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Compile Data Set for Download or QSAR

Found 1493 hits Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 3'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM50332968
PNG
(7-ethoxy-4-(3-(2-methylpyridin-4-yl)phenyl)-8-(tri...)
Show SMILES CCOc1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(c1)-c1ccnc(C)c1
Show InChI InChI=1S/C24H20F3N3O2/c1-3-32-22-12-21-20(11-18(22)24(25,26)27)30-23(31)13-19(29-21)17-6-4-5-15(10-17)16-7-8-28-14(2)9-16/h4-12H,3,13H2,1-2H3,(H,30,31)
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n/an/a 3n/an/an/an/an/an/a



F. Hoffmann-La Roche Inc

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR3 receptor expressed in CHO cells assessed as inhibition of GIRK current


Bioorg Med Chem Lett 20: 6969-74 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.125
BindingDB Entry DOI: 10.7270/Q2X63N6R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM50332972
PNG
(7-ethoxy-4-(3-(pyridin-4-yl)phenyl)-8-(trifluorome...)
Show SMILES CCOc1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(c1)-c1ccncc1
Show InChI InChI=1S/C23H18F3N3O2/c1-2-31-21-12-20-19(11-17(21)23(24,25)26)29-22(30)13-18(28-20)16-5-3-4-15(10-16)14-6-8-27-9-7-14/h3-12H,2,13H2,1H3,(H,29,30)
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n/an/a 6n/an/an/an/an/an/a



F. Hoffmann-La Roche Inc

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR3 receptor expressed in CHO cells assessed as inhibition of GIRK current


Bioorg Med Chem Lett 20: 6969-74 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.125
BindingDB Entry DOI: 10.7270/Q2X63N6R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM50062522
PNG
((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)
Show SMILES N[C@@](CC1c2ccccc2Oc2ccccc12)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C20H19NO5/c21-20(19(24)25,15-9-13(15)18(22)23)10-14-11-5-1-3-7-16(11)26-17-8-4-2-6-12(14)17/h1-8,13-15H,9-10,21H2,(H,22,23)(H,24,25)/t13-,15-,20-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3


J Med Chem 41: 358-78 (1998)


Article DOI: 10.1021/jm970498o
BindingDB Entry DOI: 10.7270/Q2XP7423
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM50332970
PNG
(7-methyl-4-(3-(2-methylpyridin-4-yl)phenyl)-8-(tri...)
Show SMILES Cc1cc(ccn1)-c1cccc(c1)C1=Nc2cc(C)c(cc2NC(=O)C1)C(F)(F)F
Show InChI InChI=1S/C23H18F3N3O/c1-13-8-20-21(11-18(13)23(24,25)26)29-22(30)12-19(28-20)17-5-3-4-15(10-17)16-6-7-27-14(2)9-16/h3-11H,12H2,1-2H3,(H,29,30)
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n/an/a 14n/an/an/an/an/an/a



F. Hoffmann-La Roche Inc

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR3 receptor expressed in CHO cells assessed as inhibition of GIRK current


Bioorg Med Chem Lett 20: 6969-74 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.125
BindingDB Entry DOI: 10.7270/Q2X63N6R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM50204259
PNG
(CHEMBL3913414)
Show SMILES CC(=O)N[C@H]1[C@H]2[C@@H]([C@H]2[C@@](N)([C@@H]1OCc1ccc(Cl)c(Cl)c1)C(O)=O)C(O)=O
Show InChI InChI=1/C17H18Cl2N2O6/c1-6(22)21-13-10-11(15(23)24)12(10)17(20,16(25)26)14(13)27-5-7-2-3-8(18)9(19)4-7/h2-4,10-14H,5,20H2,1H3,(H,21,22)(H,23,24)(H,25,26)/t10-,11-,12-,13-,14+,17+/s2
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n/an/a 14n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human mGlu3 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as reduction of DCG-4-inhi...


Bioorg Med Chem Lett 26: 5663-5668 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.067
BindingDB Entry DOI: 10.7270/Q2JS9SDT
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM50062522
PNG
((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)
Show SMILES N[C@@](CC1c2ccccc2Oc2ccccc12)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C20H19NO5/c21-20(19(24)25,15-9-13(15)18(22)23)10-14-11-5-1-3-7-16(11)26-17-8-4-2-6-12(14)17/h1-8,13-15H,9-10,21H2,(H,22,23)(H,24,25)/t13-,15-,20-/m0/s1
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n/an/a 14n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Antagonist activity at human mGLUR3 expressed in RGT cells assessed as inhibition of (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid-induced inhibi...


Bioorg Med Chem Lett 22: 1958-62 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.039
BindingDB Entry DOI: 10.7270/Q2T72JJ1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM50062522
PNG
((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)
Show SMILES N[C@@](CC1c2ccccc2Oc2ccccc12)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C20H19NO5/c21-20(19(24)25,15-9-13(15)18(22)23)10-14-11-5-1-3-7-16(11)26-17-8-4-2-6-12(14)17/h1-8,13-15H,9-10,21H2,(H,22,23)(H,24,25)/t13-,15-,20-/m0/s1
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n/an/a 14.2n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Concentration required to inhibit metabotropic glutamate receptor 3 activity of rat expressed in CHO cells


J Med Chem 47: 4570-87 (2004)


Article DOI: 10.1021/jm0400294
BindingDB Entry DOI: 10.7270/Q2GH9HFK
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM50062522
PNG
((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)
Show SMILES N[C@@](CC1c2ccccc2Oc2ccccc12)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C20H19NO5/c21-20(19(24)25,15-9-13(15)18(22)23)10-14-11-5-1-3-7-16(11)26-17-8-4-2-6-12(14)17/h1-8,13-15H,9-10,21H2,(H,22,23)(H,24,25)/t13-,15-,20-/m0/s1
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n/an/a 16n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonistic activity against metabotropic glutamate receptor 3 (mGluR3) was evaluated


Bioorg Med Chem Lett 8: 2849-54 (1999)


Article DOI: 10.1016/s0960-894x(98)00510-1
BindingDB Entry DOI: 10.7270/Q2Z0379C
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM50279772
PNG
(2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-cy...)
Show SMILES N[C@](CC1c2ccccc2Oc2ccccc12)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C20H19NO5/c21-20(19(24)25,15-9-13(15)18(22)23)10-14-11-5-1-3-7-16(11)26-17-8-4-2-6-12(14)17/h1-8,13-15H,9-10,21H2,(H,22,23)(H,24,25)/t13-,15-,20+/m0/s1
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n/an/a 16n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Ability to block 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in non-neuronal cell line expressing human Metabotropic glutamate r...


J Med Chem 41: 346-57 (1998)


Article DOI: 10.1021/jm970497w
BindingDB Entry DOI: 10.7270/Q22F7MJ0
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM50062522
PNG
((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)
Show SMILES N[C@@](CC1c2ccccc2Oc2ccccc12)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C20H19NO5/c21-20(19(24)25,15-9-13(15)18(22)23)10-14-11-5-1-3-7-16(11)26-17-8-4-2-6-12(14)17/h1-8,13-15H,9-10,21H2,(H,22,23)(H,24,25)/t13-,15-,20-/m0/s1
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n/an/a 16n/an/an/an/an/an/a



Universit£ di Perugia

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of binding of [3H]glutamate against rat recombinant mGluR3 receptors expressed in HEK293 cells


Bioorg Med Chem Lett 11: 3179-82 (2001)


Article DOI: 10.1016/s0960-894x(01)00656-4
BindingDB Entry DOI: 10.7270/Q27M08H1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM50333000
PNG
(4-(3-(2-methylpyridin-4-yl)phenyl)-8-(trifluoromet...)
Show SMILES Cc1cc(ccn1)-c1cccc(c1)C1=Nc2ccc(cc2NC(=O)C1)C(F)(F)F
Show InChI InChI=1S/C22H16F3N3O/c1-13-9-15(7-8-26-13)14-3-2-4-16(10-14)19-12-21(29)28-20-11-17(22(23,24)25)5-6-18(20)27-19/h2-11H,12H2,1H3,(H,28,29)
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n/an/a 17n/an/an/an/an/an/a



F. Hoffmann-La Roche Inc

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR3 receptor expressed in CHO cells assessed as inhibition of GIRK current


Bioorg Med Chem Lett 20: 6969-74 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.125
BindingDB Entry DOI: 10.7270/Q2X63N6R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM50376468
PNG
(CHEMBL259054)
Show SMILES Fc1ccc(cc1)-c1ccc2N=C(CC(=O)Nc2c1)c1cccc(c1)-n1ccnc1
Show InChI InChI=1S/C24H17FN4O/c25-19-7-4-16(5-8-19)17-6-9-21-23(13-17)28-24(30)14-22(27-21)18-2-1-3-20(12-18)29-11-10-26-15-29/h1-13,15H,14H2,(H,28,30)
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n/an/a 17n/an/an/an/an/an/a



F. Hoffmann-La Roche Inc

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR3 expressed in CHO cells assessed as inhibition of glutamate-induced GIRK current


Bioorg Med Chem Lett 18: 2725-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.076
BindingDB Entry DOI: 10.7270/Q2S75H7D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM50204267
PNG
(CHEMBL3939492)
Show SMILES COC(=O)N[C@H]1[C@H]2[C@@H]([C@H]2[C@@](N)([C@@H]1OCc1ccc(Cl)c(Cl)c1)C(O)=O)C(O)=O
Show InChI InChI=1/C17H18Cl2N2O7/c1-27-16(26)21-12-9-10(14(22)23)11(9)17(20,15(24)25)13(12)28-5-6-2-3-7(18)8(19)4-6/h2-4,9-13H,5,20H2,1H3,(H,21,26)(H,22,23)(H,24,25)/t9-,10-,11-,12-,13+,17+/s2
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n/an/a 21n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human mGlu3 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as reduction of DCG-4-inhi...


Bioorg Med Chem Lett 26: 5663-5668 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.067
BindingDB Entry DOI: 10.7270/Q2JS9SDT
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM50151435
PNG
((1R,2R,3R,5R,6R)-2-Amino-3-(3,4-dichloro-benzyloxy...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1ccc(Cl)c(Cl)c1)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H14Cl2FNO5/c16-8-2-1-6(3-9(8)17)5-24-10-4-7-11(14(7,18)12(20)21)15(10,19)13(22)23/h1-3,7,10-11H,4-5,19H2,(H,20,21)(H,22,23)/t7-,10-,11+,14-,15+/m1/s1
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n/an/a 24n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Concentration required to inhibit metabotropic glutamate receptor 3 activity of rat expressed in CHO cells


J Med Chem 47: 4570-87 (2004)


Article DOI: 10.1021/jm0400294
BindingDB Entry DOI: 10.7270/Q2GH9HFK
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM50204261
PNG
(CHEMBL3969063)
Show SMILES N[C@@]1([C@H]2[C@H]([C@@H]2C(O)=O)[C@H](Sc2nc[nH]n2)[C@H]1OCc1ccc(Cl)c(Cl)c1)C(O)=O
Show InChI InChI=1/C17H16Cl2N4O5S/c18-7-2-1-6(3-8(7)19)4-28-13-12(29-16-21-5-22-23-16)9-10(14(24)25)11(9)17(13,20)15(26)27/h1-3,5,9-13H,4,20H2,(H,24,25)(H,26,27)(H,21,22,23)/t9-,10-,11-,12-,13+,17+/s2
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n/an/a 24n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human mGlu3 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as reduction of DCG-4-inhi...


Bioorg Med Chem Lett 26: 5663-5668 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.067
BindingDB Entry DOI: 10.7270/Q2JS9SDT
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM50151435
PNG
((1R,2R,3R,5R,6R)-2-Amino-3-(3,4-dichloro-benzyloxy...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1ccc(Cl)c(Cl)c1)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H14Cl2FNO5/c16-8-2-1-6(3-9(8)17)5-24-10-4-7-11(14(7,18)12(20)21)15(10,19)13(22)23/h1-3,7,10-11H,4-5,19H2,(H,20,21)(H,22,23)/t7-,10-,11+,14-,15+/m1/s1
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n/an/a 24n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Antagonist activity at mGLUR3 expressed in CHO cells assessed as inhibition of glutamate-induced inhibition of forskolin-stimulated cAMP production


Bioorg Med Chem Lett 22: 1958-62 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.039
BindingDB Entry DOI: 10.7270/Q2T72JJ1
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM50332989
PNG
(4-(3-(pyridin-4-yl)phenyl)-8-(trifluoromethyl)-1H-...)
Show SMILES FC(F)(F)c1ccc2N=C(CC(=O)Nc2c1)c1cccc(c1)-c1ccncc1
Show InChI InChI=1S/C21H14F3N3O/c22-21(23,24)16-4-5-17-19(11-16)27-20(28)12-18(26-17)15-3-1-2-14(10-15)13-6-8-25-9-7-13/h1-11H,12H2,(H,27,28)
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n/an/a 29n/an/an/an/an/an/a



F. Hoffmann-La Roche Inc

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR3 receptor expressed in CHO cells assessed as inhibition of GIRK current


Bioorg Med Chem Lett 20: 6969-74 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.125
BindingDB Entry DOI: 10.7270/Q2X63N6R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM50072177
PNG
((1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl...)
Show SMILES CCCC[C@@H]1[C@@H]([C@H]1C(N)(CC1c2ccccc2Oc2ccccc12)C(O)=O)C(O)=O
Show InChI InChI=1S/C24H27NO5/c1-2-3-8-16-20(22(26)27)21(16)24(25,23(28)29)13-17-14-9-4-6-11-18(14)30-19-12-7-5-10-15(17)19/h4-7,9-12,16-17,20-21H,2-3,8,13,25H2,1H3,(H,26,27)(H,28,29)/t16-,20+,21+,24?/m1/s1
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n/an/a 29n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonistic activity against metabotropic glutamate receptor 3 (mGluR3) was evaluated


Bioorg Med Chem Lett 8: 2849-54 (1999)


Article DOI: 10.1016/s0960-894x(98)00510-1
BindingDB Entry DOI: 10.7270/Q2Z0379C
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM50332966
PNG
(7,8-dichloro-4-(3-(2-methylpyridin-4-yl)phenyl)-1H...)
Show SMILES Cc1cc(ccn1)-c1cccc(c1)C1=Nc2cc(Cl)c(Cl)cc2NC(=O)C1
Show InChI InChI=1S/C21H15Cl2N3O/c1-12-7-14(5-6-24-12)13-3-2-4-15(8-13)18-11-21(27)26-20-10-17(23)16(22)9-19(20)25-18/h2-10H,11H2,1H3,(H,26,27)
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n/an/a 30n/an/an/an/an/an/a



F. Hoffmann-La Roche Inc

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR3 receptor expressed in CHO cells assessed as inhibition of GIRK current


Bioorg Med Chem Lett 20: 6969-74 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.125
BindingDB Entry DOI: 10.7270/Q2X63N6R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM50204256
PNG
(CHEMBL3948272)
Show SMILES Cn1ncnc1S[C@H]1[C@H]2[C@@H]([C@H]2[C@@](N)([C@@H]1OCc1ccc(Cl)c(Cl)c1)C(O)=O)C(O)=O
Show InChI InChI=1/C18H18Cl2N4O5S/c1-24-17(22-6-23-24)30-13-10-11(15(25)26)12(10)18(21,16(27)28)14(13)29-5-7-2-3-8(19)9(20)4-7/h2-4,6,10-14H,5,21H2,1H3,(H,25,26)(H,27,28)/t10-,11-,12-,13-,14+,18+/s2
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n/an/a 30n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human mGlu3 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as reduction of DCG-4-inhi...


Bioorg Med Chem Lett 26: 5663-5668 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.067
BindingDB Entry DOI: 10.7270/Q2JS9SDT
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM50332991
PNG
(4-(3-(1H-1,2,3-triazol-1-yl)phenyl)-8-(2-fluorophe...)
Show SMILES Fc1ccccc1-c1ccc2N=C(CC(=O)Nc2c1)c1cccc(c1)-n1ccnn1
Show InChI InChI=1S/C23H16FN5O/c24-19-7-2-1-6-18(19)15-8-9-20-22(13-15)27-23(30)14-21(26-20)16-4-3-5-17(12-16)29-11-10-25-28-29/h1-13H,14H2,(H,27,30)
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n/an/a 33n/an/an/an/an/an/a



F. Hoffmann-La Roche Inc

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR3 receptor expressed in CHO cells assessed as inhibition of GIRK current


Bioorg Med Chem Lett 20: 6969-74 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.125
BindingDB Entry DOI: 10.7270/Q2X63N6R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM50376467
PNG
(CHEMBL260636)
Show SMILES Fc1ccccc1-c1ccc2N=C(CC(=O)Nc2c1)c1cccc(c1)-n1ccnc1
Show InChI InChI=1S/C24H17FN4O/c25-20-7-2-1-6-19(20)16-8-9-21-23(13-16)28-24(30)14-22(27-21)17-4-3-5-18(12-17)29-11-10-26-15-29/h1-13,15H,14H2,(H,28,30)
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n/an/a 33n/an/an/an/an/an/a



F. Hoffmann-La Roche Inc

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR3 expressed in CHO cells assessed as inhibition of glutamate-induced GIRK current


Bioorg Med Chem Lett 18: 2725-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.076
BindingDB Entry DOI: 10.7270/Q2S75H7D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM50204268
PNG
(CHEMBL3977508)
Show SMILES N[C@@]1([C@H]2[C@H]([C@@H]2C(O)=O)[C@H](Sc2ncc[nH]2)[C@H]1OCc1ccc(Cl)c(Cl)c1)C(O)=O
Show InChI InChI=1/C18H17Cl2N3O5S/c19-8-2-1-7(5-9(8)20)6-28-14-13(29-17-22-3-4-23-17)10-11(15(24)25)12(10)18(14,21)16(26)27/h1-5,10-14H,6,21H2,(H,22,23)(H,24,25)(H,26,27)/t10-,11-,12-,13-,14+,18+/s2
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n/an/a 39n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human mGlu3 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as reduction of DCG-4-inhi...


Bioorg Med Chem Lett 26: 5663-5668 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.067
BindingDB Entry DOI: 10.7270/Q2JS9SDT
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM50072170
PNG
((1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl...)
Show SMILES CC(C)C[C@@H]1[C@@H]([C@H]1C(N)(CC1c2ccccc2Oc2ccccc12)C(O)=O)C(O)=O
Show InChI InChI=1S/C24H27NO5/c1-13(2)11-16-20(22(26)27)21(16)24(25,23(28)29)12-17-14-7-3-5-9-18(14)30-19-10-6-4-8-15(17)19/h3-10,13,16-17,20-21H,11-12,25H2,1-2H3,(H,26,27)(H,28,29)/t16-,20+,21+,24?/m1/s1
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n/an/a 40n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonistic activity against metabotropic glutamate receptor 3 (mGluR3) was evaluated


Bioorg Med Chem Lett 8: 2849-54 (1999)


Article DOI: 10.1016/s0960-894x(98)00510-1
BindingDB Entry DOI: 10.7270/Q2Z0379C
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM50332991
PNG
(4-(3-(1H-1,2,3-triazol-1-yl)phenyl)-8-(2-fluorophe...)
Show SMILES Fc1ccccc1-c1ccc2N=C(CC(=O)Nc2c1)c1cccc(c1)-n1ccnn1
Show InChI InChI=1S/C23H16FN5O/c24-19-7-2-1-6-18(19)15-8-9-20-22(13-15)27-23(30)14-21(26-20)16-4-3-5-17(12-16)29-11-10-25-28-29/h1-13H,14H2,(H,27,30)
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n/an/a 42n/an/an/an/an/an/a



F. Hoffmann-La Roche Inc

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR3 expressed in CHO cells assessed as inhibition of glutamate-induced GIRK current


Bioorg Med Chem Lett 18: 2725-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.076
BindingDB Entry DOI: 10.7270/Q2S75H7D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM50204257
PNG
(CHEMBL3947221)
Show SMILES N[C@@]1([C@H]2[C@H]([C@@H]2C(O)=O)[C@H](O)[C@H]1OCc1ccc(Cl)c(Cl)c1)C(O)=O
Show InChI InChI=1/C15H15Cl2NO6/c16-6-2-1-5(3-7(6)17)4-24-12-11(19)8-9(13(20)21)10(8)15(12,18)14(22)23/h1-3,8-12,19H,4,18H2,(H,20,21)(H,22,23)/t8-,9-,10-,11-,12+,15+/s2
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n/an/a 46n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human mGlu3 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as reduction of DCG-4-inhi...


Bioorg Med Chem Lett 26: 5663-5668 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.067
BindingDB Entry DOI: 10.7270/Q2JS9SDT
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM50204258
PNG
(CHEMBL3933829)
Show SMILES N[C@@]1([C@H]2[C@H]([C@@H]2C(O)=O)[C@H](N=[N+]=[N-])[C@H]1OCc1ccc(Cl)c(Cl)c1)C(O)=O
Show InChI InChI=1/C15H14Cl2N4O5/c16-6-2-1-5(3-7(6)17)4-26-12-11(20-21-19)8-9(13(22)23)10(8)15(12,18)14(24)25/h1-3,8-12H,4,18H2,(H,22,23)(H,24,25)/t8-,9-,10-,11-,12+,15+/s2
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n/an/a 54n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human mGlu3 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as reduction of DCG-4-inhi...


Bioorg Med Chem Lett 26: 5663-5668 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.067
BindingDB Entry DOI: 10.7270/Q2JS9SDT
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM50017610
PNG
(CHEMBL3288662)
Show SMILES Cn1c2cc(nn2c2cc(ccc2c1=O)-c1cccnc1)-c1ccc(F)cc1
Show InChI InChI=1S/C22H15FN4O/c1-26-21-12-19(14-4-7-17(23)8-5-14)25-27(21)20-11-15(6-9-18(20)22(26)28)16-3-2-10-24-13-16/h2-13H,1H3
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n/an/a 67n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of rat mGlu3 receptor transfected in HEK293 cells coexpressing mouse Galpha15 assessed as decrease in glutamate-induced calcium signaling ...


Bioorg Med Chem Lett 24: 2693-8 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.051
BindingDB Entry DOI: 10.7270/Q228094H
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM50204266
PNG
(CHEMBL3961306)
Show SMILES N[C@@]1([C@H]2[C@H]([C@@H]2C(O)=O)[C@H](F)[C@H]1OCc1ccc(Cl)c(Cl)c1)C(O)=O
Show InChI InChI=1/C15H14Cl2FNO5/c16-6-2-1-5(3-7(6)17)4-24-12-11(18)8-9(13(20)21)10(8)15(12,19)14(22)23/h1-3,8-12H,4,19H2,(H,20,21)(H,22,23)/t8-,9-,10-,11-,12+,15+/s2
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n/an/a 71n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human mGlu3 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as reduction of DCG-4-inhi...


Bioorg Med Chem Lett 26: 5663-5668 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.067
BindingDB Entry DOI: 10.7270/Q2JS9SDT
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM50107108
PNG
((1S,2S,3R)-2-(Amino-carboxy-methyl)-3-[2-(9H-xanth...)
Show SMILES NC([C@H]1[C@@H](CCC2c3ccccc3Oc3ccccc23)[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C21H21NO5/c22-19(21(25)26)17-14(18(17)20(23)24)10-9-11-12-5-1-3-7-15(12)27-16-8-4-2-6-13(11)16/h1-8,11,14,17-19H,9-10,22H2,(H,23,24)(H,25,26)/t14-,17+,18+,19?/m1/s1
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n/an/a 75n/an/an/an/an/an/a



Universit£ di Perugia

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of binding of [3H]glutamate against rat recombinant Metabotropic glutamate receptor 3 expressed in HEK293 c...


Bioorg Med Chem Lett 11: 3179-82 (2001)


Article DOI: 10.1016/s0960-894x(01)00656-4
BindingDB Entry DOI: 10.7270/Q27M08H1
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM50072172
PNG
((1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl...)
Show SMILES CC[C@@H]1[C@@H]([C@H]1C(N)(CC1c2ccccc2Oc2ccccc12)C(O)=O)C(O)=O
Show InChI InChI=1S/C22H23NO5/c1-2-12-18(20(24)25)19(12)22(23,21(26)27)11-15-13-7-3-5-9-16(13)28-17-10-6-4-8-14(15)17/h3-10,12,15,18-19H,2,11,23H2,1H3,(H,24,25)(H,26,27)/t12-,18+,19+,22?/m1/s1
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n/an/a 76n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonistic activity against metabotropic glutamate receptor 3 (mGluR3) was evaluated


Bioorg Med Chem Lett 8: 2849-54 (1999)


Article DOI: 10.1016/s0960-894x(98)00510-1
BindingDB Entry DOI: 10.7270/Q2Z0379C
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM50204253
PNG
(CHEMBL3956934)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1Cc1ccc(F)c(Cl)c1)[C@@H]2C(O)=O)C(O)=O
Show InChI InChI=1/C15H15ClFNO4/c16-9-4-6(1-2-10(9)17)3-7-5-8-11(13(19)20)12(8)15(7,18)14(21)22/h1-2,4,7-8,11-12H,3,5,18H2,(H,19,20)(H,21,22)/t7-,8+,11+,12+,15+/s2
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n/an/a 76n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human mGlu3 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as reduction of DCG-4-inhi...


Bioorg Med Chem Lett 26: 5663-5668 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.067
BindingDB Entry DOI: 10.7270/Q2JS9SDT
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM50017663
PNG
(CHEMBL3288676)
Show SMILES Cn1c2cc(nn2c2cc(ccc2c1=O)-c1cncnc1)-c1ccccc1
Show InChI InChI=1S/C21H15N5O/c1-25-20-10-18(14-5-3-2-4-6-14)24-26(20)19-9-15(7-8-17(19)21(25)27)16-11-22-13-23-12-16/h2-13H,1H3
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n/an/a 78n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of rat mGlu3 receptor transfected in HEK293 cells coexpressing mouse Galpha15 assessed as decrease in glutamate-induced calcium signaling ...


Bioorg Med Chem Lett 24: 2693-8 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.051
BindingDB Entry DOI: 10.7270/Q228094H
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM50017663
PNG
(CHEMBL3288676)
Show SMILES Cn1c2cc(nn2c2cc(ccc2c1=O)-c1cncnc1)-c1ccccc1
Show InChI InChI=1S/C21H15N5O/c1-25-20-10-18(14-5-3-2-4-6-14)24-26(20)19-9-15(7-8-17(19)21(25)27)16-11-22-13-23-12-16/h2-13H,1H3
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n/an/a 78n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of rat mGlu3 receptor transfected in HEK293 cells coexpressing mouse Galpha15 assessed as decrease in glutamate-induced calcium signaling ...


Bioorg Med Chem Lett 24: 2693-8 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.051
BindingDB Entry DOI: 10.7270/Q228094H
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM50062520
PNG
((1S,2S)-2-((R)-1-Amino-1-carboxy-3-m-tolyl-propyl)...)
Show SMILES Cc1cccc(CC[C@@](N)([C@H]2C[C@@H]2C(O)=O)C(O)=O)c1
Show InChI InChI=1S/C15H19NO4/c1-9-3-2-4-10(7-9)5-6-15(16,14(19)20)12-8-11(12)13(17)18/h2-4,7,11-12H,5-6,8,16H2,1H3,(H,17,18)(H,19,20)/t11-,12-,15+/m0/s1
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n/an/a 80n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3


J Med Chem 41: 358-78 (1998)


Article DOI: 10.1021/jm970498o
BindingDB Entry DOI: 10.7270/Q2XP7423
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM50408697
PNG
(CHEMBL2112634)
Show SMILES NC(CCc1cccc(c1)C(O)=O)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C15H17NO6/c16-15(14(21)22,11-7-10(11)13(19)20)5-4-8-2-1-3-9(6-8)12(17)18/h1-3,6,10-11H,4-5,7,16H2,(H,17,18)(H,19,20)(H,21,22)/t10-,11-,15?/m0/s1
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n/an/a 80n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3


J Med Chem 41: 358-78 (1998)


Article DOI: 10.1021/jm970498o
BindingDB Entry DOI: 10.7270/Q2XP7423
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM50204270
PNG
(CHEMBL3918170)
Show SMILES N[C@@]1([C@H]2[C@H]([C@@H]2C(O)=O)[C@@H](O)[C@H]1OCc1cccc(Cl)c1Cl)C(O)=O
Show InChI InChI=1/C15H15Cl2NO6/c16-6-3-1-2-5(10(6)17)4-24-12-11(19)7-8(13(20)21)9(7)15(12,18)14(22)23/h1-3,7-9,11-12,19H,4,18H2,(H,20,21)(H,22,23)/t7-,8-,9-,11+,12+,15+/s2
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n/an/a 83n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human mGlu3 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as reduction of DCG-4-inhi...


Bioorg Med Chem Lett 26: 5663-5668 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.067
BindingDB Entry DOI: 10.7270/Q2JS9SDT
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM50204255
PNG
(CHEMBL3927108)
Show SMILES Cc1cc(CO[C@@H]2[C@H](O)[C@H]3[C@@H]([C@H]3[C@]2(N)C(O)=O)C(O)=O)ccc1F
Show InChI InChI=1/C16H18FNO6/c1-6-4-7(2-3-8(6)17)5-24-13-12(19)9-10(14(20)21)11(9)16(13,18)15(22)23/h2-4,9-13,19H,5,18H2,1H3,(H,20,21)(H,22,23)/t9-,10-,11-,12+,13+,16+/s2
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n/an/a 85n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human mGlu3 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as reduction of DCG-4-inhi...


Bioorg Med Chem Lett 26: 5663-5668 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.067
BindingDB Entry DOI: 10.7270/Q2JS9SDT
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM50121652
PNG
(CHEMBL3616851)
Show SMILES Nc1nnc(S[C@@H]2C[C@](N)([C@H]3[C@@H]2[C@@H]3C(O)=O)C(O)=O)[nH]1
Show InChI InChI=1/C10H13N5O4S/c11-8-13-9(15-14-8)20-2-1-10(12,7(18)19)5-3(2)4(5)6(16)17/h2-5H,1,12H2,(H,16,17)(H,18,19)(H3,11,13,14,15)/t2-,3+,4+,5+,10+/s2
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n/an/a 95n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant mGlu3 receptor expressed in AV12 cells assessed as inhibition of glutamate-stimulated Ca2+ mobilization afte...


J Med Chem 58: 7526-48 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01124
BindingDB Entry DOI: 10.7270/Q29S1ST0
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM50072169
PNG
((1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl...)
Show SMILES CCCCC[C@@H]1[C@@H]([C@H]1C(N)(CC1c2ccccc2Oc2ccccc12)C(O)=O)C(O)=O
Show InChI InChI=1S/C25H29NO5/c1-2-3-4-11-17-21(23(27)28)22(17)25(26,24(29)30)14-18-15-9-5-7-12-19(15)31-20-13-8-6-10-16(18)20/h5-10,12-13,17-18,21-22H,2-4,11,14,26H2,1H3,(H,27,28)(H,29,30)/t17-,21+,22+,25?/m1/s1
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n/an/a 100n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonistic activity against metabotropic glutamate receptor 3 (mGluR3) was evaluated


Bioorg Med Chem Lett 8: 2849-54 (1999)


Article DOI: 10.1016/s0960-894x(98)00510-1
BindingDB Entry DOI: 10.7270/Q2Z0379C
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM50072173
PNG
((1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl...)
Show SMILES CCCCCC[C@@H]1[C@@H]([C@H]1C(N)(CC1c2ccccc2Oc2ccccc12)C(O)=O)C(O)=O
Show InChI InChI=1S/C26H31NO5/c1-2-3-4-5-12-18-22(24(28)29)23(18)26(27,25(30)31)15-19-16-10-6-8-13-20(16)32-21-14-9-7-11-17(19)21/h6-11,13-14,18-19,22-23H,2-5,12,15,27H2,1H3,(H,28,29)(H,30,31)/t18-,22+,23+,26?/m1/s1
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n/an/a 122n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonistic activity against metabotropic glutamate receptor 3 (mGluR3) was evaluated


Bioorg Med Chem Lett 8: 2849-54 (1999)


Article DOI: 10.1016/s0960-894x(98)00510-1
BindingDB Entry DOI: 10.7270/Q2Z0379C
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM50376470
PNG
(CHEMBL405895)
Show SMILES Oc1cc2N=C(CC(=O)Nc2cc1-c1ccccc1F)c1cccc(c1)-n1ccnc1
Show InChI InChI=1S/C24H17FN4O2/c25-19-7-2-1-6-17(19)18-11-21-22(12-23(18)30)27-20(13-24(31)28-21)15-4-3-5-16(10-15)29-9-8-26-14-29/h1-12,14,30H,13H2,(H,28,31)
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n/an/a 122n/an/an/an/an/an/a



F. Hoffmann-La Roche Inc

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR3 expressed in CHO cells assessed as inhibition of glutamate-induced GIRK current


Bioorg Med Chem Lett 18: 2725-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.076
BindingDB Entry DOI: 10.7270/Q2S75H7D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM50122268
PNG
(CHEMBL3617624)
Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccc(F)cn3)nn12)c1cc(F)ccc1F
Show InChI InChI=1/C19H15F3N4O2/c1-11-9-25(16-6-12(20)2-4-15(16)22)19(27)17-7-14(24-26(11)17)10-28-18-5-3-13(21)8-23-18/h2-8,11H,9-10H2,1H3/t11-/s2
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n/an/a 123n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01005
BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM50122268
PNG
(CHEMBL3617624)
Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccc(F)cn3)nn12)c1cc(F)ccc1F
Show InChI InChI=1/C19H15F3N4O2/c1-11-9-25(16-6-12(20)2-4-15(16)22)19(27)17-7-14(24-26(11)17)10-28-18-5-3-13(21)8-23-18/h2-8,11H,9-10H2,1H3/t11-/s2
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n/an/a 123n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01005
BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM50072176
PNG
((1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl...)
Show SMILES NC(CC1c2ccccc2Oc2ccccc12)([C@H]1[C@H](CCc2ccccc2)[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C28H27NO5/c29-28(27(32)33,25-20(24(25)26(30)31)15-14-17-8-2-1-3-9-17)16-21-18-10-4-6-12-22(18)34-23-13-7-5-11-19(21)23/h1-13,20-21,24-25H,14-16,29H2,(H,30,31)(H,32,33)/t20-,24+,25+,28?/m1/s1
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n/an/a 125n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonistic activity against metabotropic glutamate receptor 3 (mGluR3) was evaluated


Bioorg Med Chem Lett 8: 2849-54 (1999)


Article DOI: 10.1016/s0960-894x(98)00510-1
BindingDB Entry DOI: 10.7270/Q2Z0379C
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM50204264
PNG
(CHEMBL3890112)
Show SMILES N[C@@]1([C@H]2[C@H]([C@@H]2C(O)=O)[C@@H](O)[C@H]1OCc1ccc(Cl)c(F)c1)C(O)=O
Show InChI InChI=1/C15H15ClFNO6/c16-6-2-1-5(3-7(6)17)4-24-12-11(19)8-9(13(20)21)10(8)15(12,18)14(22)23/h1-3,8-12,19H,4,18H2,(H,20,21)(H,22,23)/t8-,9-,10-,11+,12+,15+/s2
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n/an/a 127n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human mGlu3 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as reduction of DCG-4-inhi...


Bioorg Med Chem Lett 26: 5663-5668 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.067
BindingDB Entry DOI: 10.7270/Q2JS9SDT
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM50122278
PNG
(CHEMBL3617614)
Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccc(F)cn3)nn12)c1ccccc1Cl
Show InChI InChI=1/C19H16ClFN4O2/c1-12-10-24(16-5-3-2-4-15(16)20)19(26)17-8-14(23-25(12)17)11-27-18-7-6-13(21)9-22-18/h2-9,12H,10-11H2,1H3/t12-/s2
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n/an/a 141n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01005
BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM50122278
PNG
(CHEMBL3617614)
Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccc(F)cn3)nn12)c1ccccc1Cl
Show InChI InChI=1/C19H16ClFN4O2/c1-12-10-24(16-5-3-2-4-15(16)20)19(26)17-8-14(23-25(12)17)11-27-18-7-6-13(21)9-22-18/h2-9,12H,10-11H2,1H3/t12-/s2
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n/an/a 141n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01005
BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM50122277
PNG
(CHEMBL3617615)
Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccc(F)cn3)nn12)c1cccc(Cl)c1
Show InChI InChI=1/C19H16ClFN4O2/c1-12-10-24(16-4-2-3-13(20)7-16)19(26)17-8-15(23-25(12)17)11-27-18-6-5-14(21)9-22-18/h2-9,12H,10-11H2,1H3/t12-/s2
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n/an/a 145n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01005
BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Rattus norvegicus (Rat))
BDBM50122277
PNG
(CHEMBL3617615)
Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccc(F)cn3)nn12)c1cccc(Cl)c1
Show InChI InChI=1/C19H16ClFN4O2/c1-12-10-24(16-4-2-3-13(20)7-16)19(26)17-8-15(23-25(12)17)11-27-18-6-5-14(21)9-22-18/h2-9,12H,10-11H2,1H3/t12-/s2
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n/an/a 145n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay


J Med Chem 58: 7485-500 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01005
BindingDB Entry DOI: 10.7270/Q2H9970P
More data for this
Ligand-Target Pair
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