Affinity DataIC50: 267nMAssay Description:Antagonist activity at human mGlu6 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 assessed as inhibition of forskolin-stim...More data for this Ligand-Target Pair
Affinity DataIC50: 750nMAssay Description:Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Taisho Pharmaceutical
Curated by ChEMBL
Taisho Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 1.14E+3nMAssay Description:Concentration required to inhibit metabotropic glutamate receptor 6 activity of rat expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.38E+3nMAssay Description:Antagonist activity at human mGlu6 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 assessed as inhibition of forskolin-stim...More data for this Ligand-Target Pair
Affinity DataIC50: 1.89E+3nMAssay Description:Antagonist activity at human mGlu6 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 assessed as inhibition of forskolin-stim...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Taisho Pharmaceutical
Curated by ChEMBL
Taisho Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 2.06E+3nMAssay Description:Concentration required to inhibit metabotropic glutamate receptor 6 activity of rat expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.40E+3nMAssay Description:Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.04E+3nMAssay Description:Antagonist activity at human mGlu6 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 assessed as inhibition of forskolin-stim...More data for this Ligand-Target Pair
Affinity DataIC50: 3.30E+3nMAssay Description:Antagonist activity at recombinant human mGlu6 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as inhibition of L-AP4-inh...More data for this Ligand-Target Pair
Affinity DataIC50: 3.50E+3nMAssay Description:Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.60E+3nMAssay Description:Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ...More data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+3nMAssay Description:Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ...More data for this Ligand-Target Pair
Affinity DataIC50: 4.01E+3nMAssay Description:Antagonist activity at human recombinant mGlu6 stably expressed in golden hamster AV12 cell membrane co-expressing Galpha15 assessed as reduction in ...More data for this Ligand-Target Pair
Affinity DataIC50: 4.10E+3nMAssay Description:Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ...More data for this Ligand-Target Pair
Affinity DataIC50: 4.50E+3nMAssay Description:Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ...More data for this Ligand-Target Pair
Affinity DataIC50: 5.70E+3nMAssay Description:Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ...More data for this Ligand-Target Pair
Affinity DataIC50: 6.50E+3nMAssay Description:Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ...More data for this Ligand-Target Pair
Affinity DataIC50: 8.60E+3nMAssay Description:Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ...More data for this Ligand-Target Pair
Affinity DataIC50: 9.22E+3nMAssay Description:Antagonist activity at mGluR6 (unknown origin) by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:In vitro inhibitory activity against angiotensin I converting enzyme of rats.More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Negative allosteric modulation of human mGlu6 receptor expressed in HEK cells harboring GIRK channel assessed as decrease in glutamate-induced thalli...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Negative allosteric modulation of mGlu6 receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Negative allosteric modulation of mGlu6 receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.06E+4nMAssay Description:Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+4nMAssay Description:Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.10E+4nMAssay Description:Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.30E+4nMAssay Description:Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ...More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Negative allosteric modulation of human mGlu6 receptor expressed in HEK cells harboring GIRK assessed as reduction in glutamate-induced thallium flux...More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Activity at mGlu6 receptor (unknown origin) expressed in HEK293 cells pre-treated for 15 mins before addition of EC80 concentration of reference agon...More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Antagonist activity at human mGlu6 receptor expressed in HEK293T cell membranes in presence of glutamate by GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Negative allosteric modulation of mGlu6R (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Negative allosteric modulation of human mGlu6 receptor expressed in HEK cells harboring GIRK assessed as reduction in glutamate-induced thallium flux...More data for this Ligand-Target Pair
Affinity DataIC50: 3.80E+4nMAssay Description:Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ...More data for this Ligand-Target Pair
Affinity DataIC50: 5.40E+4nMAssay Description:Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ...More data for this Ligand-Target Pair
Affinity DataIC50: 7.10E+4nMAssay Description:Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ...More data for this Ligand-Target Pair
Affinity DataIC50: 7.40E+4nMAssay Description:Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ...More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+5nMAssay Description:Compound was tested for its agonist activity against mGluR 2 receptor in CHO cells.More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+5nMAssay Description:Compound was tested for its agonist activity against mGluR 6 receptor in CHO cells.More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Taisho Pharmaceutical
Curated by ChEMBL
Taisho Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 4.80E+5nMAssay Description:Antagonistic activity of the compound against Metabotropic glutamate receptor 6 was determinedMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Taisho Pharmaceutical
Curated by ChEMBL
Taisho Pharmaceutical
Curated by ChEMBL
Affinity DataKi: 400nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 6 (mGluR-6).More data for this Ligand-Target Pair
Affinity DataKi: 900nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 6 (mGluR-6).More data for this Ligand-Target Pair
Affinity DataKi: 2.40E+3nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 6 (mGluR-6).More data for this Ligand-Target Pair
Affinity DataKi: 3.00E+3nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 6 (mGluR-6).More data for this Ligand-Target Pair
Affinity DataKi: 4.70E+3nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 6 (mGluR-6).More data for this Ligand-Target Pair
Affinity DataKi: 5.30E+3nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 6 (mGluR-6).More data for this Ligand-Target Pair
Affinity DataKi: 5.80E+3nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 6 (mGluR-6).More data for this Ligand-Target Pair