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Found 386 hits Enz. Inhib. hit(s) with Target = 'Muscarinic receptor M2 and M3'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Muscarinic receptor M2 and M3


(RAT)
BDBM50018304
PNG
(11-(2-{2-[(Cycloheptyl-methyl-amino)-methyl]-piper...)
Show SMILES CN(CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc12)C1CCCCCC1
Show InChI InChI=1S/C28H37N5O2/c1-31(21-11-4-2-3-5-12-21)19-22-13-8-9-18-32(22)20-26(34)33-25-16-7-6-14-23(25)28(35)30-24-15-10-17-29-27(24)33/h6-7,10,14-17,21-22H,2-5,8-9,11-13,18-20H2,1H3,(H,30,35)
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College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenates


J Med Chem 37: 3775-88 (1994)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM50018304
PNG
(11-(2-{2-[(Cycloheptyl-methyl-amino)-methyl]-piper...)
Show SMILES CN(CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc12)C1CCCCCC1
Show InChI InChI=1S/C28H37N5O2/c1-31(21-11-4-2-3-5-12-21)19-22-13-8-9-18-32(22)20-26(34)33-25-16-7-6-14-23(25)28(35)30-24-15-10-17-29-27(24)33/h6-7,10,14-17,21-22H,2-5,8-9,11-13,18-20H2,1H3,(H,30,35)
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Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]-N-methylscopolamine as radioligand


J Med Chem 32: 1718-24 (1989)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM50018314
PNG
(11-(2-{2-[(Cyclohexyl-methyl-amino)-methyl]-piperi...)
Show SMILES CN(CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc12)C1CCCCC1
Show InChI InChI=1S/C27H35N5O2/c1-30(20-10-3-2-4-11-20)18-21-12-7-8-17-31(21)19-25(33)32-24-15-6-5-13-22(24)27(34)29-23-14-9-16-28-26(23)32/h5-6,9,13-16,20-21H,2-4,7-8,10-12,17-19H2,1H3,(H,29,34)
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Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]-N-methylscopolamine as radioligand


J Med Chem 32: 1718-24 (1989)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM50018314
PNG
(11-(2-{2-[(Cyclohexyl-methyl-amino)-methyl]-piperi...)
Show SMILES CN(CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc12)C1CCCCC1
Show InChI InChI=1S/C27H35N5O2/c1-30(20-10-3-2-4-11-20)18-21-12-7-8-17-31(21)19-25(33)32-24-15-6-5-13-22(24)27(34)29-23-14-9-16-28-26(23)32/h5-6,9,13-16,20-21H,2-4,7-8,10-12,17-19H2,1H3,(H,29,34)
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College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenates


J Med Chem 37: 3775-88 (1994)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM50018291
PNG
(11-{2-[2-(3-Diethylamino-propyl)-piperidin-1-yl]-a...)
Show SMILES CCN(CC)CCCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C26H35N5O2/c1-3-29(4-2)17-10-12-20-11-7-8-18-30(20)19-24(32)31-23-15-6-5-13-21(23)26(33)28-22-14-9-16-27-25(22)31/h5-6,9,13-16,20H,3-4,7-8,10-12,17-19H2,1-2H3,(H,28,33)
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College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenates


J Med Chem 37: 3775-88 (1994)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM50018298
PNG
(11-(2-{2-[(Butyl-methyl-amino)-methyl]-piperidin-1...)
Show SMILES CCCCN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C25H33N5O2/c1-3-4-15-28(2)17-19-10-7-8-16-29(19)18-23(31)30-22-13-6-5-11-20(22)25(32)27-21-12-9-14-26-24(21)30/h5-6,9,11-14,19H,3-4,7-8,10,15-18H2,1-2H3,(H,27,32)
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College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenates


J Med Chem 37: 3775-88 (1994)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM50018298
PNG
(11-(2-{2-[(Butyl-methyl-amino)-methyl]-piperidin-1...)
Show SMILES CCCCN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C25H33N5O2/c1-3-4-15-28(2)17-19-10-7-8-16-29(19)18-23(31)30-22-13-6-5-11-20(22)25(32)27-21-12-9-14-26-24(21)30/h5-6,9,11-14,19H,3-4,7-8,10,15-18H2,1-2H3,(H,27,32)
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Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]-N-methylscopolamine as radioligand


J Med Chem 32: 1718-24 (1989)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM50018291
PNG
(11-{2-[2-(3-Diethylamino-propyl)-piperidin-1-yl]-a...)
Show SMILES CCN(CC)CCCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C26H35N5O2/c1-3-29(4-2)17-10-12-20-11-7-8-18-30(20)19-24(32)31-23-15-6-5-13-21(23)26(33)28-22-14-9-16-27-25(22)31/h5-6,9,13-16,20H,3-4,7-8,10-12,17-19H2,1-2H3,(H,28,33)
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Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]-N-methylscopolamine as radioligand


J Med Chem 32: 1718-24 (1989)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM39341
PNG
(11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6...)
Show SMILES CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26)
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Dipartimento di Scienze Farmaceutiche - Università di Genova

Curated by ChEMBL


Assay Description
Displacement of [3H]-methylscopolamine binding to muscarinic M3 receptor in submaxillary salivary glands of rats.


Bioorg Med Chem Lett 9: 3031-4 (1999)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM50018313
PNG
(11-[2-(3-Diethylaminomethyl-piperidin-1-yl)-acetyl...)
Show SMILES CCN(CC)CC1CCCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)C1
Show InChI InChI=1S/C24H31N5O2/c1-3-27(4-2)15-18-9-8-14-28(16-18)17-22(30)29-21-12-6-5-10-19(21)24(31)26-20-11-7-13-25-23(20)29/h5-7,10-13,18H,3-4,8-9,14-17H2,1-2H3,(H,26,31)
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Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]-N-methylscopolamine as radioligand


J Med Chem 32: 1718-24 (1989)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM50018313
PNG
(11-[2-(3-Diethylaminomethyl-piperidin-1-yl)-acetyl...)
Show SMILES CCN(CC)CC1CCCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)C1
Show InChI InChI=1S/C24H31N5O2/c1-3-27(4-2)15-18-9-8-14-28(16-18)17-22(30)29-21-12-6-5-10-19(21)24(31)26-20-11-7-13-25-23(20)29/h5-7,10-13,18H,3-4,8-9,14-17H2,1-2H3,(H,26,31)
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College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenates


J Med Chem 37: 3775-88 (1994)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM50018300
PNG
(11-[3-(2-Diethylaminomethyl-piperidin-1-yl)-propio...)
Show SMILES CCN(CC)CC1CCCCN1CCC(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C25H33N5O2/c1-3-28(4-2)18-19-10-7-8-16-29(19)17-14-23(31)30-22-13-6-5-11-20(22)25(32)27-21-12-9-15-26-24(21)30/h5-6,9,11-13,15,19H,3-4,7-8,10,14,16-18H2,1-2H3,(H,27,32)
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Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]-N-methylscopolamine as radioligand


J Med Chem 32: 1718-24 (1989)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM50018300
PNG
(11-[3-(2-Diethylaminomethyl-piperidin-1-yl)-propio...)
Show SMILES CCN(CC)CC1CCCCN1CCC(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C25H33N5O2/c1-3-28(4-2)18-19-10-7-8-16-29(19)17-14-23(31)30-22-13-6-5-11-20(22)25(32)27-21-12-9-15-26-24(21)30/h5-6,9,11-13,15,19H,3-4,7-8,10,14,16-18H2,1-2H3,(H,27,32)
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College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenates


J Med Chem 37: 3775-88 (1994)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM39341
PNG
(11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6...)
Show SMILES CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26)
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Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]-N-methylscopolamine as radioligand


J Med Chem 32: 1718-24 (1989)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM50082333
PNG
(11-[2-(Octahydro-quinolizin-1-ylmethylsulfanyl)-ac...)
Show SMILES O=C(CSCC1CCCN2CCCCC12)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C24H28N4O2S/c29-22(16-31-15-17-7-6-14-27-13-4-3-10-20(17)27)28-21-11-2-1-8-18(21)24(30)26-19-9-5-12-25-23(19)28/h1-2,5,8-9,11-12,17,20H,3-4,6-7,10,13-16H2,(H,26,30)
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Dipartimento di Scienze Farmaceutiche - Università di Genova

Curated by ChEMBL


Assay Description
Displacement of [3H]-methylscopolamine binding to muscarinic M3 receptor in submaxillary salivary glands of rats.


Bioorg Med Chem Lett 9: 3031-4 (1999)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM50082335
PNG
(11-((S)-2-Octahydro-quinolizin-1-yl-thioacetyl)-5,...)
Show SMILES O=C1Nc2cccnc2N(C(=S)CC2CCCN3CCCC[C@@H]23)c2ccccc12
Show InChI InChI=1S/C23H26N4OS/c28-23-17-8-1-2-11-20(17)27(22-18(25-23)9-5-12-24-22)21(29)15-16-7-6-14-26-13-4-3-10-19(16)26/h1-2,5,8-9,11-12,16,19H,3-4,6-7,10,13-15H2,(H,25,28)/t16?,19-/m0/s1
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Dipartimento di Scienze Farmaceutiche - Università di Genova

Curated by ChEMBL


Assay Description
Displacement of [3H]-methylscopolamine binding to muscarinic M3 receptor in submaxillary salivary glands of rats.


Bioorg Med Chem Lett 9: 3031-4 (1999)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM50082334
PNG
(11-{2-[(Octahydro-quinolizin-1-ylmethyl)-amino]-ac...)
Show SMILES O=C(CNCC1CCCN2CCCCC12)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C24H29N5O2/c30-22(16-25-15-17-7-6-14-28-13-4-3-10-20(17)28)29-21-11-2-1-8-18(21)24(31)27-19-9-5-12-26-23(19)29/h1-2,5,8-9,11-12,17,20,25H,3-4,6-7,10,13-16H2,(H,27,31)
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Dipartimento di Scienze Farmaceutiche - Università di Genova

Curated by ChEMBL


Assay Description
Displacement of [3H]-methylscopolamine binding to muscarinic M3 receptor in submaxillary salivary glands of rats.


Bioorg Med Chem Lett 9: 3031-4 (1999)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM50018297
PNG
(11-[2-(2-Dimethylaminomethyl-piperidin-1-yl)-acety...)
Show SMILES CN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C22H27N5O2/c1-25(2)14-16-8-5-6-13-26(16)15-20(28)27-19-11-4-3-9-17(19)22(29)24-18-10-7-12-23-21(18)27/h3-4,7,9-12,16H,5-6,8,13-15H2,1-2H3,(H,24,29)
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n/an/a 1.00E+3n/an/an/an/an/an/a



College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenates


J Med Chem 37: 3775-88 (1994)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM50018292
PNG
(11-[2-(2-Diethylaminomethyl-piperidin-1-yl)-acetyl...)
Show SMILES CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(C)cc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C25H33N5O2/c1-4-28(5-2)16-19-9-6-7-14-29(19)17-23(31)30-22-12-11-18(3)15-20(22)25(32)27-21-10-8-13-26-24(21)30/h8,10-13,15,19H,4-7,9,14,16-17H2,1-3H3,(H,27,32)
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n/an/a 1.00E+3n/an/an/an/an/an/a



College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenates


J Med Chem 37: 3775-88 (1994)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM50018307
PNG
(11-{2-[2-(2-Diethylamino-ethyl)-piperidin-1-yl]-ac...)
Show SMILES CCN(CC)CCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C25H33N5O2/c1-3-28(4-2)17-14-19-10-7-8-16-29(19)18-23(31)30-22-13-6-5-11-20(22)25(32)27-21-12-9-15-26-24(21)30/h5-6,9,11-13,15,19H,3-4,7-8,10,14,16-18H2,1-2H3,(H,27,32)
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College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenates


J Med Chem 37: 3775-88 (1994)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM50007674
PNG
((+)-erythro 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydro...)
Show SMILES C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3/t16-,21-/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Compound was tested for the binding affinity against muscarinic acetylcholine receptor
by using [3H]QNB as radioligand


J Med Chem 34: 3085-90 (1991)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM50018307
PNG
(11-{2-[2-(2-Diethylamino-ethyl)-piperidin-1-yl]-ac...)
Show SMILES CCN(CC)CCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C25H33N5O2/c1-3-28(4-2)17-14-19-10-7-8-16-29(19)18-23(31)30-22-13-6-5-11-20(22)25(32)27-21-12-9-15-26-24(21)30/h5-6,9,11-13,15,19H,3-4,7-8,10,14,16-18H2,1-2H3,(H,27,32)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]-N-methylscopolamine as radioligand


J Med Chem 32: 1718-24 (1989)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM50018297
PNG
(11-[2-(2-Dimethylaminomethyl-piperidin-1-yl)-acety...)
Show SMILES CN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C22H27N5O2/c1-25(2)14-16-8-5-6-13-26(16)15-20(28)27-19-11-4-3-9-17(19)22(29)24-18-10-7-12-23-21(18)27/h3-4,7,9-12,16H,5-6,8,13-15H2,1-2H3,(H,24,29)
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Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]-N-methylscopolamine as radioligand


J Med Chem 32: 1718-24 (1989)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM50018292
PNG
(11-[2-(2-Diethylaminomethyl-piperidin-1-yl)-acetyl...)
Show SMILES CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(C)cc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C25H33N5O2/c1-4-28(5-2)16-19-9-6-7-14-29(19)17-23(31)30-22-12-11-18(3)15-20(22)25(32)27-21-10-8-13-26-24(21)30/h8,10-13,15,19H,4-7,9,14,16-17H2,1-3H3,(H,27,32)
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Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]-N-methylscopolamine as radioligand


J Med Chem 32: 1718-24 (1989)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM50034043
PNG
(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)
Show SMILES COc1cc(ccc1OCCCN1CCC(CC1)c1noc2cc(F)ccc12)C(C)=O
Show InChI InChI=1S/C24H27FN2O4/c1-16(28)18-4-7-21(23(14-18)29-2)30-13-3-10-27-11-8-17(9-12-27)24-20-6-5-19(25)15-22(20)31-26-24/h4-7,14-15,17H,3,8-13H2,1-2H3
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Hoechst-Roussel Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Binding affinity against Muscarinic acetylcholine receptor using [3H]quinuclidinyl benzilate


J Med Chem 38: 1119-31 (1995)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM50082336
PNG
(CHEMBL322378 | N-(4-Benzoyl-2-methyl-phenyl)-2-(R)...)
Show SMILES Cc1cc(ccc1NC(=O)CC1CCCN2CCCC[C@H]12)C(=O)c1ccccc1
Show InChI InChI=1S/C25H30N2O2/c1-18-16-21(25(29)19-8-3-2-4-9-19)12-13-22(18)26-24(28)17-20-10-7-15-27-14-6-5-11-23(20)27/h2-4,8-9,12-13,16,20,23H,5-7,10-11,14-15,17H2,1H3,(H,26,28)/t20?,23-/m1/s1
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n/an/a 1.30E+3n/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche - Università di Genova

Curated by ChEMBL


Assay Description
Displacement of [3H]-methylscopolamine binding to muscarinic M3 receptor in submaxillary salivary glands of rats.


Bioorg Med Chem Lett 9: 3031-4 (1999)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM50018311
PNG
(11-[2-(2-Piperidin-1-ylmethyl-piperidin-1-yl)-acet...)
Show SMILES O=C(CN1CCCCC1CN1CCCCC1)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C25H31N5O2/c31-23(18-29-16-7-4-9-19(29)17-28-14-5-1-6-15-28)30-22-12-3-2-10-20(22)25(32)27-21-11-8-13-26-24(21)30/h2-3,8,10-13,19H,1,4-7,9,14-18H2,(H,27,32)
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Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity of compound for glandular Muscarinic acetylcholine receptor M3 in rat using 0.3 nM [3H]-N-methylscopolamine as radioligand


J Med Chem 32: 1718-24 (1989)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM50018293
PNG
(11-(2-{2-[(Ethyl-methyl-amino)-methyl]-piperidin-1...)
Show SMILES CCN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C23H29N5O2/c1-3-26(2)15-17-9-6-7-14-27(17)16-21(29)28-20-12-5-4-10-18(20)23(30)25-19-11-8-13-24-22(19)28/h4-5,8,10-13,17H,3,6-7,9,14-16H2,1-2H3,(H,25,30)
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College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenates


J Med Chem 37: 3775-88 (1994)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM50018311
PNG
(11-[2-(2-Piperidin-1-ylmethyl-piperidin-1-yl)-acet...)
Show SMILES O=C(CN1CCCCC1CN1CCCCC1)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C25H31N5O2/c31-23(18-29-16-7-4-9-19(29)17-28-14-5-1-6-15-28)30-22-12-3-2-10-20(22)25(32)27-21-11-8-13-26-24(21)30/h2-3,8,10-13,19H,1,4-7,9,14-18H2,(H,27,32)
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College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenates


J Med Chem 37: 3775-88 (1994)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM50018310
PNG
(11-[2-(2-Pyrrolidin-1-ylmethyl-piperidin-1-yl)-ace...)
Show SMILES O=C(CN1CCCCC1CN1CCCC1)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C24H29N5O2/c30-22(17-28-15-4-3-8-18(28)16-27-13-5-6-14-27)29-21-11-2-1-9-19(21)24(31)26-20-10-7-12-25-23(20)29/h1-2,7,9-12,18H,3-6,8,13-17H2,(H,26,31)
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College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenates


J Med Chem 37: 3775-88 (1994)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM50018302
PNG
(9-Chloro-11-[2-(2-diethylaminomethyl-piperidin-1-y...)
Show SMILES CCN(CC)CC1CCCCN1CC(=O)N1c2cc(Cl)ccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C24H30ClN5O2/c1-3-28(4-2)15-18-8-5-6-13-29(18)16-22(31)30-21-14-17(25)10-11-19(21)24(32)27-20-9-7-12-26-23(20)30/h7,9-12,14,18H,3-6,8,13,15-16H2,1-2H3,(H,27,32)
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College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenates


J Med Chem 37: 3775-88 (1994)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM50018310
PNG
(11-[2-(2-Pyrrolidin-1-ylmethyl-piperidin-1-yl)-ace...)
Show SMILES O=C(CN1CCCCC1CN1CCCC1)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C24H29N5O2/c30-22(17-28-15-4-3-8-18(28)16-27-13-5-6-14-27)29-21-11-2-1-9-19(21)24(31)26-20-10-7-12-25-23(20)29/h1-2,7,9-12,18H,3-6,8,13-17H2,(H,26,31)
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Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]-N-methylscopolamine as radioligand


J Med Chem 32: 1718-24 (1989)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM50018302
PNG
(9-Chloro-11-[2-(2-diethylaminomethyl-piperidin-1-y...)
Show SMILES CCN(CC)CC1CCCCN1CC(=O)N1c2cc(Cl)ccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C24H30ClN5O2/c1-3-28(4-2)15-18-8-5-6-13-29(18)16-22(31)30-21-14-17(25)10-11-19(21)24(32)27-20-9-7-12-26-23(20)30/h7,9-12,14,18H,3-6,8,13,15-16H2,1-2H3,(H,27,32)
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Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]-N-methylscopolamine as radioligand


J Med Chem 32: 1718-24 (1989)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM50018293
PNG
(11-(2-{2-[(Ethyl-methyl-amino)-methyl]-piperidin-1...)
Show SMILES CCN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C23H29N5O2/c1-3-26(2)15-17-9-6-7-14-27(17)16-21(29)28-20-12-5-4-10-18(20)23(30)25-19-11-8-13-24-22(19)28/h4-5,8,10-13,17H,3,6-7,9,14-16H2,1-2H3,(H,25,30)
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Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]-N-methylscopolamine as radioligand


J Med Chem 32: 1718-24 (1989)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM50018299
PNG
(11-[2-(2-Diethylaminomethyl-pyrrolidin-1-yl)-acety...)
Show SMILES CCN(CC)CC1CCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C23H29N5O2/c1-3-26(4-2)15-17-9-8-14-27(17)16-21(29)28-20-12-6-5-10-18(20)23(30)25-19-11-7-13-24-22(19)28/h5-7,10-13,17H,3-4,8-9,14-16H2,1-2H3,(H,25,30)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]-N-methylscopolamine as radioligand


J Med Chem 32: 1718-24 (1989)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM50018294
PNG
(11-[2-(2-Diethylaminomethyl-piperidin-1-yl)-acetyl...)
Show SMILES CCN(CC)CC1CCCCN1CC(=O)N1c2cc(C)ccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C25H33N5O2/c1-4-28(5-2)16-19-9-6-7-14-29(19)17-23(31)30-22-15-18(3)11-12-20(22)25(32)27-21-10-8-13-26-24(21)30/h8,10-13,15,19H,4-7,9,14,16-17H2,1-3H3,(H,27,32)
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Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]-N-methylscopolamine as radioligand


J Med Chem 32: 1718-24 (1989)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM50018296
PNG
(11-[2-(2-Diethylaminomethyl-piperidin-1-yl)-acetyl...)
Show SMILES CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(CC)cc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C26H35N5O2/c1-4-19-12-13-23-21(16-19)26(33)28-22-11-9-14-27-25(22)31(23)24(32)18-30-15-8-7-10-20(30)17-29(5-2)6-3/h9,11-14,16,20H,4-8,10,15,17-18H2,1-3H3,(H,28,33)
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College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenates


J Med Chem 37: 3775-88 (1994)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM50018296
PNG
(11-[2-(2-Diethylaminomethyl-piperidin-1-yl)-acetyl...)
Show SMILES CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(CC)cc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C26H35N5O2/c1-4-19-12-13-23-21(16-19)26(33)28-22-11-9-14-27-25(22)31(23)24(32)18-30-15-8-7-10-20(30)17-29(5-2)6-3/h9,11-14,16,20H,4-8,10,15,17-18H2,1-3H3,(H,28,33)
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Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]-N-methylscopolamine as radioligand


J Med Chem 32: 1718-24 (1989)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM50018294
PNG
(11-[2-(2-Diethylaminomethyl-piperidin-1-yl)-acetyl...)
Show SMILES CCN(CC)CC1CCCCN1CC(=O)N1c2cc(C)ccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C25H33N5O2/c1-4-28(5-2)16-19-9-6-7-14-29(19)17-23(31)30-22-15-18(3)11-12-20(22)25(32)27-21-10-8-13-26-24(21)30/h8,10-13,15,19H,4-7,9,14,16-17H2,1-3H3,(H,27,32)
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College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenates


J Med Chem 37: 3775-88 (1994)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM50018299
PNG
(11-[2-(2-Diethylaminomethyl-pyrrolidin-1-yl)-acety...)
Show SMILES CCN(CC)CC1CCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C23H29N5O2/c1-3-26(4-2)15-17-9-8-14-27(17)16-21(29)28-20-12-6-5-10-18(20)23(30)25-19-11-7-13-24-22(19)28/h5-7,10-13,17H,3-4,8-9,14-16H2,1-2H3,(H,25,30)
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College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenates


J Med Chem 37: 3775-88 (1994)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM50018301
PNG
(11-[2-(2-Ethylaminomethyl-piperidin-1-yl)-acetyl]-...)
Show SMILES CCNCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C22H27N5O2/c1-2-23-14-16-8-5-6-13-26(16)15-20(28)27-19-11-4-3-9-17(19)22(29)25-18-10-7-12-24-21(18)27/h3-4,7,9-12,16,23H,2,5-6,8,13-15H2,1H3,(H,25,29)
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n/an/a 3.00E+3n/an/an/an/an/an/a



College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenates


J Med Chem 37: 3775-88 (1994)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM50018301
PNG
(11-[2-(2-Ethylaminomethyl-piperidin-1-yl)-acetyl]-...)
Show SMILES CCNCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C22H27N5O2/c1-2-23-14-16-8-5-6-13-26(16)15-20(28)27-19-11-4-3-9-17(19)22(29)25-18-10-7-12-24-21(18)27/h3-4,7,9-12,16,23H,2,5-6,8,13-15H2,1H3,(H,25,29)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]-N-methylscopolamine as radioligand


J Med Chem 32: 1718-24 (1989)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM50231845
PNG
(CHEMBL255523 | N-(3-chloro-4-(4-ethylpiperazin-1-y...)
Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)CCC2CCCC2)cc1Cl
Show InChI InChI=1S/C20H30ClN3O/c1-2-23-11-13-24(14-12-23)19-9-8-17(15-18(19)21)22-20(25)10-7-16-5-3-4-6-16/h8-9,15-16H,2-7,10-14H2,1H3,(H,22,25)
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n/an/a 3.10E+3n/an/an/an/an/an/a



Vanderbilt Institute of Chemical Biology

Curated by ChEMBL


Assay Description
Antagonist activity at rat muscarinic M3 receptor expressed in CHO cells by calcium mobilization assay


Bioorg Med Chem Lett 18: 885-90 (2008)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM50450970
PNG
(CHEMBL2111621)
Show SMILES O=C(C[C@H]1CCCN2CCCCC12)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C23H26N4O2/c28-21(15-16-7-6-14-26-13-4-3-10-19(16)26)27-20-11-2-1-8-17(20)23(29)25-18-9-5-12-24-22(18)27/h1-2,5,8-9,11-12,16,19H,3-4,6-7,10,13-15H2,(H,25,29)/t16-,19?/m1/s1
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n/an/a 3.50E+3n/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche - Università di Genova

Curated by ChEMBL


Assay Description
Displacement of [3H]-methylscopolamine binding to muscarinic M3 receptor in submaxillary salivary glands of rats.


Bioorg Med Chem Lett 9: 3031-4 (1999)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM50018305
PNG
(8-Bromo-11-[2-(2-diethylaminomethyl-piperidin-1-yl...)
Show SMILES CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(Br)cc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C24H30BrN5O2/c1-3-28(4-2)15-18-8-5-6-13-29(18)16-22(31)30-21-11-10-17(25)14-19(21)24(32)27-20-9-7-12-26-23(20)30/h7,9-12,14,18H,3-6,8,13,15-16H2,1-2H3,(H,27,32)
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n/an/a 4.00E+3n/an/an/an/an/an/a



College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenates


J Med Chem 37: 3775-88 (1994)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM50018306
PNG
(8-Chloro-11-[2-(2-diethylaminomethyl-piperidin-1-y...)
Show SMILES CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(Cl)cc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C24H30ClN5O2/c1-3-28(4-2)15-18-8-5-6-13-29(18)16-22(31)30-21-11-10-17(25)14-19(21)24(32)27-20-9-7-12-26-23(20)30/h7,9-12,14,18H,3-6,8,13,15-16H2,1-2H3,(H,27,32)
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n/an/a 4.00E+3n/an/an/an/an/an/a



College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenates


J Med Chem 37: 3775-88 (1994)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM50018309
PNG
(11-[2-(2-Morpholin-4-ylmethyl-piperidin-1-yl)-acet...)
Show SMILES O=C(CN1CCCCC1CN1CCOCC1)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C24H29N5O3/c30-22(17-28-11-4-3-6-18(28)16-27-12-14-32-15-13-27)29-21-9-2-1-7-19(21)24(31)26-20-8-5-10-25-23(20)29/h1-2,5,7-10,18H,3-4,6,11-17H2,(H,26,31)
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n/an/a 4.00E+3n/an/an/an/an/an/a



College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenates


J Med Chem 37: 3775-88 (1994)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM50018309
PNG
(11-[2-(2-Morpholin-4-ylmethyl-piperidin-1-yl)-acet...)
Show SMILES O=C(CN1CCCCC1CN1CCOCC1)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C24H29N5O3/c30-22(17-28-11-4-3-6-18(28)16-27-12-14-32-15-13-27)29-21-9-2-1-7-19(21)24(31)26-20-8-5-10-25-23(20)29/h1-2,5,7-10,18H,3-4,6,11-17H2,(H,26,31)
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n/an/a 4.00E+3n/an/an/an/an/an/a



Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]-N-methylscopolamine as radioligand


J Med Chem 32: 1718-24 (1989)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM50018312
PNG
(11-[2-(4-Diethylaminomethyl-piperidin-1-yl)-acetyl...)
Show SMILES CCN(CC)CC1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C24H31N5O2/c1-3-27(4-2)16-18-11-14-28(15-12-18)17-22(30)29-21-10-6-5-8-19(21)24(31)26-20-9-7-13-25-23(20)29/h5-10,13,18H,3-4,11-12,14-17H2,1-2H3,(H,26,31)
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Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Binding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]-N-methylscopolamine as radioligand


J Med Chem 32: 1718-24 (1989)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM50018312
PNG
(11-[2-(4-Diethylaminomethyl-piperidin-1-yl)-acetyl...)
Show SMILES CCN(CC)CC1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C24H31N5O2/c1-3-27(4-2)16-18-11-14-28(15-12-18)17-22(30)29-21-10-6-5-8-19(21)24(31)26-20-9-7-13-25-23(20)29/h5-10,13,18H,3-4,11-12,14-17H2,1-2H3,(H,26,31)
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College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenates


J Med Chem 37: 3775-88 (1994)

More data for this
Ligand-Target Pair
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