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Compile Data Set for Download or QSAR

Found 163 hits Enz. Inhib. hit(s) with Target = 'Microtubule-associated protein tau'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tau


(Homo sapiens (Human))
BDBM50020865
PNG
(CHEMBL3286988)
Show SMILES COc1cc(\C=c2/sc3nc(cn3c2=O)-c2cccc(Cl)c2)cc(OC)c1O
Show InChI InChI=1S/C20H15ClN2O4S/c1-26-15-6-11(7-16(27-2)18(15)24)8-17-19(25)23-10-14(22-20(23)28-17)12-4-3-5-13(21)9-12/h3-10,24H,1-2H3/b17-8-
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n/an/a 1n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human microtubule associated protein tau aggregation by Thiazin-red R displacement fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM50402408
PNG
(CHEMBL2203332)
Show SMILES CCCC[N+]1=C(\C=C\c2ccc(cc2)N(CC)CC)C(C)(C)c2ccccc12
Show InChI InChI=1S/C26H35N2/c1-6-9-20-28-24-13-11-10-12-23(24)26(4,5)25(28)19-16-21-14-17-22(18-15-21)27(7-2)8-3/h10-19H,6-9,20H2,1-5H3/q+1
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n/an/a 1.41n/an/an/an/an/an/a



Technische Universit£t Darmstadt

Curated by ChEMBL


Assay Description
Displacement of thiazine red R from human Tau aggregate expressed in Escherichia coli after 30 mins by fluorimetric analysis


Citation and Details
More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM50020859
PNG
(CHEMBL3286982)
Show SMILES COc1cc(\C=c2/sc3nc(cn3c2=O)-c2ccc(Cl)cc2)cc(OC)c1O
Show InChI InChI=1S/C20H15ClN2O4S/c1-26-15-7-11(8-16(27-2)18(15)24)9-17-19(25)23-10-14(22-20(23)28-17)12-3-5-13(21)6-4-12/h3-10,24H,1-2H3/b17-9-
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n/an/a 2n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human microtubule associated protein tau aggregation by Thiazin-red R displacement fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM50020860
PNG
(CHEMBL3286983)
Show SMILES COc1cc(\C=c2/sc3nc(cn3c2=O)-c2ccc(Cl)cc2)cc(Cl)c1O
Show InChI InChI=1S/C19H12Cl2N2O3S/c1-26-15-7-10(6-13(21)17(15)24)8-16-18(25)23-9-14(22-19(23)27-16)11-2-4-12(20)5-3-11/h2-9,24H,1H3/b16-8-
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n/an/a 2n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human microtubule associated protein tau aggregation by Thiazin-red R displacement fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM50020861
PNG
(CHEMBL3286984)
Show SMILES COc1cc(\C=c2/sc3nc(cn3c2=O)-c2ccc(Cl)cc2)cc(Br)c1O
Show InChI InChI=1S/C19H12BrClN2O3S/c1-26-15-7-10(6-13(20)17(15)24)8-16-18(25)23-9-14(22-19(23)27-16)11-2-4-12(21)5-3-11/h2-9,24H,1H3/b16-8-
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n/an/a 2n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human microtubule associated protein tau aggregation by Thiazin-red R displacement fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM50398204
PNG
(CHEMBL2181532)
Show SMILES C1CCN(C1)c1ccc(\C=C\c2cc(\C=C\c3ccc(cc3)N3CCCC3)ncn2)cc1
Show InChI InChI=1S/C28H30N4/c1-2-18-31(17-1)27-13-7-23(8-14-27)5-11-25-21-26(30-22-29-25)12-6-24-9-15-28(16-10-24)32-19-3-4-20-32/h5-16,21-22H,1-4,17-20H2/b11-5+,12-6+
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n/an/a 2n/an/an/an/an/an/a



Technische Universit£t Darmstadt

Curated by ChEMBL


Assay Description
Displacement of thiazene red from tau aggregate


Citation and Details
More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM50398203
PNG
(CHEMBL2181533)
Show SMILES CN(C)c1ccc(\C=C\C=C\c2cc(\C=C\C=C\c3ccc(cc3)N(C)C)ncn2)cc1
Show InChI InChI=1S/C28H30N4/c1-31(2)27-17-13-23(14-18-27)9-5-7-11-25-21-26(30-22-29-25)12-8-6-10-24-15-19-28(20-16-24)32(3)4/h5-22H,1-4H3/b9-5+,10-6+,11-7+,12-8+
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n/an/a 2n/an/an/an/an/an/a



Technische Universit£t Darmstadt

Curated by ChEMBL


Assay Description
Displacement of thiazene red from tau aggregate


Citation and Details
More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM50020867
PNG
(CHEMBL3286989)
Show SMILES COc1cc(\C=c2/sc3nc(cn3c2=O)-c2cccc(c2)C(F)(F)F)cc(Cl)c1O
Show InChI InChI=1S/C20H12ClF3N2O3S/c1-29-15-6-10(5-13(21)17(15)27)7-16-18(28)26-9-14(25-19(26)30-16)11-3-2-4-12(8-11)20(22,23)24/h2-9,27H,1H3/b16-7-
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n/an/a 3n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human microtubule associated protein tau aggregation by Thiazin-red R displacement fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM50398207
PNG
(CHEMBL2181045)
Show SMILES CN(C)c1ccc(\C=C\c2cc(\C=C\c3ccc(cc3)N(C)C)ncn2)cc1
Show InChI InChI=1S/C24H26N4/c1-27(2)23-13-7-19(8-14-23)5-11-21-17-22(26-18-25-21)12-6-20-9-15-24(16-10-20)28(3)4/h5-18H,1-4H3/b11-5+,12-6+
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n/an/a 4n/an/an/an/an/an/a



Technische Universit£t Darmstadt

Curated by ChEMBL


Assay Description
Displacement of thiazene red from tau aggregate


Citation and Details
More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM50020858
PNG
(CHEMBL3286981)
Show SMILES COc1cc(\C=c2/sc3nc(cn3c2=O)-c2ccncc2)cc(OC)c1O
Show InChI InChI=1S/C19H15N3O4S/c1-25-14-7-11(8-15(26-2)17(14)23)9-16-18(24)22-10-13(21-19(22)27-16)12-3-5-20-6-4-12/h3-10,23H,1-2H3/b16-9-
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n/an/a 5n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human microtubule associated protein tau aggregation by Thiazin-red R displacement fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM50020862
PNG
(CHEMBL3286985)
Show SMILES COc1cc(\C=c2/sc3nc(cn3c2=O)-c2ccc(Cl)cc2)cc(O)c1O
Show InChI InChI=1S/C19H13ClN2O4S/c1-26-15-7-10(6-14(23)17(15)24)8-16-18(25)22-9-13(21-19(22)27-16)11-2-4-12(20)5-3-11/h2-9,23-24H,1H3/b16-8-
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n/an/a 5n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human microtubule associated protein tau aggregation by Thiazin-red R displacement fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM50402407
PNG
(CHEMBL2207756)
Show SMILES C[N+]1=C(\C=C\c2ccc(cc2)N2CCCC2)C(C)(C)c2ccccc12
Show InChI InChI=1S/C23H27N2/c1-23(2)20-8-4-5-9-21(20)24(3)22(23)15-12-18-10-13-19(14-11-18)25-16-6-7-17-25/h4-5,8-15H,6-7,16-17H2,1-3H3/q+1
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n/an/a 5.10n/an/an/an/an/an/a



Technische Universit£t Darmstadt

Curated by ChEMBL


Assay Description
Displacement of thiazine red R from human Tau aggregate expressed in Escherichia coli after 30 mins by fluorimetric analysis


Citation and Details
More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM50398209
PNG
(CHEMBL2181041)
Show SMILES C1CN(CCO1)c1ccc(\C=C\c2cnc(\C=C\c3ccc(cc3)N3CCOCC3)cn2)cc1
Show InChI InChI=1S/C28H30N4O2/c1(23-3-9-27(10-4-23)31-13-17-33-18-14-31)7-25-21-30-26(22-29-25)8-2-24-5-11-28(12-6-24)32-15-19-34-20-16-32/h1-12,21-22H,13-20H2/b7-1+,8-2+
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n/an/a 6n/an/an/an/an/an/a



Technische Universit£t Darmstadt

Curated by ChEMBL


Assay Description
Displacement of thiazene red from tau aggregate


Citation and Details
More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM50020864
PNG
(CHEMBL3286987)
Show SMILES COc1cc(\C=c2/sc3nc(cn3c2=O)-c2ccncc2C)cc(OC)c1O
Show InChI InChI=1S/C20H17N3O4S/c1-11-9-21-5-4-13(11)14-10-23-19(25)17(28-20(23)22-14)8-12-6-15(26-2)18(24)16(7-12)27-3/h4-10,24H,1-3H3/b17-8-
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n/an/a 8n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human microtubule associated protein tau aggregation by Thiazin-red R displacement fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM50020869
PNG
(CHEMBL3286990)
Show SMILES COc1cc(\C=c2/sc3nc(cn3c2=O)-c2cccc(OC(F)(F)F)c2)cc(F)c1O
Show InChI InChI=1S/C20H12F4N2O4S/c1-29-15-6-10(5-13(21)17(15)27)7-16-18(28)26-9-14(25-19(26)31-16)11-3-2-4-12(8-11)30-20(22,23)24/h2-9,27H,1H3/b16-7-
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n/an/a 13n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human microtubule associated protein tau aggregation by Thiazin-red R displacement fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM50398210
PNG
(CHEMBL2181039)
Show SMILES COc1ccc(\C=C\c2cnc(\C=C\c3ccc(OC)cc3)cn2)cc1
Show InChI InChI=1S/C22H20N2O2/c1-25-21-11-5-17(6-12-21)3-9-19-15-24-20(16-23-19)10-4-18-7-13-22(26-2)14-8-18/h3-16H,1-2H3/b9-3+,10-4+
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n/an/a 13n/an/an/an/an/an/a



Technische Universit£t Darmstadt

Curated by ChEMBL


Assay Description
Displacement of thiazene red from tau aggregate


Citation and Details
More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM50398205
PNG
(CHEMBL2181531)
Show SMILES C1CCN(CC1)c1ccc(\C=C\c2cc(\C=C\c3ccc(cc3)N3CCCCC3)ncn2)cc1
Show InChI InChI=1S/C30H34N4/c1-3-19-33(20-4-1)29-15-9-25(10-16-29)7-13-27-23-28(32-24-31-27)14-8-26-11-17-30(18-12-26)34-21-5-2-6-22-34/h7-18,23-24H,1-6,19-22H2/b13-7+,14-8+
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n/an/a 17n/an/an/an/an/an/a



Technische Universit£t Darmstadt

Curated by ChEMBL


Assay Description
Displacement of thiazene red from tau aggregate


Citation and Details
More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM50398208
PNG
(CHEMBL2181042)
Show SMILES CN1CCN(CC1)c1ccc(\C=C\c2cnc(\C=C\c3ccc(cc3)N3CCN(C)CC3)cn2)cc1
Show InChI InChI=1S/C30H36N6/c1-33-15-19-35(20-16-33)29-11-5-25(6-12-29)3-9-27-23-32-28(24-31-27)10-4-26-7-13-30(14-8-26)36-21-17-34(2)18-22-36/h3-14,23-24H,15-22H2,1-2H3/b9-3+,10-4+
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n/an/a 42n/an/an/an/an/an/a



Technische Universit£t Darmstadt

Curated by ChEMBL


Assay Description
Displacement of thiazene red from tau aggregate


Citation and Details
More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM50434371
PNG
(AZURE A | Azure A (12))
Show SMILES C[N+](C)=c1ccc2nc3ccc(N)cc3sc2c1
Show InChI InChI=1S/C14H13N3S/c1-17(2)10-4-6-12-14(8-10)18-13-7-9(15)3-5-11(13)16-12/h3-8,15H,1-2H3/p+1
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n/an/a 69n/an/an/an/an/an/a



Humboldt-Universit£t zu Berlin

Curated by ChEMBL


Assay Description
Inhibition of tau protein aggregation (unknown origin) at 5:1 compound to protein concentration by Western blot analysis


Citation and Details
More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM50434370
PNG
(CHEMBL593252 | GNF-Pf-3564 | Thionin (14))
Show SMILES Nc1ccc2nc3ccc(=[NH2+])cc3sc2c1
Show InChI InChI=1S/C12H9N3S/c13-7-1-3-9-11(5-7)16-12-6-8(14)2-4-10(12)15-9/h1-6,13H,14H2/p+1
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n/an/a 69n/an/an/an/an/an/a



Humboldt-Universit£t zu Berlin

Curated by ChEMBL


Assay Description
Inhibition of tau protein aggregation (unknown origin) at 5:1 compound to protein concentration by Western blot analysis


Citation and Details
More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM50430742
PNG
(Blutene | TOLONIUM CHLORIDE | Toluidine Blue O)
Show SMILES Cc1cc2nc3ccc(cc3sc2cc1N)=[N+](C)C
Show InChI InChI=1S/C15H15N3S/c1-9-6-13-15(8-11(9)16)19-14-7-10(18(2)3)4-5-12(14)17-13/h4-8,16H,1-3H3/p+1
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n/an/a 69n/an/an/an/an/an/a



Humboldt-Universit£t zu Berlin

Curated by ChEMBL


Assay Description
Inhibition of tau protein aggregation (unknown origin) at 5:1 compound to protein concentration by Western blot analysis


Citation and Details
More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM50020863
PNG
(CHEMBL3286986)
Show SMILES COc1cc(\C=c2/sc3nc(cn3c2=O)-c2ccncc2C)ccc1O
Show InChI InChI=1S/C19H15N3O3S/c1-11-9-20-6-5-13(11)14-10-22-18(24)17(26-19(22)21-14)8-12-3-4-15(23)16(7-12)25-2/h3-10,23H,1-2H3/b17-8-
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n/an/a 79n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human microtubule associated protein tau aggregation by Thiazin-red R displacement fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM50434366
PNG
(CHEMBL1789430)
Show SMILES C1CCN2\C(Sc3ccccc23)=C\C=C\c2sc3ccccc3[n+]2CCCCCN2\C(Sc3ccccc23)=C\C=C\c2sc3ccccc3[n+]2CC1
Show InChI InChI=1S/C44H42N4S4/c1-11-29-45-33-17-3-7-21-37(33)49-41(45)25-15-27-43-47(35-19-5-9-23-39(35)51-43)31-13-2-14-32-48-36-20-6-10-24-40(36)52-44(48)28-16-26-42-46(30-12-1)34-18-4-8-22-38(34)50-42/h3-10,15-28H,1-2,11-14,29-32H2/q+2
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n/an/a 80n/an/an/an/an/an/a



Humboldt-Universit£t zu Berlin

Curated by ChEMBL


Assay Description
Inhibition of tau protein aggregation (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM50398211
PNG
(CHEMBL2181036)
Show SMILES COc1cc(\C=C\c2ccc(O)cc2)ccc1\C=C\c1ccc(O)cc1
Show InChI InChI=1S/C23H20O3/c1-26-23-16-19(3-2-17-6-12-21(24)13-7-17)5-11-20(23)10-4-18-8-14-22(25)15-9-18/h2-16,24-25H,1H3/b3-2+,10-4+
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n/an/a 246n/an/an/an/an/an/a



Technische Universit£t Darmstadt

Curated by ChEMBL


Assay Description
Displacement of thiazene red from tau aggregate


Citation and Details
More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM50398211
PNG
(CHEMBL2181036)
Show SMILES COc1cc(\C=C\c2ccc(O)cc2)ccc1\C=C\c1ccc(O)cc1
Show InChI InChI=1S/C23H20O3/c1-26-23-16-19(3-2-17-6-12-21(24)13-7-17)5-11-20(23)10-4-18-8-14-22(25)15-9-18/h2-16,24-25H,1H3/b3-2+,10-4+
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n/an/a 246n/an/an/an/an/an/a



Technische Universit£t Darmstadt

Curated by ChEMBL


Assay Description
Displacement of thiazine red R from human Tau aggregate expressed in Escherichia coli after 30 mins by fluorimetric analysis


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Rattus norvegicus)
BDBM50313696
PNG
(CHEMBL1086427 | N-(6-chloro-7-fluoro-5-phenyl-1H-i...)
Show SMILES CCCC(=O)Nc1n[nH]c2c(F)c(Cl)c(cc12)-c1ccccc1
Show InChI InChI=1S/C17H15ClFN3O/c1-2-6-13(23)20-17-12-9-11(10-7-4-3-5-8-10)14(18)15(19)16(12)21-22-17/h3-5,7-9H,2,6H2,1H3,(H2,20,21,22,23)
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n/an/a 250n/an/an/an/an/an/a



Sanofi-aventis

Curated by ChEMBL


Assay Description
Inhibition of Tau phosphorylation in rat cerebral cortex after 120 mins by chemiluminescence assay


Citation and Details
More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM50384538
PNG
(CHEMBL2036419 | CHEMBL2036420)
Show SMILES CN(C)c1ccc(cc1)\N=N\c1nc2ccc(OCCOCCOCCF)cc2s1
Show InChI InChI=1S/C21H25FN4O3S/c1-26(2)17-5-3-16(4-6-17)24-25-21-23-19-8-7-18(15-20(19)30-21)29-14-13-28-12-11-27-10-9-22/h3-8,15H,9-14H2,1-2H3/b25-24+
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n/an/a 256n/an/an/an/an/an/a


TBA

Assay Description
Displacement of Thioflavin S from recombinant human tau expressed in Escherichia coli after 30 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM50055954
PNG
(CHEMBL3330751)
Show SMILES COc1ccc(cc1)-c1cc2n(c3cc(sc3c2s1)-c1ccc(C=O)s1)C(C)(C)C
Show InChI InChI=1S/C24H21NO2S3/c1-24(2,3)25-17-11-20(14-5-7-15(27-4)8-6-14)29-22(17)23-18(25)12-21(30-23)19-10-9-16(13-26)28-19/h5-13H,1-4H3
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n/an/a<290n/an/an/an/an/an/a



Tokyo Institute of Technology

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human brain tau 3R MBD aggregation after 16 hrs by thioflavin T fluorescence method


Citation and Details
More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM50055956
PNG
(CHEMBL3330753)
Show SMILES COc1ccc(cc1)-c1cc2n(c3cc(sc3c2s1)-c1ccc(\C=C(/C#N)C(N)=O)s1)C(C)(C)C
Show InChI InChI=1S/C27H23N3O2S3/c1-27(2,3)30-19-12-22(15-5-7-17(32-4)8-6-15)34-24(19)25-20(30)13-23(35-25)21-10-9-18(33-21)11-16(14-28)26(29)31/h5-13H,1-4H3,(H2,29,31)/b16-11+
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n/an/a 300n/an/an/an/an/an/a



Tokyo Institute of Technology

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human brain tau 3R MBD aggregation after 16 hrs by thioflavin T fluorescence method


Citation and Details
More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM32299
PNG
(2-[(2Z)-2-[(2E)-2-[[3-(2-hydroxyethyl)-5-methoxy-1...)
Show SMILES CC\C(=C/c1sc2ccc(OC)cc2[n+]1CCO)\C=C1/Sc2ccc(OC)cc2N1CCO
Show InChI InChI=1S/C25H29N2O4S2/c1-4-17(13-24-26(9-11-28)20-15-18(30-2)5-7-22(20)32-24)14-25-27(10-12-29)21-16-19(31-3)6-8-23(21)33-25/h5-8,13-16,28-29H,4,9-12H2,1-3H3/q+1
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n/an/a 380n/an/an/an/an/an/a



Humboldt-Universit£t zu Berlin

Curated by ChEMBL


Assay Description
Inhibition of tau protein aggregation (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Rattus norvegicus)
BDBM50313661
PNG
(CHEMBL1095040 | N-(6-chloro-5-phenyl-1H-indazol-3-...)
Show SMILES CCCC(=O)Nc1n[nH]c2cc(Cl)c(cc12)-c1ccccc1
Show InChI InChI=1S/C17H16ClN3O/c1-2-6-16(22)19-17-13-9-12(11-7-4-3-5-8-11)14(18)10-15(13)20-21-17/h3-5,7-10H,2,6H2,1H3,(H2,19,20,21,22)
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n/an/a 400n/an/an/an/an/an/a



Sanofi-aventis

Curated by ChEMBL


Assay Description
Inhibition of Tau phosphorylation in rat cerebral cortex after 120 mins by chemiluminescence assay


Citation and Details
More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM223577
PNG
(US9321752, 19-4)
Show SMILES Cn1cccc1\C=C\c1cc(\C=C\c2ccc(OCc3ccccn3)cc2F)n[nH]1
Show InChI InChI=1S/C24H21FN4O/c1-29-14-4-6-22(29)11-10-20-15-19(27-28-20)9-7-18-8-12-23(16-24(18)25)30-17-21-5-2-3-13-26-21/h2-16H,17H2,1H3,(H,27,28)/b9-7+,11-10+
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n/an/a 510n/an/an/an/an/an/a



GREEN TECH CO., LTD.

US Patent


Assay Description
Recombinant three-repeat microtubule-binding domain (3R-MBD) of tau protein was expressed in E. coli and was purified and used for the experiment. Th...


US Patent US9321752 (2016)

More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM223578
PNG
(US9321752, 20-3)
Show SMILES Cn1cccc1\C=C\c1cc(\C=C\c2ccc(OCc3ccccn3)cc2)n[nH]1
Show InChI InChI=1S/C24H22N4O/c1-28-16-4-6-23(28)12-11-21-17-20(26-27-21)10-7-19-8-13-24(14-9-19)29-18-22-5-2-3-15-25-22/h2-17H,18H2,1H3,(H,26,27)/b10-7+,12-11+
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n/an/a 550n/an/an/an/an/an/a



GREEN TECH CO., LTD.

US Patent


Assay Description
Recombinant three-repeat microtubule-binding domain (3R-MBD) of tau protein was expressed in E. coli and was purified and used for the experiment. Th...


US Patent US9321752 (2016)

More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM223580
PNG
(US9321752, 23-2)
Show SMILES COc1cc(OCc2ccccn2)ccc1\C=C\c1cc(\C=C\c2ccc(C)n2C)[nH]n1
Show InChI InChI=1S/C26H26N4O2/c1-19-7-12-24(30(19)2)13-11-22-16-21(28-29-22)10-8-20-9-14-25(17-26(20)31-3)32-18-23-6-4-5-15-27-23/h4-17H,18H2,1-3H3,(H,28,29)/b10-8+,13-11+
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n/an/a 590n/an/an/an/an/an/a



GREEN TECH CO., LTD.

US Patent


Assay Description
Recombinant three-repeat microtubule-binding domain (3R-MBD) of tau protein was expressed in E. coli and was purified and used for the experiment. Th...


US Patent US9321752 (2016)

More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM223575
PNG
(US9321752, 16-2)
Show SMILES Cn1ccc2ccc(\C=C\c3cc(\C=C\c4ccc(OCc5ccccn5)cc4F)n[nH]3)cc12
Show InChI InChI=1S/C28H23FN4O/c1-33-15-13-22-7-5-20(16-28(22)33)6-10-23-17-24(32-31-23)11-8-21-9-12-26(18-27(21)29)34-19-25-4-2-3-14-30-25/h2-18H,19H2,1H3,(H,31,32)/b10-6+,11-8+
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n/an/a 600n/an/an/an/an/an/a



GREEN TECH CO., LTD.

US Patent


Assay Description
Recombinant three-repeat microtubule-binding domain (3R-MBD) of tau protein was expressed in E. coli and was purified and used for the experiment. Th...


US Patent US9321752 (2016)

More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM223582
PNG
(US9321752, 32-5)
Show SMILES Cc1cc(OCc2ccccn2)ccc1\C=C\c1cc(\C=C\c2cccn2C)[nH]n1
Show InChI InChI=1S/C25H24N4O/c1-19-16-25(30-18-23-6-3-4-14-26-23)13-9-20(19)8-10-21-17-22(28-27-21)11-12-24-7-5-15-29(24)2/h3-17H,18H2,1-2H3,(H,27,28)/b10-8+,12-11+
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n/an/a 640n/an/an/an/an/an/a



GREEN TECH CO., LTD.

US Patent


Assay Description
Recombinant three-repeat microtubule-binding domain (3R-MBD) of tau protein was expressed in E. coli and was purified and used for the experiment. Th...


US Patent US9321752 (2016)

More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM223576
PNG
(US9321752, 17-2)
Show SMILES Cn1ccc2ccc(\C=C\c3cc(\C=C\c4ccc(OCc5ccccn5)cc4)n[nH]3)cc12
Show InChI InChI=1S/C28H24N4O/c1-32-17-15-23-10-5-22(18-28(23)32)7-12-25-19-24(30-31-25)11-6-21-8-13-27(14-9-21)33-20-26-4-2-3-16-29-26/h2-19H,20H2,1H3,(H,30,31)/b11-6+,12-7+
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n/an/a 650n/an/an/an/an/an/a



GREEN TECH CO., LTD.

US Patent


Assay Description
Recombinant three-repeat microtubule-binding domain (3R-MBD) of tau protein was expressed in E. coli and was purified and used for the experiment. Th...


US Patent US9321752 (2016)

More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM223579
PNG
(US9321752, 22-2)
Show SMILES COc1cc(OCc2ccccn2)ccc1\C=C\c1cc(\C=C\c2cccn2C)[nH]n1
Show InChI InChI=1S/C25H24N4O2/c1-29-15-5-7-23(29)12-11-21-16-20(27-28-21)10-8-19-9-13-24(17-25(19)30-2)31-18-22-6-3-4-14-26-22/h3-17H,18H2,1-2H3,(H,27,28)/b10-8+,12-11+
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n/an/a 660n/an/an/an/an/an/a



GREEN TECH CO., LTD.

US Patent


Assay Description
Recombinant three-repeat microtubule-binding domain (3R-MBD) of tau protein was expressed in E. coli and was purified and used for the experiment. Th...


US Patent US9321752 (2016)

More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM223583
PNG
(US9321752, 42-2)
Show SMILES COc1cc(OCc2ccccn2)ccc1\C=C\c1cc(\C=C\c2ccnn2C)[nH]n1
Show InChI InChI=1S/C24H23N5O2/c1-29-22(12-14-26-29)10-9-20-15-19(27-28-20)8-6-18-7-11-23(16-24(18)30-2)31-17-21-5-3-4-13-25-21/h3-16H,17H2,1-2H3,(H,27,28)/b8-6+,10-9+
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n/an/a 830n/an/an/an/an/an/a



GREEN TECH CO., LTD.

US Patent


Assay Description
Recombinant three-repeat microtubule-binding domain (3R-MBD) of tau protein was expressed in E. coli and was purified and used for the experiment. Th...


US Patent US9321752 (2016)

More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM223581
PNG
(US9321752, 25-2)
Show SMILES COc1cc(OCc2ccccn2)ccc1\C=C\c1cc(\C=C\c2cccc(C)n2)[nH]n1
Show InChI InChI=1S/C26H24N4O2/c1-19-6-5-8-21(28-19)12-13-23-16-22(29-30-23)11-9-20-10-14-25(17-26(20)31-2)32-18-24-7-3-4-15-27-24/h3-17H,18H2,1-2H3,(H,29,30)/b11-9+,13-12+
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n/an/a 840n/an/an/an/an/an/a



GREEN TECH CO., LTD.

US Patent


Assay Description
Recombinant three-repeat microtubule-binding domain (3R-MBD) of tau protein was expressed in E. coli and was purified and used for the experiment. Th...


US Patent US9321752 (2016)

More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM223584
PNG
(US9321752, 53-2)
Show SMILES C(CN1CCOCC1)Oc1cccc(\C=C\c2cc(\C=C\c3ccc4cc[nH]c4c3)[nH]n2)c1
Show InChI InChI=1S/C27H28N4O2/c1-2-21(18-26(3-1)33-17-14-31-12-15-32-16-13-31)5-8-24-20-25(30-29-24)9-6-22-4-7-23-10-11-28-27(23)19-22/h1-11,18-20,28H,12-17H2,(H,29,30)/b8-5+,9-6+
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n/an/a 840n/an/an/an/an/an/a



GREEN TECH CO., LTD.

US Patent


Assay Description
Recombinant three-repeat microtubule-binding domain (3R-MBD) of tau protein was expressed in E. coli and was purified and used for the experiment. Th...


US Patent US9321752 (2016)

More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM50434368
PNG
(CHEMBL2386876)
Show SMILES Cc1ccc(cc1)C(=O)N\N=C\c1ccc(O)c(O)c1O
Show InChI InChI=1S/C15H14N2O4/c1-9-2-4-10(5-3-9)15(21)17-16-8-11-6-7-12(18)14(20)13(11)19/h2-8,18-20H,1H3,(H,17,21)/b16-8+
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n/an/a 970n/an/an/an/an/an/a



Humboldt-Universit£t zu Berlin

Curated by ChEMBL


Assay Description
Inhibition of tau protein aggregation (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM15236
PNG
(3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chr...)
Show SMILES Oc1cc(O)c2c(c1)oc(-c1cc(O)c(O)c(O)c1)c(O)c2=O
Show InChI InChI=1S/C15H10O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,16-20,22H
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n/an/a 1.20E+3n/an/an/an/an/an/a



Humboldt-Universit£t zu Berlin

Curated by ChEMBL


Assay Description
Inhibition of human recombinant brain tau protein (412 amino acid residues) filament assembly expressed in Escherichia coli BL21(DE3) by electron mic...


Citation and Details
More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM50398200
PNG
(CHEMBL2181538)
Show SMILES CN(C)c1ccc(\C=C\c2cc(c(\C=C\c3ccc(cc3)N(C)C)nn2)-c2ccccc2F)cc1
Show InChI InChI=1S/C30H29FN4/c1-34(2)25-16-10-22(11-17-25)9-15-24-21-28(27-7-5-6-8-29(27)31)30(33-32-24)20-14-23-12-18-26(19-13-23)35(3)4/h5-21H,1-4H3/b15-9+,20-14+
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n/an/a 1.25E+3n/an/an/an/an/an/a



Technische Universit£t Darmstadt

Curated by ChEMBL


Assay Description
Displacement of thiazene red from tau aggregate


Citation and Details
More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM50398201
PNG
(CHEMBL2181537)
Show SMILES COc1ccc(cc1)-c1cc(\C=C\c2ccc(cc2)N(C)C)nnc1\C=C\c1ccc(cc1)N(C)C
Show InChI InChI=1S/C31H32N4O/c1-34(2)27-15-7-23(8-16-27)6-14-26-22-30(25-12-19-29(36-5)20-13-25)31(33-32-26)21-11-24-9-17-28(18-10-24)35(3)4/h6-22H,1-5H3/b14-6+,21-11+
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n/an/a 1.59E+3n/an/an/an/an/an/a



Technische Universit£t Darmstadt

Curated by ChEMBL


Assay Description
Displacement of thiazene red from tau aggregate


Citation and Details
More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM50055957
PNG
(CHEMBL3330754)
Show SMILES O=Cc1ccc(s1)-c1ccc(s1)-c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C17H11NOS2/c19-10-13-2-4-16(20-13)17-6-5-15(21-17)12-1-3-14-11(9-12)7-8-18-14/h1-10,18H
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n/an/a 1.60E+3n/an/an/an/an/an/a



Tokyo Institute of Technology

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human brain tau 3R MBD aggregation after 16 hrs by thioflavin T fluorescence method


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Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM50185987
PNG
(2-(1-(6-((2-fluoroethyl)(methyl)amino)naphthalen-2...)
Show SMILES CN(CCF)c1ccc2cc(ccc2c1)C(C)=C(C#N)C#N
Show InChI InChI=1S/C18H16FN3/c1-13(17(11-20)12-21)14-3-4-16-10-18(22(2)8-7-19)6-5-15(16)9-14/h3-6,9-10H,7-8H2,1-2H3
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PubMed
n/an/a 1.64E+3n/an/an/an/an/an/a



Technische Universit£t Darmstadt

Curated by ChEMBL


Assay Description
Displacement of thiazine red R from human Tau aggregate expressed in Escherichia coli after 30 mins by fluorimetric analysis


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More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM50055941
PNG
(CHEMBL3330737)
Show SMILES OC(=O)C(=C\c1ccc(s1)-c1ccc(s1)-c1ccc(cc1)N(c1ccccc1)c1ccccc1)\C#N
Show InChI InChI=1S/C30H20N2O2S2/c31-20-22(30(33)34)19-26-15-16-28(35-26)29-18-17-27(36-29)21-11-13-25(14-12-21)32(23-7-3-1-4-8-23)24-9-5-2-6-10-24/h1-19H,(H,33,34)/b22-19+
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n/an/a 1.70E+3n/an/an/an/an/an/a



Tokyo Institute of Technology

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human brain tau 3R MBD aggregation after 16 hrs by thioflavin T fluorescence method


Citation and Details
More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM50070942
PNG
((-)-Epigallocatechin gallate | (-)-Epigallocatechi...)
Show SMILES Oc1cc(O)c2C[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@H](Oc2c1)c1cc(O)c(O)c(O)c1
Show InChI InChI=1S/C22H18O11/c23-10-5-12(24)11-7-18(33-22(31)9-3-15(27)20(30)16(28)4-9)21(32-17(11)6-10)8-1-13(25)19(29)14(26)2-8/h1-6,18,21,23-30H,7H2/t18-,21-/m1/s1
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n/an/a 1.80E+3n/an/an/an/an/an/a



Humboldt-Universit£t zu Berlin

Curated by ChEMBL


Assay Description
Inhibition of human recombinant brain tau protein (412 amino acid residues) filament assembly expressed in Escherichia coli BL21(DE3) by electron mic...


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More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM50434369
PNG
(METHYLENE BLUE CHLORIDE HYDRATE | Methylene Blue |...)
Show SMILES CN(C)c1ccc2nc3ccc(cc3sc2c1)=[N+](C)C
Show InChI InChI=1S/C16H18N3S/c1-18(2)11-5-7-13-15(9-11)20-16-10-12(19(3)4)6-8-14(16)17-13/h5-10H,1-4H3/q+1
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n/an/a 1.90E+3n/an/an/an/an/an/a



Humboldt-Universit£t zu Berlin

Curated by ChEMBL


Assay Description
Inhibition of human recombinant brain tau protein (412 amino acid residues) filament assembly expressed in Escherichia coli BL21(DE3) by electron mic...


Citation and Details
More data for this
Ligand-Target Pair
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