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Compile Data Set for Download or QSAR

Found 294 hits Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 3'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
metabotropic glutamate 1c


(HUMAN)
BDBM50062522
PNG
((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)
Show SMILES N[C@@](CC1c2ccccc2Oc2ccccc12)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C20H19NO5/c21-20(19(24)25,15-9-13(15)18(22)23)10-14-11-5-1-3-7-16(11)26-17-8-4-2-6-12(14)17/h1-8,13-15H,9-10,21H2,(H,22,23)(H,24,25)/t13-,15-,20-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3


J Med Chem 41: 358-78 (1998)

More data for this
Ligand-Target Pair
metabotropic glutamate 1c


(HUMAN)
BDBM50062522
PNG
((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)
Show SMILES N[C@@](CC1c2ccccc2Oc2ccccc12)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C20H19NO5/c21-20(19(24)25,15-9-13(15)18(22)23)10-14-11-5-1-3-7-16(11)26-17-8-4-2-6-12(14)17/h1-8,13-15H,9-10,21H2,(H,22,23)(H,24,25)/t13-,15-,20-/m0/s1
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n/an/a 14n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Antagonist activity at human mGLUR3 expressed in RGT cells assessed as inhibition of (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid-induced inhibi...


Bioorg Med Chem Lett 22: 1958-62 (2012)

More data for this
Ligand-Target Pair
metabotropic glutamate 1c


(HUMAN)
BDBM50279772
PNG
(2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-cy...)
Show SMILES N[C@](CC1c2ccccc2Oc2ccccc12)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C20H19NO5/c21-20(19(24)25,15-9-13(15)18(22)23)10-14-11-5-1-3-7-16(11)26-17-8-4-2-6-12(14)17/h1-8,13-15H,9-10,21H2,(H,22,23)(H,24,25)/t13-,15-,20+/m0/s1
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n/an/a 16n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Ability to block 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in non-neuronal cell line expressing human Metabotropic glutamate r...


J Med Chem 41: 346-57 (1998)

More data for this
Ligand-Target Pair
metabotropic glutamate 1c


(HUMAN)
BDBM50151435
PNG
((1R,2R,3R,5R,6R)-2-Amino-3-(3,4-dichloro-benzyloxy...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1ccc(Cl)c(Cl)c1)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H14Cl2FNO5/c16-8-2-1-6(3-9(8)17)5-24-10-4-7-11(14(7,18)12(20)21)15(10,19)13(22)23/h1-3,7,10-11H,4-5,19H2,(H,20,21)(H,22,23)/t7-,10-,11+,14-,15+/m1/s1
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n/an/a 24n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Antagonist activity at mGLUR3 expressed in CHO cells assessed as inhibition of glutamate-induced inhibition of forskolin-stimulated cAMP production


Bioorg Med Chem Lett 22: 1958-62 (2012)

More data for this
Ligand-Target Pair
metabotropic glutamate 1c


(HUMAN)
BDBM50062520
PNG
((1S,2S)-2-((R)-1-Amino-1-carboxy-3-m-tolyl-propyl)...)
Show SMILES Cc1cccc(CC[C@@](N)([C@H]2C[C@@H]2C(O)=O)C(O)=O)c1
Show InChI InChI=1S/C15H19NO4/c1-9-3-2-4-10(7-9)5-6-15(16,14(19)20)12-8-11(12)13(17)18/h2-4,7,11-12H,5-6,8,16H2,1H3,(H,17,18)(H,19,20)/t11-,12-,15+/m0/s1
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3


J Med Chem 41: 358-78 (1998)

More data for this
Ligand-Target Pair
metabotropic glutamate 1c


(HUMAN)
BDBM50408697
PNG
(CHEMBL2112634)
Show SMILES NC(CCc1cccc(c1)C(O)=O)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C15H17NO6/c16-15(14(21)22,11-7-10(11)13(19)20)5-4-8-2-1-3-9(6-8)12(17)18/h1-3,6,10-11H,4-5,7,16H2,(H,17,18)(H,19,20)(H,21,22)/t10-,11-,15?/m0/s1
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3


J Med Chem 41: 358-78 (1998)

More data for this
Ligand-Target Pair
metabotropic glutamate 1c


(HUMAN)
BDBM50121652
PNG
(CHEMBL3616851)
Show SMILES Nc1nnc(S[C@@H]2C[C@](N)([C@H]3[C@@H]2[C@@H]3C(O)=O)C(O)=O)[nH]1
Show InChI InChI=1/C10H13N5O4S/c11-8-13-9(15-14-8)20-2-1-10(12,7(18)19)5-3(2)4(5)6(16)17/h2-5H,1,12H2,(H,16,17)(H,18,19)(H3,11,13,14,15)/t2-,3+,4+,5+,10+/s2
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n/an/a 95n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant mGlu3 receptor expressed in AV12 cells assessed as inhibition of glutamate-stimulated Ca2+ mobilization afte...


J Med Chem 58: 7526-48 (2015)

More data for this
Ligand-Target Pair
metabotropic glutamate 1c


(HUMAN)
BDBM50121651
PNG
(CHEMBL3616850)
Show SMILES N[C@]1(C[C@@H](Sc2nnc([nH]2)C(F)F)[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Show InChI InChI=1/C11H12F2N4O4S/c12-6(13)7-15-10(17-16-7)22-2-1-11(14,9(20)21)5-3(2)4(5)8(18)19/h2-6H,1,14H2,(H,18,19)(H,20,21)(H,15,16,17)/t2-,3+,4+,5+,11+/s2
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Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant mGlu3 receptor expressed in AV12 cells assessed as inhibition of glutamate-stimulated Ca2+ mobilization afte...


J Med Chem 58: 7526-48 (2015)

More data for this
Ligand-Target Pair
metabotropic glutamate 1c


(HUMAN)
BDBM50062534
PNG
((S)-2-[(R)-1-Amino-1-carboxy-3-(3-methoxy-phenyl)-...)
Show SMILES COc1cccc(CC[C@@](N)(C2C[C@@H]2C(O)=O)C(O)=O)c1
Show InChI InChI=1S/C15H19NO5/c1-21-10-4-2-3-9(7-10)5-6-15(16,14(19)20)12-8-11(12)13(17)18/h2-4,7,11-12H,5-6,8,16H2,1H3,(H,17,18)(H,19,20)/t11-,12?,15+/m0/s1
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3


J Med Chem 41: 358-78 (1998)

More data for this
Ligand-Target Pair
metabotropic glutamate 1c


(HUMAN)
BDBM50062543
PNG
((1S,2S)-2-((S)-1-Amino-1-carboxy-3,3-diphenyl-prop...)
Show SMILES N[C@@](CC(c1ccccc1)c1ccccc1)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C20H21NO4/c21-20(19(24)25,17-11-15(17)18(22)23)12-16(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10,15-17H,11-12,21H2,(H,22,23)(H,24,25)/t15-,17-,20-/m0/s1
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3


J Med Chem 41: 358-78 (1998)

More data for this
Ligand-Target Pair
metabotropic glutamate 1c


(HUMAN)
BDBM50062518
PNG
((S)-2-[(R)-1-Amino-1-carboxy-3-(3-chloro-phenyl)-p...)
Show SMILES N[C@](CCc1cccc(Cl)c1)(C1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C14H16ClNO4/c15-9-3-1-2-8(6-9)4-5-14(16,13(19)20)11-7-10(11)12(17)18/h1-3,6,10-11H,4-5,7,16H2,(H,17,18)(H,19,20)/t10-,11?,14+/m0/s1
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3


J Med Chem 41: 358-78 (1998)

More data for this
Ligand-Target Pair
metabotropic glutamate 1c


(HUMAN)
BDBM50408696
PNG
(CHEMBL2111822)
Show SMILES CS(=O)(=O)c1cccc(CC[C@@](N)(C2C[C@@H]2C(O)=O)C(O)=O)c1
Show InChI InChI=1S/C15H19NO6S/c1-23(21,22)10-4-2-3-9(7-10)5-6-15(16,14(19)20)12-8-11(12)13(17)18/h2-4,7,11-12H,5-6,8,16H2,1H3,(H,17,18)(H,19,20)/t11-,12?,15+/m0/s1
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3


J Med Chem 41: 358-78 (1998)

More data for this
Ligand-Target Pair
metabotropic glutamate 1c


(HUMAN)
BDBM50401091
PNG
(CHEMBL2204436 | CHEMBL2385894)
Show SMILES Clc1ccc(CN[C@H]2CCN(C2)c2ncc(Br)cn2)c(Cl)c1
Show InChI InChI=1S/C15H15BrCl2N4/c16-11-7-20-15(21-8-11)22-4-3-13(9-22)19-6-10-1-2-12(17)5-14(10)18/h1-2,5,7-8,13,19H,3-4,6,9H2/t13-/m0/s1
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n/an/a 190n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGlu3 expressed in AV-12 cells in presence of glutamate EC90 concentration by FLIPR assay


Bioorg Med Chem Lett 22: 3921-5 (2012)

More data for this
Ligand-Target Pair
metabotropic glutamate 1c


(HUMAN)
BDBM50062539
PNG
((S)-2-[(R)-1-Amino-3-(3-amino-phenyl)-1-carboxy-pr...)
Show SMILES Nc1cccc(CC[C@@](N)(C2C[C@@H]2C(O)=O)C(O)=O)c1
Show InChI InChI=1S/C14H18N2O4/c15-9-3-1-2-8(6-9)4-5-14(16,13(19)20)11-7-10(11)12(17)18/h1-3,6,10-11H,4-5,7,15-16H2,(H,17,18)(H,19,20)/t10-,11?,14+/m0/s1
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3


J Med Chem 41: 358-78 (1998)

More data for this
Ligand-Target Pair
metabotropic glutamate 1c


(HUMAN)
BDBM50062526
PNG
((S)-2-[(R)-1-Amino-1-carboxy-3-(4-fluoro-phenyl)-p...)
Show SMILES N[C@](CCc1ccc(F)cc1)(C1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C14H16FNO4/c15-9-3-1-8(2-4-9)5-6-14(16,13(19)20)11-7-10(11)12(17)18/h1-4,10-11H,5-7,16H2,(H,17,18)(H,19,20)/t10-,11?,14+/m0/s1
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3


J Med Chem 41: 358-78 (1998)

More data for this
Ligand-Target Pair
metabotropic glutamate 1c


(HUMAN)
BDBM50121540
PNG
(CHEMBL3616857)
Show SMILES N[C@]1(C[C@H](Sc2nnc([nH]2)C(F)F)[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Show InChI InChI=1/C11H12F2N4O4S/c12-6(13)7-15-10(17-16-7)22-2-1-11(14,9(20)21)5-3(2)4(5)8(18)19/h2-6H,1,14H2,(H,18,19)(H,20,21)(H,15,16,17)/t2-,3-,4-,5-,11-/s2
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Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant mGlu3 receptor expressed in AV12 cells assessed as inhibition of glutamate-stimulated Ca2+ mobilization afte...


J Med Chem 58: 7526-48 (2015)

More data for this
Ligand-Target Pair
metabotropic glutamate 1c


(HUMAN)
BDBM50062529
PNG
((S)-2-[(R)-1-Amino-1-carboxy-3-(3-hydroxy-phenyl)-...)
Show SMILES N[C@](CCc1cccc(O)c1)(C1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C14H17NO5/c15-14(13(19)20,11-7-10(11)12(17)18)5-4-8-2-1-3-9(16)6-8/h1-3,6,10-11,16H,4-5,7,15H2,(H,17,18)(H,19,20)/t10-,11?,14+/m0/s1
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3


J Med Chem 41: 358-78 (1998)

More data for this
Ligand-Target Pair
metabotropic glutamate 1c


(HUMAN)
BDBM50332963
PNG
(4-(3-(2,6-dimethylpyridin-4-yl)phenyl)-7-methyl-8-...)
Show SMILES Cc1cc(cc(C)n1)-c1cccc(c1)C1=Nc2cc(C)c(cc2NC(=O)C1)C(F)(F)F
Show InChI InChI=1S/C24H20F3N3O/c1-13-7-21-22(11-19(13)24(25,26)27)30-23(31)12-20(29-21)17-6-4-5-16(10-17)18-8-14(2)28-15(3)9-18/h4-11H,12H2,1-3H3,(H,30,31)
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of mGlu3 by cell-based assay


Bioorg Med Chem Lett 22: 3921-5 (2012)

More data for this
Ligand-Target Pair
metabotropic glutamate 1c


(HUMAN)
BDBM50332963
PNG
(4-(3-(2,6-dimethylpyridin-4-yl)phenyl)-7-methyl-8-...)
Show SMILES Cc1cc(cc(C)n1)-c1cccc(c1)C1=Nc2cc(C)c(cc2NC(=O)C1)C(F)(F)F
Show InChI InChI=1S/C24H20F3N3O/c1-13-7-21-22(11-19(13)24(25,26)27)30-23(31)12-20(29-21)17-6-4-5-16(10-17)18-8-14(2)28-15(3)9-18/h4-11H,12H2,1-3H3,(H,30,31)
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of mGlu3 receptor (unknown origin)


J Med Chem 56: 5208-12 (2013)

More data for this
Ligand-Target Pair
metabotropic glutamate 1c


(HUMAN)
BDBM50455206
PNG
(CHEMBL2311086)
Show SMILES N[C@](CC(c1ccccc1)c1ccccc1)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C20H21NO4/c21-20(19(24)25,17-11-15(17)18(22)23)12-16(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10,15-17H,11-12,21H2,(H,22,23)(H,24,25)/t15-,17-,20+/m0/s1
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Ability to block 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in non-neuronal cell line expressing human Metabotropic glutamate r...


J Med Chem 41: 346-57 (1998)

More data for this
Ligand-Target Pair
metabotropic glutamate 1c


(HUMAN)
BDBM50064444
PNG
(CHEMBL3401195)
Show SMILES Fc1ccc(cc1)N1CCc2nc(COc3ccccc3)cn2C1=O
Show InChI InChI=1S/C19H16FN3O2/c20-14-6-8-16(9-7-14)22-11-10-18-21-15(12-23(18)19(22)24)13-25-17-4-2-1-3-5-17/h1-9,12H,10-11,13H2
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Janssen Research and Development

Curated by ChEMBL


Assay Description
Negative allosteric modulation at mGluR3 (unknown origin)


Bioorg Med Chem Lett 25: 1310-7 (2015)

More data for this
Ligand-Target Pair
metabotropic glutamate 1c


(HUMAN)
BDBM50062538
PNG
((S)-2-[(R)-1-Amino-1-carboxy-3-(3-trifluoromethyl-...)
Show SMILES N[C@](CCc1cccc(c1)C(F)(F)F)(C1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C15H16F3NO4/c16-15(17,18)9-3-1-2-8(6-9)4-5-14(19,13(22)23)11-7-10(11)12(20)21/h1-3,6,10-11H,4-5,7,19H2,(H,20,21)(H,22,23)/t10-,11?,14+/m0/s1
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n/an/a 420n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3


J Med Chem 41: 358-78 (1998)

More data for this
Ligand-Target Pair
metabotropic glutamate 1c


(HUMAN)
BDBM50121651
PNG
(CHEMBL3616850)
Show SMILES N[C@]1(C[C@@H](Sc2nnc([nH]2)C(F)F)[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Show InChI InChI=1/C11H12F2N4O4S/c12-6(13)7-15-10(17-16-7)22-2-1-11(14,9(20)21)5-3(2)4(5)8(18)19/h2-6H,1,14H2,(H,18,19)(H,20,21)(H,15,16,17)/t2-,3+,4+,5+,11+/s2
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n/an/a 459n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant mGlu3 receptor expressed in AV12 cells assessed as reversal of DCG-4-inhibited, forskolin-stimulated cAMP pr...


J Med Chem 58: 7526-48 (2015)

More data for this
Ligand-Target Pair
metabotropic glutamate 1c


(HUMAN)
BDBM50408687
PNG
(CHEMBL2112583)
Show SMILES NC(CCc1cccc2ccccc12)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C18H19NO4/c19-18(17(22)23,15-10-14(15)16(20)21)9-8-12-6-3-5-11-4-1-2-7-13(11)12/h1-7,14-15H,8-10,19H2,(H,20,21)(H,22,23)/t14-,15-,18?/m0/s1
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n/an/a 470n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Ability to block 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in non-neuronal cell line expressing human Metabotropic glutamate r...


J Med Chem 41: 346-57 (1998)

More data for this
Ligand-Target Pair
metabotropic glutamate 1c


(HUMAN)
BDBM50121647
PNG
(CHEMBL3616849)
Show SMILES N[C@]1(C[C@@H](Sc2nnc([nH]2)C(F)(F)F)[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Show InChI InChI=1/C11H11F3N4O4S/c12-11(13,14)7-16-9(18-17-7)23-2-1-10(15,8(21)22)5-3(2)4(5)6(19)20/h2-5H,1,15H2,(H,19,20)(H,21,22)(H,16,17,18)/t2-,3+,4+,5+,10+/s2
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n/an/a 528n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant mGlu3 receptor expressed in AV12 cells assessed as reversal of DCG-4-inhibited, forskolin-stimulated cAMP pr...


J Med Chem 58: 7526-48 (2015)

More data for this
Ligand-Target Pair
metabotropic glutamate 1c


(HUMAN)
BDBM50408692
PNG
(CHEMBL2112584)
Show SMILES NC(CCCc1ccccc1)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C15H19NO4/c16-15(14(19)20,12-9-11(12)13(17)18)8-4-7-10-5-2-1-3-6-10/h1-3,5-6,11-12H,4,7-9,16H2,(H,17,18)(H,19,20)/t11-,12-,15?/m0/s1
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n/an/a 550n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Ability to block 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in non-neuronal cell line expressing human Metabotropic glutamate r...


J Med Chem 41: 346-57 (1998)

More data for this
Ligand-Target Pair
metabotropic glutamate 1c


(HUMAN)
BDBM50408694
PNG
(CHEMBL2112581)
Show SMILES NC(CCc1ccsc1)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C12H15NO4S/c13-12(11(16)17,9-5-8(9)10(14)15)3-1-7-2-4-18-6-7/h2,4,6,8-9H,1,3,5,13H2,(H,14,15)(H,16,17)/t8-,9-,12?/m0/s1
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n/an/a 570n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Ability to block 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in non-neuronal cell line expressing human Metabotropic glutamate r...


J Med Chem 41: 346-57 (1998)

More data for this
Ligand-Target Pair
metabotropic glutamate 1c


(HUMAN)
BDBM50121539
PNG
(CHEMBL3616856)
Show SMILES N[C@]1(C[C@H](Sc2nnc([nH]2)C(F)(F)F)[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Show InChI InChI=1/C11H11F3N4O4S/c12-11(13,14)7-16-9(18-17-7)23-2-1-10(15,8(21)22)5-3(2)4(5)6(19)20/h2-5H,1,15H2,(H,19,20)(H,21,22)(H,16,17,18)/t2-,3-,4-,5-,10-/s2
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n/an/a 624n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant mGlu3 receptor expressed in AV12 cells assessed as inhibition of glutamate-stimulated Ca2+ mobilization afte...


J Med Chem 58: 7526-48 (2015)

More data for this
Ligand-Target Pair
metabotropic glutamate 1c


(HUMAN)
BDBM50064463
PNG
(CHEMBL3401177)
Show SMILES Fc1ccc(cc1)-n1ccc2nc(COc3ccccc3)cn2c1=O
Show InChI InChI=1S/C19H14FN3O2/c20-14-6-8-16(9-7-14)22-11-10-18-21-15(12-23(18)19(22)24)13-25-17-4-2-1-3-5-17/h1-12H,13H2
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n/an/a 630n/an/an/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Negative allosteric modulation at mGluR3 (unknown origin)


Bioorg Med Chem Lett 25: 1310-7 (2015)

More data for this
Ligand-Target Pair
metabotropic glutamate 1c


(HUMAN)
BDBM50408693
PNG
(CHEMBL2112582)
Show SMILES NC(CCc1ccccc1)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C14H17NO4/c15-14(13(18)19,11-8-10(11)12(16)17)7-6-9-4-2-1-3-5-9/h1-5,10-11H,6-8,15H2,(H,16,17)(H,18,19)/t10-,11-,14?/m0/s1
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n/an/a 650n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3


J Med Chem 41: 358-78 (1998)

More data for this
Ligand-Target Pair
metabotropic glutamate 1c


(HUMAN)
BDBM50408693
PNG
(CHEMBL2112582)
Show SMILES NC(CCc1ccccc1)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C14H17NO4/c15-14(13(18)19,11-8-10(11)12(16)17)7-6-9-4-2-1-3-5-9/h1-5,10-11H,6-8,15H2,(H,16,17)(H,18,19)/t10-,11-,14?/m0/s1
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n/an/a 650n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Ability to block 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in non-neuronal cell line expressing human Metabotropic glutamate r...


J Med Chem 41: 346-57 (1998)

More data for this
Ligand-Target Pair
metabotropic glutamate 1c


(HUMAN)
BDBM50401086
PNG
(CHEMBL2204445)
Show SMILES COc1ccc(cc1)C#Cc1ccc(cc1)C(=O)N1CCC[C@@H](CO)C1
Show InChI InChI=1S/C22H23NO3/c1-26-21-12-8-18(9-13-21)5-4-17-6-10-20(11-7-17)22(25)23-14-2-3-19(15-23)16-24/h6-13,19,24H,2-3,14-16H2,1H3/t19-/m1/s1
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n/an/a 660n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of mGlu3 assessed as inhibition of glutamate-induced calcium mobilization in presence of Galpha15 by cell based assay


Bioorg Med Chem Lett 22: 3921-5 (2012)

More data for this
Ligand-Target Pair
metabotropic glutamate 1c


(HUMAN)
BDBM50408688
PNG
(CHEMBL2112586)
Show SMILES NC(CCC12CC3CC(CC(C3)C1)C2)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C18H27NO4/c19-18(16(22)23,14-6-13(14)15(20)21)2-1-17-7-10-3-11(8-17)5-12(4-10)9-17/h10-14H,1-9,19H2,(H,20,21)(H,22,23)/t10?,11?,12?,13-,14-,17?,18?/m0/s1
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n/an/a 760n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Ability to block 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in non-neuronal cell line expressing human Metabotropic glutamate r...


J Med Chem 41: 346-57 (1998)

More data for this
Ligand-Target Pair
metabotropic glutamate 1c


(HUMAN)
BDBM50121653
PNG
(CHEMBL3616852)
Show SMILES CC(C)c1nnc(S[C@@H]2C[C@](N)([C@H]3[C@@H]2[C@@H]3C(O)=O)C(O)=O)[nH]1
Show InChI InChI=1/C13H18N4O4S/c1-4(2)9-15-12(17-16-9)22-5-3-13(14,11(20)21)8-6(5)7(8)10(18)19/h4-8H,3,14H2,1-2H3,(H,18,19)(H,20,21)(H,15,16,17)/t5-,6+,7+,8+,13+/s2
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n/an/a 859n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant mGlu3 receptor expressed in AV12 cells assessed as reversal of DCG-4-inhibited, forskolin-stimulated cAMP pr...


J Med Chem 58: 7526-48 (2015)

More data for this
Ligand-Target Pair
metabotropic glutamate 1c


(HUMAN)
BDBM50434139
PNG
(CHEMBL2381650)
Show SMILES N[C@]1(C[C@@H](Sc2ccccc2)[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H15NO4S/c15-14(13(18)19)6-8(9-10(11(9)14)12(16)17)20-7-4-2-1-3-5-7/h1-5,8-11H,6,15H2,(H,16,17)(H,18,19)/t8-,9+,10+,11+,14+/m1/s1
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n/an/a 895n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human mGlu3 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 assessed as inhibition of forskolin-stim...


J Med Chem 56: 4442-55 (2013)

More data for this
Ligand-Target Pair
metabotropic glutamate 1c


(HUMAN)
BDBM50167032
PNG
((1S,2S,4R,5R,6S)-2-Amino-4-methyl-bicyclo[3.1.0]he...)
Show SMILES C[C@@H]1C[C@](N)([C@H]2[C@@H]1[C@@H]2C(O)=O)C(O)=O
Show InChI InChI=1S/C9H13NO4/c1-3-2-9(10,8(13)14)6-4(3)5(6)7(11)12/h3-6H,2,10H2,1H3,(H,11,12)(H,13,14)/t3-,4+,5+,6+,9+/m1/s1
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n/an/a 1.05E+3n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Evaluation of the functional effect on cAMP responses in RGT cells expressing human mGlu3 receptor


J Med Chem 48: 3605-12 (2005)

More data for this
Ligand-Target Pair
metabotropic glutamate 1c


(HUMAN)
BDBM50434139
PNG
(CHEMBL2381650)
Show SMILES N[C@]1(C[C@@H](Sc2ccccc2)[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H15NO4S/c15-14(13(18)19)6-8(9-10(11(9)14)12(16)17)20-7-4-2-1-3-5-7/h1-5,8-11H,6,15H2,(H,16,17)(H,18,19)/t8-,9+,10+,11+,14+/m1/s1
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n/an/a 1.07E+3n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant mGlu3 receptor expressed in AV12 cells assessed as reversal of DCG-4-inhibited, forskolin-stimulated cAMP pr...


J Med Chem 58: 7526-48 (2015)

More data for this
Ligand-Target Pair
metabotropic glutamate 1c


(HUMAN)
BDBM50408691
PNG
(CHEMBL2112580)
Show SMILES Cn1cc(CCC(N)([C@H]2C[C@@H]2C(O)=O)C(O)=O)c2ccccc12
Show InChI InChI=1S/C17H20N2O4/c1-19-9-10(11-4-2-3-5-14(11)19)6-7-17(18,16(22)23)13-8-12(13)15(20)21/h2-5,9,12-13H,6-8,18H2,1H3,(H,20,21)(H,22,23)/t12-,13-,17?/m0/s1
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n/an/a 1.20E+3n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Ability to block 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in non-neuronal cell line expressing human Metabotropic glutamate r...


J Med Chem 41: 346-57 (1998)

More data for this
Ligand-Target Pair
metabotropic glutamate 1c


(HUMAN)
BDBM50408695
PNG
(CHEMBL2112574)
Show SMILES NC(CC1CCCCC1)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C13H21NO4/c14-13(12(17)18,10-6-9(10)11(15)16)7-8-4-2-1-3-5-8/h8-10H,1-7,14H2,(H,15,16)(H,17,18)/t9-,10-,13?/m0/s1
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n/an/a 1.40E+3n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Ability to block 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in non-neuronal cell line expressing human Metabotropic glutamate r...


J Med Chem 41: 346-57 (1998)

More data for this
Ligand-Target Pair
metabotropic glutamate 1c


(HUMAN)
BDBM50401086
PNG
(CHEMBL2204445)
Show SMILES COc1ccc(cc1)C#Cc1ccc(cc1)C(=O)N1CCC[C@@H](CO)C1
Show InChI InChI=1S/C22H23NO3/c1-26-21-12-8-18(9-13-21)5-4-17-6-10-20(11-7-17)22(25)23-14-2-3-19(15-23)16-24/h6-13,19,24H,2-3,14-16H2,1H3/t19-/m1/s1
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n/an/a 1.48E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of mGlu3 assessed as thaillium flux through GIRK channels by cell-based assay


Bioorg Med Chem Lett 22: 3921-5 (2012)

More data for this
Ligand-Target Pair
metabotropic glutamate 1c


(HUMAN)
BDBM50401086
PNG
(CHEMBL2204445)
Show SMILES COc1ccc(cc1)C#Cc1ccc(cc1)C(=O)N1CCC[C@@H](CO)C1
Show InChI InChI=1S/C22H23NO3/c1-26-21-12-8-18(9-13-21)5-4-17-6-10-20(11-7-17)22(25)23-14-2-3-19(15-23)16-24/h6-13,19,24H,2-3,14-16H2,1H3/t19-/m1/s1
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n/an/a 1.50E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of mGlu3 assessed as thaillium flux through GIRK channels by cell-based assay


Bioorg Med Chem Lett 22: 3921-5 (2012)

More data for this
Ligand-Target Pair
metabotropic glutamate 1c


(HUMAN)
BDBM50062495
PNG
((S)-2-((R)-1-Amino-1-carboxy-3-methyl-butyl)-cyclo...)
Show SMILES CC(C)C[C@@](N)(C1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C10H17NO4/c1-5(2)4-10(11,9(14)15)7-3-6(7)8(12)13/h5-7H,3-4,11H2,1-2H3,(H,12,13)(H,14,15)/t6-,7?,10+/m0/s1
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n/an/a 1.80E+3n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Ability to block 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in non-neuronal cell line expressing human Metabotropic glutamate r...


J Med Chem 41: 346-57 (1998)

More data for this
Ligand-Target Pair
metabotropic glutamate 1c


(HUMAN)
BDBM50401085
PNG
(CHEMBL2204446)
Show SMILES COc1ccc(cc1)C#Cc1ccc(cc1)C(=O)N1CCC[C@H](CO)C1
Show InChI InChI=1S/C22H23NO3/c1-26-21-12-8-18(9-13-21)5-4-17-6-10-20(11-7-17)22(25)23-14-2-3-19(15-23)16-24/h6-13,19,24H,2-3,14-16H2,1H3/t19-/m0/s1
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n/an/a 2.04E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of mGlu3 assessed as thaillium flux through GIRK channels by cell-based assay


Bioorg Med Chem Lett 22: 3921-5 (2012)

More data for this
Ligand-Target Pair
metabotropic glutamate 1c


(HUMAN)
BDBM50401085
PNG
(CHEMBL2204446)
Show SMILES COc1ccc(cc1)C#Cc1ccc(cc1)C(=O)N1CCC[C@H](CO)C1
Show InChI InChI=1S/C22H23NO3/c1-26-21-12-8-18(9-13-21)5-4-17-6-10-20(11-7-17)22(25)23-14-2-3-19(15-23)16-24/h6-13,19,24H,2-3,14-16H2,1H3/t19-/m0/s1
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n/an/a 2.10E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of mGlu3 assessed as thaillium flux through GIRK channels by cell-based assay


Bioorg Med Chem Lett 22: 3921-5 (2012)

More data for this
Ligand-Target Pair
metabotropic glutamate 1c


(HUMAN)
BDBM50121641
PNG
(CHEMBL3616859)
Show SMILES CC(C)c1nnc(S[C@H]2C[C@](N)([C@H]3[C@@H]2[C@@H]3C(O)=O)C(O)=O)[nH]1
Show InChI InChI=1/C13H18N4O4S/c1-4(2)9-15-12(17-16-9)22-5-3-13(14,11(20)21)8-6(5)7(8)10(18)19/h4-8H,3,14H2,1-2H3,(H,18,19)(H,20,21)(H,15,16,17)/t5-,6-,7-,8-,13-/s2
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n/an/a 2.35E+3n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant mGlu3 receptor expressed in AV12 cells assessed as inhibition of glutamate-stimulated Ca2+ mobilization afte...


J Med Chem 58: 7526-48 (2015)

More data for this
Ligand-Target Pair
metabotropic glutamate 1c


(HUMAN)
BDBM50121654
PNG
(CHEMBL3616853)
Show SMILES N[C@]1(C[C@@H](Sc2c[nH]nn2)[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Show InChI InChI=1/C10H12N4O4S/c11-10(9(17)18)1-3(19-4-2-12-14-13-4)5-6(7(5)10)8(15)16/h2-3,5-7H,1,11H2,(H,15,16)(H,17,18)(H,12,13,14)/t3-,5+,6+,7+,10+/s2
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n/an/a 2.38E+3n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant mGlu3 receptor expressed in AV12 cells assessed as reversal of DCG-4-inhibited, forskolin-stimulated cAMP pr...


J Med Chem 58: 7526-48 (2015)

More data for this
Ligand-Target Pair
metabotropic glutamate 1c


(HUMAN)
BDBM50401088
PNG
(CHEMBL2204439)
Show SMILES COc1ccc(cc1)C#Cc1ccc(cc1)C(=O)N1CCCC(O)C1
Show InChI InChI=1S/C21H21NO3/c1-25-20-12-8-17(9-13-20)5-4-16-6-10-18(11-7-16)21(24)22-14-2-3-19(23)15-22/h6-13,19,23H,2-3,14-15H2,1H3
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n/an/a 2.45E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of mGlu3 assessed as thaillium flux through GIRK channels by cell-based assay


Bioorg Med Chem Lett 22: 3921-5 (2012)

More data for this
Ligand-Target Pair
metabotropic glutamate 1c


(HUMAN)
BDBM50408689
PNG
(CHEMBL2112579)
Show SMILES CCC(N)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C8H13NO4/c1-2-8(9,7(12)13)5-3-4(5)6(10)11/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)/t4-,5-,8?/m0/s1
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n/an/a 2.50E+3n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Ability to block 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in non-neuronal cell line expressing human Metabotropic glutamate r...


J Med Chem 41: 346-57 (1998)

More data for this
Ligand-Target Pair
metabotropic glutamate 1c


(HUMAN)
BDBM50401088
PNG
(CHEMBL2204439)
Show SMILES COc1ccc(cc1)C#Cc1ccc(cc1)C(=O)N1CCCC(O)C1
Show InChI InChI=1S/C21H21NO3/c1-25-20-12-8-17(9-13-20)5-4-16-6-10-18(11-7-16)21(24)22-14-2-3-19(23)15-22/h6-13,19,23H,2-3,14-15H2,1H3
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n/an/a 2.50E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of mGlu3 assessed as thaillium flux through GIRK channels by cell-based assay


Bioorg Med Chem Lett 22: 3921-5 (2012)

More data for this
Ligand-Target Pair
metabotropic glutamate 1c


(HUMAN)
BDBM50121643
PNG
(CHEMBL3616847)
Show SMILES N[C@]1(C[C@@H](Sc2nnc[nH]2)[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Show InChI InChI=1/C10H12N4O4S/c11-10(8(17)18)1-3(19-9-12-2-13-14-9)4-5(6(4)10)7(15)16/h2-6H,1,11H2,(H,15,16)(H,17,18)(H,12,13,14)/t3-,4+,5+,6+,10+/s2
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n/an/a 2.73E+3n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant mGlu3 receptor expressed in AV12 cells assessed as reversal of DCG-4-inhibited, forskolin-stimulated cAMP pr...


J Med Chem 58: 7526-48 (2015)

More data for this
Ligand-Target Pair
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