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Found 178 hits Enz. Inhib. hit(s) with Target = 'Mixed lineage kinase 7'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mixed lineage kinase 7


(Homo sapiens (Human))
BDBM50268010
PNG
(CHEMBL4098896)
Show SMILES COc1n[nH]c2ncc(cc12)C#Cc1c(F)ccc(NS(=O)(=O)c2cccc(c2)C#N)c1F
Show InChI InChI=1S/C22H13F2N5O3S/c1-32-22-17-10-14(12-26-21(17)27-28-22)5-6-16-18(23)7-8-19(20(16)24)29-33(30,31)15-4-2-3-13(9-15)11-25/h2-4,7-10,12,29H,1H3,(H,26,27,28)
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n/an/a 3.30n/an/an/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged recombinant human full-length ZAK expressed in baculovirus infected Sf9 insect cells using MBP as substrate after...


J Med Chem 60: 5927-5932 (2017)

More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens (Human))
BDBM50268018
PNG
(CHEMBL4096439)
Show SMILES COc1n[nH]c2ncc(cc12)C#Cc1c(F)ccc(NS(=O)(=O)c2cccc(Cl)c2)c1F
Show InChI InChI=1S/C21H13ClF2N4O3S/c1-31-21-16-9-12(11-25-20(16)26-27-21)5-6-15-17(23)7-8-18(19(15)24)28-32(29,30)14-4-2-3-13(22)10-14/h2-4,7-11,28H,1H3,(H,25,26,27)
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n/an/a 4.20n/an/an/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged recombinant human full-length ZAK expressed in baculovirus infected Sf9 insect cells using MBP as substrate after...


J Med Chem 60: 5927-5932 (2017)

More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens (Human))
BDBM50268016
PNG
(CHEMBL4080860)
Show SMILES COc1n[nH]c2ncc(cc12)C#Cc1c(F)ccc(NS(=O)(=O)c2cccc(Br)c2)c1F
Show InChI InChI=1S/C21H13BrF2N4O3S/c1-31-21-16-9-12(11-25-20(16)26-27-21)5-6-15-17(23)7-8-18(19(15)24)28-32(29,30)14-4-2-3-13(22)10-14/h2-4,7-11,28H,1H3,(H,25,26,27)
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n/an/a 5n/an/an/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged recombinant human full-length ZAK expressed in baculovirus infected Sf9 insect cells using MBP as substrate after...


J Med Chem 60: 5927-5932 (2017)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mixed lineage kinase 7


(Homo sapiens (Human))
BDBM50268037
PNG
(CHEMBL4091071)
Show SMILES Fc1ccc(NS(=O)(=O)c2cccc(Cl)c2)c(F)c1C#Cc1cnc2[nH]ncc2c1
Show InChI InChI=1S/C20H11ClF2N4O2S/c21-14-2-1-3-15(9-14)30(28,29)27-18-7-6-17(22)16(19(18)23)5-4-12-8-13-11-25-26-20(13)24-10-12/h1-3,6-11,27H,(H,24,25,26)
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n/an/a 5.10n/an/an/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged recombinant human full-length ZAK expressed in baculovirus infected Sf9 insect cells using MBP as substrate after...


J Med Chem 60: 5927-5932 (2017)

More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens (Human))
BDBM50268020
PNG
(CHEMBL4104859)
Show SMILES COc1n[nH]c2ncc(cc12)C#Cc1c(F)ccc(NS(=O)(=O)c2ccccc2Cl)c1F
Show InChI InChI=1S/C21H13ClF2N4O3S/c1-31-21-14-10-12(11-25-20(14)26-27-21)6-7-13-16(23)8-9-17(19(13)24)28-32(29,30)18-5-3-2-4-15(18)22/h2-5,8-11,28H,1H3,(H,25,26,27)
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n/an/a 5.10n/an/an/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged recombinant human full-length ZAK expressed in baculovirus infected Sf9 insect cells using MBP as substrate after...


J Med Chem 60: 5927-5932 (2017)

More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens (Human))
BDBM50268015
PNG
(CHEMBL4079935)
Show SMILES COc1n[nH]c2ncc(cc12)C#Cc1c(F)ccc(NS(=O)(=O)c2cccc(OC)c2)c1F
Show InChI InChI=1S/C22H16F2N4O4S/c1-31-14-4-3-5-15(11-14)33(29,30)28-19-9-8-18(23)16(20(19)24)7-6-13-10-17-21(25-12-13)26-27-22(17)32-2/h3-5,8-12,28H,1-2H3,(H,25,26,27)
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n/an/a 7.5n/an/an/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged recombinant human full-length ZAK expressed in baculovirus infected Sf9 insect cells using MBP as substrate after...


J Med Chem 60: 5927-5932 (2017)

More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens (Human))
BDBM50268017
PNG
(CHEMBL4088739)
Show SMILES COc1n[nH]c2ncc(cc12)C#Cc1c(F)ccc(NS(=O)(=O)c2cccc(Cl)c2Cl)c1F
Show InChI InChI=1S/C21H12Cl2F2N4O3S/c1-32-21-13-9-11(10-26-20(13)27-28-21)5-6-12-15(24)7-8-16(19(12)25)29-33(30,31)17-4-2-3-14(22)18(17)23/h2-4,7-10,29H,1H3,(H,26,27,28)
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n/an/a 9.60n/an/an/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged recombinant human full-length ZAK expressed in baculovirus infected Sf9 insect cells using MBP as substrate after...


J Med Chem 60: 5927-5932 (2017)

More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens (Human))
BDBM50268014
PNG
(CHEMBL4104171)
Show SMILES COc1n[nH]c2ncc(cc12)C#Cc1c(F)ccc(NS(=O)(=O)c2cccc(C)c2)c1F
Show InChI InChI=1S/C22H16F2N4O3S/c1-13-4-3-5-15(10-13)32(29,30)28-19-9-8-18(23)16(20(19)24)7-6-14-11-17-21(25-12-14)26-27-22(17)31-2/h3-5,8-12,28H,1-2H3,(H,25,26,27)
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n/an/a 12n/an/an/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged recombinant human full-length ZAK expressed in baculovirus infected Sf9 insect cells using MBP as substrate after...


J Med Chem 60: 5927-5932 (2017)

More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens (Human))
BDBM50268011
PNG
(CHEMBL4069195)
Show SMILES COc1n[nH]c2ncc(cc12)C#Cc1c(F)ccc(NS(=O)(=O)c2ccc(Cl)cc2)c1F
Show InChI InChI=1S/C21H13ClF2N4O3S/c1-31-21-16-10-12(11-25-20(16)26-27-21)2-7-15-17(23)8-9-18(19(15)24)28-32(29,30)14-5-3-13(22)4-6-14/h3-6,8-11,28H,1H3,(H,25,26,27)
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n/an/a 17n/an/an/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged recombinant human full-length ZAK expressed in baculovirus infected Sf9 insect cells using MBP as substrate after...


J Med Chem 60: 5927-5932 (2017)

More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens (Human))
BDBM50268019
PNG
(CHEMBL4080626)
Show SMILES COc1n[nH]c2ncc(cc12)C#Cc1c(F)ccc(NS(=O)(=O)c2ccccc2)c1F
Show InChI InChI=1S/C21H14F2N4O3S/c1-30-21-16-11-13(12-24-20(16)25-26-21)7-8-15-17(22)9-10-18(19(15)23)27-31(28,29)14-5-3-2-4-6-14/h2-6,9-12,27H,1H3,(H,24,25,26)
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n/an/a 19n/an/an/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged recombinant human full-length ZAK expressed in baculovirus infected Sf9 insect cells using MBP as substrate after...


J Med Chem 60: 5927-5932 (2017)

More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens (Human))
BDBM50268038
PNG
(CHEMBL4060505)
Show SMILES Fc1ccc(NS(=O)(=O)c2cccc(Cl)c2)c(F)c1C#Cc1cnc2[nH]ccc2c1
Show InChI InChI=1S/C21H12ClF2N3O2S/c22-15-2-1-3-16(11-15)30(28,29)27-19-7-6-18(23)17(20(19)24)5-4-13-10-14-8-9-25-21(14)26-12-13/h1-3,6-12,27H,(H,25,26)
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n/an/a 23n/an/an/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged recombinant human full-length ZAK expressed in baculovirus infected Sf9 insect cells using MBP as substrate after...


J Med Chem 60: 5927-5932 (2017)

More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens (Human))
BDBM50396483
PNG
(PLX-4032 | RG 7204 | Ro 5185426 | US9388165, Refer...)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c1F
Show InChI InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28)
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n/an/a 23n/an/an/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of human ZAK (5 to 309 residues) expressed in baculovirus infected Sf9 insect cells using ZAKtide as substrate after 1 hr by mass spectrom...


J Med Chem 60: 5927-5932 (2017)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mixed lineage kinase 7


(Homo sapiens (Human))
BDBM50396483
PNG
(PLX-4032 | RG 7204 | Ro 5185426 | US9388165, Refer...)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c1F
Show InChI InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28)
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n/an/a 31n/an/an/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged recombinant human full-length ZAK expressed in baculovirus infected Sf9 insect cells using MBP as substrate after...


J Med Chem 60: 5927-5932 (2017)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mixed lineage kinase 7


(Homo sapiens (Human))
BDBM50096279
PNG
(CHEMBL3577124)
Show SMILES CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)NCCC(C)(C)C)c(F)cc1C
Show InChI InChI=1S/C23H29FN6O/c1-13-9-18(24)19(29-22(31)26-8-7-23(3,4)5)11-16(13)17-10-15-12-27-21(25-6)30-20(15)28-14(17)2/h9-12H,7-8H2,1-6H3,(H2,26,29,31)(H,25,27,28,30)
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n/an/a 39n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Competitive binding affinity to ZAK in human A375 cells after 15 mins in presence of ATP analogue


J Med Chem 58: 4165-79 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00067
BindingDB Entry DOI: 10.7270/Q2ZS2Z85
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens (Human))
BDBM50268022
PNG
(CHEMBL4087178)
Show SMILES CC(C)Oc1n[nH]c2ncc(cc12)C#Cc1c(F)ccc(NS(=O)(=O)c2cccc(Cl)c2)c1F
Show InChI InChI=1S/C23H17ClF2N4O3S/c1-13(2)33-23-18-10-14(12-27-22(18)28-29-23)6-7-17-19(25)8-9-20(21(17)26)30-34(31,32)16-5-3-4-15(24)11-16/h3-5,8-13,30H,1-2H3,(H,27,28,29)
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n/an/a 43n/an/an/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged recombinant human full-length ZAK expressed in baculovirus infected Sf9 insect cells using MBP as substrate after...


J Med Chem 60: 5927-5932 (2017)

More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens (Human))
BDBM50268023
PNG
(CHEMBL4078038)
Show SMILES Fc1ccc(NS(=O)(=O)c2cccc(Cl)c2)c(F)c1C#Cc1cnc2[nH]nc(OC3CCCC3)c2c1
Show InChI InChI=1S/C25H19ClF2N4O3S/c26-16-4-3-7-18(13-16)36(33,34)32-22-11-10-21(27)19(23(22)28)9-8-15-12-20-24(29-14-15)30-31-25(20)35-17-5-1-2-6-17/h3-4,7,10-14,17,32H,1-2,5-6H2,(H,29,30,31)
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n/an/a 144n/an/an/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged recombinant human full-length ZAK expressed in baculovirus infected Sf9 insect cells using MBP as substrate after...


J Med Chem 60: 5927-5932 (2017)

More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens (Human))
BDBM50466038
PNG
(CHEMBL4281823)
Show SMILES CCn1cc(-c2ccc3N(CCc3c2)C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc12
Show InChI InChI=1S/C25H22F3N5O2/c1-2-32-13-19(22-23(29)30-14-31-24(22)32)16-6-7-20-17(12-16)8-9-33(20)21(34)11-15-4-3-5-18(10-15)35-25(26,27)28/h3-7,10,12-14H,2,8-9,11H2,1H3,(H2,29,30,31)
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n/an/a 457n/an/an/an/an/an/a



Sichuan University/Collaborative Innovation Center of Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length human ZAK using MBP as substrate after 40 mins in presence of [gamma-33P]-ATP by scintillation counting analysi...


J Med Chem 61: 11398-11414 (2018)

More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens (Human))
BDBM50184490
PNG
(3-[6-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]...)
Show SMILES OCCCn1cnc2ccc(cc12)-c1c2CCCn2nc1-c1ccccn1
Show InChI InChI=1S/C21H21N5O/c27-12-4-10-25-14-23-16-8-7-15(13-19(16)25)20-18-6-3-11-26(18)24-21(20)17-5-1-2-9-22-17/h1-2,5,7-9,13-14,27H,3-4,6,10-12H2
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n/an/a 708n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of MLK7


J Med Chem 49: 2138-42 (2006)


Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens (Human))
BDBM50268024
PNG
(CHEMBL4085336)
Show SMILES Fc1ccc(NS(=O)(=O)c2cccc(Cl)c2)c(F)c1C#Cc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C21H12ClF2N3O2S/c22-15-2-1-3-16(11-15)30(28,29)27-20-9-7-18(23)17(21(20)24)6-4-13-5-8-19-14(10-13)12-25-26-19/h1-3,5,7-12,27H,(H,25,26)
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n/an/a 994n/an/an/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged recombinant human full-length ZAK expressed in baculovirus infected Sf9 insect cells using MBP as substrate after...


J Med Chem 60: 5927-5932 (2017)

More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens (Human))
BDBM50184486
PNG
(1-methyl-6-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[...)
Show SMILES Cn1cnc2ccc(cc12)-c1c2CCCn2nc1-c1ccccn1
Show InChI InChI=1S/C19H17N5/c1-23-12-21-14-8-7-13(11-17(14)23)18-16-6-4-10-24(16)22-19(18)15-5-2-3-9-20-15/h2-3,5,7-9,11-12H,4,6,10H2,1H3
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n/an/a 1.31E+3n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of MLK7


J Med Chem 49: 2138-42 (2006)


Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens (Human))
BDBM21492
PNG
(4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...)
Show SMILES c1[nH]nc(c1-c1ccnc2ccccc12)-c1ccccn1
Show InChI InChI=1S/C17H12N4/c1-2-6-15-13(5-1)12(8-10-19-15)14-11-20-21-17(14)16-7-3-4-9-18-16/h1-11H,(H,20,21)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of MLK7


J Med Chem 49: 2138-42 (2006)


Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens (Human))
BDBM50184483
PNG
(1-methyl-6-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4...)
Show SMILES Cc1cccc(n1)-c1nn2CCCc2c1-c1ccc2ncn(C)c2c1
Show InChI InChI=1S/C20H19N5/c1-13-5-3-6-16(22-13)20-19(17-7-4-10-25(17)23-20)14-8-9-15-18(11-14)24(2)12-21-15/h3,5-6,8-9,11-12H,4,7,10H2,1-2H3
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n/an/a 2.34E+3n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of MLK7


J Med Chem 49: 2138-42 (2006)


Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens (Human))
BDBM50184489
PNG
(3-(6-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrr...)
Show SMILES Cc1cccc(n1)-c1nn2CCCc2c1-c1ccc2ncn(CCCO)c2c1
Show InChI InChI=1S/C22H23N5O/c1-15-5-2-6-18(24-15)22-21(19-7-3-11-27(19)25-22)16-8-9-17-20(13-16)26(14-23-17)10-4-12-28/h2,5-6,8-9,13-14,28H,3-4,7,10-12H2,1H3
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n/an/a 2.81E+3n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of MLK7


J Med Chem 49: 2138-42 (2006)


Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens (Human))
BDBM50184491
PNG
(6-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]p...)
Show SMILES C(CN1CCCC1)Cn1cnc2ccc(cc12)-c1c2CCCn2nc1-c1ccccn1
Show InChI InChI=1S/C25H28N6/c1-2-11-26-21(7-1)25-24(22-8-5-16-31(22)28-25)19-9-10-20-23(17-19)30(18-27-20)15-6-14-29-12-3-4-13-29/h1-2,7,9-11,17-18H,3-6,8,12-16H2
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n/an/a 4.88E+3n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of MLK7


J Med Chem 49: 2138-42 (2006)


Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens (Human))
BDBM50184487
PNG
(4-(3-(6-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-p...)
Show SMILES Cc1cccc(n1)-c1nn2CCCc2c1-c1ccc2ncn(CCCN3CCOCC3)c2c1
Show InChI InChI=1S/C26H30N6O/c1-19-5-2-6-22(28-19)26-25(23-7-3-12-32(23)29-26)20-8-9-21-24(17-20)31(18-27-21)11-4-10-30-13-15-33-16-14-30/h2,5-6,8-9,17-18H,3-4,7,10-16H2,1H3
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n/an/a 8.48E+3n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of MLK7


J Med Chem 49: 2138-42 (2006)


Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens (Human))
BDBM50401152
PNG
(CHEMBL2205766)
Show SMILES CC(C)(C)NS(=O)(=O)c1cncc(c1)-c1ccn2nc(N)nc2c1
Show InChI InChI=1S/C15H18N6O2S/c1-15(2,3)20-24(22,23)12-6-11(8-17-9-12)10-4-5-21-13(7-10)18-14(16)19-21/h4-9,20H,1-3H3,(H2,16,19)
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n/an/a<1.00E+4n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of ZAK


Bioorg Med Chem Lett 22: 4613-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.090
BindingDB Entry DOI: 10.7270/Q2HQ412B
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens (Human))
BDBM50499634
PNG
(CHEMBL3741589)
Show SMILES OC(=O)C1CN(Cc2ccc(OCc3ccc(Cl)c(Cl)c3)cc2)C1
Show InChI InChI=1S/C18H17Cl2NO3/c19-16-6-3-13(7-17(16)20)11-24-15-4-1-12(2-5-15)8-21-9-14(10-21)18(22)23/h1-7,14H,8-11H2,(H,22,23)
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AbbVie Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of ZAK (unknown origin)


J Med Chem 58: 9154-70 (2015)

More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens (Human))
BDBM50135286
PNG
(CHEMBL3745885)
Show SMILES Cn1c2nc(Nc3ccc4[nH]ccc4c3)ncc2cc(c1=O)S(=O)(=O)c1ccc(F)cc1F
Show InChI InChI=1S/C22H15F2N5O3S/c1-29-20-13(9-19(21(29)30)33(31,32)18-5-2-14(23)10-16(18)24)11-26-22(28-20)27-15-3-4-17-12(8-15)6-7-25-17/h2-11,25H,1H3,(H,26,27,28)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Icahn School of Medicine at Mount Sinai

Curated by ChEMBL


Assay Description
Inhibition of human ZAK using MBP substrate


Bioorg Med Chem 24: 521-44 (2016)


Article DOI: 10.1016/j.bmc.2015.11.045
BindingDB Entry DOI: 10.7270/Q24Q7WT8
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens (Human))
BDBM50150698
PNG
(3-(imidazo[1,2-a]pyridin-3-yl)-4-(2-(morpholine-4-...)
Show SMILES O=C(N1CCOCC1)N1CCn2cc(C3=C(C(=O)NC3=O)c3cnc4ccccn34)c3cccc(C1)c23
Show InChI InChI=1S/C27H24N6O4/c34-25-22(23(26(35)29-25)20-14-28-21-6-1-2-7-33(20)21)19-16-31-8-9-32(27(36)30-10-12-37-13-11-30)15-17-4-3-5-18(19)24(17)31/h1-7,14,16H,8-13,15H2,(H,29,34,35)
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n/an/a 1.34E+4n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of human MLK7


J Med Chem 47: 3934-7 (2004)


Article DOI: 10.1021/jm049768a
BindingDB Entry DOI: 10.7270/Q2B56KG1
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens (Human))
BDBM50184480
PNG
(CHEMBL202730 | dimethyl-{3-[6-(2-pyridin-2-yl-5,6-...)
Show SMILES CN(C)CCCn1cnc2ccc(cc12)-c1c2CCCn2nc1-c1ccccn1
Show InChI InChI=1S/C23H26N6/c1-27(2)12-6-13-28-16-25-18-10-9-17(15-21(18)28)22-20-8-5-14-29(20)26-23(22)19-7-3-4-11-24-19/h3-4,7,9-11,15-16H,5-6,8,12-14H2,1-2H3
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n/an/a 1.59E+4n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of MLK7


J Med Chem 49: 2138-42 (2006)


Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens (Human))
BDBM50184488
PNG
(6-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrol...)
Show SMILES Cc1cccc(n1)-c1nn2CCCc2c1-c1ccc2nc[nH]c2c1
Show InChI InChI=1S/C19H17N5/c1-12-4-2-5-15(22-12)19-18(17-6-3-9-24(17)23-19)13-7-8-14-16(10-13)21-11-20-14/h2,4-5,7-8,10-11H,3,6,9H2,1H3,(H,20,21)
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n/an/a 1.59E+4n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of MLK7


J Med Chem 49: 2138-42 (2006)


Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens (Human))
BDBM50184481
PNG
(1-methyl-5-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[...)
Show SMILES Cn1ccc2cc(ccc12)-c1c2CCCn2nc1-c1ccccn1
Show InChI InChI=1S/C20H18N4/c1-23-12-9-14-13-15(7-8-17(14)23)19-18-6-4-11-24(18)22-20(19)16-5-2-3-10-21-16/h2-3,5,7-10,12-13H,4,6,11H2,1H3
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n/an/a 1.66E+4n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of MLK7


J Med Chem 49: 2138-42 (2006)


Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens (Human))
BDBM50184492
PNG
(5-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]p...)
Show SMILES C1Cc2c(c(nn2C1)-c1ccccn1)-c1ccc2nc[nH]c2c1
Show InChI InChI=1S/C18H15N5/c1-2-8-19-14(4-1)18-17(16-5-3-9-23(16)22-18)12-6-7-13-15(10-12)21-11-20-13/h1-2,4,6-8,10-11H,3,5,9H2,(H,20,21)
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n/an/a>2.00E+4n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of MLK7


J Med Chem 49: 2138-42 (2006)


Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens (Human))
BDBM50184484
PNG
(5-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyr...)
Show SMILES C(COC1CCCCO1)Cn1cnc2cc(ccc12)-c1c2CCCn2nc1-c1ccccn1
Show InChI InChI=1/C26H29N5O2/c1-3-12-27-20(7-1)26-25(23-8-5-14-31(23)29-26)19-10-11-22-21(17-19)28-18-30(22)13-6-16-33-24-9-2-4-15-32-24/h1,3,7,10-12,17-18,24H,2,4-6,8-9,13-16H2
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Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of MLK7


J Med Chem 49: 2138-42 (2006)


Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens (Human))
BDBM50184495
PNG
(1-methyl-5-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-...)
Show SMILES Cc1cccc(n1)-c1nn2CCCc2c1-c1ccc2n(C)ccc2c1
Show InChI InChI=1S/C21H20N4/c1-14-5-3-6-17(22-14)21-20(19-7-4-11-25(19)23-21)16-8-9-18-15(13-16)10-12-24(18)2/h3,5-6,8-10,12-13H,4,7,11H2,1-2H3
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Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of MLK7


J Med Chem 49: 2138-42 (2006)


Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens (Human))
BDBM50184494
PNG
(6-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrol...)
Show SMILES Cc1cccc(n1)-c1nn2CCCc2c1-c1ccc2ncn(CCCN3CCCCC3)c2c1
Show InChI InChI=1S/C27H32N6/c1-20-8-5-9-23(29-20)27-26(24-10-6-17-33(24)30-27)21-11-12-22-25(18-21)32(19-28-22)16-7-15-31-13-3-2-4-14-31/h5,8-9,11-12,18-19H,2-4,6-7,10,13-17H2,1H3
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Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of MLK7


J Med Chem 49: 2138-42 (2006)


Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens (Human))
BDBM50184496
PNG
(CHEMBL441176 | dimethyl-(3-{6-[2-(6-methyl-pyridin...)
Show SMILES CN(C)CCCn1cnc2ccc(cc12)-c1c2CCCn2nc1-c1cccc(C)n1
Show InChI InChI=1S/C24H28N6/c1-17-7-4-8-20(26-17)24-23(21-9-5-14-30(21)27-24)18-10-11-19-22(15-18)29(16-25-19)13-6-12-28(2)3/h4,7-8,10-11,15-16H,5-6,9,12-14H2,1-3H3
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Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of MLK7


J Med Chem 49: 2138-42 (2006)


Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens (Human))
BDBM50184493
PNG
(CHEMBL203791 | N,N-diethyl-3-(6-(2-(6-methylpyridi...)
Show SMILES CCN(CC)CCCn1cnc2ccc(cc12)-c1c2CCCn2nc1-c1cccc(C)n1
Show InChI InChI=1S/C26H32N6/c1-4-30(5-2)14-8-15-31-18-27-21-13-12-20(17-24(21)31)25-23-11-7-16-32(23)29-26(25)22-10-6-9-19(3)28-22/h6,9-10,12-13,17-18H,4-5,7-8,11,14-16H2,1-3H3
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Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of MLK7


J Med Chem 49: 2138-42 (2006)


Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens (Human))
BDBM50184498
PNG
(5-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyr...)
Show SMILES C1Cc2c(c(nn2C1)-c1ccccn1)-c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C19H16N4/c1-2-9-20-16(4-1)19-18(17-5-3-11-23(17)22-19)14-6-7-15-13(12-14)8-10-21-15/h1-2,4,6-10,12,21H,3,5,11H2
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Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of MLK7


J Med Chem 49: 2138-42 (2006)


Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens (Human))
BDBM50184497
PNG
(6-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrol...)
Show SMILES Cc1cccc(n1)-c1nn2CCCc2c1-c1ccc2ncn(CCCN3CCCC3)c2c1
Show InChI InChI=1S/C26H30N6/c1-19-7-4-8-22(28-19)26-25(23-9-5-16-32(23)29-26)20-10-11-21-24(17-20)31(18-27-21)15-6-14-30-12-2-3-13-30/h4,7-8,10-11,17-18H,2-3,5-6,9,12-16H2,1H3
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Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of MLK7


J Med Chem 49: 2138-42 (2006)


Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens (Human))
BDBM50184482
PNG
(1-methyl-5-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[...)
Show SMILES Cn1cnc2cc(ccc12)-c1c2CCCn2nc1-c1ccccn1
Show InChI InChI=1S/C19H17N5/c1-23-12-21-15-11-13(7-8-16(15)23)18-17-6-4-10-24(17)22-19(18)14-5-2-3-9-20-14/h2-3,5,7-9,11-12H,4,6,10H2,1H3
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Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of MLK7


J Med Chem 49: 2138-42 (2006)


Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens (Human))
BDBM50150700
PNG
(7-(4-Imidazo[1,2-a]pyridin-3-yl-2,5-dioxo-2,5-dihy...)
Show SMILES CC(C)OC(=O)N1CCn2cc(C3=C(C(=O)NC3=O)c3cnc4ccccn34)c3cccc(C1)c23
Show InChI InChI=1S/C26H23N5O4/c1-15(2)35-26(34)30-11-10-29-14-18(17-7-5-6-16(13-30)23(17)29)21-22(25(33)28-24(21)32)19-12-27-20-8-3-4-9-31(19)20/h3-9,12,14-15H,10-11,13H2,1-2H3,(H,28,32,33)
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n/an/a>2.00E+4n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of human MLK7


J Med Chem 47: 3934-7 (2004)


Article DOI: 10.1021/jm049768a
BindingDB Entry DOI: 10.7270/Q2B56KG1
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens (Human))
BDBM50150702
PNG
(3-Imidazo[1,2-a]pyridin-3-yl-4-[2-(piperidine-1-ca...)
Show SMILES O=C(N1CCCCC1)N1CCn2cc(C3=C(C(=O)NC3=O)c3cnc4ccccn34)c3cccc(C1)c23
Show InChI InChI=1S/C28H26N6O3/c35-26-23(24(27(36)30-26)21-15-29-22-9-2-5-12-34(21)22)20-17-32-13-14-33(28(37)31-10-3-1-4-11-31)16-18-7-6-8-19(20)25(18)32/h2,5-9,12,15,17H,1,3-4,10-11,13-14,16H2,(H,30,35,36)
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n/an/a>2.00E+4n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of human MLK7


J Med Chem 47: 3934-7 (2004)


Article DOI: 10.1021/jm049768a
BindingDB Entry DOI: 10.7270/Q2B56KG1
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens (Human))
BDBM50150701
PNG
(7-(4-(H-imidazo[1,2-a]pyridin-3-yl)-2,5-dioxo-2,5-...)
Show SMILES CN(C)C(=O)N1CCn2cc(C3=C(C(=O)NC3=O)c3cnc4ccccn34)c3cccc(C1)c23
Show InChI InChI=1S/C25H22N6O3/c1-28(2)25(34)30-11-10-29-14-17(16-7-5-6-15(13-30)22(16)29)20-21(24(33)27-23(20)32)18-12-26-19-8-3-4-9-31(18)19/h3-9,12,14H,10-11,13H2,1-2H3,(H,27,32,33)
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n/an/a>2.00E+4n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of human MLK7


J Med Chem 47: 3934-7 (2004)


Article DOI: 10.1021/jm049768a
BindingDB Entry DOI: 10.7270/Q2B56KG1
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens (Human))
BDBM50150699
PNG
(3-(9-fluoro-2-(piperidine-1-carbonyl)-1,2,3,4-tetr...)
Show SMILES Fc1cc2CN(CCn3cc(C4=C(C(=O)NC4=O)c4cnc5ccccn45)c(c1)c23)C(=O)N1CCCCC1
Show InChI InChI=1S/C28H25FN6O3/c29-18-12-17-15-34(28(38)32-7-3-1-4-8-32)11-10-33-16-20(19(13-18)25(17)33)23-24(27(37)31-26(23)36)21-14-30-22-6-2-5-9-35(21)22/h2,5-6,9,12-14,16H,1,3-4,7-8,10-11,15H2,(H,31,36,37)
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n/an/a>2.00E+4n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of human MLK7


J Med Chem 47: 3934-7 (2004)


Article DOI: 10.1021/jm049768a
BindingDB Entry DOI: 10.7270/Q2B56KG1
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens (Human))
BDBM50184485
PNG
(5-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo...)
Show SMILES Cc1cccc(n1)-c1nn2CCCc2c1-c1ccc2n(CCCOC3CCCCO3)cnc2c1
Show InChI InChI=1/C27H31N5O2/c1-19-7-4-8-21(29-19)27-26(24-9-5-14-32(24)30-27)20-11-12-23-22(17-20)28-18-31(23)13-6-16-34-25-10-2-3-15-33-25/h4,7-8,11-12,17-18,25H,2-3,5-6,9-10,13-16H2,1H3
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Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of MLK7


J Med Chem 49: 2138-42 (2006)


Article DOI: 10.1021/jm058209g
BindingDB Entry DOI: 10.7270/Q2V40TS0
More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens (Human))
BDBM50268021
PNG
(CHEMBL4067092)
Show SMILES Cn1ncc2cc(cnc12)C#Cc1c(F)ccc(NS(=O)(=O)c2cccc(Cl)c2)c1F
Show InChI InChI=1S/C21H13ClF2N4O2S/c1-28-21-14(12-26-28)9-13(11-25-21)5-6-17-18(23)7-8-19(20(17)24)27-31(29,30)16-4-2-3-15(22)10-16/h2-4,7-12,27H,1H3
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Macau

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged recombinant human full-length ZAK expressed in baculovirus infected Sf9 insect cells using MBP as substrate after...


J Med Chem 60: 5927-5932 (2017)

More data for this
Ligand-Target Pair
Mixed lineage kinase 7


(Homo sapiens (Human))
BDBM50224883
PNG
(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Show SMILES Clc1cc2NC(=O)Nc3cnc(C#N)c(OCCCCOc2cc1NCc1cncs1)n3
Show InChI InChI=1S/C20H18ClN7O3S/c21-13-5-15-17(6-14(13)24-9-12-8-23-11-32-12)30-3-1-2-4-31-19-16(7-22)25-10-18(27-19)28-20(29)26-15/h5-6,8,10-11,24H,1-4,9H2,(H2,26,27,28,29)
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>8.57E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ZAK


Bioorg Med Chem Lett 17: 6593-601 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.063
BindingDB Entry DOI: 10.7270/Q2X067WT
More data for this
Ligand-Target Pair
ZAK


(Homo sapiens (Human))
BDBM31085
PNG
(1-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluorom...)
Show SMILES CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C26H30F3N7O2/c1-3-35-10-12-36(13-11-35)16-18-4-5-20(14-22(18)26(27,28)29)34-25(37)33-19-6-8-21(9-7-19)38-24-15-23(30-2)31-17-32-24/h4-9,14-15,17H,3,10-13,16H2,1-2H3,(H,30,31,32)(H2,33,34,37)
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n/an/an/a 2.30n/an/an/an/an/a



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


PubChem Bioassay (2008)


Article DOI: 10.1021/jm0503751
BindingDB Entry DOI: 10.7270/Q2HD7T1F
More data for this
Ligand-Target Pair
ZAK


(Homo sapiens (Human))
BDBM26300
PNG
(2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}qu...)
Show SMILES CCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)n[nH]3)ncnc2c1
Show InChI InChI=1S/C26H30FN7O3/c1-2-34(10-11-35)9-4-12-37-21-7-8-22-23(16-21)28-17-29-26(22)31-24-14-20(32-33-24)15-25(36)30-19-6-3-5-18(27)13-19/h3,5-8,13-14,16-17,35H,2,4,9-12,15H2,1H3,(H,30,36)(H2,28,29,31,32,33)
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n/an/an/a 1.70E+3n/an/an/an/an/a



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


PubChem Bioassay (2008)


Article DOI: 10.1021/jm0503751
BindingDB Entry DOI: 10.7270/Q2HD7T1F
More data for this
Ligand-Target Pair
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