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Found 711 hits Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase kinase kinase kinase 1'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM50453462
PNG
(CHEMBL4214886)
Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2ccsc2[nH]c1=O
Show InChI InChI=1S/C19H18N6OS/c1-24-5-7-25(8-6-24)11-2-3-13-14(10-11)22-17(21-13)15-16(20)12-4-9-27-19(12)23-18(15)26/h2-4,9-10H,5-8,20H2,1H3/b17-15-
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TBA

Assay Description
Inhibition of N-terminal GST-tagged human HPK1 (1 to 346 residues) after 30 mins in presence of ATP by indirect ELISA


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM50453461
PNG
(CHEMBL4213767)
Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2sccc2[nH]c1=O
Show InChI InChI=1S/C19H18N6OS/c1-24-5-7-25(8-6-24)11-2-3-12-14(10-11)22-18(21-12)15-16(20)17-13(4-9-27-17)23-19(15)26/h2-4,9-10H,5-8,20H2,1H3/b18-15-
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TBA

Assay Description
Inhibition of N-terminal GST-tagged human HPK1 (1 to 346 residues) after 30 mins in presence of ATP by indirect ELISA


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM283593
PNG
(N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)- 2-((...)
Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1ccnc(Cc2cc(CN)c3ncc(Cl)cc3c2)c1
Show InChI InChI=1S/C25H25ClN6O/c1-14-5-23(28)32-15(2)22(14)13-31-25(33)17-3-4-29-21(10-17)8-16-6-18-9-20(26)12-30-24(18)19(7-16)11-27/h3-7,9-10,12H,8,11,13,27H2,1-2H3,(H2,28,32)(H,31,33)
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n/an/a<100n/an/an/an/an/an/a



LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...


US Patent US10308637 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM283595
PNG
(N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)- 2-((...)
Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1ccnc(Cc2ccc3ncc(cc3c2)C2CC2)c1
Show InChI InChI=1S/C27H27N5O/c1-16-9-26(28)32-17(2)24(16)15-31-27(33)20-7-8-29-23(13-20)11-18-3-6-25-21(10-18)12-22(14-30-25)19-4-5-19/h3,6-10,12-14,19H,4-5,11,15H2,1-2H3,(H2,28,32)(H,31,33)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...


US Patent US10308637 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM283596
PNG
(N-((6-amino-2-methylpyridin-3-yl)methyl)-2- ((3-cy...)
Show SMILES Cc1nc(N)ccc1CNC(=O)c1ccnc(Cc2ccc3ncc(cc3c2)C2CC2)c1
Show InChI InChI=1S/C26H25N5O/c1-16-20(5-7-25(27)31-16)14-30-26(32)19-8-9-28-23(13-19)11-17-2-6-24-21(10-17)12-22(15-29-24)18-3-4-18/h2,5-10,12-13,15,18H,3-4,11,14H2,1H3,(H2,27,31)(H,30,32)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...


US Patent US10308637 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM283597
PNG
(N-((3-chloro-6-fluoro-1H-indol-5-yl)methyl)-2- ((3...)
Show SMILES Fc1cc2[nH]cc(Cl)c2cc1CNC(=O)c1ccnc(Cc2ccc3ncc(cc3c2)C2CC2)c1
Show InChI InChI=1S/C28H22ClFN4O/c29-24-15-33-27-12-25(30)21(11-23(24)27)14-34-28(35)18-5-6-31-22(10-18)8-16-1-4-26-19(7-16)9-20(13-32-26)17-2-3-17/h1,4-7,9-13,15,17,33H,2-3,8,14H2,(H,34,35)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...


US Patent US10308637 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM283598
PNG
(N-((3-chloro-1H-pyrrolo[2,3-b]pyridin-5- yl)methyl...)
Show SMILES Clc1c[nH]c2ncc(CNC(=O)c3ccnc(Cc4ccc5ncc(cc5c4)C4CC4)c3)cc12
Show InChI InChI=1S/C27H22ClN5O/c28-24-15-32-26-23(24)9-17(12-31-26)13-33-27(34)19-5-6-29-22(11-19)8-16-1-4-25-20(7-16)10-21(14-30-25)18-2-3-18/h1,4-7,9-12,14-15,18H,2-3,8,13H2,(H,31,32)(H,33,34)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...


US Patent US10308637 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM283599
PNG
(N-((1-aminoisoquinolin-6-yl)methyl)-2-((3- cyclopr...)
Show SMILES Nc1nccc2cc(CNC(=O)c3ccnc(Cc4ccc5ncc(cc5c4)C4CC4)c3)ccc12
Show InChI InChI=1S/C29H25N5O/c30-28-26-5-1-19(12-21(26)7-10-32-28)16-34-29(35)22-8-9-31-25(15-22)13-18-2-6-27-23(11-18)14-24(17-33-27)20-3-4-20/h1-2,5-12,14-15,17,20H,3-4,13,16H2,(H2,30,32)(H,34,35)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...


US Patent US10308637 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM283600
PNG
(N-((3-chloro-4-fluoro-1H-indol-5-yl)methyl)-2- ((3...)
Show SMILES Fc1c(CNC(=O)c2ccnc(Cc3ccc4ncc(cc4c3)C3CC3)c2)ccc2[nH]cc(Cl)c12
Show InChI InChI=1S/C28H22ClFN4O/c29-23-15-33-25-6-4-19(27(30)26(23)25)13-34-28(35)18-7-8-31-22(12-18)10-16-1-5-24-20(9-16)11-21(14-32-24)17-2-3-17/h1,4-9,11-12,14-15,17,33H,2-3,10,13H2,(H,34,35)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...


US Patent US10308637 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM283601
PNG
(N-((5-chloro-1H-indazol-3-yl)methyl)-2-((3- cyclop...)
Show SMILES Clc1ccc2[nH]nc(CNC(=O)c3ccnc(Cc4ccc5ncc(cc5c4)C4CC4)c3)c2c1
Show InChI InChI=1S/C27H22ClN5O/c28-21-4-6-25-23(13-21)26(33-32-25)15-31-27(34)18-7-8-29-22(12-18)10-16-1-5-24-19(9-16)11-20(14-30-24)17-2-3-17/h1,4-9,11-14,17H,2-3,10,15H2,(H,31,34)(H,32,33)
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n/an/a<100n/an/an/an/an/an/a



LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...


US Patent US10308637 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM283606
PNG
(N-((6-amino-2-methylpyridin-3-yl)methyl)-2- ((8-(a...)
Show SMILES Cc1nc(N)ccc1CNC(=O)c1ccnc(Cc2cc(CN)c3ncc(Cl)cc3c2)c1
Show InChI InChI=1S/C24H23ClN6O/c1-14-17(2-3-22(27)31-14)12-30-24(32)16-4-5-28-21(10-16)8-15-6-18-9-20(25)13-29-23(18)19(7-15)11-26/h2-7,9-10,13H,8,11-12,26H2,1H3,(H2,27,31)(H,30,32)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...


US Patent US10308637 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM283607
PNG
(N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)- 2-((...)
Show SMILES CC(C)c1cnc2ccc(Cc3cc(ccn3)C(=O)NCc3c(C)cc(N)nc3C)cc2c1
Show InChI InChI=1S/C27H29N5O/c1-16(2)22-12-21-10-19(5-6-25(21)30-14-22)11-23-13-20(7-8-29-23)27(33)31-15-24-17(3)9-26(28)32-18(24)4/h5-10,12-14,16H,11,15H2,1-4H3,(H2,28,32)(H,31,33)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...


US Patent US10308637 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM283608
PNG
(N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)- 2-((...)
Show SMILES CCCc1cnc2ccc(Cc3cc(ccn3)C(=O)NCc3c(C)cc(N)nc3C)cc2c1
Show InChI InChI=1S/C27H29N5O/c1-4-5-20-12-22-11-19(6-7-25(22)30-15-20)13-23-14-21(8-9-29-23)27(33)31-16-24-17(2)10-26(28)32-18(24)3/h6-12,14-15H,4-5,13,16H2,1-3H3,(H2,28,32)(H,31,33)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...


US Patent US10308637 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM283610
PNG
(N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)- 2-((...)
Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1ccnc(Cc2ccc3ncc(CO)cc3c2)c1
Show InChI InChI=1S/C25H25N5O2/c1-15-7-24(26)30-16(2)22(15)13-29-25(32)19-5-6-27-21(11-19)10-17-3-4-23-20(8-17)9-18(14-31)12-28-23/h3-9,11-12,31H,10,13-14H2,1-2H3,(H2,26,30)(H,29,32)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...


US Patent US10308637 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM283615
PNG
(N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)- 2-((...)
Show SMILES CC(O)c1cnc2ccc(Cc3cc(ccn3)C(=O)NCc3c(C)cc(N)nc3C)cc2c1
Show InChI InChI=1/C26H27N5O2/c1-15-8-25(27)31-16(2)23(15)14-30-26(33)19-6-7-28-22(12-19)10-18-4-5-24-20(9-18)11-21(13-29-24)17(3)32/h4-9,11-13,17,32H,10,14H2,1-3H3,(H2,27,31)(H,30,33)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...


US Patent US10308637 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM283617
PNG
(N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)- 2-((...)
Show SMILES COc1cnc2ccc(Cc3cc(ccn3)C(=O)NCc3c(C)cc(N)nc3C)cc2c1
Show InChI InChI=1S/C25H25N5O2/c1-15-8-24(26)30-16(2)22(15)14-29-25(31)18-6-7-27-20(11-18)10-17-4-5-23-19(9-17)12-21(32-3)13-28-23/h4-9,11-13H,10,14H2,1-3H3,(H2,26,30)(H,29,31)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...


US Patent US10308637 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM283618
PNG
(N-((6-amino-2-methylpyridin-3-yl)methyl)-2- ((3-me...)
Show SMILES COc1cnc2ccc(Cc3cc(ccn3)C(=O)NCc3ccc(N)nc3C)cc2c1
Show InChI InChI=1S/C24H23N5O2/c1-15-18(4-6-23(25)29-15)13-28-24(30)17-7-8-26-20(11-17)10-16-3-5-22-19(9-16)12-21(31-2)14-27-22/h3-9,11-12,14H,10,13H2,1-2H3,(H2,25,29)(H,28,30)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...


US Patent US10308637 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM283424
PNG
(2-((8-cyano-3-methylquinolin-6-yl)methyl)-N- ((6-f...)
Show SMILES Cc1cnc2c(cc(Cc3cc(ccn3)C(=O)NCc3cc4cc[nH]c4cc3F)cc2c1)C#N
Show InChI InChI=1S/C27H20FN5O/c1-16-6-20-7-17(8-21(13-29)26(20)32-14-16)9-23-11-19(3-4-30-23)27(34)33-15-22-10-18-2-5-31-25(18)12-24(22)28/h2-8,10-12,14,31H,9,15H2,1H3,(H,33,34)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...


US Patent US10308637 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM283425
PNG
(6-((4-(((6-amino-2,4-dimethylpyridin-3- yl)methyl)...)
Show SMILES Cc1cnc2c(cc(Cc3cc(ccn3)C(=O)NCc3c(C)cc(N)nc3C)cc2c1)C(N)=O
Show InChI InChI=1S/C26H26N6O2/c1-14-6-19-8-17(10-21(25(28)33)24(19)30-12-14)9-20-11-18(4-5-29-20)26(34)31-13-22-15(2)7-23(27)32-16(22)3/h4-8,10-12H,9,13H2,1-3H3,(H2,27,32)(H2,28,33)(H,31,34)
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n/an/a<100n/an/an/an/an/an/a



LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...


US Patent US10308637 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM283625
PNG
(N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)- 2-((...)
Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1ccnc(Cc2cc(-c3nnn[nH]3)c3ncc(Cl)cc3c2)c1
Show InChI InChI=1S/C25H22ClN9O/c1-13-5-22(27)31-14(2)21(13)12-30-25(36)16-3-4-28-19(10-16)7-15-6-17-9-18(26)11-29-23(17)20(8-15)24-32-34-35-33-24/h3-6,8-11H,7,12H2,1-2H3,(H2,27,31)(H,30,36)(H,32,33,34,35)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...


US Patent US10308637 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM283628
PNG
(N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)- 2-((...)
Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1ccnc(c1)C(O)c1ccc2ncc(Cl)cc2c1
Show InChI InChI=1/C24H22ClN5O2/c1-13-7-22(26)30-14(2)19(13)12-29-24(32)16-5-6-27-21(10-16)23(31)15-3-4-20-17(8-15)9-18(25)11-28-20/h3-11,23,31H,12H2,1-2H3,(H2,26,30)(H,29,32)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...


US Patent US10308637 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM283629
PNG
(2[Amino-(3-chloro-quinolin-6-yl)-methyl]-N- (6-ami...)
Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1ccnc(c1)C(N)c1ccc2ncc(Cl)cc2c1
Show InChI InChI=1/C24H23ClN6O/c1-13-7-22(26)31-14(2)19(13)12-30-24(32)16-5-6-28-21(10-16)23(27)15-3-4-20-17(8-15)9-18(25)11-29-20/h3-11,23H,12,27H2,1-2H3,(H2,26,31)(H,30,32)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...


US Patent US10308637 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM283631
PNG
(N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)- 2-((...)
Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1ccnc(Cc2ccc3ncc(CC(F)F)cc3c2)c1
Show InChI InChI=1S/C26H25F2N5O/c1-15-7-25(29)33-16(2)22(15)14-32-26(34)19-5-6-30-21(12-19)10-17-3-4-23-20(8-17)9-18(13-31-23)11-24(27)28/h3-9,12-13,24H,10-11,14H2,1-2H3,(H2,29,33)(H,32,34)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...


US Patent US10308637 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM283632
PNG
(N-((6-amino-2-methylpyridin-3-yl)methyl)-2- ((3-(2...)
Show SMILES Cc1nc(N)ccc1CNC(=O)c1ccnc(Cc2ccc3ncc(CC(F)F)cc3c2)c1
Show InChI InChI=1S/C25H23F2N5O/c1-15-19(3-5-24(28)32-15)14-31-25(33)18-6-7-29-21(12-18)10-16-2-4-22-20(8-16)9-17(13-30-22)11-23(26)27/h2-9,12-13,23H,10-11,14H2,1H3,(H2,28,32)(H,31,33)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...


US Patent US10308637 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM283633
PNG
(N-((3-chloro-6-fluoro-1H-indol-5-yl)methyl)-2- ((3...)
Show SMILES CCc1cnc2ccc(Cc3cc(ccn3)C(=O)NCc3cc4c(Cl)c[nH]c4cc3F)cc2c1
Show InChI InChI=1S/C27H22ClFN4O/c1-2-16-7-19-8-17(3-4-25(19)31-13-16)9-21-10-18(5-6-30-21)27(34)33-14-20-11-22-23(28)15-32-26(22)12-24(20)29/h3-8,10-13,15,32H,2,9,14H2,1H3,(H,33,34)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...


US Patent US10308637 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM283634
PNG
(N-((3-chloro-1H-pyrrolo[2,3-b]pyridin-5- yl)methyl...)
Show SMILES CCc1cnc2ccc(Cc3cc(ccn3)C(=O)NCc3cnc4[nH]cc(Cl)c4c3)cc2c1
Show InChI InChI=1S/C26H22ClN5O/c1-2-16-7-20-8-17(3-4-24(20)29-12-16)9-21-11-19(5-6-28-21)26(33)32-14-18-10-22-23(27)15-31-25(22)30-13-18/h3-8,10-13,15H,2,9,14H2,1H3,(H,30,31)(H,32,33)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...


US Patent US10308637 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM283635
PNG
(N-((3-chloro-4-fluoro-1H-indol-5-yl)methyl)-2- ((3...)
Show SMILES CCc1cnc2ccc(Cc3cc(ccn3)C(=O)NCc3ccc4[nH]cc(Cl)c4c3F)cc2c1
Show InChI InChI=1S/C27H22ClFN4O/c1-2-16-9-20-10-17(3-5-23(20)31-13-16)11-21-12-18(7-8-30-21)27(34)33-14-19-4-6-24-25(26(19)29)22(28)15-32-24/h3-10,12-13,15,32H,2,11,14H2,1H3,(H,33,34)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...


US Patent US10308637 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM283636
PNG
(N-((1-aminoisoquinolin-6-yl)methyl)-2-((3- ethylqu...)
Show SMILES CCc1cnc2ccc(Cc3cc(ccn3)C(=O)NCc3ccc4c(N)nccc4c3)cc2c1
Show InChI InChI=1S/C28H25N5O/c1-2-18-11-23-12-19(4-6-26(23)32-16-18)14-24-15-22(8-9-30-24)28(34)33-17-20-3-5-25-21(13-20)7-10-31-27(25)29/h3-13,15-16H,2,14,17H2,1H3,(H2,29,31)(H,33,34)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...


US Patent US10308637 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM283637
PNG
(N-((5-chloro-1H-indazol-3-yl)methyl)-2-((3- ethylq...)
Show SMILES CCc1cnc2ccc(Cc3cc(ccn3)C(=O)NCc3n[nH]c4ccc(Cl)cc34)cc2c1
Show InChI InChI=1S/C26H22ClN5O/c1-2-16-9-19-10-17(3-5-23(19)29-14-16)11-21-12-18(7-8-28-21)26(33)30-15-25-22-13-20(27)4-6-24(22)31-32-25/h3-10,12-14H,2,11,15H2,1H3,(H,30,33)(H,31,32)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...


US Patent US10308637 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM283638
PNG
(N-((6-amino-2-methylpyridin-3-yl)methyl)-2- ((3-et...)
Show SMILES CCc1cnc2ccc(Cc3cc(ccn3)C(=O)NCc3ccc(N)nc3C)cc2c1
Show InChI InChI=1S/C25H25N5O/c1-3-17-10-21-11-18(4-6-23(21)28-14-17)12-22-13-19(8-9-27-22)25(31)29-15-20-5-7-24(26)30-16(20)2/h4-11,13-14H,3,12,15H2,1-2H3,(H2,26,30)(H,29,31)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...


US Patent US10308637 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM283639
PNG
(N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)- 2-((...)
Show SMILES CCc1cnc2ccc(Cc3cc(ccn3)C(=O)NCc3c(C)cc(N)nc3C)cc2c1
Show InChI InChI=1S/C26H27N5O/c1-4-18-10-21-11-19(5-6-24(21)29-14-18)12-22-13-20(7-8-28-22)26(32)30-15-23-16(2)9-25(27)31-17(23)3/h5-11,13-14H,4,12,15H2,1-3H3,(H2,27,31)(H,30,32)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...


US Patent US10308637 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM283640
PNG
(N-((3-chloro-6-fluoro-1H-indol-5-yl)methyl)-2- ((3...)
Show SMILES Cc1cnc2c(cc(Cc3cc(ccn3)C(=O)NCc3cc4c(Cl)c[nH]c4cc3F)cc2c1)S(N)(=O)=O
Show InChI InChI=1S/C26H21ClFN5O3S/c1-14-4-17-5-15(7-24(37(29,35)36)25(17)32-11-14)6-19-8-16(2-3-30-19)26(34)33-12-18-9-20-21(27)13-31-23(20)10-22(18)28/h2-5,7-11,13,31H,6,12H2,1H3,(H,33,34)(H2,29,35,36)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...


US Patent US10308637 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM283641
PNG
(N-((5-chloro-1H-indazol-3-yl)methyl)-2-((3- methyl...)
Show SMILES Cc1cnc2c(cc(Cc3cc(ccn3)C(=O)NCc3n[nH]c4ccc(Cl)cc34)cc2c1)S(N)(=O)=O
Show InChI InChI=1S/C25H21ClN6O3S/c1-14-6-17-7-15(9-23(36(27,34)35)24(17)29-12-14)8-19-10-16(4-5-28-19)25(33)30-13-22-20-11-18(26)2-3-21(20)31-32-22/h2-7,9-12H,8,13H2,1H3,(H,30,33)(H,31,32)(H2,27,34,35)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...


US Patent US10308637 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM283642
PNG
(N-((1-aminoisoquinolin-6-yl)methyl)-2-((3- methyl-...)
Show SMILES Cc1cnc2c(cc(Cc3cc(ccn3)C(=O)NCc3ccc4c(N)nccc4c3)cc2c1)S(N)(=O)=O
Show InChI InChI=1S/C27H24N6O3S/c1-16-8-21-10-18(12-24(37(29,35)36)25(21)32-14-16)11-22-13-20(5-6-30-22)27(34)33-15-17-2-3-23-19(9-17)4-7-31-26(23)28/h2-10,12-14H,11,15H2,1H3,(H2,28,31)(H,33,34)(H2,29,35,36)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...


US Patent US10308637 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM283643
PNG
(N-((3-chloro-4-fluoro-1H-indol-5-yl)methyl)-2- ((3...)
Show SMILES Cc1cnc2c(cc(Cc3cc(ccn3)C(=O)NCc3ccc4[nH]cc(Cl)c4c3F)cc2c1)S(N)(=O)=O
Show InChI InChI=1S/C26H21ClFN5O3S/c1-14-6-18-7-15(9-22(37(29,35)36)25(18)32-11-14)8-19-10-16(4-5-30-19)26(34)33-12-17-2-3-21-23(24(17)28)20(27)13-31-21/h2-7,9-11,13,31H,8,12H2,1H3,(H,33,34)(H2,29,35,36)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...


US Patent US10308637 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM283644
PNG
(N-((3-chloro-1H-pyrrolo[2,3-b]pyridin-5- yl)methyl...)
Show SMILES Cc1cnc2c(cc(Cc3cc(ccn3)C(=O)NCc3cnc4[nH]cc(Cl)c4c3)cc2c1)S(N)(=O)=O
Show InChI InChI=1S/C25H21ClN6O3S/c1-14-4-18-5-15(8-22(36(27,34)35)23(18)29-10-14)6-19-9-17(2-3-28-19)25(33)32-12-16-7-20-21(26)13-31-24(20)30-11-16/h2-5,7-11,13H,6,12H2,1H3,(H,30,31)(H,32,33)(H2,27,34,35)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...


US Patent US10308637 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM283650
PNG
(N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)- 2-((...)
Show SMILES COC(c1ccc2ncc(Cl)cc2c1)c1cc(ccn1)C(=O)NCc1c(C)cc(N)nc1C
Show InChI InChI=1/C25H24ClN5O2/c1-14-8-23(27)31-15(2)20(14)13-30-25(32)17-6-7-28-22(11-17)24(33-3)16-4-5-21-18(9-16)10-19(26)12-29-21/h4-12,24H,13H2,1-3H3,(H2,27,31)(H,30,32)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...


US Patent US10308637 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM283661
PNG
(N-((1-aminoisoquinolin-6-yl)methyl)-2-((3- (pyrrol...)
Show SMILES Nc1nccc2cc(CNC(=O)c3ccnc(Cc4ccc5ncc(cc5c4)N4CCCC4)c3)ccc12
Show InChI InChI=1S/C30H28N6O/c31-29-27-5-3-21(14-22(27)7-10-33-29)18-35-30(37)23-8-9-32-25(16-23)15-20-4-6-28-24(13-20)17-26(19-34-28)36-11-1-2-12-36/h3-10,13-14,16-17,19H,1-2,11-12,15,18H2,(H2,31,33)(H,35,37)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...


US Patent US10308637 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM283667
PNG
(N-((3-chloro-6-fluoro-1H-indol-5-yl)methyl)-2- ((8...)
Show SMILES Cc1cnc2c(cc(Cc3cc(ccn3)C(=O)NCc3cc4c(Cl)c[nH]c4cc3F)cc2c1)C(C)(C)O
Show InChI InChI=1S/C29H26ClFN4O2/c1-16-6-19-7-17(9-23(29(2,3)37)27(19)34-13-16)8-21-10-18(4-5-32-21)28(36)35-14-20-11-22-24(30)15-33-26(22)12-25(20)31/h4-7,9-13,15,33,37H,8,14H2,1-3H3,(H,35,36)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...


US Patent US10308637 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM283668
PNG
(N-((3-chloro-4-fluoro-1H-indol-5-yl)methyl)-2- ((8...)
Show SMILES Cc1cnc2c(cc(Cc3cc(ccn3)C(=O)NCc3ccc4[nH]cc(Cl)c4c3F)cc2c1)C(C)(C)O
Show InChI InChI=1S/C29H26ClFN4O2/c1-16-8-20-9-17(11-22(29(2,3)37)27(20)34-13-16)10-21-12-18(6-7-32-21)28(36)35-14-19-4-5-24-25(26(19)31)23(30)15-33-24/h4-9,11-13,15,33,37H,10,14H2,1-3H3,(H,35,36)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...


US Patent US10308637 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM283669
PNG
(N-((3-chloro-1H-pyrrolo[2,3-b]pyridin-5- yl)methyl...)
Show SMILES Cc1cnc2c(cc(Cc3cc(ccn3)C(=O)NCc3cnc4[nH]cc(Cl)c4c3)cc2c1)C(C)(C)O
Show InChI InChI=1S/C28H26ClN5O2/c1-16-6-20-7-17(10-23(28(2,3)36)25(20)31-12-16)8-21-11-19(4-5-30-21)27(35)34-14-18-9-22-24(29)15-33-26(22)32-13-18/h4-7,9-13,15,36H,8,14H2,1-3H3,(H,32,33)(H,34,35)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...


US Patent US10308637 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM283670
PNG
(N-((5-chloro-1H-indazol-3-yl)methyl)-2-((8-(2- hyd...)
Show SMILES Cc1cnc2c(cc(Cc3cc(ccn3)C(=O)NCc3n[nH]c4ccc(Cl)cc34)cc2c1)C(C)(C)O
Show InChI InChI=1S/C28H26ClN5O2/c1-16-8-19-9-17(11-23(28(2,3)36)26(19)31-14-16)10-21-12-18(6-7-30-21)27(35)32-15-25-22-13-20(29)4-5-24(22)33-34-25/h4-9,11-14,36H,10,15H2,1-3H3,(H,32,35)(H,33,34)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...


US Patent US10308637 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM283671
PNG
(N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)- 2-((...)
Show SMILES Cc1cnc2c(cc(Cc3cc(ccn3)C(=O)NCc3c(C)cc(N)nc3C)cc2c1)C(C)(C)O
Show InChI InChI=1S/C28H31N5O2/c1-16-8-21-10-19(12-24(28(4,5)35)26(21)31-14-16)11-22-13-20(6-7-30-22)27(34)32-15-23-17(2)9-25(29)33-18(23)3/h6-10,12-14,35H,11,15H2,1-5H3,(H2,29,33)(H,32,34)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...


US Patent US10308637 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM283672
PNG
(N-((1-aminoisoquinolin-6-yl)methyl)-2-((8-2- hydro...)
Show SMILES Cc1cnc2c(cc(Cc3cc(ccn3)C(=O)NCc3ccc4c(N)nccc4c3)cc2c1)C(C)(C)O
Show InChI InChI=1S/C30H29N5O2/c1-18-10-23-12-20(14-26(30(2,3)37)27(23)34-16-18)13-24-15-22(7-8-32-24)29(36)35-17-19-4-5-25-21(11-19)6-9-33-28(25)31/h4-12,14-16,37H,13,17H2,1-3H3,(H2,31,33)(H,35,36)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...


US Patent US10308637 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM283673
PNG
(2-((3-(azetidin-1-yl)quinolin-6-yl)methyl)-N-((3-c...)
Show SMILES Fc1cc2[nH]cc(Cl)c2cc1CNC(=O)c1ccnc(Cc2ccc3ncc(cc3c2)N2CCC2)c1
Show InChI InChI=1S/C28H23ClFN5O/c29-24-16-33-27-13-25(30)20(12-23(24)27)14-34-28(36)18-4-5-31-21(10-18)9-17-2-3-26-19(8-17)11-22(15-32-26)35-6-1-7-35/h2-5,8,10-13,15-16,33H,1,6-7,9,14H2,(H,34,36)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...


US Patent US10308637 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM283351
PNG
(N-((1-aminoisoquinolin-6-yl)methyl)-2-((2- cyanoqu...)
Show SMILES Nc1nccc2cc(CNC(=O)c3ccnc(Cc4ccc5nc(ccc5c4)C#N)c3)ccc12
Show InChI InChI=1S/C27H20N6O/c28-15-22-4-3-20-11-17(2-6-25(20)33-22)13-23-14-21(8-9-30-23)27(34)32-16-18-1-5-24-19(12-18)7-10-31-26(24)29/h1-12,14H,13,16H2,(H2,29,31)(H,32,34)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...


US Patent US10308637 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM283353
PNG
(N-((3-chloro-6-fluoro-1H-indol-5-yl)methyl)-2- ((3...)
Show SMILES Fc1cc2[nH]cc(Cl)c2cc1CNC(=O)c1ccnc(Cc2ccc3ncc(cc3c2)C#N)c1
Show InChI InChI=1S/C26H17ClFN5O/c27-22-14-32-25-10-23(28)19(9-21(22)25)13-33-26(34)17-3-4-30-20(8-17)7-15-1-2-24-18(5-15)6-16(11-29)12-31-24/h1-6,8-10,12,14,32H,7,13H2,(H,33,34)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...


US Patent US10308637 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM283354
PNG
(N-((1-aminoisoquinolin-6-yl)methyl)-2-((3- cyanoqu...)
Show SMILES Nc1nccc2cc(CNC(=O)c3ccnc(Cc4ccc5ncc(cc5c4)C#N)c3)ccc12
Show InChI InChI=1S/C27H20N6O/c28-14-19-11-22-9-17(2-4-25(22)32-16-19)12-23-13-21(6-7-30-23)27(34)33-15-18-1-3-24-20(10-18)5-8-31-26(24)29/h1-11,13,16H,12,15H2,(H2,29,31)(H,33,34)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...


US Patent US10308637 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM283355
PNG
(N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)- 2-((...)
Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1ccnc(Cc2ccc3ncc(cc3c2)C#N)c1
Show InChI InChI=1S/C25H22N6O/c1-15-7-24(27)31-16(2)22(15)14-30-25(32)19-5-6-28-21(11-19)10-17-3-4-23-20(8-17)9-18(12-26)13-29-23/h3-9,11,13H,10,14H2,1-2H3,(H2,27,31)(H,30,32)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...


US Patent US10308637 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM283360
PNG
(N-((3-chloro-6-fluoro-1H-indol-5-yl)methyl)-2- ((6...)
Show SMILES CS(=O)(=O)c1ccc2ncc(Cc3cc(ccn3)C(=O)NCc3cc4c(Cl)c[nH]c4cc3F)cc2c1
Show InChI InChI=1S/C26H20ClFN4O3S/c1-36(34,35)20-2-3-24-17(9-20)6-15(12-30-24)7-19-8-16(4-5-29-19)26(33)32-13-18-10-21-22(27)14-31-25(21)11-23(18)28/h2-6,8-12,14,31H,7,13H2,1H3,(H,32,33)
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LIFESCI PHARMACEUTICALS, INC.

US Patent


Assay Description
A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...


US Patent US10308637 (2019)

More data for this
Ligand-Target Pair
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