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Compile Data Set for Download or QSAR

Found 260 hits Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 3'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 3


(Homo sapiens)
BDBM50062522
PNG
((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)
Show SMILES N[C@@](CC1c2ccccc2Oc2ccccc12)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C20H19NO5/c21-20(19(24)25,15-9-13(15)18(22)23)10-14-11-5-1-3-7-16(11)26-17-8-4-2-6-12(14)17/h1-8,13-15H,9-10,21H2,(H,22,23)(H,24,25)/t13-,15-,20-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Metabotropic glutamate receptor 3


(Homo sapiens)
BDBM50062522
PNG
((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)
Show SMILES N[C@@](CC1c2ccccc2Oc2ccccc12)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C20H19NO5/c21-20(19(24)25,15-9-13(15)18(22)23)10-14-11-5-1-3-7-16(11)26-17-8-4-2-6-12(14)17/h1-8,13-15H,9-10,21H2,(H,22,23)(H,24,25)/t13-,15-,20-/m0/s1
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n/an/a 14n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Antagonist activity at human mGLUR3 expressed in RGT cells assessed as inhibition of (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid-induced inhibi...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Metabotropic glutamate receptor 3


(Homo sapiens)
BDBM50279772
PNG
(2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-cy...)
Show SMILES N[C@](CC1c2ccccc2Oc2ccccc12)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C20H19NO5/c21-20(19(24)25,15-9-13(15)18(22)23)10-14-11-5-1-3-7-16(11)26-17-8-4-2-6-12(14)17/h1-8,13-15H,9-10,21H2,(H,22,23)(H,24,25)/t13-,15-,20+/m0/s1
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n/an/a 16n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Ability to block 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in non-neuronal cell line expressing human Metabotropic glutamate r...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens)
BDBM50151435
PNG
((1R,2R,3R,5R,6R)-2-Amino-3-(3,4-dichloro-benzyloxy...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1ccc(Cl)c(Cl)c1)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H14Cl2FNO5/c16-8-2-1-6(3-9(8)17)5-24-10-4-7-11(14(7,18)12(20)21)15(10,19)13(22)23/h1-3,7,10-11H,4-5,19H2,(H,20,21)(H,22,23)/t7-,10-,11+,14-,15+/m1/s1
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n/an/a 24n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Antagonist activity at mGLUR3 expressed in CHO cells assessed as inhibition of glutamate-induced inhibition of forskolin-stimulated cAMP production


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens)
BDBM50062520
PNG
((1S,2S)-2-((R)-1-Amino-1-carboxy-3-m-tolyl-propyl)...)
Show SMILES Cc1cccc(CC[C@@](N)([C@H]2C[C@@H]2C(O)=O)C(O)=O)c1
Show InChI InChI=1S/C15H19NO4/c1-9-3-2-4-10(7-9)5-6-15(16,14(19)20)12-8-11(12)13(17)18/h2-4,7,11-12H,5-6,8,16H2,1H3,(H,17,18)(H,19,20)/t11-,12-,15+/m0/s1
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n/an/a 80n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens)
BDBM50408697
PNG
(CHEMBL2112634)
Show SMILES NC(CCc1cccc(c1)C(O)=O)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C15H17NO6/c16-15(14(21)22,11-7-10(11)13(19)20)5-4-8-2-1-3-9(6-8)12(17)18/h1-3,6,10-11H,4-5,7,16H2,(H,17,18)(H,19,20)(H,21,22)/t10-,11-,15?/m0/s1
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n/an/a 80n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens)
BDBM50121652
PNG
(CHEMBL3616851)
Show SMILES Nc1nnc(S[C@@H]2C[C@](N)([C@H]3[C@@H]2[C@@H]3C(O)=O)C(O)=O)[nH]1
Show InChI InChI=1/C10H13N5O4S/c11-8-13-9(15-14-8)20-2-1-10(12,7(18)19)5-3(2)4(5)6(16)17/h2-5H,1,12H2,(H,16,17)(H,18,19)(H3,11,13,14,15)/t2-,3+,4+,5+,10+/s2
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n/an/a 95n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant mGlu3 receptor expressed in AV12 cells assessed as inhibition of glutamate-stimulated Ca2+ mobilization afte...


J Med Chem 58: 7526-48 (2015)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens)
BDBM50121651
PNG
(CHEMBL3616850)
Show SMILES N[C@]1(C[C@@H](Sc2nnc([nH]2)C(F)F)[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Show InChI InChI=1/C11H12F2N4O4S/c12-6(13)7-15-10(17-16-7)22-2-1-11(14,9(20)21)5-3(2)4(5)8(18)19/h2-6H,1,14H2,(H,18,19)(H,20,21)(H,15,16,17)/t2-,3+,4+,5+,11+/s2
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n/an/a 154n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant mGlu3 receptor expressed in AV12 cells assessed as inhibition of glutamate-stimulated Ca2+ mobilization afte...


J Med Chem 58: 7526-48 (2015)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens)
BDBM50062534
PNG
((S)-2-[(R)-1-Amino-1-carboxy-3-(3-methoxy-phenyl)-...)
Show SMILES COc1cccc(CC[C@@](N)(C2C[C@@H]2C(O)=O)C(O)=O)c1
Show InChI InChI=1S/C15H19NO5/c1-21-10-4-2-3-9(7-10)5-6-15(16,14(19)20)12-8-11(12)13(17)18/h2-4,7,11-12H,5-6,8,16H2,1H3,(H,17,18)(H,19,20)/t11-,12?,15+/m0/s1
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n/an/a 160n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens)
BDBM50062543
PNG
((1S,2S)-2-((S)-1-Amino-1-carboxy-3,3-diphenyl-prop...)
Show SMILES N[C@@](CC(c1ccccc1)c1ccccc1)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C20H21NO4/c21-20(19(24)25,17-11-15(17)18(22)23)12-16(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10,15-17H,11-12,21H2,(H,22,23)(H,24,25)/t15-,17-,20-/m0/s1
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n/an/a 170n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens)
BDBM50062518
PNG
((S)-2-[(R)-1-Amino-1-carboxy-3-(3-chloro-phenyl)-p...)
Show SMILES N[C@](CCc1cccc(Cl)c1)(C1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C14H16ClNO4/c15-9-3-1-2-8(6-9)4-5-14(16,13(19)20)11-7-10(11)12(17)18/h1-3,6,10-11H,4-5,7,16H2,(H,17,18)(H,19,20)/t10-,11?,14+/m0/s1
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n/an/a 180n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens)
BDBM50408696
PNG
(CHEMBL2111822)
Show SMILES CS(=O)(=O)c1cccc(CC[C@@](N)(C2C[C@@H]2C(O)=O)C(O)=O)c1
Show InChI InChI=1S/C15H19NO6S/c1-23(21,22)10-4-2-3-9(7-10)5-6-15(16,14(19)20)12-8-11(12)13(17)18/h2-4,7,11-12H,5-6,8,16H2,1H3,(H,17,18)(H,19,20)/t11-,12?,15+/m0/s1
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n/an/a 180n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens)
BDBM50401091
PNG
(CHEMBL2204436 | CHEMBL2385894)
Show SMILES Clc1ccc(CN[C@H]2CCN(C2)c2ncc(Br)cn2)c(Cl)c1
Show InChI InChI=1S/C15H15BrCl2N4/c16-11-7-20-15(21-8-11)22-4-3-13(9-22)19-6-10-1-2-12(17)5-14(10)18/h1-2,5,7-8,13,19H,3-4,6,9H2/t13-/m0/s1
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n/an/a 190n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGlu3 expressed in AV-12 cells in presence of glutamate EC90 concentration by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens)
BDBM50062539
PNG
((S)-2-[(R)-1-Amino-3-(3-amino-phenyl)-1-carboxy-pr...)
Show SMILES Nc1cccc(CC[C@@](N)(C2C[C@@H]2C(O)=O)C(O)=O)c1
Show InChI InChI=1S/C14H18N2O4/c15-9-3-1-2-8(6-9)4-5-14(16,13(19)20)11-7-10(11)12(17)18/h1-3,6,10-11H,4-5,7,15-16H2,(H,17,18)(H,19,20)/t10-,11?,14+/m0/s1
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n/an/a 200n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens)
BDBM50062526
PNG
((S)-2-[(R)-1-Amino-1-carboxy-3-(4-fluoro-phenyl)-p...)
Show SMILES N[C@](CCc1ccc(F)cc1)(C1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C14H16FNO4/c15-9-3-1-8(2-4-9)5-6-14(16,13(19)20)11-7-10(11)12(17)18/h1-4,10-11H,5-7,16H2,(H,17,18)(H,19,20)/t10-,11?,14+/m0/s1
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n/an/a 210n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens)
BDBM50121540
PNG
(CHEMBL3616857)
Show SMILES N[C@]1(C[C@H](Sc2nnc([nH]2)C(F)F)[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Show InChI InChI=1/C11H12F2N4O4S/c12-6(13)7-15-10(17-16-7)22-2-1-11(14,9(20)21)5-3(2)4(5)8(18)19/h2-6H,1,14H2,(H,18,19)(H,20,21)(H,15,16,17)/t2-,3-,4-,5-,11-/s2
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n/an/a 244n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant mGlu3 receptor expressed in AV12 cells assessed as inhibition of glutamate-stimulated Ca2+ mobilization afte...


J Med Chem 58: 7526-48 (2015)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens)
BDBM50062529
PNG
((S)-2-[(R)-1-Amino-1-carboxy-3-(3-hydroxy-phenyl)-...)
Show SMILES N[C@](CCc1cccc(O)c1)(C1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C14H17NO5/c15-14(13(19)20,11-7-10(11)12(17)18)5-4-8-2-1-3-9(16)6-8/h1-3,6,10-11,16H,4-5,7,15H2,(H,17,18)(H,19,20)/t10-,11?,14+/m0/s1
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n/an/a 260n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens)
BDBM50332963
PNG
(4-(3-(2,6-dimethylpyridin-4-yl)phenyl)-7-methyl-8-...)
Show SMILES Cc1cc(cc(C)n1)-c1cccc(c1)C1=Nc2cc(C)c(cc2NC(=O)C1)C(F)(F)F
Show InChI InChI=1S/C24H20F3N3O/c1-13-7-21-22(11-19(13)24(25,26)27)30-23(31)12-20(29-21)17-6-4-5-16(10-17)18-8-14(2)28-15(3)9-18/h4-11H,12H2,1-3H3,(H,30,31)
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n/an/a 270n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of mGlu3 by cell-based assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens)
BDBM50332963
PNG
(4-(3-(2,6-dimethylpyridin-4-yl)phenyl)-7-methyl-8-...)
Show SMILES Cc1cc(cc(C)n1)-c1cccc(c1)C1=Nc2cc(C)c(cc2NC(=O)C1)C(F)(F)F
Show InChI InChI=1S/C24H20F3N3O/c1-13-7-21-22(11-19(13)24(25,26)27)30-23(31)12-20(29-21)17-6-4-5-16(10-17)18-8-14(2)28-15(3)9-18/h4-11H,12H2,1-3H3,(H,30,31)
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n/an/a 270n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of mGlu3 receptor (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens)
BDBM50455206
PNG
(CHEMBL2311086)
Show SMILES N[C@](CC(c1ccccc1)c1ccccc1)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C20H21NO4/c21-20(19(24)25,17-11-15(17)18(22)23)12-16(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10,15-17H,11-12,21H2,(H,22,23)(H,24,25)/t15-,17-,20+/m0/s1
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n/an/a 280n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Ability to block 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in non-neuronal cell line expressing human Metabotropic glutamate r...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens)
BDBM50064444
PNG
(CHEMBL3401195)
Show SMILES Fc1ccc(cc1)N1CCc2nc(COc3ccccc3)cn2C1=O
Show InChI InChI=1S/C19H16FN3O2/c20-14-6-8-16(9-7-14)22-11-10-18-21-15(12-23(18)19(22)24)13-25-17-4-2-1-3-5-17/h1-9,12H,10-11,13H2
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n/an/a 290n/an/an/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Negative allosteric modulation at mGluR3 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens)
BDBM50062538
PNG
((S)-2-[(R)-1-Amino-1-carboxy-3-(3-trifluoromethyl-...)
Show SMILES N[C@](CCc1cccc(c1)C(F)(F)F)(C1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C15H16F3NO4/c16-15(17,18)9-3-1-2-8(6-9)4-5-14(19,13(22)23)11-7-10(11)12(20)21/h1-3,6,10-11H,4-5,7,19H2,(H,20,21)(H,22,23)/t10-,11?,14+/m0/s1
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n/an/a 420n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens)
BDBM50121651
PNG
(CHEMBL3616850)
Show SMILES N[C@]1(C[C@@H](Sc2nnc([nH]2)C(F)F)[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Show InChI InChI=1/C11H12F2N4O4S/c12-6(13)7-15-10(17-16-7)22-2-1-11(14,9(20)21)5-3(2)4(5)8(18)19/h2-6H,1,14H2,(H,18,19)(H,20,21)(H,15,16,17)/t2-,3+,4+,5+,11+/s2
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n/an/a 459n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant mGlu3 receptor expressed in AV12 cells assessed as reversal of DCG-4-inhibited, forskolin-stimulated cAMP pr...


J Med Chem 58: 7526-48 (2015)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens)
BDBM50408687
PNG
(CHEMBL2112583)
Show SMILES NC(CCc1cccc2ccccc12)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C18H19NO4/c19-18(17(22)23,15-10-14(15)16(20)21)9-8-12-6-3-5-11-4-1-2-7-13(11)12/h1-7,14-15H,8-10,19H2,(H,20,21)(H,22,23)/t14-,15-,18?/m0/s1
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n/an/a 470n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Ability to block 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in non-neuronal cell line expressing human Metabotropic glutamate r...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens)
BDBM50121647
PNG
(CHEMBL3616849)
Show SMILES N[C@]1(C[C@@H](Sc2nnc([nH]2)C(F)(F)F)[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Show InChI InChI=1/C11H11F3N4O4S/c12-11(13,14)7-16-9(18-17-7)23-2-1-10(15,8(21)22)5-3(2)4(5)6(19)20/h2-5H,1,15H2,(H,19,20)(H,21,22)(H,16,17,18)/t2-,3+,4+,5+,10+/s2
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n/an/a 528n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant mGlu3 receptor expressed in AV12 cells assessed as reversal of DCG-4-inhibited, forskolin-stimulated cAMP pr...


J Med Chem 58: 7526-48 (2015)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens)
BDBM50408692
PNG
(CHEMBL2112584)
Show SMILES NC(CCCc1ccccc1)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C15H19NO4/c16-15(14(19)20,12-9-11(12)13(17)18)8-4-7-10-5-2-1-3-6-10/h1-3,5-6,11-12H,4,7-9,16H2,(H,17,18)(H,19,20)/t11-,12-,15?/m0/s1
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n/an/a 550n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Ability to block 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in non-neuronal cell line expressing human Metabotropic glutamate r...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens)
BDBM50408694
PNG
(CHEMBL2112581)
Show SMILES NC(CCc1ccsc1)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C12H15NO4S/c13-12(11(16)17,9-5-8(9)10(14)15)3-1-7-2-4-18-6-7/h2,4,6,8-9H,1,3,5,13H2,(H,14,15)(H,16,17)/t8-,9-,12?/m0/s1
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n/an/a 570n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Ability to block 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in non-neuronal cell line expressing human Metabotropic glutamate r...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens)
BDBM50121539
PNG
(CHEMBL3616856)
Show SMILES N[C@]1(C[C@H](Sc2nnc([nH]2)C(F)(F)F)[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Show InChI InChI=1/C11H11F3N4O4S/c12-11(13,14)7-16-9(18-17-7)23-2-1-10(15,8(21)22)5-3(2)4(5)6(19)20/h2-5H,1,15H2,(H,19,20)(H,21,22)(H,16,17,18)/t2-,3-,4-,5-,10-/s2
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n/an/a 624n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant mGlu3 receptor expressed in AV12 cells assessed as inhibition of glutamate-stimulated Ca2+ mobilization afte...


J Med Chem 58: 7526-48 (2015)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens)
BDBM50064463
PNG
(CHEMBL3401177)
Show SMILES Fc1ccc(cc1)-n1ccc2nc(COc3ccccc3)cn2c1=O
Show InChI InChI=1S/C19H14FN3O2/c20-14-6-8-16(9-7-14)22-11-10-18-21-15(12-23(18)19(22)24)13-25-17-4-2-1-3-5-17/h1-12H,13H2
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n/an/a 630n/an/an/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Negative allosteric modulation at mGluR3 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens)
BDBM50408693
PNG
(CHEMBL2112582)
Show SMILES NC(CCc1ccccc1)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C14H17NO4/c15-14(13(18)19,11-8-10(11)12(16)17)7-6-9-4-2-1-3-5-9/h1-5,10-11H,6-8,15H2,(H,16,17)(H,18,19)/t10-,11-,14?/m0/s1
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n/an/a 650n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens)
BDBM50408693
PNG
(CHEMBL2112582)
Show SMILES NC(CCc1ccccc1)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C14H17NO4/c15-14(13(18)19,11-8-10(11)12(16)17)7-6-9-4-2-1-3-5-9/h1-5,10-11H,6-8,15H2,(H,16,17)(H,18,19)/t10-,11-,14?/m0/s1
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n/an/a 650n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Ability to block 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in non-neuronal cell line expressing human Metabotropic glutamate r...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens)
BDBM50401086
PNG
(CHEMBL2204445)
Show SMILES COc1ccc(cc1)C#Cc1ccc(cc1)C(=O)N1CCC[C@@H](CO)C1
Show InChI InChI=1S/C22H23NO3/c1-26-21-12-8-18(9-13-21)5-4-17-6-10-20(11-7-17)22(25)23-14-2-3-19(15-23)16-24/h6-13,19,24H,2-3,14-16H2,1H3/t19-/m1/s1
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n/an/a 660n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of mGlu3 assessed as inhibition of glutamate-induced calcium mobilization in presence of Galpha15 by cell based assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens)
BDBM50408688
PNG
(CHEMBL2112586)
Show SMILES NC(CCC12CC3CC(CC(C3)C1)C2)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C18H27NO4/c19-18(16(22)23,14-6-13(14)15(20)21)2-1-17-7-10-3-11(8-17)5-12(4-10)9-17/h10-14H,1-9,19H2,(H,20,21)(H,22,23)/t10?,11?,12?,13-,14-,17?,18?/m0/s1
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n/an/a 760n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Ability to block 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in non-neuronal cell line expressing human Metabotropic glutamate r...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens)
BDBM50121653
PNG
(CHEMBL3616852)
Show SMILES CC(C)c1nnc(S[C@@H]2C[C@](N)([C@H]3[C@@H]2[C@@H]3C(O)=O)C(O)=O)[nH]1
Show InChI InChI=1/C13H18N4O4S/c1-4(2)9-15-12(17-16-9)22-5-3-13(14,11(20)21)8-6(5)7(8)10(18)19/h4-8H,3,14H2,1-2H3,(H,18,19)(H,20,21)(H,15,16,17)/t5-,6+,7+,8+,13+/s2
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n/an/a 859n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant mGlu3 receptor expressed in AV12 cells assessed as reversal of DCG-4-inhibited, forskolin-stimulated cAMP pr...


J Med Chem 58: 7526-48 (2015)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens)
BDBM50434139
PNG
(CHEMBL2381650)
Show SMILES N[C@]1(C[C@@H](Sc2ccccc2)[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H15NO4S/c15-14(13(18)19)6-8(9-10(11(9)14)12(16)17)20-7-4-2-1-3-5-7/h1-5,8-11H,6,15H2,(H,16,17)(H,18,19)/t8-,9+,10+,11+,14+/m1/s1
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n/an/a 895n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human mGlu3 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 assessed as inhibition of forskolin-stim...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens)
BDBM50167032
PNG
((1S,2S,4R,5R,6S)-2-Amino-4-methyl-bicyclo[3.1.0]he...)
Show SMILES C[C@@H]1C[C@](N)([C@H]2[C@@H]1[C@@H]2C(O)=O)C(O)=O
Show InChI InChI=1S/C9H13NO4/c1-3-2-9(10,8(13)14)6-4(3)5(6)7(11)12/h3-6H,2,10H2,1H3,(H,11,12)(H,13,14)/t3-,4+,5+,6+,9+/m1/s1
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n/an/a 1.05E+3n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Evaluation of the functional effect on cAMP responses in RGT cells expressing human mGlu3 receptor


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens)
BDBM50434139
PNG
(CHEMBL2381650)
Show SMILES N[C@]1(C[C@@H](Sc2ccccc2)[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H15NO4S/c15-14(13(18)19)6-8(9-10(11(9)14)12(16)17)20-7-4-2-1-3-5-7/h1-5,8-11H,6,15H2,(H,16,17)(H,18,19)/t8-,9+,10+,11+,14+/m1/s1
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n/an/a 1.07E+3n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant mGlu3 receptor expressed in AV12 cells assessed as reversal of DCG-4-inhibited, forskolin-stimulated cAMP pr...


J Med Chem 58: 7526-48 (2015)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens)
BDBM50408691
PNG
(CHEMBL2112580)
Show SMILES Cn1cc(CCC(N)([C@H]2C[C@@H]2C(O)=O)C(O)=O)c2ccccc12
Show InChI InChI=1S/C17H20N2O4/c1-19-9-10(11-4-2-3-5-14(11)19)6-7-17(18,16(22)23)13-8-12(13)15(20)21/h2-5,9,12-13H,6-8,18H2,1H3,(H,20,21)(H,22,23)/t12-,13-,17?/m0/s1
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n/an/a 1.20E+3n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Ability to block 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in non-neuronal cell line expressing human Metabotropic glutamate r...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens)
BDBM50408695
PNG
(CHEMBL2112574)
Show SMILES NC(CC1CCCCC1)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C13H21NO4/c14-13(12(17)18,10-6-9(10)11(15)16)7-8-4-2-1-3-5-8/h8-10H,1-7,14H2,(H,15,16)(H,17,18)/t9-,10-,13?/m0/s1
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n/an/a 1.40E+3n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Ability to block 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in non-neuronal cell line expressing human Metabotropic glutamate r...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens)
BDBM50401086
PNG
(CHEMBL2204445)
Show SMILES COc1ccc(cc1)C#Cc1ccc(cc1)C(=O)N1CCC[C@@H](CO)C1
Show InChI InChI=1S/C22H23NO3/c1-26-21-12-8-18(9-13-21)5-4-17-6-10-20(11-7-17)22(25)23-14-2-3-19(15-23)16-24/h6-13,19,24H,2-3,14-16H2,1H3/t19-/m1/s1
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n/an/a 1.48E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of mGlu3 assessed as thaillium flux through GIRK channels by cell-based assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens)
BDBM50401086
PNG
(CHEMBL2204445)
Show SMILES COc1ccc(cc1)C#Cc1ccc(cc1)C(=O)N1CCC[C@@H](CO)C1
Show InChI InChI=1S/C22H23NO3/c1-26-21-12-8-18(9-13-21)5-4-17-6-10-20(11-7-17)22(25)23-14-2-3-19(15-23)16-24/h6-13,19,24H,2-3,14-16H2,1H3/t19-/m1/s1
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n/an/a 1.50E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of mGlu3 assessed as thaillium flux through GIRK channels by cell-based assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens)
BDBM50062495
PNG
((S)-2-((R)-1-Amino-1-carboxy-3-methyl-butyl)-cyclo...)
Show SMILES CC(C)C[C@@](N)(C1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C10H17NO4/c1-5(2)4-10(11,9(14)15)7-3-6(7)8(12)13/h5-7H,3-4,11H2,1-2H3,(H,12,13)(H,14,15)/t6-,7?,10+/m0/s1
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n/an/a 1.80E+3n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Ability to block 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in non-neuronal cell line expressing human Metabotropic glutamate r...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens)
BDBM50401085
PNG
(CHEMBL2204446)
Show SMILES COc1ccc(cc1)C#Cc1ccc(cc1)C(=O)N1CCC[C@H](CO)C1
Show InChI InChI=1S/C22H23NO3/c1-26-21-12-8-18(9-13-21)5-4-17-6-10-20(11-7-17)22(25)23-14-2-3-19(15-23)16-24/h6-13,19,24H,2-3,14-16H2,1H3/t19-/m0/s1
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n/an/a 2.04E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of mGlu3 assessed as thaillium flux through GIRK channels by cell-based assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens)
BDBM50401085
PNG
(CHEMBL2204446)
Show SMILES COc1ccc(cc1)C#Cc1ccc(cc1)C(=O)N1CCC[C@H](CO)C1
Show InChI InChI=1S/C22H23NO3/c1-26-21-12-8-18(9-13-21)5-4-17-6-10-20(11-7-17)22(25)23-14-2-3-19(15-23)16-24/h6-13,19,24H,2-3,14-16H2,1H3/t19-/m0/s1
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n/an/a 2.10E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of mGlu3 assessed as thaillium flux through GIRK channels by cell-based assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens)
BDBM50121641
PNG
(CHEMBL3616859)
Show SMILES CC(C)c1nnc(S[C@H]2C[C@](N)([C@H]3[C@@H]2[C@@H]3C(O)=O)C(O)=O)[nH]1
Show InChI InChI=1/C13H18N4O4S/c1-4(2)9-15-12(17-16-9)22-5-3-13(14,11(20)21)8-6(5)7(8)10(18)19/h4-8H,3,14H2,1-2H3,(H,18,19)(H,20,21)(H,15,16,17)/t5-,6-,7-,8-,13-/s2
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n/an/a 2.35E+3n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant mGlu3 receptor expressed in AV12 cells assessed as inhibition of glutamate-stimulated Ca2+ mobilization afte...


J Med Chem 58: 7526-48 (2015)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens)
BDBM50121654
PNG
(CHEMBL3616853)
Show SMILES N[C@]1(C[C@@H](Sc2c[nH]nn2)[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Show InChI InChI=1/C10H12N4O4S/c11-10(9(17)18)1-3(19-4-2-12-14-13-4)5-6(7(5)10)8(15)16/h2-3,5-7H,1,11H2,(H,15,16)(H,17,18)(H,12,13,14)/t3-,5+,6+,7+,10+/s2
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n/an/a 2.38E+3n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant mGlu3 receptor expressed in AV12 cells assessed as reversal of DCG-4-inhibited, forskolin-stimulated cAMP pr...


J Med Chem 58: 7526-48 (2015)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens)
BDBM50401088
PNG
(CHEMBL2204439)
Show SMILES COc1ccc(cc1)C#Cc1ccc(cc1)C(=O)N1CCCC(O)C1
Show InChI InChI=1S/C21H21NO3/c1-25-20-12-8-17(9-13-20)5-4-16-6-10-18(11-7-16)21(24)22-14-2-3-19(23)15-22/h6-13,19,23H,2-3,14-15H2,1H3
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n/an/a 2.45E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of mGlu3 assessed as thaillium flux through GIRK channels by cell-based assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens)
BDBM50408689
PNG
(CHEMBL2112579)
Show SMILES CCC(N)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C8H13NO4/c1-2-8(9,7(12)13)5-3-4(5)6(10)11/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)/t4-,5-,8?/m0/s1
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n/an/a 2.50E+3n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Ability to block 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in non-neuronal cell line expressing human Metabotropic glutamate r...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens)
BDBM50401088
PNG
(CHEMBL2204439)
Show SMILES COc1ccc(cc1)C#Cc1ccc(cc1)C(=O)N1CCCC(O)C1
Show InChI InChI=1S/C21H21NO3/c1-25-20-12-8-17(9-13-20)5-4-16-6-10-18(11-7-16)21(24)22-14-2-3-19(23)15-22/h6-13,19,23H,2-3,14-15H2,1H3
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n/an/a 2.50E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of mGlu3 assessed as thaillium flux through GIRK channels by cell-based assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens)
BDBM50121643
PNG
(CHEMBL3616847)
Show SMILES N[C@]1(C[C@@H](Sc2nnc[nH]2)[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Show InChI InChI=1/C10H12N4O4S/c11-10(8(17)18)1-3(19-9-12-2-13-14-9)4-5(6(4)10)7(15)16/h2-6H,1,11H2,(H,15,16)(H,17,18)(H,12,13,14)/t3-,4+,5+,6+,10+/s2
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n/an/a 2.73E+3n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant mGlu3 receptor expressed in AV12 cells assessed as reversal of DCG-4-inhibited, forskolin-stimulated cAMP pr...


J Med Chem 58: 7526-48 (2015)

More data for this
Ligand-Target Pair
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