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Compile Data Set for Download or QSAR

Found 427 hits Enz. Inhib. hit(s) with Target = 'Motilin receptor'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Motilin receptor


(Oryctolagus cuniculus)
BDBM50268430
PNG
((S)-N-((S)-1-amino-3-(3-tert-butyl-4-hydroxyphenyl...)
Show SMILES CC(C)[C@H](N(C)C(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)c(c1)C(C)(C)C)C(N)=O
Show InChI InChI=1S/C28H40N4O4/c1-17(2)24(32(6)27(36)21(29)15-18-10-8-7-9-11-18)26(35)31-22(25(30)34)16-19-12-13-23(33)20(14-19)28(3,4)5/h7-14,17,21-22,24,33H,15-16,29H2,1-6H3,(H2,30,34)(H,31,35)/t21-,22-,24-/m0/s1
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n/an/a 1.10n/an/an/an/an/an/a



Chugai Pharmaceutical Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]motilin from MTL receptor in rabbit duodenum homogenate


Citation and Details
More data for this
Ligand-Target Pair
Motilin receptor


(Oryctolagus cuniculus)
BDBM50421355
PNG
(CHEMBL289955)
Show SMILES CCC1OC(=O)C(C)C(O[C@H]2C[C@](C)(CC(C)O2)OC)C(C)[C@@H](OC2OC(C)CC([C@H]2O)N(C)C(C)C)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC
Show InChI InChI=1S/C40H69NO11/c1-16-29-40(12,46-15)34(43)25(7)32-22(4)18-39(11,52-32)35(51-37-31(42)28(17-23(5)48-37)41(13)21(2)3)26(8)33(27(9)36(44)49-29)50-30-20-38(10,45-14)19-24(6)47-30/h21,23-31,33,35,37,42H,16-20H2,1-15H3/t23?,24?,25-,26?,27?,28?,29?,30-,31+,33?,35+,37?,38-,39-,40+/m0/s1
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n/an/a 1.80n/an/an/an/an/an/a


TBA

Assay Description
In vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tis...


Citation and Details
More data for this
Ligand-Target Pair
Motilin receptor


(Oryctolagus cuniculus)
BDBM50268433
PNG
((S)-2-((S)-2-amino-N-methyl-3-phenylpropanamido)-N...)
Show SMILES CC(C)[C@H](N(C)C(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@H](C)Cc1ccc(O)c(c1)C(C)(C)C
Show InChI InChI=1S/C28H41N3O3/c1-18(2)25(31(7)27(34)23(29)17-20-11-9-8-10-12-20)26(33)30-19(3)15-21-13-14-24(32)22(16-21)28(4,5)6/h8-14,16,18-19,23,25,32H,15,17,29H2,1-7H3,(H,30,33)/t19-,23+,25+/m1/s1
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n/an/a 1.90n/an/an/an/an/an/a



Chugai Pharmaceutical Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]motilin from MTL receptor in rabbit duodenum homogenate


Citation and Details
More data for this
Ligand-Target Pair
Motilin receptor


(Oryctolagus cuniculus)
BDBM50421358
PNG
(CHEMBL45141)
Show SMILES CCC1OC(=O)C(C)C(O[C@H]2C[C@](C)(CC(C)O2)OC)C(C)[C@@H](OC2CC(CC(C)O2)N(C)C(C)C)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC
Show InChI InChI=1S/C40H69NO10/c1-16-30-40(12,45-15)35(42)26(7)33-23(4)19-39(11,51-33)36(50-31-18-29(17-24(5)46-31)41(13)22(2)3)27(8)34(28(9)37(43)48-30)49-32-21-38(10,44-14)20-25(6)47-32/h22,24-32,34,36H,16-21H2,1-15H3/t24?,25?,26-,27?,28?,29?,30?,31?,32-,34?,36+,38-,39-,40+/m0/s1
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n/an/a 1.90n/an/an/an/an/an/a


TBA

Assay Description
In vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenate


Citation and Details
More data for this
Ligand-Target Pair
Motilin receptor


(Homo sapiens)
BDBM50214268
PNG
((5R,8R,11S)-8-(propan-2-yl)-11-(pyrrolidin-1-ylmet...)
Show SMILES CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(c2)C(F)(F)F)NCCOc2ccccc2CCCNC(=O)[C@H](CN2CCCC2)NC1=O
Show InChI InChI=1S/C33H44F3N5O4/c1-22(2)29-32(44)39-27(21-41-16-5-6-17-41)30(42)38-14-8-11-24-10-3-4-13-28(24)45-18-15-37-26(31(43)40-29)20-23-9-7-12-25(19-23)33(34,35)36/h3-4,7,9-10,12-13,19,22,26-27,29,37H,5-6,8,11,14-18,20-21H2,1-2H3,(H,38,42)(H,39,44)(H,40,43)/t26-,27+,29-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Tranzyme Pharma Inc.

Curated by ChEMBL


Assay Description
Antagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assay


Citation and Details
More data for this
Ligand-Target Pair
Motilin receptor


(Oryctolagus cuniculus)
BDBM50421357
PNG
(CHEMBL297168)
Show SMILES CCC1OC(=O)C(C)C(O[C@H]2C[C@](C)(CC(C)O2)OC)C(C)[C@@H](OC2OC(C)CC([C@H]2O)N(C)C)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC
Show InChI InChI=1S/C38H65NO11/c1-15-27-38(10,44-14)32(41)23(5)30-20(2)17-37(9,50-30)33(49-35-29(40)26(39(11)12)16-21(3)46-35)24(6)31(25(7)34(42)47-27)48-28-19-36(8,43-13)18-22(4)45-28/h21-29,31,33,35,40H,15-19H2,1-14H3/t21?,22?,23-,24?,25?,26?,27?,28-,29+,31?,33+,35?,36-,37-,38+/m0/s1
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n/an/a 2.30n/an/an/an/an/an/a


TBA

Assay Description
In vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenate


Citation and Details
More data for this
Ligand-Target Pair
Motilin receptor


(Oryctolagus cuniculus)
BDBM50421355
PNG
(CHEMBL289955)
Show SMILES CCC1OC(=O)C(C)C(O[C@H]2C[C@](C)(CC(C)O2)OC)C(C)[C@@H](OC2OC(C)CC([C@H]2O)N(C)C(C)C)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC
Show InChI InChI=1S/C40H69NO11/c1-16-29-40(12,46-15)34(43)25(7)32-22(4)18-39(11,52-32)35(51-37-31(42)28(17-23(5)48-37)41(13)21(2)3)26(8)33(27(9)36(44)49-29)50-30-20-38(10,45-14)19-24(6)47-30/h21,23-31,33,35,37,42H,16-20H2,1-15H3/t23?,24?,25-,26?,27?,28?,29?,30-,31+,33?,35+,37?,38-,39-,40+/m0/s1
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n/an/a 2.5n/an/an/an/an/an/a


TBA

Assay Description
In vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenate


Citation and Details
More data for this
Ligand-Target Pair
Motilin receptor


(Homo sapiens)
BDBM50214266
PNG
((5R,8R,11S)-11-[(methylamino)methyl]-8-(propan-2-y...)
Show SMILES CNC[C@@H]1NC(=O)[C@H](NC(=O)[C@@H](Cc2cccc(c2)C(F)(F)F)NCCOc2ccccc2CCCNC1=O)C(C)C
Show InChI InChI=1S/C30H40F3N5O4/c1-19(2)26-29(41)37-24(18-34-3)27(39)36-13-7-10-21-9-4-5-12-25(21)42-15-14-35-23(28(40)38-26)17-20-8-6-11-22(16-20)30(31,32)33/h4-6,8-9,11-12,16,19,23-24,26,34-35H,7,10,13-15,17-18H2,1-3H3,(H,36,39)(H,37,41)(H,38,40)/t23-,24+,26-/m1/s1
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n/an/a 3n/an/an/an/an/an/a



Tranzyme Pharma Inc.

Curated by ChEMBL


Assay Description
Antagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assay


Citation and Details
More data for this
Ligand-Target Pair
Motilin receptor


(Homo sapiens)
BDBM50421366
PNG
(CHEMBL353526)
Show SMILES CCC1OC(=O)C(C)C(C[C@@H](OC2OC(C)CC([C@H]2O)N(C)CC)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O)OC1C[C@@](C)(OC)[C@@H](O)C(C)O1
Show InChI InChI=1S/C37H65NO12/c1-13-26-37(10,43)31(40)22(6)30-19(3)17-35(8,50-30)27(49-34-29(39)24(38(11)14-2)15-20(4)45-34)16-25(21(5)33(42)48-26)47-28-18-36(9,44-12)32(41)23(7)46-28/h20-29,31-32,34,39-41,43H,13-18H2,1-12H3/t20?,21?,22-,23?,24?,25?,26?,27+,28?,29+,31+,32-,34?,35-,36+,37+/m0/s1
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n/an/a 3.20n/an/an/an/an/an/a


TBA

Assay Description
Compound was tested for in vitro motilin receptor binding affinity


Citation and Details
More data for this
Ligand-Target Pair
Motilin receptor


(Oryctolagus cuniculus)
BDBM50421354
PNG
(CHEMBL26966)
Show SMILES CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC([C@H]2O)N(C)CC)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O
Show InChI InChI=1S/C38H67NO12/c1-14-26-38(11,44)31(41)21(5)29-19(3)17-37(10,51-29)33(50-35-28(40)25(39(12)15-2)16-20(4)46-35)22(6)30(23(7)34(43)48-26)49-27-18-36(9,45-13)32(42)24(8)47-27/h20-28,30-33,35,40-42,44H,14-18H2,1-13H3/t20?,21-,22?,23?,24?,25?,26?,27-,28+,30?,31+,32-,33+,35?,36+,37-,38+/m0/s1
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TBA

Assay Description
In vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenate


Citation and Details
More data for this
Ligand-Target Pair
Motilin receptor


(Oryctolagus cuniculus)
BDBM50421354
PNG
(CHEMBL26966)
Show SMILES CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC([C@H]2O)N(C)CC)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O
Show InChI InChI=1S/C38H67NO12/c1-14-26-38(11,44)31(41)21(5)29-19(3)17-37(10,51-29)33(50-35-28(40)25(39(12)15-2)16-20(4)46-35)22(6)30(23(7)34(43)48-26)49-27-18-36(9,45-13)32(42)24(8)47-27/h20-28,30-33,35,40-42,44H,14-18H2,1-13H3/t20?,21-,22?,23?,24?,25?,26?,27-,28+,30?,31+,32-,33+,35?,36+,37-,38+/m0/s1
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n/an/a 3.20n/an/an/an/an/an/a


TBA

Assay Description
Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50


Citation and Details
More data for this
Ligand-Target Pair
Motilin receptor


(Homo sapiens)
BDBM85846
PNG
(CAS_33396-29-1 | EM523 | Erythromycin A 6,9-enolet...)
Show SMILES CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O
Show InChI InChI=1S/C37H65NO12/c1-14-25-37(10,43)30(40)20(4)28-18(2)16-36(9,50-28)32(49-34-27(39)24(38(11)12)15-19(3)45-34)21(5)29(22(6)33(42)47-25)48-26-17-35(8,44-13)31(41)23(7)46-26/h19-27,29-32,34,39-41,43H,14-17H2,1-13H3/t19-,20+,21+,22-,23+,24+,25-,26+,27-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1
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n/an/a 3.40n/an/an/an/an/an/a


TBA

Assay Description
Compound was tested for in vitro motilin receptor binding affinity


Citation and Details
More data for this
Ligand-Target Pair
Motilin receptor


(Oryctolagus cuniculus)
BDBM50421356
PNG
(CHEMBL43313)
Show SMILES CCC1OC(=O)C(C)C(O[C@H]2C[C@](C)(CC(C)O2)OC)C(C)[C@@H](OC2OC(C)CC([C@H]2O)N(C)CC)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC
Show InChI InChI=1S/C39H67NO11/c1-15-28-39(11,45-14)33(42)24(6)31-21(3)18-38(10,51-31)34(50-36-30(41)27(40(12)16-2)17-22(4)47-36)25(7)32(26(8)35(43)48-28)49-29-20-37(9,44-13)19-23(5)46-29/h22-30,32,34,36,41H,15-20H2,1-14H3/t22?,23?,24-,25?,26?,27?,28?,29-,30+,32?,34+,36?,37-,38-,39+/m0/s1
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TBA

Assay Description
In vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenate


Citation and Details
More data for this
Ligand-Target Pair
Motilin receptor


(Oryctolagus cuniculus)
BDBM50421349
PNG
(CHEMBL265495)
Show SMILES CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC([C@H]2O)N(C)CC)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC
Show InChI InChI=1S/C39H67NO12/c1-15-27-39(11,46-14)32(42)22(5)30-20(3)18-38(10,52-30)34(51-36-29(41)26(40(12)16-2)17-21(4)47-36)23(6)31(24(7)35(44)49-27)50-28-19-37(9,45-13)33(43)25(8)48-28/h21-29,31,33-34,36,41,43H,15-19H2,1-14H3/t21?,22-,23?,24?,25?,26?,27?,28-,29+,31?,33-,34+,36?,37+,38-,39+/m0/s1
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TBA

Assay Description
Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50


Citation and Details
More data for this
Ligand-Target Pair
Motilin receptor


(Oryctolagus cuniculus)
BDBM50421349
PNG
(CHEMBL265495)
Show SMILES CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC([C@H]2O)N(C)CC)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC
Show InChI InChI=1S/C39H67NO12/c1-15-27-39(11,46-14)32(42)22(5)30-20(3)18-38(10,52-30)34(51-36-29(41)26(40(12)16-2)17-21(4)47-36)23(6)31(24(7)35(44)49-27)50-28-19-37(9,45-13)33(43)25(8)48-28/h21-29,31,33-34,36,41,43H,15-19H2,1-14H3/t21?,22-,23?,24?,25?,26?,27?,28-,29+,31?,33-,34+,36?,37+,38-,39+/m0/s1
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TBA

Assay Description
In vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenate


Citation and Details
More data for this
Ligand-Target Pair
Motilin receptor


(Oryctolagus cuniculus)
BDBM50421356
PNG
(CHEMBL43313)
Show SMILES CCC1OC(=O)C(C)C(O[C@H]2C[C@](C)(CC(C)O2)OC)C(C)[C@@H](OC2OC(C)CC([C@H]2O)N(C)CC)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC
Show InChI InChI=1S/C39H67NO11/c1-15-28-39(11,45-14)33(42)24(6)31-21(3)18-38(10,51-31)34(50-36-30(41)27(40(12)16-2)17-22(4)47-36)25(7)32(26(8)35(43)48-28)49-29-20-37(9,44-13)19-23(5)46-29/h22-30,32,34,36,41H,15-20H2,1-14H3/t22?,23?,24-,25?,26?,27?,28?,29-,30+,32?,34+,36?,37-,38-,39+/m0/s1
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n/an/a 3.80n/an/an/an/an/an/a


TBA

Assay Description
In vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tis...


Citation and Details
More data for this
Ligand-Target Pair
Motilin receptor


(Oryctolagus cuniculus)
BDBM50421357
PNG
(CHEMBL297168)
Show SMILES CCC1OC(=O)C(C)C(O[C@H]2C[C@](C)(CC(C)O2)OC)C(C)[C@@H](OC2OC(C)CC([C@H]2O)N(C)C)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC
Show InChI InChI=1S/C38H65NO11/c1-15-27-38(10,44-14)32(41)23(5)30-20(2)17-37(9,50-30)33(49-35-29(40)26(39(11)12)16-21(3)46-35)24(6)31(25(7)34(42)47-27)48-28-19-36(8,43-13)18-22(4)45-28/h21-29,31,33,35,40H,15-19H2,1-14H3/t21?,22?,23-,24?,25?,26?,27?,28-,29+,31?,33+,35?,36-,37-,38+/m0/s1
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n/an/a 3.90n/an/an/an/an/an/a


TBA

Assay Description
In vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tis...


Citation and Details
More data for this
Ligand-Target Pair
Motilin receptor


(Oryctolagus cuniculus)
BDBM50268432
PNG
((S)-N-((S)-1-amino-3-(3-tert-butyl-4-hydroxyphenyl...)
Show SMILES CC(C)[C@H](N(C)C(=O)[C@@H](N)Cc1ccccc1)C(=O)N(C)[C@@H](Cc1ccc(O)c(c1)C(C)(C)C)C(N)=O
Show InChI InChI=1S/C29H42N4O4/c1-18(2)25(33(7)27(36)22(30)16-19-11-9-8-10-12-19)28(37)32(6)23(26(31)35)17-20-13-14-24(34)21(15-20)29(3,4)5/h8-15,18,22-23,25,34H,16-17,30H2,1-7H3,(H2,31,35)/t22-,23-,25-/m0/s1
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n/an/a 4.30n/an/an/an/an/an/a



Chugai Pharmaceutical Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]motilin from MTL receptor in rabbit duodenum homogenate


Citation and Details
More data for this
Ligand-Target Pair
Motilin receptor


(Homo sapiens)
BDBM50421369
PNG
(CHEMBL262052)
Show SMILES CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC([C@H]2O)N(C)CC)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)OC
Show InChI InChI=1S/C39H69NO12/c1-15-27-39(11,46-14)32(42)22(5)30-20(3)18-38(10,52-30)34(51-36-29(41)26(40(12)16-2)17-21(4)47-36)23(6)31(24(7)35(44)49-27)50-28-19-37(9,45-13)33(43)25(8)48-28/h21-29,31-34,36,41-43H,15-19H2,1-14H3/t21?,22-,23?,24?,25?,26?,27?,28-,29+,31?,32+,33-,34+,36?,37+,38-,39+/m0/s1
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Article
n/an/a 4.70n/an/an/an/an/an/a


TBA

Assay Description
Compound was tested for in vitro motilin receptor binding affinity


Citation and Details
More data for this
Ligand-Target Pair
Motilin receptor


(Oryctolagus cuniculus)
BDBM50421351
PNG
(CHEMBL27424)
Show SMILES CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC([C@H]2O)N(C)C(C)C)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC
Show InChI InChI=1S/C40H69NO12/c1-16-28-40(12,47-15)33(43)23(6)31-21(4)18-39(11,53-31)35(52-37-30(42)27(17-22(5)48-37)41(13)20(2)3)24(7)32(25(8)36(45)50-28)51-29-19-38(10,46-14)34(44)26(9)49-29/h20,22-30,32,34-35,37,42,44H,16-19H2,1-15H3/t22?,23-,24?,25?,26?,27?,28?,29-,30+,32?,34-,35+,37?,38+,39-,40+/m0/s1
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n/an/a 6n/an/an/an/an/an/a


TBA

Assay Description
Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50


Citation and Details
More data for this
Ligand-Target Pair
Motilin receptor


(Oryctolagus cuniculus)
BDBM50268377
PNG
((S)-2-amino-N-((S)-1-((S)-1-amino-3-(3-tert-butyl-...)
Show SMILES CC(C)(C)c1cc(C[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)Cc2ccccc2)C(N)=O)ccc1O
Show InChI InChI=1S/C31H38N4O4/c1-31(2,3)23-16-22(14-15-27(23)36)19-25(28(33)37)34-30(39)26(18-21-12-8-5-9-13-21)35-29(38)24(32)17-20-10-6-4-7-11-20/h4-16,24-26,36H,17-19,32H2,1-3H3,(H2,33,37)(H,34,39)(H,35,38)/t24-,25-,26-/m0/s1
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n/an/a 6n/an/an/an/an/an/a



Chugai Pharmaceutical Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]motilin from MTL receptor in rabbit duodenum homogenate


Citation and Details
More data for this
Ligand-Target Pair
Motilin receptor


(Oryctolagus cuniculus)
BDBM50421351
PNG
(CHEMBL27424)
Show SMILES CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC([C@H]2O)N(C)C(C)C)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC
Show InChI InChI=1S/C40H69NO12/c1-16-28-40(12,47-15)33(43)23(6)31-21(4)18-39(11,53-31)35(52-37-30(42)27(17-22(5)48-37)41(13)20(2)3)24(7)32(25(8)36(45)50-28)51-29-19-38(10,46-14)34(44)26(9)49-29/h20,22-30,32,34-35,37,42,44H,16-19H2,1-15H3/t22?,23-,24?,25?,26?,27?,28?,29-,30+,32?,34-,35+,37?,38+,39-,40+/m0/s1
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n/an/a 6n/an/an/an/an/an/a


TBA

Assay Description
In vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenate


Citation and Details
More data for this
Ligand-Target Pair
Motilin receptor


(Oryctolagus cuniculus)
BDBM50421349
PNG
(CHEMBL265495)
Show SMILES CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC([C@H]2O)N(C)CC)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC
Show InChI InChI=1S/C39H67NO12/c1-15-27-39(11,46-14)32(42)22(5)30-20(3)18-38(10,52-30)34(51-36-29(41)26(40(12)16-2)17-21(4)47-36)23(6)31(24(7)35(44)49-27)50-28-19-37(9,45-13)33(43)25(8)48-28/h21-29,31,33-34,36,41,43H,15-19H2,1-14H3/t21?,22-,23?,24?,25?,26?,27?,28-,29+,31?,33-,34+,36?,37+,38-,39+/m0/s1
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n/an/a 6.5n/an/an/an/an/an/a


TBA

Assay Description
Concentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution fo...


Citation and Details
More data for this
Ligand-Target Pair
Motilin receptor


(Oryctolagus cuniculus)
BDBM50421349
PNG
(CHEMBL265495)
Show SMILES CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC([C@H]2O)N(C)CC)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC
Show InChI InChI=1S/C39H67NO12/c1-15-27-39(11,46-14)32(42)22(5)30-20(3)18-38(10,52-30)34(51-36-29(41)26(40(12)16-2)17-21(4)47-36)23(6)31(24(7)35(44)49-27)50-28-19-37(9,45-13)33(43)25(8)48-28/h21-29,31,33-34,36,41,43H,15-19H2,1-14H3/t21?,22-,23?,24?,25?,26?,27?,28-,29+,31?,33-,34+,36?,37+,38-,39+/m0/s1
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n/an/a 6.5n/an/an/an/an/an/a


TBA

Assay Description
In vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tis...


Citation and Details
More data for this
Ligand-Target Pair
Motilin receptor


(Homo sapiens)
BDBM50421367
PNG
(CHEMBL351216)
Show SMILES CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC([C@H]2O)N(C)C(C)C)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)OC
Show InChI InChI=1S/C40H71NO12/c1-16-28-40(12,47-15)33(43)23(6)31-21(4)18-39(11,53-31)35(52-37-30(42)27(17-22(5)48-37)41(13)20(2)3)24(7)32(25(8)36(45)50-28)51-29-19-38(10,46-14)34(44)26(9)49-29/h20,22-30,32-35,37,42-44H,16-19H2,1-15H3/t22?,23-,24?,25?,26?,27?,28?,29-,30+,32?,33+,34-,35+,37?,38+,39-,40+/m0/s1
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n/an/a 6.90n/an/an/an/an/an/a


TBA

Assay Description
Compound was tested for in vitro motilin receptor binding affinity


Citation and Details
More data for this
Ligand-Target Pair
Motilin receptor


(Oryctolagus cuniculus)
BDBM50108830
PNG
(2-Amino-N-[6-(3-tert-butyl-4-hydroxy-benzyl)-2,5,8...)
Show SMILES CC(C)(C)c1cc(CC2NC(=O)C(CCCCNC(=O)CNC2=O)NC(=O)C(N)Cc2ccccc2)ccc1O
Show InChI InChI=1S/C30H41N5O5/c1-30(2,3)21-15-20(12-13-25(21)36)17-24-28(39)33-18-26(37)32-14-8-7-11-23(29(40)35-24)34-27(38)22(31)16-19-9-5-4-6-10-19/h4-6,9-10,12-13,15,22-24,36H,7-8,11,14,16-18,31H2,1-3H3,(H,32,37)(H,33,39)(H,34,38)(H,35,40)
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n/an/a 7n/an/an/an/an/an/a



Chugai Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the motilin receptor (MTL-R)


J Med Chem 45: 670-5 (2002)

More data for this
Ligand-Target Pair
Motilin receptor


(Homo sapiens)
BDBM50421368
PNG
(CHEMBL166642)
Show SMILES CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC([C@H]2O)N(C)C)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)OC
Show InChI InChI=1S/C38H67NO12/c1-15-26-38(10,45-14)31(41)21(4)29-19(2)17-37(9,51-29)33(50-35-28(40)25(39(11)12)16-20(3)46-35)22(5)30(23(6)34(43)48-26)49-27-18-36(8,44-13)32(42)24(7)47-27/h20-28,30-33,35,40-42H,15-18H2,1-14H3/t20?,21-,22?,23?,24?,25?,26?,27-,28+,30?,31+,32-,33+,35?,36+,37-,38+/m0/s1
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n/an/a 7.60n/an/an/an/an/an/a


TBA

Assay Description
Compound was tested for in vitro motilin receptor binding affinity


Citation and Details
More data for this
Ligand-Target Pair
Motilin receptor


(Oryctolagus cuniculus)
BDBM50421351
PNG
(CHEMBL27424)
Show SMILES CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC([C@H]2O)N(C)C(C)C)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC
Show InChI InChI=1S/C40H69NO12/c1-16-28-40(12,47-15)33(43)23(6)31-21(4)18-39(11,53-31)35(52-37-30(42)27(17-22(5)48-37)41(13)20(2)3)24(7)32(25(8)36(45)50-28)51-29-19-38(10,46-14)34(44)26(9)49-29/h20,22-30,32,34-35,37,42,44H,16-19H2,1-15H3/t22?,23-,24?,25?,26?,27?,28?,29-,30+,32?,34-,35+,37?,38+,39-,40+/m0/s1
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n/an/a 7.90n/an/an/an/an/an/a


TBA

Assay Description
Concentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution fo...


Citation and Details
More data for this
Ligand-Target Pair
Motilin receptor


(Oryctolagus cuniculus)
BDBM50421351
PNG
(CHEMBL27424)
Show SMILES CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC([C@H]2O)N(C)C(C)C)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC
Show InChI InChI=1S/C40H69NO12/c1-16-28-40(12,47-15)33(43)23(6)31-21(4)18-39(11,53-31)35(52-37-30(42)27(17-22(5)48-37)41(13)20(2)3)24(7)32(25(8)36(45)50-28)51-29-19-38(10,46-14)34(44)26(9)49-29/h20,22-30,32,34-35,37,42,44H,16-19H2,1-15H3/t22?,23-,24?,25?,26?,27?,28?,29-,30+,32?,34-,35+,37?,38+,39-,40+/m0/s1
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n/an/a 7.90n/an/an/an/an/an/a


TBA

Assay Description
In vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tis...


Citation and Details
More data for this
Ligand-Target Pair
Motilin receptor


(Homo sapiens)
BDBM50214272
PNG
((5R,8R,11S)-11-(aminomethyl)-8-(propan-2-yl)-5-{[3...)
Show SMILES CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(c2)C(F)(F)F)NCCOc2ccccc2CCCNC(=O)[C@H](CN)NC1=O
Show InChI InChI=1S/C29H38F3N5O4/c1-18(2)25-28(40)36-23(17-33)26(38)35-12-6-9-20-8-3-4-11-24(20)41-14-13-34-22(27(39)37-25)16-19-7-5-10-21(15-19)29(30,31)32/h3-5,7-8,10-11,15,18,22-23,25,34H,6,9,12-14,16-17,33H2,1-2H3,(H,35,38)(H,36,40)(H,37,39)/t22-,23+,25-/m1/s1
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n/an/a 8n/an/an/an/an/an/a



Tranzyme Pharma Inc.

Curated by ChEMBL


Assay Description
Antagonist activity against human motilin receptor in aequoscreen cells assessed as inhibition of motilin induced calcium release by aequorin assay


Citation and Details
More data for this
Ligand-Target Pair
Motilin receptor


(Homo sapiens)
BDBM50186108
PNG
(CHEMBL209301 | N-(((1S,3R)-3-(N-benzylpivalamido)c...)
Show SMILES CC(C)(C)C(=O)N(Cc1ccccc1)[C@@H]1CCC[C@H](CN(C(=O)c2ccc(F)cc2)c2cccc(OCCN3CCCC3)c2)C1
Show InChI InChI=1S/C38H48FN3O3/c1-38(2,3)37(44)42(27-29-11-5-4-6-12-29)33-14-9-13-30(25-33)28-41(36(43)31-17-19-32(39)20-18-31)34-15-10-16-35(26-34)45-24-23-40-21-7-8-22-40/h4-6,10-12,15-20,26,30,33H,7-9,13-14,21-25,27-28H2,1-3H3/t30-,33+/m0/s1
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n/an/a 8n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Activity at rabbit duodenum motilin receptor by tissue contractility assay


Citation and Details
More data for this
Ligand-Target Pair
Motilin receptor


(Homo sapiens)
BDBM50421369
PNG
(CHEMBL262052)
Show SMILES CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC([C@H]2O)N(C)CC)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)OC
Show InChI InChI=1S/C39H69NO12/c1-15-27-39(11,46-14)32(42)22(5)30-20(3)18-38(10,52-30)34(51-36-29(41)26(40(12)16-2)17-21(4)47-36)23(6)31(24(7)35(44)49-27)50-28-19-37(9,45-13)33(43)25(8)48-28/h21-29,31-34,36,41-43H,15-19H2,1-14H3/t21?,22-,23?,24?,25?,26?,27?,28-,29+,31?,32+,33-,34+,36?,37+,38-,39+/m0/s1
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n/an/a 8.30n/an/an/an/an/an/a


TBA

Assay Description
Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)


Citation and Details
More data for this
Ligand-Target Pair
Motilin receptor


(Oryctolagus cuniculus)
BDBM50421350
PNG
(CHEMBL27419)
Show SMILES CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC([C@H]2O)N(C)C)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC
Show InChI InChI=1S/C38H65NO12/c1-15-26-38(10,45-14)31(41)21(4)29-19(2)17-37(9,51-29)33(50-35-28(40)25(39(11)12)16-20(3)46-35)22(5)30(23(6)34(43)48-26)49-27-18-36(8,44-13)32(42)24(7)47-27/h20-28,30,32-33,35,40,42H,15-18H2,1-14H3/t20?,21-,22?,23?,24?,25?,26?,27-,28+,30?,32-,33+,35?,36+,37-,38+/m0/s1
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n/an/a 8.90n/an/an/an/an/an/a


TBA

Assay Description
Concentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution fo...


Citation and Details
More data for this
Ligand-Target Pair
Motilin receptor


(Oryctolagus cuniculus)
BDBM50421350
PNG
(CHEMBL27419)
Show SMILES CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC([C@H]2O)N(C)C)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC
Show InChI InChI=1S/C38H65NO12/c1-15-26-38(10,45-14)31(41)21(4)29-19(2)17-37(9,51-29)33(50-35-28(40)25(39(11)12)16-20(3)46-35)22(5)30(23(6)34(43)48-26)49-27-18-36(8,44-13)32(42)24(7)47-27/h20-28,30,32-33,35,40,42H,15-18H2,1-14H3/t20?,21-,22?,23?,24?,25?,26?,27-,28+,30?,32-,33+,35?,36+,37-,38+/m0/s1
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n/an/a 8.90n/an/an/an/an/an/a


TBA

Assay Description
In vitro binding affinity towards motilin receptor was determined after treatment with hydrochloric acid in rabbit small intestinal smooth muscle tis...


Citation and Details
More data for this
Ligand-Target Pair
Motilin receptor


(Oryctolagus cuniculus)
BDBM50421350
PNG
(CHEMBL27419)
Show SMILES CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC([C@H]2O)N(C)C)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC
Show InChI InChI=1S/C38H65NO12/c1-15-26-38(10,45-14)31(41)21(4)29-19(2)17-37(9,51-29)33(50-35-28(40)25(39(11)12)16-20(3)46-35)22(5)30(23(6)34(43)48-26)49-27-18-36(8,44-13)32(42)24(7)47-27/h20-28,30,32-33,35,40,42H,15-18H2,1-14H3/t20?,21-,22?,23?,24?,25?,26?,27-,28+,30?,32-,33+,35?,36+,37-,38+/m0/s1
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n/an/a 8.90n/an/an/an/an/an/a


TBA

Assay Description
Concentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution fo...


Citation and Details
More data for this
Ligand-Target Pair
Motilin receptor


(Oryctolagus cuniculus)
BDBM50421350
PNG
(CHEMBL27419)
Show SMILES CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC([C@H]2O)N(C)C)[C@]2(C)CC(C)=C(O2)[C@H](C)C(=O)[C@]1(C)OC
Show InChI InChI=1S/C38H65NO12/c1-15-26-38(10,45-14)31(41)21(4)29-19(2)17-37(9,51-29)33(50-35-28(40)25(39(11)12)16-20(3)46-35)22(5)30(23(6)34(43)48-26)49-27-18-36(8,44-13)32(42)24(7)47-27/h20-28,30,32-33,35,40,42H,15-18H2,1-14H3/t20?,21-,22?,23?,24?,25?,26?,27-,28+,30?,32-,33+,35?,36+,37-,38+/m0/s1
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n/an/a 9.10n/an/an/an/an/an/a


TBA

Assay Description
In vitro binding affinity towards motilin receptor was determined in rabbit small intestinal smooth muscle tissue homogenate


Citation and Details
More data for this
Ligand-Target Pair
Motilin receptor


(Homo sapiens)
BDBM50186103
PNG
((R)-1-((3-(3-chlorobenzyl)-3-(2,2,2-trichloroaceta...)
Show SMILES Clc1cccc(C[C@@]2(CCC(CN(C(=O)Nc3ccccc3)c3cccc(OCCN4CCOCC4)c3)=C2)NC(=O)C(Cl)(Cl)Cl)c1
Show InChI InChI=1S/C34H36Cl4N4O4/c35-27-7-4-6-25(20-27)22-33(40-31(43)34(36,37)38)13-12-26(23-33)24-42(32(44)39-28-8-2-1-3-9-28)29-10-5-11-30(21-29)46-19-16-41-14-17-45-18-15-41/h1-11,20-21,23H,12-19,22,24H2,(H,39,44)(H,40,43)/t33-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of [125]I-motilin binding to rabbit motilin receptor


Citation and Details
More data for this
Ligand-Target Pair
Motilin receptor


(Homo sapiens)
BDBM50186108
PNG
(CHEMBL209301 | N-(((1S,3R)-3-(N-benzylpivalamido)c...)
Show SMILES CC(C)(C)C(=O)N(Cc1ccccc1)[C@@H]1CCC[C@H](CN(C(=O)c2ccc(F)cc2)c2cccc(OCCN3CCCC3)c2)C1
Show InChI InChI=1S/C38H48FN3O3/c1-38(2,3)37(44)42(27-29-11-5-4-6-12-29)33-14-9-13-30(25-33)28-41(36(43)31-17-19-32(39)20-18-31)34-15-10-16-35(26-34)45-24-23-40-21-7-8-22-40/h4-6,10-12,15-20,26,30,33H,7-9,13-14,21-25,27-28H2,1-3H3/t30-,33+/m0/s1
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n/an/a 10n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of [125]I-motilin binding to rabbit motilin receptor


Citation and Details
More data for this
Ligand-Target Pair
Motilin receptor


(Oryctolagus cuniculus)
BDBM50108832
PNG
(2-Amino-N-[2-(3-tert-butyl-4-hydroxy-benzyl)-3,7,1...)
Show SMILES CC(C)(C)c1cc(CC2NC(=O)C(CCCCNC(=O)CCNC2=O)NC(=O)C(N)Cc2ccccc2)ccc1O
Show InChI InChI=1S/C31H43N5O5/c1-31(2,3)22-17-21(12-13-26(22)37)19-25-29(40)34-16-14-27(38)33-15-8-7-11-24(30(41)36-25)35-28(39)23(32)18-20-9-5-4-6-10-20/h4-6,9-10,12-13,17,23-25,37H,7-8,11,14-16,18-19,32H2,1-3H3,(H,33,38)(H,34,40)(H,35,39)(H,36,41)
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n/an/a 10n/an/an/an/an/an/a



Chugai Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the motilin receptor (MTL-R)


J Med Chem 45: 670-5 (2002)

More data for this
Ligand-Target Pair
Motilin receptor


(Oryctolagus cuniculus)
BDBM50268376
PNG
((S)-2-amino-N-((S)-2-((S)-1-amino-3-(3-tert-butyl-...)
Show SMILES CC(C)(C)c1cc(C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccccc2)c2ccccc2)C(N)=O)ccc1O
Show InChI InChI=1S/C30H36N4O4/c1-30(2,3)22-16-20(14-15-25(22)35)18-24(27(32)36)33-29(38)26(21-12-8-5-9-13-21)34-28(37)23(31)17-19-10-6-4-7-11-19/h4-16,23-24,26,35H,17-18,31H2,1-3H3,(H2,32,36)(H,33,38)(H,34,37)/t23-,24-,26-/m0/s1
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n/an/a 12n/an/an/an/an/an/a



Chugai Pharmaceutical Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]motilin from MTL receptor in rabbit duodenum homogenate


Citation and Details
More data for this
Ligand-Target Pair
Motilin receptor


(Oryctolagus cuniculus)
BDBM50268378
PNG
((S)-2-amino-N-((3S,6S)-3-(3-tert-butyl-4-hydroxybe...)
Show SMILES CC(C)(C)c1cc(C[C@@H]2NC(=O)[C@H](CCCCCC(=O)CCNC2=O)NC(=O)[C@@H](N)Cc2ccccc2)ccc1O
Show InChI InChI=1S/C32H44N4O5/c1-32(2,3)24-18-22(14-15-28(24)38)20-27-30(40)34-17-16-23(37)12-8-5-9-13-26(31(41)36-27)35-29(39)25(33)19-21-10-6-4-7-11-21/h4,6-7,10-11,14-15,18,25-27,38H,5,8-9,12-13,16-17,19-20,33H2,1-3H3,(H,34,40)(H,35,39)(H,36,41)/t25-,26-,27-/m0/s1
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n/an/a 12n/an/an/an/an/an/a



Chugai Pharmaceutical Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]motilin from MTL receptor in rabbit duodenum homogenate


Citation and Details
More data for this
Ligand-Target Pair
Motilin receptor


(Homo sapiens)
BDBM50186102
PNG
(CHEMBL378317 | N-((3-(N-(3-nitrobenzyl)-2,2,2-tric...)
Show SMILES [O-][N+](=O)c1cccc(CN(C2CCCC(CN(C(=O)c3ccc(F)cc3)c3cccc(OCCN4CCCC4)c3)C2)C(=O)C(Cl)(Cl)Cl)c1
Show InChI InChI=1S/C35H38Cl3FN4O5/c36-35(37,38)34(45)42(24-26-7-4-10-31(21-26)43(46)47)29-8-3-6-25(20-29)23-41(33(44)27-12-14-28(39)15-13-27)30-9-5-11-32(22-30)48-19-18-40-16-1-2-17-40/h4-5,7,9-15,21-22,25,29H,1-3,6,8,16-20,23-24H2
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n/an/a 14n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of [125]I-motilin binding to rabbit motilin receptor


Citation and Details
More data for this
Ligand-Target Pair
Motilin receptor


(Homo sapiens)
BDBM50421367
PNG
(CHEMBL351216)
Show SMILES CCC1OC(=O)C(C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)C(C)O2)C(C)[C@@H](OC2OC(C)CC([C@H]2O)N(C)C(C)C)[C@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)OC
Show InChI InChI=1S/C40H71NO12/c1-16-28-40(12,47-15)33(43)23(6)31-21(4)18-39(11,53-31)35(52-37-30(42)27(17-22(5)48-37)41(13)20(2)3)24(7)32(25(8)36(45)50-28)51-29-19-38(10,46-14)34(44)26(9)49-29/h20,22-30,32-35,37,42-44H,16-19H2,1-15H3/t22?,23-,24?,25?,26?,27?,28?,29-,30+,32?,33+,34-,35+,37?,38+,39-,40+/m0/s1
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n/an/a 15n/an/an/an/an/an/a


TBA

Assay Description
Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)


Citation and Details
More data for this
Ligand-Target Pair
Motilin receptor


(Oryctolagus cuniculus)
BDBM50108833
PNG
(2-Amino-N-[3-(3-tert-butyl-4-hydroxy-benzyl)-2,5,1...)
Show SMILES CC(C)(C)c1cc(CC2NC(=O)C(CCCCNC(=O)CCCCCNC2=O)NC(=O)C(N)Cc2ccccc2)ccc1O
Show InChI InChI=1S/C34H49N5O5/c1-34(2,3)25-20-24(16-17-29(25)40)22-28-32(43)37-19-10-5-8-15-30(41)36-18-11-9-14-27(33(44)39-28)38-31(42)26(35)21-23-12-6-4-7-13-23/h4,6-7,12-13,16-17,20,26-28,40H,5,8-11,14-15,18-19,21-22,35H2,1-3H3,(H,36,41)(H,37,43)(H,38,42)(H,39,44)
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n/an/a 17n/an/an/an/an/an/a



Chugai Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the motilin receptor (MTL-R)


J Med Chem 45: 670-5 (2002)

More data for this
Ligand-Target Pair
Motilin receptor


(Homo sapiens)
BDBM50186113
PNG
((R)-1-((3-benzyl-3-(2,2,2-trichloroacetamido)cyclo...)
Show SMILES ClC(Cl)(Cl)C(=O)N[C@@]1(Cc2ccccc2)CCC(CN(C(=O)Nc2ccccc2)c2cccc(OCCN3CCOCC3)c2)=C1
Show InChI InChI=1S/C34H37Cl3N4O4/c35-34(36,37)31(42)39-33(23-26-8-3-1-4-9-26)15-14-27(24-33)25-41(32(43)38-28-10-5-2-6-11-28)29-12-7-13-30(22-29)45-21-18-40-16-19-44-20-17-40/h1-13,22,24H,14-21,23,25H2,(H,38,43)(H,39,42)/t33-/m1/s1
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n/an/a 20n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of [125]I-motilin binding to rabbit motilin receptor


Citation and Details
More data for this
Ligand-Target Pair
Motilin receptor


(Homo sapiens)
BDBM50186105
PNG
(CHEMBL382613 | rac-N-((3-(N-(3-chlorobenzyl)-2,2,2...)
Show SMILES Fc1ccc(cc1)C(=O)N(CC1CCCC(C1)N(Cc1cccc(Cl)c1)C(=O)C(Cl)(Cl)Cl)c1cccc(OCCN2CCCCC2)c1
Show InChI InChI=1S/C36H40Cl4FN3O3/c37-29-9-4-7-26(21-29)25-44(35(46)36(38,39)40)31-10-5-8-27(22-31)24-43(34(45)28-13-15-30(41)16-14-28)32-11-6-12-33(23-32)47-20-19-42-17-2-1-3-18-42/h4,6-7,9,11-16,21,23,27,31H,1-3,5,8,10,17-20,22,24-25H2
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n/an/a 21n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Activity at rabbit duodenum motilin receptor by tissue contractility assay


Citation and Details
More data for this
Ligand-Target Pair
Motilin receptor


(Homo sapiens)
BDBM50186116
PNG
(CHEMBL209024 | rac-1-((3-(N-benzylpivalamido)cyclo...)
Show SMILES CC(C)(C)C(=O)N(Cc1ccccc1)C1CCCC(CN(C(=O)Nc2ccccc2)c2cccc(OCCN3CCCC3)c2)C1
Show InChI InChI=1S/C38H50N4O3/c1-38(2,3)36(43)41(28-30-14-6-4-7-15-30)33-19-12-16-31(26-33)29-42(37(44)39-32-17-8-5-9-18-32)34-20-13-21-35(27-34)45-25-24-40-22-10-11-23-40/h4-9,13-15,17-18,20-21,27,31,33H,10-12,16,19,22-26,28-29H2,1-3H3,(H,39,44)
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n/an/a 21n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of [125]I-motilin binding to rabbit motilin receptor at 1 uM


Citation and Details
More data for this
Ligand-Target Pair
Motilin receptor


(Homo sapiens)
BDBM50199368
PNG
((9R,12R,15S)-12-isopropyl-9-(4-methoxy-benzyl)-15-...)
Show SMILES CCC[C@@H]1NC(=O)[C@H](NC(=O)[C@@H](Cc2ccc(OC)cc2)NCCOc2ccccc2CCCNC1=O)C(C)C
Show InChI InChI=1S/C31H44N4O5/c1-5-9-25-29(36)33-17-8-11-23-10-6-7-12-27(23)40-19-18-32-26(20-22-13-15-24(39-4)16-14-22)30(37)35-28(21(2)3)31(38)34-25/h6-7,10,12-16,21,25-26,28,32H,5,8-9,11,17-20H2,1-4H3,(H,33,36)(H,34,38)(H,35,37)/t25-,26+,28+/m0/s1
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n/an/a 23n/an/an/an/an/an/a



Tranzyme Pharma Inc.

Curated by ChEMBL


Assay Description
Activity at human MOTR expressed in CHO cells assessed as inhibition of motilin-induced calcium release


Citation and Details
More data for this
Ligand-Target Pair
Motilin receptor


(Oryctolagus cuniculus)
BDBM50268431
PNG
((S)-N-((S)-1-amino-3-(3-tert-butyl-4-hydroxyphenyl...)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N(C)[C@@H](Cc1ccc(O)c(c1)C(C)(C)C)C(N)=O
Show InChI InChI=1S/C28H40N4O4/c1-17(2)24(31-26(35)21(29)15-18-10-8-7-9-11-18)27(36)32(6)22(25(30)34)16-19-12-13-23(33)20(14-19)28(3,4)5/h7-14,17,21-22,24,33H,15-16,29H2,1-6H3,(H2,30,34)(H,31,35)/t21-,22-,24-/m0/s1
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n/an/a 24n/an/an/an/an/an/a



Chugai Pharmaceutical Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]motilin from MTL receptor in rabbit duodenum homogenate


Citation and Details
More data for this
Ligand-Target Pair
Motilin receptor


(Homo sapiens)
BDBM50186111
PNG
(CHEMBL379665 | rac-N-((3-(N-benzylpivalamido)cyclo...)
Show SMILES CC(C)(C)C(=O)N(Cc1ccccc1)C1CCCC(CN(C(=O)c2ccc(F)cc2)c2cccc(OCCN3CCCC3)c2)C1
Show InChI InChI=1S/C38H48FN3O3/c1-38(2,3)37(44)42(27-29-11-5-4-6-12-29)33-14-9-13-30(25-33)28-41(36(43)31-17-19-32(39)20-18-31)34-15-10-16-35(26-34)45-24-23-40-21-7-8-22-40/h4-6,10-12,15-20,26,30,33H,7-9,13-14,21-25,27-28H2,1-3H3
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n/an/a 24n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Activity at rabbit duodenum motilin receptor by tissue contractility assay


Citation and Details
More data for this
Ligand-Target Pair
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