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Found 7 hits Enz. Inhib. hit(s) with Target = 'Megakaryocyte protein-tyrosine phosphatase (PTP-MEG2)'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Megakaryocyte protein-tyrosine phosphatase (PTP-MEG2)


(Homo sapiens (Human))
BDBM124261
PNG
(2-((5-Bromo-2-oxybenzylidene)amino)benzoato-diaqua...)
Show SMILES [OH2+][V]12([OH2+])(=O)OC(=O)c3ccccc3[N]1=Cc1cc(ccc1O2)[N+]([O-])=O
Show InChI InChI=1S/C14H10N2O5.2H2O.O.V/c17-13-6-5-10(16(20)21)7-9(13)8-15-12-4-2-1-3-11(12)14(18)19;;;;/h1-8,17H,(H,18,19);2*1H2;;/q;;;;+4/p-2/b15-8+;;;;
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Article
PubMed
n/an/a 600n/an/an/an/an/an/a



Shanxi University



Assay Description
The assays were performed in 20 mM MOPS buffer, pH 7.2, containing 50 mM NaCl and 2 mM GSH. Compounds were dissolved in DMSO and diluted to various c...


Citation and Details
More data for this
Ligand-Target Pair
Megakaryocyte protein-tyrosine phosphatase (PTP-MEG2)


(Homo sapiens (Human))
BDBM124260
PNG
(2-((5-Bromo-2-oxybenzylidene)amino)benzoato-diaqua...)
Show SMILES [OH2+][V]12([OH2+])(=O)OC(=O)c3ccccc3[N]1=Cc1cc(Br)ccc1O2
Show InChI InChI=1S/C14H10BrNO3.2H2O.O.V/c15-10-5-6-13(17)9(7-10)8-16-12-4-2-1-3-11(12)14(18)19;;;;/h1-8,17H,(H,18,19);2*1H2;;/q;;;;+4/p-2/b16-8+;;;;
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Article
PubMed
n/an/a 970n/an/an/an/an/an/a



Shanxi University



Assay Description
The assays were performed in 20 mM MOPS buffer, pH 7.2, containing 50 mM NaCl and 2 mM GSH. Compounds were dissolved in DMSO and diluted to various c...


Citation and Details
More data for this
Ligand-Target Pair
Megakaryocyte protein-tyrosine phosphatase (PTP-MEG2)


(Homo sapiens (Human))
BDBM124263
PNG
(Bis(4-bromo-2-((phenylimino)methyl)phenolate)-oxov...)
Show SMILES Brc1ccc2O[V]3(=O)(Oc4ccc(Br)cc4C=[N]3c3ccccc3)[N](=Cc2c1)c1ccccc1
Show InChI InChI=1S/2C13H10BrNO.O.V/c2*14-11-6-7-13(16)10(8-11)9-15-12-4-2-1-3-5-12;;/h2*1-9,16H;;/q;;;+2/p-2/b2*15-9+;;
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n/an/a 2.90E+3n/an/an/an/an/an/a



Shanxi University



Assay Description
The assays were performed in 20 mM MOPS buffer, pH 7.2, containing 50 mM NaCl and 2 mM GSH. Compounds were dissolved in DMSO and diluted to various c...


Citation and Details
More data for this
Ligand-Target Pair
Megakaryocyte protein-tyrosine phosphatase (PTP-MEG2)


(Homo sapiens (Human))
BDBM124264
PNG
(Bis(4-nitro-2-((phenylimino)methyl)phenolate)-oxov...)
Show SMILES [O-][N+](=O)c1ccc2O[V]3(=O)(Oc4ccc(cc4C=[N]3c3ccccc3)[N+]([O-])=O)[N](=Cc2c1)c1ccccc1
Show InChI InChI=1S/2C13H10N2O3.O.V/c2*16-13-7-6-12(15(17)18)8-10(13)9-14-11-4-2-1-3-5-11;;/h2*1-9,16H;;/q;;;+2/p-2/b2*14-9+;;
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n/an/a 3.20E+3n/an/an/an/an/an/a



Shanxi University



Assay Description
The assays were performed in 20 mM MOPS buffer, pH 7.2, containing 50 mM NaCl and 2 mM GSH. Compounds were dissolved in DMSO and diluted to various c...


Citation and Details
More data for this
Ligand-Target Pair
Megakaryocyte protein-tyrosine phosphatase (PTP-MEG2)


(Homo sapiens (Human))
BDBM124262
PNG
(Bis(4-chloro-2-((phenylimino)methyl)phenolate)-oxo...)
Show SMILES Clc1ccc2O[V]3(=O)(Oc4ccc(Cl)cc4C=[N]3c3ccccc3)[N](=Cc2c1)c1ccccc1
Show InChI InChI=1S/2C13H10ClNO.O.V/c2*14-11-6-7-13(16)10(8-11)9-15-12-4-2-1-3-5-12;;/h2*1-9,16H;;/q;;;+2/p-2/b2*15-9+;;
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KEGG

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Article
PubMed
n/an/a 3.60E+3n/an/an/an/an/an/a



Shanxi University



Assay Description
The assays were performed in 20 mM MOPS buffer, pH 7.2, containing 50 mM NaCl and 2 mM GSH. Compounds were dissolved in DMSO and diluted to various c...


Citation and Details
More data for this
Ligand-Target Pair
Megakaryocyte protein-tyrosine phosphatase (PTP-MEG2)


(Homo sapiens (Human))
BDBM231167
PNG
(US9340574, 7)
Show SMILES COc1cc(CC(=O)NCC(NC(=O)C(CCCNC(=O)c2cccc(I)c2)NC(=O)C(Cc2ccc(cc2)C(F)(F)P(O)(O)=O)NC(=O)c2ccc(C)c(Br)c2)C(N)=O)ccc1O
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US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



Indiana University Research and Technology Corporation

US Patent


Assay Description
PTP activity was assayed using p-nitrophenyl phosphate (pNPP) as a substrate in 3,3-dimethylglutarate buffer (50 mM 3,3-dimethylglutarate, pH 7.0, 1 ...


US Patent US9340574 (2016)

More data for this
Ligand-Target Pair
Megakaryocyte protein-tyrosine phosphatase (PTP-MEG2)


(Homo sapiens (Human))
BDBM50107739
PNG
(CHEMBL140954 | [(4-{4-[4-(Difluoro-phosphono-methy...)
Show SMILES OP(O)(=O)C(F)(F)c1ccc(COc2ccc(OCc3ccc(cc3)C(F)(F)P(O)(O)=O)cc2)cc1
Show InChI InChI=1S/C22H20F4O8P2/c23-21(24,35(27,28)29)17-5-1-15(2-6-17)13-33-19-9-11-20(12-10-19)34-14-16-3-7-18(8-4-16)22(25,26)36(30,31)32/h1-12H,13-14H2,(H2,27,28,29)(H2,30,31,32)
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PubMed
n/an/a 1.46E+5n/an/an/an/an/an/a



University of Waterloo

Curated by ChEMBL


Assay Description
Inhibitory activity against Protein tyrosine phosphatase PTPmeg-1.


J Med Chem 44: 4584-94 (2001)

More data for this
Ligand-Target Pair