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Found 897 hits Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase kinase kinase 5'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM50464991
PNG
(CHEMBL4283739)
Show SMILES COc1cc(C)c(cc1C(=O)Nc1cccc(n1)-c1nncn1C(C)C)S(N)(=O)=O
Show InChI InChI=1S/C19H22N6O4S/c1-11(2)25-10-21-24-18(25)14-6-5-7-17(22-14)23-19(26)13-9-16(30(20,27)28)12(3)8-15(13)29-4/h5-11H,1-4H3,(H2,20,27,28)(H,22,23,26)
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n/an/a 0.100n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length human GST-tagged ASK1 expressed in baculovirus expression system using STK3 peptide substrate preincubated for ...


Eur J Med Chem 145: 606-621 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM50464987
PNG
(CHEMBL4290518)
Show SMILES CCS(=O)(=O)Nc1ccc(OC)c(c1)C(=O)Nc1cccc(n1)-c1nncn1C(C)C
Show InChI InChI=1S/C20H24N6O4S/c1-5-31(28,29)25-14-9-10-17(30-4)15(11-14)20(27)23-18-8-6-7-16(22-18)19-24-21-12-26(19)13(2)3/h6-13,25H,5H2,1-4H3,(H,22,23,27)
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n/an/a 0.320n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length human GST-tagged ASK1 expressed in baculovirus expression system using STK3 peptide substrate preincubated for ...


Eur J Med Chem 145: 606-621 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM187363
PNG
(US9169243, 11 | US9908875, 11)
Show SMILES CNC(=O)C1CCN(CC1)c1cnc(cc1-n1cnc(c1)C1CC1)C(=O)Nc1csc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C27H30N10O2S/c1-28-25(38)17-6-8-35(9-7-17)22-11-29-19(10-21(22)36-12-20(30-14-36)16-2-3-16)26(39)32-23-13-40-27(33-23)24-34-31-15-37(24)18-4-5-18/h10-18H,2-9H2,1H3,(H,28,38)(H,32,39)
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n/an/a 0.400n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...


US Patent US9908875 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM50464992
PNG
(CHEMBL4294318)
Show SMILES COc1cc(C)c(cc1C(=O)Nc1cccc(n1)-c1nncn1C(C)C)C(N)=O
Show InChI InChI=1S/C20H22N6O3/c1-11(2)26-10-22-25-19(26)15-6-5-7-17(23-15)24-20(28)14-9-13(18(21)27)12(3)8-16(14)29-4/h5-11H,1-4H3,(H2,21,27)(H,23,24,28)
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n/an/a 0.420n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length human GST-tagged ASK1 expressed in baculovirus expression system using STK3 peptide substrate preincubated for ...


Eur J Med Chem 145: 606-621 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/s2
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n/an/a 0.690n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
Inhibition of ASK1 (unknown origin) by HTRF assay


J Nat Prod 81: 949-956 (2018)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM50245498
PNG
(CHEMBL4083562)
Show SMILES CC(n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CCCCC2)-n2cnc(c2)C2CC2)cs1)C(F)(F)F
Show InChI InChI=1/C25H26F3N9OS/c1-15(25(26,27)28)37-14-31-34-22(37)24-33-21(12-39-24)32-23(38)17-9-19(36-11-18(30-13-36)16-5-6-16)20(10-29-17)35-7-3-2-4-8-35/h9-16H,2-8H2,1H3,(H,32,38)
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n/an/a 0.700n/an/an/an/an/an/a



Taipei Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human ASK1 using STK3 peptide as substrate incubated for 30 mins followed by ATP addition measured for 3 hrs by TR-FRET ass...


J Med Chem 60: 527-553 (2017)


Article DOI: 10.1021/acs.jmedchem.6b00935
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM162322
PNG
(US10307427, Compound 13 | US9051313, 13)
Show SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CCCCC2)-n2cnc(c2)C2CC2)cs1)C(F)(F)F
Show InChI InChI=1/C25H26F3N9OS/c1-15(25(26,27)28)37-14-31-34-22(37)24-33-21(12-39-24)32-23(38)17-9-19(36-11-18(30-13-36)16-5-6-16)20(10-29-17)35-7-3-2-4-8-35/h9-16H,2-8H2,1H3,(H,32,38)/t15-/s2
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n/an/a 0.700n/an/an/an/an/an/a



Gildead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...


US Patent US9051313 (2015)


BindingDB Entry DOI: 10.7270/Q21N7ZVX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM162322
PNG
(US10307427, Compound 13 | US9051313, 13)
Show SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CCCCC2)-n2cnc(c2)C2CC2)cs1)C(F)(F)F
Show InChI InChI=1/C25H26F3N9OS/c1-15(25(26,27)28)37-14-31-34-22(37)24-33-21(12-39-24)32-23(38)17-9-19(36-11-18(30-13-36)16-5-6-16)20(10-29-17)35-7-3-2-4-8-35/h9-16H,2-8H2,1H3,(H,32,38)/t15-/s2
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n/an/a 0.700n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...


US Patent US10307427 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM187354
PNG
(US9169243, 2 | US9908875, 2)
Show SMILES O=C(Nc1csc(n1)-c1nncn1C1CC1)c1cc(c(cn1)N1CC(C1)C#N)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C24H22N10OS/c25-6-14-8-32(9-14)20-7-26-17(5-19(20)33-10-18(27-12-33)15-1-2-15)23(35)29-21-11-36-24(30-21)22-31-28-13-34(22)16-3-4-16/h5,7,10-16H,1-4,8-9H2,(H,29,35)
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n/an/a 0.900n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...


US Patent US9908875 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419047
PNG
(US10450301, Example 126)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cn2)C(=O)OCC(F)(F)F)n1
Show InChI InChI=1S/C21H21F3N8O4/c1-12(10-33)32-18(28-29-30-32)15-3-2-4-17(26-15)27-19(34)16-7-14-9-31(6-5-13(14)8-25-16)20(35)36-11-21(22,23)24/h2-4,7-8,12,33H,5-6,9-11H2,1H3,(H,26,27,34)/t12-/m1/s1
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n/an/a<1n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM419108
PNG
(US10450301, Example 187)
Show SMILES CCn1cc(CNC(=O)N2CCc3cnc(cc3C2)C(=O)Nc2cccc(n2)-c2nnnn2[C@H](C)CO)cn1
Show InChI InChI=1S/C25H29N11O3/c1-3-35-13-17(11-28-35)10-27-25(39)34-8-7-18-12-26-21(9-19(18)14-34)24(38)30-22-6-4-5-20(29-22)23-31-32-33-36(23)16(2)15-37/h4-6,9,11-13,16,37H,3,7-8,10,14-15H2,1-2H3,(H,27,39)(H,29,30,38)/t16-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...


US Patent US10450301 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM50464985
PNG
(CHEMBL4282644)
Show SMILES COc1ccc(cc1C(=O)Nc1cccc(n1)-c1nncn1C(C)C)C(N)=O
Show InChI InChI=1S/C19H20N6O3/c1-11(2)25-10-21-24-18(25)14-5-4-6-16(22-14)23-19(27)13-9-12(17(20)26)7-8-15(13)28-3/h4-11H,1-3H3,(H2,20,26)(H,22,23,27)
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n/an/a 1n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length human GST-tagged ASK1 expressed in baculovirus expression system using STK3 peptide substrate preincubated for ...


Eur J Med Chem 145: 606-621 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM187369
PNG
(US9169243, 17 | US9908875, 17)
Show SMILES O=C(Nc1csc(n1)-c1nncn1C1CC1)c1cc(c(cn1)N1CC2CC2C1)-n1cnc(c1)C1CC1
Show InChI InChI=1/C25H25N9OS/c35-24(29-22-11-36-25(30-22)23-31-28-13-34(23)17-3-4-17)18-6-20(33-10-19(27-12-33)14-1-2-14)21(7-26-18)32-8-15-5-16(15)9-32/h6-7,10-17H,1-5,8-9H2,(H,29,35)
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n/an/a 1.10n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...


US Patent US9908875 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM187385
PNG
(US9169243, 33 | US9908875, 33)
Show SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CCN(CC(F)(F)F)CC2)-n2cnc(c2)C2CC2)cs1)C(F)(F)F
Show InChI InChI=1/C26H26F6N10OS/c1-15(26(30,31)32)42-14-35-38-22(42)24-37-21(11-44-24)36-23(43)17-8-19(41-10-18(34-13-41)16-2-3-16)20(9-33-17)40-6-4-39(5-7-40)12-25(27,28)29/h8-11,13-16H,2-7,12H2,1H3,(H,36,43)/t15-/s2
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n/an/a 1.20n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...


US Patent US9908875 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM187376
PNG
(US9169243, 24 | US9908875, 24)
Show SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CC(C)(C2)C#N)-n2cnc(c2)C2CC2)cs1)C(F)(F)F
Show InChI InChI=1/C25H23F3N10OS/c1-14(25(26,27)28)38-13-32-35-21(38)23-34-20(8-40-23)33-22(39)16-5-18(36-7-17(31-12-36)15-3-4-15)19(6-30-16)37-10-24(2,9-29)11-37/h5-8,12-15H,3-4,10-11H2,1-2H3,(H,33,39)/t14-/s2
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n/an/a 1.40n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...


US Patent US9908875 (2018)

More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM162310
PNG
(US10307427, Compound 1 | US9051313, 1)
Show SMILES O=C(Nc1csc(n1)-c1nncn1C1CC1)c1cc(c(cn1)N1CCOCC1)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C24H25N9O2S/c34-23(28-21-12-36-24(29-21)22-30-27-14-33(22)16-3-4-16)17-9-19(32-11-18(26-13-32)15-1-2-15)20(10-25-17)31-5-7-35-8-6-31/h9-16H,1-8H2,(H,28,34)
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n/an/a 1.44n/an/an/an/an/an/a



Gildead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...


US Patent US9051313 (2015)


BindingDB Entry DOI: 10.7270/Q21N7ZVX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM162310
PNG
(US10307427, Compound 1 | US9051313, 1)
Show SMILES O=C(Nc1csc(n1)-c1nncn1C1CC1)c1cc(c(cn1)N1CCOCC1)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C24H25N9O2S/c34-23(28-21-12-36-24(29-21)22-30-27-14-33(22)16-3-4-16)17-9-19(32-11-18(26-13-32)15-1-2-15)20(10-25-17)31-5-7-35-8-6-31/h9-16H,1-8H2,(H,28,34)
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Gilead Sciences Inc

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...


US Patent US10307427 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM410042
PNG
(1-[3-(4-Cyclopropylimidazol-1-yl)cyclobutyl]-3-[6-...)
Show SMILES CC(C)n1cnnc1-c1cccc(n1)N1CCN(C2CC(C2)n2cnc(c2)C2CC2)C1=O
Show InChI InChI=1S/C23H28N8O/c1-15(2)31-14-25-27-22(31)19-4-3-5-21(26-19)30-9-8-29(23(30)32)18-10-17(11-18)28-12-20(24-13-28)16-6-7-16/h3-5,12-18H,6-11H2,1-2H3
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n/an/a 1.47n/an/an/an/an/an/a



ELI LILLY AND COMPANY

US Patent


Assay Description
The assay is done using an ADP-Glo Kinase Assay Kit (Promega, Catalog #V9102) according to the manufacturer's protocol with the following modific...


US Patent US10370352 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM50464986
PNG
(CHEMBL4278211)
Show SMILES COc1ccc(cc1C(=O)Nc1cccc(n1)-c1nncn1C(C)C)S(N)(=O)=O
Show InChI InChI=1S/C18H20N6O4S/c1-11(2)24-10-20-23-17(24)14-5-4-6-16(21-14)22-18(25)13-9-12(29(19,26)27)7-8-15(13)28-3/h4-11H,1-3H3,(H2,19,26,27)(H,21,22,25)
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n/an/a 1.5n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length human GST-tagged ASK1 expressed in baculovirus expression system using STK3 peptide substrate preincubated for ...


Eur J Med Chem 145: 606-621 (2018)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM187384
PNG
(US9169243, 32 | US9908875, 32)
Show SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CCC(CC2)C(F)(F)F)-n2cnc(c2)C2CC2)cs1)C(F)(F)F
Show InChI InChI=1/C26H25F6N9OS/c1-14(25(27,28)29)41-13-35-38-22(41)24-37-21(11-43-24)36-23(42)17-8-19(40-10-18(34-12-40)15-2-3-15)20(9-33-17)39-6-4-16(5-7-39)26(30,31)32/h8-16H,2-7H2,1H3,(H,36,42)/t14-/s2
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Gilead Sciences Inc

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...


US Patent US9908875 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM162311
PNG
(US10307427, Compound 2 | US9051313, 2)
Show SMILES CC1(O)CN(C1)c1cnc(cc1-n1cnc(c1)C1CC1)C(=O)Nc1csc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C24H25N9O2S/c1-24(35)10-32(11-24)19-7-25-16(6-18(19)31-8-17(26-12-31)14-2-3-14)22(34)28-20-9-36-23(29-20)21-30-27-13-33(21)15-4-5-15/h6-9,12-15,35H,2-5,10-11H2,1H3,(H,28,34)
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n/an/a 1.58n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...


US Patent US10307427 (2019)

More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM162311
PNG
(US10307427, Compound 2 | US9051313, 2)
Show SMILES CC1(O)CN(C1)c1cnc(cc1-n1cnc(c1)C1CC1)C(=O)Nc1csc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C24H25N9O2S/c1-24(35)10-32(11-24)19-7-25-16(6-18(19)31-8-17(26-12-31)14-2-3-14)22(34)28-20-9-36-23(29-20)21-30-27-13-33(21)15-4-5-15/h6-9,12-15,35H,2-5,10-11H2,1H3,(H,28,34)
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Gildead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...


US Patent US9051313 (2015)


BindingDB Entry DOI: 10.7270/Q21N7ZVX
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM162313
PNG
(US9051313, 4)
Show SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CC(C)(O)C2)-n2cnc(c2)C2CC2)cs1)C(F)(F)F
Show InChI InChI=1/C24H24F3N9O2S/c1-13(24(25,26)27)36-12-30-33-20(36)22-32-19(8-39-22)31-21(37)15-5-17(34-7-16(29-11-34)14-3-4-14)18(6-28-15)35-9-23(2,38)10-35/h5-8,11-14,38H,3-4,9-10H2,1-2H3,(H,31,37)/t13-/s2
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n/an/a 1.69n/an/an/an/an/an/a



Gildead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...


US Patent US9051313 (2015)


BindingDB Entry DOI: 10.7270/Q21N7ZVX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM394380
PNG
((S)-4-(4-cyclopropyl-1H-imidazol-1-yl)-5-(3-hydrox...)
Show SMILES CC(n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CC(C)(O)C2)-n2cnc(c2)C2CC2)cs1)C(F)(F)F
Show InChI InChI=1S/C24H24F3N9O2S/c1-13(24(25,26)27)36-12-30-33-20(36)22-32-19(8-39-22)31-21(37)15-5-17(34-7-16(29-11-34)14-3-4-14)18(6-28-15)35-9-23(2,38)10-35/h5-8,11-14,38H,3-4,9-10H2,1-2H3,(H,31,37)
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Gilead Sciences Inc

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...


US Patent US10307427 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM187381
PNG
(US9169243, 29 | US9908875, 29)
Show SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CCC(CC2)C#N)-n2cnc(c2)C2CC2)cs1)C(F)(F)F
Show InChI InChI=1/C26H25F3N10OS/c1-15(26(27,28)29)39-14-33-36-23(39)25-35-22(12-41-25)34-24(40)18-8-20(38-11-19(32-13-38)17-2-3-17)21(10-31-18)37-6-4-16(9-30)5-7-37/h8,10-17H,2-7H2,1H3,(H,34,40)/t15-/s2
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Gilead Sciences Inc

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...


US Patent US9908875 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM187378
PNG
(US9169243, 26 | US9908875, 26)
Show SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CC(C2)C(F)F)-n2cnc(c2)C2CC2)cs1)C(F)(F)F
Show InChI InChI=1/C24H22F5N9OS/c1-12(24(27,28)29)38-11-32-35-21(38)23-34-19(9-40-23)33-22(39)15-4-17(37-8-16(31-10-37)13-2-3-13)18(5-30-15)36-6-14(7-36)20(25)26/h4-5,8-14,20H,2-3,6-7H2,1H3,(H,33,39)/t12-/s2
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Gilead Sciences Inc

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...


US Patent US9908875 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM187386
PNG
(US9169243, 34 | US9908875, 34)
Show SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CCC(F)CC2)-n2cnc(c2)C2CC2)cs1)C(F)(F)F
Show InChI InChI=1/C25H25F4N9OS/c1-14(25(27,28)29)38-13-32-35-22(38)24-34-21(11-40-24)33-23(39)17-8-19(37-10-18(31-12-37)15-2-3-15)20(9-30-17)36-6-4-16(26)5-7-36/h8-16H,2-7H2,1H3,(H,33,39)/t14-/s2
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Gilead Sciences Inc

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...


US Patent US9908875 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM394384
PNG
((S)-5-(azetidin-1-yl)-4-(4-cyclopropyl-1H-imidazol...)
Show SMILES CC(n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CCC2)-n2cnc(c2)C2CC2)cs1)C(F)(F)F
Show InChI InChI=1S/C23H22F3N9OS/c1-13(23(24,25)26)35-12-29-32-20(35)22-31-19(10-37-22)30-21(36)15-7-17(18(8-27-15)33-5-2-6-33)34-9-16(28-11-34)14-3-4-14/h7-14H,2-6H2,1H3,(H,30,36)
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Gilead Sciences Inc

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...


US Patent US10307427 (2019)

More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM162316
PNG
(US9051313, 7)
Show SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CCC2)-n2cnc(c2)C2CC2)cs1)C(F)(F)F
Show InChI InChI=1/C23H22F3N9OS/c1-13(23(24,25)26)35-12-29-32-20(35)22-31-19(10-37-22)30-21(36)15-7-17(18(8-27-15)33-5-2-6-33)34-9-16(28-11-34)14-3-4-14/h7-14H,2-6H2,1H3,(H,30,36)/t13-/s2
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Gildead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...


US Patent US9051313 (2015)


BindingDB Entry DOI: 10.7270/Q21N7ZVX
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM162323
PNG
(US10307427, Compound 14 | US9051313, 14)
Show SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CCC(C)(O)CC2)-n2cnc(c2)C2CC2)cs1)C(F)(F)F
Show InChI InChI=1/C26H28F3N9O2S/c1-15(26(27,28)29)38-14-32-35-22(38)24-34-21(12-41-24)33-23(39)17-9-19(37-11-18(31-13-37)16-3-4-16)20(10-30-17)36-7-5-25(2,40)6-8-36/h9-16,40H,3-8H2,1-2H3,(H,33,39)/t15-/s2
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n/an/a 1.80n/an/an/an/an/an/a



Gildead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...


US Patent US9051313 (2015)


BindingDB Entry DOI: 10.7270/Q21N7ZVX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM187394
PNG
(US9169243, 42 | US9908875, 42)
Show SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CCN(CC2)C2CC2)-n2cnc(c2)C2CC2)cs1)C(F)(F)F
Show InChI InChI=1/C27H29F3N10OS/c1-16(27(28,29)30)40-15-33-36-24(40)26-35-23(13-42-26)34-25(41)19-10-21(39-12-20(32-14-39)17-2-3-17)22(11-31-19)38-8-6-37(7-9-38)18-4-5-18/h10-18H,2-9H2,1H3,(H,34,41)/t16-/s2
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Gilead Sciences Inc

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...


US Patent US9908875 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM187356
PNG
(US9169243, 4 | US9908875, 4)
Show SMILES COC1(C)CN(C1)c1cnc(cc1-n1cnc(c1)C1CC1)C(=O)Nc1csc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C25H27N9O2S/c1-25(36-2)11-33(12-25)20-8-26-17(7-19(20)32-9-18(27-13-32)15-3-4-15)23(35)29-21-10-37-24(30-21)22-31-28-14-34(22)16-5-6-16/h7-10,13-16H,3-6,11-12H2,1-2H3,(H,29,35)
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Gilead Sciences Inc

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...


US Patent US9908875 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM162323
PNG
(US10307427, Compound 14 | US9051313, 14)
Show SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CCC(C)(O)CC2)-n2cnc(c2)C2CC2)cs1)C(F)(F)F
Show InChI InChI=1/C26H28F3N9O2S/c1-15(26(27,28)29)38-14-32-35-22(38)24-34-21(12-41-24)33-23(39)17-9-19(37-11-18(31-13-37)16-3-4-16)20(10-30-17)36-7-5-25(2,40)6-8-36/h9-16,40H,3-8H2,1-2H3,(H,33,39)/t15-/s2
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Gilead Sciences Inc

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...


US Patent US10307427 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM187395
PNG
(US9169243, 43 | US9908875, 43)
Show SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CCN(CC3CC3)CC2)-n2cnc(c2)C2CC2)cs1)C(F)(F)F
Show InChI InChI=1/C28H31F3N10OS/c1-17(28(29,30)31)41-16-34-37-25(41)27-36-24(14-43-27)35-26(42)20-10-22(40-13-21(33-15-40)19-4-5-19)23(11-32-20)39-8-6-38(7-9-39)12-18-2-3-18/h10-11,13-19H,2-9,12H2,1H3,(H,35,42)/t17-/s2
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Gilead Sciences Inc

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...


US Patent US9908875 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM375518
PNG
(4-(4-cyclopropyl-1H-imidazol-1-yl)-5- (hexahydropy...)
Show SMILES C[C@H](n1cnnc1-c1nc(cs1)N(N1CC2CCCN2C(C1)n1cnc(c1)C1CC1)C(=O)c1ccccn1)C(F)(F)F
Show InChI InChI=1S/C27H29F3N10OS/c1-17(27(28,29)30)39-16-33-35-24(39)25-34-22(14-42-25)40(26(41)20-6-2-3-9-31-20)37-11-19-5-4-10-38(19)23(13-37)36-12-21(32-15-36)18-7-8-18/h2-3,6,9,12,14-19,23H,4-5,7-8,10-11,13H2,1H3/t17-,19?,23?/m0/s1
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Gilead Sciences Inc

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...


US Patent US9908875 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM410045
PNG
(1-(3-(4-(tert-Butyl)-1H-imidazol-1-yl)cyclobutyl)-...)
Show SMILES CC(C)n1cnnc1-c1cccc(n1)N1CCN(C2CC(C2)n2cnc(c2)C(C)(C)C)C1=O
Show InChI InChI=1S/C24H32N8O/c1-16(2)32-15-26-28-22(32)19-7-6-8-21(27-19)31-10-9-30(23(31)33)18-11-17(12-18)29-13-20(25-14-29)24(3,4)5/h6-8,13-18H,9-12H2,1-5H3
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n/an/a 1.84n/an/an/an/an/an/a



ELI LILLY AND COMPANY

US Patent


Assay Description
The assay is done using an ADP-Glo Kinase Assay Kit (Promega, Catalog #V9102) according to the manufacturer's protocol with the following modific...


US Patent US10370352 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM394381
PNG
((S)-4-(4-cyclopropyl-1H-imidazol-1-yl)-5-(dimethyl...)
Show SMILES CC(n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N(C)C)-n2cnc(c2)C2CC2)cs1)C(F)(F)F
Show InChI InChI=1S/C22H22F3N9OS/c1-12(22(23,24)25)34-11-28-31-19(34)21-30-18(9-36-21)29-20(35)14-6-16(17(7-26-14)32(2)3)33-8-15(27-10-33)13-4-5-13/h6-13H,4-5H2,1-3H3,(H,29,35)
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Gilead Sciences Inc

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...


US Patent US10307427 (2019)

More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM162314
PNG
(US9051313, 5)
Show SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N(C)C)-n2cnc(c2)C2CC2)cs1)C(F)(F)F
Show InChI InChI=1/C22H22F3N9OS/c1-12(22(23,24)25)34-11-28-31-19(34)21-30-18(9-36-21)29-20(35)14-6-16(17(7-26-14)32(2)3)33-8-15(27-10-33)13-4-5-13/h6-13H,4-5H2,1-3H3,(H,29,35)/t12-/s2
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Gildead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...


US Patent US9051313 (2015)


BindingDB Entry DOI: 10.7270/Q21N7ZVX
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM162318
PNG
(US10307427, Compound 9 | US9051313, 9)
Show SMILES O=C(Nc1csc(n1)-c1nncn1C1CC1)c1cc(c(cn1)N1CCCC1)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C24H25N9OS/c34-23(28-21-12-35-24(29-21)22-30-27-14-33(22)16-5-6-16)17-9-19(20(10-25-17)31-7-1-2-8-31)32-11-18(26-13-32)15-3-4-15/h9-16H,1-8H2,(H,28,34)
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Gildead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...


US Patent US9051313 (2015)


BindingDB Entry DOI: 10.7270/Q21N7ZVX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM187380
PNG
(US9169243, 28 | US9908875, 28)
Show SMILES COC1CCN(C1)c1cnc(cc1-n1cnc(c1)C1CC1)C(=O)Nc1csc(n1)-c1nncn1[C@@H](C)C(F)(F)F
Show InChI InChI=1/C25H26F3N9O2S/c1-14(25(26,27)28)37-13-31-34-22(37)24-33-21(11-40-24)32-23(38)17-7-19(36-10-18(30-12-36)15-3-4-15)20(8-29-17)35-6-5-16(9-35)39-2/h7-8,10-16H,3-6,9H2,1-2H3,(H,32,38)/t14-,16?/s2
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Gilead Sciences Inc

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...


US Patent US9908875 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM187373
PNG
(US9169243, 21 | US9908875, 21)
Show SMILES O=C(Nc1csc(n1)-c1nncn1C1CC1)c1cc(c(cn1)N1CCC2(COC2)CC1)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C27H29N9O2S/c37-25(31-23-12-39-26(32-23)24-33-30-16-36(24)18-3-4-18)19-9-21(35-11-20(29-15-35)17-1-2-17)22(10-28-19)34-7-5-27(6-8-34)13-38-14-27/h9-12,15-18H,1-8,13-14H2,(H,31,37)
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Gilead Sciences Inc

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...


US Patent US9908875 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM187388
PNG
(US9169243, 36 | US9908875, 36)
Show SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CCCOCC2)-n2cnc(c2)C2CC2)cs1)C(F)(F)F
Show InChI InChI=1/C25H26F3N9O2S/c1-15(25(26,27)28)37-14-31-34-22(37)24-33-21(12-40-24)32-23(38)17-9-19(36-11-18(30-13-36)16-3-4-16)20(10-29-17)35-5-2-7-39-8-6-35/h9-16H,2-8H2,1H3,(H,32,38)/t15-/s2
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Gilead Sciences Inc

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...


US Patent US9908875 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM187355
PNG
(US9169243, 3 | US9908875, 3)
Show SMILES CC1(CN(C1)c1cnc(cc1-n1cnc(c1)C1CC1)C(=O)Nc1csc(n1)-c1nncn1C1CC1)C#N
Show InChI InChI=1S/C25H24N10OS/c1-25(10-26)11-34(12-25)20-7-27-17(6-19(20)33-8-18(28-13-33)15-2-3-15)23(36)30-21-9-37-24(31-21)22-32-29-14-35(22)16-4-5-16/h6-9,13-16H,2-5,11-12H2,1H3,(H,30,36)
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Gilead Sciences Inc

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...


US Patent US9908875 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM162318
PNG
(US10307427, Compound 9 | US9051313, 9)
Show SMILES O=C(Nc1csc(n1)-c1nncn1C1CC1)c1cc(c(cn1)N1CCCC1)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C24H25N9OS/c34-23(28-21-12-35-24(29-21)22-30-27-14-33(22)16-5-6-16)17-9-19(20(10-25-17)31-7-1-2-8-31)32-11-18(26-13-32)15-3-4-15/h9-16H,1-8H2,(H,28,34)
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Gilead Sciences Inc

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...


US Patent US10307427 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM187393
PNG
(US9169243, 41 | US9908875, 41)
Show SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CC(C2)N2CCOCC2)-n2cnc(c2)C2CC2)cs1)C(F)(F)F
Show InChI InChI=1/C27H29F3N10O2S/c1-16(27(28,29)30)40-15-33-36-24(40)26-35-23(13-43-26)34-25(41)19-8-21(39-12-20(32-14-39)17-2-3-17)22(9-31-19)38-10-18(11-38)37-4-6-42-7-5-37/h8-9,12-18H,2-7,10-11H2,1H3,(H,34,41)/t16-/s2
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Gilead Sciences Inc

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...


US Patent US9908875 (2018)

More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM162321
PNG
(US10307427, Compound 12 | US9051313, 12)
Show SMILES O=C(Nc1csc(n1)-c1nncn1C1CC1)c1cc(c(cn1)N1CCCCC1)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C25H27N9OS/c35-24(29-22-13-36-25(30-22)23-31-28-15-34(23)17-6-7-17)18-10-20(33-12-19(27-14-33)16-4-5-16)21(11-26-18)32-8-2-1-3-9-32/h10-17H,1-9H2,(H,29,35)
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Gildead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...


US Patent US9051313 (2015)


BindingDB Entry DOI: 10.7270/Q21N7ZVX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (MAP3K5)


(Homo sapiens (Human))
BDBM128404
PNG
(US8802695, 20)
Show SMILES CCn1cc(Br)c2cnc(NC(=O)c3ccc(cc3)[C@@](C)(O)CO)cc12
Show InChI InChI=1/C19H20BrN3O3/c1-3-23-10-15(20)14-9-21-17(8-16(14)23)22-18(25)12-4-6-13(7-5-12)19(2,26)11-24/h4-10,24,26H,3,11H2,1-2H3,(H,21,22,25)/t19-/s2
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
The test compounds (2.5 μL) dissolved in DMSO were added to wells containing 37.5 μL of the reaction solution (25 mM HEPES (pH 7.5), 10 mM ...


US Patent US8802695 (2014)


BindingDB Entry DOI: 10.7270/Q27W69WD
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM187377
PNG
(US9169243, 25 | US9908875, 25)
Show SMILES COC1(C)CN(C1)c1cnc(cc1-n1cnc(c1)C1CC1)C(=O)Nc1csc(n1)-c1nncn1[C@@H](C)C(F)(F)F
Show InChI InChI=1/C25H26F3N9O2S/c1-14(25(26,27)28)37-13-31-34-21(37)23-33-20(9-40-23)32-22(38)16-6-18(35-8-17(30-12-35)15-4-5-15)19(7-29-16)36-10-24(2,11-36)39-3/h6-9,12-15H,4-5,10-11H2,1-3H3,(H,32,38)/t14-/s2
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Gilead Sciences Inc

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...


US Patent US9908875 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (MAP3K5)


(Homo sapiens (Human))
BDBM128406
PNG
(US8802695, 22)
Show SMILES C[C@](O)(CO)c1ccc(cc1)C(=O)Nc1cc2n(cc(Br)c2cn1)C1CC1
Show InChI InChI=1/C20H20BrN3O3/c1-20(27,11-25)13-4-2-12(3-5-13)19(26)23-18-8-17-15(9-22-18)16(21)10-24(17)14-6-7-14/h2-5,8-10,14,25,27H,6-7,11H2,1H3,(H,22,23,26)/t20-/s2
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Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
The test compounds (2.5 μL) dissolved in DMSO were added to wells containing 37.5 μL of the reaction solution (25 mM HEPES (pH 7.5), 10 mM ...


US Patent US8802695 (2014)


BindingDB Entry DOI: 10.7270/Q27W69WD
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM162321
PNG
(US10307427, Compound 12 | US9051313, 12)
Show SMILES O=C(Nc1csc(n1)-c1nncn1C1CC1)c1cc(c(cn1)N1CCCCC1)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C25H27N9OS/c35-24(29-22-13-36-25(30-22)23-31-28-15-34(23)17-6-7-17)18-10-20(33-12-19(27-14-33)16-4-5-16)21(11-26-18)32-8-2-1-3-9-32/h10-17H,1-9H2,(H,29,35)
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Gilead Sciences Inc

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...


US Patent US10307427 (2019)

More data for this
Ligand-Target Pair
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