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Compile Data Set for Download or QSAR

Found 4659 hits Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50215552
PNG
(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Show SMILES FCc1nc(cs1)C#Cc1cc(F)cc(c1)C#N
Show InChI InChI=1S/C13H6F2N2S/c14-6-13-17-12(8-18-13)2-1-9-3-10(7-16)5-11(15)4-9/h3-5,8H,6H2
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n/an/a 0.0360n/an/an/an/an/an/a



National Institute of Mental Health

Curated by ChEMBL


Assay Description
Displacement of [3H]MPEP from mGluR5 in rat brain membrane


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50215556
PNG
(3-(2-(2-(fluoromethyl)thiazol-4-yl)ethynyl)benzoni...)
Show SMILES FCc1nc(cs1)C#Cc1cccc(c1)C#N
Show InChI InChI=1S/C13H7FN2S/c14-7-13-16-12(9-17-13)5-4-10-2-1-3-11(6-10)8-15/h1-3,6,9H,7H2
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n/an/a 0.0600n/an/an/an/an/an/a



National Institute of Mental Health

Curated by ChEMBL


Assay Description
Displacement of [3H]MPEP from mGluR5 in rat brain membrane


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50084137
PNG
(2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...)
Show SMILES Cc1cccc(n1)C#Cc1ccccc1
Show InChI InChI=1S/C14H11N/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13/h2-9H,1H3
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n/an/a 0.200n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50215553
PNG
(5-(2-(2-fluoromethyl)thiazole-4-yl)ethynyl)pyridin...)
Show SMILES FCc1nc(cs1)C#Cc1cncc(c1)C#N
Show InChI InChI=1S/C12H6FN3S/c13-4-12-16-11(8-17-12)2-1-9-3-10(5-14)7-15-6-9/h3,6-8H,4H2
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n/an/a 0.230n/an/an/an/an/an/a



National Institute of Mental Health

Curated by ChEMBL


Assay Description
Displacement of [3H]MPEP from mGluR5 in rat brain membrane


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50345567
PNG
(3-(2-(5-methylpyridin-2-yl)ethynyl)-5-fluorobenzon...)
Show SMILES Cc1ccc(nc1)C#Cc1cc(F)cc(c1)C#N
Show InChI InChI=1S/C15H9FN2/c1-11-2-4-15(18-10-11)5-3-12-6-13(9-17)8-14(16)7-12/h2,4,6-8,10H,1H3
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n/an/a 0.320n/an/an/an/an/an/a



Institute for Neurodegenerative Disorders

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50345570
PNG
(3-(2-(pyridin-2-yl)ethynyl)-5-bromonitrobenzene | ...)
Show SMILES [O-][N+](=O)c1cc(Br)cc(c1)C#Cc1ccccn1
Show InChI InChI=1S/C13H7BrN2O2/c14-11-7-10(8-13(9-11)16(17)18)4-5-12-3-1-2-6-15-12/h1-3,6-9H
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n/an/a 0.390n/an/an/an/an/an/a



Institute for Neurodegenerative Disorders

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50160632
PNG
(3-(6-Methyl-pyridin-2-ylethynyl)-benzonitrile | 3-...)
Show SMILES Cc1cccc(n1)C#Cc1cccc(c1)C#N
Show InChI InChI=1S/C15H10N2/c1-12-4-2-7-15(17-12)9-8-13-5-3-6-14(10-13)11-16/h2-7,10H,1H3
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n/an/a 0.420n/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR5 expressed in HEK293A cells assessed as glutamate-induced calcium flux preincubated for 140 sec before glutamate cha...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50215555
PNG
(2-(fluoromethyl)-4-(2-(3-fluorophenyl)ethynylthiaz...)
Show SMILES FCc1nc(cs1)C#Cc1cccc(F)c1
Show InChI InChI=1S/C12H7F2NS/c13-7-12-15-11(8-16-12)5-4-9-2-1-3-10(14)6-9/h1-3,6,8H,7H2
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n/an/a 0.480n/an/an/an/an/an/a



National Institute of Mental Health

Curated by ChEMBL


Assay Description
Displacement of [3H]MPEP from mGluR5 in rat brain membrane


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50215554
PNG
(2-(fluoromethyl)4-(2-(3-methoxyphenyl)ethynyl)thia...)
Show SMILES COc1cccc(c1)C#Cc1csc(CF)n1
Show InChI InChI=1S/C13H10FNOS/c1-16-12-4-2-3-10(7-12)5-6-11-9-17-13(8-14)15-11/h2-4,7,9H,8H2,1H3
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n/an/a 0.520n/an/an/an/an/an/a



National Institute of Mental Health

Curated by ChEMBL


Assay Description
Displacement of [3H]MPEP from mGluR5 in rat brain membrane


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50345555
PNG
(3-(2-(2-methylthiazol-4-yl)ethynyl)-5-nitrofluorob...)
Show SMILES Cc1nc(cs1)C#Cc1cc(F)cc(c1)[N+]([O-])=O
Show InChI InChI=1S/C12H7FN2O2S/c1-8-14-11(7-18-8)3-2-9-4-10(13)6-12(5-9)15(16)17/h4-7H,1H3
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n/an/a 0.610n/an/an/an/an/an/a



Institute for Neurodegenerative Disorders

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50345560
PNG
(3-(2-(6-methylpyridin-2-yl)ethynyl)-5-nitrobromobe...)
Show SMILES Cc1cccc(n1)C#Cc1cc(Br)cc(c1)[N+]([O-])=O
Show InChI InChI=1S/C14H9BrN2O2/c1-10-3-2-4-13(16-10)6-5-11-7-12(15)9-14(8-11)17(18)19/h2-4,7-9H,1H3
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n/an/a 0.630n/an/an/an/an/an/a



Institute for Neurodegenerative Disorders

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50345573
PNG
(3-(2-(pyridin-2-yl)ethynyl)-5-iodobenzonitrile | C...)
Show SMILES Ic1cc(cc(c1)C#Cc1ccccn1)C#N
Show InChI InChI=1S/C14H7IN2/c15-13-8-11(7-12(9-13)10-16)4-5-14-3-1-2-6-17-14/h1-3,6-9H
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n/an/a 0.660n/an/an/an/an/an/a



Institute for Neurodegenerative Disorders

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50345572
PNG
(3-(2-(pyridin-2-yl)ethynyl)-5-fluorobenzonitrile |...)
Show SMILES Fc1cc(cc(c1)C#Cc1ccccn1)C#N
Show InChI InChI=1S/C14H7FN2/c15-13-8-11(7-12(9-13)10-16)4-5-14-3-1-2-6-17-14/h1-3,6-9H
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n/an/a 0.660n/an/an/an/an/an/a



Institute for Neurodegenerative Disorders

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50345574
PNG
(3-(2-(pyridin-2-yl)ethynyl)-5-nitrofluorobenzene |...)
Show SMILES [O-][N+](=O)c1cc(F)cc(c1)C#Cc1ccccn1
Show InChI InChI=1S/C13H7FN2O2/c14-11-7-10(8-13(9-11)16(17)18)4-5-12-3-1-2-6-15-12/h1-3,6-9H
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n/an/a 0.660n/an/an/an/an/an/a



Institute for Neurodegenerative Disorders

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50345563
PNG
(3-(2-(6-methylpyridin-2-yl)ethynyl)-5-iodobenzonit...)
Show SMILES Cc1cccc(n1)C#Cc1cc(I)cc(c1)C#N
Show InChI InChI=1S/C15H9IN2/c1-11-3-2-4-15(18-11)6-5-12-7-13(10-17)9-14(16)8-12/h2-4,7-9H,1H3
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n/an/a 0.710n/an/an/an/an/an/a



Institute for Neurodegenerative Disorders

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50215552
PNG
(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Show SMILES FCc1nc(cs1)C#Cc1cc(F)cc(c1)C#N
Show InChI InChI=1S/C13H6F2N2S/c14-6-13-17-12(8-18-13)2-1-9-3-10(7-16)5-11(15)4-9/h3-5,8H,6H2
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n/an/a 0.714n/an/an/an/an/an/a



National Institute of Mental Health

Curated by ChEMBL


Assay Description
Activity at human recombinant mGluR5 in CHO cells assessed as inhibition of quisqualate-stimulated phosphoinositide hydrolysis


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50220087
PNG
(2-(3,5-dichlorophenyl)-7-methylpyrido[2,3-d]pyrimi...)
Show SMILES Cc1ccc2cnc(nc2n1)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C14H9Cl2N3/c1-8-2-3-9-7-17-13(19-14(9)18-8)10-4-11(15)6-12(16)5-10/h2-7H,1H3
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n/an/a 0.720n/an/an/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Antagonistic activity at rat mGluR5 expressed in CHO cells assessed as inhibition of quisqualate stimulated calcium mobilization by FLIPR technology


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50345551
PNG
(3-(2-(2-methylthiazol-4-yl)ethynyl)-5-nitrobromobe...)
Show SMILES Cc1nc(cs1)C#Cc1cc(Br)cc(c1)[N+]([O-])=O
Show InChI InChI=1S/C12H7BrN2O2S/c1-8-14-11(7-18-8)3-2-9-4-10(13)6-12(5-9)15(16)17/h4-7H,1H3
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n/an/a 0.730n/an/an/an/an/an/a



Institute for Neurodegenerative Disorders

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50216746
PNG
(3-fluoro-5-(2-methylquinolin-7-yl)benzonitrile | C...)
Show SMILES Cc1ccc2ccc(cc2n1)-c1cc(F)cc(c1)C#N
Show InChI InChI=1S/C17H11FN2/c1-11-2-3-13-4-5-14(9-17(13)20-11)15-6-12(10-19)7-16(18)8-15/h2-9H,1H3
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n/an/a 0.800n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50258612
PNG
(3-Fluoro-5-cyano-1-(2-methylthiazol-4-ylethynyl)be...)
Show SMILES Cc1nc(cs1)C#Cc1cc(F)cc(c1)C#N
Show InChI InChI=1S/C13H7FN2S/c1-9-16-13(8-17-9)3-2-10-4-11(7-15)6-12(14)5-10/h4-6,8H,1H3
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n/an/a 0.810n/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR5 expressed in HEK293A cells assessed as glutamate-induced calcium flux preincubated for 140 sec before glutamate cha...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50379862
PNG
(CHEMBL2011870)
Show SMILES COc1ccc(cc1)-c1nsc(NC(=O)[C@@H]2C[C@H]2C)c1C
Show InChI InChI=1S/C16H18N2O2S/c1-9-8-13(9)15(19)17-16-10(2)14(18-21-16)11-4-6-12(20-3)7-5-11/h4-7,9,13H,8H2,1-3H3,(H,17,19)/t9-,13-/m1/s1
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n/an/a 0.900n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50177100
PNG
(3-Cycloheptyl-9-dimethylamino-3H-pyrido[3',2':4,5]...)
Show SMILES CN(C)c1ccnc2sc3c(ncn(C4CCCCCC4)c3=O)c12
Show InChI InChI=1S/C18H22N4OS/c1-21(2)13-9-10-19-17-14(13)15-16(24-17)18(23)22(11-20-15)12-7-5-3-4-6-8-12/h9-12H,3-8H2,1-2H3
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n/an/a 1n/an/an/an/an/an/a



Biocampus

Curated by ChEMBL


Assay Description
Inhibition of rat mGluR1


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50177080
PNG
(3-azepan-1-yl-9-dimethylamino-3H-pyrido[3',2':4,5]...)
Show SMILES CN(C)c1ccnc2sc3c(ncn(N4CCCCCC4)c3=O)c12
Show InChI InChI=1S/C17H21N5OS/c1-20(2)12-7-8-18-16-13(12)14-15(24-16)17(23)22(11-19-14)21-9-5-3-4-6-10-21/h7-8,11H,3-6,9-10H2,1-2H3
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n/an/a 1n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1 expressed in 1321N1 cells


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50345568
PNG
(3-(2-(5-methylpyridin-2-yl)ethynyl)-5-bromobenzoni...)
Show SMILES Cc1ccc(nc1)C#Cc1cc(Br)cc(c1)C#N
Show InChI InChI=1S/C15H9BrN2/c1-11-2-4-15(18-10-11)5-3-12-6-13(9-17)8-14(16)7-12/h2,4,6-8,10H,1H3
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n/an/a 1.02n/an/an/an/an/an/a



Institute for Neurodegenerative Disorders

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50345571
PNG
(3-(2-(pyridin-2-yl)ethynyl)-5-chlorobenzonitrile |...)
Show SMILES Clc1cc(cc(c1)C#Cc1ccccn1)C#N
Show InChI InChI=1S/C14H7ClN2/c15-13-8-11(7-12(9-13)10-16)4-5-14-3-1-2-6-17-14/h1-3,6-9H
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n/an/a 1.03n/an/an/an/an/an/a



Institute for Neurodegenerative Disorders

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50345554
PNG
(3-(2-(2-methylthiazol-4-yl)ethynyl)-5-iodobenzonit...)
Show SMILES Cc1nc(cs1)C#Cc1cc(I)cc(c1)C#N
Show InChI InChI=1S/C13H7IN2S/c1-9-16-13(8-17-9)3-2-10-4-11(7-15)6-12(14)5-10/h4-6,8H,1H3
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n/an/a 1.05n/an/an/an/an/an/a



Institute for Neurodegenerative Disorders

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50345553
PNG
(3-(2-(2-methylthiazol-4-yl)ethynyl)-5-bromobenzoni...)
Show SMILES Cc1nc(cs1)C#Cc1cc(Br)cc(c1)C#N
Show InChI InChI=1S/C13H7BrN2S/c1-9-16-13(8-17-9)3-2-10-4-11(7-15)6-12(14)5-10/h4-6,8H,1H3
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n/an/a 1.06n/an/an/an/an/an/a



Institute for Neurodegenerative Disorders

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50345557
PNG
(3-(2-(2-methylthiazol-4-yl)ethynyl)-5-bromofluorob...)
Show SMILES Cc1nc(cs1)C#Cc1cc(F)cc(Br)c1
Show InChI InChI=1S/C12H7BrFNS/c1-8-15-12(7-16-8)3-2-9-4-10(13)6-11(14)5-9/h4-7H,1H3
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n/an/a 1.11n/an/an/an/an/an/a



Institute for Neurodegenerative Disorders

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50220096
PNG
(3-methoxy-5-(7-methylpyrido[2,3-d]pyrimidin-2-yl)b...)
Show SMILES COc1cc(cc(c1)-c1ncc2ccc(C)nc2n1)C#N
Show InChI InChI=1S/C16H12N4O/c1-10-3-4-12-9-18-15(20-16(12)19-10)13-5-11(8-17)6-14(7-13)21-2/h3-7,9H,1-2H3
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n/an/a 1.20n/an/an/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Antagonistic activity at rat mGluR5 expressed in CHO cells assessed as inhibition of quisqualate stimulated calcium mobilization by FLIPR technology


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50149801
PNG
(2-Phenyl-5-(2-methylthiazol-4ylethynyl)pyridine | ...)
Show SMILES Cc1nc(cs1)C#Cc1ccc(nc1)-c1ccccc1
Show InChI InChI=1S/C17H12N2S/c1-13-19-16(12-20-13)9-7-14-8-10-17(18-11-14)15-5-3-2-4-6-15/h2-6,8,10-12H,1H3
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n/an/a 1.20n/an/an/an/an/an/a



National Institute on Drug Abuse-Intramural Research Program

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR5 expressed in HEK293A cells assessed as glutamate-induced calcium flux preincubated for 140 sec before glutamate cha...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50345561
PNG
(3-(2-(6-methylpyridin-2-yl)ethynyl)-5-chlorobenzon...)
Show SMILES Cc1cccc(n1)C#Cc1cc(Cl)cc(c1)C#N
Show InChI InChI=1S/C15H9ClN2/c1-11-3-2-4-15(18-11)6-5-12-7-13(10-17)9-14(16)8-12/h2-4,7-9H,1H3
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n/an/a 1.22n/an/an/an/an/an/a



Institute for Neurodegenerative Disorders

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50345562
PNG
(3-(2-(6-methylpyridin-2-yl)ethynyl)-5-fluorobenzon...)
Show SMILES Cc1cccc(n1)C#Cc1cc(F)cc(c1)C#N
Show InChI InChI=1S/C15H9FN2/c1-11-3-2-4-15(18-11)6-5-12-7-13(10-17)9-14(16)8-12/h2-4,7-9H,1H3
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n/an/a 1.22n/an/an/an/an/an/a



Institute for Neurodegenerative Disorders

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50345566
PNG
(3-(2-(5-methylpyridin-2-yl)ethynyl)-5-chlorobenzon...)
Show SMILES Cc1ccc(nc1)C#Cc1cc(Cl)cc(c1)C#N
Show InChI InChI=1S/C15H9ClN2/c1-11-2-4-15(18-10-11)5-3-12-6-13(9-17)8-14(16)7-12/h2,4,6-8,10H,1H3
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n/an/a 1.22n/an/an/an/an/an/a



Institute for Neurodegenerative Disorders

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50345569
PNG
(3-(2-(pyridin-2-yl)ethynyl)-5-nitrobenzonitrile | ...)
Show SMILES [O-][N+](=O)c1cc(cc(c1)C#Cc1ccccn1)C#N
Show InChI InChI=1S/C14H7N3O2/c15-10-12-7-11(8-14(9-12)17(18)19)4-5-13-3-1-2-6-16-13/h1-3,6-9H
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n/an/a 1.32n/an/an/an/an/an/a



Institute for Neurodegenerative Disorders

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50216762
PNG
(3-chloro-5-(2-methylquinolin-7-yl)benzonitrile | C...)
Show SMILES Cc1ccc2ccc(cc2n1)-c1cc(Cl)cc(c1)C#N
Show InChI InChI=1S/C17H11ClN2/c1-11-2-3-13-4-5-14(9-17(13)20-11)15-6-12(10-19)7-16(18)8-15/h2-9H,1H3
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n/an/a 1.40n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50345558
PNG
(3-(2-(2-methylthiazol-4-yl)ethynyl)-1,5-dibromoben...)
Show SMILES Cc1nc(cs1)C#Cc1cc(Br)cc(Br)c1
Show InChI InChI=1S/C12H7Br2NS/c1-8-15-12(7-16-8)3-2-9-4-10(13)6-11(14)5-9/h4-7H,1H3
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n/an/a 1.45n/an/an/an/an/an/a



Institute for Neurodegenerative Disorders

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50066519
PNG
(CHEMBL3403102)
Show SMILES Fc1cc(cc(c1)S(=O)(=O)c1sc2ncccc2c1-c1ccccc1F)C#N
Show InChI InChI=1S/C20H10F2N2O2S2/c21-13-8-12(11-23)9-14(10-13)28(25,26)20-18(15-4-1-2-6-17(15)22)16-5-3-7-24-19(16)27-20/h1-10H
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n/an/a 1.5n/an/an/an/an/an/a



Gedeon Richter Plc

Curated by ChEMBL


Assay Description
Negative allosteric modulation of mGlu5 receptor in primary E17 rat embryo neuron assessed as ca2+ level by fluo-4/AM assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50216758
PNG
(3-methyl-5-(2-methylquinolin-7-yl)benzonitrile | C...)
Show SMILES Cc1cc(cc(c1)-c1ccc2ccc(C)nc2c1)C#N
Show InChI InChI=1S/C18H14N2/c1-12-7-14(11-19)9-17(8-12)16-6-5-15-4-3-13(2)20-18(15)10-16/h3-10H,1-2H3
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n/an/a 1.60n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50066730
PNG
(CHEMBL3403126)
Show SMILES Nc1cnc2sc(c(-c3ccccc3F)c2c1)S(=O)(=O)c1cc(F)cc(c1)C#N
Show InChI InChI=1S/C20H11F2N3O2S2/c21-12-5-11(9-23)6-14(7-12)29(26,27)20-18(15-3-1-2-4-17(15)22)16-8-13(24)10-25-19(16)28-20/h1-8,10H,24H2
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n/an/a 1.60n/an/an/an/an/an/a



Gedeon Richter Plc

Curated by ChEMBL


Assay Description
Negative allosteric modulation of mGlu5 receptor in primary E17 rat embryo neuron assessed as ca2+ level by fluo-4/AM assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50345552
PNG
(3-(2-(2-methylthiazol-4-yl)ethynyl)-5-chlorobenzon...)
Show SMILES Cc1nc(cs1)C#Cc1cc(Cl)cc(c1)C#N
Show InChI InChI=1S/C13H7ClN2S/c1-9-16-13(8-17-9)3-2-10-4-11(7-15)6-12(14)5-10/h4-6,8H,1H3
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n/an/a 1.61n/an/an/an/an/an/a



Institute for Neurodegenerative Disorders

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50345556
PNG
(3-(2-(2-methylthiazol-4-yl)ethynyl)-5-nitroiodoben...)
Show SMILES Cc1nc(cs1)C#Cc1cc(I)cc(c1)[N+]([O-])=O
Show InChI InChI=1S/C12H7IN2O2S/c1-8-14-11(7-18-8)3-2-9-4-10(13)6-12(5-9)15(16)17/h4-7H,1H3
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n/an/a 1.75n/an/an/an/an/an/a



Institute for Neurodegenerative Disorders

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50258612
PNG
(3-Fluoro-5-cyano-1-(2-methylthiazol-4-ylethynyl)be...)
Show SMILES Cc1nc(cs1)C#Cc1cc(F)cc(c1)C#N
Show InChI InChI=1S/C13H7FN2S/c1-9-16-13(8-17-9)3-2-10-4-11(7-15)6-12(14)5-10/h4-6,8H,1H3
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n/an/a 1.89n/an/an/an/an/an/a



Institute for Neurodegenerative Disorders

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50332965
PNG
(4-(3-(2-cyclopropyl-6-methylpyridin-4-yl)phenyl)-7...)
Show SMILES Cc1cc(cc(n1)C1CC1)-c1cccc(c1)C1=Nc2cc(C)c(cc2NC(=O)C1)C(F)(F)F
Show InChI InChI=1S/C26H22F3N3O/c1-14-8-23-24(12-20(14)26(27,28)29)32-25(33)13-22(31-23)18-5-3-4-17(10-18)19-9-15(2)30-21(11-19)16-6-7-16/h3-5,8-12,16H,6-7,13H2,1-2H3,(H,32,33)
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n/an/a 2n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Partial displacement of [3H]LY354740 from recombinant rat mGluR2


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50216749
PNG
(3-(methoxymethyl)-5-(2-methylquinolin-7-yl)benzoni...)
Show SMILES COCc1cc(cc(c1)-c1ccc2ccc(C)nc2c1)C#N
Show InChI InChI=1S/C19H16N2O/c1-13-3-4-16-5-6-17(10-19(16)21-13)18-8-14(11-20)7-15(9-18)12-22-2/h3-10H,12H2,1-2H3
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n/an/a 2n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50216750
PNG
(5-(2-methylquinolin-7-yl)isophthalonitrile | CHEMB...)
Show SMILES Cc1ccc2ccc(cc2n1)-c1cc(cc(c1)C#N)C#N
Show InChI InChI=1S/C18H11N3/c1-12-2-3-15-4-5-16(9-18(15)21-12)17-7-13(10-19)6-14(8-17)11-20/h2-9H,1H3
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n/an/a 2n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50163617
PNG
((2,3-Dihydro-thieno[2,3-b]quinolin-6-yl)-(4-methox...)
Show SMILES CO[C@H]1CC[C@H](CC1)C(=O)c1ccc2nc3SCCc3cc2c1
Show InChI InChI=1S/C19H21NO2S/c1-22-16-5-2-12(3-6-16)18(21)13-4-7-17-15(10-13)11-14-8-9-23-19(14)20-17/h4,7,10-12,16H,2-3,5-6,8-9H2,1H3/t12-,16+
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n/an/a 2n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat metabotropic glutamate receptor 1


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50332964
PNG
(4-(3-(2-ethyl-6-methylpyridin-4-yl)phenyl)-7-methy...)
Show SMILES CCc1cc(cc(C)n1)-c1cccc(c1)C1=Nc2cc(C)c(cc2NC(=O)C1)C(F)(F)F
Show InChI InChI=1S/C25H22F3N3O/c1-4-19-11-18(9-15(3)29-19)16-6-5-7-17(10-16)21-13-24(32)31-23-12-20(25(26,27)28)14(2)8-22(23)30-21/h5-12H,4,13H2,1-3H3,(H,31,32)
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n/an/a 2n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Partial displacement of [3H]LY354740 from recombinant rat mGluR2


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50332966
PNG
(7,8-dichloro-4-(3-(2-methylpyridin-4-yl)phenyl)-1H...)
Show SMILES Cc1cc(ccn1)-c1cccc(c1)C1=Nc2cc(Cl)c(Cl)cc2NC(=O)C1
Show InChI InChI=1S/C21H15Cl2N3O/c1-12-7-14(5-6-24-12)13-3-2-4-15(8-13)18-11-21(27)26-20-10-17(23)16(22)9-19(20)25-18/h2-10H,11H2,1H3,(H,26,27)
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F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat mGluR2 expressed in forskolin-stimulated CHO cells assessed as inhibition of (1S,3R)-ACPD induced cAMP product...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50332962
PNG
(7-methyl-4-(3-(pyridin-3-yl)phenyl)-8-(trifluorome...)
Show SMILES Cc1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(c1)-c1cccnc1
Show InChI InChI=1S/C22H16F3N3O/c1-13-8-19-20(10-17(13)22(23,24)25)28-21(29)11-18(27-19)15-5-2-4-14(9-15)16-6-3-7-26-12-16/h2-10,12H,11H2,1H3,(H,28,29)
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F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Partial displacement of [3H]LY354740 from recombinant rat mGluR2


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50332963
PNG
(4-(3-(2,6-dimethylpyridin-4-yl)phenyl)-7-methyl-8-...)
Show SMILES Cc1cc(cc(C)n1)-c1cccc(c1)C1=Nc2cc(C)c(cc2NC(=O)C1)C(F)(F)F
Show InChI InChI=1S/C24H20F3N3O/c1-13-7-21-22(11-19(13)24(25,26)27)30-23(31)12-20(29-21)17-6-4-5-16(10-17)18-8-14(2)28-15(3)9-18/h4-11H,12H2,1-3H3,(H,30,31)
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F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Partial displacement of [3H]LY354740 from recombinant rat mGluR2


Citation and Details
More data for this
Ligand-Target Pair
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