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Compile Data Set for Download or QSAR

Found 4304 hits Enz. Inhib. hit(s) with Target = 'Matrix metalloproteinase-2 (MMP-2)'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Matrix metalloproteinase-2 (MMP-2)


(homo sapiens (human))
BDBM12074
PNG
((2R)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-3-m...)
Show SMILES CC(C)[C@@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(Br)cc1)C(O)=O
Show InChI InChI=1S/C17H18BrNO4S/c1-11(2)16(17(20)21)19-24(22,23)15-9-5-13(6-10-15)12-3-7-14(18)8-4-12/h3-11,16,19H,1-2H3,(H,20,21)/t16-/m1/s1
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Article
PubMed
n/an/a 0.00400n/an/an/an/an/an/a



Indian Institute of Technology (BHU)

Curated by ChEMBL


Assay Description
Inhibition of MMP2 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(homo sapiens (human))
BDBM11863
PNG
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Show SMILES ONC(=O)C1(CS(=O)(=O)c2ccc(Oc3ccc(Cl)cc3)cc2)CCOCC1
Show InChI InChI=1S/C19H20ClNO6S/c20-14-1-3-15(4-2-14)27-16-5-7-17(8-6-16)28(24,25)13-19(18(22)21-23)9-11-26-12-10-19/h1-8,23H,9-13H2,(H,21,22)
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n/an/a 0.0290n/an/an/an/an/an/a



Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited , 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate after 40 mins by spectrofluorimetry


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(homo sapiens (human))
BDBM11863
PNG
(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Show SMILES ONC(=O)C1(CS(=O)(=O)c2ccc(Oc3ccc(Cl)cc3)cc2)CCOCC1
Show InChI InChI=1S/C19H20ClNO6S/c20-14-1-3-15(4-2-14)27-16-5-7-17(8-6-16)28(24,25)13-19(18(22)21-23)9-11-26-12-10-19/h1-8,23H,9-13H2,(H,21,22)
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n/an/a 0.0290n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(homo sapiens (human))
BDBM50175548
PNG
(CHEMBL198778 | N-Hydroxy-2-(4-phenoxy-benzenesulfo...)
Show SMILES ONC(=O)CNS(=O)(=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C14H14N2O5S/c17-14(16-18)10-15-22(19,20)13-8-6-12(7-9-13)21-11-4-2-1-3-5-11/h1-9,15,18H,10H2,(H,16,17)
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n/an/a 0.0400n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 using Mca-Lys-Pro- Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 2 hrs prior to substrate addition...


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(homo sapiens (human))
BDBM24025
PNG
((2R)-3-methyl-2-[(4-phenylbenzene)sulfonamido]buta...)
Show SMILES CC(C)[C@@H](NS(=O)(=O)c1ccc(cc1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C17H19NO4S/c1-12(2)16(17(19)20)18-23(21,22)15-10-8-14(9-11-15)13-6-4-3-5-7-13/h3-12,16,18H,1-2H3,(H,19,20)/t16-/m1/s1
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n/an/a 0.0400n/an/an/an/an/an/a



Indian Institute of Technology (BHU)

Curated by ChEMBL


Assay Description
Inhibition of MMP2 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(homo sapiens (human))
BDBM50082556
PNG
((S)-2,2-Dimethyl-4-[4-(pyridin-4-yloxy)-benzenesul...)
Show SMILES CC1(C)SCCN([C@H]1C(=O)NO)S(=O)(=O)c1ccc(Oc2ccncc2)cc1
Show InChI InChI=1S/C18H21N3O5S2/c1-18(2)16(17(22)20-23)21(11-12-27-18)28(24,25)15-5-3-13(4-6-15)26-14-7-9-19-10-8-14/h3-10,16,23H,11-12H2,1-2H3,(H,20,22)/t16-/m0/s1
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n/an/a 0.0480n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro selective inhibition against matrix metalloprotease-2 (MMP-2) using fluorimetric assay


J Med Chem 45: 219-32 (2001)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(homo sapiens (human))
BDBM50106026
PNG
((S)-2,2-Dimethyl-4-[4-(pyridin-3-yloxy)-benzenesul...)
Show SMILES CC1(C)SCCN([C@H]1C(=O)NO)S(=O)(=O)c1ccc(Oc2cccnc2)cc1
Show InChI InChI=1S/C18H21N3O5S2/c1-18(2)16(17(22)20-23)21(10-11-27-18)28(24,25)15-7-5-13(6-8-15)26-14-4-3-9-19-12-14/h3-9,12,16,23H,10-11H2,1-2H3,(H,20,22)/t16-/m0/s1
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n/an/a 0.0480n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against Matrix metalloproteinase-2


Bioorg Med Chem Lett 11: 2907-10 (2001)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(homo sapiens (human))
BDBM50131941
PNG
(2-(4'-Chloro-biphenyl-4-ylsulfanylmethyl)-N-hydrox...)
Show SMILES ONC(=O)C(CCn1nnc2ccccc2c1=O)CSc1ccc(cc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C24H21ClN4O3S/c25-19-9-5-16(6-10-19)17-7-11-20(12-8-17)33-15-18(23(30)27-32)13-14-29-24(31)21-3-1-2-4-22(21)26-28-29/h1-12,18,32H,13-15H2,(H,27,30)
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n/an/a 0.0600n/an/an/an/an/an/a



Institut de Recherches Servier

Curated by ChEMBL


Assay Description
Inhibitory activity against matrix metalloprotease-2 (MMP2)


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(homo sapiens (human))
BDBM50389101
PNG
(CHEMBL2064548)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1cn(CCOCCOCCOCCOS(=O)(=O)c2ccc(C)cc2)nn1)[C@H](C(C)C)C(=O)NO
Show InChI InChI=1S/C30H43N5O11S2/c1-23(2)29(30(36)32-37)35(47(38,39)27-11-7-26(42-4)8-12-27)22-25-21-34(33-31-25)13-14-43-15-16-44-17-18-45-19-20-46-48(40,41)28-9-5-24(3)6-10-28/h5-12,21,23,29,37H,13-20,22H2,1-4H3,(H,32,36)/t29-/m1/s1
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n/an/a 0.0700n/an/an/an/an/an/a



University Hospital M£nster

Curated by ChEMBL


Assay Description
Inhibition of MMP2 using (7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl)Ala-Arg-NH2 as substrate incuba...


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(homo sapiens (human))
BDBM50137279
PNG
(6-Hydroxy-2-(4-nitro-benzenesulfonyl)-1,2,3,4-tetr...)
Show SMILES ONC(=O)C1N(CCc2cc(O)ccc12)S(=O)(=O)c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C16H15N3O7S/c20-12-3-6-14-10(9-12)7-8-18(15(14)16(21)17-22)27(25,26)13-4-1-11(2-5-13)19(23)24/h1-6,9,15,20,22H,7-8H2,(H,17,21)
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n/an/a 0.0760n/an/an/an/an/an/a



Indian Institute of Technology (BHU)

Curated by ChEMBL


Assay Description
Inhibition of MMP2 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(homo sapiens (human))
BDBM50161330
PNG
((R)-2-[(Biphenyl-4-sulfonyl)-isopropoxy-amino]-N-h...)
Show SMILES CC(C)ON([C@H](C(C)C)C(=O)NO)S(=O)(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C20H26N2O5S/c1-14(2)19(20(23)21-24)22(27-15(3)4)28(25,26)18-12-10-17(11-13-18)16-8-6-5-7-9-16/h5-15,19,24H,1-4H3,(H,21,23)/t19-/m1/s1
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n/an/a 0.0900n/an/an/an/an/an/a



Universit£ degli Studi di Pisa

Curated by ChEMBL


Assay Description
Inhibition of human matrix metalloprotease-2


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(homo sapiens (human))
BDBM50082556
PNG
((S)-2,2-Dimethyl-4-[4-(pyridin-4-yloxy)-benzenesul...)
Show SMILES CC1(C)SCCN([C@H]1C(=O)NO)S(=O)(=O)c1ccc(Oc2ccncc2)cc1
Show InChI InChI=1S/C18H21N3O5S2/c1-18(2)16(17(22)20-23)21(11-12-27-18)28(24,25)15-5-3-13(4-6-15)26-14-7-9-19-10-8-14/h3-10,16,23H,11-12H2,1-2H3,(H,20,22)/t16-/m0/s1
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n/an/a 0.0900n/an/an/an/an/an/a



Universit£ degli Studi di Pisa

Curated by ChEMBL


Assay Description
Inhibition of human matrix metalloprotease-2


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(homo sapiens (human))
BDBM50108135
PNG
(2-(Formyl-hydroxy-amino)-3-[4-(4-trifluoromethoxy-...)
Show SMILES CN(C)S(=O)(=O)CC(CS(=O)(=O)c1ccc(Oc2ccc(OC(F)(F)F)cc2)cc1)N(O)C=O
Show InChI InChI=1S/C19H21F3N2O8S2/c1-23(2)34(29,30)12-14(24(26)13-25)11-33(27,28)18-9-7-16(8-10-18)31-15-3-5-17(6-4-15)32-19(20,21)22/h3-10,13-14,26H,11-12H2,1-2H3
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n/an/a 0.0980n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro selective inhibition against matrix metalloprotease-2 (MMP-2) using fluorimetric assay


J Med Chem 45: 219-32 (2001)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(homo sapiens (human))
BDBM50348648
PNG
(CHEMBL1801394)
Show SMILES CCOCCN1CCC(CC1)(C(=O)NO)S(=O)(=O)c1ccc(Oc2ccc(OC(F)(F)F)cc2)cc1
Show InChI InChI=1S/C23H27F3N2O7S/c1-2-33-16-15-28-13-11-22(12-14-28,21(29)27-30)36(31,32)20-9-7-18(8-10-20)34-17-3-5-19(6-4-17)35-23(24,25)26/h3-10,30H,2,11-16H2,1H3,(H,27,29)
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n/an/a<0.100n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP2 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(homo sapiens (human))
BDBM50096646
PNG
(2-(4'-Chloro-biphenyl-4-yloxymethyl)-N-hydroxy-4-(...)
Show SMILES ONC(=O)C(CCn1nnc2ccccc2c1=O)COc1ccc(cc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C24H21ClN4O4/c25-19-9-5-16(6-10-19)17-7-11-20(12-8-17)33-15-18(23(30)27-32)13-14-29-24(31)21-3-1-2-4-22(21)26-28-29/h1-12,18,32H,13-15H2,(H,27,30)
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n/an/a 0.100n/an/an/an/an/an/a



Institut de Recherches Servier

Curated by ChEMBL


Assay Description
Inhibition of Matrix metalloproteinase-2


Bioorg Med Chem Lett 11: 295-9 (2001)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(homo sapiens (human))
BDBM50348677
PNG
(CHEMBL1801399)
Show SMILES CC(C)N1CCC(CC1)(C(=O)NO)S(=O)(=O)c1ccc(Oc2ccc(OC(F)(F)F)cc2)cc1
Show InChI InChI=1S/C22H25F3N2O6S/c1-15(2)27-13-11-21(12-14-27,20(28)26-29)34(30,31)19-9-7-17(8-10-19)32-16-3-5-18(6-4-16)33-22(23,24)25/h3-10,15,29H,11-14H2,1-2H3,(H,26,28)
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP2 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(homo sapiens (human))
BDBM50348684
PNG
(CHEMBL1801397)
Show SMILES ONC(=O)C1(CCN(CC#C)CC1)S(=O)(=O)c1ccc(Oc2ccc(OC(F)(F)F)cc2)cc1
Show InChI InChI=1S/C22H21F3N2O6S/c1-2-13-27-14-11-21(12-15-27,20(28)26-29)34(30,31)19-9-7-17(8-10-19)32-16-3-5-18(6-4-16)33-22(23,24)25/h1,3-10,29H,11-15H2,(H,26,28)
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP2 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(homo sapiens (human))
BDBM50348686
PNG
(CHEMBL1801053)
Show SMILES CSc1ccc(Oc2ccc(cc2)S(=O)(=O)C2(CCOCC2)C(=O)NO)cc1
Show InChI InChI=1S/C19H21NO6S2/c1-27-16-6-2-14(3-7-16)26-15-4-8-17(9-5-15)28(23,24)19(18(21)20-22)10-12-25-13-11-19/h2-9,22H,10-13H2,1H3,(H,20,21)
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n/an/a<0.100n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP2 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(homo sapiens (human))
BDBM50348670
PNG
(CHEMBL1801052)
Show SMILES ONC(=O)C1(CCOCC1)S(=O)(=O)c1ccc(Oc2ccc(OC(F)(F)F)cc2)cc1
Show InChI InChI=1S/C19H18F3NO7S/c20-19(21,22)30-15-3-1-13(2-4-15)29-14-5-7-16(8-6-14)31(26,27)18(17(24)23-25)9-11-28-12-10-18/h1-8,25H,9-12H2,(H,23,24)
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP2 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(homo sapiens (human))
BDBM11870
PNG
(4-{[4-(4-Chlorophenoxy)phenyl]sulfonyl}-N-hydroxy ...)
Show SMILES ONC(=O)C1(CCOCC1)S(=O)(=O)c1ccc(Oc2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C18H18ClNO6S/c19-13-1-3-14(4-2-13)26-15-5-7-16(8-6-15)27(23,24)18(17(21)20-22)9-11-25-12-10-18/h1-8,22H,9-12H2,(H,20,21)
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n/an/a<0.100n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP2 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(homo sapiens (human))
BDBM50348687
PNG
(CHEMBL1801049)
Show SMILES CC(C)Oc1ccc(Oc2ccc(cc2)S(=O)(=O)C2(CCOCC2)C(=O)NO)cc1
Show InChI InChI=1S/C21H25NO7S/c1-15(2)28-16-3-5-17(6-4-16)29-18-7-9-19(10-8-18)30(25,26)21(20(23)22-24)11-13-27-14-12-21/h3-10,15,24H,11-14H2,1-2H3,(H,22,23)
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n/an/a<0.100n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP2 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(homo sapiens (human))
BDBM50348647
PNG
(CHEMBL1801396)
Show SMILES CC(=O)N1CCC(CC1)(C(=O)NO)S(=O)(=O)c1ccc(Oc2ccc(OC(F)(F)F)cc2)cc1
Show InChI InChI=1S/C21H21F3N2O7S/c1-14(27)26-12-10-20(11-13-26,19(28)25-29)34(30,31)18-8-6-16(7-9-18)32-15-2-4-17(5-3-15)33-21(22,23)24/h2-9,29H,10-13H2,1H3,(H,25,28)
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP2 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(homo sapiens (human))
BDBM50348658
PNG
(CHEMBL1801424)
Show SMILES ONC(=O)C1(CCN(CC1)C1CC1)S(=O)(=O)c1ccc(Oc2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C22H23F3N2O5S/c23-22(24,25)15-1-5-17(6-2-15)32-18-7-9-19(10-8-18)33(30,31)21(20(28)26-29)11-13-27(14-12-21)16-3-4-16/h1-2,5-10,16,29H,3-4,11-14H2,(H,26,28)
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP2 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(homo sapiens (human))
BDBM50348664
PNG
(CHEMBL1801417)
Show SMILES CC(C)Oc1ccc(Oc2ccc(cc2)S(=O)(=O)C2(CCN(CC2)C2CC2)C(=O)NO)cc1
Show InChI InChI=1S/C24H30N2O6S/c1-17(2)31-19-5-7-20(8-6-19)32-21-9-11-22(12-10-21)33(29,30)24(23(27)25-28)13-15-26(16-14-24)18-3-4-18/h5-12,17-18,28H,3-4,13-16H2,1-2H3,(H,25,27)
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP2 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(homo sapiens (human))
BDBM50348680
PNG
(CHEMBL1801414)
Show SMILES COCCN1CCC(CC1)(C(=O)NO)S(=O)(=O)c1ccc(Oc2ccc(cc2)C(C)C)cc1
Show InChI InChI=1S/C24H32N2O6S/c1-18(2)19-4-6-20(7-5-19)32-21-8-10-22(11-9-21)33(29,30)24(23(27)25-28)12-14-26(15-13-24)16-17-31-3/h4-11,18,28H,12-17H2,1-3H3,(H,25,27)
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP2 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(homo sapiens (human))
BDBM50348666
PNG
(CHEMBL1801413)
Show SMILES CC(C)c1ccc(Oc2ccc(cc2)S(=O)(=O)C2(CCN(CC#C)CC2)C(=O)NO)cc1
Show InChI InChI=1S/C24H28N2O5S/c1-4-15-26-16-13-24(14-17-26,23(27)25-28)32(29,30)22-11-9-21(10-12-22)31-20-7-5-19(6-8-20)18(2)3/h1,5-12,18,28H,13-17H2,2-3H3,(H,25,27)
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP2 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(homo sapiens (human))
BDBM50348681
PNG
(CHEMBL1801412)
Show SMILES CCOc1ccc(Oc2ccc(cc2)S(=O)(=O)C2(CCN(CC2)C2CC2)C(=O)NO)cc1
Show InChI InChI=1S/C23H28N2O6S/c1-2-30-18-5-7-19(8-6-18)31-20-9-11-21(12-10-20)32(28,29)23(22(26)24-27)13-15-25(16-14-23)17-3-4-17/h5-12,17,27H,2-4,13-16H2,1H3,(H,24,26)
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP2 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(homo sapiens (human))
BDBM50348671
PNG
(CHEMBL1229868)
Show SMILES ONC(=O)C1(CCOCC1)S(=O)(=O)c1ccc(Oc2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C19H18F3NO6S/c20-19(21,22)13-1-3-14(4-2-13)29-15-5-7-16(8-6-15)30(26,27)18(17(24)23-25)9-11-28-12-10-18/h1-8,25H,9-12H2,(H,23,24)
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP2 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(homo sapiens (human))
BDBM50348673
PNG
(CHEMBL1801050)
Show SMILES ONC(=O)C1(CCOCC1)S(=O)(=O)c1ccc(Oc2ccc(cc2)-c2ccccc2)cc1
Show InChI InChI=1S/C24H23NO6S/c26-23(25-27)24(14-16-30-17-15-24)32(28,29)22-12-10-21(11-13-22)31-20-8-6-19(7-9-20)18-4-2-1-3-5-18/h1-13,27H,14-17H2,(H,25,26)
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP2 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(homo sapiens (human))
BDBM50348676
PNG
(CHEMBL1801044)
Show SMILES ONC(=O)C1(CCOCC1)S(=O)(=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C18H19NO6S/c20-17(19-21)18(10-12-24-13-11-18)26(22,23)16-8-6-15(7-9-16)25-14-4-2-1-3-5-14/h1-9,21H,10-13H2,(H,19,20)
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP2 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(homo sapiens (human))
BDBM50026872
PNG
(CHEMBL1233506 | SC-74020)
Show SMILES CCCCCc1ccc(cc1)C(=O)Nc1ccc(cc1)S(=O)(=O)N(CCN1CCOCC1)[C@H](C(C)C)C(=O)NO
Show InChI InChI=1/C29H42N4O6S/c1-4-5-6-7-23-8-10-24(11-9-23)28(34)30-25-12-14-26(15-13-25)40(37,38)33(27(22(2)3)29(35)31-36)17-16-32-18-20-39-21-19-32/h8-15,22,27,36H,4-7,16-21H2,1-3H3,(H,30,34)(H,31,35)/t27-/s2
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Colosseum Combinatorial Chemistry Centre for Technology (C4T SCarl)

Curated by ChEMBL


Assay Description
Inhibition of full length MMP2 using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured after 3...


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(homo sapiens (human))
BDBM50389096
PNG
(CHEMBL2064549)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1cn(CCOCCOCCOCCF)nn1)[C@H](C(C)C)C(=O)NO
Show InChI InChI=1S/C23H36FN5O8S/c1-18(2)22(23(30)26-31)29(38(32,33)21-6-4-20(34-3)5-7-21)17-19-16-28(27-25-19)9-11-36-13-15-37-14-12-35-10-8-24/h4-7,16,18,22,31H,8-15,17H2,1-3H3,(H,26,30)/t22-/m1/s1
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University Hospital M£nster

Curated by ChEMBL


Assay Description
Inhibition of MMP2 using (7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl)Ala-Arg-NH2 as substrate incuba...


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(homo sapiens (human))
BDBM50348646
PNG
(CHEMBL1801398)
Show SMILES CN1CCC(CC1)(C(=O)NO)S(=O)(=O)c1ccc(Oc2ccc(OC(F)(F)F)cc2)cc1
Show InChI InChI=1S/C20H21F3N2O6S/c1-25-12-10-19(11-13-25,18(26)24-27)32(28,29)17-8-6-15(7-9-17)30-14-2-4-16(5-3-14)31-20(21,22)23/h2-9,27H,10-13H2,1H3,(H,24,26)
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP2 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(homo sapiens (human))
BDBM50343077
PNG
(CHEMBL1771212 | N-hydroxy-1-(2-methoxyethyl)-4-(4-...)
Show SMILES COCCN1CCC(CC1)(C(=O)NO)S(=O)(=O)c1ccc(Oc2ccc(OC(F)(F)F)cc2)cc1
Show InChI InChI=1S/C22H25F3N2O7S/c1-32-15-14-27-12-10-21(11-13-27,20(28)26-29)35(30,31)19-8-6-17(7-9-19)33-16-2-4-18(5-3-16)34-22(23,24)25/h2-9,29H,10-15H2,1H3,(H,26,28)
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP-2


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(homo sapiens (human))
BDBM50343077
PNG
(CHEMBL1771212 | N-hydroxy-1-(2-methoxyethyl)-4-(4-...)
Show SMILES COCCN1CCC(CC1)(C(=O)NO)S(=O)(=O)c1ccc(Oc2ccc(OC(F)(F)F)cc2)cc1
Show InChI InChI=1S/C22H25F3N2O7S/c1-32-15-14-27-12-10-21(11-13-27,20(28)26-29)35(30,31)19-8-6-17(7-9-19)33-16-2-4-18(5-3-16)34-22(23,24)25/h2-9,29H,10-15H2,1H3,(H,26,28)
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP2 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(homo sapiens (human))
BDBM50348652
PNG
(CHEMBL1801429)
Show SMILES ONC(=O)C1(CCNCC1)S(=O)(=O)c1ccc(Oc2ccc(OC(F)(F)F)cc2)cc1
Show InChI InChI=1S/C19H19F3N2O6S/c20-19(21,22)30-15-3-1-13(2-4-15)29-14-5-7-16(8-6-14)31(27,28)18(17(25)24-26)9-11-23-12-10-18/h1-8,23,26H,9-12H2,(H,24,25)
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP2 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(homo sapiens (human))
BDBM50348651
PNG
(CHEMBL1801430)
Show SMILES ONC(=O)C1(CCN(CC1)C1CC1)S(=O)(=O)c1ccc(Oc2ccc(OC(F)(F)F)cc2)cc1
Show InChI InChI=1S/C22H23F3N2O6S/c23-22(24,25)33-18-5-3-16(4-6-18)32-17-7-9-19(10-8-17)34(30,31)21(20(28)26-29)11-13-27(14-12-21)15-1-2-15/h3-10,15,29H,1-2,11-14H2,(H,26,28)
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP2 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(homo sapiens (human))
BDBM50348685
PNG
(CHEMBL1801395)
Show SMILES OCCN1CCC(CC1)(C(=O)NO)S(=O)(=O)c1ccc(Oc2ccc(OC(F)(F)F)cc2)cc1
Show InChI InChI=1S/C21H23F3N2O7S/c22-21(23,24)33-17-3-1-15(2-4-17)32-16-5-7-18(8-6-16)34(30,31)20(19(28)25-29)9-11-26(12-10-20)13-14-27/h1-8,27,29H,9-14H2,(H,25,28)
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP2 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(homo sapiens (human))
BDBM50348649
PNG
(CHEMBL1801393)
Show SMILES ONC(=O)C1(CCN(Cc2cccnc2)CC1)S(=O)(=O)c1ccc(Oc2ccc(OC(F)(F)F)cc2)cc1
Show InChI InChI=1S/C25H24F3N3O6S/c26-25(27,28)37-21-5-3-19(4-6-21)36-20-7-9-22(10-8-20)38(34,35)24(23(32)30-33)11-14-31(15-12-24)17-18-2-1-13-29-16-18/h1-10,13,16,33H,11-12,14-15,17H2,(H,30,32)
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n/an/a<0.100n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP2 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(homo sapiens (human))
BDBM50071267
PNG
((7S,8R,11S)-9-Oxo-8-[2-(4-propyl-phenyl)-ethyl]-2-...)
Show SMILES CCCc1ccc(CC[C@@H]2[C@H](CCCCOc3ccc(C[C@H](NC2=O)C(=O)NC)cc3)C(=O)NO)cc1
Show InChI InChI=1S/C29H39N3O5/c1-3-6-20-8-10-21(11-9-20)14-17-25-24(28(34)32-36)7-4-5-18-37-23-15-12-22(13-16-23)19-26(29(35)30-2)31-27(25)33/h8-13,15-16,24-26,36H,3-7,14,17-19H2,1-2H3,(H,30,35)(H,31,33)(H,32,34)/t24-,25+,26-/m0/s1
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n/an/a 0.100n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of fibroblast gelatinase A (MMP-2)


Bioorg Med Chem Lett 8: 2087-92 (1999)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(homo sapiens (human))
BDBM50062351
PNG
((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)
Show SMILES CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)CC(=O)NO
Show InChI InChI=1S/C20H28N4O4/c1-12(2)8-13(10-18(25)24-28)19(26)23-17(20(27)21-3)9-14-11-22-16-7-5-4-6-15(14)16/h4-7,11-13,17,22,28H,8-10H2,1-3H3,(H,21,27)(H,23,26)(H,24,25)/t13-,17+/m1/s1
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n/an/a 0.104n/an/an/an/an/an/a



UMR/CNRS 6013

Curated by ChEMBL


Assay Description
Inhibition of human matrix metalloproteinase-2


Bioorg Med Chem Lett 13: 2843-6 (2003)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(homo sapiens (human))
BDBM50389100
PNG
(CHEMBL2064547)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1cn(CCF)nn1)[C@H](C(C)C)C(=O)NO
Show InChI InChI=1S/C17H24FN5O5S/c1-12(2)16(17(24)20-25)23(11-13-10-22(9-8-18)21-19-13)29(26,27)15-6-4-14(28-3)5-7-15/h4-7,10,12,16,25H,8-9,11H2,1-3H3,(H,20,24)/t16-/m1/s1
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n/an/a 0.130n/an/an/an/an/an/a



University Hospital M£nster

Curated by ChEMBL


Assay Description
Inhibition of MMP2 using (7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl)Ala-Arg-NH2 as substrate incuba...


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(homo sapiens (human))
BDBM50119282
PNG
(CHEMBL3617404)
Show SMILES COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N(OC(C)C)[C@H](CCNC(C)=O)C(=O)NO
Show InChI InChI=1/C22H29N3O7S/c1-15(2)32-25(21(22(27)24-28)13-14-23-16(3)26)33(29,30)20-11-7-18(8-12-20)17-5-9-19(31-4)10-6-17/h5-12,15,21,28H,13-14H2,1-4H3,(H,23,26)(H,24,27)/t21-/s2
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n/an/a 0.130n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Inhibition of recombinant human activated-MMP2 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as fluorogenic substrate incubated for 4 hrs follow...


J Med Chem 58: 7224-40 (2015)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(homo sapiens (human))
BDBM50348650
PNG
(CHEMBL1801431)
Show SMILES ONC(=O)C1(CCN(Cc2ccccn2)CC1)S(=O)(=O)c1ccc(Oc2ccc(OC(F)(F)F)cc2)cc1
Show InChI InChI=1S/C25H24F3N3O6S/c26-25(27,28)37-21-6-4-19(5-7-21)36-20-8-10-22(11-9-20)38(34,35)24(23(32)30-33)12-15-31(16-13-24)17-18-3-1-2-14-29-18/h1-11,14,33H,12-13,15-17H2,(H,30,32)
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n/an/a 0.200n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP2 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(homo sapiens (human))
BDBM50105450
PNG
(2-(4-Phenoxy-benzenesulfonylmethyl)-1-prop-2-ynyl-...)
Show SMILES ONC(=O)C1(CS(=O)(=O)c2ccc(Oc3ccccc3)cc2)CCCN1CC#C
Show InChI InChI=1S/C21H22N2O5S/c1-2-14-23-15-6-13-21(23,20(24)22-25)16-29(26,27)19-11-9-18(10-12-19)28-17-7-4-3-5-8-17/h1,3-5,7-12,25H,6,13-16H2,(H,22,24)
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n/an/a 0.200n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human Matrix metalloprotease-2


Bioorg Med Chem Lett 11: 2723-5 (2001)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(homo sapiens (human))
BDBM50348654
PNG
(CHEMBL1801427)
Show SMILES CCN1CCC(CC1)(C(=O)NO)S(=O)(=O)c1ccc(Oc2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C21H23F3N2O5S/c1-2-26-13-11-20(12-14-26,19(27)25-28)32(29,30)18-9-7-17(8-10-18)31-16-5-3-15(4-6-16)21(22,23)24/h3-10,28H,2,11-14H2,1H3,(H,25,27)
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n/an/a 0.200n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP2 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(homo sapiens (human))
BDBM50348659
PNG
(CHEMBL1801423)
Show SMILES ONC(=O)C1(CCN(CC1)C1CC1)S(=O)(=O)c1ccc(Oc2ccc3OCCOc3c2)cc1
Show InChI InChI=1S/C23H26N2O7S/c26-22(24-27)23(9-11-25(12-10-23)16-1-2-16)33(28,29)19-6-3-17(4-7-19)32-18-5-8-20-21(15-18)31-14-13-30-20/h3-8,15-16,27H,1-2,9-14H2,(H,24,26)
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n/an/a 0.200n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP2 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(homo sapiens (human))
BDBM50348661
PNG
(CHEMBL1801420)
Show SMILES ONC(=O)C1(CCN(CC#C)CC1)S(=O)(=O)c1ccc(Oc2ccc3OCOc3c2)cc1
Show InChI InChI=1S/C22H22N2O7S/c1-2-11-24-12-9-22(10-13-24,21(25)23-26)32(27,28)18-6-3-16(4-7-18)31-17-5-8-19-20(14-17)30-15-29-19/h1,3-8,14,26H,9-13,15H2,(H,23,25)
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n/an/a 0.200n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP2 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(homo sapiens (human))
BDBM50348667
PNG
(CHEMBL1801057)
Show SMILES COc1ccc(Oc2ccc(cc2)S(=O)(=O)C2(CCN(Cc3ccccn3)CC2)C(=O)NO)cc1
Show InChI InChI=1S/C25H27N3O6S/c1-33-20-5-7-21(8-6-20)34-22-9-11-23(12-10-22)35(31,32)25(24(29)27-30)13-16-28(17-14-25)18-19-4-2-3-15-26-19/h2-12,15,30H,13-14,16-18H2,1H3,(H,27,29)
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n/an/a 0.200n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP2 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assay


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(homo sapiens (human))
BDBM50348683
PNG
(CHEMBL1801048)
Show SMILES ONC(=O)C1(CCOCC1)S(=O)(=O)c1ccc(Oc2ccc(O)cc2)cc1
Show InChI InChI=1S/C18H19NO7S/c20-13-1-3-14(4-2-13)26-15-5-7-16(8-6-15)27(23,24)18(17(21)19-22)9-11-25-12-10-18/h1-8,20,22H,9-12H2,(H,19,21)
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human MMP2 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assay


Citation and Details
More data for this
Ligand-Target Pair
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