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Compile Data Set for Download or QSAR

Found 143 hits Enz. Inhib. hit(s) with Target = 'Microtubule-associated protein 2'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167916
PNG
(CHEMBL3798615)
Show SMILES FC(F)(F)c1cc(-c2cncc(c2)C#N)c2cn[nH]c2c1
Show InChI InChI=1S/C14H7F3N4/c15-14(16,17)10-2-11(12-7-20-21-13(12)3-10)9-1-8(4-18)5-19-6-9/h1-3,5-7H,(H,20,21)
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n/an/a 3n/an/an/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Reversal inhibition of full length recombinant human MetAP2 expressed in baculovirus infected insect Sf9 cells using Met-AMC as substrate measured fo...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167926
PNG
(CHEMBL3798871)
Show SMILES OCCNC(=O)c1ccc(c(F)c1)-c1cc(cc2[nH]ncc12)C(F)(F)F
Show InChI InChI=1S/C17H13F4N3O2/c18-14-5-9(16(26)22-3-4-25)1-2-11(14)12-6-10(17(19,20)21)7-15-13(12)8-23-24-15/h1-2,5-8,25H,3-4H2,(H,22,26)(H,23,24)
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n/an/a 4n/an/an/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Reversal inhibition of full length recombinant human MetAP2 expressed in baculovirus infected insect Sf9 cells using Met-AMC as substrate measured fo...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167915
PNG
(CHEMBL3798727)
Show SMILES FC(F)(F)c1cc(-c2ccc3nccn3c2)c2cn[nH]c2c1
Show InChI InChI=1S/C15H9F3N4/c16-15(17,18)10-5-11(12-7-20-21-13(12)6-10)9-1-2-14-19-3-4-22(14)8-9/h1-8H,(H,20,21)
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n/an/a 4n/an/an/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Reversal inhibition of full length recombinant human MetAP2 expressed in baculovirus infected insect Sf9 cells using Met-AMC as substrate measured fo...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167959
PNG
(CHEMBL3799242)
Show SMILES Cc1nc(ccc1-c1cc(cc2[nH]ncc12)C(F)(F)F)N1CC[C@H](O)C1
Show InChI InChI=1/C18H17F3N4O/c1-10-13(2-3-17(23-10)25-5-4-12(26)9-25)14-6-11(18(19,20)21)7-16-15(14)8-22-24-16/h2-3,6-8,12,26H,4-5,9H2,1H3,(H,22,24)/t12-/s2
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n/an/a 5n/an/an/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Reversal inhibition of full length recombinant human MetAP2 expressed in baculovirus infected insect Sf9 cells using Met-AMC as substrate measured fo...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167275
PNG
(CHEMBL3798249)
Show SMILES Clc1ccc2c(c1)n(-c1cccnc1)c1cn[nH]c21
Show InChI InChI=1S/C14H9ClN4/c15-9-3-4-11-12(6-9)19(10-2-1-5-16-7-10)13-8-17-18-14(11)13/h1-8H,(H,17,18)
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n/an/a 5n/an/an/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Inhibition of recombinant full-length human MetAP2 catalytic domain (110 to 478 residues) expressed in baculovirus using Met-AMC as substrate by fluo...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167274
PNG
(CHEMBL3797399)
Show SMILES Cc1nc2[nH]cnc2cc1-n1c2cn[nH]c2c2cc(F)ccc12
Show InChI InChI=1S/C16H11FN6/c1-8-13(5-11-16(21-8)19-7-18-11)23-12-3-2-9(17)4-10(12)15-14(23)6-20-22-15/h2-7H,1H3,(H,20,22)(H,18,19,21)
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n/an/a 5n/an/an/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Inhibition of recombinant full-length human MetAP2 catalytic domain (110 to 478 residues) expressed in baculovirus using Met-AMC as substrate by fluo...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167960
PNG
(CHEMBL3799512)
Show SMILES Cc1nc(ncc1-c1cc(cc2[nH]ncc12)C(F)(F)F)N1CC[C@@H](O)C1
Show InChI InChI=1/C17H16F3N5O/c1-9-13(6-21-16(23-9)25-3-2-11(26)8-25)12-4-10(17(18,19)20)5-15-14(12)7-22-24-15/h4-7,11,26H,2-3,8H2,1H3,(H,22,24)/t11-/s2
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n/an/a 5n/an/an/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Reversal inhibition of full length recombinant human MetAP2 expressed in baculovirus infected insect Sf9 cells using Met-AMC as substrate measured fo...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167929
PNG
(CHEMBL3798702)
Show SMILES Cc1nc(ccc1-c1cc(cc2[nH]ncc12)C(F)(F)F)N1CC[C@@H](O)C1
Show InChI InChI=1/C18H17F3N4O/c1-10-13(2-3-17(23-10)25-5-4-12(26)9-25)14-6-11(18(19,20)21)7-16-15(14)8-22-24-16/h2-3,6-8,12,26H,4-5,9H2,1H3,(H,22,24)/t12-/s2
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n/an/a 5n/an/an/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Reversal inhibition of full length recombinant human MetAP2 expressed in baculovirus infected insect Sf9 cells using Met-AMC as substrate measured fo...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167922
PNG
(CHEMBL3797286)
Show SMILES COc1ccc(c(OC)n1)-c1cc(cc2[nH]ncc12)C(F)(F)F
Show InChI InChI=1S/C15H12F3N3O2/c1-22-13-4-3-9(14(20-13)23-2)10-5-8(15(16,17)18)6-12-11(10)7-19-21-12/h3-7H,1-2H3,(H,19,21)
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n/an/a 5n/an/an/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Reversal inhibition of full length recombinant human MetAP2 expressed in baculovirus infected insect Sf9 cells using Met-AMC as substrate measured fo...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167917
PNG
(CHEMBL3797663)
Show SMILES FC(F)(F)c1cc(-c2cncnc2)c2cn[nH]c2c1
Show InChI InChI=1S/C12H7F3N4/c13-12(14,15)8-1-9(7-3-16-6-17-4-7)10-5-18-19-11(10)2-8/h1-6H,(H,18,19)
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n/an/a 6n/an/an/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Reversal inhibition of full length recombinant human MetAP2 expressed in baculovirus infected insect Sf9 cells using Met-AMC as substrate measured fo...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167961
PNG
(CHEMBL3800596)
Show SMILES Cc1nc(ncc1-c1cc(cc2[nH]ncc12)C(F)(F)F)N1CC[C@H](O)C1
Show InChI InChI=1/C17H16F3N5O/c1-9-13(6-21-16(23-9)25-3-2-11(26)8-25)12-4-10(17(18,19)20)5-15-14(12)7-22-24-15/h4-7,11,26H,2-3,8H2,1H3,(H,22,24)/t11-/s2
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n/an/a 6n/an/an/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Reversal inhibition of full length recombinant human MetAP2 expressed in baculovirus infected insect Sf9 cells using Met-AMC as substrate measured fo...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167279
PNG
(CHEMBL3799090)
Show SMILES Cc1cc(ccc1-n1c2cn[nH]c2c2cc(F)ccc12)C(=O)NCCO
Show InChI InChI=1S/C19H17FN4O2/c1-11-8-12(19(26)21-6-7-25)2-4-15(11)24-16-5-3-13(20)9-14(16)18-17(24)10-22-23-18/h2-5,8-10,25H,6-7H2,1H3,(H,21,26)(H,22,23)
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n/an/a 6.30n/an/an/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Inhibition of recombinant full-length human MetAP2 catalytic domain (110 to 478 residues) expressed in baculovirus using Met-AMC as substrate by fluo...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167280
PNG
(CHEMBL3797259)
Show SMILES OCCNC(=O)c1ccc(cc1)-n1c2cn[nH]c2c2cc(F)ccc12
Show InChI InChI=1S/C18H15FN4O2/c19-12-3-6-15-14(9-12)17-16(10-21-22-17)23(15)13-4-1-11(2-5-13)18(25)20-7-8-24/h1-6,9-10,24H,7-8H2,(H,20,25)(H,21,22)
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n/an/a 6.30n/an/an/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Inhibition of recombinant full-length human MetAP2 catalytic domain (110 to 478 residues) expressed in baculovirus using Met-AMC as substrate by fluo...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167276
PNG
(CHEMBL3798844)
Show SMILES Fc1cc2n(-c3cccnc3)c3cn[nH]c3c2cc1F
Show InChI InChI=1S/C14H8F2N4/c15-10-4-9-12(5-11(10)16)20(8-2-1-3-17-6-8)13-7-18-19-14(9)13/h1-7H,(H,18,19)
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n/an/a 7.90n/an/an/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Inhibition of recombinant full-length human MetAP2 catalytic domain (110 to 478 residues) expressed in baculovirus using Met-AMC as substrate by fluo...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167278
PNG
(CHEMBL3800236)
Show SMILES Nc1ncc(cc1Cl)-n1c2cn[nH]c2c2cc(F)ccc12
Show InChI InChI=1S/C14H9ClFN5/c15-10-4-8(5-18-14(10)17)21-11-2-1-7(16)3-9(11)13-12(21)6-19-20-13/h1-6H,(H2,17,18)(H,19,20)
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n/an/a 7.90n/an/an/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Inhibition of recombinant full-length human MetAP2 catalytic domain (110 to 478 residues) expressed in baculovirus using Met-AMC as substrate by fluo...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167919
PNG
(CHEMBL3799449)
Show SMILES COc1cnccc1-c1cc(cc2[nH]ncc12)C(F)(F)F
Show InChI InChI=1S/C14H10F3N3O/c1-21-13-7-18-3-2-9(13)10-4-8(14(15,16)17)5-12-11(10)6-19-20-12/h2-7H,1H3,(H,19,20)
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n/an/a 8n/an/an/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Reversal inhibition of full length recombinant human MetAP2 expressed in baculovirus infected insect Sf9 cells using Met-AMC as substrate measured fo...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167920
PNG
(CHEMBL3800546)
Show SMILES Fc1cnccc1-c1cc(cc2[nH]ncc12)C(F)(F)F
Show InChI InChI=1S/C13H7F4N3/c14-11-6-18-2-1-8(11)9-3-7(13(15,16)17)4-12-10(9)5-19-20-12/h1-6H,(H,19,20)
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n/an/a 8n/an/an/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Reversal inhibition of full length recombinant human MetAP2 expressed in baculovirus infected insect Sf9 cells using Met-AMC as substrate measured fo...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167921
PNG
(CHEMBL3800534)
Show SMILES COc1ncc(c(OC)n1)-c1cc(cc2[nH]ncc12)C(F)(F)F
Show InChI InChI=1S/C14H11F3N4O2/c1-22-12-10(5-18-13(20-12)23-2)8-3-7(14(15,16)17)4-11-9(8)6-19-21-11/h3-6H,1-2H3,(H,19,21)
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n/an/a 8n/an/an/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Reversal inhibition of full length recombinant human MetAP2 expressed in baculovirus infected insect Sf9 cells using Met-AMC as substrate measured fo...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167918
PNG
(CHEMBL3799467)
Show SMILES Cn1nccc1-c1cc(cc2[nH]ncc12)C(F)(F)F
Show InChI InChI=1S/C12H9F3N4/c1-19-11(2-3-17-19)8-4-7(12(13,14)15)5-10-9(8)6-16-18-10/h2-6H,1H3,(H,16,18)
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n/an/a 9n/an/an/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Reversal inhibition of full length recombinant human MetAP2 expressed in baculovirus infected insect Sf9 cells using Met-AMC as substrate measured fo...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167923
PNG
(CHEMBL3797707)
Show SMILES COc1nc(N)ncc1-c1cc(cc2[nH]ncc12)C(F)(F)F
Show InChI InChI=1S/C13H10F3N5O/c1-22-11-9(4-18-12(17)20-11)7-2-6(13(14,15)16)3-10-8(7)5-19-21-10/h2-5H,1H3,(H,19,21)(H2,17,18,20)
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n/an/a 10n/an/an/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Reversal inhibition of full length recombinant human MetAP2 expressed in baculovirus infected insect Sf9 cells using Met-AMC as substrate measured fo...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167281
PNG
(CHEMBL3799796)
Show SMILES Cc1nc2n(C)cnc2cc1-n1c2cn[nH]c2c2cc(F)ccc12
Show InChI InChI=1S/C17H13FN6/c1-9-14(6-12-17(21-9)23(2)8-19-12)24-13-4-3-10(18)5-11(13)16-15(24)7-20-22-16/h3-8H,1-2H3,(H,20,22)
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n/an/a 10n/an/an/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Inhibition of recombinant full-length human MetAP2 catalytic domain (110 to 478 residues) expressed in baculovirus using Met-AMC as substrate by fluo...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167285
PNG
(CHEMBL3797780)
Show SMILES Cc1c(cnc2[nH]cnc12)-n1c2cn[nH]c2c2cc(F)ccc12
Show InChI InChI=1S/C16H11FN6/c1-8-12(5-18-16-14(8)19-7-20-16)23-11-3-2-9(17)4-10(11)15-13(23)6-21-22-15/h2-7H,1H3,(H,21,22)(H,18,19,20)
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n/an/a 10n/an/an/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Inhibition of recombinant full-length human MetAP2 catalytic domain (110 to 478 residues) expressed in baculovirus using Met-AMC as substrate by fluo...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167914
PNG
(CHEMBL3798034)
Show SMILES Cc1cnccc1-c1cc(cc2[nH]ncc12)C(F)(F)F
Show InChI InChI=1S/C14H10F3N3/c1-8-6-18-3-2-10(8)11-4-9(14(15,16)17)5-13-12(11)7-19-20-13/h2-7H,1H3,(H,19,20)
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n/an/a 11n/an/an/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Reversal inhibition of full length recombinant human MetAP2 expressed in baculovirus infected insect Sf9 cells using Met-AMC as substrate measured fo...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167927
PNG
(CHEMBL3800090)
Show SMILES Cc1cc(ccc1-c1cc(cc2[nH]ncc12)C(F)(F)F)C(=O)NCCO
Show InChI InChI=1S/C18H16F3N3O2/c1-10-6-11(17(26)22-4-5-25)2-3-13(10)14-7-12(18(19,20)21)8-16-15(14)9-23-24-16/h2-3,6-9,25H,4-5H2,1H3,(H,22,26)(H,23,24)
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n/an/a 11n/an/an/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Reversal inhibition of full length recombinant human MetAP2 expressed in baculovirus infected insect Sf9 cells using Met-AMC as substrate measured fo...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167925
PNG
(CHEMBL3798047)
Show SMILES COc1cc(ccc1-c1cc(cc2[nH]ncc12)C(F)(F)F)C(=O)NCCO
Show InChI InChI=1S/C18H16F3N3O3/c1-27-16-6-10(17(26)22-4-5-25)2-3-12(16)13-7-11(18(19,20)21)8-15-14(13)9-23-24-15/h2-3,6-9,25H,4-5H2,1H3,(H,22,26)(H,23,24)
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n/an/a 13n/an/an/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Reversal inhibition of full length recombinant human MetAP2 expressed in baculovirus infected insect Sf9 cells using Met-AMC as substrate measured fo...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167277
PNG
(CHEMBL3797386)
Show SMILES Fc1ccc2n(-c3cccnc3)c3cn[nH]c3c2c1
Show InChI InChI=1S/C14H9FN4/c15-9-3-4-12-11(6-9)14-13(8-17-18-14)19(12)10-2-1-5-16-7-10/h1-8H,(H,17,18)
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n/an/a 13n/an/an/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Inhibition of recombinant full-length human MetAP2 catalytic domain (110 to 478 residues) expressed in baculovirus using Met-AMC as substrate by fluo...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167924
PNG
(CHEMBL3798381)
Show SMILES CNC(=O)c1ccc(c(OC)c1)-c1cc(cc2[nH]ncc12)C(F)(F)F
Show InChI InChI=1S/C17H14F3N3O2/c1-21-16(24)9-3-4-11(15(5-9)25-2)12-6-10(17(18,19)20)7-14-13(12)8-22-23-14/h3-8H,1-2H3,(H,21,24)(H,22,23)
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n/an/a 15n/an/an/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Reversal inhibition of full length recombinant human MetAP2 expressed in baculovirus infected insect Sf9 cells using Met-AMC as substrate measured fo...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167909
PNG
(CHEMBL3798509)
Show SMILES FC(F)(F)c1cc(-c2ccccc2)c2cn[nH]c2c1
Show InChI InChI=1S/C14H9F3N2/c15-14(16,17)10-6-11(9-4-2-1-3-5-9)12-8-18-19-13(12)7-10/h1-8H,(H,18,19)
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n/an/a 20n/an/an/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Reversal inhibition of full length recombinant human MetAP2 expressed in baculovirus infected insect Sf9 cells using Met-AMC as substrate measured fo...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167928
PNG
(CHEMBL3797699)
Show SMILES Cc1cc(ncc1-c1cc(cc2[nH]ncc12)C(F)(F)F)C(=O)NCCO
Show InChI InChI=1S/C17H15F3N4O2/c1-9-4-15(16(26)21-2-3-25)22-7-12(9)11-5-10(17(18,19)20)6-14-13(11)8-23-24-14/h4-8,25H,2-3H2,1H3,(H,21,26)(H,23,24)
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n/an/a 21n/an/an/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Reversal inhibition of full length recombinant human MetAP2 expressed in baculovirus infected insect Sf9 cells using Met-AMC as substrate measured fo...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167320
PNG
(CHEMBL3797508)
Show SMILES FC(F)(F)c1ccc2cn[nH]c2c1
Show InChI InChI=1S/C8H5F3N2/c9-8(10,11)6-2-1-5-4-12-13-7(5)3-6/h1-4H,(H,12,13)
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n/an/a 50n/an/an/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Inhibition of recombinant full-length human MetAP2 catalytic domain (110 to 478 residues) expressed in baculovirus using Met-AMC as substrate by fluo...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167910
PNG
(CHEMBL3798100)
Show SMILES N#Cc1cc(-c2ccccc2)c2cn[nH]c2c1
Show InChI InChI=1S/C14H9N3/c15-8-10-6-12(11-4-2-1-3-5-11)13-9-16-17-14(13)7-10/h1-7,9H,(H,16,17)
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n/an/a 62n/an/an/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Reversal inhibition of full length recombinant human MetAP2 expressed in baculovirus infected insect Sf9 cells using Met-AMC as substrate measured fo...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167904
PNG
(CHEMBL3799496)
Show SMILES Clc1cc(-c2ccccc2)c2cn[nH]c2c1
Show InChI InChI=1S/C13H9ClN2/c14-10-6-11(9-4-2-1-3-5-9)12-8-15-16-13(12)7-10/h1-8H,(H,15,16)
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n/an/a 79n/an/an/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Reversal inhibition of full length recombinant human MetAP2 expressed in baculovirus infected insect Sf9 cells using Met-AMC as substrate measured fo...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167318
PNG
(CHEMBL3797789)
Show SMILES Fc1ccc2[nH]c3cn[nH]c3c2c1
Show InChI InChI=1S/C9H6FN3/c10-5-1-2-7-6(3-5)9-8(12-7)4-11-13-9/h1-4,12H,(H,11,13)
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n/an/a 79n/an/an/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Inhibition of recombinant full-length human MetAP2 catalytic domain (110 to 478 residues) expressed in baculovirus using Met-AMC as substrate by fluo...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167913
PNG
(CHEMBL3798443)
Show SMILES FC(F)(F)Oc1cc(-c2ccccc2)c2cn[nH]c2c1
Show InChI InChI=1S/C14H9F3N2O/c15-14(16,17)20-10-6-11(9-4-2-1-3-5-9)12-8-18-19-13(12)7-10/h1-8H,(H,18,19)
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n/an/a 91n/an/an/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Reversal inhibition of full length recombinant human MetAP2 expressed in baculovirus infected insect Sf9 cells using Met-AMC as substrate measured fo...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167907
PNG
(CHEMBL3798111)
Show SMILES Cc1cc(-c2ccccc2)c2cn[nH]c2c1
Show InChI InChI=1S/C14H12N2/c1-10-7-12(11-5-3-2-4-6-11)13-9-15-16-14(13)8-10/h2-9H,1H3,(H,15,16)
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n/an/a 220n/an/an/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Reversal inhibition of full length recombinant human MetAP2 expressed in baculovirus infected insect Sf9 cells using Met-AMC as substrate measured fo...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167912
PNG
(CHEMBL3799532)
Show SMILES CS(=O)(=O)c1cc(-c2ccccc2)c2cn[nH]c2c1
Show InChI InChI=1S/C14H12N2O2S/c1-19(17,18)11-7-12(10-5-3-2-4-6-10)13-9-15-16-14(13)8-11/h2-9H,1H3,(H,15,16)
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n/an/a 360n/an/an/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Reversal inhibition of full length recombinant human MetAP2 expressed in baculovirus infected insect Sf9 cells using Met-AMC as substrate measured fo...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167911
PNG
(CHEMBL3799684)
Show SMILES CC(C)c1cc(-c2ccccc2)c2cn[nH]c2c1
Show InChI InChI=1S/C16H16N2/c1-11(2)13-8-14(12-6-4-3-5-7-12)15-10-17-18-16(15)9-13/h3-11H,1-2H3,(H,17,18)
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n/an/a 550n/an/an/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Reversal inhibition of full length recombinant human MetAP2 expressed in baculovirus infected insect Sf9 cells using Met-AMC as substrate measured fo...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167908
PNG
(CHEMBL3799625)
Show SMILES COc1cc(-c2ccccc2)c2cn[nH]c2c1
Show InChI InChI=1S/C14H12N2O/c1-17-11-7-12(10-5-3-2-4-6-10)13-9-15-16-14(13)8-11/h2-9H,1H3,(H,15,16)
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n/an/a 730n/an/an/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Reversal inhibition of full length recombinant human MetAP2 expressed in baculovirus infected insect Sf9 cells using Met-AMC as substrate measured fo...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167906
PNG
(CHEMBL3798664)
Show SMILES Fc1cc(-c2ccccc2)c2cn[nH]c2c1
Show InChI InChI=1S/C13H9FN2/c14-10-6-11(9-4-2-1-3-5-9)12-8-15-16-13(12)7-10/h1-8H,(H,15,16)
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n/an/a 960n/an/an/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Reversal inhibition of full length recombinant human MetAP2 expressed in baculovirus infected insect Sf9 cells using Met-AMC as substrate measured fo...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167319
PNG
(CHEMBL3797549)
Show SMILES c1n[nH]c2c1[nH]c1ccccc21
Show InChI InChI=1S/C9H7N3/c1-2-4-7-6(3-1)9-8(11-7)5-10-12-9/h1-5,11H,(H,10,12)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Inhibition of recombinant full-length human MetAP2 catalytic domain (110 to 478 residues) expressed in baculovirus using Met-AMC as substrate by fluo...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50209237
PNG
(6-bromo-1H-indazole | CHEMBL247365)
Show SMILES Brc1ccc2cn[nH]c2c1
Show InChI InChI=1S/C7H5BrN2/c8-6-2-1-5-4-9-10-7(5)3-6/h1-4H,(H,9,10)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Reversal inhibition of full length recombinant human MetAP2 expressed in baculovirus infected insect Sf9 cells using Met-AMC as substrate measured fo...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167901
PNG
(CHEMBL3798369)
Show SMILES Oc1n[nH]c2cc(Br)ccc12
Show InChI InChI=1S/C7H5BrN2O/c8-4-1-2-5-6(3-4)9-10-7(5)11/h1-3H,(H2,9,10,11)
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n/an/a 2.80E+3n/an/an/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Reversal inhibition of full length recombinant human MetAP2 expressed in baculovirus infected insect Sf9 cells using Met-AMC as substrate measured fo...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50097408
PNG
(CHEMBL3586452)
Show SMILES Cc1ccccc1-c1cnc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C18H13F3N4O/c1-10-4-2-3-5-12(10)11-6-14-16(22-7-11)15-13(8-23-24-15)17(26)25(14)9-18(19,20)21/h2-8H,9H2,1H3,(H,23,24)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Structure Guided Chemistry, Dart Neuroscience LLC , 12278 Scripps Summit Drive, San Diego, California 92131, United States.

Curated by ChEMBL


Assay Description
Inhibition of human METAP2 using Met-Pro-Arg-pNa substrate by para-nitroanilide chromophore release detection assay


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50097405
PNG
(CHEMBL3586455)
Show SMILES CNS(=O)(=O)c1ccccc1-c1cnc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C18H14F3N5O3S/c1-22-30(28,29)14-5-3-2-4-11(14)10-6-13-16(23-7-10)15-12(8-24-25-15)17(27)26(13)9-18(19,20)21/h2-8,22H,9H2,1H3,(H,24,25)
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n/an/a 4.00E+3n/an/an/an/an/an/a



Structure Guided Chemistry, Dart Neuroscience LLC , 12278 Scripps Summit Drive, San Diego, California 92131, United States.

Curated by ChEMBL


Assay Description
Inhibition of human METAP2 using Met-Pro-Arg-pNa substrate by para-nitroanilide chromophore release detection assay


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50097403
PNG
(CHEMBL3586457)
Show SMILES CN1CCN(CC1)c1ccc(cn1)-c1cnc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C21H20F3N7O/c1-29-4-6-30(7-5-29)17-3-2-13(9-25-17)14-8-16-19(26-10-14)18-15(11-27-28-18)20(32)31(16)12-21(22,23)24/h2-3,8-11H,4-7,12H2,1H3,(H,27,28)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Structure Guided Chemistry, Dart Neuroscience LLC , 12278 Scripps Summit Drive, San Diego, California 92131, United States.

Curated by ChEMBL


Assay Description
Inhibition of human METAP2 using Met-Pro-Arg-pNa substrate by para-nitroanilide chromophore release detection assay


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167905
PNG
(CHEMBL3799845)
Show SMILES c1n[nH]c2cccc(-c3ccccc3)c12
Show InChI InChI=1S/C13H10N2/c1-2-5-10(6-3-1)11-7-4-8-13-12(11)9-14-15-13/h1-9H,(H,14,15)
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n/an/a 5.50E+3n/an/an/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Reversal inhibition of full length recombinant human MetAP2 expressed in baculovirus infected insect Sf9 cells using Met-AMC as substrate measured fo...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50097404
PNG
(CHEMBL3586456)
Show SMILES CS(=O)(=O)Nc1ccccc1-c1cnc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C18H14F3N5O3S/c1-30(28,29)25-13-5-3-2-4-11(13)10-6-14-16(22-7-10)15-12(8-23-24-15)17(27)26(14)9-18(19,20)21/h2-8,25H,9H2,1H3,(H,23,24)
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n/an/a 8.00E+3n/an/an/an/an/an/a



Structure Guided Chemistry, Dart Neuroscience LLC , 12278 Scripps Summit Drive, San Diego, California 92131, United States.

Curated by ChEMBL


Assay Description
Inhibition of human METAP2 using Met-Pro-Arg-pNa substrate by para-nitroanilide chromophore release detection assay


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50433375
PNG
(CHEMBL472879 | GNF-Pf-359)
Show SMILES Cc1nc(nc(NCCc2ccccc2)c1Cl)-c1ccccn1
Show InChI InChI=1S/C18H17ClN4/c1-13-16(19)18(21-12-10-14-7-3-2-4-8-14)23-17(22-13)15-9-5-6-11-20-15/h2-9,11H,10,12H2,1H3,(H,21,22,23)
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n/an/a 9.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


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Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435218
PNG
(CHEMBL2392899)
Show SMILES Cc1nc(nc(NC[C@H](NS(=O)(=O)CCN2CCNCC2)c2ccccc2)c1Cl)-c1ccccn1
Show InChI InChI=1S/C24H30ClN7O2S/c1-18-22(25)24(30-23(29-18)20-9-5-6-10-27-20)28-17-21(19-7-3-2-4-8-19)31-35(33,34)16-15-32-13-11-26-12-14-32/h2-10,21,26,31H,11-17H2,1H3,(H,28,29,30)/t21-/m0/s1
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n/an/a 9.40E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50097412
PNG
(CHEMBL3586448)
Show SMILES FC(F)(F)Cn1c2cc(cnc2c2[nH]ncc2c1=O)-c1cccnc1Cl
Show InChI InChI=1S/C16H9ClF3N5O/c17-14-9(2-1-3-21-14)8-4-11-13(22-5-8)12-10(6-23-24-12)15(26)25(11)7-16(18,19)20/h1-6H,7H2,(H,23,24)
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n/an/a 1.10E+4n/an/an/an/an/an/a



Structure Guided Chemistry, Dart Neuroscience LLC , 12278 Scripps Summit Drive, San Diego, California 92131, United States.

Curated by ChEMBL


Assay Description
Inhibition of human METAP2 using Met-Pro-Arg-pNa substrate by para-nitroanilide chromophore release detection assay


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