM50295479
PNG
((S)-3-Methyl-2-(8-(2-oxooxazolidin-3-yl)dibenzo[b,...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(cc21)N1CCOC1=O)C(O)=O
Show InChI InChI=1S/C20H20N2O7S/c1-11(2)18(19(23)24)21-30(26,27)13-4-5-14-15-9-12(22-7-8-28-20(22)25)3-6-16(15)29-17(14)10-13/h3-6,9-11,18,21H,7-8H2,1-2H3,(H,23,24)/t18-/m0/s1
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP-12


Bioorg Med Chem Lett 22: 138-43 (2011)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM28469
PNG
((2S)-2-({12-[(methoxycarbonyl)amino]-8-oxatricyclo...)
Show SMILES COC(=O)Nc1ccc2oc3cc(ccc3c2c1)S(=O)(=O)N[C@@H](C(C)C)C(O)=O
Show InChI InChI=1S/C19H20N2O7S/c1-10(2)17(18(22)23)21-29(25,26)12-5-6-13-14-8-11(20-19(24)27-3)4-7-15(14)28-16(13)9-12/h4-10,17,21H,1-3H3,(H,20,24)(H,22,23)/t17-/m0/s1
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n/an/a 2n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP12


J Med Chem 52: 5408-19 (2009)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM50035507
PNG
(CHEMBL3355722)
Show SMILES CC(C)C[C@H](CC(=O)NO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O
Show InChI InChI=1/C23H37N5O5/c1-15(2)12-17(14-20(29)28-33)22(31)27-19(13-16-8-4-3-5-9-16)23(32)26-18(21(25)30)10-6-7-11-24/h3-5,8-9,15,17-19,33H,6-7,10-14,24H2,1-2H3,(H2,25,30)(H,26,32)(H,27,31)(H,28,29)/t17-,18+,19+/s2
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n/an/a 2n/an/an/an/an/an/a



University Medical Center Groningen

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP12 catalytic domain Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 fluorogenic substrate


Bioorg Med Chem 23: 192-202 (2014)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM50437788
PNG
(CHEMBL2409699)
Show SMILES CCOc1ccc(OC2CCN(CC2)S(=O)(=O)C[C@@]2(C)NC(=O)NC2=O)cc1
Show InChI InChI=1S/C18H25N3O6S/c1-3-26-13-4-6-14(7-5-13)27-15-8-10-21(11-9-15)28(24,25)12-18(2)16(22)19-17(23)20-18/h4-7,15H,3,8-12H2,1-2H3,(H2,19,20,22,23)/t18-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of MMP-12 (unknown origin) by fluorescence assay


Bioorg Med Chem Lett 23: 4705-12 (2013)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM28473
PNG
((2S)-2-[(12-{[(2-fluoroethoxy)carbonyl]amino}-8-ox...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(NC(=O)OCCF)cc21)C(O)=O
Show InChI InChI=1S/C20H21FN2O7S/c1-11(2)18(19(24)25)23-31(27,28)13-4-5-14-15-9-12(22-20(26)29-8-7-21)3-6-16(15)30-17(14)10-13/h3-6,9-11,18,23H,7-8H2,1-2H3,(H,22,26)(H,24,25)/t18-/m0/s1
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n/an/a 2.10n/an/an/an/a7.522



Wyeth Research



Assay Description
The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...


J Med Chem 52: 1799-802 (2009)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM50360951
PNG
(CHEMBL1935299)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(cc21)-c1noc(n1)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C20H16F3N3O6S/c1-9(2)16(18(27)28)26-33(29,30)11-4-5-12-13-7-10(3-6-14(13)31-15(12)8-11)17-24-19(32-25-17)20(21,22)23/h3-9,16,26H,1-2H3,(H,27,28)/t16-/m0/s1
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n/an/a 2.20n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP-12


Bioorg Med Chem Lett 22: 138-43 (2011)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM50360962
PNG
(CHEMBL1935283)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(cc21)N1CCOCC1)C(O)=O
Show InChI InChI=1S/C21H24N2O6S/c1-13(2)20(21(24)25)22-30(26,27)15-4-5-16-17-11-14(23-7-9-28-10-8-23)3-6-18(17)29-19(16)12-15/h3-6,11-13,20,22H,7-10H2,1-2H3,(H,24,25)/t20-/m0/s1
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n/an/a 2.20n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP-12


Bioorg Med Chem Lett 22: 138-43 (2011)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM50360953
PNG
(CHEMBL1935301)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(cc21)-c1noc(n1)C1CCC1)C(O)=O
Show InChI InChI=1S/C23H23N3O6S/c1-12(2)20(23(27)28)26-33(29,30)15-7-8-16-17-10-14(6-9-18(17)31-19(16)11-15)21-24-22(32-25-21)13-4-3-5-13/h6-13,20,26H,3-5H2,1-2H3,(H,27,28)/t20-/m0/s1
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n/an/a 2.30n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP-12


Bioorg Med Chem Lett 22: 138-43 (2011)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM50131660
PNG
(CHEMBL118497 | Succinic acid mono-[4-hydroxycarbam...)
Show SMILES C[C@@H](C[C@@H](COC(=O)CCC(O)=O)NC(=O)c1ccc(Oc2ccccc2)cc1)C(=O)NO
Show InChI InChI=1S/C23H26N2O8/c1-15(22(29)25-31)13-17(14-32-21(28)12-11-20(26)27)24-23(30)16-7-9-19(10-8-16)33-18-5-3-2-4-6-18/h2-10,15,17,31H,11-14H2,1H3,(H,24,30)(H,25,29)(H,26,27)/t15-,17-/m0/s1
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n/an/a 2.60n/an/an/an/an/an/a



National Cardiovascular Center Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human Matrix metalloprotease-12 (MMP-12)


J Med Chem 46: 3497-501 (2003)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM50299056
PNG
((+/-)-N-Hydroxy-2-[2-(4'-methoxy-biphenyl-4-sulfon...)
Show SMILES COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)c1ccccc1C(C)C(=O)NO
Show InChI InChI=1S/C22H21NO5S/c1-15(22(24)23-25)20-5-3-4-6-21(20)29(26,27)19-13-9-17(10-14-19)16-7-11-18(28-2)12-8-16/h3-15,25H,1-2H3,(H,23,24)
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n/an/a 2.70n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Inhibition of autoactivated human pro-MMP12 after 4 hrs by fluorimetry


J Med Chem 52: 6347-61 (2009)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM50360972
PNG
(CHEMBL1935294)
Show SMILES CCc1nc(no1)-c1ccc2oc3cc(ccc3c2c1)S(=O)(=O)N[C@@H](C(C)C)C(O)=O
Show InChI InChI=1S/C21H21N3O6S/c1-4-18-22-20(23-30-18)12-5-8-16-15(9-12)14-7-6-13(10-17(14)29-16)31(27,28)24-19(11(2)3)21(25)26/h5-11,19,24H,4H2,1-3H3,(H,25,26)/t19-/m0/s1
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n/an/a 2.90n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP-12


Bioorg Med Chem Lett 22: 138-43 (2011)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM50437787
PNG
(CHEMBL2409700)
Show SMILES C[C@]1(CS(=O)(=O)N2CCC(CC2)Oc2ccc(OC(F)(F)F)cc2)NC(=O)NC1=O
Show InChI InChI=1S/C17H20F3N3O6S/c1-16(14(24)21-15(25)22-16)10-30(26,27)23-8-6-12(7-9-23)28-11-2-4-13(5-3-11)29-17(18,19)20/h2-5,12H,6-10H2,1H3,(H2,21,22,24,25)/t16-/m1/s1
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n/an/a 3.30n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of MMP-12 (unknown origin) by fluorescence assay


Bioorg Med Chem Lett 23: 4705-12 (2013)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM50131661
PNG
(CHEMBL116944 | N-(3-Hydroxycarbamoyl-1-hydroxymeth...)
Show SMILES C[C@@H](C[C@@H](CO)NC(=O)c1ccc(Oc2ccccc2)cc1)C(=O)NO
Show InChI InChI=1S/C19H22N2O5/c1-13(18(23)21-25)11-15(12-22)20-19(24)14-7-9-17(10-8-14)26-16-5-3-2-4-6-16/h2-10,13,15,22,25H,11-12H2,1H3,(H,20,24)(H,21,23)/t13-,15-/m0/s1
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n/an/a 3.5n/an/an/an/an/an/a



National Cardiovascular Center Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human Matrix metalloprotease-12 (MMP-12)


J Med Chem 46: 3497-501 (2003)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM50360955
PNG
(CHEMBL1935303)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(cc21)-c1noc(n1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C25H21N3O6S/c1-14(2)22(25(29)30)28-35(31,32)17-9-10-18-19-12-16(8-11-20(19)33-21(18)13-17)23-26-24(34-27-23)15-6-4-3-5-7-15/h3-14,22,28H,1-2H3,(H,29,30)/t22-/m0/s1
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n/an/a 4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP-12


Bioorg Med Chem Lett 22: 138-43 (2011)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM50129994
PNG
(2-(((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-...)
Show SMILES CNC(=O)[C@@H](NC(=O)C(CCc1ccccc1)CP(O)(=O)Cc1ccc(Cc2ccccc2OC)cc1)C(C)(C)C
Show InChI InChI=1S/C33H43N2O5P/c1-33(2,3)30(32(37)34-4)35-31(36)28(20-19-24-11-7-6-8-12-24)23-41(38,39)22-26-17-15-25(16-18-26)21-27-13-9-10-14-29(27)40-5/h6-18,28,30H,19-23H2,1-5H3,(H,34,37)(H,35,36)(H,38,39)/t28?,30-/m1/s1
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n/an/a 4n/an/an/an/an/an/a



Pomona College

Curated by ChEMBL


Assay Description
Inhibition of MMP12


Bioorg Med Chem 15: 2223-68 (2007)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM50129994
PNG
(2-(((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-...)
Show SMILES CNC(=O)[C@@H](NC(=O)C(CCc1ccccc1)CP(O)(=O)Cc1ccc(Cc2ccccc2OC)cc1)C(C)(C)C
Show InChI InChI=1S/C33H43N2O5P/c1-33(2,3)30(32(37)34-4)35-31(36)28(20-19-24-11-7-6-8-12-24)23-41(38,39)22-26-17-15-25(16-18-26)21-27-13-9-10-14-29(27)40-5/h6-18,28,30H,19-23H2,1-5H3,(H,34,37)(H,35,36)(H,38,39)/t28?,30-/m1/s1
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n/an/a 4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of matrix metalloprotease-12


Bioorg Med Chem Lett 13: 2331-6 (2003)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM50360947
PNG
(CHEMBL1935295)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(cc21)-c1noc(n1)C(C)C)C(O)=O
Show InChI InChI=1S/C22H23N3O6S/c1-11(2)19(22(26)27)25-32(28,29)14-6-7-15-16-9-13(5-8-17(16)30-18(15)10-14)20-23-21(12(3)4)31-24-20/h5-12,19,25H,1-4H3,(H,26,27)/t19-/m0/s1
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n/an/a 4.5n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP-12


Bioorg Med Chem Lett 22: 138-43 (2011)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM28472
PNG
((2S)-3-methyl-2-[(12-{[(2-methylpropoxy)carbonyl]a...)
Show SMILES CC(C)COC(=O)Nc1ccc2oc3cc(ccc3c2c1)S(=O)(=O)N[C@@H](C(C)C)C(O)=O
Show InChI InChI=1S/C22H26N2O7S/c1-12(2)11-30-22(27)23-14-5-8-18-17(9-14)16-7-6-15(10-19(16)31-18)32(28,29)24-20(13(3)4)21(25)26/h5-10,12-13,20,24H,11H2,1-4H3,(H,23,27)(H,25,26)/t20-/m0/s1
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n/an/a 4.70n/an/an/an/a7.522



Wyeth Research



Assay Description
The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...


J Med Chem 52: 1799-802 (2009)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM50299052
PNG
(CHEMBL584365 | N-Hydroxy-2-[2-(4'-methoxy-biphenyl...)
Show SMILES COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)c1ccccc1CC(=O)NO
Show InChI InChI=1S/C21H19NO5S/c1-27-18-10-6-15(7-11-18)16-8-12-19(13-9-16)28(25,26)20-5-3-2-4-17(20)14-21(23)22-24/h2-13,24H,14H2,1H3,(H,22,23)
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n/an/a 4.80n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Inhibition of autoactivated human pro-MMP12 after 4 hrs by fluorimetry


J Med Chem 52: 6347-61 (2009)

More data for this
Ligand-Target Pair
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