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Compile Data Set for Download or QSAR

Found 928 hits Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 2'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50062522
PNG
((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)
Show SMILES N[C@@](CC1c2ccccc2Oc2ccccc12)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C20H19NO5/c21-20(19(24)25,15-9-13(15)18(22)23)10-14-11-5-1-3-7-16(11)26-17-8-4-2-6-12(14)17/h1-8,13-15H,9-10,21H2,(H,22,23)(H,24,25)/t13-,15-,20-/m0/s1
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n/an/a 2.90n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]-MGS0008 from mGluR2 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50376408
PNG
(CHEMBL409928)
Show SMILES N[C@@](CC1c2ccccc2Oc2ccccc12)([C@H]1C[C@]1(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C20H18FNO5/c21-19(17(23)24)10-16(19)20(22,18(25)26)9-13-11-5-1-3-7-14(11)27-15-8-4-2-6-12(13)15/h1-8,13,16H,9-10,22H2,(H,23,24)(H,25,26)/t16-,19+,20-/m0/s1
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n/an/a 3.49n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]-MGS0008 from mGluR2 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50376406
PNG
(CHEMBL259435)
Show SMILES NC(CC1c2ccccc2Oc2ccccc12)(C1CC1(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C20H18FNO5/c21-19(17(23)24)10-16(19)20(22,18(25)26)9-13-11-5-1-3-7-14(11)27-15-8-4-2-6-12(13)15/h1-8,13,16H,9-10,22H2,(H,23,24)(H,25,26)
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n/an/a 4.45n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]-MGS0008 from mGluR2 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50056272
PNG
((1S,2S,5R,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dic...)
Show SMILES N[C@]1(CC[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-8(7(12)13)2-1-3-4(5(3)8)6(10)11/h3-5H,1-2,9H2,(H,10,11)(H,12,13)/t3-,4-,5-,8-/m0/s1
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n/an/a 5.60n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human mGlu2 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 assessed as inhibition of forskolin-stim...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50401385
PNG
(CHEMBL2206447)
Show SMILES COc1cc(F)cc(F)c1C1CCN(CC1)c1ccn2c(CC3CC3)nnc2c1Cl
Show InChI InChI=1S/C22H23ClF2N4O/c1-30-18-12-15(24)11-16(25)20(18)14-4-7-28(8-5-14)17-6-9-29-19(10-13-2-3-13)26-27-22(29)21(17)23/h6,9,11-14H,2-5,7-8,10H2,1H3
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n/an/a 5.60n/an/an/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Displacement of [3H]JNJ-40068782 from human mGLuR2 expressed in CHO cell membrane after 60 mins by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50081052
PNG
(CHEMBL3421840)
Show SMILES C[C@H]1CN(C(=O)c2c(cnn12)-c1ccnc(c1)C#N)c1ccc(c(Cl)c1)C(F)(F)F
Show InChI InChI=1/C20H13ClF3N5O/c1-11-10-28(14-2-3-16(17(21)7-14)20(22,23)24)19(30)18-15(9-27-29(11)18)12-4-5-26-13(6-12)8-25/h2-7,9,11H,10H2,1H3/t11-/s2
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n/an/a 6.90n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR2 receptor expressed in CHO cell membranes assessed as inhibition of glutamate responses after 30 mins b...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50332966
PNG
(7,8-dichloro-4-(3-(2-methylpyridin-4-yl)phenyl)-1H...)
Show SMILES Cc1cc(ccn1)-c1cccc(c1)C1=Nc2cc(Cl)c(Cl)cc2NC(=O)C1
Show InChI InChI=1S/C21H15Cl2N3O/c1-12-7-14(5-6-24-12)13-3-2-4-15(8-13)18-11-21(27)26-20-10-17(23)16(22)9-19(20)25-18/h2-10H,11H2,1H3,(H,26,27)
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n/an/a 7n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human mGluR2 receptor expressed in CHO cells assessed as inhibition of GIRK current


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50401386
PNG
(CHEMBL2206446)
Show SMILES COc1ccc(F)c(F)c1C1CCN(CC1)c1ccn2c(CC3CC3)nnc2c1Cl
Show InChI InChI=1S/C22H23ClF2N4O/c1-30-17-5-4-15(24)21(25)19(17)14-6-9-28(10-7-14)16-8-11-29-18(12-13-2-3-13)26-27-22(29)20(16)23/h4-5,8,11,13-14H,2-3,6-7,9-10,12H2,1H3
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n/an/a 7.30n/an/an/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Displacement of [3H]JNJ-40068782 from human mGLuR2 expressed in CHO cell membrane after 60 mins by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50081051
PNG
(CHEMBL3421838)
Show SMILES C[C@H]1CN(C(=O)c2c(cnn12)-c1ccnc(C)c1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1/C20H17F3N4O/c1-12-9-14(7-8-24-12)17-10-25-27-13(2)11-26(19(28)18(17)27)16-5-3-15(4-6-16)20(21,22)23/h3-10,13H,11H2,1-2H3/t13-/s2
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n/an/a 8.90n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR2 receptor expressed in CHO cell membranes assessed as inhibition of glutamate responses after 30 mins b...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50401387
PNG
(CHEMBL2206445)
Show SMILES COc1c(F)ccc(F)c1C1CCN(CC1)c1ccn2c(CC3CC3)nnc2c1Cl
Show InChI InChI=1S/C22H23ClF2N4O/c1-30-21-16(25)5-4-15(24)19(21)14-6-9-28(10-7-14)17-8-11-29-18(12-13-2-3-13)26-27-22(29)20(17)23/h4-5,8,11,13-14H,2-3,6-7,9-10,12H2,1H3
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n/an/a 9.23n/an/an/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Displacement of [3H]JNJ-40068782 from human mGLuR2 expressed in CHO cell membrane after 60 mins by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50332967
PNG
(8-chloro-4-(3-(pyridin-4-yl)phenyl)-1H-benzo[b][1,...)
Show SMILES Clc1ccc2N=C(CC(=O)Nc2c1)c1cccc(c1)-c1ccncc1
Show InChI InChI=1S/C20H14ClN3O/c21-16-4-5-17-19(11-16)24-20(25)12-18(23-17)15-3-1-2-14(10-15)13-6-8-22-9-7-13/h1-11H,12H2,(H,24,25)
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n/an/a 10n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human mGluR2 receptor expressed in CHO cells assessed as inhibition of GIRK current


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50401388
PNG
(CHEMBL2206442)
Show SMILES COc1cccc(F)c1C1CCN(CC1)c1ccn2c(CC3CC3)nnc2c1Cl
Show InChI InChI=1S/C22H24ClFN4O/c1-29-18-4-2-3-16(24)20(18)15-7-10-27(11-8-15)17-9-12-28-19(13-14-5-6-14)25-26-22(28)21(17)23/h2-4,9,12,14-15H,5-8,10-11,13H2,1H3
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n/an/a 11.2n/an/an/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Displacement of [3H]JNJ-40068782 from human mGLuR2 expressed in CHO cell membrane after 60 mins by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50401389
PNG
(CHEMBL2206441)
Show SMILES COc1ccc(F)cc1C1CCN(CC1)c1ccn2c(CC3CC3)nnc2c1Cl
Show InChI InChI=1S/C22H24ClFN4O/c1-29-19-5-4-16(24)13-17(19)15-6-9-27(10-7-15)18-8-11-28-20(12-14-2-3-14)25-26-22(28)21(18)23/h4-5,8,11,13-15H,2-3,6-7,9-10,12H2,1H3
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n/an/a 11.2n/an/an/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Displacement of [3H]JNJ-40068782 from human mGLuR2 expressed in CHO cell membrane after 60 mins by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50332963
PNG
(4-(3-(2,6-dimethylpyridin-4-yl)phenyl)-7-methyl-8-...)
Show SMILES Cc1cc(cc(C)n1)-c1cccc(c1)C1=Nc2cc(C)c(cc2NC(=O)C1)C(F)(F)F
Show InChI InChI=1S/C24H20F3N3O/c1-13-7-21-22(11-19(13)24(25,26)27)30-23(31)12-20(29-21)17-6-4-5-16(10-17)18-8-14(2)28-15(3)9-18/h4-11H,12H2,1-3H3,(H,30,31)
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n/an/a 14n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human mGluR2 receptor expressed in CHO cells assessed as inhibition of GIRK current


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50332968
PNG
(7-ethoxy-4-(3-(2-methylpyridin-4-yl)phenyl)-8-(tri...)
Show SMILES CCOc1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(c1)-c1ccnc(C)c1
Show InChI InChI=1S/C24H20F3N3O2/c1-3-32-22-12-21-20(11-18(22)24(25,26)27)30-23(31)13-19(29-21)17-6-4-5-15(10-17)16-7-8-28-14(2)9-16/h4-12H,3,13H2,1-2H3,(H,30,31)
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n/an/a 15n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human mGluR2 receptor expressed in CHO cells assessed as inhibition of GIRK current


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50399088
PNG
(CHEMBL2179319)
Show SMILES FC(F)(F)c1c(ccn2c(CC3CC3)nnc12)N1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C22H23F3N4/c23-22(24,25)20-18(10-13-29-19(14-15-6-7-15)26-27-21(20)29)28-11-8-17(9-12-28)16-4-2-1-3-5-16/h1-5,10,13,15,17H,6-9,11-12,14H2
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n/an/a 15n/an/an/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Binding affinity to human mGlu2R expressed in CHO cells by radioligand binding assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50151435
PNG
((1R,2R,3R,5R,6R)-2-Amino-3-(3,4-dichloro-benzyloxy...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1ccc(Cl)c(Cl)c1)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H14Cl2FNO5/c16-8-2-1-6(3-9(8)17)5-24-10-4-7-11(14(7,18)12(20)21)15(10,19)13(22)23/h1-3,7,10-11H,4-5,19H2,(H,20,21)(H,22,23)/t7-,10-,11+,14-,15+/m1/s1
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n/an/a 20n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Antagonist activity at mGLUR2 expressed in CHO cells assessed as inhibition of glutamate-induced inhibition of forskolin-stimulated cAMP production


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50062522
PNG
((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)
Show SMILES N[C@@](CC1c2ccccc2Oc2ccccc12)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C20H19NO5/c21-20(19(24)25,15-9-13(15)18(22)23)10-14-11-5-1-3-7-16(11)26-17-8-4-2-6-12(14)17/h1-8,13-15H,9-10,21H2,(H,22,23)(H,24,25)/t13-,15-,20-/m0/s1
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n/an/a 21n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Antagonist activity at human mGLUR2 expressed in RGT cells assessed as inhibition of (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid-induced inhibi...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50062522
PNG
((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)
Show SMILES N[C@@](CC1c2ccccc2Oc2ccccc12)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C20H19NO5/c21-20(19(24)25,15-9-13(15)18(22)23)10-14-11-5-1-3-7-16(11)26-17-8-4-2-6-12(14)17/h1-8,13-15H,9-10,21H2,(H,22,23)(H,24,25)/t13-,15-,20-/m0/s1
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n/an/a 23n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 2


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50333000
PNG
(4-(3-(2-methylpyridin-4-yl)phenyl)-8-(trifluoromet...)
Show SMILES Cc1cc(ccn1)-c1cccc(c1)C1=Nc2ccc(cc2NC(=O)C1)C(F)(F)F
Show InChI InChI=1S/C22H16F3N3O/c1-13-9-15(7-8-26-13)14-3-2-4-16(10-14)19-12-21(29)28-20-11-17(22(23,24)25)5-6-18(20)27-19/h2-11H,12H2,1H3,(H,28,29)
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n/an/a 25n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human mGluR2 receptor expressed in CHO cells assessed as inhibition of GIRK current


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50076389
PNG
((1S,2S)-2-[(R)-Amino-carboxy-(9-methyl-9H-xanthen-...)
Show SMILES CC1c2ccccc2Oc2cccc(c12)[C@](N)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C20H19NO5/c1-10-11-5-2-3-7-15(11)26-16-8-4-6-13(17(10)16)20(21,19(24)25)14-9-12(14)18(22)23/h2-8,10,12,14H,9,21H2,1H3,(H,22,23)(H,24,25)/t10?,12-,14-,20-/m0/s1
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n/an/a 34n/an/an/an/an/an/a



Parc Club Orsay Université

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human Metabotropic glutamate receptor 2


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50332972
PNG
(7-ethoxy-4-(3-(pyridin-4-yl)phenyl)-8-(trifluorome...)
Show SMILES CCOc1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(c1)-c1ccncc1
Show InChI InChI=1S/C23H18F3N3O2/c1-2-31-21-12-20-19(11-17(21)23(24,25)26)29-22(30)13-18(28-20)16-5-3-4-15(10-16)14-6-8-27-9-7-14/h3-12H,2,13H2,1H3,(H,29,30)
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n/an/a 38n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human mGluR2 receptor expressed in CHO cells assessed as inhibition of GIRK current


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50332970
PNG
(7-methyl-4-(3-(2-methylpyridin-4-yl)phenyl)-8-(tri...)
Show SMILES Cc1cc(ccn1)-c1cccc(c1)C1=Nc2cc(C)c(cc2NC(=O)C1)C(F)(F)F
Show InChI InChI=1S/C23H18F3N3O/c1-13-8-20-21(11-18(13)23(24,25)26)29-22(30)12-19(28-20)17-5-3-4-15(10-17)16-6-7-27-14(2)9-16/h3-11H,12H2,1-2H3,(H,29,30)
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n/an/a 41n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human mGluR2 receptor expressed in CHO cells assessed as inhibition of GIRK current


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50332989
PNG
(4-(3-(pyridin-4-yl)phenyl)-8-(trifluoromethyl)-1H-...)
Show SMILES FC(F)(F)c1ccc2N=C(CC(=O)Nc2c1)c1cccc(c1)-c1ccncc1
Show InChI InChI=1S/C21H14F3N3O/c22-21(23,24)16-4-5-17-19(11-16)27-20(28)12-18(26-17)15-3-1-2-14(10-15)13-6-8-25-9-7-13/h1-11H,12H2,(H,27,28)
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n/an/a 52n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human mGluR2 receptor expressed in CHO cells assessed as inhibition of GIRK current


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50051408
PNG
(CHEMBL3337527)
Show SMILES CCCCn1ccc(N2CCC(CC2)c2ccccc2)c(Cl)c1=O
Show InChI InChI=1S/C20H25ClN2O/c1-2-3-12-23-15-11-18(19(21)20(23)24)22-13-9-17(10-14-22)16-7-5-4-6-8-16/h4-8,11,15,17H,2-3,9-10,12-14H2,1H3
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n/an/a 68n/an/an/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Displacement of [3H]19 from human mGlu2 receptor expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50081048
PNG
(CHEMBL3421839)
Show SMILES CCC1CN(C(=O)c2c(cnn12)-c1ccnc(C)c1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1/C21H19F3N4O/c1-3-16-12-27(17-6-4-15(5-7-17)21(22,23)24)20(29)19-18(11-26-28(16)19)14-8-9-25-13(2)10-14/h4-11,16H,3,12H2,1-2H3
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n/an/a 79n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR2 receptor expressed in CHO cell membranes assessed as inhibition of glutamate responses after 30 mins b...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50062520
PNG
((1S,2S)-2-((R)-1-Amino-1-carboxy-3-m-tolyl-propyl)...)
Show SMILES Cc1cccc(CC[C@@](N)([C@H]2C[C@@H]2C(O)=O)C(O)=O)c1
Show InChI InChI=1S/C15H19NO4/c1-9-3-2-4-10(7-9)5-6-15(16,14(19)20)12-8-11(12)13(17)18/h2-4,7,11-12H,5-6,8,16H2,1H3,(H,17,18)(H,19,20)/t11-,12-,15+/m0/s1
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n/an/a 180n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 2


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50062518
PNG
((S)-2-[(R)-1-Amino-1-carboxy-3-(3-chloro-phenyl)-p...)
Show SMILES N[C@](CCc1cccc(Cl)c1)(C1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C14H16ClNO4/c15-9-3-1-2-8(6-9)4-5-14(16,13(19)20)11-7-10(11)12(17)18/h1-3,6,10-11H,4-5,7,16H2,(H,17,18)(H,19,20)/t10-,11?,14+/m0/s1
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 2


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50062526
PNG
((S)-2-[(R)-1-Amino-1-carboxy-3-(4-fluoro-phenyl)-p...)
Show SMILES N[C@](CCc1ccc(F)cc1)(C1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C14H16FNO4/c15-9-3-1-8(2-4-9)5-6-14(16,13(19)20)11-7-10(11)12(17)18/h1-4,10-11H,5-7,16H2,(H,17,18)(H,19,20)/t10-,11?,14+/m0/s1
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n/an/a 180n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 2


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50408696
PNG
(CHEMBL2111822)
Show SMILES CS(=O)(=O)c1cccc(CC[C@@](N)(C2C[C@@H]2C(O)=O)C(O)=O)c1
Show InChI InChI=1S/C15H19NO6S/c1-23(21,22)10-4-2-3-9(7-10)5-6-15(16,14(19)20)12-8-11(12)13(17)18/h2-4,7,11-12H,5-6,8,16H2,1H3,(H,17,18)(H,19,20)/t11-,12?,15+/m0/s1
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n/an/a 190n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 2


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50062522
PNG
((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)
Show SMILES N[C@@](CC1c2ccccc2Oc2ccccc12)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C20H19NO5/c21-20(19(24)25,15-9-13(15)18(22)23)10-14-11-5-1-3-7-16(11)26-17-8-4-2-6-12(14)17/h1-8,13-15H,9-10,21H2,(H,22,23)(H,24,25)/t13-,15-,20-/m0/s1
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n/an/a 200n/an/an/an/an/an/a



Universit£ di Perugia

Curated by ChEMBL


Assay Description
Antagonistic activity against stimulation of GTP (gamma) 35 S binding by glutamate in membranes from CHO cells expressing human mGluR2


Bioorg Med Chem Lett 11: 3179-82 (2001)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50279772
PNG
(2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-cy...)
Show SMILES N[C@](CC1c2ccccc2Oc2ccccc12)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C20H19NO5/c21-20(19(24)25,15-9-13(15)18(22)23)10-14-11-5-1-3-7-16(11)26-17-8-4-2-6-12(14)17/h1-8,13-15H,9-10,21H2,(H,22,23)(H,24,25)/t13-,15-,20+/m0/s1
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Ability to block 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in non-neuronal cell line expressing human Metabotropic glutamate r...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50107108
PNG
((1S,2S,3R)-2-(Amino-carboxy-methyl)-3-[2-(9H-xanth...)
Show SMILES NC([C@H]1[C@@H](CCC2c3ccccc3Oc3ccccc23)[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C21H21NO5/c22-19(21(25)26)17-14(18(17)20(23)24)10-9-11-12-5-1-3-7-15(12)27-16-8-4-2-6-13(11)16/h1-8,11,14,17-19H,9-10,22H2,(H,23,24)(H,25,26)/t14-,17+,18+,19?/m1/s1
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Universit£ di Perugia

Curated by ChEMBL


Assay Description
Antagonistic activity against stimulation of GTP (gamma) 35 S binding by glutamate in membranes from CHO cells expressing human Metabotropic glutamat...


Bioorg Med Chem Lett 11: 3179-82 (2001)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50376406
PNG
(CHEMBL259435)
Show SMILES NC(CC1c2ccccc2Oc2ccccc12)(C1CC1(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C20H18FNO5/c21-19(17(23)24)10-16(19)20(22,18(25)26)9-13-11-5-1-3-7-14(11)27-15-8-4-2-6-12(13)15/h1-8,13,16H,9-10,22H2,(H,23,24)(H,25,26)
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n/an/a 211n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]-MGS0008 from mGluR2 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50062538
PNG
((S)-2-[(R)-1-Amino-1-carboxy-3-(3-trifluoromethyl-...)
Show SMILES N[C@](CCc1cccc(c1)C(F)(F)F)(C1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C15H16F3NO4/c16-15(17,18)9-3-1-2-8(6-9)4-5-14(19,13(22)23)11-7-10(11)12(20)21/h1-3,6,10-11H,4-5,7,19H2,(H,20,21)(H,22,23)/t10-,11?,14+/m0/s1
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n/an/a 220n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 2


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50062543
PNG
((1S,2S)-2-((S)-1-Amino-1-carboxy-3,3-diphenyl-prop...)
Show SMILES N[C@@](CC(c1ccccc1)c1ccccc1)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C20H21NO4/c21-20(19(24)25,17-11-15(17)18(22)23)12-16(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10,15-17H,11-12,21H2,(H,22,23)(H,24,25)/t15-,17-,20-/m0/s1
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 2


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50408688
PNG
(CHEMBL2112586)
Show SMILES NC(CCC12CC3CC(CC(C3)C1)C2)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C18H27NO4/c19-18(16(22)23,14-6-13(14)15(20)21)2-1-17-7-10-3-11(8-17)5-12(4-10)9-17/h10-14H,1-9,19H2,(H,20,21)(H,22,23)/t10?,11?,12?,13-,14-,17?,18?/m0/s1
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Ability to block 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in non-neuronal cell line expressing human Metabotropic glutamate r...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50408687
PNG
(CHEMBL2112583)
Show SMILES NC(CCc1cccc2ccccc12)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C18H19NO4/c19-18(17(22)23,15-10-14(15)16(20)21)9-8-12-6-3-5-11-4-1-2-7-13(11)12/h1-7,14-15H,8-10,19H2,(H,20,21)(H,22,23)/t14-,15-,18?/m0/s1
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Ability to block 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in non-neuronal cell line expressing human Metabotropic glutamate r...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50332963
PNG
(4-(3-(2,6-dimethylpyridin-4-yl)phenyl)-7-methyl-8-...)
Show SMILES Cc1cc(cc(C)n1)-c1cccc(c1)C1=Nc2cc(C)c(cc2NC(=O)C1)C(F)(F)F
Show InChI InChI=1S/C24H20F3N3O/c1-13-7-21-22(11-19(13)24(25,26)27)30-23(31)12-20(29-21)17-6-4-5-16(10-17)18-8-14(2)28-15(3)9-18/h4-11H,12H2,1-3H3,(H,30,31)
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of mGlu2 receptor (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50332963
PNG
(4-(3-(2,6-dimethylpyridin-4-yl)phenyl)-7-methyl-8-...)
Show SMILES Cc1cc(cc(C)n1)-c1cccc(c1)C1=Nc2cc(C)c(cc2NC(=O)C1)C(F)(F)F
Show InChI InChI=1S/C24H20F3N3O/c1-13-7-21-22(11-19(13)24(25,26)27)30-23(31)12-20(29-21)17-6-4-5-16(10-17)18-8-14(2)28-15(3)9-18/h4-11H,12H2,1-3H3,(H,30,31)
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of mGlu2 by cell-based assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50049748
PNG
((2S,4S)-2-Amino-4-(4,4-diphenyl-butyl)-pentanedioi...)
Show SMILES N[C@@H](C[C@H](CCCC(c1ccccc1)c1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C21H25NO4/c22-19(21(25)26)14-17(20(23)24)12-7-13-18(15-8-3-1-4-9-15)16-10-5-2-6-11-16/h1-6,8-11,17-19H,7,12-14,22H2,(H,23,24)(H,25,26)/t17-,19-/m0/s1
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n/an/a 400n/an/an/an/an/an/a



Parc Club Orsay Université

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human Metabotropic glutamate receptor 2


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50062534
PNG
((S)-2-[(R)-1-Amino-1-carboxy-3-(3-methoxy-phenyl)-...)
Show SMILES COc1cccc(CC[C@@](N)(C2C[C@@H]2C(O)=O)C(O)=O)c1
Show InChI InChI=1S/C15H19NO5/c1-21-10-4-2-3-9(7-10)5-6-15(16,14(19)20)12-8-11(12)13(17)18/h2-4,7,11-12H,5-6,8,16H2,1H3,(H,17,18)(H,19,20)/t11-,12?,15+/m0/s1
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 2


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50408690
PNG
(CHEMBL2112585)
Show SMILES NC(CCCCc1ccccc1)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C16H21NO4/c17-16(15(20)21,13-10-12(13)14(18)19)9-5-4-8-11-6-2-1-3-7-11/h1-3,6-7,12-13H,4-5,8-10,17H2,(H,18,19)(H,20,21)/t12-,13-,16?/m0/s1
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n/an/a 450n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Ability to block 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in non-neuronal cell line expressing human Metabotropic glutamate r...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50332632
PNG
(CHEMBL1630805 | N-(4-Chlorophenyl)-7-oxo-7,7a-dihy...)
Show SMILES Clc1ccc(NC(=O)C23CC2C(N=O)c2ccccc2O3)cc1
Show InChI InChI=1S/C17H13ClN2O3/c18-10-5-7-11(8-6-10)19-16(21)17-9-13(17)15(20-22)12-3-1-2-4-14(12)23-17/h1-8,13,15H,9H2,(H,19,21)
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n/an/a 800n/an/an/an/an/an/a



Domain Therapeutics SA

Curated by ChEMBL


Assay Description
Negative allosteric modulator activity at human mGluR2 expressed in HEK cells in presence of glutamate EC80 concentration by Ca2+ functional assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50408693
PNG
(CHEMBL2112582)
Show SMILES NC(CCc1ccccc1)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C14H17NO4/c15-14(13(18)19,11-8-10(11)12(16)17)7-6-9-4-2-1-3-5-9/h1-5,10-11H,6-8,15H2,(H,16,17)(H,18,19)/t10-,11-,14?/m0/s1
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n/an/a 850n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Ability to block 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in non-neuronal cell line expressing human Metabotropic glutamate r...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50408693
PNG
(CHEMBL2112582)
Show SMILES NC(CCc1ccccc1)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C14H17NO4/c15-14(13(18)19,11-8-10(11)12(16)17)7-6-9-4-2-1-3-5-9/h1-5,10-11H,6-8,15H2,(H,16,17)(H,18,19)/t10-,11-,14?/m0/s1
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n/an/a 850n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 2


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50062529
PNG
((S)-2-[(R)-1-Amino-1-carboxy-3-(3-hydroxy-phenyl)-...)
Show SMILES N[C@](CCc1cccc(O)c1)(C1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C14H17NO5/c15-14(13(19)20,11-7-10(11)12(17)18)5-4-8-2-1-3-9(16)6-8/h1-3,6,10-11,16H,4-5,7,15H2,(H,17,18)(H,19,20)/t10-,11?,14+/m0/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 2


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50408692
PNG
(CHEMBL2112584)
Show SMILES NC(CCCc1ccccc1)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C15H19NO4/c16-15(14(19)20,12-9-11(12)13(17)18)8-4-7-10-5-2-1-3-6-10/h1-3,5-6,11-12H,4,7-9,16H2,(H,17,18)(H,19,20)/t11-,12-,15?/m0/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Ability to block 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in non-neuronal cell line expressing human Metabotropic glutamate r...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50408694
PNG
(CHEMBL2112581)
Show SMILES NC(CCc1ccsc1)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C12H15NO4S/c13-12(11(16)17,9-5-8(9)10(14)15)3-1-7-2-4-18-6-7/h2,4,6,8-9H,1,3,5,13H2,(H,14,15)(H,16,17)/t8-,9-,12?/m0/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Ability to block 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in non-neuronal cell line expressing human Metabotropic glutamate r...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50332634
PNG
(CHEMBL1630807 | N-(4-Methoxyphenyl)-7-oxo-7,7a-dih...)
Show SMILES COc1ccc(NC(=O)C23CC2C(N=O)c2ccccc2O3)cc1
Show InChI InChI=1S/C18H16N2O4/c1-23-12-8-6-11(7-9-12)19-17(21)18-10-14(18)16(20-22)13-4-2-3-5-15(13)24-18/h2-9,14,16H,10H2,1H3,(H,19,21)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Domain Therapeutics SA

Curated by ChEMBL


Assay Description
Negative allosteric modulator activity at human mGluR2 expressed in HEK cells in presence of glutamate EC80 concentration by Ca2+ functional assay


Citation and Details
More data for this
Ligand-Target Pair
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