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Compile Data Set for Download or QSAR

Found 123 hits Enz. Inhib. hit(s) with Target = 'Matrix protein 2'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Matrix protein 2


(Influenza A virus)
BDBM50494442
PNG
(CHEMBL3088292)
Show SMILES Cl.NC(=N)N1CC23CC45CC2(C1)CC4(C3)CCCC5
Show InChI InChI=1S/C15H23N3.ClH/c16-11(17)18-9-14-5-12-3-1-2-4-13(12,7-14)8-15(14,6-12)10-18;/h1-10H2,(H3,16,17);1H
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n/an/a 290n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of Influenza A virus Udorn/72 M2 ion channel V27A mutant expressed in Xenopus oocyte plasma membranes after 2 mins by two-electrode voltag...


J Med Chem 56: 9265-74 (2013)

More data for this
Ligand-Target Pair
Matrix protein 2


(Influenza A virus)
BDBM50080000
PNG
(CHEMBL3415952)
Show SMILES NC(=N)N1C[C@H]2[C@@H](C1)[C@H]1[C@@H]3C4CC1[C@H]2[C@H]34
Show InChI InChI=1/C12H17N3/c13-12(14)15-2-6-7(3-15)9-4-1-5-10(8(4)6)11(5)9/h4-11H,1-3H2,(H3,13,14)/t4?,5?,6-,7+,8+,9-,10+,11-
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n/an/a 800n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of wild type Influenza A virus (A/udorn/1972(H3N2)) M2 channel expressed in Xenopus oocyte plasma membranes after 2 mins by two-electrode ...


Eur J Med Chem 96: 318-29 (2015)


Article DOI: 10.1016/j.ejmech.2015.04.030
BindingDB Entry DOI: 10.7270/Q2B27X1P
More data for this
Ligand-Target Pair
Matrix protein 2


(Influenza A virus (A/Udorn/307/1972(H3N2)))
BDBM50500845
PNG
(3-Azoniaspiro[5.5]Undecane Chloride | CHEMBL204131...)
Show SMILES Cl.C1CCC2(CC1)CCNCC2
Show InChI InChI=1S/C10H19N.ClH/c1-2-4-10(5-3-1)6-8-11-9-7-10;/h11H,1-9H2;1H
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PubMed
n/an/a 900n/an/an/an/an/an/a



The University of Arizona

Curated by ChEMBL


Assay Description
Inhibition of Influenza A virus wild type M2 proton channel infected in Xenopus laevis oocytes after 2 mins by TEVC assay


J Med Chem 59: 1207-16 (2016)

More data for this
Ligand-Target Pair
Matrix protein 2


(Influenza A virus (A/Udorn/307/1972(H3N2)))
BDBM50020755
PNG
(CHEMBL3286977)
Show SMILES C1CC2C1C1CCC2C2CNCC12
Show InChI InChI=1/C12H19N.ClH/c1-2-8-7(1)9-3-4-10(8)12-6-13-5-11(9)12;/h7-13H,1-6H2;1H
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n/an/a 1.24E+3n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of wild type Influenza A virus (A/udorn/72(H3N2)) M2 channel expressed in Xenopus oocyte plasma membrane incubated for 2 mins measured ove...


J Med Chem 57: 5738-47 (2014)


Article DOI: 10.1021/jm5005804
BindingDB Entry DOI: 10.7270/Q23N24Z2
More data for this
Ligand-Target Pair
Matrix protein 2


(Influenza A virus (A/Udorn/307/1972(H3N2)))
BDBM50020751
PNG
(CHEMBL3286971)
Show SMILES NC(=N)N1CC2C(C1)C1C=CC2C2CC12
Show InChI InChI=1/C12H17N3.ClH/c13-12(14)15-4-10-6-1-2-7(11(10)5-15)9-3-8(6)9;/h1-2,6-11H,3-5H2,(H3,13,14);1H
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n/an/a 1.50E+3n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of wild type Influenza A virus (A/udorn/72(H3N2)) M2 channel expressed in Xenopus oocyte plasma membrane incubated for 2 mins measured ove...


J Med Chem 57: 5738-47 (2014)


Article DOI: 10.1021/jm5005804
BindingDB Entry DOI: 10.7270/Q23N24Z2
More data for this
Ligand-Target Pair
Matrix protein 2


(Influenza A virus (A/Udorn/307/1972(H3N2)))
BDBM50020753
PNG
(CHEMBL3286973)
Show SMILES NC(=N)N1CC2C(C1)C1CCC2C2CC12
Show InChI InChI=1/C12H19N3.ClH/c13-12(14)15-4-10-6-1-2-7(11(10)5-15)9-3-8(6)9;/h6-11H,1-5H2,(H3,13,14);1H
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n/an/a 1.64E+3n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of wild type Influenza A virus (A/udorn/72(H3N2)) M2 channel expressed in Xenopus oocyte plasma membrane incubated for 2 mins measured ove...


J Med Chem 57: 5738-47 (2014)


Article DOI: 10.1021/jm5005804
BindingDB Entry DOI: 10.7270/Q23N24Z2
More data for this
Ligand-Target Pair
Matrix protein 2


(Influenza A virus (A/Udorn/307/1972(H3N2)))
BDBM50266584
PNG
(CHEMBL4074389)
Show SMILES NC(=N)N1CCC(CC1)C12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C16H27N3/c17-15(18)19-3-1-14(2-4-19)16-8-11-5-12(9-16)7-13(6-11)10-16/h11-14H,1-10H2,(H3,17,18)
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n/an/a 1.90E+3n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of Influenza A virus A/Udorn/72 wild-type M2 proton channel expressed in Xenopus laevis oocytes at pH 5.5 after 2 mins at -20 mV holding p...


J Med Chem 60: 3727-3738 (2017)

More data for this
Ligand-Target Pair
Matrix protein 2


(Influenza A virus (A/Udorn/307/1972(H3N2)))
BDBM50020854
PNG
(CHEMBL3286978)
Show SMILES Cl.NC(=N)N1CC2C(C1)C1CCC2C2CCC12
Show InChI InChI=1/C13H21N3.ClH/c14-13(15)16-5-11-9-3-4-10(12(11)6-16)8-2-1-7(8)9;/h7-12H,1-6H2,(H3,14,15);1H
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n/an/a 2.08E+3n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of wild type Influenza A virus (A/udorn/72(H3N2)) M2 channel expressed in Xenopus oocyte plasma membrane incubated for 2 mins measured ove...


J Med Chem 57: 5738-47 (2014)


Article DOI: 10.1021/jm5005804
BindingDB Entry DOI: 10.7270/Q23N24Z2
More data for this
Ligand-Target Pair
Matrix protein 2


(Influenza A virus)
BDBM50079994
PNG
(CHEMBL3305169)
Show SMILES NC(=N)N1CC2C(C1)C1CCC2C2CCC12
Show InChI InChI=1/C13H21N3/c14-13(15)16-5-11-9-3-4-10(12(11)6-16)8-2-1-7(8)9/h7-12H,1-6H2,(H3,14,15)
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n/an/a 2.10E+3n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of wild type Influenza A virus (A/udorn/1972(H3N2)) M2 channel expressed in Xenopus oocyte plasma membranes after 2 mins by two-electrode ...


Eur J Med Chem 96: 318-29 (2015)


Article DOI: 10.1016/j.ejmech.2015.04.030
BindingDB Entry DOI: 10.7270/Q2B27X1P
More data for this
Ligand-Target Pair
Matrix protein 2


(Influenza A virus)
BDBM50079996
PNG
(CHEMBL3415948)
Show SMILES C1NCC2C1C1C3C4C5C3C2C2C5CCC4C12
Show InChI InChI=1/C16H21N/c1-2-6-10-9-5(1)11-12(6)16-14(10)8-4-17-3-7(8)13(9)15(11)16/h5-17H,1-4H2/t5-,6+,7+,8-,9-,10+,11-,12-,13-,14+,15+,16+/s2
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n/an/a 2.10E+3n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of wild type Influenza A virus (A/udorn/1972(H3N2)) M2 channel expressed in Xenopus oocyte plasma membranes after 2 mins by two-electrode ...


Eur J Med Chem 96: 318-29 (2015)


Article DOI: 10.1016/j.ejmech.2015.04.030
BindingDB Entry DOI: 10.7270/Q2B27X1P
More data for this
Ligand-Target Pair
Matrix protein 2


(Influenza A virus)
BDBM50343543
PNG
(CHEMBL499125 | N-(Hexahydro-2,5-methano-pentalen-3...)
Show SMILES NC(N)=NCC12CC3CC1CC(C2)C3
Show InChI InChI=1/C11H19N3/c12-10(13)14-6-11-4-7-1-8(5-11)3-9(11)2-7/h7-9H,1-6H2,(H4,12,13,14)
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n/an/a 2.40E+3n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of Influenza A virus (A/Udorn/72) wild type matrix protein 2 expressed in xenopus oocytes after 2 mins by two-electrode voltage clamp assa...


J Med Chem 54: 2646-57 (2011)


Article DOI: 10.1021/jm101334y
BindingDB Entry DOI: 10.7270/Q2H41RR0
More data for this
Ligand-Target Pair
Matrix protein 2


(Influenza A virus)
BDBM50079995
PNG
(CHEMBL3415947)
Show SMILES C1NCC2C1C1C3C4C5C3C2C2C5C=CC4C12
Show InChI InChI=1/C16H19N/c1-2-6-10-9-5(1)11-12(6)16-14(10)8-4-17-3-7(8)13(9)15(11)16/h1-2,5-17H,3-4H2/t5-,6+,7+,8-,9-,10+,11-,12-,13-,14+,15+,16+/s2
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n/an/a 2.60E+3n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of wild type Influenza A virus (A/udorn/1972(H3N2)) M2 channel expressed in Xenopus oocyte plasma membranes after 2 mins by two-electrode ...


Eur J Med Chem 96: 318-29 (2015)


Article DOI: 10.1016/j.ejmech.2015.04.030
BindingDB Entry DOI: 10.7270/Q2B27X1P
More data for this
Ligand-Target Pair
Matrix protein 2


(Influenza A virus (A/Udorn/307/1972(H3N2)))
BDBM50020750
PNG
(CHEMBL3286970)
Show SMILES C1C2C1C1C=CC2C2CNCC12
Show InChI InChI=1/C11H15N.ClH/c1-2-7-9-3-8(9)6(1)10-4-12-5-11(7)10;/h1-2,6-12H,3-5H2;1H
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n/an/a 2.92E+3n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of wild type Influenza A virus (A/udorn/72(H3N2)) M2 channel expressed in Xenopus oocyte plasma membrane incubated for 2 mins measured ove...


J Med Chem 57: 5738-47 (2014)


Article DOI: 10.1021/jm5005804
BindingDB Entry DOI: 10.7270/Q23N24Z2
More data for this
Ligand-Target Pair
Matrix protein 2


(Influenza A virus)
BDBM50079999
PNG
(CHEMBL3415951)
Show SMILES C1NC[C@@H]2[C@H]1[C@@H]1[C@H]3C4CC1[C@@H]2[C@@H]34
Show InChI InChI=1/C11H15N/c1-4-8-6-2-12-3-7(6)9(4)11-5(1)10(8)11/h4-12H,1-3H2/t4?,5?,6-,7+,8+,9-,10+,11-
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n/an/a 3.30E+3n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of wild type Influenza A virus (A/udorn/1972(H3N2)) M2 channel expressed in Xenopus oocyte plasma membranes after 2 mins by two-electrode ...


Eur J Med Chem 96: 318-29 (2015)


Article DOI: 10.1016/j.ejmech.2015.04.030
BindingDB Entry DOI: 10.7270/Q2B27X1P
More data for this
Ligand-Target Pair
Matrix protein 2


(Influenza A virus (A/Udorn/307/1972(H3N2)))
BDBM50020752
PNG
(CHEMBL3286972)
Show SMILES C1C2C1C1CCC2C2CNCC12
Show InChI InChI=1/C11H17N.ClH/c1-2-7-9-3-8(9)6(1)10-4-12-5-11(7)10;/h6-12H,1-5H2;1H
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PubMed
n/an/a 3.38E+3n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of wild type Influenza A virus (A/udorn/72(H3N2)) M2 channel expressed in Xenopus oocyte plasma membrane incubated for 2 mins measured ove...


J Med Chem 57: 5738-47 (2014)


Article DOI: 10.1021/jm5005804
BindingDB Entry DOI: 10.7270/Q23N24Z2
More data for this
Ligand-Target Pair
Matrix protein 2


(Influenza A virus)
BDBM50079997
PNG
(CHEMBL3415949)
Show SMILES NC(=N)N1CC2C(C1)C1C3C4C5C3C2C2C5CCC4C12
Show InChI InChI=1/C17H23N3/c18-17(19)20-3-7-8(4-20)14-10-6-2-1-5-9(10)13(7)15-11(5)12(6)16(14)15/h5-16H,1-4H2,(H3,18,19)/t5-,6+,7+,8-,9-,10+,11-,12-,13-,14+,15+,16+/s2
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n/an/a 3.70E+3n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of wild type Influenza A virus (A/udorn/1972(H3N2)) M2 channel expressed in Xenopus oocyte plasma membranes after 2 mins by two-electrode ...


Eur J Med Chem 96: 318-29 (2015)


Article DOI: 10.1016/j.ejmech.2015.04.030
BindingDB Entry DOI: 10.7270/Q2B27X1P
More data for this
Ligand-Target Pair
Matrix protein 2


(Influenza A virus (A/Udorn/307/1972(H3N2)))
BDBM50465108
PNG
(CHEMBL4277543)
Show SMILES CC(C)(N)C12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C13H23N/c1-12(2,14)13-6-9-3-10(7-13)5-11(4-9)8-13/h9-11H,3-8,14H2,1-2H3
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n/an/a 4.00E+3n/an/an/an/an/an/a



National and Kapodistrian University of Athens

Curated by ChEMBL


Assay Description
Inhibition of Influenza A virus A/Udorn/72 wild-type M2 proton channel expressed in Xenopus laevis oocytes assessed as blockade of inward currents at...


ACS Med Chem Lett 9: 198-203 (2018)

More data for this
Ligand-Target Pair
Matrix protein 2


(Influenza A virus (A/Udorn/307/1972(H3N2)))
BDBM50266582
PNG
(CHEMBL4104405)
Show SMILES C1CC(CCN1)C12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C15H25N/c1-3-16-4-2-14(1)15-8-11-5-12(9-15)7-13(6-11)10-15/h11-14,16H,1-10H2
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n/an/a 4.10E+3n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of Influenza A virus A/Udorn/72 wild-type M2 proton channel expressed in Xenopus laevis oocytes at pH 5.5 after 2 mins at -20 mV holding p...


J Med Chem 60: 3727-3738 (2017)

More data for this
Ligand-Target Pair
Matrix protein 2


(Influenza A virus (A/Udorn/307/1972(H3N2)))
BDBM50266585
PNG
(CHEMBL4096027)
Show SMILES NC(=N)N1CCC(CC2C3CC4CC(C3)CC2C4)CC1
Show InChI InChI=1S/C17H29N3/c18-17(19)20-3-1-11(2-4-20)10-16-14-6-12-5-13(8-14)9-15(16)7-12/h11-16H,1-10H2,(H3,18,19)
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n/an/a 4.20E+3n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of Influenza A virus A/Udorn/72 wild-type M2 proton channel expressed in Xenopus laevis oocytes at pH 5.5 after 2 mins at -20 mV holding p...


J Med Chem 60: 3727-3738 (2017)

More data for this
Ligand-Target Pair
Matrix protein 2


(Influenza A virus (A/Udorn/307/1972(H3N2)))
BDBM50033369
PNG
(AMANTADINE | CHEMBL660 | SYMADINE | SYMMETREL)
Show SMILES NC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C10H17N/c11-10-4-7-1-8(5-10)3-9(2-7)6-10/h7-9H,1-6,11H2
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n/an/a 4.70E+3n/an/an/an/an/an/a



National and Kapodistrian University of Athens

Curated by ChEMBL


Assay Description
Inhibition of Influenza A virus A/Udorn/72 wild-type M2 proton channel expressed in Xenopus laevis oocytes assessed as blockade of inward currents at...


ACS Med Chem Lett 9: 198-203 (2018)

More data for this
Ligand-Target Pair
Matrix protein 2


(Influenza A virus (A/Udorn/307/1972(H3N2)))
BDBM50020844
PNG
(CHEMBL3286403)
Show SMILES Cl.NC(=N)N1CC2C(C1)C1C=CC2C2C=CC12
Show InChI InChI=1/C13H17N3.ClH/c14-13(15)16-5-11-9-3-4-10(12(11)6-16)8-2-1-7(8)9;/h1-4,7-12H,5-6H2,(H3,14,15);1H
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n/an/a 4.93E+3n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of wild type Influenza A virus (A/udorn/72(H3N2)) M2 channel expressed in Xenopus oocyte plasma membrane incubated for 2 mins measured ove...


J Med Chem 57: 5738-47 (2014)


Article DOI: 10.1021/jm5005804
BindingDB Entry DOI: 10.7270/Q23N24Z2
More data for this
Ligand-Target Pair
Matrix protein 2


(Influenza A virus (A/Udorn/307/1972(H3N2)))
BDBM50020754
PNG
(CHEMBL3286976)
Show SMILES C1NCC2C1C1C=CC2C2C=CC12
Show InChI InChI=1/C12H15N.ClH/c1-2-8-7(1)9-3-4-10(8)12-6-13-5-11(9)12;/h1-4,7-13H,5-6H2;1H
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n/an/a 5.54E+3n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of wild type Influenza A virus (A/udorn/72(H3N2)) M2 channel expressed in Xenopus oocyte plasma membrane incubated for 2 mins measured ove...


J Med Chem 57: 5738-47 (2014)


Article DOI: 10.1021/jm5005804
BindingDB Entry DOI: 10.7270/Q23N24Z2
More data for this
Ligand-Target Pair
Matrix protein 2


(Influenza A virus)
BDBM50079998
PNG
(CHEMBL3415950)
Show SMILES NC(=N)N1CC2C(C1)C1C3C4C5C3C2C2C5C=CC4C12
Show InChI InChI=1/C17H21N3/c18-17(19)20-3-7-8(4-20)14-10-6-2-1-5-9(10)13(7)15-11(5)12(6)16(14)15/h1-2,5-16H,3-4H2,(H3,18,19)/t5-,6+,7+,8-,9-,10+,11-,12-,13-,14+,15+,16+/s2
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n/an/a 6.50E+3n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of wild type Influenza A virus (A/udorn/1972(H3N2)) M2 channel expressed in Xenopus oocyte plasma membranes after 2 mins by two-electrode ...


Eur J Med Chem 96: 318-29 (2015)


Article DOI: 10.1016/j.ejmech.2015.04.030
BindingDB Entry DOI: 10.7270/Q2B27X1P
More data for this
Ligand-Target Pair
Matrix protein 2


(Influenza A virus (A/Udorn/307/1972(H3N2)))
BDBM50266586
PNG
(CHEMBL4061974)
Show SMILES NC(=N)N1CCC(CC1)C=C1C2CC3CC(C2)CC1C3
Show InChI InChI=1S/C17H27N3/c18-17(19)20-3-1-11(2-4-20)10-16-14-6-12-5-13(8-14)9-15(16)7-12/h10-15H,1-9H2,(H3,18,19)/b16-10-
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n/an/a 6.80E+3n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of Influenza A virus A/Udorn/72 wild-type M2 proton channel expressed in Xenopus laevis oocytes at pH 5.5 after 2 mins at -20 mV holding p...


J Med Chem 60: 3727-3738 (2017)

More data for this
Ligand-Target Pair
Matrix protein 2


(Influenza A virus)
BDBM50343541
PNG
(C-(Hexahydro-2,5-methano-pentalen-3a-yl)-methylami...)
Show SMILES NCC12CC3CC1CC(C2)C3
Show InChI InChI=1/C10H17N/c11-6-10-4-7-1-8(5-10)3-9(10)2-7/h7-9H,1-6,11H2
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n/an/a 7.10E+3n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of Influenza A virus (A/Udorn/72) wild type matrix protein 2 expressed in xenopus oocytes after 2 mins by two-electrode voltage clamp assa...


J Med Chem 54: 2646-57 (2011)


Article DOI: 10.1021/jm101334y
BindingDB Entry DOI: 10.7270/Q2H41RR0
More data for this
Ligand-Target Pair
Matrix protein 2


(Influenza A virus)
BDBM50343546
PNG
(C-(2,5-Dimethyl-hexahydro-2,5-cyclo-pentalen-3a-yl...)
Show SMILES CC12CC3CC1(C)CC3(CN)C2
Show InChI InChI=1/C11H19N/c1-9-3-8-4-10(9,2)6-11(8,5-9)7-12/h8H,3-7,12H2,1-2H3
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n/an/a 7.20E+3n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of Influenza A virus (A/Udorn/72) wild type matrix protein 2 expressed in xenopus oocytes after 2 mins by two-electrode voltage clamp assa...


J Med Chem 54: 2646-57 (2011)


Article DOI: 10.1021/jm101334y
BindingDB Entry DOI: 10.7270/Q2H41RR0
More data for this
Ligand-Target Pair
Matrix protein 2


(Influenza A virus (A/Udorn/307/1972(H3N2)))
BDBM50465108
PNG
(CHEMBL4277543)
Show SMILES CC(C)(N)C12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C13H23N/c1-12(2,14)13-6-9-3-10(7-13)5-11(4-9)8-13/h9-11H,3-8,14H2,1-2H3
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n/an/a 9.30E+3n/an/an/an/an/an/a



National and Kapodistrian University of Athens

Curated by ChEMBL


Assay Description
Inhibition of Influenza A virus A/Udorn/72 wild-type M2 proton channel expressed in Xenopus laevis oocytes assessed as blockade of inward currents at...


ACS Med Chem Lett 9: 198-203 (2018)

More data for this
Ligand-Target Pair
Matrix protein 2


(Influenza A virus (A/Udorn/307/1972(H3N2)))
BDBM50020857
PNG
(CHEMBL3286980)
Show SMILES Cl.CC12CC34CN(CC33CC1(C)C(C)(C3)C2(C)C4)C(N)=N
Show InChI InChI=1S/C17H27N3.ClH/c1-12-5-16-6-13(12,2)15(4)8-17(16,7-14(12,15)3)10-20(9-16)11(18)19;/h5-10H2,1-4H3,(H3,18,19);1H
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n/an/a 1.07E+4n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of wild type Influenza A virus (A/udorn/72(H3N2)) M2 channel expressed in Xenopus oocyte plasma membrane incubated for 2 mins measured ove...


J Med Chem 57: 5738-47 (2014)


Article DOI: 10.1021/jm5005804
BindingDB Entry DOI: 10.7270/Q23N24Z2
More data for this
Ligand-Target Pair
Matrix protein 2


(Influenza A virus (A/Udorn/307/1972(H3N2)))
BDBM50216627
PNG
((alpha-methyl-1-adamantyl)methylamine | 1-Adamanta...)
Show SMILES CC(N)C12CC3CC(CC(C3)C1)C2
Show InChI InChI=1/C12H21N/c1-8(13)12-5-9-2-10(6-12)4-11(3-9)7-12/h8-11H,2-7,13H2,1H3
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n/an/a 1.08E+4n/an/an/an/an/an/a



National and Kapodistrian University of Athens

Curated by ChEMBL


Assay Description
Inhibition of Influenza A virus A/Udorn/72 wild-type M2 proton channel expressed in Xenopus laevis oocytes assessed as blockade of inward currents at...


ACS Med Chem Lett 9: 198-203 (2018)

More data for this
Ligand-Target Pair
Matrix protein 2


(Influenza A virus)
BDBM50494443
PNG
(CHEMBL3088163)
Show SMILES Cl.CC12CC34CN(CC3(C1)CC2(C)C4)C(N)=N
Show InChI InChI=1S/C13H21N3.ClH/c1-10-3-12-5-11(10,2)6-13(12,4-10)8-16(7-12)9(14)15;/h3-8H2,1-2H3,(H3,14,15);1H
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n/an/a 1.14E+4n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of Influenza A virus Udorn/72 M2 ion channel V27A mutant expressed in Xenopus oocyte plasma membranes after 2 mins by two-electrode voltag...


J Med Chem 56: 9265-74 (2013)

More data for this
Ligand-Target Pair
Matrix protein 2


(Influenza A virus (A/Udorn/307/1972(H3N2)))
BDBM50033369
PNG
(AMANTADINE | CHEMBL660 | SYMADINE | SYMMETREL)
Show SMILES NC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C10H17N/c11-10-4-7-1-8(5-10)3-9(2-7)6-10/h7-9H,1-6,11H2
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n/an/a 1.25E+4n/an/an/an/an/an/a



National and Kapodistrian University of Athens

Curated by ChEMBL


Assay Description
Inhibition of Influenza A virus A/Udorn/72 wild-type M2 proton channel expressed in Xenopus laevis oocytes assessed as blockade of inward currents at...


ACS Med Chem Lett 9: 198-203 (2018)

More data for this
Ligand-Target Pair
Matrix protein 2


(Influenza A virus)
BDBM50343544
PNG
(CHEMBL1774313 | rac-1-(Hexahydro-2,5-methano-penta...)
Show SMILES CC(N)C12CC3CC1CC(C2)C3
Show InChI InChI=1/C11H19N/c1-7(12)11-5-8-2-9(6-11)4-10(11)3-8/h7-10H,2-6,12H2,1H3
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n/an/a 1.27E+4n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of Influenza A virus (A/Udorn/72) wild type matrix protein 2 expressed in xenopus oocytes after 2 mins by two-electrode voltage clamp assa...


J Med Chem 54: 2646-57 (2011)


Article DOI: 10.1021/jm101334y
BindingDB Entry DOI: 10.7270/Q2H41RR0
More data for this
Ligand-Target Pair
Matrix protein 2


(Influenza A virus (A/Udorn/307/1972(H3N2)))
BDBM50465104
PNG
(CHEMBL4284791)
Show SMILES CCC(N)(CC)C12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C15H27N/c1-3-15(16,4-2)14-8-11-5-12(9-14)7-13(6-11)10-14/h11-13H,3-10,16H2,1-2H3
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n/an/a 1.32E+4n/an/an/an/an/an/a



National and Kapodistrian University of Athens

Curated by ChEMBL


Assay Description
Inhibition of Influenza A virus A/Udorn/72 wild-type M2 proton channel expressed in Xenopus laevis oocytes assessed as blockade of inward currents at...


ACS Med Chem Lett 9: 198-203 (2018)

More data for this
Ligand-Target Pair
Matrix protein 2


(Influenza A virus)
BDBM50494444
PNG
(CHEMBL3088168)
Show SMILES Cl.CCC12CC34CN(CC3(C1)CC2(CC)C4)C(N)=N
Show InChI InChI=1S/C15H25N3.ClH/c1-3-12-5-14-7-13(12,4-2)8-15(14,6-12)10-18(9-14)11(16)17;/h3-10H2,1-2H3,(H3,16,17);1H
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n/an/a 1.38E+4n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of Influenza A virus Udorn/72 M2 ion channel V27A mutant expressed in Xenopus oocyte plasma membranes after 2 mins by two-electrode voltag...


J Med Chem 56: 9265-74 (2013)

More data for this
Ligand-Target Pair
Matrix protein 2


(Influenza A virus (A/Udorn/307/1972(H3N2)))
BDBM50033369
PNG
(AMANTADINE | CHEMBL660 | SYMADINE | SYMMETREL)
Show SMILES NC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C10H17N/c11-10-4-7-1-8(5-10)3-9(2-7)6-10/h7-9H,1-6,11H2
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n/an/a 1.60E+4n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of wild type Influenza A virus (A/udorn/72(H3N2)) M2 channel expressed in Xenopus oocyte plasma membrane incubated for 2 mins measured ove...


J Med Chem 57: 5738-47 (2014)


Article DOI: 10.1021/jm5005804
BindingDB Entry DOI: 10.7270/Q23N24Z2
More data for this
Ligand-Target Pair
Matrix protein 2


(Influenza A virus)
BDBM50033369
PNG
(AMANTADINE | CHEMBL660 | SYMADINE | SYMMETREL)
Show SMILES NC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C10H17N/c11-10-4-7-1-8(5-10)3-9(2-7)6-10/h7-9H,1-6,11H2
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n/an/a 1.60E+4n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of Influenza A virus (A/Udorn/72) wild type matrix protein 2 expressed in xenopus oocytes after 2 mins by two-electrode voltage clamp assa...


J Med Chem 54: 2646-57 (2011)


Article DOI: 10.1021/jm101334y
BindingDB Entry DOI: 10.7270/Q2H41RR0
More data for this
Ligand-Target Pair
Matrix protein 2


(Influenza A virus (A/Udorn/307/1972(H3N2)))
BDBM50033369
PNG
(AMANTADINE | CHEMBL660 | SYMADINE | SYMMETREL)
Show SMILES NC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C10H17N/c11-10-4-7-1-8(5-10)3-9(2-7)6-10/h7-9H,1-6,11H2
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n/an/a 1.61E+4n/an/an/an/an/an/a



The University of Arizona

Curated by ChEMBL


Assay Description
Inhibition of Influenza A virus wild type M2 proton channel infected in Xenopus laevis oocytes after 2 mins by TEVC assay


J Med Chem 59: 1207-16 (2016)

More data for this
Ligand-Target Pair
Matrix protein 2


(Influenza A virus)
BDBM50343545
PNG
(2,5-Dimethyl-hexahydro-2,5-cyclo-pentalen-3a-ylami...)
Show SMILES CC12CC3CC1(C)CC3(N)C2
Show InChI InChI=1/C10H17N/c1-8-3-7-4-9(8,2)6-10(7,11)5-8/h7H,3-6,11H2,1-2H3
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n/an/a 1.70E+4n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of Influenza A virus (A/Udorn/72) wild type matrix protein 2 expressed in xenopus oocytes after 2 mins by two-electrode voltage clamp assa...


J Med Chem 54: 2646-57 (2011)


Article DOI: 10.1021/jm101334y
BindingDB Entry DOI: 10.7270/Q2H41RR0
More data for this
Ligand-Target Pair
Matrix protein 2


(Influenza A virus)
BDBM50343542
PNG
((Hexahydro-2,5-methano-pentalen-3a-ylmethyl)-methy...)
Show SMILES CNCC12CC3CC1CC(C2)C3
Show InChI InChI=1/C11H19N/c1-12-7-11-5-8-2-9(6-11)4-10(11)3-8/h8-10,12H,2-7H2,1H3
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n/an/a 1.71E+4n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of Influenza A virus (A/Udorn/72) wild type matrix protein 2 expressed in xenopus oocytes after 2 mins by two-electrode voltage clamp assa...


J Med Chem 54: 2646-57 (2011)


Article DOI: 10.1021/jm101334y
BindingDB Entry DOI: 10.7270/Q2H41RR0
More data for this
Ligand-Target Pair
Matrix protein 2


(Influenza A virus)
BDBM50079996
PNG
(CHEMBL3415948)
Show SMILES C1NCC2C1C1C3C4C5C3C2C2C5CCC4C12
Show InChI InChI=1/C16H21N/c1-2-6-10-9-5(1)11-12(6)16-14(10)8-4-17-3-7(8)13(9)15(11)16/h5-17H,1-4H2/t5-,6+,7+,8-,9-,10+,11-,12-,13-,14+,15+,16+/s2
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n/an/a 1.72E+4n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of Influenza A virus (A/udorn/1972(H3N2)) M2 V27A mutant channel expressed in Xenopus oocyte plasma membranes after 2 mins by two-electrod...


Eur J Med Chem 96: 318-29 (2015)


Article DOI: 10.1016/j.ejmech.2015.04.030
BindingDB Entry DOI: 10.7270/Q2B27X1P
More data for this
Ligand-Target Pair
Matrix protein 2


(Influenza A virus (A/Udorn/307/1972(H3N2)))
BDBM50020855
PNG
(CHEMBL3286979)
Show SMILES Cl.CC12CC34CNCC33CC1(C)C(C)(C3)C2(C)C4
Show InChI InChI=1S/C16H25N.ClH/c1-11-5-15-6-12(11,2)14(4)8-16(15,10-17-9-15)7-13(11,14)3;/h17H,5-10H2,1-4H3;1H
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n/an/a 1.80E+4n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of wild type Influenza A virus (A/udorn/72(H3N2)) M2 channel expressed in Xenopus oocyte plasma membrane incubated for 2 mins measured ove...


J Med Chem 57: 5738-47 (2014)


Article DOI: 10.1021/jm5005804
BindingDB Entry DOI: 10.7270/Q23N24Z2
More data for this
Ligand-Target Pair
Matrix protein 2


(Influenza A virus (A/Udorn/307/1972(H3N2)))
BDBM50500846
PNG
(CHEMBL3770480)
Show InChI InChI=1S/C15H25N.ClH/c16-14-1-3-15(4-2-14)12-6-10-5-11(8-12)9-13(15)7-10;/h10-14H,1-9,16H2;1H
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n/an/a 1.87E+4n/an/an/an/an/an/a



The University of Arizona

Curated by ChEMBL


Assay Description
Inhibition of Influenza A virus wild type M2 proton channel infected in Xenopus laevis oocytes after 2 mins by TEVC assay


J Med Chem 59: 1207-16 (2016)

More data for this
Ligand-Target Pair
Matrix protein 2


(Influenza A virus)
BDBM50494441
PNG
(CHEMBL3088169)
Show SMILES OC(C(O)C(O)=O)C(O)=O.C1NCC23CC45CC12CC4(C3)CCCC5
Show InChI InChI=1S/C14H21N.C4H6O6/c1-2-4-12-7-13-5-11(12,3-1)6-14(13,8-12)10-15-9-13;5-1(3(7)8)2(6)4(9)10/h15H,1-10H2;1-2,5-6H,(H,7,8)(H,9,10)
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n/an/a 2.05E+4n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of Influenza A virus Udorn/72 M2 ion channel V27A mutant expressed in Xenopus oocyte plasma membranes after 2 mins by two-electrode voltag...


J Med Chem 56: 9265-74 (2013)

More data for this
Ligand-Target Pair
Matrix protein 2


(Influenza A virus)
BDBM50079994
PNG
(CHEMBL3305169)
Show SMILES NC(=N)N1CC2C(C1)C1CCC2C2CCC12
Show InChI InChI=1/C13H21N3/c14-13(15)16-5-11-9-3-4-10(12(11)6-16)8-2-1-7(8)9/h7-12H,1-6H2,(H3,14,15)
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n/an/a 2.26E+4n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of Influenza A virus (A/udorn/1972(H3N2)) M2 V27A mutant channel expressed in Xenopus oocyte plasma membranes after 2 mins by two-electrod...


Eur J Med Chem 96: 318-29 (2015)


Article DOI: 10.1016/j.ejmech.2015.04.030
BindingDB Entry DOI: 10.7270/Q2B27X1P
More data for this
Ligand-Target Pair
Matrix protein 2


(Influenza A virus)
BDBM50343548
PNG
(CHEMBL468166 | Methyl-(2-oxa-tricyclo[3.3.1.1(3,7)...)
Show SMILES CNC12CC3CC(CC(C3)O1)C2
Show InChI InChI=1/C10H17NO/c1-11-10-5-7-2-8(6-10)4-9(3-7)12-10/h7-9,11H,2-6H2,1H3
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n/an/a 2.29E+4n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of Influenza A virus (A/Udorn/72) wild type matrix protein 2 expressed in xenopus oocytes after 2 mins by two-electrode voltage clamp assa...


J Med Chem 54: 2646-57 (2011)


Article DOI: 10.1021/jm101334y
BindingDB Entry DOI: 10.7270/Q2H41RR0
More data for this
Ligand-Target Pair
Matrix protein 2


(Influenza A virus)
BDBM50343550
PNG
(3-Azaoctacyclo[8.7.0.0(1,5).0(5,13).0(6,11).0(7,9)...)
Show SMILES C1C2C1C1C3C2C24CNCC12C1C2CC2C4C31
Show InChI InChI=1/C16H19N/c1-5-6(1)12-9-10-13-7-2-8(7)14(10)16(12)4-17-3-15(13,16)11(5)9/h5-14,17H,1-4H2
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n/an/a 2.40E+4n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of Influenza A virus (A/Udorn/72) wild type matrix protein 2 expressed in xenopus oocytes after 2 mins by two-electrode voltage clamp assa...


J Med Chem 54: 2646-57 (2011)


Article DOI: 10.1021/jm101334y
BindingDB Entry DOI: 10.7270/Q2H41RR0
More data for this
Ligand-Target Pair
Matrix protein 2


(Influenza A virus (A/Udorn/307/1972(H3N2)))
BDBM50465104
PNG
(CHEMBL4284791)
Show SMILES CCC(N)(CC)C12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C15H27N/c1-3-15(16,4-2)14-8-11-5-12(9-14)7-13(6-11)10-14/h11-13H,3-10,16H2,1-2H3
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n/an/a 2.43E+4n/an/an/an/an/an/a



National and Kapodistrian University of Athens

Curated by ChEMBL


Assay Description
Inhibition of Influenza A virus A/Udorn/72 wild-type M2 proton channel expressed in Xenopus laevis oocytes assessed as blockade of inward currents at...


ACS Med Chem Lett 9: 198-203 (2018)

More data for this
Ligand-Target Pair
Matrix protein 2


(Influenza A virus)
BDBM50343547
PNG
((2-Oxaadamant-1-yl)amine | 2-Oxa-tricyclo[3.3.1.1(...)
Show SMILES NC12CC3CC(CC(C3)O1)C2
Show InChI InChI=1/C9H15NO/c10-9-4-6-1-7(5-9)3-8(2-6)11-9/h6-8H,1-5,10H2
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n/an/a 2.92E+4n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of Influenza A virus (A/Udorn/72) wild type matrix protein 2 expressed in xenopus oocytes after 2 mins by two-electrode voltage clamp assa...


J Med Chem 54: 2646-57 (2011)


Article DOI: 10.1021/jm101334y
BindingDB Entry DOI: 10.7270/Q2H41RR0
More data for this
Ligand-Target Pair
Matrix protein 2


(Influenza A virus (A/Udorn/307/1972(H3N2)))
BDBM50462117
PNG
(CHEMBL2311603)
Show SMILES Cl.NC1CC[Si]2(CCCCC2)CC1
Show InChI InChI=1S/C10H21NSi.ClH/c11-10-4-8-12(9-5-10)6-2-1-3-7-12;/h10H,1-9,11H2;1H
UniProtKB/SwissProt

GoogleScholar
UniChem
PubMed
n/an/a 3.13E+4n/an/an/an/an/an/a



CSIR-National Chemical Laboratory

Curated by ChEMBL


Assay Description
Inhibition of Influenza A virus M2 V27A mutant expressed in Xenopus laevis oocytes by two-electrode voltage clamp method


J Med Chem 61: 3779-3798 (2018)

More data for this
Ligand-Target Pair
Matrix protein 2


(Influenza A virus)
BDBM50079997
PNG
(CHEMBL3415949)
Show SMILES NC(=N)N1CC2C(C1)C1C3C4C5C3C2C2C5CCC4C12
Show InChI InChI=1/C17H23N3/c18-17(19)20-3-7-8(4-20)14-10-6-2-1-5-9(10)13(7)15-11(5)12(6)16(14)15/h5-16H,1-4H2,(H3,18,19)/t5-,6+,7+,8-,9-,10+,11-,12-,13-,14+,15+,16+/s2
UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.22E+4n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of Influenza A virus (A/udorn/1972(H3N2)) M2 V27A mutant channel expressed in Xenopus oocyte plasma membranes after 2 mins by two-electrod...


Eur J Med Chem 96: 318-29 (2015)


Article DOI: 10.1016/j.ejmech.2015.04.030
BindingDB Entry DOI: 10.7270/Q2B27X1P
More data for this
Ligand-Target Pair
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