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Compile Data Set for Download or QSAR

Found 135 hits Enz. Inhib. hit(s) with Target = 'Methionine aminopeptidase 1'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50170371
PNG
(5-Piperidin-1-ylmethyl-thiazole-4-carboxylic acid ...)
Show SMILES O=C(Nc1nccs1)c1ncsc1CN1CCCCC1
Show InChI InChI=1S/C13H16N4OS2/c18-12(16-13-14-4-7-19-13)11-10(20-9-15-11)8-17-5-2-1-3-6-17/h4,7,9H,1-3,5-6,8H2,(H,14,16,18)
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n/an/a 75n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against ScMetAP1 enzyme activity


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50169672
PNG
(5-(Cyclopentanecarbonyl-amino)-thiazole-4-carboxyl...)
Show SMILES O=C(Nc1scnc1C(=O)Nc1nccs1)C1CCCC1
Show InChI InChI=1S/C13H14N4O2S2/c18-10(8-3-1-2-4-8)16-12-9(15-7-21-12)11(19)17-13-14-5-6-20-13/h5-8H,1-4H2,(H,16,18)(H,14,17,19)
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n/an/a 130n/an/an/an/an/an/a



Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Saccharomyces cerevisiae MetAP1 (330 nM)


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50129648
PNG
(3-(4-Methyl-pent-3-enoylamino)-pyridine-2-carboxyl...)
Show SMILES CC(C)=CCC(=O)Nc1cccnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C15H16N4O2S/c1-10(2)5-6-12(20)18-11-4-3-7-16-13(11)14(21)19-15-17-8-9-22-15/h3-5,7-9H,6H2,1-2H3,(H,18,20)(H,17,19,21)
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n/an/a 140n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory activity against type I methionine aminopeptidase from Saccharomyces cerevisiae


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50170369
PNG
(5-(2-Ethoxy-3-methyl-butyl)-thiazole-4-carboxylic ...)
Show SMILES CCOC(Cc1scnc1C(=O)Nc1nccs1)C(C)C
Show InChI InChI=1S/C14H19N3O2S2/c1-4-19-10(9(2)3)7-11-12(16-8-21-11)13(18)17-14-15-5-6-20-14/h5-6,8-10H,4,7H2,1-3H3,(H,15,17,18)
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n/an/a 150n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against ScMetAP1 enzyme activity


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50129642
PNG
(CHEMBL86427 | Phenyl-acetic acid 2-(thiazol-2-ylca...)
Show SMILES O=C(Cc1ccccc1)Oc1cccnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C17H13N3O3S/c21-14(11-12-5-2-1-3-6-12)23-13-7-4-8-18-15(13)16(22)20-17-19-9-10-24-17/h1-10H,11H2,(H,19,20,22)
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n/an/a 200n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory activity against type I methionine aminopeptidase from Saccharomyces cerevisiae


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50169671
PNG
(5-Propionylamino-thiazole-4-carboxylic acid thiazo...)
Show SMILES CCC(=O)Nc1scnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C10H10N4O2S2/c1-2-6(15)13-9-7(12-5-18-9)8(16)14-10-11-3-4-17-10/h3-5H,2H2,1H3,(H,13,15)(H,11,14,16)
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n/an/a 220n/an/an/an/an/an/a



Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Saccharomyces cerevisiae MetAP1 (330 nM)


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50170363
PNG
(5-[2-(2-Chloro-phenyl)-2-methoxy-ethyl]-thiazole-4...)
Show SMILES COC(Cc1scnc1C(=O)Nc1nccs1)c1ccccc1Cl
Show InChI InChI=1S/C16H14ClN3O2S2/c1-22-12(10-4-2-3-5-11(10)17)8-13-14(19-9-24-13)15(21)20-16-18-6-7-23-16/h2-7,9,12H,8H2,1H3,(H,18,20,21)
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n/an/a 230n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against ScMetAP1 enzyme activity


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50169669
PNG
(5-(Cyclobutanecarbonyl-amino)-thiazole-4-carboxyli...)
Show SMILES O=C(Nc1scnc1C(=O)Nc1nccs1)C1CCC1
Show InChI InChI=1S/C12H12N4O2S2/c17-9(7-2-1-3-7)15-11-8(14-6-20-11)10(18)16-12-13-4-5-19-12/h4-7H,1-3H2,(H,15,17)(H,13,16,18)
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n/an/a 250n/an/an/an/an/an/a



Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Saccharomyces cerevisiae MetAP1 (330 nM)


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50170383
PNG
(5-[2-(2-Fluoro-phenyl)-2-methoxy-ethyl]-thiazole-4...)
Show SMILES COC(Cc1scnc1C(=O)Nc1nccs1)c1ccccc1F
Show InChI InChI=1S/C16H14FN3O2S2/c1-22-12(10-4-2-3-5-11(10)17)8-13-14(19-9-24-13)15(21)20-16-18-6-7-23-16/h2-7,9,12H,8H2,1H3,(H,18,20,21)
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n/an/a 270n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against ScMetAP1 enzyme activity


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50170370
PNG
(5-[2-Methoxy-2-(4-methoxy-phenyl)-ethyl]-thiazole-...)
Show SMILES COC(Cc1scnc1C(=O)Nc1nccs1)c1ccc(OC)cc1
Show InChI InChI=1S/C17H17N3O3S2/c1-22-12-5-3-11(4-6-12)13(23-2)9-14-15(19-10-25-14)16(21)20-17-18-7-8-24-17/h3-8,10,13H,9H2,1-2H3,(H,18,20,21)
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n/an/a 310n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against ScMetAP1 enzyme activity


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50129669
PNG
(3-(5-Methyl-hex-4-enoylamino)-pyridine-2-carboxyli...)
Show SMILES CC(C)=CCCC(=O)Nc1cccnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C16H18N4O2S/c1-11(2)5-3-7-13(21)19-12-6-4-8-17-14(12)15(22)20-16-18-9-10-23-16/h4-6,8-10H,3,7H2,1-2H3,(H,19,21)(H,18,20,22)
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n/an/a 310n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory activity against type I methionine aminopeptidase from Saccharomyces cerevisiae


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50129649
PNG
(CHEMBL315098 | Cyclohexanecarboxylic acid 2-(thiaz...)
Show SMILES O=C(Oc1cccnc1C(=O)Nc1nccs1)C1CCCCC1
Show InChI InChI=1S/C16H17N3O3S/c20-14(19-16-18-9-10-23-16)13-12(7-4-8-17-13)22-15(21)11-5-2-1-3-6-11/h4,7-11H,1-3,5-6H2,(H,18,19,20)
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n/an/a 320n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory activity against type I methionine aminopeptidase from Saccharomyces cerevisiae


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50129635
PNG
(3-Formylamino-pyridine-2-carboxylic acid thiazol-2...)
Show SMILES O=CNc1cccnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C10H8N4O2S/c15-6-13-7-2-1-3-11-8(7)9(16)14-10-12-4-5-17-10/h1-6H,(H,13,15)(H,12,14,16)
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n/an/a 320n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory activity against type I methionine aminopeptidase from Saccharomyces cerevisiae


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50170358
PNG
(5-[2-(3-Fluoro-phenyl)-2-methoxy-ethyl]-thiazole-4...)
Show SMILES COC(Cc1scnc1C(=O)Nc1nccs1)c1cccc(F)c1
Show InChI InChI=1S/C16H14FN3O2S2/c1-22-12(10-3-2-4-11(17)7-10)8-13-14(19-9-24-13)15(21)20-16-18-5-6-23-16/h2-7,9,12H,8H2,1H3,(H,18,20,21)
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n/an/a 340n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against ScMetAP1 enzyme activity


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM17849
PNG
(3-(2,2-dimethylpropanamido)-N-(1,3-thiazol-2-yl)py...)
Show SMILES CC(C)(C)C(=O)Nc1cccnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C14H16N4O2S/c1-14(2,3)12(20)17-9-5-4-6-15-10(9)11(19)18-13-16-7-8-21-13/h4-8H,1-3H3,(H,17,20)(H,16,18,19)
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n/an/a 340n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory activity against type I methionine aminopeptidase from Saccharomyces cerevisiae


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50129672
PNG
(3-Propionylamino-pyridine-2-carboxylic acid thiazo...)
Show SMILES CCC(=O)Nc1cccnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C12H12N4O2S/c1-2-9(17)15-8-4-3-5-13-10(8)11(18)16-12-14-6-7-19-12/h3-7H,2H2,1H3,(H,15,17)(H,14,16,18)
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n/an/a 350n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory activity against type I methionine aminopeptidase from Saccharomyces cerevisiae


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50170365
PNG
(5-Pyrrolidin-1-ylmethyl-thiazole-4-carboxylic acid...)
Show SMILES O=C(Nc1nccs1)c1ncsc1CN1CCCC1
Show InChI InChI=1S/C12H14N4OS2/c17-11(15-12-13-3-6-18-12)10-9(19-8-14-10)7-16-4-1-2-5-16/h3,6,8H,1-2,4-5,7H2,(H,13,15,17)
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n/an/a 350n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against ScMetAP1 enzyme activity


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50129672
PNG
(3-Propionylamino-pyridine-2-carboxylic acid thiazo...)
Show SMILES CCC(=O)Nc1cccnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C12H12N4O2S/c1-2-9(17)15-8-4-3-5-13-10(8)11(18)16-12-14-6-7-19-12/h3-7H,2H2,1H3,(H,15,17)(H,14,16,18)
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n/an/a 350n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against Saccharomyces cerevisiae methionine aminopeptidase 1


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50169656
PNG
(5-(2-Methyl-but-3-enoylamino)-thiazole-4-carboxyli...)
Show SMILES CC(C=C)C(=O)Nc1scnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C12H12N4O2S2/c1-3-7(2)9(17)15-11-8(14-6-20-11)10(18)16-12-13-4-5-19-12/h3-7H,1H2,2H3,(H,15,17)(H,13,16,18)
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n/an/a 370n/an/an/an/an/an/a



Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Saccharomyces cerevisiae MetAP1 (330 nM)


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50129663
PNG
(3-But-3-enoylamino-pyridine-2-carboxylic acid thia...)
Show SMILES C=CCC(=O)Nc1cccnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C13H12N4O2S/c1-2-4-10(18)16-9-5-3-6-14-11(9)12(19)17-13-15-7-8-20-13/h2-3,5-8H,1,4H2,(H,16,18)(H,15,17,19)
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n/an/a 380n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory activity against type I methionine aminopeptidase from Saccharomyces cerevisiae


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50129650
PNG
(CHEMBL314448 | Propionic acid 2-(thiazol-2-ylcarba...)
Show SMILES CCC(=O)Oc1cccnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C12H11N3O3S/c1-2-9(16)18-8-4-3-5-13-10(8)11(17)15-12-14-6-7-19-12/h3-7H,2H2,1H3,(H,14,15,17)
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n/an/a 380n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory activity against type I methionine aminopeptidase from Saccharomyces cerevisiae


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50170366
PNG
(5-[2-(4-Fluoro-phenyl)-2-methoxy-ethyl]-thiazole-4...)
Show SMILES COC(Cc1scnc1C(=O)Nc1nccs1)c1ccc(F)cc1
Show InChI InChI=1S/C16H14FN3O2S2/c1-22-12(10-2-4-11(17)5-3-10)8-13-14(19-9-24-13)15(21)20-16-18-6-7-23-16/h2-7,9,12H,8H2,1H3,(H,18,20,21)
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n/an/a 390n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against ScMetAP1 enzyme activity


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50129641
PNG
(2-Methyl-but-2-enoic acid 2-(thiazol-2-ylcarbamoyl...)
Show SMILES C\C=C(/C)C(=O)Oc1cccnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C14H13N3O3S/c1-3-9(2)13(19)20-10-5-4-6-15-11(10)12(18)17-14-16-7-8-21-14/h3-8H,1-2H3,(H,16,17,18)/b9-3+
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n/an/a 390n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory activity against type I methionine aminopeptidase from Saccharomyces cerevisiae


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50170389
PNG
(5-(2-Cyclohexyl-2-methoxy-ethyl)-thiazole-4-carbox...)
Show SMILES COC(Cc1scnc1C(=O)Nc1nccs1)C1CCCCC1
Show InChI InChI=1S/C16H21N3O2S2/c1-21-12(11-5-3-2-4-6-11)9-13-14(18-10-23-13)15(20)19-16-17-7-8-22-16/h7-8,10-12H,2-6,9H2,1H3,(H,17,19,20)
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n/an/a 400n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against ScMetAP1 enzyme activity


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50170361
PNG
(5-(2-Piperidin-1-yl-ethyl)-thiazole-4-carboxylic a...)
Show SMILES O=C(Nc1nccs1)c1ncsc1CCN1CCCCC1
Show InChI InChI=1S/C14H18N4OS2/c19-13(17-14-15-5-9-20-14)12-11(21-10-16-12)4-8-18-6-2-1-3-7-18/h5,9-10H,1-4,6-8H2,(H,15,17,19)
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n/an/a 410n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against ScMetAP1 enzyme activity


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50170382
PNG
(5-(2-Methoxy-2-phenyl-ethyl)-thiazole-4-carboxylic...)
Show SMILES COC(Cc1scnc1C(=O)Nc1nccs1)c1ccccc1
Show InChI InChI=1S/C16H15N3O2S2/c1-21-12(11-5-3-2-4-6-11)9-13-14(18-10-23-13)15(20)19-16-17-7-8-22-16/h2-8,10,12H,9H2,1H3,(H,17,19,20)
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n/an/a 440n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against ScMetAP1 enzyme activity


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50170384
PNG
(5-((S)-2-Methoxy-2-phenyl-ethyl)-thiazole-4-carbox...)
Show SMILES CO[C@@H](Cc1scnc1C(=O)Nc1nccs1)c1ccccc1
Show InChI InChI=1S/C16H15N3O2S2/c1-21-12(11-5-3-2-4-6-11)9-13-14(18-10-23-13)15(20)19-16-17-7-8-22-16/h2-8,10,12H,9H2,1H3,(H,17,19,20)/t12-/m0/s1
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n/an/a 450n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against ScMetAP1 enzyme activity


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50170388
PNG
(5-((R)-2-Methoxy-2-phenyl-ethyl)-thiazole-4-carbox...)
Show SMILES CO[C@H](Cc1scnc1C(=O)Nc1nccs1)c1ccccc1
Show InChI InChI=1S/C16H15N3O2S2/c1-21-12(11-5-3-2-4-6-11)9-13-14(18-10-23-13)15(20)19-16-17-7-8-22-16/h2-8,10,12H,9H2,1H3,(H,17,19,20)/t12-/m1/s1
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n/an/a 450n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against ScMetAP1 enzyme activity


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50170381
PNG
(5-(2-Methoxy-hexyl)-thiazole-4-carboxylic acid thi...)
Show SMILES CCCCC(Cc1scnc1C(=O)Nc1nccs1)OC
Show InChI InChI=1S/C14H19N3O2S2/c1-3-4-5-10(19-2)8-11-12(16-9-21-11)13(18)17-14-15-6-7-20-14/h6-7,9-10H,3-5,8H2,1-2H3,(H,15,17,18)
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n/an/a 450n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against ScMetAP1 enzyme activity


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50169686
PNG
(5-(4-Fluoro-benzoylamino)-thiazole-4-carboxylic ac...)
Show SMILES Fc1ccc(cc1)C(=O)Nc1scnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C14H9FN4O2S2/c15-9-3-1-8(2-4-9)11(20)18-13-10(17-7-23-13)12(21)19-14-16-5-6-22-14/h1-7H,(H,18,20)(H,16,19,21)
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n/an/a 480n/an/an/an/an/an/a



Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Saccharomyces cerevisiae MetAP1 (330 nM)


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50129646
PNG
(3-Methyl-but-2-enoic acid 2-(thiazol-2-ylcarbamoyl...)
Show SMILES CC(C)=CC(=O)Oc1cccnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C14H13N3O3S/c1-9(2)8-11(18)20-10-4-3-5-15-12(10)13(19)17-14-16-6-7-21-14/h3-8H,1-2H3,(H,16,17,19)
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n/an/a 490n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory activity against type I methionine aminopeptidase from Saccharomyces cerevisiae


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50169679
PNG
(5-(2-Methoxy-3-methyl-butyl)-thiazole-4-carboxylic...)
Show SMILES COC(Cc1scnc1C(=O)Nc1nccs1)C(C)C
Show InChI InChI=1S/C13H17N3O2S2/c1-8(2)9(18-3)6-10-11(15-7-20-10)12(17)16-13-14-4-5-19-13/h4-5,7-9H,6H2,1-3H3,(H,14,16,17)
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n/an/a 500n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against ScMetAP1 enzyme activity


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50170360
PNG
(5-(2-Methoxy-4-methyl-pentyl)-thiazole-4-carboxyli...)
Show SMILES COC(CC(C)C)Cc1scnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C14H19N3O2S2/c1-9(2)6-10(19-3)7-11-12(16-8-21-11)13(18)17-14-15-4-5-20-14/h4-5,8-10H,6-7H2,1-3H3,(H,15,17,18)
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n/an/a 500n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against ScMetAP1 enzyme activity


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50169679
PNG
(5-(2-Methoxy-3-methyl-butyl)-thiazole-4-carboxylic...)
Show SMILES COC(Cc1scnc1C(=O)Nc1nccs1)C(C)C
Show InChI InChI=1S/C13H17N3O2S2/c1-8(2)9(18-3)6-10-11(15-7-20-10)12(17)16-13-14-4-5-19-13/h4-5,7-9H,6H2,1-3H3,(H,14,16,17)
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n/an/a 500n/an/an/an/an/an/a



Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Saccharomyces cerevisiae MetAP1 (330 nM)


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50170374
PNG
(5-[2-(3-Chloro-phenyl)-2-methoxy-ethyl]-thiazole-4...)
Show SMILES COC(Cc1scnc1C(=O)Nc1nccs1)c1cccc(Cl)c1
Show InChI InChI=1S/C16H14ClN3O2S2/c1-22-12(10-3-2-4-11(17)7-10)8-13-14(19-9-24-13)15(21)20-16-18-5-6-23-16/h2-7,9,12H,8H2,1H3,(H,18,20,21)
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n/an/a 520n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against ScMetAP1 enzyme activity


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50129675
PNG
(2-Methoxy-benzoic acid 2-(thiazol-2-ylcarbamoyl)-p...)
Show SMILES COc1ccccc1C(=O)Oc1cccnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C17H13N3O4S/c1-23-12-6-3-2-5-11(12)16(22)24-13-7-4-8-18-14(13)15(21)20-17-19-9-10-25-17/h2-10H,1H3,(H,19,20,21)
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n/an/a 550n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory activity against type I methionine aminopeptidase from Saccharomyces cerevisiae


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50170380
PNG
(Benzyloxy-acetic acid 2-[4-(thiazol-2-ylcarbamoyl)...)
Show SMILES O=C(COCc1ccccc1)OCCc1scnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C18H17N3O4S2/c22-15(11-24-10-13-4-2-1-3-5-13)25-8-6-14-16(20-12-27-14)17(23)21-18-19-7-9-26-18/h1-5,7,9,12H,6,8,10-11H2,(H,19,21,23)
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n/an/a 550n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against ScMetAP1 enzyme activity


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50170378
PNG
(5-[2-(4-Chloro-phenyl)-2-methoxy-ethyl]-thiazole-4...)
Show SMILES COC(Cc1scnc1C(=O)Nc1nccs1)c1ccc(Cl)cc1
Show InChI InChI=1S/C16H14ClN3O2S2/c1-22-12(10-2-4-11(17)5-3-10)8-13-14(19-9-24-13)15(21)20-16-18-6-7-23-16/h2-7,9,12H,8H2,1H3,(H,18,20,21)
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n/an/a 570n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against ScMetAP1 enzyme activity


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50170367
PNG
(5-[2-Methoxy-2-(2-methoxy-phenyl)-ethyl]-thiazole-...)
Show SMILES COC(Cc1scnc1C(=O)Nc1nccs1)c1ccccc1OC
Show InChI InChI=1S/C17H17N3O3S2/c1-22-12-6-4-3-5-11(12)13(23-2)9-14-15(19-10-25-14)16(21)20-17-18-7-8-24-17/h3-8,10,13H,9H2,1-2H3,(H,18,20,21)
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n/an/a 570n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against ScMetAP1 enzyme activity


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50129656
PNG
(3-Hexanoylamino-pyridine-2-carboxylic acid thiazol...)
Show SMILES CCCCCC(=O)Nc1cccnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C15H18N4O2S/c1-2-3-4-7-12(20)18-11-6-5-8-16-13(11)14(21)19-15-17-9-10-22-15/h5-6,8-10H,2-4,7H2,1H3,(H,18,20)(H,17,19,21)
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n/an/a 620n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory activity against type I methionine aminopeptidase from Saccharomyces cerevisiae


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50129656
PNG
(3-Hexanoylamino-pyridine-2-carboxylic acid thiazol...)
Show SMILES CCCCCC(=O)Nc1cccnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C15H18N4O2S/c1-2-3-4-7-12(20)18-11-6-5-8-16-13(11)14(21)19-15-17-9-10-22-15/h5-6,8-10H,2-4,7H2,1H3,(H,18,20)(H,17,19,21)
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n/an/a 620n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against Saccharomyces cerevisiae methionine aminopeptidase 1


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50169670
PNG
(5-Phenethyl-thiazole-4-carboxylic acid thiazol-2-y...)
Show SMILES O=C(Nc1nccs1)c1ncsc1CCc1ccccc1
Show InChI InChI=1S/C15H13N3OS2/c19-14(18-15-16-8-9-20-15)13-12(21-10-17-13)7-6-11-4-2-1-3-5-11/h1-5,8-10H,6-7H2,(H,16,18,19)
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n/an/a 660n/an/an/an/an/an/a



Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Saccharomyces cerevisiae MetAP1 (330 nM)


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50169685
PNG
(CHEMBL360353 | N-[4-(Thiazol-2-ylcarbamoyl)-thiazo...)
Show SMILES CCOC(=O)CC(=O)Nc1scnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C12H12N4O4S2/c1-2-20-8(18)5-7(17)15-11-9(14-6-22-11)10(19)16-12-13-3-4-21-12/h3-4,6H,2,5H2,1H3,(H,15,17)(H,13,16,19)
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n/an/a 670n/an/an/an/an/an/a



Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Saccharomyces cerevisiae MetAP1 (330 nM)


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50170359
PNG
(5-(Methoxy-phenyl-methyl)-thiazole-4-carboxylic ac...)
Show SMILES COC(c1scnc1C(=O)Nc1nccs1)c1ccccc1
Show InChI InChI=1S/C15H13N3O2S2/c1-20-12(10-5-3-2-4-6-10)13-11(17-9-22-13)14(19)18-15-16-7-8-21-15/h2-9,12H,1H3,(H,16,18,19)
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n/an/a 750n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against ScMetAP1 enzyme activity


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50129640
PNG
(3-(3-Methyl-but-2-enoylamino)-pyridine-2-carboxyli...)
Show SMILES CC(C)=CC(=O)Nc1cccnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C14H14N4O2S/c1-9(2)8-11(19)17-10-4-3-5-15-12(10)13(20)18-14-16-6-7-21-14/h3-8H,1-2H3,(H,17,19)(H,16,18,20)
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n/an/a 770n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory activity against type I methionine aminopeptidase from Saccharomyces cerevisiae


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50160043
PNG
(3-Benzyloxy-pyridine-2-carboxylic acid thiazol-2-y...)
Show SMILES O=C(Nc1nccs1)c1ncccc1OCc1ccccc1
Show InChI InChI=1S/C16H13N3O2S/c20-15(19-16-18-9-10-22-16)14-13(7-4-8-17-14)21-11-12-5-2-1-3-6-12/h1-10H,11H2,(H,18,19,20)
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n/an/a 770n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against Saccharomyces cerevisiae methionine aminopeptidase 1


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50129636
PNG
(2,2-Dimethyl-propionic acid 2-(thiazol-2-ylcarbamo...)
Show SMILES CC(C)(C)C(=O)Oc1cccnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C14H15N3O3S/c1-14(2,3)12(19)20-9-5-4-6-15-10(9)11(18)17-13-16-7-8-21-13/h4-8H,1-3H3,(H,16,17,18)
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n/an/a 780n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory activity against type I methionine aminopeptidase from Saccharomyces cerevisiae


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50170368
PNG
(CHEMBL363875 | Cyclopentanecarboxylic acid 2-[4-(t...)
Show SMILES O=C(OCCc1scnc1C(=O)Nc1nccs1)C1CCCC1
Show InChI InChI=1S/C15H17N3O3S2/c19-13(18-15-16-6-8-22-15)12-11(23-9-17-12)5-7-21-14(20)10-3-1-2-4-10/h6,8-10H,1-5,7H2,(H,16,18,19)
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n/an/a 800n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against ScMetAP1 enzyme activity


Citation and Details
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50129666
PNG
(3-Phenylacetylamino-pyridine-2-carboxylic acid thi...)
Show SMILES O=C(Cc1ccccc1)Nc1cccnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C17H14N4O2S/c22-14(11-12-5-2-1-3-6-12)20-13-7-4-8-18-15(13)16(23)21-17-19-9-10-24-17/h1-10H,11H2,(H,20,22)(H,19,21,23)
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n/an/a 820n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory activity against type I methionine aminopeptidase from Saccharomyces cerevisiae


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Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50169675
PNG
(5-(2-Pyrrolidin-1-yl-acetylamino)-thiazole-4-carbo...)
Show SMILES O=C(CN1CCCC1)Nc1scnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C13H15N5O2S2/c19-9(7-18-4-1-2-5-18)16-12-10(15-8-22-12)11(20)17-13-14-3-6-21-13/h3,6,8H,1-2,4-5,7H2,(H,16,19)(H,14,17,20)
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n/an/a 860n/an/an/an/an/an/a



Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Saccharomyces cerevisiae MetAP1 (330 nM)


Citation and Details
More data for this
Ligand-Target Pair
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