BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 6 hits Enz. Inhib. hit(s) with Target = 'Methionine aminopeptidase (MetAP2)'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Methionine aminopeptidase (MetAP2)


(Plasmodium falciparum)
BDBM17446
PNG
((3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-m...)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)NC(=O)CCl
Show InChI InChI=1S/C19H28ClNO6/c1-11(2)5-6-13-18(3,27-13)16-15(24-4)12(7-8-19(16)10-25-19)26-17(23)21-14(22)9-20/h5,12-13,15-16H,6-10H2,1-4H3,(H,21,22,23)/t12-,13-,15-,16-,18+,19+/m1/s1
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 2.00E+3n/an/an/an/an/an/a



Johns Hopkins School of Medicine



Assay Description
Enzyme affinity assay using Fumarranol analogs with plasmodium falciparum methionine aminopeptidases (PfMetAPs).


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase (MetAP2)


(Plasmodium falciparum)
BDBM81355
PNG
(Fumarranol Analog, 10)
Show SMILES CO[C@@]12C([C@@]3(C)O[C@@H]3CC=C(C)C)[C@]1(CO)CC[C@H]2O
Show InChI InChI=1S/C16H26O4/c1-10(2)5-6-12-14(3,20-12)13-15(9-17)8-7-11(18)16(13,15)19-4/h5,11-13,17-18H,6-9H2,1-4H3/t11-,12-,13?,14+,15-,16+/m1/s1
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>5.00E+5n/an/an/an/an/an/a



Johns Hopkins School of Medicine



Assay Description
Enzyme affinity assay using Fumarranol analogs with plasmodium falciparum methionine aminopeptidases (PfMetAPs).


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase (MetAP2)


(Plasmodium falciparum)
BDBM50194623
PNG
((1S,5S,6R,E)-5-(hydroxymethyl)-1-methoxy-6-(6-meth...)
Show SMILES CO[C@@]12C(\C(C)=C\CC=C(C)C)[C@]1(CO)CCC2=O
Show InChI InChI=1S/C16H24O3/c1-11(2)6-5-7-12(3)14-15(10-17)9-8-13(18)16(14,15)19-4/h6-7,14,17H,5,8-10H2,1-4H3/b12-7+/t14?,15-,16+/m1/s1
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a>5.00E+5n/an/an/an/an/an/a



Johns Hopkins School of Medicine



Assay Description
Enzyme affinity assay using Fumarranol analogs with plasmodium falciparum methionine aminopeptidases (PfMetAPs).


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase (MetAP2)


(Plasmodium falciparum)
BDBM81354
PNG
(Fumarranol Analog, 9)
Show SMILES CO[C@@]12C([C@@]3(C)O[C@@H]3CC=C(C)C)[C@]1(CO)C\C(=C/c1ccco1)C2=O
Show InChI InChI=1S/C21H26O5/c1-13(2)7-8-16-19(3,26-16)18-20(12-22)11-14(10-15-6-5-9-25-15)17(23)21(18,20)24-4/h5-7,9-10,16,18,22H,8,11-12H2,1-4H3/b14-10+/t16-,18?,19+,20-,21+/m1/s1
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a>5.00E+5n/an/an/an/an/an/a



Johns Hopkins School of Medicine



Assay Description
Enzyme affinity assay using Fumarranol analogs with plasmodium falciparum methionine aminopeptidases (PfMetAPs).


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase (MetAP2)


(Plasmodium falciparum)
BDBM81353
PNG
(Fumarranol Analog, 6)
Show SMILES CO[C@@]12C([C@@]3(C)O[C@@H]3CC=C(C)C)[C@]1(CBr)CCC2=O
Show InChI InChI=1S/C16H23BrO3/c1-10(2)5-6-12-14(3,20-12)13-15(9-17)8-7-11(18)16(13,15)19-4/h5,12-13H,6-9H2,1-4H3/t12-,13?,14+,15-,16+/m1/s1
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a>5.00E+5n/an/an/an/an/an/a



Johns Hopkins School of Medicine



Assay Description
Enzyme affinity assay using Fumarranol analogs with plasmodium falciparum methionine aminopeptidases (PfMetAPs).


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase (MetAP2)


(Plasmodium falciparum)
BDBM50194621
PNG
(6S-(1'R,2'R-1',5'-dimethyl-1',2'-oxiranyl-4'-hexen...)
Show SMILES CO[C@@]12C([C@@]3(C)O[C@@H]3CC=C(C)C)[C@@]1(CCC2=O)C=O
Show InChI InChI=1S/C16H22O4/c1-10(2)5-6-12-14(3,20-12)13-15(9-17)8-7-11(18)16(13,15)19-4/h5,9,12-13H,6-8H2,1-4H3/t12-,13?,14+,15-,16+/m1/s1
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>5.00E+5n/an/an/an/an/an/a



Johns Hopkins School of Medicine



Assay Description
Enzyme affinity assay using Fumarranol analogs with plasmodium falciparum methionine aminopeptidases (PfMetAPs).


Citation and Details
More data for this
Ligand-Target Pair