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Compile Data Set for Download or QSAR

Found 157 hits Enz. Inhib. hit(s) with Target = 'Mixed lineage kinase 7'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mixed lineage kinase 7


(Homo sapiens)
BDBM50096279
PNG
(CHEMBL3577124)
Show SMILES CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)NCCC(C)(C)C)c(F)cc1C
Show InChI InChI=1S/C18H13N3O5/c22-14(23)5-4-10-8-21-13-7-12-9(6-15(24)25)2-1-3-11(12)16(13)20-18(26)17(21)19-10/h1-5,8H,6-7H2,(H,20,26)(H,22,23)(H,24,25)/b5-4+
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n/an/a 39n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Competitive binding affinity to ZAK in human A375 cells after 15 mins in presence of ATP analogue


Citation and Details
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens)
BDBM50184490
PNG
(3-[6-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]...)
Show SMILES OCCCn1cnc2ccc(cc12)-c1c2CCCn2nc1-c1ccccn1
Show InChI InChI=1S/C21H21N5O/c27-12-4-10-25-14-23-16-8-7-15(13-19(16)25)20-18-6-3-11-26(18)24-21(20)17-5-1-2-9-22-17/h1-2,5,7-9,13-14,27H,3-4,6,10-12H2
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n/an/a 708n/an/an/an/an/an/a



Lilly Research Laboratory

Curated by ChEMBL


Assay Description
Inhibition of MLK7


Citation and Details
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens)
BDBM50184486
PNG
(1-methyl-6-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[...)
Show SMILES Cn1cnc2ccc(cc12)-c1c2CCCn2nc1-c1ccccn1
Show InChI InChI=1S/C19H17N5/c1-23-12-21-14-8-7-13(11-17(14)23)18-16-6-4-10-24(16)22-19(18)15-5-2-3-9-20-15/h2-3,5,7-9,11-12H,4,6,10H2,1H3
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n/an/a 1.31E+3n/an/an/an/an/an/a



Lilly Research Laboratory

Curated by ChEMBL


Assay Description
Inhibition of MLK7


Citation and Details
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens)
BDBM21492
PNG
(4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...)
Show SMILES c1[nH]nc(c1-c1ccnc2ccccc12)-c1ccccn1
Show InChI InChI=1S/C17H12N4/c1-2-6-15-13(5-1)12(8-10-19-15)14-11-20-21-17(14)16-7-3-4-9-18-16/h1-11H,(H,20,21)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Lilly Research Laboratory

Curated by ChEMBL


Assay Description
Inhibition of MLK7


Citation and Details
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens)
BDBM50184483
PNG
(1-methyl-6-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4...)
Show SMILES Cc1cccc(n1)-c1nn2CCCc2c1-c1ccc2ncn(C)c2c1
Show InChI InChI=1S/C20H19N5/c1-13-5-3-6-16(22-13)20-19(17-7-4-10-25(17)23-20)14-8-9-15-18(11-14)24(2)12-21-15/h3,5-6,8-9,11-12H,4,7,10H2,1-2H3
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n/an/a 2.34E+3n/an/an/an/an/an/a



Lilly Research Laboratory

Curated by ChEMBL


Assay Description
Inhibition of MLK7


Citation and Details
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens)
BDBM50184489
PNG
(3-(6-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrr...)
Show SMILES Cc1cccc(n1)-c1nn2CCCc2c1-c1ccc2ncn(CCCO)c2c1
Show InChI InChI=1S/C22H23N5O/c1-15-5-2-6-18(24-15)22-21(19-7-3-11-27(19)25-22)16-8-9-17-20(13-16)26(14-23-17)10-4-12-28/h2,5-6,8-9,13-14,28H,3-4,7,10-12H2,1H3
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n/an/a 2.81E+3n/an/an/an/an/an/a



Lilly Research Laboratory

Curated by ChEMBL


Assay Description
Inhibition of MLK7


Citation and Details
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens)
BDBM50184491
PNG
(6-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]p...)
Show SMILES C(CN1CCCC1)Cn1cnc2ccc(cc12)-c1c2CCCn2nc1-c1ccccn1
Show InChI InChI=1S/C25H28N6/c1-2-11-26-21(7-1)25-24(22-8-5-16-31(22)28-25)19-9-10-20-23(17-19)30(18-27-20)15-6-14-29-12-3-4-13-29/h1-2,7,9-11,17-18H,3-6,8,12-16H2
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n/an/a 4.88E+3n/an/an/an/an/an/a



Lilly Research Laboratory

Curated by ChEMBL


Assay Description
Inhibition of MLK7


Citation and Details
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens)
BDBM50184487
PNG
(4-(3-(6-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-p...)
Show SMILES Cc1cccc(n1)-c1nn2CCCc2c1-c1ccc2ncn(CCCN3CCOCC3)c2c1
Show InChI InChI=1S/C26H30N6O/c1-19-5-2-6-22(28-19)26-25(23-7-3-12-32(23)29-26)20-8-9-21-24(17-20)31(18-27-21)11-4-10-30-13-15-33-16-14-30/h2,5-6,8-9,17-18H,3-4,7,10-16H2,1H3
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n/an/a 8.48E+3n/an/an/an/an/an/a



Lilly Research Laboratory

Curated by ChEMBL


Assay Description
Inhibition of MLK7


Citation and Details
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens)
BDBM50401152
PNG
(CHEMBL2205766)
Show SMILES CC(C)(C)NS(=O)(=O)c1cncc(c1)-c1ccn2nc(N)nc2c1
Show InChI InChI=1S/C15H18N6O2S/c1-15(2,3)20-24(22,23)12-6-11(8-17-9-12)10-4-5-21-13(7-10)18-14(16)19-21/h4-9,20H,1-3H3,(H2,16,19)
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n/an/a<1.00E+4n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of ZAK


Citation and Details
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens)
BDBM50150698
PNG
(3-(imidazo[1,2-a]pyridin-3-yl)-4-(2-(morpholine-4-...)
Show SMILES O=C(N1CCOCC1)N1CCn2cc(C3=C(C(=O)NC3=O)c3cnc4ccccn34)c3cccc(C1)c23
Show InChI InChI=1S/C27H24N6O4/c34-25-22(23(26(35)29-25)20-14-28-21-6-1-2-7-33(20)21)19-16-31-8-9-32(27(36)30-10-12-37-13-11-30)15-17-4-3-5-18(19)24(17)31/h1-7,14,16H,8-13,15H2,(H,29,34,35)
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n/an/a 1.34E+4n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human MLK7


Citation and Details
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens)
BDBM50184480
PNG
(CHEMBL202730 | dimethyl-{3-[6-(2-pyridin-2-yl-5,6-...)
Show SMILES CN(C)CCCn1cnc2ccc(cc12)-c1c2CCCn2nc1-c1ccccn1
Show InChI InChI=1S/C23H26N6/c1-27(2)12-6-13-28-16-25-18-10-9-17(15-21(18)28)22-20-8-5-14-29(20)26-23(22)19-7-3-4-11-24-19/h3-4,7,9-11,15-16H,5-6,8,12-14H2,1-2H3
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n/an/a 1.59E+4n/an/an/an/an/an/a



Lilly Research Laboratory

Curated by ChEMBL


Assay Description
Inhibition of MLK7


Citation and Details
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens)
BDBM50184488
PNG
(6-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrol...)
Show SMILES Cc1cccc(n1)-c1nn2CCCc2c1-c1ccc2nc[nH]c2c1
Show InChI InChI=1S/C19H17N5/c1-12-4-2-5-15(22-12)19-18(17-6-3-9-24(17)23-19)13-7-8-14-16(10-13)21-11-20-14/h2,4-5,7-8,10-11H,3,6,9H2,1H3,(H,20,21)
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n/an/a 1.59E+4n/an/an/an/an/an/a



Lilly Research Laboratory

Curated by ChEMBL


Assay Description
Inhibition of MLK7


Citation and Details
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens)
BDBM50184481
PNG
(1-methyl-5-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[...)
Show SMILES Cn1ccc2cc(ccc12)-c1c2CCCn2nc1-c1ccccn1
Show InChI InChI=1S/C20H18N4/c1-23-12-9-14-13-15(7-8-17(14)23)19-18-6-4-11-24(18)22-20(19)16-5-2-3-10-21-16/h2-3,5,7-10,12-13H,4,6,11H2,1H3
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n/an/a 1.66E+4n/an/an/an/an/an/a



Lilly Research Laboratory

Curated by ChEMBL


Assay Description
Inhibition of MLK7


Citation and Details
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens)
BDBM50184497
PNG
(6-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrol...)
Show SMILES Cc1cccc(n1)-c1nn2CCCc2c1-c1ccc2ncn(CCCN3CCCC3)c2c1
Show InChI InChI=1S/C26H30N6/c1-19-7-4-8-22(28-19)26-25(23-9-5-16-32(23)29-26)20-10-11-21-24(17-20)31(18-27-21)15-6-14-30-12-2-3-13-30/h4,7-8,10-11,17-18H,2-3,5-6,9,12-16H2,1H3
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n/an/a>2.00E+4n/an/an/an/an/an/a



Lilly Research Laboratory

Curated by ChEMBL


Assay Description
Inhibition of MLK7


Citation and Details
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens)
BDBM50184498
PNG
(5-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyr...)
Show SMILES C1Cc2c(c(nn2C1)-c1ccccn1)-c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C19H16N4/c1-2-9-20-16(4-1)19-18(17-5-3-11-23(17)22-19)14-6-7-15-13(12-14)8-10-21-15/h1-2,4,6-10,12,21H,3,5,11H2
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n/an/a>2.00E+4n/an/an/an/an/an/a



Lilly Research Laboratory

Curated by ChEMBL


Assay Description
Inhibition of MLK7


Citation and Details
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens)
BDBM50184493
PNG
(CHEMBL203791 | N,N-diethyl-3-(6-(2-(6-methylpyridi...)
Show SMILES CCN(CC)CCCn1cnc2ccc(cc12)-c1c2CCCn2nc1-c1cccc(C)n1
Show InChI InChI=1S/C26H32N6/c1-4-30(5-2)14-8-15-31-18-27-21-13-12-20(17-24(21)31)25-23-11-7-16-32(23)29-26(25)22-10-6-9-19(3)28-22/h6,9-10,12-13,17-18H,4-5,7-8,11,14-16H2,1-3H3
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n/an/a>2.00E+4n/an/an/an/an/an/a



Lilly Research Laboratory

Curated by ChEMBL


Assay Description
Inhibition of MLK7


Citation and Details
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens)
BDBM50184496
PNG
(CHEMBL441176 | dimethyl-(3-{6-[2-(6-methyl-pyridin...)
Show SMILES CN(C)CCCn1cnc2ccc(cc12)-c1c2CCCn2nc1-c1cccc(C)n1
Show InChI InChI=1S/C24H28N6/c1-17-7-4-8-20(26-17)24-23(21-9-5-14-30(21)27-24)18-10-11-19-22(15-18)29(16-25-19)13-6-12-28(2)3/h4,7-8,10-11,15-16H,5-6,9,12-14H2,1-3H3
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Lilly Research Laboratory

Curated by ChEMBL


Assay Description
Inhibition of MLK7


Citation and Details
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens)
BDBM50184494
PNG
(6-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrol...)
Show SMILES Cc1cccc(n1)-c1nn2CCCc2c1-c1ccc2ncn(CCCN3CCCCC3)c2c1
Show InChI InChI=1S/C27H32N6/c1-20-8-5-9-23(29-20)27-26(24-10-6-17-33(24)30-27)21-11-12-22-25(18-21)32(19-28-22)16-7-15-31-13-3-2-4-14-31/h5,8-9,11-12,18-19H,2-4,6-7,10,13-17H2,1H3
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Lilly Research Laboratory

Curated by ChEMBL


Assay Description
Inhibition of MLK7


Citation and Details
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens)
BDBM50184492
PNG
(5-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]p...)
Show SMILES C1Cc2c(c(nn2C1)-c1ccccn1)-c1ccc2nc[nH]c2c1
Show InChI InChI=1S/C18H15N5/c1-2-8-19-14(4-1)18-17(16-5-3-9-23(16)22-18)12-6-7-13-15(10-12)21-11-20-13/h1-2,4,6-8,10-11H,3,5,9H2,(H,20,21)
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n/an/a>2.00E+4n/an/an/an/an/an/a



Lilly Research Laboratory

Curated by ChEMBL


Assay Description
Inhibition of MLK7


Citation and Details
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens)
BDBM50184484
PNG
(5-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyr...)
Show SMILES C(COC1CCCCO1)Cn1cnc2cc(ccc12)-c1c2CCCn2nc1-c1ccccn1
Show InChI InChI=1S/C26H29N5O2/c1-3-12-27-20(7-1)26-25(23-8-5-14-31(23)29-26)19-10-11-22-21(17-19)28-18-30(22)13-6-16-33-24-9-2-4-15-32-24/h1,3,7,10-12,17-18,24H,2,4-6,8-9,13-16H2
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Lilly Research Laboratory

Curated by ChEMBL


Assay Description
Inhibition of MLK7


Citation and Details
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens)
BDBM50184495
PNG
(1-methyl-5-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-...)
Show SMILES Cc1cccc(n1)-c1nn2CCCc2c1-c1ccc2n(C)ccc2c1
Show InChI InChI=1S/C21H20N4/c1-14-5-3-6-17(22-14)21-20(19-7-4-11-25(19)23-21)16-8-9-18-15(13-16)10-12-24(18)2/h3,5-6,8-10,12-13H,4,7,11H2,1-2H3
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n/an/a>2.00E+4n/an/an/an/an/an/a



Lilly Research Laboratory

Curated by ChEMBL


Assay Description
Inhibition of MLK7


Citation and Details
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens)
BDBM50184485
PNG
(5-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo...)
Show SMILES Cc1cccc(n1)-c1nn2CCCc2c1-c1ccc2n(CCCOC3CCCCO3)cnc2c1
Show InChI InChI=1S/C27H31N5O2/c1-19-7-4-8-21(29-19)27-26(24-9-5-14-32(24)30-27)20-11-12-23-22(17-20)28-18-31(23)13-6-16-34-25-10-2-3-15-33-25/h4,7-8,11-12,17-18,25H,2-3,5-6,9-10,13-16H2,1H3
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Lilly Research Laboratory

Curated by ChEMBL


Assay Description
Inhibition of MLK7


Citation and Details
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens)
BDBM50150700
PNG
(7-(4-Imidazo[1,2-a]pyridin-3-yl-2,5-dioxo-2,5-dihy...)
Show SMILES CC(C)OC(=O)N1CCn2cc(C3=C(C(=O)NC3=O)c3cnc4ccccn34)c3cccc(C1)c23
Show InChI InChI=1S/C26H23N5O4/c1-15(2)35-26(34)30-11-10-29-14-18(17-7-5-6-16(13-30)23(17)29)21-22(25(33)28-24(21)32)19-12-27-20-8-3-4-9-31(19)20/h3-9,12,14-15H,10-11,13H2,1-2H3,(H,28,32,33)
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n/an/a>2.00E+4n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human MLK7


Citation and Details
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens)
BDBM50150702
PNG
(3-Imidazo[1,2-a]pyridin-3-yl-4-[2-(piperidine-1-ca...)
Show SMILES O=C(N1CCCCC1)N1CCn2cc(C3=C(C(=O)NC3=O)c3cnc4ccccn34)c3cccc(C1)c23
Show InChI InChI=1S/C28H26N6O3/c35-26-23(24(27(36)30-26)21-15-29-22-9-2-5-12-34(21)22)20-17-32-13-14-33(28(37)31-10-3-1-4-11-31)16-18-7-6-8-19(20)25(18)32/h2,5-9,12,15,17H,1,3-4,10-11,13-14,16H2,(H,30,35,36)
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n/an/a>2.00E+4n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human MLK7


Citation and Details
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens)
BDBM50150699
PNG
(3-(9-fluoro-2-(piperidine-1-carbonyl)-1,2,3,4-tetr...)
Show SMILES Fc1cc2CN(CCn3cc(C4=C(C(=O)NC4=O)c4cnc5ccccn45)c(c1)c23)C(=O)N1CCCCC1
Show InChI InChI=1S/C28H25FN6O3/c29-18-12-17-15-34(28(38)32-7-3-1-4-8-32)11-10-33-16-20(19(13-18)25(17)33)23-24(27(37)31-26(23)36)21-14-30-22-6-2-5-9-35(21)22/h2,5-6,9,12-14,16H,1,3-4,7-8,10-11,15H2,(H,31,36,37)
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human MLK7


Citation and Details
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens)
BDBM50150701
PNG
(7-(4-(H-imidazo[1,2-a]pyridin-3-yl)-2,5-dioxo-2,5-...)
Show SMILES CN(C)C(=O)N1CCn2cc(C3=C(C(=O)NC3=O)c3cnc4ccccn34)c3cccc(C1)c23
Show InChI InChI=1S/C25H22N6O3/c1-28(2)25(34)30-11-10-29-14-17(16-7-5-6-15(13-30)22(16)29)20-21(24(33)27-23(20)32)18-12-26-19-8-3-4-9-31(18)19/h3-9,12,14H,10-11,13H2,1-2H3,(H,27,32,33)
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n/an/a>2.00E+4n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human MLK7


Citation and Details
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens)
BDBM50184482
PNG
(1-methyl-5-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[...)
Show SMILES Cn1cnc2cc(ccc12)-c1c2CCCn2nc1-c1ccccn1
Show InChI InChI=1S/C19H17N5/c1-23-12-21-15-11-13(7-8-16(15)23)18-17-6-4-10-24(17)22-19(18)14-5-2-3-9-20-14/h2-3,5,7-9,11-12H,4,6,10H2,1H3
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Lilly Research Laboratory

Curated by ChEMBL


Assay Description
Inhibition of MLK7


Citation and Details
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens)
BDBM50224883
PNG
(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Show SMILES Clc1cc2NC(=O)Nc3cnc(C#N)c(OCCCCOc2cc1NCc1cncs1)n3
Show InChI InChI=1S/C20H18ClN7O3S/c21-13-5-15-17(6-14(13)24-9-12-8-23-11-32-12)30-3-1-2-4-31-19-16(7-22)25-10-18(27-19)28-20(29)26-15/h5-6,8,10-11,24H,1-4,9H2,(H2,26,27,28,29)
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>8.57E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ZAK


Citation and Details
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens)
BDBM50326053
PNG
(CHEMBL608533 | NA | PKC-412)
Show SMILES CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1
Show InChI InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m1/s1
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Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for ZAK kinase domain


Citation and Details
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens)
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for ZAK kinase domain


Citation and Details
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens)
BDBM4851
PNG
((4-chlorophenyl)-[4-(4-pyridylmethyl)phthalazin-1-...)
Show SMILES Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1
Show InChI InChI=1S/C20H15ClN4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14/h1-12H,13H2,(H,23,25)
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n/an/an/a 4.40E+3n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for ZAK kinase domain


Citation and Details
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens)
BDBM7533
PNG
((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)
Show SMILES CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1
Show InChI InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1
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n/an/an/a>1.00E+4n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for ZAK kinase domain


Citation and Details
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens)
BDBM13531
PNG
(4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridy...)
Show SMILES Oc1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24)
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n/an/an/a>1.00E+4n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for ZAK kinase domain


Citation and Details
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens)
BDBM13336
PNG
(4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-...)
Show SMILES CS(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25)
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n/an/an/a 4.40E+3n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for ZAK kinase domain


Citation and Details
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens)
BDBM50110208
PNG
(4-(4-(benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1...)
Show SMILES NC(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc2OCOc2c1)-c1ccccn1
Show InChI InChI=1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26)
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n/an/an/a>1.00E+4n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for ZAK kinase domain


Citation and Details
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens)
BDBM16673
PNG
(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1
Show InChI InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)
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n/an/an/a 6.30n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for ZAK kinase domain


Citation and Details
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens)
BDBM31095
PNG
(5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...)
Show SMILES Cc1[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1
Show InChI InChI=1S/C23H27FN4O4/c1-13-20(10-18-17-9-15(24)3-4-19(17)27-22(18)30)26-14(2)21(13)23(31)25-11-16(29)12-28-5-7-32-8-6-28/h3-4,9-10,16,26,29H,5-8,11-12H2,1-2H3,(H,25,31)(H,27,30)/b18-10-/t16-/m0/s1
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Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for ZAK kinase domain


Citation and Details
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens)
BDBM4814
PNG
(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Show SMILES CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C
Show InChI InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12-
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n/an/an/a>1.00E+4n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for ZAK kinase domain


Citation and Details
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens)
BDBM13534
PNG
(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Show SMILES CN1CCN(CC1)c1cc(Nc2cc(C)n[nH]2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1
Show InChI InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29)
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n/an/an/a 2.80E+3n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for ZAK kinase domain


Citation and Details
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens)
BDBM15244
PNG
(5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfa...)
Show SMILES Fc1ccc(Sc2ccc3c(-c4c(Cl)cccc4Cl)c(=O)ncn3n2)c(F)c1
Show InChI InChI=1S/C19H9Cl2F2N3OS/c20-11-2-1-3-12(21)17(11)18-14-5-7-16(25-26(14)9-24-19(18)27)28-15-6-4-10(22)8-13(15)23/h1-9H
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n/an/an/a>1.00E+4n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for ZAK kinase domain


Citation and Details
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens)
BDBM21
PNG
(6-[(4R,5S,6S,7R)-4,7-dibenzyl-3-(5-carboxypentyl)-...)
Show SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27)
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n/an/an/a 5.10E+3n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for ZAK kinase domain


Citation and Details
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens)
BDBM13535
PNG
(4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin...)
Show SMILES COc1cc2c(ncnc2cc1OCCCN1CCCCC1)N1CCN(CC1)C(=O)Nc1ccc(OC(C)C)cc1
Show InChI InChI=1S/C31H42N6O4/c1-23(2)41-25-10-8-24(9-11-25)34-31(38)37-17-15-36(16-18-37)30-26-20-28(39-3)29(21-27(26)32-22-33-30)40-19-7-14-35-12-5-4-6-13-35/h8-11,20-23H,4-7,12-19H2,1-3H3,(H,34,38)
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n/an/an/a>1.00E+4n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding affinity to ZAK


Citation and Details
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens)
BDBM50300690
PNG
(CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCN4CCOCC4)ccc32)no1
Show InChI InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36)
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n/an/an/a>1.00E+4n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding affinity to ZAK


Citation and Details
More data for this
Ligand-Target Pair
ZAK


(Homo sapiens)
BDBM31085
PNG
(1-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluorom...)
Show SMILES CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C26H30F3N7O2/c1-3-35-10-12-36(13-11-35)16-18-4-5-20(14-22(18)26(27,28)29)34-25(37)33-19-6-8-21(9-7-19)38-24-15-23(30-2)31-17-32-24/h4-9,14-15,17H,3,10-13,16H2,1-2H3,(H,30,31,32)(H2,33,34,37)
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n/an/an/a 2.30E+3n/an/an/an/an/a



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Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


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Ligand-Target Pair
ZAK


(Homo sapiens)
BDBM26300
PNG
(2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}qu...)
Show SMILES CCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)n[nH]3)ncnc2c1
Show InChI InChI=1S/C26H30FN7O3/c1-2-34(10-11-35)9-4-12-37-21-7-8-22-23(16-21)28-17-29-26(22)31-24-14-20(32-33-24)15-25(36)30-19-6-3-5-18(27)13-19/h3,5-8,13-14,16-17,35H,2,4,9-12,15H2,1H3,(H,30,36)(H2,28,29,31,32,33)
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n/an/an/a 1.70E+6n/an/an/an/an/a



Ambit Biosciences

Curated by PubChem BioAssay


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Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


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More data for this
Ligand-Target Pair
ZAK


(Homo sapiens)
BDBM13533
PNG
(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37)
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n/an/an/a 8.60E+5n/an/an/an/an/a



Ambit Biosciences

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Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


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Ligand-Target Pair
ZAK


(Homo sapiens)
BDBM31088
PNG
(1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-y...)
Show SMILES Cn1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)ccc12
Show InChI InChI=1S/C24H16F6N6O/c1-36-19-7-6-15(10-17(19)34-22(36)33-14-4-2-13(3-5-14)23(25,26)27)37-16-8-9-31-18(11-16)21-32-12-20(35-21)24(28,29)30/h2-12H,1H3,(H,32,35)(H,33,34)
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n/an/an/a 6.30E+4n/an/an/an/an/a



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Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


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More data for this
Ligand-Target Pair
ZAK


(Homo sapiens)
BDBM4779
PNG
(CHEMBL31965 | CHEMBL545315 | CI-1033 | N-{4-[(3-ch...)
Show SMILES Fc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(NC(=O)C=C)cc23)cc1Cl
Show InChI InChI=1S/C24H25ClFN5O3/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16/h2,4-5,12-15H,1,3,6-11H2,(H,30,32)(H,27,28,29)
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n/an/an/a 1.20E+6n/an/an/an/an/a



Ambit Biosciences

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Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


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More data for this
Ligand-Target Pair
ZAK


(Homo sapiens)
BDBM13216
PNG
(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Show SMILES Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1
Show InChI InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)
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n/an/an/a 4.50E+4n/an/an/an/an/a



Ambit Biosciences

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Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


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More data for this
Ligand-Target Pair
ZAK


(Homo sapiens)
BDBM31090
PNG
((E)-N-[4-(3-chloro-4-fluoro-anilino)-3-cyano-7-eth...)
Show SMILES CCOc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C
Show InChI InChI=1S/C24H23ClFN5O2/c1-4-33-22-12-20-17(11-21(22)30-23(32)6-5-9-31(2)3)24(15(13-27)14-28-20)29-16-7-8-19(26)18(25)10-16/h5-8,10-12,14H,4,9H2,1-3H3,(H,28,29)(H,30,32)/b6-5+
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n/an/an/a 1.20E+6n/an/an/an/an/a



Ambit Biosciences

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Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


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Ligand-Target Pair
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