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Compile Data Set for Download or QSAR

Found 212 hits Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 8'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 8


(Homo sapiens)
BDBM50004051
PNG
(2-Amino-4-phosphono-butyric acid | 2-Amino-4-phosp...)
Show SMILES NC(CCP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)
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n/an/a 5.10n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against [3H]1 binding to recombinant human Metabotropic glutamate receptor 8


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens)
BDBM17657
PNG
((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Show SMILES N[C@@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
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n/an/a 5.70n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against [3H]1 binding to recombinant human Metabotropic glutamate receptor 8


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens)
BDBM50062522
PNG
((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)
Show SMILES N[C@@](CC1c2ccccc2Oc2ccccc12)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C20H19NO5/c21-20(19(24)25,15-9-13(15)18(22)23)10-14-11-5-1-3-7-16(11)26-17-8-4-2-6-12(14)17/h1-8,13-15H,9-10,21H2,(H,22,23)(H,24,25)/t13-,15-,20-/m0/s1
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n/an/a 170n/an/an/an/an/an/a



Centro de Investigación Lilly, SA

Curated by ChEMBL


Assay Description
Antagonistic activity against metabotropic glutamate receptor 8 (mGluR8) was evaluated


Bioorg Med Chem Lett 8: 2849-54 (1999)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens)
BDBM50072169
PNG
((1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl...)
Show SMILES CCCCC[C@@H]1[C@@H]([C@H]1C(N)(CC1c2ccccc2Oc2ccccc12)C(O)=O)C(O)=O
Show InChI InChI=1S/C25H29NO5/c1-2-3-4-11-17-21(23(27)28)22(17)25(26,24(29)30)14-18-15-9-5-7-12-19(15)31-20-13-8-6-10-16(18)20/h5-10,12-13,17-18,21-22H,2-4,11,14,26H2,1H3,(H,27,28)(H,29,30)/t17-,21+,22+,25?/m1/s1
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n/an/a 340n/an/an/an/an/an/a



Centro de Investigación Lilly, SA

Curated by ChEMBL


Assay Description
Antagonistic activity against metabotropic glutamate receptor 8 (mGluR8) was evaluated


Bioorg Med Chem Lett 8: 2849-54 (1999)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens)
BDBM50072170
PNG
((1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl...)
Show SMILES CC(C)C[C@@H]1[C@@H]([C@H]1C(N)(CC1c2ccccc2Oc2ccccc12)C(O)=O)C(O)=O
Show InChI InChI=1S/C24H27NO5/c1-13(2)11-16-20(22(26)27)21(16)24(25,23(28)29)12-17-14-7-3-5-9-18(14)30-19-10-6-4-8-15(17)19/h3-10,13,16-17,20-21H,11-12,25H2,1-2H3,(H,26,27)(H,28,29)/t16-,20+,21+,24?/m1/s1
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n/an/a 380n/an/an/an/an/an/a



Centro de Investigación Lilly, SA

Curated by ChEMBL


Assay Description
Antagonistic activity against metabotropic glutamate receptor 8 (mGluR8) was evaluated


Bioorg Med Chem Lett 8: 2849-54 (1999)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens)
BDBM50072177
PNG
((1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl...)
Show SMILES CCCC[C@@H]1[C@@H]([C@H]1C(N)(CC1c2ccccc2Oc2ccccc12)C(O)=O)C(O)=O
Show InChI InChI=1S/C24H27NO5/c1-2-3-8-16-20(22(26)27)21(16)24(25,23(28)29)13-17-14-9-4-6-11-18(14)30-19-12-7-5-10-15(17)19/h4-7,9-12,16-17,20-21H,2-3,8,13,25H2,1H3,(H,26,27)(H,28,29)/t16-,20+,21+,24?/m1/s1
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n/an/a 490n/an/an/an/an/an/a



Centro de Investigación Lilly, SA

Curated by ChEMBL


Assay Description
Antagonistic activity against metabotropic glutamate receptor 8 (mGluR8) was evaluated


Bioorg Med Chem Lett 8: 2849-54 (1999)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens)
BDBM50072173
PNG
((1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl...)
Show SMILES CCCCCC[C@@H]1[C@@H]([C@H]1C(N)(CC1c2ccccc2Oc2ccccc12)C(O)=O)C(O)=O
Show InChI InChI=1S/C26H31NO5/c1-2-3-4-5-12-18-22(24(28)29)23(18)26(27,25(30)31)15-19-16-10-6-8-13-20(16)32-21-14-9-7-11-17(19)21/h6-11,13-14,18-19,22-23H,2-5,12,15,27H2,1H3,(H,28,29)(H,30,31)/t18-,22+,23+,26?/m1/s1
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n/an/a 750n/an/an/an/an/an/a



Centro de Investigación Lilly, SA

Curated by ChEMBL


Assay Description
Antagonistic activity against metabotropic glutamate receptor 8 (mGluR8) was evaluated


Bioorg Med Chem Lett 8: 2849-54 (1999)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens)
BDBM50072176
PNG
((1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl...)
Show SMILES NC(CC1c2ccccc2Oc2ccccc12)([C@H]1[C@H](CCc2ccccc2)[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C28H27NO5/c29-28(27(32)33,25-20(24(25)26(30)31)15-14-17-8-2-1-3-9-17)16-21-18-10-4-6-12-22(18)34-23-13-7-5-11-19(21)23/h1-13,20-21,24-25H,14-16,29H2,(H,30,31)(H,32,33)/t20-,24+,25+,28?/m1/s1
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n/an/a 990n/an/an/an/an/an/a



Centro de Investigación Lilly, SA

Curated by ChEMBL


Assay Description
Antagonistic activity against metabotropic glutamate receptor 8 (mGluR8) was evaluated


Bioorg Med Chem Lett 8: 2849-54 (1999)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens)
BDBM50072171
PNG
((1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl...)
Show SMILES C[C@@H]1[C@@H]([C@H]1C(N)(CC1c2ccccc2Oc2ccccc12)C(O)=O)C(O)=O
Show InChI InChI=1S/C21H21NO5/c1-11-17(19(23)24)18(11)21(22,20(25)26)10-14-12-6-2-4-8-15(12)27-16-9-5-3-7-13(14)16/h2-9,11,14,17-18H,10,22H2,1H3,(H,23,24)(H,25,26)/t11-,17+,18+,21?/m1/s1
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n/an/a 1.23E+3n/an/an/an/an/an/a



Centro de Investigación Lilly, SA

Curated by ChEMBL


Assay Description
Antagonistic activity against metabotropic glutamate receptor 8 (mGluR8) was evaluated


Bioorg Med Chem Lett 8: 2849-54 (1999)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens)
BDBM50072168
PNG
((1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl...)
Show SMILES CCC[C@@H]1[C@@H]([C@H]1C(N)(CC1c2ccccc2Oc2ccccc12)C(O)=O)C(O)=O
Show InChI InChI=1S/C23H25NO5/c1-2-7-15-19(21(25)26)20(15)23(24,22(27)28)12-16-13-8-3-5-10-17(13)29-18-11-6-4-9-14(16)18/h3-6,8-11,15-16,19-20H,2,7,12,24H2,1H3,(H,25,26)(H,27,28)/t15-,19+,20+,23?/m1/s1
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n/an/a 2.25E+3n/an/an/an/an/an/a



Centro de Investigación Lilly, SA

Curated by ChEMBL


Assay Description
Antagonistic activity against metabotropic glutamate receptor 8 (mGluR8) was evaluated


Bioorg Med Chem Lett 8: 2849-54 (1999)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens)
BDBM50072172
PNG
((1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl...)
Show SMILES CC[C@@H]1[C@@H]([C@H]1C(N)(CC1c2ccccc2Oc2ccccc12)C(O)=O)C(O)=O
Show InChI InChI=1S/C22H23NO5/c1-2-12-18(20(24)25)19(12)22(23,21(26)27)11-15-13-7-3-5-9-16(13)28-17-10-6-4-8-14(15)17/h3-10,12,15,18-19H,2,11,23H2,1H3,(H,24,25)(H,26,27)/t12-,18+,19+,22?/m1/s1
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n/an/a 2.52E+3n/an/an/an/an/an/a



Centro de Investigación Lilly, SA

Curated by ChEMBL


Assay Description
Antagonistic activity against metabotropic glutamate receptor 8 (mGluR8) was evaluated


Bioorg Med Chem Lett 8: 2849-54 (1999)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8 (mGlu8)


(Rattus norvegicus (Rat))
BDBM50372868
PNG
(CHEMBL404886)
Show SMILES Oc1cc2N=C(CC(=O)Nc2cc1C#Cc1ccc(F)cc1)c1cccc(c1)-n1ccnn1
Show InChI InChI=1S/C25H16FN5O2/c26-19-8-5-16(6-9-19)4-7-18-13-22-23(14-24(18)32)28-21(15-25(33)29-22)17-2-1-3-20(12-17)31-11-10-27-30-31/h1-3,5-6,8-14,32H,15H2,(H,29,33)
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n/an/a 5.00E+3n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]-L-AP4 from rat mGluR8


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens)
BDBM50072174
PNG
((1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl...)
Show SMILES CCCCCCCCC[C@@H]1[C@@H]([C@H]1C(N)(CC1c2ccccc2Oc2ccccc12)C(O)=O)C(O)=O
Show InChI InChI=1S/C29H37NO5/c1-2-3-4-5-6-7-8-15-21-25(27(31)32)26(21)29(30,28(33)34)18-22-19-13-9-11-16-23(19)35-24-17-12-10-14-20(22)24/h9-14,16-17,21-22,25-26H,2-8,15,18,30H2,1H3,(H,31,32)(H,33,34)/t21-,25+,26+,29?/m1/s1
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n/an/a 5.18E+3n/an/an/an/an/an/a



Centro de Investigación Lilly, SA

Curated by ChEMBL


Assay Description
Antagonistic activity against metabotropic glutamate receptor 8 (mGluR8) was evaluated


Bioorg Med Chem Lett 8: 2849-54 (1999)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens)
BDBM50278924
PNG
(CHEMBL505105 | N-methyl-5-(phenylethynyl)pyrimidin...)
Show SMILES CNc1ncc(cn1)C#Cc1ccccc1
Show InChI InChI=1S/C13H11N3/c1-14-13-15-9-12(10-16-13)8-7-11-5-3-2-4-6-11/h2-6,9-10H,1H3,(H,14,15,16)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at mGlu8 receptor


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens)
BDBM50301804
PNG
(5-(1-(2,4-difluorophenyl)-5-methyl-1H-1,2,3-triazo...)
Show SMILES CC(C)N1Cc2cc(ccc2C1=O)-c1nnn(c1C)-c1ccc(F)cc1F
Show InChI InChI=1S/C20H18F2N4O/c1-11(2)25-10-14-8-13(4-6-16(14)20(25)27)19-12(3)26(24-23-19)18-7-5-15(21)9-17(18)22/h4-9,11H,10H2,1-3H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human mGluR8 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens)
BDBM50301520
PNG
(4-fluoro-N-(4-(6-(isopropylamino)pyrimidin-4-yl)th...)
Show SMILES CC(C)Nc1cc(ncn1)-c1csc(n1)N(C)C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C18H18FN5OS/c1-11(2)22-16-8-14(20-10-21-16)15-9-26-18(23-15)24(3)17(25)12-4-6-13(19)7-5-12/h4-11H,1-3H3,(H,20,21,22)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human mGluR8 receptor


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens)
BDBM50278930
PNG
(2-(m-tolylethynyl)pyrimidine | CHEMBL496882)
Show SMILES Cc1cccc(c1)C#Cc1ncccn1
Show InChI InChI=1S/C13H10N2/c1-11-4-2-5-12(10-11)6-7-13-14-8-3-9-15-13/h2-5,8-10H,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at mGlu8 receptor


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens)
BDBM50121643
PNG
(CHEMBL3616847)
Show SMILES N[C@]1(C[C@@H](Sc2nnc[nH]2)[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Show InChI InChI=1/C10H12N4O4S/c11-10(8(17)18)1-3(19-9-12-2-13-14-9)4-5(6(4)10)7(15)16/h2-6H,1,11H2,(H,15,16)(H,17,18)(H,12,13,14)/t3-,4+,5+,6+,10+/s2
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n/an/a>1.25E+4n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant mGlu8 receptor expressed in AV12 cells assessed as inhibition of glutamate-stimulated Ca2+ mobilization afte...


J Med Chem 58: 7526-48 (2015)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens)
BDBM50339075
PNG
(Adamantan-1-yl-(4-pyridin-2-yl-piperazin-1-yl)-met...)
Show SMILES O=C(N1CCN(CC1)c1nccs1)C12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C18H25N3OS/c22-16(18-10-13-7-14(11-18)9-15(8-13)12-18)20-2-4-21(5-3-20)17-19-1-6-23-17/h1,6,13-15H,2-5,7-12H2
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n/an/a>3.00E+4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of mGluR8


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens)
BDBM50346073
PNG
(CHEMBL1783985 | cyclobutyl(2-azaspiro[5.5]undecan-...)
Show SMILES O=C(C1CCC1)N1CCCC2(CCCCC2)C1
Show InChI InChI=1S/C15H25NO/c17-14(13-6-4-7-13)16-11-5-10-15(12-16)8-2-1-3-9-15/h13H,1-12H2
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n/an/a>3.00E+4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of mGluR8


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens)
BDBM50116512
PNG
(CHEMBL3609741)
Show SMILES FCOc1cc(NC(=O)c2ccccn2)ccc1Cl
Show InChI InChI=1S/C13H10ClFN2O2/c14-10-5-4-9(7-12(10)19-8-15)17-13(18)11-3-1-2-6-16-11/h1-7H,8H2,(H,17,18)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Activity at mGlu8 receptor (unknown origin) expressed in HEK293 cells pre-treated for 15 mins before addition of EC80 concentration of reference agon...


Bioorg Med Chem Lett 25: 3956-60 (2015)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens)
BDBM50071165
PNG
((2R,4R)-4-Amino-1-(2-chloro-benzyl)-pyrrolidine-2,...)
Show SMILES N[C@@]1(C[C@@H](N(Cc2ccccc2Cl)C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C13H15ClN2O4/c14-9-4-2-1-3-8(9)6-16-7-13(15,12(19)20)5-10(16)11(17)18/h1-4,10H,5-7,15H2,(H,17,18)(H,19,20)/t10-,13-/m1/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
In vitro antagonist activity at recombinant Metabotropic glutamate receptor 8 expressed in RGT cells.


Bioorg Med Chem Lett 8: 1985-90 (1999)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens)
BDBM50071150
PNG
((2R,4R)-4-Amino-1-biphenyl-2-ylmethyl-pyrrolidine-...)
Show SMILES N[C@@]1(C[C@@H](N(Cc2ccccc2-c2ccccc2)C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C19H20N2O4/c20-19(18(24)25)10-16(17(22)23)21(12-19)11-14-8-4-5-9-15(14)13-6-2-1-3-7-13/h1-9,16H,10-12,20H2,(H,22,23)(H,24,25)/t16-,19-/m1/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
In vitro antagonist activity at recombinant Metabotropic glutamate receptor 8 expressed in RGT cells.


Bioorg Med Chem Lett 8: 1985-90 (1999)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens)
BDBM50071164
PNG
((2R,4R)-4-Amino-1-methyl-pyrrolidine-2,4-dicarboxy...)
Show SMILES CN1C[C@](N)(C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C7H12N2O4/c1-9-3-7(8,6(12)13)2-4(9)5(10)11/h4H,2-3,8H2,1H3,(H,10,11)(H,12,13)/t4-,7-/m1/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
In vitro antagonist activity at recombinant Metabotropic glutamate receptor 8 expressed in RGT cells.


Bioorg Med Chem Lett 8: 1985-90 (1999)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens)
BDBM50049748
PNG
((2S,4S)-2-Amino-4-(4,4-diphenyl-butyl)-pentanedioi...)
Show SMILES N[C@@H](C[C@H](CCCC(c1ccccc1)c1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C21H25NO4/c22-19(21(25)26)14-17(20(23)24)12-7-13-18(15-8-3-1-4-9-15)16-10-5-2-6-11-16/h1-6,8-11,17-19H,7,12-14,22H2,(H,23,24)(H,25,26)/t17-,19-/m0/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
In vitro antagonist activity at recombinant Metabotropic glutamate receptor 8 expressed in RGT cells.


Bioorg Med Chem Lett 8: 1985-90 (1999)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens)
BDBM50071167
PNG
((2R,4R)-4-Amino-1-(2,6-dichloro-benzyl)-pyrrolidin...)
Show SMILES N[C@@]1(C[C@@H](N(Cc2c(Cl)cccc2Cl)C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C13H14Cl2N2O4/c14-8-2-1-3-9(15)7(8)5-17-6-13(16,12(20)21)4-10(17)11(18)19/h1-3,10H,4-6,16H2,(H,18,19)(H,20,21)/t10-,13-/m1/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
In vitro antagonist activity at recombinant Metabotropic glutamate receptor 8 expressed in RGT cells.


Bioorg Med Chem Lett 8: 1985-90 (1999)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens)
BDBM50071151
PNG
((2R,4R)-4-Amino-1-(2,2-diphenyl-ethyl)-pyrrolidine...)
Show SMILES N[C@@]1(C[C@@H](N(CC(c2ccccc2)c2ccccc2)C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C20H22N2O4/c21-20(19(25)26)11-17(18(23)24)22(13-20)12-16(14-7-3-1-4-8-14)15-9-5-2-6-10-15/h1-10,16-17H,11-13,21H2,(H,23,24)(H,25,26)/t17-,20-/m1/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
In vitro antagonist activity at recombinant Metabotropic glutamate receptor 8 expressed in RGT cells.


Bioorg Med Chem Lett 8: 1985-90 (1999)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens)
BDBM50071168
PNG
((2R,4R)-4-Amino-1-(3-chloro-benzyl)-pyrrolidine-2,...)
Show SMILES N[C@@]1(C[C@@H](N(Cc2cccc(Cl)c2)C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C13H15ClN2O4/c14-9-3-1-2-8(4-9)6-16-7-13(15,12(19)20)5-10(16)11(17)18/h1-4,10H,5-7,15H2,(H,17,18)(H,19,20)/t10-,13-/m1/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
In vitro antagonist activity at recombinant Metabotropic glutamate receptor 8 expressed in RGT cells.


Bioorg Med Chem Lett 8: 1985-90 (1999)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens)
BDBM50071159
PNG
((2R,4R)-4-Amino-1-naphthalen-1-ylmethyl-pyrrolidin...)
Show SMILES N[C@@]1(C[C@@H](N(Cc2cccc3ccccc23)C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C17H18N2O4/c18-17(16(22)23)8-14(15(20)21)19(10-17)9-12-6-3-5-11-4-1-2-7-13(11)12/h1-7,14H,8-10,18H2,(H,20,21)(H,22,23)/t14-,17-/m1/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
In vitro antagonist activity at recombinant Metabotropic glutamate receptor 8 expressed in RGT cells.


Bioorg Med Chem Lett 8: 1985-90 (1999)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens)
BDBM50071161
PNG
((2R,4R)-4-Amino-1-benzyl-pyrrolidine-2,4-dicarboxy...)
Show SMILES N[C@@]1(C[C@@H](N(Cc2ccccc2)C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C13H16N2O4/c14-13(12(18)19)6-10(11(16)17)15(8-13)7-9-4-2-1-3-5-9/h1-5,10H,6-8,14H2,(H,16,17)(H,18,19)/t10-,13-/m1/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
In vitro antagonist activity at recombinant Metabotropic glutamate receptor 8 expressed in RGT cells.


Bioorg Med Chem Lett 8: 1985-90 (1999)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens)
BDBM50071155
PNG
((2R,4R)-4-Amino-1-naphthalen-2-ylmethyl-pyrrolidin...)
Show SMILES N[C@@]1(C[C@@H](N(Cc2ccc3ccccc3c2)C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C17H18N2O4/c18-17(16(22)23)8-14(15(20)21)19(10-17)9-11-5-6-12-3-1-2-4-13(12)7-11/h1-7,14H,8-10,18H2,(H,20,21)(H,22,23)/t14-,17-/m1/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
In vitro antagonist activity at recombinant Metabotropic glutamate receptor 8 expressed in RGT cells.


Bioorg Med Chem Lett 8: 1985-90 (1999)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens)
BDBM50071156
PNG
((2R,4R)-4-Amino-1-ethyl-pyrrolidine-2,4-dicarboxyl...)
Show SMILES CCN1C[C@](N)(C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C8H14N2O4/c1-2-10-4-8(9,7(13)14)3-5(10)6(11)12/h5H,2-4,9H2,1H3,(H,11,12)(H,13,14)/t5-,8-/m1/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
In vitro antagonist activity at recombinant Metabotropic glutamate receptor 8 expressed in RGT cells.


Bioorg Med Chem Lett 8: 1985-90 (1999)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens)
BDBM50069111
PNG
((2S,4S)-2-Amino-4-(2,2-diphenyl-ethyl)-pentanedioi...)
Show SMILES N[C@@H](C[C@H](CC(c1ccccc1)c1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C19H21NO4/c20-17(19(23)24)12-15(18(21)22)11-16(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10,15-17H,11-12,20H2,(H,21,22)(H,23,24)/t15-,17-/m0/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



Centro de Investigación Lilly

Curated by ChEMBL


Assay Description
Tested for agonist activity in non-neuronal cells (RGT) expressing human Metabotropic glutamate receptor 8 by measuring L-AP4 (0.3 uM of forskolin) (...


Bioorg Med Chem Lett 8: 765-70 (1999)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens)
BDBM50049748
PNG
((2S,4S)-2-Amino-4-(4,4-diphenyl-butyl)-pentanedioi...)
Show SMILES N[C@@H](C[C@H](CCCC(c1ccccc1)c1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C21H25NO4/c22-19(21(25)26)14-17(20(23)24)12-7-13-18(15-8-3-1-4-9-15)16-10-5-2-6-11-16/h1-6,8-11,17-19H,7,12-14,22H2,(H,23,24)(H,25,26)/t17-,19-/m0/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



Centro de Investigación Lilly

Curated by ChEMBL


Assay Description
Tested for agonist activity in non-neuronal cells (RGT) expressing human Metabotropic glutamate receptor 8 by measuring L-AP4 (0.3 uM of forskolin) (...


Bioorg Med Chem Lett 8: 765-70 (1999)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens)
BDBM50071162
PNG
(4-((S)-1-Carboxy-ethylamino)-benzoic acid | CHEMBL...)
Show SMILES C[C@H](Nc1ccc(cc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C10H11NO4/c1-6(9(12)13)11-8-4-2-7(3-5-8)10(14)15/h2-6,11H,1H3,(H,12,13)(H,14,15)/t6-/m0/s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
In vitro antagonist activity at recombinant Metabotropic glutamate receptor 8 expressed in RGT cells.


Bioorg Med Chem Lett 8: 1985-90 (1999)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens)
BDBM50007548
PNG
((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...)
Show SMILES N[C@@H](CCP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1
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61n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist potency against cloned Metabotropic glutamate receptor 8 (mGluR-8).


J Med Chem 43: 2609-45 (2000)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens)
BDBM50062522
PNG
((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)
Show SMILES N[C@@](CC1c2ccccc2Oc2ccccc12)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C20H19NO5/c21-20(19(24)25,15-9-13(15)18(22)23)10-14-11-5-1-3-7-16(11)26-17-8-4-2-6-12(14)17/h1-8,13-15H,9-10,21H2,(H,22,23)(H,24,25)/t13-,15-,20-/m0/s1
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170n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist potency against cloned Metabotropic glutamate receptor 8 (mGluR-8).


J Med Chem 43: 2609-45 (2000)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens)
BDBM50004881
PNG
((RS) PPG | Amino-(4-phosphono-phenyl)-acetic acid ...)
Show SMILES NC(C(O)=O)c1ccc(cc1)P(O)(O)=O
Show InChI InChI=1S/C8H10NO5P/c9-7(8(10)11)5-1-3-6(4-2-5)15(12,13)14/h1-4,7H,9H2,(H,10,11)(H2,12,13,14)
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210n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist potency against cloned Metabotropic glutamate receptor 8 (mGluR-8).


J Med Chem 43: 2609-45 (2000)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8 (mGlu8)


(Rattus norvegicus (Rat))
BDBM50089910
PNG
(2-Amino-2-(4-phosphono-phenyl)-propionic acid | 2-...)
Show SMILES CC(N)(C(O)=O)c1ccc(cc1)P(O)(O)=O
Show InChI InChI=1S/C9H12NO5P/c1-9(10,8(11)12)6-2-4-7(5-3-6)16(13,14)15/h2-5H,10H2,1H3,(H,11,12)(H2,13,14,15)
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480n/an/an/an/an/an/an/an/a



University of Toronto

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8 (mGlu8)


(Rattus norvegicus (Rat))
BDBM17664
PNG
((2S)-2-amino-3-(phosphonooxy)propanoic acid | CHEM...)
Show SMILES N[C@@H](COP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1
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1.20E+3n/an/an/an/an/an/an/an/a



University of Toronto

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8 (mGlu8)


(Rattus norvegicus (Rat))
BDBM50004051
PNG
(2-Amino-4-phosphono-butyric acid | 2-Amino-4-phosp...)
Show SMILES NC(CCP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)
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1.26E+3n/an/an/an/an/an/an/an/a



Case Western Reserve University

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8 (mGlu8)


(Rattus norvegicus (Rat))
BDBM50004881
PNG
((RS) PPG | Amino-(4-phosphono-phenyl)-acetic acid ...)
Show SMILES NC(C(O)=O)c1ccc(cc1)P(O)(O)=O
Show InChI InChI=1S/C8H10NO5P/c9-7(8(10)11)5-1-3-6(4-2-5)15(12,13)14/h1-4,7H,9H2,(H,10,11)(H2,12,13,14)
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1.30E+3n/an/an/an/an/an/an/an/a



University of Toronto

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens)
BDBM50089890
PNG
(4-Amino-2-oxa-bicyclo[3.1.0]hexane-4,6-dicarboxyli...)
Show SMILES N[C@]1(COC2[C@@H](C12)C(O)=O)C(O)=O
Show InChI InChI=1S/C7H9NO5/c8-7(6(11)12)1-13-4-2(3(4)7)5(9)10/h2-4H,1,8H2,(H,9,10)(H,11,12)/t2-,3?,4?,7+/m1/s1
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1.70E+3n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist potency against cloned Metabotropic glutamate receptor 8 (mGluR-8).


J Med Chem 43: 2609-45 (2000)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8 (mGlu8)


(Rattus norvegicus (Rat))
BDBM50007548
PNG
((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...)
Show SMILES N[C@@H](CCP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1
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1.90E+3n/an/an/an/an/an/an/an/a



Universit£ di Perugia

Curated by ChEMBL


Assay Description
Displacement of [3H]LY341495 from rat recombinant mGluR8 expressed in BHK cells by SPA assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8 (mGlu8)


(Rattus norvegicus (Rat))
BDBM50007548
PNG
((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...)
Show SMILES N[C@@H](CCP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1
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1.90E+3n/an/an/an/an/an/an/an/a



Universit£ di Perugia

Curated by ChEMBL


Assay Description
Displacement of [3H]LY341495 from rat mGluR8 expressed in BHK cells


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8 (mGlu8)


(Rattus norvegicus (Rat))
BDBM50007548
PNG
((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...)
Show SMILES N[C@@H](CCP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1
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2.70E+3n/an/an/an/an/an/an/an/a



University of Toronto

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens)
BDBM50034504
PNG
((1S,2S)-2-((S)-Amino-carboxy-methyl)-cyclopropanec...)
Show SMILES N[C@@H]([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C6H9NO4/c7-4(6(10)11)2-1-3(2)5(8)9/h2-4H,1,7H2,(H,8,9)(H,10,11)/t2-,3-,4-/m0/s1
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3.40E+3n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist potency against cloned Metabotropic glutamate receptor 8 (mGluR-8).


J Med Chem 43: 2609-45 (2000)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8 (mGlu8)


(Rattus norvegicus (Rat))
BDBM17657
PNG
((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Show SMILES N[C@@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
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3.40E+3n/an/an/an/an/an/an/an/a



Universit£ di Perugia

Curated by ChEMBL


Assay Description
Displacement of [3H]LY341495 from rat recombinant mGluR8 expressed in BHK cells by SPA assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8 (mGlu8)


(Rattus norvegicus (Rat))
BDBM17657
PNG
((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Show SMILES N[C@@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
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3.40E+3n/an/an/an/an/an/an/an/a



Universit£ di Perugia

Curated by ChEMBL


Assay Description
Displacement of [3H]LY341495 from rat mGluR8 expressed in BHK cells


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens)
BDBM50089897
PNG
(4-Amino-2-thia-bicyclo[3.1.0]hexane-4,6-dicarboxyl...)
Show SMILES N[C@]1(CSC2[C@@H](C12)C(O)=O)C(O)=O
Show InChI InChI=1S/C7H9NO4S/c8-7(6(11)12)1-13-4-2(3(4)7)5(9)10/h2-4H,1,8H2,(H,9,10)(H,11,12)/t2-,3?,4?,7+/m1/s1
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7.30E+3n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist potency against cloned Metabotropic glutamate receptor 8 (mGluR-8).


J Med Chem 43: 2609-45 (2000)

More data for this
Ligand-Target Pair
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