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Compile Data Set for Download or QSAR

Found 303 hits Enz. Inhib. hit(s) with Target = 'Methionine Aminopeptidase Type 1 (MetAP1)'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50435227
PNG
(CHEMBL2392772)
Show SMILES Cc1nc(nc(NC2CCN(CC2)c2ncc(cc2Cl)C(F)(F)F)c1Cl)-c1ccccn1
Show InChI InChI=1S/C21H19Cl2F3N6/c1-12-17(23)19(31-18(29-12)16-4-2-3-7-27-16)30-14-5-8-32(9-6-14)20-15(22)10-13(11-28-20)21(24,25)26/h2-4,7,10-11,14H,5-6,8-9H2,1H3,(H,29,30,31)
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n/an/a 360n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...


Bioorg Med Chem 21: 2600-17 (2013)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM17589
PNG
((2S,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxy-N-[(1S...)
Show SMILES CCSCC[C@@H](N)[C@H](O)C(=O)N[C@@H](C)c1cccc2ccccc12
Show InChI InChI=1S/C19H26N2O2S/c1-3-24-12-11-17(20)18(22)19(23)21-13(2)15-10-6-8-14-7-4-5-9-16(14)15/h4-10,13,17-18,22H,3,11-12,20H2,1-2H3,(H,21,23)/t13-,17+,18-/m0/s1
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PubMed
n/an/a 370n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase activity by monitoring the production of free methionine with L...


Cancer Res 63: 7861-9 (2003)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM17589
PNG
((2S,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxy-N-[(1S...)
Show SMILES CCSCC[C@@H](N)[C@H](O)C(=O)N[C@@H](C)c1cccc2ccccc12
Show InChI InChI=1S/C19H26N2O2S/c1-3-24-12-11-17(20)18(22)19(23)21-13(2)15-10-6-8-14-7-4-5-9-16(14)15/h4-10,13,17-18,22H,3,11-12,20H2,1-2H3,(H,21,23)/t13-,17+,18-/m0/s1
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n/an/a 370n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against human methionine aminopeptidase-1


Bioorg Med Chem Lett 14: 865-8 (2004)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50435217
PNG
(CHEMBL2392900)
Show SMILES Cc1nc(nc(NC[C@H](NS(=O)(=O)CCN2CCN(CCO)CC2)c2ccccc2)c1Cl)-c1ccccn1
Show InChI InChI=1S/C26H34ClN7O3S/c1-20-24(27)26(31-25(30-20)22-9-5-6-10-28-22)29-19-23(21-7-3-2-4-8-21)32-38(36,37)18-16-34-13-11-33(12-14-34)15-17-35/h2-10,23,32,35H,11-19H2,1H3,(H,29,30,31)/t23-/m0/s1
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n/an/a 600n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...


Bioorg Med Chem 21: 2600-17 (2013)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50435224
PNG
(CHEMBL2392893)
Show SMILES Cc1nc(nc(NC[C@H](NC(=O)CCN2CCNCC2)c2ccccc2)c1Cl)-c1ccccn1
Show InChI InChI=1S/C25H30ClN7O/c1-18-23(26)25(32-24(30-18)20-9-5-6-11-28-20)29-17-21(19-7-3-2-4-8-19)31-22(34)10-14-33-15-12-27-13-16-33/h2-9,11,21,27H,10,12-17H2,1H3,(H,31,34)(H,29,30,32)/t21-/m0/s1
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n/an/a 600n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...


Bioorg Med Chem 21: 2600-17 (2013)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50435226
PNG
(CHEMBL2392891)
Show SMILES Cc1nc(nc(NC[C@H](NC(=O)CCN2CCN(CCO)CC2)c2ccccc2)c1Cl)-c1ccccn1
Show InChI InChI=1S/C27H34ClN7O2/c1-20-25(28)27(33-26(31-20)22-9-5-6-11-29-22)30-19-23(21-7-3-2-4-8-21)32-24(37)10-12-34-13-15-35(16-14-34)17-18-36/h2-9,11,23,36H,10,12-19H2,1H3,(H,32,37)(H,30,31,33)/t23-/m0/s1
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n/an/a 800n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...


Bioorg Med Chem 21: 2600-17 (2013)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50435219
PNG
(CHEMBL2392898)
Show SMILES Cc1nc(nc(NC[C@H](NCCCCN2CCN(CCO)CC2)c2ccccc2)c1Cl)-c1ccccn1
Show InChI InChI=1S/C28H38ClN7O/c1-22-26(29)28(34-27(33-22)24-11-5-6-12-30-24)32-21-25(23-9-3-2-4-10-23)31-13-7-8-14-35-15-17-36(18-16-35)19-20-37/h2-6,9-12,25,31,37H,7-8,13-21H2,1H3,(H,32,33,34)/t25-/m0/s1
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n/an/a 800n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...


Bioorg Med Chem 21: 2600-17 (2013)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50435218
PNG
(CHEMBL2392899)
Show SMILES Cc1nc(nc(NC[C@H](NS(=O)(=O)CCN2CCNCC2)c2ccccc2)c1Cl)-c1ccccn1
Show InChI InChI=1S/C24H30ClN7O2S/c1-18-22(25)24(30-23(29-18)20-9-5-6-10-27-20)28-17-21(19-7-3-2-4-8-19)31-35(33,34)16-15-32-13-11-26-12-14-32/h2-10,21,26,31H,11-17H2,1H3,(H,28,29,30)/t21-/m0/s1
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n/an/a 800n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...


Bioorg Med Chem 21: 2600-17 (2013)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50433375
PNG
(CHEMBL472879 | GNF-Pf-359)
Show SMILES Cc1nc(nc(NCCc2ccccc2)c1Cl)-c1ccccn1
Show InChI InChI=1S/C18H17ClN4/c1-13-16(19)18(21-12-10-14-7-3-2-4-8-14)23-17(22-13)15-9-5-6-11-20-15/h2-9,11H,10,12H2,1H3,(H,21,22,23)
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n/an/a 860n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...


Bioorg Med Chem 21: 2600-17 (2013)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50435229
PNG
(CHEMBL2392771)
Show SMILES Cc1nc(nc(NCCNc2cccc(n2)C(F)(F)F)c1Cl)-c1ccccn1
Show InChI InChI=1S/C18H16ClF3N6/c1-11-15(19)17(28-16(26-11)12-5-2-3-8-23-12)25-10-9-24-14-7-4-6-13(27-14)18(20,21)22/h2-8H,9-10H2,1H3,(H,24,27)(H,25,26,28)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...


Bioorg Med Chem 21: 2600-17 (2013)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50435223
PNG
(CHEMBL2392894)
Show SMILES Cc1nc(nc(NC[C@H](NC(=O)CCCN2CCNCC2)c2ccccc2)c1Cl)-c1ccccn1
Show InChI InChI=1S/C26H32ClN7O/c1-19-24(27)26(33-25(31-19)21-10-5-6-12-29-21)30-18-22(20-8-3-2-4-9-20)32-23(35)11-7-15-34-16-13-28-14-17-34/h2-6,8-10,12,22,28H,7,11,13-18H2,1H3,(H,32,35)(H,30,31,33)/t22-/m0/s1
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n/an/a 1.10E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...


Bioorg Med Chem 21: 2600-17 (2013)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50435225
PNG
(CHEMBL2392892)
Show SMILES Cc1nc(nc(NC[C@H](NC(=O)CCCN2CCN(CCO)CC2)c2ccccc2)c1Cl)-c1ccccn1
Show InChI InChI=1S/C28H36ClN7O2/c1-21-26(29)28(34-27(32-21)23-10-5-6-12-30-23)31-20-24(22-8-3-2-4-9-22)33-25(38)11-7-13-35-14-16-36(17-15-35)18-19-37/h2-6,8-10,12,24,37H,7,11,13-20H2,1H3,(H,33,38)(H,31,32,34)/t24-/m0/s1
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n/an/a 1.10E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...


Bioorg Med Chem 21: 2600-17 (2013)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50435228
PNG
(CHEMBL460432)
Show SMILES Cc1nc(nc(N2CCN(CCO)CC2)c1Cl)-c1ccccn1
Show InChI InChI=1S/C16H20ClN5O/c1-12-14(17)16(22-8-6-21(7-9-22)10-11-23)20-15(19-12)13-4-2-3-5-18-13/h2-5,23H,6-11H2,1H3
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n/an/a 1.10E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...


Bioorg Med Chem 21: 2600-17 (2013)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50141691
PNG
((1S,2R)-3-Amino-5-ethylsulfanyl-2-hydroxy-pentanoi...)
Show SMILES CCSCC[C@@H](N)[C@H](O)C(=O)NNc1ccc(C)cc1
Show InChI InChI=1S/C14H23N3O2S/c1-3-20-9-8-12(15)13(18)14(19)17-16-11-6-4-10(2)5-7-11/h4-7,12-13,16,18H,3,8-9,15H2,1-2H3,(H,17,19)/t12-,13+/m1/s1
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n/an/a 1.30E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against human methionine aminopeptidase-1


Bioorg Med Chem Lett 14: 865-8 (2004)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50435220
PNG
(CHEMBL2392897)
Show SMILES Cc1nc(nc(NC[C@H](NCCCCN2CCNCC2)c2ccccc2)c1Cl)-c1ccccn1
Show InChI InChI=1S/C26H34ClN7/c1-20-24(27)26(33-25(32-20)22-11-5-6-12-29-22)31-19-23(21-9-3-2-4-10-21)30-13-7-8-16-34-17-14-28-15-18-34/h2-6,9-12,23,28,30H,7-8,13-19H2,1H3,(H,31,32,33)/t23-/m0/s1
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n/an/a 1.30E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...


Bioorg Med Chem 21: 2600-17 (2013)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50141738
PNG
((2S,3R)-3-Amino-5-ethylsulfanyl-2-hydroxy-pentanoi...)
Show SMILES CCSCC[C@@H](N)[C@H](O)C(=O)NOc1ccccc1
Show InChI InChI=1S/C13H20N2O3S/c1-2-19-9-8-11(14)12(16)13(17)15-18-10-6-4-3-5-7-10/h3-7,11-12,16H,2,8-9,14H2,1H3,(H,15,17)/t11-,12+/m1/s1
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n/an/a 1.30E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against human methionine aminopeptidase-1


Bioorg Med Chem Lett 14: 865-8 (2004)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50435222
PNG
(CHEMBL2392895)
Show SMILES Cc1nc(nc(NC[C@H](NCCCN2CCNCC2)c2ccccc2)c1Cl)-c1ccccn1
Show InChI InChI=1S/C25H32ClN7/c1-19-23(26)25(32-24(31-19)21-10-5-6-11-28-21)30-18-22(20-8-3-2-4-9-20)29-12-7-15-33-16-13-27-14-17-33/h2-6,8-11,22,27,29H,7,12-18H2,1H3,(H,30,31,32)/t22-/m0/s1
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n/an/a 1.40E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...


Bioorg Med Chem 21: 2600-17 (2013)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50435231
PNG
(CHEMBL2392769)
Show SMILES CN(Cc1ccccc1)c1nc(nc(C)c1Cl)-c1ccccn1
Show InChI InChI=1S/C18H17ClN4/c1-13-16(19)18(23(2)12-14-8-4-3-5-9-14)22-17(21-13)15-10-6-7-11-20-15/h3-11H,12H2,1-2H3
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n/an/a 1.50E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...


Bioorg Med Chem 21: 2600-17 (2013)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50141693
PNG
((S)-3-Amino-2-hydroxy-4-isobutylsulfanyl-N-phenoxy...)
Show SMILES CC(C)CSC[C@@H](N)[C@H](O)C(=O)NOc1ccccc1
Show InChI InChI=1S/C14H22N2O3S/c1-10(2)8-20-9-12(15)13(17)14(18)16-19-11-6-4-3-5-7-11/h3-7,10,12-13,17H,8-9,15H2,1-2H3,(H,16,18)/t12-,13+/m1/s1
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n/an/a 1.50E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against human methionine aminopeptidase-1


Bioorg Med Chem Lett 14: 865-8 (2004)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM17847
PNG
(CHEMBL327579 | pyridine-2-carboxylic acid inhibito...)
Show SMILES CC(C)(C)OC(=O)Nc1cccnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C14H16N4O3S/c1-14(2,3)21-13(20)17-9-5-4-6-15-10(9)11(19)18-12-16-7-8-22-12/h4-8H,1-3H3,(H,17,20)(H,16,18,19)
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n/an/a 1.50E+3n/an/an/an/a7.522



Johns Hopkins University



Assay Description
The MetAP reaction with Co2+ as a cofactor is coupled to a prolyl aminopeptidase (ProAP) using Met-Pro-p-nitroanilide as substrate. MetAP-catalyzed c...


Proc Natl Acad Sci U S A 103: 18148-53 (2006)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50141746
PNG
((S)-3-Amino-2-hydroxy-N-((S)-1-naphthalen-1-yl-eth...)
Show SMILES CCCSC[C@@H](N)[C@H](O)C(=O)N[C@@H](C)c1cccc2ccccc12
Show InChI InChI=1S/C19H26N2O2S/c1-3-11-24-12-17(20)18(22)19(23)21-13(2)15-10-6-8-14-7-4-5-9-16(14)15/h4-10,13,17-18,22H,3,11-12,20H2,1-2H3,(H,21,23)/t13-,17+,18-/m0/s1
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n/an/a 1.60E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against human methionine aminopeptidase-1


Bioorg Med Chem Lett 14: 865-8 (2004)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50141713
PNG
((S)-3-Amino-2-hydroxy-N-phenoxy-4-propylsulfanyl-b...)
Show SMILES CCCSC[C@@H](N)[C@H](O)C(=O)NOc1ccccc1
Show InChI InChI=1S/C13H20N2O3S/c1-2-8-19-9-11(14)12(16)13(17)15-18-10-6-4-3-5-7-10/h3-7,11-12,16H,2,8-9,14H2,1H3,(H,15,17)/t11-,12+/m1/s1
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n/an/a 1.70E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against human methionine aminopeptidase-1


Bioorg Med Chem Lett 14: 865-8 (2004)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50435221
PNG
(CHEMBL2392896)
Show SMILES Cc1nc(nc(NC[C@H](NCCCN2CCN(CCO)CC2)c2ccccc2)c1Cl)-c1ccccn1
Show InChI InChI=1S/C27H36ClN7O/c1-21-25(28)27(33-26(32-21)23-10-5-6-11-29-23)31-20-24(22-8-3-2-4-9-22)30-12-7-13-34-14-16-35(17-15-34)18-19-36/h2-6,8-11,24,30,36H,7,12-20H2,1H3,(H,31,32,33)/t24-/m0/s1
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n/an/a 1.70E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...


Bioorg Med Chem 21: 2600-17 (2013)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM68281
PNG
(Bengamide A)
Show SMILES CCCCCCCCCCCCCOC(=O)C1CCC(NC(=O)[C@H](OC)[C@H](O)[C@@H](O)[C@H](O)\C=C\C(C)C)C(=O)NC1
Show InChI InChI=1S/C31H56N2O8/c1-5-6-7-8-9-10-11-12-13-14-15-20-41-31(39)23-17-18-24(29(37)32-21-23)33-30(38)28(40-4)27(36)26(35)25(34)19-16-22(2)3/h16,19,22-28,34-36H,5-15,17-18,20-21H2,1-4H3,(H,32,37)(H,33,38)/b19-16+/t23?,24?,25-,26+,27-,28-/m1/s1
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n/an/a 1.90E+3n/an/an/an/an/an/a



The Johns Hopkins University



Assay Description
The determined effects of seven bengamide analogs on the enzymatic activity of both recombinated human MetAP1 and MetAP2 in vitro.


Chem Biol 14: 764-74 (2007)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM17847
PNG
(CHEMBL327579 | pyridine-2-carboxylic acid inhibito...)
Show SMILES CC(C)(C)OC(=O)Nc1cccnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C14H16N4O3S/c1-14(2,3)21-13(20)17-9-5-4-6-15-10(9)11(19)18-12-16-7-8-22-12/h4-8H,1-3H3,(H,17,20)(H,16,18,19)
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n/an/a 2.00E+3n/an/an/an/an/an/a



University of California Santa Cruz

Curated by ChEMBL


Assay Description
Inhibition of methionine aminopeptidase 1


J Nat Prod 72: 588-603 (2010)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50295174
PNG
(Bengamide A | CHEMBL256279)
Show SMILES CCCCCCCCCCCCCC(=O)O[C@H]1CC[C@H](NC(=O)[C@H](OC)[C@H](O)[C@@H](O)[C@H](O)\C=C\C(C)C)C(=O)NC1
Show InChI InChI=1S/C31H56N2O8/c1-5-6-7-8-9-10-11-12-13-14-15-16-26(35)41-23-18-19-24(30(38)32-21-23)33-31(39)29(40-4)28(37)27(36)25(34)20-17-22(2)3/h17,20,22-25,27-29,34,36-37H,5-16,18-19,21H2,1-4H3,(H,32,38)(H,33,39)/b20-17+/t23-,24-,25+,27-,28+,29+/m0/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



University of California Santa Cruz

Curated by ChEMBL


Assay Description
Inhibition of methionine aminopeptidase 1


J Nat Prod 72: 588-603 (2010)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50433377
PNG
(CHEMBL2375628)
Show SMILES Cc1nc(nc(NCCNc2ccc(cn2)C(F)(F)F)c1Cl)-c1ccccn1
Show InChI InChI=1S/C18H16ClF3N6/c1-11-15(19)17(28-16(27-11)13-4-2-3-7-23-13)25-9-8-24-14-6-5-12(10-26-14)18(20,21)22/h2-7,10H,8-9H2,1H3,(H,24,26)(H,25,27,28)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...


Bioorg Med Chem 21: 2600-17 (2013)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM17590
PNG
((2S,3S)-3-amino-2-hydroxy-4-[(2-methylpropyl)sulfa...)
Show SMILES CC(C)CSC[C@@H](N)[C@H](O)C(=O)N[C@@H](C)c1cccc2ccccc12
Show InChI InChI=1S/C20H28N2O2S/c1-13(2)11-25-12-18(21)19(23)20(24)22-14(3)16-10-6-8-15-7-4-5-9-17(15)16/h4-10,13-14,18-19,23H,11-12,21H2,1-3H3,(H,22,24)/t14-,18+,19-/m0/s1
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n/an/a 2.20E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against human methionine aminopeptidase-1


Bioorg Med Chem Lett 14: 865-8 (2004)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM17590
PNG
((2S,3S)-3-amino-2-hydroxy-4-[(2-methylpropyl)sulfa...)
Show SMILES CC(C)CSC[C@@H](N)[C@H](O)C(=O)N[C@@H](C)c1cccc2ccccc12
Show InChI InChI=1S/C20H28N2O2S/c1-13(2)11-25-12-18(21)19(23)20(24)22-14(3)16-10-6-8-15-7-4-5-9-17(15)16/h4-10,13-14,18-19,23H,11-12,21H2,1-3H3,(H,22,24)/t14-,18+,19-/m0/s1
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n/an/a 2.20E+3n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase activity by monitoring the production of free methionine with L...


Cancer Res 63: 7861-9 (2003)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM68286
PNG
(Bengamide N | Bengamide O)
Show SMILES CO[C@H]([C@H](O)[C@@H](O)[C@H](O)\C=C\C(C)C)C(=O)NC1CCC(CN(C)C1=O)C(=O)OCCCCCCCCCCC(C)C
Show InChI InChI=1S/C32H58N2O8/c1-22(2)15-13-11-9-7-8-10-12-14-20-42-32(40)24-17-18-25(31(39)34(5)21-24)33-30(38)29(41-6)28(37)27(36)26(35)19-16-23(3)4/h16,19,22-29,35-37H,7-15,17-18,20-21H2,1-6H3,(H,33,38)/b19-16+/t24?,25?,26-,27+,28-,29-/m1/s1
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n/an/a 2.70E+3n/an/an/an/an/an/a



The Johns Hopkins University



Assay Description
The determined effects of seven bengamide analogs on the enzymatic activity of both recombinated human MetAP1 and MetAP2 in vitro.


Chem Biol 14: 764-74 (2007)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM17849
PNG
(3-(2,2-dimethylpropanamido)-N-(1,3-thiazol-2-yl)py...)
Show SMILES CC(C)(C)C(=O)Nc1cccnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C14H16N4O2S/c1-14(2,3)12(20)17-9-5-4-6-15-10(9)11(19)18-13-16-7-8-21-13/h4-8H,1-3H3,(H,17,20)(H,16,18,19)
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n/an/a 2.90E+3n/an/an/an/a7.522



Johns Hopkins University



Assay Description
The MetAP reaction with Co2+ as a cofactor is coupled to a prolyl aminopeptidase (ProAP) using Met-Pro-p-nitroanilide as substrate. MetAP-catalyzed c...


Proc Natl Acad Sci U S A 103: 18148-53 (2006)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50295173
PNG
(Bengamide O | CHEMBL539894)
Show SMILES CCC(C)CCCCCCCCCCC(=O)O[C@H]1CC[C@H](NC(=O)[C@H](OC)[C@H](O)[C@@H](O)[C@H](O)\C=C\C(C)C)C(=O)N(C)C1
Show InChI InChI=1S/C33H60N2O8/c1-7-24(4)16-14-12-10-8-9-11-13-15-17-28(37)43-25-19-20-26(33(41)35(5)22-25)34-32(40)31(42-6)30(39)29(38)27(36)21-18-23(2)3/h18,21,23-27,29-31,36,38-39H,7-17,19-20,22H2,1-6H3,(H,34,40)/b21-18+/t24?,25-,26-,27+,29-,30+,31+/m0/s1
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n/an/a 3.00E+3n/an/an/an/an/an/a



University of California Santa Cruz

Curated by ChEMBL


Assay Description
Inhibition of methionine aminopeptidase 1


J Nat Prod 72: 588-603 (2010)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM17850
PNG
(3-(3-phenylpropanamido)-N-(1,3-thiazol-2-yl)pyridi...)
Show SMILES O=C(CCc1ccccc1)Nc1cccnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C18H16N4O2S/c23-15(9-8-13-5-2-1-3-6-13)21-14-7-4-10-19-16(14)17(24)22-18-20-11-12-25-18/h1-7,10-12H,8-9H2,(H,21,23)(H,20,22,24)
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n/an/a 3.50E+3n/an/an/an/a7.522



Johns Hopkins University



Assay Description
The MetAP reaction with Co2+ as a cofactor is coupled to a prolyl aminopeptidase (ProAP) using Met-Pro-p-nitroanilide as substrate. MetAP-catalyzed c...


Proc Natl Acad Sci U S A 103: 18148-53 (2006)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50398199
PNG
(CHEMBL1738934)
Show SMILES CO[C@H]([C@H](O)[C@@H](O)[C@H](O)\C=C\C(C)(C)C)C(=O)NCC(N)=O
Show InChI InChI=1S/C14H26N2O6/c1-14(2,3)6-5-8(17)10(19)11(20)12(22-4)13(21)16-7-9(15)18/h5-6,8,10-12,17,19-20H,7H2,1-4H3,(H2,15,18)(H,16,21)/b6-5+/t8-,10+,11-,12-/m1/s1
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n/an/a 3.59E+3n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of Mn(II) form of human methionine aminopeptidase1 expressed in Escherichia coli at 100 mM


J Med Chem 55: 8021-7 (2012)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50435237
PNG
(CHEMBL2392764)
Show SMILES Cc1nc(nc(NCCc2ccccc2)c1F)-c1ccccn1
Show InChI InChI=1S/C18H17FN4/c1-13-16(19)18(21-12-10-14-7-3-2-4-8-14)23-17(22-13)15-9-5-6-11-20-15/h2-9,11H,10,12H2,1H3,(H,21,22,23)
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n/an/a 4.60E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...


Bioorg Med Chem 21: 2600-17 (2013)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50141708
PNG
((R)-3-Amino-2-hydroxy-5-isopropylsulfanyl-pentanoi...)
Show SMILES CC(C)SCC[C@@H](N)[C@H](O)C(=O)NOc1ccccc1
Show InChI InChI=1S/C14H22N2O3S/c1-10(2)20-9-8-12(15)13(17)14(18)16-19-11-6-4-3-5-7-11/h3-7,10,12-13,17H,8-9,15H2,1-2H3,(H,16,18)/t12-,13+/m1/s1
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n/an/a 4.70E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against human methionine aminopeptidase-1


Bioorg Med Chem Lett 14: 865-8 (2004)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50141697
PNG
(3-Amino-2-(S)-hydroxy-4-propylsulfanyl-butyric aci...)
Show SMILES CCCSC[C@@H](N)[C@H](O)C(=O)NNc1ccc(C)cc1
Show InChI InChI=1S/C14H23N3O2S/c1-3-8-20-9-12(15)13(18)14(19)17-16-11-6-4-10(2)5-7-11/h4-7,12-13,16,18H,3,8-9,15H2,1-2H3,(H,17,19)/t12-,13+/m1/s1
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n/an/a 5.00E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against human methionine aminopeptidase-1


Bioorg Med Chem Lett 14: 865-8 (2004)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50398196
PNG
(CHEMBL2181034)
Show SMILES CO[C@H]([C@H](O)[C@@H](O)[C@H](O)\C=C\C(C)(C)C)C(=O)NCCC(c1ccco1)c1ccccc1
Show InChI InChI=1S/C25H35NO6/c1-25(2,3)14-12-19(27)21(28)22(29)23(31-4)24(30)26-15-13-18(20-11-8-16-32-20)17-9-6-5-7-10-17/h5-12,14,16,18-19,21-23,27-29H,13,15H2,1-4H3,(H,26,30)/b14-12+/t18?,19-,21+,22-,23-/m1/s1
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n/an/a 5.14E+3n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of Mn(II) form of human methionine aminopeptidase1 expressed in Escherichia coli at 100 mM


J Med Chem 55: 8021-7 (2012)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50141699
PNG
((2S,3R)-3-Amino-4-cyclohexyl-2-hydroxy-N-(1-naphth...)
Show SMILES CC(NC(=O)[C@@H](O)[C@H](N)CC1CCCCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C22H30N2O2/c1-15(18-12-11-17-9-5-6-10-19(17)14-18)24-22(26)21(25)20(23)13-16-7-3-2-4-8-16/h5-6,9-12,14-16,20-21,25H,2-4,7-8,13,23H2,1H3,(H,24,26)/t15?,20-,21+/m1/s1
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n/an/a 5.30E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against human methionine aminopeptidase-1


Bioorg Med Chem Lett 14: 865-8 (2004)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM68285
PNG
(Bengamide M)
Show SMILES CO[C@H]([C@H](O)[C@@H](O)[C@H](O)\C=C\C(C)C)C(=O)NC1CCC(CN(C)C1=O)C(=O)OCCCCCCCCCCCC(C)C
Show InChI InChI=1S/C33H60N2O8/c1-23(2)16-14-12-10-8-7-9-11-13-15-21-43-33(41)25-18-19-26(32(40)35(5)22-25)34-31(39)30(42-6)29(38)28(37)27(36)20-17-24(3)4/h17,20,23-30,36-38H,7-16,18-19,21-22H2,1-6H3,(H,34,39)/b20-17+/t25?,26?,27-,28+,29-,30-/m1/s1
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n/an/a 5.40E+3n/an/an/an/an/an/a



The Johns Hopkins University



Assay Description
The determined effects of seven bengamide analogs on the enzymatic activity of both recombinated human MetAP1 and MetAP2 in vitro.


Chem Biol 14: 764-74 (2007)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50398197
PNG
(CHEMBL1738933)
Show SMILES CO[C@H]([C@H](O)[C@@H](O)[C@H](O)\C=C\C(C)(C)C)C(=O)NC1Cc2ccccc2C1
Show InChI InChI=1S/C21H31NO5/c1-21(2,3)10-9-16(23)17(24)18(25)19(27-4)20(26)22-15-11-13-7-5-6-8-14(13)12-15/h5-10,15-19,23-25H,11-12H2,1-4H3,(H,22,26)/b10-9+/t16-,17+,18-,19-/m1/s1
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n/an/a 5.58E+3n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of Mn(II) form of human methionine aminopeptidase1 expressed in Escherichia coli at 100 mM


J Med Chem 55: 8021-7 (2012)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM17851
PNG
(3-[(E)-(2-methylpropylidene)amino]-N-(1,3-thiazol-...)
Show SMILES CC(C)C=Nc1cccnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C13H14N4OS/c1-9(2)8-16-10-4-3-5-14-11(10)12(18)17-13-15-6-7-19-13/h3-9H,1-2H3,(H,15,17,18)
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n/an/a 6.40E+3n/an/an/an/a7.522



Johns Hopkins University



Assay Description
The MetAP reaction with Co2+ as a cofactor is coupled to a prolyl aminopeptidase (ProAP) using Met-Pro-p-nitroanilide as substrate. MetAP-catalyzed c...


Proc Natl Acad Sci U S A 103: 18148-53 (2006)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50141711
PNG
(3-Amino-2-(S)-hydroxy-4-isobutylsulfanyl-butyric a...)
Show SMILES CC(C)CSC[C@@H](N)[C@H](O)C(=O)NNc1ccc(C)cc1
Show InChI InChI=1S/C15H25N3O2S/c1-10(2)8-21-9-13(16)14(19)15(20)18-17-12-6-4-11(3)5-7-12/h4-7,10,13-14,17,19H,8-9,16H2,1-3H3,(H,18,20)/t13-,14+/m1/s1
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n/an/a 6.80E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against human methionine aminopeptidase-1


Bioorg Med Chem Lett 14: 865-8 (2004)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50398198
PNG
(CHEMBL2181035)
Show SMILES CO[C@H]([C@H](O)[C@@H](O)[C@H](O)\C=C\C(C)(C)C)C(=O)NCC1CCCN(C1)C(=O)C1CC1
Show InChI InChI=1S/C22H38N2O6/c1-22(2,3)10-9-16(25)17(26)18(27)19(30-4)20(28)23-12-14-6-5-11-24(13-14)21(29)15-7-8-15/h9-10,14-19,25-27H,5-8,11-13H2,1-4H3,(H,23,28)/b10-9+/t14?,16-,17+,18-,19-/m1/s1
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n/an/a 7.45E+3n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of Mn(II) form of human methionine aminopeptidase1 expressed in Escherichia coli at 100 mM


J Med Chem 55: 8021-7 (2012)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM17593
PNG
(CHEMBL170733 | N'-[(2S,3S)-3-amino-2-hydroxy-4-[(2...)
Show SMILES CC(C)CSC[C@@H](N)[C@H](O)C(=O)NNC(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C15H22ClN3O3S/c1-9(2)7-23-8-12(17)13(20)15(22)19-18-14(21)10-4-3-5-11(16)6-10/h3-6,9,12-13,20H,7-8,17H2,1-2H3,(H,18,21)(H,19,22)/t12-,13+/m1/s1
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n/an/a 8.10E+3n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase activity by monitoring the production of free methionine with L...


Cancer Res 63: 7861-9 (2003)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM17593
PNG
(CHEMBL170733 | N'-[(2S,3S)-3-amino-2-hydroxy-4-[(2...)
Show SMILES CC(C)CSC[C@@H](N)[C@H](O)C(=O)NNC(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C15H22ClN3O3S/c1-9(2)7-23-8-12(17)13(20)15(22)19-18-14(21)10-4-3-5-11(16)6-10/h3-6,9,12-13,20H,7-8,17H2,1-2H3,(H,18,21)(H,19,22)/t12-,13+/m1/s1
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n/an/a 8.10E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against human methionine aminopeptidase-1


Bioorg Med Chem Lett 14: 865-8 (2004)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50129661
PNG
(CHEMBL89671 | N-(thiazol-2-yl)picolinamide | Pyrid...)
Show SMILES O=C(Nc1nccs1)c1ccccn1
Show InChI InChI=1S/C9H7N3OS/c13-8(7-3-1-2-4-10-7)12-9-11-5-6-14-9/h1-6H,(H,11,12,13)
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n/an/a 8.10E+3n/an/an/an/an/an/a



Universit£t Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human MetAP1


Bioorg Med Chem Lett 20: 4038-44 (2010)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM17592
PNG
(CHEMBL169958 | N'-[(2S,3R)-3-amino-5-(ethylsulfany...)
Show SMILES CCSCC[C@@H](N)[C@H](O)C(=O)NNC(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C14H20ClN3O3S/c1-2-22-7-6-11(16)12(19)14(21)18-17-13(20)9-4-3-5-10(15)8-9/h3-5,8,11-12,19H,2,6-7,16H2,1H3,(H,17,20)(H,18,21)/t11-,12+/m1/s1
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n/an/a 8.70E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against human methionine aminopeptidase-1


Bioorg Med Chem Lett 14: 865-8 (2004)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50141735
PNG
(3-Amino-5-ethylsulfanyl-2-(S)-hydroxy-pentanoic ac...)
Show SMILES CCSCC[C@@H](N)[C@H](O)C(=O)NNc1cccc2ccccc12
Show InChI InChI=1S/C17H23N3O2S/c1-2-23-11-10-14(18)16(21)17(22)20-19-15-9-5-7-12-6-3-4-8-13(12)15/h3-9,14,16,19,21H,2,10-11,18H2,1H3,(H,20,22)/t14-,16+/m1/s1
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n/an/a 8.90E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against human methionine aminopeptidase-1


Bioorg Med Chem Lett 14: 865-8 (2004)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50435230
PNG
(CHEMBL2392770)
Show SMILES CNc1nc(nc(C)c1Cl)-c1ccccn1
Show InChI InChI=1S/C11H11ClN4/c1-7-9(12)11(13-2)16-10(15-7)8-5-3-4-6-14-8/h3-6H,1-2H3,(H,13,15,16)
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n/an/a 8.90E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...


Bioorg Med Chem 21: 2600-17 (2013)

More data for this
Ligand-Target Pair
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