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Compile Data Set for Download or QSAR

Found 80 hits Enz. Inhib. hit(s) with Target = 'Microtubule-associated protein 2'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Microtubule-associated protein 2


(Homo sapiens)
BDBM50097408
PNG
(CHEMBL3586452)
Show SMILES Cc1ccccc1-c1cnc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C18H13F3N4O/c1-10-4-2-3-5-12(10)11-6-14-16(22-7-11)15-13(8-23-24-15)17(26)25(14)9-18(19,20)21/h2-8H,9H2,1H3,(H,23,24)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Structure Guided Chemistry, Dart Neuroscience LLC , 12278 Scripps Summit Drive, San Diego, California 92131, United States.

Curated by ChEMBL


Assay Description
Inhibition of human METAP2 using Met-Pro-Arg-pNa substrate by para-nitroanilide chromophore release detection assay


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50097405
PNG
(CHEMBL3586455)
Show SMILES CNS(=O)(=O)c1ccccc1-c1cnc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C18H14F3N5O3S/c1-22-30(28,29)14-5-3-2-4-11(14)10-6-13-16(23-7-10)15-12(8-24-25-15)17(27)26(13)9-18(19,20)21/h2-8,22H,9H2,1H3,(H,24,25)
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n/an/a 4.00E+3n/an/an/an/an/an/a



Structure Guided Chemistry, Dart Neuroscience LLC , 12278 Scripps Summit Drive, San Diego, California 92131, United States.

Curated by ChEMBL


Assay Description
Inhibition of human METAP2 using Met-Pro-Arg-pNa substrate by para-nitroanilide chromophore release detection assay


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50097403
PNG
(CHEMBL3586457)
Show SMILES CN1CCN(CC1)c1ccc(cn1)-c1cnc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C21H20F3N7O/c1-29-4-6-30(7-5-29)17-3-2-13(9-25-17)14-8-16-19(26-10-14)18-15(11-27-28-18)20(32)31(16)12-21(22,23)24/h2-3,8-11H,4-7,12H2,1H3,(H,27,28)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Structure Guided Chemistry, Dart Neuroscience LLC , 12278 Scripps Summit Drive, San Diego, California 92131, United States.

Curated by ChEMBL


Assay Description
Inhibition of human METAP2 using Met-Pro-Arg-pNa substrate by para-nitroanilide chromophore release detection assay


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50097404
PNG
(CHEMBL3586456)
Show SMILES CS(=O)(=O)Nc1ccccc1-c1cnc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C18H14F3N5O3S/c1-30(28,29)25-13-5-3-2-4-11(13)10-6-14-16(22-7-10)15-12(8-23-24-15)17(27)26(14)9-18(19,20)21/h2-8,25H,9H2,1H3,(H,23,24)
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n/an/a 8.00E+3n/an/an/an/an/an/a



Structure Guided Chemistry, Dart Neuroscience LLC , 12278 Scripps Summit Drive, San Diego, California 92131, United States.

Curated by ChEMBL


Assay Description
Inhibition of human METAP2 using Met-Pro-Arg-pNa substrate by para-nitroanilide chromophore release detection assay


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50433375
PNG
(CHEMBL472879 | GNF-Pf-359)
Show SMILES Cc1nc(nc(NCCc2ccccc2)c1Cl)-c1ccccn1
Show InChI InChI=1S/C18H17ClN4/c1-13-16(19)18(21-12-10-14-7-3-2-4-8-14)23-17(22-13)15-9-5-6-11-20-15/h2-9,11H,10,12H2,1H3,(H,21,22,23)
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n/an/a 9.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435218
PNG
(CHEMBL2392899)
Show SMILES Cc1nc(nc(NC[C@H](NS(=O)(=O)CCN2CCNCC2)c2ccccc2)c1Cl)-c1ccccn1
Show InChI InChI=1S/C24H30ClN7O2S/c1-18-22(25)24(30-23(29-18)20-9-5-6-10-27-20)28-17-21(19-7-3-2-4-8-19)31-35(33,34)16-15-32-13-11-26-12-14-32/h2-10,21,26,31H,11-17H2,1H3,(H,28,29,30)/t21-/m0/s1
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n/an/a 9.40E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50097401
PNG
(CHEMBL3586459)
Show SMILES CN1CCN(CC1)c1cc(ccn1)-c1cc2n(CC(F)(F)F)c(=O)c3cn[nH]c3c2cn1
Show InChI InChI=1S/C21H20F3N7O/c1-29-4-6-30(7-5-29)18-8-13(2-3-25-18)16-9-17-14(10-26-16)19-15(11-27-28-19)20(32)31(17)12-21(22,23)24/h2-3,8-11H,4-7,12H2,1H3,(H,27,28)
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n/an/a 1.10E+4n/an/an/an/an/an/a



Structure Guided Chemistry, Dart Neuroscience LLC , 12278 Scripps Summit Drive, San Diego, California 92131, United States.

Curated by ChEMBL


Assay Description
Inhibition of human METAP2 using Met-Pro-Arg-pNa substrate by para-nitroanilide chromophore release detection assay


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50097412
PNG
(CHEMBL3586448)
Show SMILES FC(F)(F)Cn1c2cc(cnc2c2[nH]ncc2c1=O)-c1cccnc1Cl
Show InChI InChI=1S/C16H9ClF3N5O/c17-14-9(2-1-3-21-14)8-4-11-13(22-5-8)12-10(6-23-24-12)15(26)25(11)7-16(18,19)20/h1-6H,7H2,(H,23,24)
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n/an/a 1.10E+4n/an/an/an/an/an/a



Structure Guided Chemistry, Dart Neuroscience LLC , 12278 Scripps Summit Drive, San Diego, California 92131, United States.

Curated by ChEMBL


Assay Description
Inhibition of human METAP2 using Met-Pro-Arg-pNa substrate by para-nitroanilide chromophore release detection assay


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435231
PNG
(CHEMBL2392769)
Show SMILES CN(Cc1ccccc1)c1nc(nc(C)c1Cl)-c1ccccn1
Show InChI InChI=1S/C18H17ClN4/c1-13-16(19)18(23(2)12-14-8-4-3-5-9-14)22-17(21-13)15-10-6-7-11-20-15/h3-11H,12H2,1-2H3
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n/an/a 1.30E+4n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50097399
PNG
(CHEMBL3586461)
Show SMILES FC(F)(F)Cn1c2cc(ncc2c2[nH]ncc2c1=O)-c1ncccc1Cl
Show InChI InChI=1S/C16H9ClF3N5O/c17-10-2-1-3-21-14(10)11-4-12-8(5-22-11)13-9(6-23-24-13)15(26)25(12)7-16(18,19)20/h1-6H,7H2,(H,23,24)
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n/an/a 1.30E+4n/an/an/an/an/an/a



Structure Guided Chemistry, Dart Neuroscience LLC , 12278 Scripps Summit Drive, San Diego, California 92131, United States.

Curated by ChEMBL


Assay Description
Inhibition of human METAP2 using Met-Pro-Arg-pNa substrate by para-nitroanilide chromophore release detection assay


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435230
PNG
(CHEMBL2392770)
Show SMILES CNc1nc(nc(C)c1Cl)-c1ccccn1
Show InChI InChI=1S/C11H11ClN4/c1-7-9(12)11(13-2)16-10(15-7)8-5-3-4-6-14-8/h3-6H,1-2H3,(H,13,15,16)
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n/an/a 1.40E+4n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50097407
PNG
(CHEMBL3586453)
Show SMILES FC(F)(F)Cn1c2cc(cnc2c2[nH]ncc2c1=O)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C18H10F6N4O/c19-17(20,21)8-28-13-5-9(10-3-1-2-4-12(10)18(22,23)24)6-25-15(13)14-11(16(28)29)7-26-27-14/h1-7H,8H2,(H,26,27)
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n/an/a 2.00E+4n/an/an/an/an/an/a



Structure Guided Chemistry, Dart Neuroscience LLC , 12278 Scripps Summit Drive, San Diego, California 92131, United States.

Curated by ChEMBL


Assay Description
Inhibition of human METAP2 using Met-Pro-Arg-pNa substrate by para-nitroanilide chromophore release detection assay


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50097400
PNG
(CHEMBL3586460)
Show SMILES FC(F)(F)Cn1c2cc(ncc2c2[nH]ncc2c1=O)-c1ccccc1CNC1CC1
Show InChI InChI=1S/C21H18F3N5O/c22-21(23,24)11-29-18-7-17(14-4-2-1-3-12(14)8-25-13-5-6-13)26-9-15(18)19-16(20(29)30)10-27-28-19/h1-4,7,9-10,13,25H,5-6,8,11H2,(H,27,28)
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n/an/a 2.10E+4n/an/an/an/an/an/a



Structure Guided Chemistry, Dart Neuroscience LLC , 12278 Scripps Summit Drive, San Diego, California 92131, United States.

Curated by ChEMBL


Assay Description
Inhibition of human METAP2 using Met-Pro-Arg-pNa substrate by para-nitroanilide chromophore release detection assay


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435224
PNG
(CHEMBL2392893)
Show SMILES Cc1nc(nc(NC[C@H](NC(=O)CCN2CCNCC2)c2ccccc2)c1Cl)-c1ccccn1
Show InChI InChI=1S/C25H30ClN7O/c1-18-23(26)25(32-24(30-18)20-9-5-6-11-28-20)29-17-21(19-7-3-2-4-8-19)31-22(34)10-14-33-15-12-27-13-16-33/h2-9,11,21,27H,10,12-17H2,1H3,(H,31,34)(H,29,30,32)/t21-/m0/s1
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n/an/a 2.20E+4n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50097410
PNG
(CHEMBL3586450)
Show SMILES CN1CCN(CC1)c1cncc(c1)-c1cnc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C21H20F3N7O/c1-29-2-4-30(5-3-29)15-6-13(8-25-10-15)14-7-17-19(26-9-14)18-16(11-27-28-18)20(32)31(17)12-21(22,23)24/h6-11H,2-5,12H2,1H3,(H,27,28)
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n/an/a 2.40E+4n/an/an/an/an/an/a



Structure Guided Chemistry, Dart Neuroscience LLC , 12278 Scripps Summit Drive, San Diego, California 92131, United States.

Curated by ChEMBL


Assay Description
Inhibition of human METAP2 using Met-Pro-Arg-pNa substrate by para-nitroanilide chromophore release detection assay


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435237
PNG
(CHEMBL2392764)
Show SMILES Cc1nc(nc(NCCc2ccccc2)c1F)-c1ccccn1
Show InChI InChI=1S/C18H17FN4/c1-13-16(19)18(21-12-10-14-7-3-2-4-8-14)23-17(22-13)15-9-5-6-11-20-15/h2-9,11H,10,12H2,1H3,(H,21,22,23)
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n/an/a 6.20E+4n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50097411
PNG
(CHEMBL3586449)
Show SMILES FC(F)(F)Cn1c2cc(cnc2c2[nH]ncc2c1=O)-c1cccnc1
Show InChI InChI=1S/C16H10F3N5O/c17-16(18,19)8-24-12-4-10(9-2-1-3-20-5-9)6-21-14(12)13-11(15(24)25)7-22-23-13/h1-7H,8H2,(H,22,23)
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n/an/a 6.40E+4n/an/an/an/an/an/a



Structure Guided Chemistry, Dart Neuroscience LLC , 12278 Scripps Summit Drive, San Diego, California 92131, United States.

Curated by ChEMBL


Assay Description
Inhibition of human METAP2 using Met-Pro-Arg-pNa substrate by para-nitroanilide chromophore release detection assay


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435217
PNG
(CHEMBL2392900)
Show SMILES Cc1nc(nc(NC[C@H](NS(=O)(=O)CCN2CCN(CCO)CC2)c2ccccc2)c1Cl)-c1ccccn1
Show InChI InChI=1S/C26H34ClN7O3S/c1-20-24(27)26(31-25(30-20)22-9-5-6-10-28-22)29-19-23(21-7-3-2-4-8-21)32-38(36,37)18-16-34-13-11-33(12-14-34)15-17-35/h2-10,23,32,35H,11-19H2,1H3,(H,29,30,31)/t23-/m0/s1
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n/an/a 9.50E+4n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435234
PNG
(CHEMBL2392766)
Show SMILES Cc1nc(nc(SCCc2ccccc2)c1Cl)-c1ccccn1
Show InChI InChI=1S/C18H16ClN3S/c1-13-16(19)18(23-12-10-14-7-3-2-4-8-14)22-17(21-13)15-9-5-6-11-20-15/h2-9,11H,10,12H2,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435233
PNG
(CHEMBL2392767)
Show SMILES Cc1nc(nc(NCc2ccccc2)c1Cl)-c1cccnc1
Show InChI InChI=1S/C17H15ClN4/c1-12-15(18)17(20-10-13-6-3-2-4-7-13)22-16(21-12)14-8-5-9-19-11-14/h2-9,11H,10H2,1H3,(H,20,21,22)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435232
PNG
(CHEMBL2392768)
Show SMILES Cc1nc(nc(SCc2ccccc2)c1Cl)-c1ccccn1
Show InChI InChI=1S/C17H14ClN3S/c1-12-15(18)17(22-11-13-7-3-2-4-8-13)21-16(20-12)14-9-5-6-10-19-14/h2-10H,11H2,1H3
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Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435236
PNG
(CHEMBL2392765)
Show SMILES Cc1nc(nc(NCCc2ccccc2)c1C)-c1ccccn1
Show InChI InChI=1S/C19H20N4/c1-14-15(2)22-19(17-10-6-7-12-20-17)23-18(14)21-13-11-16-8-4-3-5-9-16/h3-10,12H,11,13H2,1-2H3,(H,21,22,23)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50433377
PNG
(CHEMBL2375628)
Show SMILES Cc1nc(nc(NCCNc2ccc(cn2)C(F)(F)F)c1Cl)-c1ccccn1
Show InChI InChI=1S/C18H16ClF3N6/c1-11-15(19)17(28-16(27-11)13-4-2-3-7-23-13)25-9-8-24-14-6-5-12(10-26-14)18(20,21)22/h2-7,10H,8-9H2,1H3,(H,24,26)(H,25,27,28)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435228
PNG
(CHEMBL460432)
Show SMILES Cc1nc(nc(N2CCN(CCO)CC2)c1Cl)-c1ccccn1
Show InChI InChI=1S/C16H20ClN5O/c1-12-14(17)16(22-8-6-21(7-9-22)10-11-23)20-15(19-12)13-4-2-3-5-18-13/h2-5,23H,6-11H2,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435227
PNG
(CHEMBL2392772)
Show SMILES Cc1nc(nc(NC2CCN(CC2)c2ncc(cc2Cl)C(F)(F)F)c1Cl)-c1ccccn1
Show InChI InChI=1S/C21H19Cl2F3N6/c1-12-17(23)19(31-18(29-12)16-4-2-3-7-27-16)30-14-5-8-32(9-6-14)20-15(22)10-13(11-28-20)21(24,25)26/h2-4,7,10-11,14H,5-6,8-9H2,1H3,(H,29,30,31)
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Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435235
PNG
(CHEMBL454036)
Show SMILES Cc1cc(NCCc2ccccc2)nc(n1)-c1ccccn1
Show InChI InChI=1S/C18H18N4/c1-14-13-17(20-12-10-15-7-3-2-4-8-15)22-18(21-14)16-9-5-6-11-19-16/h2-9,11,13H,10,12H2,1H3,(H,20,21,22)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435229
PNG
(CHEMBL2392771)
Show SMILES Cc1nc(nc(NCCNc2cccc(n2)C(F)(F)F)c1Cl)-c1ccccn1
Show InChI InChI=1S/C18H16ClF3N6/c1-11-15(19)17(28-16(26-11)12-5-2-3-8-23-12)25-10-9-24-14-7-4-6-13(27-14)18(20,21)22/h2-8H,9-10H2,1H3,(H,24,27)(H,25,26,28)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435221
PNG
(CHEMBL2392896)
Show SMILES Cc1nc(nc(NC[C@H](NCCCN2CCN(CCO)CC2)c2ccccc2)c1Cl)-c1ccccn1
Show InChI InChI=1S/C27H36ClN7O/c1-21-25(28)27(33-26(32-21)23-10-5-6-11-29-23)31-20-24(22-8-3-2-4-9-22)30-12-7-13-34-14-16-35(17-15-34)18-19-36/h2-6,8-11,24,30,36H,7,12-20H2,1H3,(H,31,32,33)/t24-/m0/s1
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n/an/a 1.01E+5n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435222
PNG
(CHEMBL2392895)
Show SMILES Cc1nc(nc(NC[C@H](NCCCN2CCNCC2)c2ccccc2)c1Cl)-c1ccccn1
Show InChI InChI=1S/C25H32ClN7/c1-19-23(26)25(32-24(31-19)21-10-5-6-11-28-21)30-18-22(20-8-3-2-4-9-20)29-12-7-15-33-16-13-27-14-17-33/h2-6,8-11,22,27,29H,7,12-18H2,1H3,(H,30,31,32)/t22-/m0/s1
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n/an/a 1.08E+5n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435226
PNG
(CHEMBL2392891)
Show SMILES Cc1nc(nc(NC[C@H](NC(=O)CCN2CCN(CCO)CC2)c2ccccc2)c1Cl)-c1ccccn1
Show InChI InChI=1S/C27H34ClN7O2/c1-20-25(28)27(33-26(31-20)22-9-5-6-11-29-22)30-19-23(21-7-3-2-4-8-21)32-24(37)10-12-34-13-15-35(16-14-34)17-18-36/h2-9,11,23,36H,10,12-19H2,1H3,(H,32,37)(H,30,31,33)/t23-/m0/s1
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n/an/a 1.14E+5n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50097402
PNG
(CHEMBL3586458)
Show SMILES FC(F)(F)Cn1c2cc(cnc2c2[nH]ncc2c1=O)-c1ccccc1N1CCOCC1
Show InChI InChI=1S/C21H18F3N5O2/c22-21(23,24)12-29-17-9-13(10-25-19(17)18-15(20(29)30)11-26-27-18)14-3-1-2-4-16(14)28-5-7-31-8-6-28/h1-4,9-11H,5-8,12H2,(H,26,27)
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n/an/a 1.87E+5n/an/an/an/an/an/a



Structure Guided Chemistry, Dart Neuroscience LLC , 12278 Scripps Summit Drive, San Diego, California 92131, United States.

Curated by ChEMBL


Assay Description
Inhibition of human METAP2 using Met-Pro-Arg-pNa substrate by para-nitroanilide chromophore release detection assay


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435220
PNG
(CHEMBL2392897)
Show SMILES Cc1nc(nc(NC[C@H](NCCCCN2CCNCC2)c2ccccc2)c1Cl)-c1ccccn1
Show InChI InChI=1S/C26H34ClN7/c1-20-24(27)26(33-25(32-20)22-11-5-6-12-29-22)31-19-23(21-9-3-2-4-10-21)30-13-7-8-16-34-17-14-28-15-18-34/h2-6,9-12,23,28,30H,7-8,13-19H2,1H3,(H,31,32,33)/t23-/m0/s1
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n/an/a 1.88E+5n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435219
PNG
(CHEMBL2392898)
Show SMILES Cc1nc(nc(NC[C@H](NCCCCN2CCN(CCO)CC2)c2ccccc2)c1Cl)-c1ccccn1
Show InChI InChI=1S/C28H38ClN7O/c1-22-26(29)28(34-27(33-22)24-11-5-6-12-30-24)32-21-25(23-9-3-2-4-10-23)31-13-7-8-14-35-15-17-36(18-16-35)19-20-37/h2-6,9-12,25,31,37H,7-8,13-21H2,1H3,(H,32,33,34)/t25-/m0/s1
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n/an/a 1.97E+5n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50097409
PNG
(CHEMBL3586451)
Show SMILES Fc1ccc(cc1)-c1cnc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C17H10F4N4O/c18-11-3-1-9(2-4-11)10-5-13-15(22-6-10)14-12(7-23-24-14)16(26)25(13)8-17(19,20)21/h1-7H,8H2,(H,23,24)
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n/an/a 2.34E+5n/an/an/an/an/an/a



Structure Guided Chemistry, Dart Neuroscience LLC , 12278 Scripps Summit Drive, San Diego, California 92131, United States.

Curated by ChEMBL


Assay Description
Inhibition of human METAP2 using Met-Pro-Arg-pNa substrate by para-nitroanilide chromophore release detection assay


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435225
PNG
(CHEMBL2392892)
Show SMILES Cc1nc(nc(NC[C@H](NC(=O)CCCN2CCN(CCO)CC2)c2ccccc2)c1Cl)-c1ccccn1
Show InChI InChI=1S/C28H36ClN7O2/c1-21-26(29)28(34-27(32-21)23-10-5-6-12-30-23)31-20-24(22-8-3-2-4-9-22)33-25(38)11-7-13-35-14-16-36(17-15-35)18-19-37/h2-6,8-10,12,24,37H,7,11,13-20H2,1H3,(H,33,38)(H,31,32,34)/t24-/m0/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435223
PNG
(CHEMBL2392894)
Show SMILES Cc1nc(nc(NC[C@H](NC(=O)CCCN2CCNCC2)c2ccccc2)c1Cl)-c1ccccn1
Show InChI InChI=1S/C26H32ClN7O/c1-19-24(27)26(33-25(31-19)21-10-5-6-12-29-21)30-18-22(20-8-3-2-4-9-20)32-23(35)11-7-15-34-16-13-28-14-17-34/h2-6,8-10,12,22,28H,7,11,13-18H2,1H3,(H,32,35)(H,30,31,33)/t22-/m0/s1
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Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50097406
PNG
(CHEMBL3586454)
Show SMILES NC(=O)c1ccccc1-c1cnc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C18H12F3N5O2/c19-18(20,21)8-26-13-5-9(10-3-1-2-4-11(10)16(22)27)6-23-15(13)14-12(17(26)28)7-24-25-14/h1-7H,8H2,(H2,22,27)(H,24,25)
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n/an/a 1.02E+6n/an/an/an/an/an/a



Structure Guided Chemistry, Dart Neuroscience LLC , 12278 Scripps Summit Drive, San Diego, California 92131, United States.

Curated by ChEMBL


Assay Description
Inhibition of human METAP2 using Met-Pro-Arg-pNa substrate by para-nitroanilide chromophore release detection assay


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435191
PNG
(CHEMBL2392925)
Show SMILES Cc1nc(nc(NC[C@H](NCCCCc2ccc(Cl)cc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C28H28Cl3N5/c1-19-26(31)28(36-27(35-19)24-15-14-23(30)17-33-24)34-18-25(21-8-3-2-4-9-21)32-16-6-5-7-20-10-12-22(29)13-11-20/h2-4,8-15,17,25,32H,5-7,16,18H2,1H3,(H,34,35,36)/t25-/m0/s1
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n/an/an/an/a>3.00E+5n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435192
PNG
(CHEMBL2392924)
Show SMILES Cc1nc(nc(NC[C@H](NCCCCc2ccc(O)cc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C28H29Cl2N5O/c1-19-26(30)28(35-27(34-19)24-15-12-22(29)17-32-24)33-18-25(21-8-3-2-4-9-21)31-16-6-5-7-20-10-13-23(36)14-11-20/h2-4,8-15,17,25,31,36H,5-7,16,18H2,1H3,(H,33,34,35)/t25-/m0/s1
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n/an/an/an/a>3.00E+5n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435193
PNG
(CHEMBL2392923)
Show SMILES Cc1nc(nc(NC[C@H](NCCCCCCc2ccccc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C30H33Cl2N5/c1-22-28(32)30(37-29(36-22)26-18-17-25(31)20-34-26)35-21-27(24-15-9-5-10-16-24)33-19-11-3-2-6-12-23-13-7-4-8-14-23/h4-5,7-10,13-18,20,27,33H,2-3,6,11-12,19,21H2,1H3,(H,35,36,37)/t27-/m0/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435194
PNG
(CHEMBL2392922)
Show SMILES Cc1nc(nc(NC[C@H](NCCCCCc2ccccc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C29H31Cl2N5/c1-21-27(31)29(36-28(35-21)25-17-16-24(30)19-33-25)34-20-26(23-14-8-3-9-15-23)32-18-10-4-7-13-22-11-5-2-6-12-22/h2-3,5-6,8-9,11-12,14-17,19,26,32H,4,7,10,13,18,20H2,1H3,(H,34,35,36)/t26-/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435195
PNG
(CHEMBL2392921)
Show SMILES Cc1nc(nc(NC[C@H](NCCCCc2ccccc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C28H29Cl2N5/c1-20-26(30)28(35-27(34-20)24-16-15-23(29)18-32-24)33-19-25(22-13-6-3-7-14-22)31-17-9-8-12-21-10-4-2-5-11-21/h2-7,10-11,13-16,18,25,31H,8-9,12,17,19H2,1H3,(H,33,34,35)/t25-/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435196
PNG
(CHEMBL2392920)
Show SMILES Cc1nc(nc(NC[C@H](NCCCc2ccccc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C27H27Cl2N5/c1-19-25(29)27(34-26(33-19)23-15-14-22(28)17-31-23)32-18-24(21-12-6-3-7-13-21)30-16-8-11-20-9-4-2-5-10-20/h2-7,9-10,12-15,17,24,30H,8,11,16,18H2,1H3,(H,32,33,34)/t24-/m0/s1
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n/an/an/an/a>3.00E+5n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435197
PNG
(CHEMBL2392919)
Show SMILES Cc1nc(nc(NC[C@H](NCCc2ccccc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C26H25Cl2N5/c1-18-24(28)26(33-25(32-18)22-13-12-21(27)16-30-22)31-17-23(20-10-6-3-7-11-20)29-15-14-19-8-4-2-5-9-19/h2-13,16,23,29H,14-15,17H2,1H3,(H,31,32,33)/t23-/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435198
PNG
(CHEMBL2392918)
Show SMILES Cc1nc(nc(NC[C@H](NCc2ccccc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C25H23Cl2N5/c1-17-23(27)25(32-24(31-17)21-13-12-20(26)15-29-21)30-16-22(19-10-6-3-7-11-19)28-14-18-8-4-2-5-9-18/h2-13,15,22,28H,14,16H2,1H3,(H,30,31,32)/t22-/m0/s1
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n/an/an/an/a 3.10E+4n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435199
PNG
(CHEMBL2392917)
Show SMILES Cc1nc(nc(NC[C@H](NC(=O)CCCCCc2ccccc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C30H31Cl2N5O/c1-21-28(32)30(37-29(35-21)25-18-17-24(31)19-33-25)34-20-26(23-14-8-4-9-15-23)36-27(38)16-10-3-7-13-22-11-5-2-6-12-22/h2,4-6,8-9,11-12,14-15,17-19,26H,3,7,10,13,16,20H2,1H3,(H,36,38)(H,34,35,37)/t26-/m0/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435200
PNG
(CHEMBL2392916)
Show SMILES Cc1nc(nc(NC[C@H](NC(=O)CCCCc2ccccc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C29H29Cl2N5O/c1-20-27(31)29(36-28(34-20)24-17-16-23(30)18-32-24)33-19-25(22-13-6-3-7-14-22)35-26(37)15-9-8-12-21-10-4-2-5-11-21/h2-7,10-11,13-14,16-18,25H,8-9,12,15,19H2,1H3,(H,35,37)(H,33,34,36)/t25-/m0/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435201
PNG
(CHEMBL2392915)
Show SMILES Cc1nc(nc(NC[C@H](NC(=O)CCCc2ccccc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C28H27Cl2N5O/c1-19-26(30)28(35-27(33-19)23-16-15-22(29)17-31-23)32-18-24(21-12-6-3-7-13-21)34-25(36)14-8-11-20-9-4-2-5-10-20/h2-7,9-10,12-13,15-17,24H,8,11,14,18H2,1H3,(H,34,36)(H,32,33,35)/t24-/m0/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435202
PNG
(CHEMBL2392914)
Show SMILES Cc1nc(nc(NC[C@H](NC(=O)CCc2ccccc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C27H25Cl2N5O/c1-18-25(29)27(34-26(32-18)22-14-13-21(28)16-30-22)31-17-23(20-10-6-3-7-11-20)33-24(35)15-12-19-8-4-2-5-9-19/h2-11,13-14,16,23H,12,15,17H2,1H3,(H,33,35)(H,31,32,34)/t23-/m0/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435203
PNG
(CHEMBL2390976)
Show SMILES Cc1nc(nc(NC[C@H](NC(=O)Cc2ccccc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C26H23Cl2N5O/c1-17-24(28)26(33-25(31-17)21-13-12-20(27)15-29-21)30-16-22(19-10-6-3-7-11-19)32-23(34)14-18-8-4-2-5-9-18/h2-13,15,22H,14,16H2,1H3,(H,32,34)(H,30,31,33)/t22-/m0/s1
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n/an/an/an/a 2.80E+4n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
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