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Compile Data Set for Download or QSAR

Found 1816 hits Enz. Inhib. hit(s) with Target = 'Mitogen-Activated Protein Kinase 10 (JNK3)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50059652
PNG
(CHEMBL3220502)
Show SMILES NC(=O)c1ccccc1Nc1nc(Nc2ccc(cc2)N2CCCC2=O)ncc1Cl
Show InChI InChI=1S/C21H19ClN6O2/c22-16-12-24-21(27-20(16)26-17-5-2-1-4-15(17)19(23)30)25-13-7-9-14(10-8-13)28-11-3-6-18(28)29/h1-2,4-5,7-10,12H,3,6,11H2,(H2,23,30)(H2,24,25,26,27)
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n/an/a 0.160n/an/an/an/an/an/a



Eberhard Karls Universit£t T£bingen

Curated by ChEMBL


Assay Description
Inhibition of JNK3 (unknown origin) by time-resolved fluorescence assay


J Med Chem 58: 72-95 (2015)


Article DOI: 10.1021/jm501212r
BindingDB Entry DOI: 10.7270/Q2JH3NVZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50059649
PNG
(CHEMBL3220493)
Show SMILES NC(=O)c1ccccc1Nc1nc(Nc2ccc(cc2)N2CCOCC2)ncc1Cl
Show InChI InChI=1S/C21H21ClN6O2/c22-17-13-24-21(27-20(17)26-18-4-2-1-3-16(18)19(23)29)25-14-5-7-15(8-6-14)28-9-11-30-12-10-28/h1-8,13H,9-12H2,(H2,23,29)(H2,24,25,26,27)
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n/an/a 0.300n/an/an/an/an/an/a



Eberhard Karls Universit£t T£bingen

Curated by ChEMBL


Assay Description
Inhibition of JNK3 (unknown origin) by time-resolved fluorescence assay


J Med Chem 58: 72-95 (2015)


Article DOI: 10.1021/jm501212r
BindingDB Entry DOI: 10.7270/Q2JH3NVZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50234890
PNG
(CHEMBL4077018)
Show SMILES CSc1nc(c(-c2ccnc(Nc3ccc(NC(=O)c4cccc(NC(=O)C=C)c4)cc3)c2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C32H27FN6O2S/c1-4-28(40)36-26-7-5-6-22(18-26)31(41)37-25-14-12-24(13-15-25)35-27-19-21(16-17-34-27)30-29(38-32(42-3)39(30)2)20-8-10-23(33)11-9-20/h4-19H,1H2,2-3H3,(H,34,35)(H,36,40)(H,37,41)
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n/an/a 0.300n/an/an/an/an/an/a



Eberhard Karls Universit£t T£bingen

Curated by ChEMBL


Assay Description
Inhibition of recombinant 6x-His-tagged JNK3 (39 to 402 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as reduction in A...


J Med Chem 60: 594-607 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01180
BindingDB Entry DOI: 10.7270/Q2891854
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM86634
PNG
(JNK-IN-9)
Show SMILES CN(C)C\C=C\C(=O)Nc1ccc(C)c(c1)C(=O)Nc1ccc(Nc2nccc(n2)-c2cccnc2)cc1
Show InChI InChI=1S/C29H29N7O2/c1-20-8-9-24(32-27(37)7-5-17-36(2)3)18-25(20)28(38)33-22-10-12-23(13-11-22)34-29-31-16-14-26(35-29)21-6-4-15-30-19-21/h4-16,18-19H,17H2,1-3H3,(H,32,37)(H,33,38)(H,31,34,35)/b7-5+
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n/an/a 0.5n/an/an/an/an/an/a



Harvard Medical School



Assay Description
The binding results were confirmed by measuring IC50 for the inhibition of JNK kinase activity by using Z'-LYTE assay format.


Chem Biol 19: 140-54 (2012)


Article DOI: 10.1016/j.chembiol.2011.11.010
BindingDB Entry DOI: 10.7270/Q2K35S8X
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM86635
PNG
(JNK-IN-10)
Show SMILES CN(C)C\C=C\C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(Nc2nccc(n2)-c2cccnc2)cc1
Show InChI InChI=1S/C29H29N7O2/c1-20-8-9-21(18-26(20)34-27(37)7-5-17-36(2)3)28(38)32-23-10-12-24(13-11-23)33-29-31-16-14-25(35-29)22-6-4-15-30-19-22/h4-16,18-19H,17H2,1-3H3,(H,32,38)(H,34,37)(H,31,33,35)/b7-5+
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n/an/a 0.5n/an/an/an/an/an/a



Harvard Medical School



Assay Description
The binding results were confirmed by measuring IC50 for the inhibition of JNK kinase activity by using Z'-LYTE assay format.


Chem Biol 19: 140-54 (2012)


Article DOI: 10.1016/j.chembiol.2011.11.010
BindingDB Entry DOI: 10.7270/Q2K35S8X
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM86636
PNG
(JNK-IN-11)
Show SMILES CN(C)C\C=C\C(=O)Nc1cccc(c1)C(=O)Nc1ccc(Nc2nccc(n2)-c2c(nn3ccccc23)-c2ccccc2)cc1
Show InChI InChI=1S/C36H32N8O2/c1-43(2)22-9-15-32(45)38-29-13-8-12-26(24-29)35(46)39-27-16-18-28(19-17-27)40-36-37-21-20-30(41-36)33-31-14-6-7-23-44(31)42-34(33)25-10-4-3-5-11-25/h3-21,23-24H,22H2,1-2H3,(H,38,45)(H,39,46)(H,37,40,41)/b15-9+
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n/an/a 0.5n/an/an/an/an/an/a



Harvard Medical School



Assay Description
The binding results were confirmed by measuring IC50 for the inhibition of JNK kinase activity by using Z'-LYTE assay format.


Chem Biol 19: 140-54 (2012)


Article DOI: 10.1016/j.chembiol.2011.11.010
BindingDB Entry DOI: 10.7270/Q2K35S8X
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM86636
PNG
(JNK-IN-11)
Show SMILES CN(C)C\C=C\C(=O)Nc1cccc(c1)C(=O)Nc1ccc(Nc2nccc(n2)-c2c(nn3ccccc23)-c2ccccc2)cc1
Show InChI InChI=1S/C36H32N8O2/c1-43(2)22-9-15-32(45)38-29-13-8-12-26(24-29)35(46)39-27-16-18-28(19-17-27)40-36-37-21-20-30(41-36)33-31-14-6-7-23-44(31)42-34(33)25-10-4-3-5-11-25/h3-21,23-24H,22H2,1-2H3,(H,38,45)(H,39,46)(H,37,40,41)/b15-9+
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Eberhard Karls Universit£t T£bingen

Curated by ChEMBL


Assay Description
Inhibition of JNK3 (unknown origin) after 1 hr incubation


J Med Chem 58: 72-95 (2015)


Article DOI: 10.1021/jm501212r
BindingDB Entry DOI: 10.7270/Q2JH3NVZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50234889
PNG
(CHEMBL4062023)
Show SMILES CSc1nc(c([nH]1)-c1ccnc(Nc2ccc(NC(=O)c3cccc(NC(=O)C=C)c3)cc2)c1)-c1ccc(F)cc1
Show InChI InChI=1S/C31H25FN6O2S/c1-3-27(39)35-25-6-4-5-21(17-25)30(40)36-24-13-11-23(12-14-24)34-26-18-20(15-16-33-26)29-28(37-31(38-29)41-2)19-7-9-22(32)10-8-19/h3-18H,1H2,2H3,(H,33,34)(H,35,39)(H,36,40)(H,37,38)
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n/an/a 0.600n/an/an/an/an/an/a



Eberhard Karls Universit£t T£bingen

Curated by ChEMBL


Assay Description
Inhibition of recombinant 6x-His-tagged JNK3 (39 to 402 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as reduction in A...


J Med Chem 60: 594-607 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01180
BindingDB Entry DOI: 10.7270/Q2891854
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM86632
PNG
(JNK-IN-7)
Show SMILES CN(C)C\C=C\C(=O)Nc1cccc(c1)C(=O)Nc1ccc(Nc2nccc(n2)-c2cccnc2)cc1
Show InChI InChI=1S/C28H27N7O2/c1-35(2)17-5-9-26(36)31-24-8-3-6-20(18-24)27(37)32-22-10-12-23(13-11-22)33-28-30-16-14-25(34-28)21-7-4-15-29-19-21/h3-16,18-19H,17H2,1-2H3,(H,31,36)(H,32,37)(H,30,33,34)/b9-5+
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n/an/a 0.700n/an/an/an/an/an/a



Eberhard Karls Universit£t T£bingen

Curated by ChEMBL


Assay Description
Inhibition of JNK3 (unknown origin) after 1 hr incubation


J Med Chem 58: 72-95 (2015)


Article DOI: 10.1021/jm501212r
BindingDB Entry DOI: 10.7270/Q2JH3NVZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM86632
PNG
(JNK-IN-7)
Show SMILES CN(C)C\C=C\C(=O)Nc1cccc(c1)C(=O)Nc1ccc(Nc2nccc(n2)-c2cccnc2)cc1
Show InChI InChI=1S/C28H27N7O2/c1-35(2)17-5-9-26(36)31-24-8-3-6-20(18-24)27(37)32-22-10-12-23(13-11-22)33-28-30-16-14-25(34-28)21-7-4-15-29-19-21/h3-16,18-19H,17H2,1-2H3,(H,31,36)(H,32,37)(H,30,33,34)/b9-5+
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n/an/a 0.75n/an/an/an/an/an/a



Harvard Medical School



Assay Description
The binding results were confirmed by measuring IC50 for the inhibition of JNK kinase activity by using Z'-LYTE assay format.


Chem Biol 19: 140-54 (2012)


Article DOI: 10.1016/j.chembiol.2011.11.010
BindingDB Entry DOI: 10.7270/Q2K35S8X
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50059650
PNG
(CHEMBL3220495)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2C(N)=O)n1)N1CCOCC1
Show InChI InChI=1S/C22H23ClN6O3/c1-31-19-12-14(29-8-10-32-11-9-29)6-7-18(19)27-22-25-13-16(23)21(28-22)26-17-5-3-2-4-15(17)20(24)30/h2-7,12-13H,8-11H2,1H3,(H2,24,30)(H2,25,26,27,28)
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n/an/a 0.800n/an/an/an/an/an/a



Eberhard Karls Universit£t T£bingen

Curated by ChEMBL


Assay Description
Inhibition of JNK3 (unknown origin) by time-resolved fluorescence assay


J Med Chem 58: 72-95 (2015)


Article DOI: 10.1021/jm501212r
BindingDB Entry DOI: 10.7270/Q2JH3NVZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM86630
PNG
(JNK-IN-5)
Show SMILES C=CC(=O)Nc1cccc(c1)C(=O)Nc1ccc(Nc2nccc(n2)-c2cccnc2)cc1
Show InChI InChI=1S/C25H20N6O2/c1-2-23(32)28-21-7-3-5-17(15-21)24(33)29-19-8-10-20(11-9-19)30-25-27-14-12-22(31-25)18-6-4-13-26-16-18/h2-16H,1H2,(H,28,32)(H,29,33)(H,27,30,31)
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n/an/a 0.960n/an/an/an/an/an/a



Harvard Medical School



Assay Description
The binding results were confirmed by measuring IC50 for the inhibition of JNK kinase activity by using Z'-LYTE assay format.


Chem Biol 19: 140-54 (2012)


Article DOI: 10.1016/j.chembiol.2011.11.010
BindingDB Entry DOI: 10.7270/Q2K35S8X
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM86633
PNG
(JNK-IN-8)
Show SMILES CN(C)C\C=C\C(=O)Nc1cccc(c1)C(=O)Nc1ccc(Nc2nccc(n2)-c2cccnc2)c(C)c1
Show InChI InChI=1S/C29H29N7O2/c1-20-17-24(11-12-25(20)34-29-31-15-13-26(35-29)22-8-5-14-30-19-22)33-28(38)21-7-4-9-23(18-21)32-27(37)10-6-16-36(2)3/h4-15,17-19H,16H2,1-3H3,(H,32,37)(H,33,38)(H,31,34,35)/b10-6+
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n/an/a 0.980n/an/an/an/an/an/a



Harvard Medical School



Assay Description
The binding results were confirmed by measuring IC50 for the inhibition of JNK kinase activity by using Z'-LYTE assay format.


Chem Biol 19: 140-54 (2012)


Article DOI: 10.1016/j.chembiol.2011.11.010
BindingDB Entry DOI: 10.7270/Q2K35S8X
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM86633
PNG
(JNK-IN-8)
Show SMILES CN(C)C\C=C\C(=O)Nc1cccc(c1)C(=O)Nc1ccc(Nc2nccc(n2)-c2cccnc2)c(C)c1
Show InChI InChI=1S/C29H29N7O2/c1-20-17-24(11-12-25(20)34-29-31-15-13-26(35-29)22-8-5-14-30-19-22)33-28(38)21-7-4-9-23(18-21)32-27(37)10-6-16-36(2)3/h4-15,17-19H,16H2,1-3H3,(H,32,37)(H,33,38)(H,31,34,35)/b10-6+
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n/an/a 0.980n/an/an/an/an/an/a



Covalution Pharma BV

Curated by ChEMBL


Assay Description
Inhibition of JNK3


J Med Chem 55: 6243-62 (2012)


Article DOI: 10.1021/jm3003203
BindingDB Entry DOI: 10.7270/Q2X92CGP
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50032821
PNG
(CHEMBL3355178)
Show SMILES Clc1ccccc1NC(=O)Nc1cnn(c1)-c1cccc(c1)C(=O)Nc1cnn(c1)C1CCNC1
Show InChI InChI=1/C24H23ClN8O2/c25-21-6-1-2-7-22(21)31-24(35)30-18-12-27-32(15-18)19-5-3-4-16(10-19)23(34)29-17-11-28-33(14-17)20-8-9-26-13-20/h1-7,10-12,14-15,20,26H,8-9,13H2,(H,29,34)(H2,30,31,35)
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n/an/a<1n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of JNK3alpha1 (unknown origin) after 1 hr by homogeneous time-resolved fluorescence assay


J Med Chem 57: 10013-30 (2014)


Article DOI: 10.1021/jm501256y
BindingDB Entry DOI: 10.7270/Q25140TS
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM86633
PNG
(JNK-IN-8)
Show SMILES CN(C)C\C=C\C(=O)Nc1cccc(c1)C(=O)Nc1ccc(Nc2nccc(n2)-c2cccnc2)c(C)c1
Show InChI InChI=1S/C29H29N7O2/c1-20-17-24(11-12-25(20)34-29-31-15-13-26(35-29)22-8-5-14-30-19-22)33-28(38)21-7-4-9-23(18-21)32-27(37)10-6-16-36(2)3/h4-15,17-19H,16H2,1-3H3,(H,32,37)(H,33,38)(H,31,34,35)/b10-6+
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n/an/a 1n/an/an/an/an/an/a



Eberhard Karls Universit£t T£bingen

Curated by ChEMBL


Assay Description
Inhibition of JNK3 (unknown origin) after 1 hr incubation


J Med Chem 58: 72-95 (2015)


Article DOI: 10.1021/jm501212r
BindingDB Entry DOI: 10.7270/Q2JH3NVZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50495031
PNG
(CHEMBL3099975)
Show SMILES Oc1onc(c1-c1ccc(F)cc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)c1
Show InChI InChI=1S/C24H21FN4O3/c25-18-3-1-16(2-4-18)22-23(28-32-24(22)30)17-9-10-26-21(15-17)27-19-5-7-20(8-6-19)29-11-13-31-14-12-29/h1-10,15,30H,11-14H2,(H,26,27)
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The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of JNK3 (39 to 402 amino acids) (unknown origin) expressed in Escherichia coli BL21(DE3) using biotinylated ATF2 as substrate after 15 min...


Bioorg Med Chem Lett 24: 161-4 (2014)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM86633
PNG
(JNK-IN-8)
Show SMILES CN(C)C\C=C\C(=O)Nc1cccc(c1)C(=O)Nc1ccc(Nc2nccc(n2)-c2cccnc2)c(C)c1
Show InChI InChI=1S/C29H29N7O2/c1-20-17-24(11-12-25(20)34-29-31-15-13-26(35-29)22-8-5-14-30-19-22)33-28(38)21-7-4-9-23(18-21)32-27(37)10-6-16-36(2)3/h4-15,17-19H,16H2,1-3H3,(H,32,37)(H,33,38)(H,31,34,35)/b10-6+
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PubMed
n/an/a 1n/an/an/an/an/an/a



University of Pittsburgh

Curated by ChEMBL


Assay Description
Inhibition of JNK3 (unknown origin) after 1 hr by FRET-based assay


J Med Chem 60: 839-885 (2017)


Article DOI: 10.1021/acs.jmedchem.6b00788
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50172920
PNG
(3-(6-(2-chlorophenylamino)-1H-indazol-3-yl)-N-(pip...)
Show SMILES Clc1ccccc1Nc1ccc2c(n[nH]c2c1)-c1cccc(c1)C(=O)NC1CCNCC1
Show InChI InChI=1S/C25H24ClN5O/c26-21-6-1-2-7-22(21)28-19-8-9-20-23(15-19)30-31-24(20)16-4-3-5-17(14-16)25(32)29-18-10-12-27-13-11-18/h1-9,14-15,18,27-28H,10-13H2,(H,29,32)(H,30,31)
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n/an/a 1.26n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of JNK3 by high throughput screening


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
BindingDB Entry DOI: 10.7270/Q2Z320WR
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50172920
PNG
(3-(6-(2-chlorophenylamino)-1H-indazol-3-yl)-N-(pip...)
Show SMILES Clc1ccccc1Nc1ccc2c(n[nH]c2c1)-c1cccc(c1)C(=O)NC1CCNCC1
Show InChI InChI=1S/C25H24ClN5O/c26-21-6-1-2-7-22(21)28-19-8-9-20-23(15-19)30-31-24(20)16-4-3-5-17(14-16)25(32)29-18-10-12-27-13-11-18/h1-9,14-15,18,27-28H,10-13H2,(H,29,32)(H,30,31)
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n/an/a 1.40n/an/an/an/an/an/a



AstraZeneca R&D Södertälje

Curated by ChEMBL


Assay Description
Inhibitory concentration against c-Jun N-terminal kinase 3


Bioorg Med Chem Lett 15: 5095-9 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.083
BindingDB Entry DOI: 10.7270/Q2JW8DFC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM16015
PNG
(CHEMBL252967 | N-cyclopropyl-4-[4-(3,4-dichlorophe...)
Show SMILES CCCn1c(nc(c1-c1ccnc(NC2CC2)n1)-c1ccc(Cl)c(Cl)c1)C1CCN(C)CC1
Show InChI InChI=1S/C25H30Cl2N6/c1-3-12-33-23(21-8-11-28-25(30-21)29-18-5-6-18)22(17-4-7-19(26)20(27)15-17)31-24(33)16-9-13-32(2)14-10-16/h4,7-8,11,15-16,18H,3,5-6,9-10,12-14H2,1-2H3,(H,28,29,30)
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n/an/a 1.60n/an/an/an/an/an/a



Aureus Pharma

Curated by ChEMBL


Assay Description
Inhibition of JNK3


Bioorg Med Chem 15: 4256-64 (2007)


Article DOI: 10.1016/j.bmc.2007.03.062
BindingDB Entry DOI: 10.7270/Q2T43SSD
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM16016
PNG
(CHEMBL437747 | N-cyclohexyl-4-[4-(3,4-dichlorophen...)
Show SMILES CCCn1c(nc(c1-c1ccnc(NC2CCCCC2)n1)-c1ccc(Cl)c(Cl)c1)C1CCNCC1
Show InChI InChI=1S/C27H34Cl2N6/c1-2-16-35-25(23-12-15-31-27(33-23)32-20-6-4-3-5-7-20)24(19-8-9-21(28)22(29)17-19)34-26(35)18-10-13-30-14-11-18/h8-9,12,15,17-18,20,30H,2-7,10-11,13-14,16H2,1H3,(H,31,32,33)
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n/an/a 1.60n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM16016
PNG
(CHEMBL437747 | N-cyclohexyl-4-[4-(3,4-dichlorophen...)
Show SMILES CCCn1c(nc(c1-c1ccnc(NC2CCCCC2)n1)-c1ccc(Cl)c(Cl)c1)C1CCNCC1
Show InChI InChI=1S/C27H34Cl2N6/c1-2-16-35-25(23-12-15-31-27(33-23)32-20-6-4-3-5-7-20)24(19-8-9-21(28)22(29)17-19)34-26(35)18-10-13-30-14-11-18/h8-9,12,15,17-18,20,30H,2-7,10-11,13-14,16H2,1H3,(H,31,32,33)
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n/an/a 1.60n/an/an/an/a7.022



Merck Research Laboratories



Assay Description
HTRF relies on fluorescence resonance energy transfer (FRET) between the donor, a europium cryptate (EuK), and the acceptor, the light harvesting pro...


Chem Biol 10: 705-12 (2003)


Article DOI: 10.1016/S1074-5521(03)00159-5
BindingDB Entry DOI: 10.7270/Q2DJ5CWZ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50043768
PNG
(CHEMBL3355999)
Show SMILES N[C@H]1CC[C@@H](CC1)Nc1nccc(n1)-c1cccnc1Oc1ccc(Nc2nc3ccccc3[nH]2)c2ccccc12
Show InChI InChI=1/C32H30N8O/c33-20-11-13-21(14-12-20)36-31-35-19-17-26(37-31)24-8-5-18-34-30(24)41-29-16-15-25(22-6-1-2-7-23(22)29)38-32-39-27-9-3-4-10-28(27)40-32/h1-10,15-21H,11-14,33H2,(H,35,36,37)(H2,38,39,40)/t20-,21-
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n/an/a 1.90n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human wild type JNK3 using biotinylated ATF2 substrate assessed as phosphorylation at thr53 on ATF2 by fluorescent plate reader


ACS Med Chem Lett 6: 68-72 (2015)


Article DOI: 10.1021/ml500315b
BindingDB Entry DOI: 10.7270/Q2DF6STC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50211306
PNG
(4-(6-(2-chlorophenylamino)-1H-indazol-3-yl)-N-(2-(...)
Show SMILES CN(C)CCNC(=O)c1ccc(cc1)-c1n[nH]c2cc(Nc3ccccc3Cl)ccc12
Show InChI InChI=1S/C24H24ClN5O/c1-30(2)14-13-26-24(31)17-9-7-16(8-10-17)23-19-12-11-18(15-22(19)28-29-23)27-21-6-4-3-5-20(21)25/h3-12,15,27H,13-14H2,1-2H3,(H,26,31)(H,28,29)
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n/an/a 1.90n/an/an/an/an/an/a



AstraZeneca R&D Södertälje

Curated by ChEMBL


Assay Description
Inhibitory concentration against c-Jun N-terminal kinase 3


Bioorg Med Chem Lett 15: 5095-9 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.083
BindingDB Entry DOI: 10.7270/Q2JW8DFC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50211306
PNG
(4-(6-(2-chlorophenylamino)-1H-indazol-3-yl)-N-(2-(...)
Show SMILES CN(C)CCNC(=O)c1ccc(cc1)-c1n[nH]c2cc(Nc3ccccc3Cl)ccc12
Show InChI InChI=1S/C24H24ClN5O/c1-30(2)14-13-26-24(31)17-9-7-16(8-10-17)23-19-12-11-18(15-22(19)28-29-23)27-21-6-4-3-5-20(21)25/h3-12,15,27H,13-14H2,1-2H3,(H,26,31)(H,28,29)
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n/an/a 1.90n/an/an/an/an/an/a



Aureus Pharma

Curated by ChEMBL


Assay Description
Inhibition of JNK3


Bioorg Med Chem 15: 4256-64 (2007)


Article DOI: 10.1016/j.bmc.2007.03.062
BindingDB Entry DOI: 10.7270/Q2T43SSD
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50043704
PNG
(CHEMBL3356001)
Show SMILES Cc1cc(Nc2nc3ccccc3[nH]2)c2ccccc2c1Oc1ncccc1-c1ccnc(N[C@H]2CC[C@H](N)CC2)n1
Show InChI InChI=1/C33H32N8O/c1-20-19-29(41-33-39-27-10-4-5-11-28(27)40-33)23-7-2-3-8-24(23)30(20)42-31-25(9-6-17-35-31)26-16-18-36-32(38-26)37-22-14-12-21(34)13-15-22/h2-11,16-19,21-22H,12-15,34H2,1H3,(H,36,37,38)(H2,39,40,41)/t21-,22-
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n/an/a 1.90n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human wild type JNK3 using biotinylated ATF2 substrate assessed as phosphorylation at thr53 on ATF2 by fluorescent plate reader


ACS Med Chem Lett 6: 68-72 (2015)


Article DOI: 10.1021/ml500315b
BindingDB Entry DOI: 10.7270/Q2DF6STC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50234880
PNG
(CHEMBL4086457)
Show SMILES CSc1nc(c(-c2ccnc(Nc3ccc(NC(=O)c4cccc(NC(=O)C=C)c4C)cc3)c2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C33H29FN6O2S/c1-5-29(41)38-27-8-6-7-26(20(27)2)32(42)37-25-15-13-24(14-16-25)36-28-19-22(17-18-35-28)31-30(39-33(43-4)40(31)3)21-9-11-23(34)12-10-21/h5-19H,1H2,2-4H3,(H,35,36)(H,37,42)(H,38,41)
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n/an/a 2n/an/an/an/an/an/a



Eberhard Karls Universit£t T£bingen

Curated by ChEMBL


Assay Description
Inhibition of recombinant 6x-His-tagged JNK3 (39 to 402 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as reduction in A...


J Med Chem 60: 594-607 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01180
BindingDB Entry DOI: 10.7270/Q2891854
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50234883
PNG
(CHEMBL4069805)
Show SMILES CCC(=O)Nc1cccc(c1)C(=O)Nc1ccc(Nc2cc(ccn2)-c2[nH]c(SC)nc2-c2ccc(F)cc2)cc1
Show InChI InChI=1S/C31H27FN6O2S/c1-3-27(39)35-25-6-4-5-21(17-25)30(40)36-24-13-11-23(12-14-24)34-26-18-20(15-16-33-26)29-28(37-31(38-29)41-2)19-7-9-22(32)10-8-19/h4-18H,3H2,1-2H3,(H,33,34)(H,35,39)(H,36,40)(H,37,38)
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n/an/a 2n/an/an/an/an/an/a



Eberhard Karls Universit£t T£bingen

Curated by ChEMBL


Assay Description
Inhibition of recombinant 6x-His-tagged JNK3 (39 to 402 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as reduction in A...


J Med Chem 60: 594-607 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01180
BindingDB Entry DOI: 10.7270/Q2891854
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50234885
PNG
(CHEMBL4092555)
Show SMILES CSc1nc(c(-c2ccnc(Nc3ccc(NC(=O)c4cccc(NC(=O)C=C)c4)cc3C)c2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C33H29FN6O2S/c1-5-29(41)36-25-8-6-7-23(18-25)32(42)37-26-13-14-27(20(2)17-26)38-28-19-22(15-16-35-28)31-30(39-33(43-4)40(31)3)21-9-11-24(34)12-10-21/h5-19H,1H2,2-4H3,(H,35,38)(H,36,41)(H,37,42)
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Eberhard Karls Universit£t T£bingen

Curated by ChEMBL


Assay Description
Inhibition of recombinant 6x-His-tagged JNK3 (39 to 402 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as reduction in A...


J Med Chem 60: 594-607 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01180
BindingDB Entry DOI: 10.7270/Q2891854
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50234886
PNG
(CHEMBL4082278)
Show SMILES CSc1nc(C)c([nH]1)-c1ccnc(Nc2ccc(NC(=O)c3cccc(NC(=O)C=C)c3)cc2)c1
Show InChI InChI=1S/C26H24N6O2S/c1-4-23(33)30-21-7-5-6-18(14-21)25(34)31-20-10-8-19(9-11-20)29-22-15-17(12-13-27-22)24-16(2)28-26(32-24)35-3/h4-15H,1H2,2-3H3,(H,27,29)(H,28,32)(H,30,33)(H,31,34)
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Eberhard Karls Universit£t T£bingen

Curated by ChEMBL


Assay Description
Inhibition of recombinant 6x-His-tagged JNK3 (39 to 402 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as reduction in A...


J Med Chem 60: 594-607 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01180
BindingDB Entry DOI: 10.7270/Q2891854
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50352620
PNG
(CHEMBL1822151)
Show SMILES Brc1csc(NC(=O)Cn2c3ccc(cc3ccc2=O)C#N)c1-c1nnc[nH]1
Show InChI InChI=1S/C18H11BrN6O2S/c19-12-8-28-18(16(12)17-21-9-22-24-17)23-14(26)7-25-13-3-1-10(6-20)5-11(13)2-4-15(25)27/h1-5,8-9H,7H2,(H,23,26)(H,21,22,24)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 using ser73 of c-jun as substrate preincubated for 15 mins measured after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 5521-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.100
BindingDB Entry DOI: 10.7270/Q29Z959K
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM16016
PNG
(CHEMBL437747 | N-cyclohexyl-4-[4-(3,4-dichlorophen...)
Show SMILES CCCn1c(nc(c1-c1ccnc(NC2CCCCC2)n1)-c1ccc(Cl)c(Cl)c1)C1CCNCC1
Show InChI InChI=1S/C27H34Cl2N6/c1-2-16-35-25(23-12-15-31-27(33-23)32-20-6-4-3-5-7-20)24(19-8-9-21(28)22(29)17-19)34-26(35)18-10-13-30-14-11-18/h8-9,12,15,17-18,20,30H,2-7,10-11,13-14,16H2,1H3,(H,31,32,33)
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n/an/a 2n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of JNK3


Bioorg Med Chem Lett 17: 495-500 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.013
BindingDB Entry DOI: 10.7270/Q2JQ10NQ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50352621
PNG
(CHEMBL1822152)
Show SMILES Brc1csc(NC(=O)Cn2c3cc(ccc3ccc2=O)C#N)c1-c1nnc[nH]1
Show InChI InChI=1S/C18H11BrN6O2S/c19-12-8-28-18(16(12)17-21-9-22-24-17)23-14(26)7-25-13-5-10(6-20)1-2-11(13)3-4-15(25)27/h1-5,8-9H,7H2,(H,23,26)(H,21,22,24)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 using ser73 of c-jun as substrate preincubated for 15 mins measured after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 5521-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.100
BindingDB Entry DOI: 10.7270/Q29Z959K
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50173167
PNG
((S)-(2-(4-fluorophenyl)-3-(2-(propylamino)pyrimidi...)
Show SMILES CCCNc1nccc(n1)-c1c(nc2CC[C@@H](CO)n12)-c1ccc(F)cc1
Show InChI InChI=1S/C20H22FN5O/c1-2-10-22-20-23-11-9-16(24-20)19-18(13-3-5-14(21)6-4-13)25-17-8-7-15(12-27)26(17)19/h3-6,9,11,15,27H,2,7-8,10,12H2,1H3,(H,22,23,24)/t15-/m0/s1
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n/an/a 2.5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of JNK3


J Med Chem 53: 3005-12 (2010)


Article DOI: 10.1021/jm9003279
BindingDB Entry DOI: 10.7270/Q2KS6RP5
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50173167
PNG
((S)-(2-(4-fluorophenyl)-3-(2-(propylamino)pyrimidi...)
Show SMILES CCCNc1nccc(n1)-c1c(nc2CC[C@@H](CO)n12)-c1ccc(F)cc1
Show InChI InChI=1S/C20H22FN5O/c1-2-10-22-20-23-11-9-16(24-20)19-18(13-3-5-14(21)6-4-13)25-17-8-7-15(12-27)26(17)19/h3-6,9,11,15,27H,2,7-8,10,12H2,1H3,(H,22,23,24)/t15-/m0/s1
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n/an/a 2.5n/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Inhibitory activity against c-Jun N-terminal kinase 3 at a concentration of 1.0 uM


Bioorg Med Chem Lett 15: 4666-70 (2005)


Article DOI: 10.1016/j.bmcl.2005.07.076
BindingDB Entry DOI: 10.7270/Q28G8K8K
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50234879
PNG
(CHEMBL4094220)
Show SMILES CSc1nc(c(-c2ccnc(Nc3cccc(NC(=O)c4cccc(NC(=O)C=C)c4)c3)c2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C32H27FN6O2S/c1-4-28(40)36-24-8-5-7-22(17-24)31(41)37-26-10-6-9-25(19-26)35-27-18-21(15-16-34-27)30-29(38-32(42-3)39(30)2)20-11-13-23(33)14-12-20/h4-19H,1H2,2-3H3,(H,34,35)(H,36,40)(H,37,41)
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n/an/a 3n/an/an/an/an/an/a



Eberhard Karls Universit£t T£bingen

Curated by ChEMBL


Assay Description
Inhibition of recombinant 6x-His-tagged JNK3 (39 to 402 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as reduction in A...


J Med Chem 60: 594-607 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01180
BindingDB Entry DOI: 10.7270/Q2891854
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50234884
PNG
(CHEMBL4082212)
Show SMILES CSc1nc(c([nH]1)-c1ccnc(Nc2ccc(NC(=O)c3ccc(NC(=O)C=C)cc3)cc2)c1)-c1ccc(F)cc1
Show InChI InChI=1S/C31H25FN6O2S/c1-3-27(39)35-24-10-6-20(7-11-24)30(40)36-25-14-12-23(13-15-25)34-26-18-21(16-17-33-26)29-28(37-31(38-29)41-2)19-4-8-22(32)9-5-19/h3-18H,1H2,2H3,(H,33,34)(H,35,39)(H,36,40)(H,37,38)
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n/an/a 3n/an/an/an/an/an/a



Eberhard Karls Universit£t T£bingen

Curated by ChEMBL


Assay Description
Inhibition of recombinant 6x-His-tagged JNK3 (39 to 402 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as reduction in A...


J Med Chem 60: 594-607 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01180
BindingDB Entry DOI: 10.7270/Q2891854
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50234895
PNG
(CHEMBL4071770)
Show SMILES CSc1nc(c(-c2ccnc(Nc3cccc(NC(=O)c4cccc(NC(=O)C=C)c4C)c3)c2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C33H29FN6O2S/c1-5-29(41)38-27-11-7-10-26(20(27)2)32(42)37-25-9-6-8-24(19-25)36-28-18-22(16-17-35-28)31-30(39-33(43-4)40(31)3)21-12-14-23(34)15-13-21/h5-19H,1H2,2-4H3,(H,35,36)(H,37,42)(H,38,41)
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n/an/a 3n/an/an/an/an/an/a



Eberhard Karls Universit£t T£bingen

Curated by ChEMBL


Assay Description
Inhibition of recombinant 6x-His-tagged JNK3 (39 to 402 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as reduction in A...


J Med Chem 60: 594-607 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01180
BindingDB Entry DOI: 10.7270/Q2891854
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50352624
PNG
(CHEMBL1822305 | US9796706, Compound 139)
Show SMILES Cn1cnc(n1)-c1c(Br)csc1NC(=O)CN1C(=O)CCc2ncccc12
Show InChI InChI=1S/C17H15BrN6O2S/c1-23-9-20-16(22-23)15-10(18)8-27-17(15)21-13(25)7-24-12-3-2-6-19-11(12)4-5-14(24)26/h2-3,6,8-9H,4-5,7H2,1H3,(H,21,25)
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n/an/a 3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 using ser73 of c-jun as substrate preincubated for 15 mins measured after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 5521-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.100
BindingDB Entry DOI: 10.7270/Q29Z959K
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50314149
PNG
(3-(6-(2-chlorophenylamino)-1H-indazol-3-yl)-5-(4-(...)
Show SMILES CN(C)CCCC(=O)Nc1cc(cc(c1)-c1n[nH]c2cc(Nc3ccccc3Cl)ccc12)C(O)=O
Show InChI InChI=1S/C26H26ClN5O3/c1-32(2)11-5-8-24(33)29-19-13-16(12-17(14-19)26(34)35)25-20-10-9-18(15-23(20)30-31-25)28-22-7-4-3-6-21(22)27/h3-4,6-7,9-10,12-15,28H,5,8,11H2,1-2H3,(H,29,33)(H,30,31)(H,34,35)
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n/an/a 3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of JNK3


J Med Chem 53: 3005-12 (2010)


Article DOI: 10.1021/jm9003279
BindingDB Entry DOI: 10.7270/Q2KS6RP5
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50178827
PNG
((+)-N-(4-(2-(4-fluorophenylamino)pyridin-4-yl)pyri...)
Show SMILES Fc1ccc(Nc2cc(ccn2)-c2ccnc(NC(=O)C3CCOC3)c2)cc1
Show InChI InChI=1/C21H19FN4O2/c22-17-1-3-18(4-2-17)25-19-11-14(5-8-23-19)15-6-9-24-20(12-15)26-21(27)16-7-10-28-13-16/h1-6,8-9,11-12,16H,7,10,13H2,(H,23,25)(H,24,26,27)
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n/an/a 3n/an/an/an/an/an/a



AstraZeneca R&D Södertälje

Curated by ChEMBL


Assay Description
Inhibition of JNK3


Bioorg Med Chem Lett 16: 1397-401 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.039
BindingDB Entry DOI: 10.7270/Q2KP81R3
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50173169
PNG
(CHEMBL383799 | [(R)-2-(4-Fluoro-phenyl)-3-(2-propy...)
Show SMILES CCCNc1nccc(n1)-c1c(nc2CC[C@H](CO)n12)-c1ccc(F)cc1
Show InChI InChI=1S/C20H22FN5O/c1-2-10-22-20-23-11-9-16(24-20)19-18(13-3-5-14(21)6-4-13)25-17-8-7-15(12-27)26(17)19/h3-6,9,11,15,27H,2,7-8,10,12H2,1H3,(H,22,23,24)/t15-/m1/s1
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n/an/a 3n/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Inhibitory activity against c-Jun N-terminal kinase 3 at a concentration of 1.0 uM


Bioorg Med Chem Lett 15: 4666-70 (2005)


Article DOI: 10.1016/j.bmcl.2005.07.076
BindingDB Entry DOI: 10.7270/Q28G8K8K
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50271563
PNG
(CHEMBL482708 | N-cyclohexyl-4-(H-imidazo[1,2-a]pyr...)
Show SMILES CN(C1CCCCC1)c1nccc(n1)-c1cnc2ccccn12
Show InChI InChI=1S/C18H21N5/c1-22(14-7-3-2-4-8-14)18-19-11-10-15(21-18)16-13-20-17-9-5-6-12-23(16)17/h5-6,9-14H,2-4,7-8H2,1H3
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n/an/a 3n/an/an/an/an/an/a



UCB Pharma SA

Curated by ChEMBL


Assay Description
Inhibition of JNK3 (unknown origin)


Bioorg Med Chem Lett 18: 3291-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.039
BindingDB Entry DOI: 10.7270/Q2NZ87FX
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50211299
PNG
((3S)-N-(4-(2-(4-fluorophenylamino)pyridin-4-yl)pyr...)
Show SMILES Fc1ccc(Nc2cc(ccn2)-c2ccnc(NC(=O)[C@H]3CCOC3)c2)cc1
Show InChI InChI=1S/C21H19FN4O2/c22-17-1-3-18(4-2-17)25-19-11-14(5-8-23-19)15-6-9-24-20(12-15)26-21(27)16-7-10-28-13-16/h1-6,8-9,11-12,16H,7,10,13H2,(H,23,25)(H,24,26,27)/t16-/m0/s1
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n/an/a 3n/an/an/an/an/an/a



Aureus Pharma

Curated by ChEMBL


Assay Description
Inhibition of JNK3


Bioorg Med Chem 15: 4256-64 (2007)


Article DOI: 10.1016/j.bmc.2007.03.062
BindingDB Entry DOI: 10.7270/Q2T43SSD
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50169995
PNG
(2-(2-(4-methoxyphenethylamino)pyrimidin-4-yl)-2-(b...)
Show SMILES COc1ccc(CCNc2nccc(n2)C(C#N)c2nc3ccccc3s2)cc1
Show InChI InChI=1/C22H19N5OS/c1-28-16-8-6-15(7-9-16)10-12-24-22-25-13-11-18(27-22)17(14-23)21-26-19-4-2-3-5-20(19)29-21/h2-9,11,13,17H,10,12H2,1H3,(H,24,25,27)
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n/an/a 3.10n/an/an/an/an/an/a



Aureus Pharma

Curated by ChEMBL


Assay Description
Inhibition of JNK3


Bioorg Med Chem 15: 4256-64 (2007)


Article DOI: 10.1016/j.bmc.2007.03.062
BindingDB Entry DOI: 10.7270/Q2T43SSD
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50172919
PNG
(3-[6-(2-Chloro-phenylamino)-1H-indazol-3-yl]-benza...)
Show SMILES NC(=O)c1cccc(c1)-c1n[nH]c2cc(Nc3ccccc3Cl)ccc12
Show InChI InChI=1S/C20H15ClN4O/c21-16-6-1-2-7-17(16)23-14-8-9-15-18(11-14)24-25-19(15)12-4-3-5-13(10-12)20(22)26/h1-11,23H,(H2,22,26)(H,24,25)
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n/an/a 3.30n/an/an/an/an/an/a



AstraZeneca R&D Södertälje

Curated by ChEMBL


Assay Description
Inhibitory concentration against c-Jun N-terminal kinase 3


Bioorg Med Chem Lett 15: 5095-9 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.083
BindingDB Entry DOI: 10.7270/Q2JW8DFC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50172921
PNG
(3-[6-(2-Chloro-phenylamino)-1H-indazol-3-yl]-N-(3-...)
Show SMILES Clc1ccccc1Nc1ccc2c(n[nH]c2c1)-c1cccc(c1)C(=O)NCCCN1CCOCC1
Show InChI InChI=1S/C27H28ClN5O2/c28-23-7-1-2-8-24(23)30-21-9-10-22-25(18-21)31-32-26(22)19-5-3-6-20(17-19)27(34)29-11-4-12-33-13-15-35-16-14-33/h1-3,5-10,17-18,30H,4,11-16H2,(H,29,34)(H,31,32)
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n/an/a 3.40n/an/an/an/an/an/a



AstraZeneca R&D Södertälje

Curated by ChEMBL


Assay Description
Inhibitory concentration against c-Jun N-terminal kinase 3


Bioorg Med Chem Lett 15: 5095-9 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.083
BindingDB Entry DOI: 10.7270/Q2JW8DFC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50303639
PNG
(CHEMBL571626 | N-(4-(2-(4-(1H-1,2,3-Triazol-1-yl)p...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1ccnc(Nc2ccc(cc2)-n2ccnn2)n1
Show InChI InChI=1S/C19H17N7O2S/c1-29(27,28)24-16-4-2-14(3-5-16)18-10-11-20-19(23-18)22-15-6-8-17(9-7-15)26-13-12-21-25-26/h2-13,24H,1H3,(H,20,22,23)
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n/an/a 4n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of JNK3 by time resolved fluorescence assay


J Med Chem 53: 419-31 (2010)


Article DOI: 10.1021/jm901351f
BindingDB Entry DOI: 10.7270/Q23T9J6J
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50303639
PNG
(CHEMBL571626 | N-(4-(2-(4-(1H-1,2,3-Triazol-1-yl)p...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1ccnc(Nc2ccc(cc2)-n2ccnn2)n1
Show InChI InChI=1S/C19H17N7O2S/c1-29(27,28)24-16-4-2-14(3-5-16)18-10-11-20-19(23-18)22-15-6-8-17(9-7-15)26-13-12-21-25-26/h2-13,24H,1H3,(H,20,22,23)
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n/an/a 4n/an/an/an/an/an/a



Eberhard Karls Universit£t T£bingen

Curated by ChEMBL


Assay Description
Inhibition of JNK3 (unknown origin) by time-resolved fluorescence assay


J Med Chem 58: 72-95 (2015)


Article DOI: 10.1021/jm501212r
BindingDB Entry DOI: 10.7270/Q2JH3NVZ
More data for this
Ligand-Target Pair
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